<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Inda Kania Meilani</style></author><author><style face="normal" font="default" size="100%">Ermi Girsang</style></author><author><style face="normal" font="default" size="100%">Yolanda Eliza Putri Lubis</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ultrasonographic and Biochemical Evaluation of the Hepatoprotective Effect of Cinnamomum burmannii Bark Extract in Carbon Tetrachloride–Induced Liver Injury</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cinnamon</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokine</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">751-759</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aimed to evaluate the hepatoprotective activity of ethanolic extract of cinnamon (&lt;em&gt;Cinnamomum burmannii&lt;/em&gt;) in male Wistar rats induced with carbon tetrachloride (CCl&lt;sub&gt;₄&lt;/sub&gt;). Cinnamon extract is known to contain bioactive compounds such as flavonoids and polyphenols, which play significant roles in antioxidant and anti-inflammatory mechanisms. Phytochemical analysis revealed that the extract contained total phenolic content of 71.55 mg GAE/g and flavonoid content of 0.41 mg QE/g, with a potent antioxidant activity indicated by an IC&lt;sub&gt;₅₀&lt;/sub&gt; value of 18.19 ppm. Administration of the extract for 28 days at a dose of 300 mg/kg body weight resulted in a significant reduction (P&amp;lt;0.05) in pro-inflammatory cytokines TNF-α, IL-6, and CRP levels compared to the negative control group. The 300 mg/kg dose showed the highest efficacy, with TNF-α levels approaching those of the normal group. Furthermore, liver function parameters improved, as evidenced by significant reductions in SGOT and SGPT enzyme levels, an increase in serum albumin (2.96 ± 0.52 g/dL), and a decrease in serum bilirubin to 0.102 ± 0.040 mg/dL. Ultrasonographic examination showed improved liver parenchymal homogeneity and a reduction in the number of nodules. Histopathological findings revealed a decrease in liver tissue damage score from moderate to mild. These findings suggest that &lt;em&gt;Cinnamomum burmannii&lt;/em&gt; extract has potential hepatoprotective effects through antiinflammatory, antioxidant, and hepatocellular recovery mechanisms. Therefore, this extract holds promise as a phytopharmaceutical candidate for complementary therapy in liver function disorders; however, further studies are required to isolate the active compounds and evaluate long-term toxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">751</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Inda Kania Meilani&lt;sup&gt;1*&lt;/sup&gt;, Ermi Girsang&lt;sup&gt;2&lt;/sup&gt;, Yolanda Eliza Putri Lubis&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eva Krishna Sutedja</style></author><author><style face="normal" font="default" size="100%">Eva Yustiana</style></author><author><style face="normal" font="default" size="100%">Yogi Faldian</style></author><author><style face="normal" font="default" size="100%">Hermin Aminah Usman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An Ulcerative Cutaneous Plasmacytosis of the Scalp</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cutaneous plasmacytosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypergammaglobulinemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasma cell</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">378-381</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Cutaneous plasmacytosis (CP) is a rare benign disorder characterized by polyclonal proliferation of plasma cells of unknown etiology, with potential for malignant transformation. Clinical manifestations include reddish-brown macules, papules, plaques, or nodules, and, infrequently, ulcerative lesions resembling cutaneous squamous cell carcinoma (SCC) or similar cutaneous neoplasms. &lt;strong&gt;Case: &lt;/strong&gt;Herein we reported a case of ulcerative CP which was initially suspected as SCC in a 77–year–old male. Physical examination revealed an ulcer with well–defined borders, and flat edges, with a granulation tissue base on the scalp which was suggested as SCC. Histopathological features showed infiltration of mature plasma cells in the perivascular area, polyclonal plasma cell population on kappa and lambda chain immunohistochemistry, and hypergammaglobulinemia on protein electrophoresis that supported the diagnosis of CP.