ArticleViewAbstractPharmacognosy Journal,2022,14,4,267-272.DOI:10.5530/pj.2022.14.95Published:August 2022Type:Original Article In Silico Screening of Bioactive Compounds from Syzygium cumini L. and Moringa oleifera L. Against SARS-CoV-2 via Tetra InhibitorsNur Sofiatul Aini, Viol Dhea Kharisma, Muhammad Hermawan Widyananda, Ahmad Affan Ali Murtadlo, Rasyadan Taufiq Probojati, Dora Dayu Rahma Turista, Muhammad Badrut Tamam, Vikash Jakhmola, Devni Prima Sari, Muhammad Thoriq Albari, Devi Pernamasari, Muhammad Arya Ghifari, Muhammad Raffi Ghifari, Riso Sari Mandeli, Muhardi, Budhi Oktavia, Trisna Kumala Sari, Titi Sriwahyuni, Putri Azhari, Mirella Fonda Maahury, ANM Ansori, and Rahadian Zainul Nur Sofiatul Aini1, Viol Dhea Kharisma2, Muhammad Hermawan Widyananda2,3, Ahmad Affan Ali Murtadlo2, Rasyadan Taufiq Probojati2,4, Dora Dayu Rahma Turista5, Muhammad Badrut Tamam6, Vikash Jakhmola7, Devni Prima Sari8,9, Muhammad Thoriq Albari8,10, Devi Pernamasari8,11, Muhammad Arya Ghifari8,10, Muhammad Raffi Ghifari8,10, Riso Sari Mandeli8,12, Muhardi8,13, Budhi Oktavia8,14, Trisna Kumala Sari8,14, Titi Sriwahyuni8,15, Putri Azhari8,16, Mirella Fonda Maahury17, ANM Ansori18, Rahadian Zainul8,14,* 1Faculty of Mathematics and Natural Sciences, State University of Surabaya, Surabaya, INDONESIA. 2Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA. 3Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA. 4Faculty of Agriculture, Universitas Kadiri, Kediri, INDONESIA. 5Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA. 6Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA. 7Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA. 8Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA. 9Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA. 10Department of Information Technology, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA. 11Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA. 12Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA. 13STMIK Universitas Hang Tuah Pekanbaru, INDONESIA. 14Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA. 15Department Electronic Engineering Education, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA. 16Department of Agricultural Technology, Faculty of Agricultural Technology, Andalas University, Padang, INDONESIA. 17Chemistry Department, Faculty Mathematics and Natural Sciences, Universitas Pattimura, Ambon, INDONESIA. 18Professor Nidom Foundation, Surabaya, Indonesia Abstract:The global pandemic of COVID-19 has caused disastrous consequences for both humans and the economy. The purpose of this study was to determine the potential of juwet (Syzygium cumini L.) and moringa (Moringa oleifera L.) as inhibitors of RBD spike, helicase, Mpro, and RdRp activity of SARS-CoV-2 with an in-silico approach. Samples were obtained from PubChem and RSCB PDB databases. The drug similarity analysis was determined using Swiss ADME and the Lipinski rule of five. Prediction of antivirus probabilities is carried out with PASS Online. Molecular screening is performed by molecular docking using PyRx. Visualization was used using PyMol and Discovery Studio. The bioactive compounds with the best antiviral potential had the lowest affinity bonds to the target proteins against RBD spike, helicase, Mpro, and RdRp of SARS-CoV-2. Results show that ellagic acid from java plum and myricetin from moringa have the best potential as potential antivirals. However, more research is required to validate the results of these computational predictions. Keywords:Antiviral agent, in silico, Moringa Oleifera L, SARS-CoV-2, Syzygium cumini L.View:PDF (539.72 KB) PDF Images Graphical Abstract ‹ The Effect of Omega-3 Rich Fish Oil on the Kidney Changes in Mice Induced by Azoxymethane and Dextran Sodium Sulfate up TLC Profiling and Phytochemical Screening of Various Extracts of Ochna integerrima (Lour.) Merr. from Kog Dong Keng Forest, Thailand ›