<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Xiomara C. Benavente Chalco</style></author><author><style face="normal" font="default" size="100%">Elena Hidalgo Agurto</style></author><author><style face="normal" font="default" size="100%">Thalia Suarez Hernandez</style></author><author><style face="normal" font="default" size="100%">Luis Lens-Sardon</style></author><author><style face="normal" font="default" size="100%">Juan  Huaccho-Rojas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of “Cuti Cuti” Extract (Blechnum Asplenioides) on Intestinal Motility in Albino Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Blechnum</style></keyword><keyword><style  face="normal" font="default" size="100%">intestinal motility</style></keyword><keyword><style  face="normal" font="default" size="100%">loperamide</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">metoclopramide</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">113-119</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Intestinal motility is regulated by the enteric nervous system, which responds to contractile changes. Constipation is one of its main disorders. Although prokinetic drugs are effective, they are associated with adverse effects. Therefore, the use of medicinal plants represents an innovative therapeutic alternative. &lt;strong&gt;Methods: &lt;/strong&gt;An experimental study was conducted in 40 male albino Mus musculus mice. Two doses (250 and 500 mg/kg) of hydroalcoholic extract of &lt;em&gt;Blechnum asplenioides&lt;/em&gt; were administered, as well as metoclopramide (10 mg/kg) and loperamide (5 mg/kg), distributed into five study groups. Gastric motility was assessed by measuring the distance traveled by activated charcoal 30 minutes after administration of the test substances. &lt;strong&gt;Results: &lt;/strong&gt;ANOVA test revealed significant differences (P&amp;lt;0.05; 95% CI). The extract of &lt;em&gt;Blechnum &lt;/em&gt;showed a prokinetic effect on gastric motility, with the 250 mg/kg dose counteracting the inhibitory action of loperamide. Discussion: The findings indicate that &lt;em&gt;Blechnum asplenioides&lt;/em&gt; extract improves intestinal motility at evaluated doses, possibly due to compounds such as flavonoids and tannins. The significant difference between the 250 mg/kg dose and loperamide suggests antagonism to its inhibitory effect. However, no additional benefit was observed at higher doses, highlighting the importance of further studies to clarify mechanisms, safety, and clinical relevance. Extrapolation to humans should be made cautiously since animal models do not always replicate human physiology. &lt;strong&gt;Conclusion: &lt;/strong&gt;The extract of &lt;em&gt;Blechnum asplenioides&lt;/em&gt; demonstrates a prokinetic effect in albino mice, likely mediated by bioactive compounds and antioxidant properties. Further research is needed to confirm its mechanism, safety, and potential therapeutic application in humans.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">113</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Xiomara C. Benavente Chalco&lt;sup&gt;1,2&lt;/sup&gt;, Elena Hidalgo Agurto&lt;sup&gt;3&lt;/sup&gt;, Thalia Suarez Hernandez&lt;sup&gt;1&lt;/sup&gt;, Luis Lens- Sardon&lt;sup&gt;4&lt;/sup&gt;, Juan Huaccho-Rojas&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;CHANGE Research Working Group, Carrera de Medicina Humana, Facultad de Ciencias de la Salud, Universidad Científica del Sur, Lima, Peru&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Sociedad Científica Médico Estudiantil Peruana, Lima, Perú.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Medicina Humana, Universidad de San Martín de Porres; Centro de Investigación de Medicina Tradicional y Farmacología, Lima, Perú.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad de San Martín de Porres, Facultad de Medicina Humana; Centro de Investigación de Medicina Tradicional y Farmacología. Lima, Perú&lt;/p&gt;
</style></auth-address></record></records></xml>