Abelmoschus esculentus Ameliorates Stress-Induced Cognitive Dysfunction via Antioxidant and Neuroprotective Mechanisms in Mice

Objective: The objective of this study was to determine if there were any effect of Abelmoschus esculentus on chronic stress induced memory loss. Methods: The Swiss Albino Mice (n=30) were divided into five groups, namely control, chronic stress (90 days), chronic stress and ethanolic extract of Abelmoschus esculentus(200mg/kg body weight), and Chronic stress followed by diazepam (2mg/kg body weight), Chronic stress followed by diazepam (2mg/kg body weight) and ethanolic extract of abelmoschus esculentus (200mg/kg body weight). At the end of the experimental period (90 days), animal blood was collected retro-orbitally to analyze the cortisol, Brain tissue was homogenized, and antioxidants and Acetylcholine esterase level was estimated. Results: The Results of the data indicated that administering stress for a duration of 90 days led to a noticeable decline in spatial learning abilities in mice. Our findings indicate that combination of Abelmoschus esculentus and diazepam showed there was an significant improvement in retaining memory. Conclusion: Study indicated that Abelmoschus esculentus shows promise as a viable treatment option for conditions of stress related memory impairment.