<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pallab Kar</style></author><author><style face="normal" font="default" size="100%">Ayodeji O. Oriola</style></author><author><style face="normal" font="default" size="100%">Adebola O. Oyedeji</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Natural Flavonoid Glycoside-Based Zinc Oxide Nanoparticles: Compound Isolation, Nanoparticle Green Synthesis, Characterization, and in vitro Antioxidant, Anti-hyperglycaemic and Anti-inflammatory Effects</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">antihyperglycaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Green synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">natural flavonoid glycosides</style></keyword><keyword><style  face="normal" font="default" size="100%">ZnO Nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">531-541</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Recent advances in effective and efficient drug delivery have favoured the biological applications of phytochemical-based metal oxide nanoparticles (NPs). Objective: This study, therefore, utilized a flavonoid glycoside, Myricitrin (MY), isolated from &lt;em&gt;Eugenia uniflora &lt;/em&gt;as a biogenic substance for the synthesis of zinc oxide nanoparticles (ZnONPs) and evaluated the antioxidant, anti-hyperglycaemic, and anti-inflammatory potentials. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Flavonoid glycoside was isolated from the leaf of &lt;em&gt;E. uniflora&lt;/em&gt; following standard phytochemical techniques for extraction, solvent-partitioning, column chromatography, and thin-layer chromatography. The phytocompound was characterized by NMR and HRESI-MS methods. Zinc oxide NPs were green synthesized using the isolated flavonoid glycoside. The biogenic ZnONPs were characterized using UV-Vis, FESEM, EDX, and XRD techniques. The biological potential of the MY-ZnONPs was based on in vitro analysis. Nitric oxide (NO), H2O2, OH, and O2 - antioxidant methods were used. The anti-hyperglycaemic effect was based on α-amylase and α-glucosidase enzyme inhibition, while the egg albumin denaturation (EAD) method was used to determine the antiinflammatory effect. &lt;strong&gt;Results:&lt;/strong&gt; Flavonoid glycoside was isolated and characterized as myricitrin from &lt;em&gt;E. uniflora&lt;/em&gt;. The MY-ZnONPs were green synthesized as a greyish powder. The UV-Vis absorption peaks at 387 and 415 nm match the characteristic peaks for ZnONPs. The FESEM revealed petal-, irregular-, and spindle-shaped NPs of 30-80 nm size, which tend to agglomerate in clusters and bundles. The EDX analysis showed the elemental weight percentage of Zn and O to be 79.83% and 18.51%, respectively, indicating the successful formation of ZnO nanoparticles. The X-ray diffractogram showed the crystallinity of the NPs at 29.23⁰, 36.25⁰, 51.50⁰, 63.67⁰, 72.06⁰, and 78.90⁰. At 100 μg/mL, the NPs demonstrated a comparable 68% inhibition of O&lt;sub&gt;2&lt;/sub&gt; - to Quercetin, the standard antioxidant. They inhibited EAD in a dose-de pendent manner, having ≥75% inhibition at 200 μg/mL. Finally, they exhibited notable anti-hyperglycaemic properties against α-amylase and α-glucosidase with IC&lt;sub&gt;50&lt;/sub&gt; of 89.24±0.63 and 105.95±0.05 μg/mL, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study has shown MY-ZnONPs as a flavonoid glycoside-based metal oxide nanoparticle with notable antioxidant, anti-diabetic, and anti-inflammatory activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">531</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Pallab Kar&lt;sup&gt;1,*&lt;/sup&gt;, Ayodeji O. Oriola&lt;sup&gt;2,*&lt;/sup&gt;, Adebola O. Oyedeji&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;African Medicinal Flora and Fauna Research Niche Area, Walter Sisulu University Nelson Mandela Drive, P/Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemical and Physical Sciences, Walter Sisulu University, Nelson Mandela Drive, P/ Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ariunaa Erdene</style></author><author><style face="normal" font="default" size="100%">Amarjargal Baldandorj</style></author><author><style face="normal" font="default" size="100%">Shagdarsuren Dashjamts</style></author><author><style face="normal" font="default" size="100%">Khaliunaa Baasanjav</style></author><author><style face="normal" font="default" size="100%">Bold Sharav</style></author><author><style face="normal" font="default" size="100%">Selenge Erdenechimeg</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">New Studies on Drug Discovery for Cardiovascular Diseases from “Beautiful Wondrous Eye Ornament” by Jambaldorj</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ancient medical books</style></keyword><keyword><style  face="normal" font="default" size="100%">Cardiovascular diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">Jambaldorj</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">323-326</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This research is to clear the information of the ancient medical books written by toin Jambaldorj, who wrote about some herbal medicines used to treat cardiovascular diseases, and their taste, potency, and quality. Toin Jambaldorj. Gso byed bdud rtsi'i 'khrul med ngos 'dzin bzo rig me long du rnam par shar ba mdzes mtshar mig rgyan zhes bya ba bzhugs so. Wooden printing block with Tibetan script. Methods of textual analysis for ancient books and checklist methods were used in the study. A prominent representative of traditional Mongolian medicine, Toin Jambaldorj, wrote his book “Beautiful Wondrous Eye Ornament” between 1817 and 1823. He used dozens of Indian Ayurvedic, Chinese, and Tibetan medical works of that time to write this book. He also extensively used the Mongolians’ medical heritage. Therefore, this book is considered the most reliable book on pharmacognosy. Toin Jambaldorj's book “Beautiful Wondrous Eye Ornament” lists 9 herbal medicines used for cardiovascular diseases. The names of some herbal medicines are written in