&lt;strong&gt; Discussion:&lt;/strong&gt; Cutaneous plasmacytosis requires a comprehensive diagnostic evaluation, which typically includes clinical examination, histopathological analysis, immunohistochemistry, ancillary tests such as protein electrophoresis, and negative results from a diagnostic workup for systemic disease. &lt;strong&gt;Conclusion:&lt;/strong&gt; The complexity of CP manifestations necessitates a rigorous diagnostic approach, enabling the differentiation of this benign condition from malignancies with similar presentations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">378</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Eva Krishna Sutedja&lt;sup&gt;1,*&lt;/sup&gt;, Eva Yustiana&lt;sup&gt;1&lt;/sup&gt;, Yogi Faldian&lt;sup&gt;1&lt;/sup&gt;, Hermin Aminah Usman&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran–Dr. Hasan Sadikin General Hospital, Bandung, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sihning EJT</style></author><author><style face="normal" font="default" size="100%">Ni Komang Sri Dewi Untari</style></author><author><style face="normal" font="default" size="100%">Dian Maria Pia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Unlocking the Potential of Stingray (Dasyatis sephen) Extract: A Novel Investigation into EPA and DHA Effects on Lipid Metabolism in High-Fat Diet-Fed Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ApoB</style></keyword><keyword><style  face="normal" font="default" size="100%">Dasyatis sephen</style></keyword><keyword><style  face="normal" font="default" size="100%">HDL</style></keyword><keyword><style  face="normal" font="default" size="100%">stingray</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">28-36</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Dyslipidemia is a complex disturbance in lipid metabolism with notable implications for cardiovascular health. Considering the burden of cardiovascular disease (CVD) on global mortality, lipid regulation should be eminently prioritized. Stingray (&lt;em&gt;Dasyatis sephen&lt;/em&gt;) is one of the natural resources believed to be rich in lipid-regulating compounds: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We aimed to investigate the impact of the stingray extract on the lipid metabolism of Wistar rats subjected to a high-fat diet. &lt;strong&gt;Methods:&lt;/strong&gt; We adopted a true experimental design with three experiment groups: a negative control (standard diet and distilled water), a positive control (high-fat diet and distilled water), and a specified treatment group (high-fat diet and stingray extract). Serum samples were collected after 28 days of treatment and analyzed for HDL and ApoB levels as dyslipidemia markers. Statistical analysis included one-way ANOVA for HDL and non-parametric Kruskal-Wallis tests for ApoB levels, followed by post-hoc analysis.&lt;strong&gt; Results: &lt;/strong&gt;The results revealed worsening HDL and ApoB levels in the positive control group compared to the negative control group following a high-fat diet consumption. In contrast, the experiment group showed improvements in HDL and ApoB levels compared to the positive control group following the administration of the extract. However, only the dynamics in HDL level are significant (p&amp;lt;0.05), while the difference in ApoB levels among all treatment groups was not statistically significant (p&amp;gt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; This study highlights the potency of D. sephen extract in regulating lipid metabolism despite the complexity of lipid metabolism regulation and the challenges of the conventional reliance on HDL and ApoB as exclusive markers of cardiovascular health.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">28</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sihning EJT&lt;sup&gt;1*&lt;/sup&gt;, Ni Komang Sri Dewi Untari&lt;sup&gt;2&lt;/sup&gt;, Dian Maria Pia&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Lecturer at Department of Anatomy and Histology, Faculty of Medicine, Hang Tuah University, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Staff at Department of Neurology, Faculty of Medicine, Hang Tuah University, Surabaya, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ahmad Yanuar Safri</style></author><author><style face="normal" font="default" size="100%">Salim Harris</style></author><author><style face="normal" font="default" size="100%">Putera Dewa Haryono</style></author><author><style face="normal" font="default" size="100%">Ariane Benina Budiwan</style></author><author><style face="normal" font="default" size="100%">Eugenia Isadora</style></author><author><style face="normal" font="default" size="100%">Aisyah Fitriannisa Prawiningrum</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Unveiling Potential Therapies: Molecular Docking Analysis of CAMKK2 and Its Mutant Variants with CAMKK2 Inhibitors in Indonesian Patients with HIV-Sensory Neuropathy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CAMKK2 inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV-SN</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">SNP</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">46-51</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;HIV