Integrating Ancient Therapeutics into Nutraceutical Oral Films for Alzheimer’s Neuroprotection

Background: There are many popular neuroprotective medicinal plants mentioned in Indian traditional medicine systems which need to made available to Alzheimer's patients in suitable dosage form. Objectives: Herbal nutraceutical in the form of oral fast dissolving film (OFDF) containing bioactive enriched fractions of traditionally well-known Indian nootropic plants will enhance neuroprotective efficacy and quality of life of Alzheimer's patients. Materials and Methods: The standardized extracts of Centella and Bacopa are prepared and formulated into oral films which further evaluated for pharmaceutical parameters, stability, safety and behavioural animal studies. Results and Conclusion: The modernised dosage form of traditional medicines in the form of oral films found to reduce dosage frequency due to enhanced bioavailability of bioactive enriched herbal extracts and is easy for administration to Alzheimer's patients. Behavioural animal studies exhibited promising multitargeted neurocognitive efficacy of developed oral films.