Effect of “Cuti Cuti” Extract (Blechnum Asplenioides) on Intestinal Motility in Albino Mice

Introduction: Intestinal motility is regulated by the enteric nervous system, which responds to contractile changes. Constipation is one of its main disorders. Although prokinetic drugs are effective, they are associated with adverse effects. Therefore, the use of medicinal plants represents an innovative therapeutic alternative. Methods: An experimental study was conducted in 40 male albino Mus musculus mice. Two doses (250 and 500 mg/kg) of hydroalcoholic extract of Blechnum asplenioides were administered, as well as metoclopramide (10 mg/kg) and loperamide (5 mg/kg), distributed into five study groups. Gastric motility was assessed by measuring the distance traveled by activated charcoal 30 minutes after administration of the test substances. Results: ANOVA test revealed significant differences (P<0.05; 95% CI). The extract of Blechnum showed a prokinetic effect on gastric motility, with the 250 mg/kg dose counteracting the inhibitory action of loperamide. Discussion: The findings indicate that Blechnum asplenioides extract improves intestinal motility at evaluated doses, possibly due to compounds such as flavonoids and tannins. The significant difference between the 250 mg/kg dose and loperamide suggests antagonism to its inhibitory effect. However, no additional benefit was observed at higher doses, highlighting the importance of further studies to clarify mechanisms, safety, and clinical relevance. Extrapolation to humans should be made cautiously since animal models do not always replicate human physiology. Conclusion: The extract of Blechnum asplenioides demonstrates a prokinetic effect in albino mice, likely mediated by bioactive compounds and antioxidant properties. Further research is needed to confirm its mechanism, safety, and potential therapeutic application in humans.