sensory neuropathy (HIV-SN) is one among many complications that impair patients’ quality of life. Studies in Asian and African populations found that single nucleotide polymorphisms (SNPs) of calcium/ calmodulin-dependent protein kinase 2 (CAMKK2) influence the risk of HIV-SN. This study attempts to explain the influence of CAMKK2 mutations on HIV SN by studying bioinformatics interactions between CAMKK2, its mutants, and their inhibitors by molecular docking with AutoDock in order to observe their interactions with CAMKK2 inhibitors. Results showed that CAMKK2’s binding energy with its native ligand (ATP) is stronger than the mutant variant of CAMKK2MT85 and CAMKK2MT363. Conversely, interaction between CAMKK2 and its inhibitors (KN-93, STO-609, and trifluoperazine) have the lowest mean binding energy compared to CAMKK2MT85 and CAMKK2MT363. This indicates that the mutant variants have weaker interactions with the native ligand and the inhibitors, therefore disrupting the normal function of CAMKK2, its interactions with the inhibitors, while increasing the likelihood of HIV-SN.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">46</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ahmad Yanuar Safri&lt;sup&gt;1,2,3,&lt;/sup&gt;*, Salim Harris&lt;sup&gt;2,3&lt;/sup&gt;, Putera Dewa Haryono&lt;sup&gt;2,3&lt;/sup&gt;, Ariane Benina Budiwan&lt;sup&gt;2,3&lt;/sup&gt;, Eugenia Isadora&lt;sup&gt;2,3&lt;/sup&gt;, Aisyah Fitriannisa Prawiningrum&lt;sup&gt;4&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine Universitas INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Neurology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Neurology Department, Cipto Mangunkusumo Hospital, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Bioinformatics Core Facilities IMERI, Medical Chemistry Department, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Medicine Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Qurrata Akyuni</style></author><author><style face="normal" font="default" size="100%">Agus Sulistiyono</style></author><author><style face="normal" font="default" size="100%">Hermanto Tri Joewono</style></author><author><style face="normal" font="default" size="100%">Lilik Djuari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Uterocervical Angle Anterior, Posterior, and Cervical Length Ultrasound as a Predictors for Successful Delay in Labor of Pregnant Women with Threatened Preterm Birth (PTB)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cervical Length</style></keyword><keyword><style  face="normal" font="default" size="100%">Preterm Delivery</style></keyword><keyword><style  face="normal" font="default" size="100%">Threatened Preterm Birth (PTB)</style></keyword><keyword><style  face="normal" font="default" size="100%">Uterocervical Angle Anterior</style></keyword><keyword><style  face="normal" font="default" size="100%">Uterocervical Angle Posterior.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">52-56</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; To determine whether the examination of the uterocervical angle anterior, posterior, cervical length, and combination can be used as a predictor of successful delay in labor in patients with threatened preterm birth (PTB). &lt;strong&gt;Methods:&lt;/strong&gt; This is a prospective cohort analytical observational study of 44 women admitted to our hospital gestational age 28-36 weeks diagnosed with threatened preterm birth. Cervical length, anterior uterocervical angle, and posterior uterocervical angle examinations were performed. Patient then observed for 2x24 hours whether there was a delay in labor or not. If there is a delay, the patient followed until delivery. &lt;strong&gt;Results&lt;/strong&gt;: CL cut off value &amp;gt; 2.66 cm delaying labor for 2x24 hours and &amp;gt; 2.81 cm delaying labor until term. UCA posterior cut off value &amp;lt; 113.2o delaying labor for 2x24 hours and &amp;lt; 107.8o delaying labor until term. Anterior UCA cut off values &amp;lt; 103.2o delaying labor for 2x24 hours and &amp;lt; 93.1o delaying labor until term. Statistical Analysis showed that CL was significant as a single tool for predictor of delayed labor either 2x24 hours or up to term, while posterior and anterior UCA was not. But if this 3 single tools combinate, CL, anterior UCA, and posterior UCA was statistically significant as a predictor of delay in labor either 2x24 hours or until term, with the best predictive value is a combination of CL and posterior UCA of 25.2% for predicting delay of labor 2x24 hours and the combination of CL, posterior, and anterior UCA was 24.6% for predicting delay labor until term. &lt;strong&gt;Conclusion:&lt;/strong&gt; Cervical length ultrasound examination and the combination of CL, anterior UCA, and posterior UCA can be predictors of delayed labor in patients with threatened preterm birth but not for anterior and posterior uterocervical angle as a single tool.