02706nas a2200241 4500008004100000245010000041210006900141260001400210300001200224490000700236520195400243653001302197653002402210653001502234653002102249653001902270100003202289700002702321700003002348700002202378700002402400856004002424 2026 eng d00aEffect of “Cuti Cuti” Extract (Blechnum Asplenioides) on Intestinal Motility in Albino Mice0 aEffect of Cuti Cuti Extract Blechnum Asplenioides on Intestinal  cJune 2026 a113-1190 v183 a

Introduction: Intestinal motility is regulated by the enteric nervous system, which responds to contractile changes. Constipation is one of its main disorders. Although prokinetic drugs are effective, they are associated with adverse effects. Therefore, the use of medicinal plants represents an innovative therapeutic alternative. Methods: An experimental study was conducted in 40 male albino Mus musculus mice. Two doses (250 and 500 mg/kg) of hydroalcoholic extract of Blechnum asplenioides were administered, as well as metoclopramide (10 mg/kg) and loperamide (5 mg/kg), distributed into five study groups. Gastric motility was assessed by measuring the distance traveled by activated charcoal 30 minutes after administration of the test substances. Results: ANOVA test revealed significant differences (P<0.05; 95% CI). The extract of Blechnum showed a prokinetic effect on gastric motility, with the 250 mg/kg dose counteracting the inhibitory action of loperamide. Discussion: The findings indicate that Blechnum asplenioides extract improves intestinal motility at evaluated doses, possibly due to compounds such as flavonoids and tannins. The significant difference between the 250 mg/kg dose and loperamide suggests antagonism to its inhibitory effect. However, no additional benefit was observed at higher doses, highlighting the importance of further studies to clarify mechanisms, safety, and clinical relevance. Extrapolation to humans should be made cautiously since animal models do not always replicate human physiology. Conclusion: The extract of Blechnum asplenioides demonstrates a prokinetic effect in albino mice, likely mediated by bioactive compounds and antioxidant properties. Further research is needed to confirm its mechanism, safety, and potential therapeutic application in humans.

10aBlechnum10aintestinal motility10aloperamide10aMedicinal plants10ametoclopramide1 aChalco, Xiomara, C. Benaven1 aAgurto, Elena, Hidalgo1 aHernandez, Thalia, Suarez1 aLens-Sardon, Luis1 aHuaccho-Rojas, Juan uhttps://www.phcogj.com/article/2614