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">52</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Qurrata Akyuni&lt;sup&gt;1,*&lt;/sup&gt;, Agus Sulistiyono&lt;sup&gt;1&lt;/sup&gt;, Hermanto Tri Joewono&lt;sup&gt;1&lt;/sup&gt;, Lilik Djuari&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University&amp;nbsp;Dr. Soetomo Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sandy Novryanto Sakati</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Erniwati Ibrahim</style></author><author><style face="normal" font="default" size="100%">Budimawan</style></author><author><style face="normal" font="default" size="100%">Stang</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Maria Kanan</style></author><author><style face="normal" font="default" size="100%">Herawati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Utilization of Rainwater as Consumable Water with Rainwater Harvesting Methods: A Literature Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Consumable</style></keyword><keyword><style  face="normal" font="default" size="100%">Harvesting</style></keyword><keyword><style  face="normal" font="default" size="100%">Rainwater</style></keyword><keyword><style  face="normal" font="default" size="100%">Utilization</style></keyword><keyword><style  face="normal" font="default" size="100%">Water Quality</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1254-1257</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Water demand is expected to increase in all sectors. Rainwater can be a solution to the lack of the clean water crisis. The quality of rainwater harvested is highly dependent on the rainwater harvesting system. &lt;strong&gt;Methods: &lt;/strong&gt;This literature review is a narrative review using sources from the Scopus and Pubmed databases. The keywords used were utilization, rainwater, and rainwater harvesting methods. Of the 30 references identified in the search phase, ten were eligible for inclusion in this review. &lt;strong&gt;Results:&lt;/strong&gt; Harvested rainwater can be used for multiple purposes such as watering plants, washing, bathing, and even cooking if the water quality meets health standards. There are three fundamental components that should be present within the rainwater harvesting system: 1) a rainwater pipe that traps water, e.g., utilizing the shape of the roof surface, 2) a water distribution system, i.e., a system that transports water from the roof to the superficies through a gutter, and 3) a reservoir that stores rainwater such as barrels, tubs, or ponds. &lt;strong&gt;Conclusions:&lt;/strong&gt; Water conservation efforts are needed to meet the demand for water in the face of increasingly limited supply. Harvesting rainwater is one of the methods of water conservation that can be carried out by each household of the community to collect raw rainwater for consumption and use. If rainwater harvesting is practiced in a sustainable manner, it will help maintain water and environmental sustainability, thus supporting the livelihood of present and future generations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1254</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sandy Novryanto Sakati&lt;sup&gt;1,3&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;2,*&lt;/sup&gt;, Erniwati Ibrahim&lt;sup&gt;2&lt;/sup&gt; , Budimawan&lt;sup&gt;2&lt;/sup&gt; , Stang&lt;sup&gt;2&lt;/sup&gt; , Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt; , Maria Kanan&lt;sup&gt;3&lt;/sup&gt; , Herawati&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral student, Public Health Sciences, Hasanudin University Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Public Health, Faculty of Public Health Sciences, Universitas Hasanuddin, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health, Faculty of Public Health Sciences, University of Tompotika, Luwuk Banggai, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lukman La Basy</style></author><author><style face="normal" font="default" size="100%">Djoko Santosa</style></author><author><style face="normal" font="default" size="100%">Retno Murwanti</style></author><author><style face="normal" font="default" size="100%">Triana Hertiani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Uncover Itchy Leaves Ethnomedicine Usage: A Preliminary Study on Characterization and Bioactivity of Laportea Spp</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Characterization</style></keyword><keyword><style  face="normal" font="default" size="100%">Cox-2 inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH radical scavenging activity.</style></keyword><keyword><style  face="normal" font="default" size="100%">Itchy leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Laportea decumana (Roxb.) Wedd</style></keyword><keyword><style  face="normal" font="default" size="100%">Laportea stimulans (L.f.) Gaud</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical profiles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">286-295</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Laportea decumana&lt;/em&gt; (Roxb.) Wedd. and &lt;em&gt;Laportea&lt;/em&gt; stimulans (L.f.) Miq. (Urticaceae) or itchy leaves are endogenous plants from The Maluku Islands, Indonesia, which are used topically as analgesics by local people.&lt;strong&gt; Objective&lt;/strong&gt;: As part of a preliminary investigation on the itchy leaves, this study was conducted to provide information on their macroscopic and microscopic characteristics, phytochemical profiles, and bioactivities according to the ethnomedicinal usages. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The macroscopic examination was carried out on fresh leaves. The microscopic examination was carried out on leaf powder under a light microscope. The phytochemical analyses using TLC were conducted on those crude extracts and fractions. The bioactivity assays were conducted&lt;em&gt; in vitro&lt;/em&gt; as Cox-2 inhibitory and DPPH radical scavenging activities. Results: reveal similar characteristics in the macroscopic and microscopic properties of both &lt;em&gt;Laportea &lt;/em&gt;spp. leaves. Calcium oxalate crystals were observed in&lt;em&gt; L. decumana&lt;/em&gt; but not found in &lt;em&gt;L. stimulans.&lt;/em&gt; Both species have stomata with anisocytic type. More trichomes are found in the leaves of&lt;em&gt; L. decumana,&lt;/em&gt; yet smaller and easily detachable. TLC analyses exhibited slightly different profiles. The crude extracts and fractions at 10 μg/ml showed similar inhibitory percentages on Cox-2. The DPPH scavenging activities of the crude extracts and fractions of&lt;em&gt; L. decumana &lt;/em&gt;showed active moderate activity with an IC50 value &amp;lt; 250 μg/ml, while those of &lt;em&gt;L. stimulans&lt;/em&gt; showed moderate to weak potency with an IC50 value &amp;lt; 500 μg/ml. &lt;strong&gt;Conclusion: &lt;/strong&gt;Further exploration on Laportea spp. pharmacological activity is recommended to provide stronger evidence for its ethnomedicinal usage.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">06</style></accession-num><section><style face="normal" font="default" size="100%">286</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lukman La Basy&lt;sup&gt;1,2&lt;/sup&gt;, Djoko Santosa&lt;sup&gt;3&lt;/sup&gt;, Retno Murwanti&lt;sup&gt;4&lt;/sup&gt;, Triana Hertiani&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmaceutical Sciences Doctoral Study Program, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacy Department, Stikes Maluku Husada, Maluku 97566, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">AF Dibha</style></author><author><style face="normal" font="default" size="100%">S Wahyuningsih</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">VD Kharisma</style></author><author><style face="normal" font="default" size="100%">MH Widyananda</style></author><author><style face="normal" font="default" size="100%">AA Parikesit</style></author><author><style face="normal" font="default" size="100%">MT Sibero</style></author><author><style face="normal" font="default" size="100%">RT Probojati</style></author><author><style face="normal" font="default" size="100%">AAA Murtadlo</style></author><author><style face="normal" font="default" size="100%">JP Trinugroho</style></author><author><style face="normal" font="default" size="100%">TH Sucipto</style></author><author><style face="normal" font="default" size="100%">DDR Turista</style></author><author><style face="normal" font="default" size="100%">I Rosadi</style></author><author><style face="normal" font="default" size="100%">ME Ullah</style></author><author><style face="normal" font="default" size="100%">V Jakhmola</style></author><author><style face="normal" font="default" size="100%">R Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Utilization of Secondary Metabolites in Algae Kappaphycus alvarezii as a Breast Cancer Drug with a Computational Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">K. alvarezii</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Docking.</style></keyword><keyword><style  face="normal" font="default" size="100%">NF kB protein kinase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">536-543</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Breast cancer is one of the worst diseases that affect female people. Long-term treatment with therapy or surgery has a detrimental impact on the patient. The algae &lt;em&gt;Kappaphycus alvarezii&lt;/em&gt; has gotten a lot of interest as a breast cancer medication because it contains chemicals that are expected to be anti-cancer. The objectives of this paper were to see how secondary metabolites in algae interact with the Nuclear Factor- kappaB protein kinase in breast cancer. The ligands and proteins were obtained from the PubChem and PDB websites, respectively. Swiss ADME was then used to assess the Pharmacokinetics and Drug likeness Properties. The last stage involved using molecular docking with PyRx and molecular dynamics to identify the interaction and visualization between the ligand and the target protein. The findings of the test revealed that the maraniol chemical had a superior binding capacity with NF kB protein kinase because it has a chromone group that controls transport efficiently in preventing breast cancer proliferation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">08</style></accession-num><section><style face="normal" font="default" size="100%">536</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;AF Dibha&lt;sup&gt;1&lt;/sup&gt;, S Wahyuningsih&lt;sup&gt;2&lt;/sup&gt;, ANM Ansori&lt;sup&gt;3&lt;/sup&gt;, VD Kharisma&lt;sup&gt;4&lt;/sup&gt;, MH Widyananda&lt;sup&gt;4,5&lt;/sup&gt;, AA Parikesit&lt;sup&gt;6&lt;/sup&gt;, MT Sibero&lt;sup&gt;7&lt;/sup&gt;, RT Probojati&lt;sup&gt;4,8&lt;/sup&gt;, AAA Murtadlo&lt;sup&gt;4&lt;/sup&gt;, JP Trinugroho&lt;sup&gt;9&lt;/sup&gt;, TH Sucipto&lt;sup&gt;10&lt;/sup&gt;, DDR Turista&lt;sup&gt;11&lt;/sup&gt;, I Rosadi&lt;sup&gt;12&lt;/sup&gt;, ME Ullah&lt;sup&gt;13,&lt;/sup&gt; V Jakhmola&lt;sup&gt;14&lt;/sup&gt;, R Zainul&lt;sup&gt;15,16,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Biology, Gadjah Mada University, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Marine Science, Faculty of Fisheries and Marine Science, Universitas Diponegoro, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Faculty of Agriculture, Universitas Kadiri, Kediri, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Life Sciences, Imperial College London, South Kensington Campus, London, UNITED KINGDOM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Department of Chemistry, Mississippi State University, Mississippi State, UNITED STATES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hesham I Elaskary</style></author><author><style face="normal" font="default" size="100%">Omar M Sabry</style></author><author><style face="normal" font="default" size="100%">Asmaa M Khalil</style></author><author><style face="normal" font="default" size="100%">Soheir M El Zalabani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">UPLC-PDA-ESI-MS/MS Profiling of Clerodendrum inerme and Clerodendrum splendens and Significant Activity Against Mycobacterium tuberculosis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Clerodendrum</style></keyword><keyword><style  face="normal" font="default" size="100%">Diterpenoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Iridoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Mycobacterium</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenyl-propanoids</style></keyword><keyword><style  face="normal" font="default" size="100%">UPLC profiling</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1518-1524</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Antibiotic resistance is a major problem that is spreading and increasing while the development of new antibiotics is ceasing. As a result, some bacterial infections that were easily treated previously became untreatable. The antibacterial activity of &lt;em&gt;Clerodendrum inerme&lt;/em&gt; and &lt;em&gt;Clerodendrum splendens &lt;/em&gt;leaves were investigated against Mycobacterium tuberculosis, the widely known multi-drug resistant bacterium. UPLC-PDA-ESI-MS/MS is characterized by high sensitivity, resolution and speed for identification of plant metabolites even the minor ones. The chemical constituents of the leaves of &lt;em&gt;C. inerme &lt;/em&gt;and&lt;em&gt; C. splendens&lt;/em&gt; were investigated by UPLC-PDA-ESI-MS/MS metabolic analysis. &lt;strong&gt;Methods: &lt;/strong&gt;The antibacterial activity of the ethanol extracts of the leaves of the two species under investigation was evaluated against the multi-ethanol drug resistant bacterium &lt;strong&gt;Mycobacterium tuberculosis&lt;/strong&gt; using MABA assay. The methanol extracts of the leaves of &lt;em&gt;C. inerme&lt;/em&gt; and &lt;em&gt;C. splendens&lt;/em&gt; were subjected to comparative UPLC-PDA-ESI-MS/MS analysis. &lt;strong&gt;Results: &lt;/strong&gt;The ethanol extract of C .inerme leaves showed significant antibacterial activity against &lt;strong&gt;Mycobacterium tuberculosis&lt;/strong&gt;, while that of &lt;em&gt;C. splendens&lt;/em&gt; showed moderate activity. The UPLC-PDA-ESI-MS/MS analysis revealed a total of 36 metabolites detected and tentatively identified in the two species under investigation, among them 28 chromatographic peaks were assigned in&lt;em&gt; C. inerme&lt;/em&gt; while only 14 were assigned in these &lt;em&gt;C. splendens.&lt;/em&gt; The main classes of secondary metabolites detected were Phenylpropanoid and, iridoid glycosides, flavonoids, diterpenoids, phenolic acid and fatty acid derivatives. &lt;strong&gt;Conclusion: &lt;/strong&gt;The results of the antibacterial activity and UPLC-PDA-ESI-MS/ MS analysis showed stronger activity and higher number of metabolites for &lt;em&gt;C. inerme&lt;/em&gt; as compared to &lt;em&gt;C. splendens.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1518</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hesham I. Elaskary, Omar M. Sabry*, Asmaa M. Khalil, Soheir M. El Zalabani &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shilu Mathew</style></author><author><style face="normal" font="default" size="100%">Muhammad Faheem</style></author><author><style face="normal" font="default" size="100%">Mohd Suhail</style></author><author><style face="normal" font="default" size="100%">Kaneez Fatima</style></author><author><style face="normal" font="default" size="100%">Govindaraju Archunan</style></author><author><style face="normal" font="default" size="100%">Nargis Begum</style></author><author><style face="normal" font="default" size="100%">Muhammad Ilyas</style></author><author><style face="normal" font="default" size="100%">Esam Azhar</style></author><author><style face="normal" font="default" size="100%">Ghazi Abdullah Damanhouri</style></author><author><style face="normal" font="default" size="100%">Ishtiaq Qadri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Updates on Traditional Medicinal Plants for Hepatocellular Carcinoma</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmaceutical Journals</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbs</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">203-214</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;Hepatocellular carcinoma (HCC) is a major worldwide problem primarily caused by hepatitis B and C virus infection. End stage liver cancer treatment options are limited thus requiring expensive liver transplantation which is not available in many countries. &lt;strong&gt;Methods: &lt;/strong&gt;Several herbal compounds and herbal composite formulas have been studied through &lt;em&gt;in-vitro &lt;/em&gt;and &lt;em&gt;in vivo &lt;/em&gt;as an anti-HCC agent, enhancing our knowledge about their biological functions and targets. In this article, arecent update on the herbal medicine has been provided with reference to liver cancer. &lt;strong&gt;Results:&lt;/strong&gt; For the sake of clarity, the effective herbal compounds, clinical studies of herbal composite formula, cell culture, and animal model studies safety are discussed. The effects of many herbal active compounds of &lt;em&gt;Annona atemoya,&lt;/em&gt; &lt;em&gt;Andrographis paniculata, Boerhaviadiffusa,&lt;/em&gt; &lt;em&gt;Piper longum, Podophyllum&lt;/em&gt; &lt;em&gt;hexandrum, Phyllanthus amarus, &lt;/em&gt;and &lt;em&gt;Terminalia chebula&lt;/em&gt;, and herbal composite formula on autophagy, apoptosis, antioxidant, and inflammation characteristicshave been provided. &lt;strong&gt;Conclusion: &lt;/strong&gt;This will enhance our understanding&amp;nbsp;on the prevention and treatment of HCC by herbal active compounds&amp;nbsp;and herbal composite formulas.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">203</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shilu Mathew&lt;sup&gt;1,2,3&lt;/sup&gt;, Muhammad Faheem&lt;sup&gt;4&lt;/sup&gt;, Mohd Suhail&lt;sup&gt;5&lt;/sup&gt;, Kaneez Fatima&lt;sup&gt;6&lt;/sup&gt;, Govindaraju Archunan&lt;sup&gt;3&lt;/sup&gt;, Nargis Begum&lt;sup&gt;1&lt;/sup&gt;, Muhammad Ilyas&lt;sup&gt;7&lt;/sup&gt;, Esam Azhar&lt;sup&gt;5&lt;/sup&gt;, Ghazi Abdullah Damanhouri&lt;sup&gt;5&lt;/sup&gt; and Ishtiaq Qadri&lt;sup&gt;5&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Postgraduate Department of Biotechnology, Jamal Mohamed College, Tiruchirappalli, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, SAUDI ARABIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Animal Science, Bharathidasan University, Tiruchirappalli, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biosciences, Faculty of Sciences, COMSATS Institute of Information Technology, Islamabad, PAKISTAN.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Biotechnology and Translational Medicine Research, King Fahd Medical Research Center, King Abdul Aziz University, PO Box 80216, SAUDI ARABIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;IQ Institute of Infection and Immunity, Lahore, PAKISTAN.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Botany, Jamal Mohamed College, Tiruchirappalli, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>