Mongolian, Chinese, Tibetan, Manchu, and Sanskrit, further evidence that the book was written in many languages and from many different sources&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">323</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ariunaa Erdene&lt;sup&gt;1&lt;/sup&gt;, Amarjargal Baldandorj&lt;sup&gt;1,2*&lt;/sup&gt;, Shagdarsuren Dashjamts&lt;sup&gt;1&lt;/sup&gt;, Khaliunaa Baasanjav&lt;sup&gt;3&lt;/sup&gt;, Bold Sharav&lt;sup&gt;1,3&lt;/sup&gt;, Selenge Erdenechimeg&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Mongolian University of Pharmaceutical Sciences, PO-37, Box-59, Ulaanbaatar 18080, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;BUNDA Clinic, Peace Avenue 107, Ulaanbaatar 16000, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;“Ach” Medical University, Peace Avenue, Ulaanbaatar 18101, MONGOLIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kukuh Dwiputra Hernugrahanto</style></author><author><style face="normal" font="default" size="100%">Naufaldy Rifqiaulia Noerda</style></author><author><style face="normal" font="default" size="100%">Jifaldi Afrian Maharaja Dinda Sedar</style></author><author><style face="normal" font="default" size="100%">Lukas Widhiyanto</style></author><author><style face="normal" font="default" size="100%">Dwikora Novembri Utomo</style></author><author><style face="normal" font="default" size="100%">Djoko Santoso</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Natural Cartilage-Derived Scaffolds for 3D Mesenchymal Stem Cell Culture: Promoting Chondrogenesis and Modulating Secretome Composition</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cartilage</style></keyword><keyword><style  face="normal" font="default" size="100%">Culture Technique</style></keyword><keyword><style  face="normal" font="default" size="100%">Secretome</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Three-Dimensional</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1365-1372</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The regenerative potential of stem cells lies in their secretome, a collection of signaling molecules whose composition is shaped by the cellular microenvironment and external stimuli. To enhance cartilage regeneration, a 3D culture system using a natural cartilage scaffold has been developed to create a more chondrogenic secretome. This study investigates the chondrogenic differentiation of mesenchymal stem cells (MSCs) cultured in a decellularized bovine cartilage scaffold and analyzes the resulting secretome's composition. &lt;strong&gt;Methods: &lt;/strong&gt;This study employed a randomized time series design to examine MSCs chondrogenic differentiation. A control group was cultured in standard 2D conditions, while two experimental groups were cultured in either 2D medium supplemented with chondrocyte differentiation medium (positive control) or a 3D decellularized bovine cartilage scaffold. The study hypothesized that the 3D culture would promote chondrogenesis at least as effectively as the positive control. Key chondrogenic markers were evaluated at various time points.&lt;strong&gt; Results: &lt;/strong&gt;Statistical analysis revealed significant differences in marker expression between the experimental and control groups. SOX-9 and aggrecan were elevated in both experimental groups. The 3D group showed higher RUNX-2 expression and the highest Coll-2 expression at later time points. Additionally, growth factor analysis showed the 3D group had the highest levels of IGF-1 and FGF-2 towards the end of the study. &lt;strong&gt;Conclusion: &lt;/strong&gt;3D culture of MSCs in a bovine cartilage scaffold enhances chondrogenic differentiation and produces a secretome with comparable chondrogenic potential to traditional 2D culture with differentiation medium, suggesting its promise for cartilage regeneration.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1365</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kukuh Dwiputra Hernugrahanto&lt;sup&gt;1,2,3&lt;/sup&gt;, Naufaldy Rifqiaulia Noerda&lt;sup&gt;4&lt;/sup&gt;, Jifaldi Afrian Maharaja Dinda Sedar&lt;sup&gt;2,3&lt;/sup&gt;, Lukas Widhiyanto&lt;sup&gt;2,3&lt;/sup&gt;, Dwikora Novembri Utomo&lt;sup&gt;2,3&lt;/sup&gt;, Djoko Santoso&lt;sup&gt;5,6*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Orthopaedic and Traumatology, Dr Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Siti Khodijah Hospital, Sidoarjo, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Internal Medicine, Dr Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prafa Alif Rahmawan</style></author><author><style face="normal" font="default" size="100%">Yetti Hernaningsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Natural Compounds in Clot Waveform Analysis and D-Dimer Modulation: Implications for COVID-19 Diagnosis and Prognosis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Activated partial thromboplastin time</style></keyword><keyword><style  face="normal" font="default" size="100%">Clot waveform analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">D-dimer</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1373-1378</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; Patients diagnosed with coronavirus disease (COVID-19) may develop hypercoagulopathy. A thromboelastogram can detect hypercoagulopathy, but it is not commonly available in all healthcare facilities. Understanding the clot waveform analysis (CWA) parameters of the CS-2500 coagulation analyzer in patients diagnosed with COVID-19 may help determine whether it can serve as an alternative. &lt;strong&gt;Methods:&lt;/strong&gt; This study measured the amounts of activated partial thromboplastin time (aPTT)-based CWA, aPTT, plasma prothrombin time (PPT), and D-dimer using the CS-2500 autoanalyzer in 177 patients confirmed with COVID-19 and 110 patients without COVID-19. Retrospective data collection was conducted using electronic medical records. COVID-19 and non-COVID-19 were distinguished by the SARS-COV-2 PCR results.&lt;strong&gt; Results: &lt;/strong&gt;Substantial differences were observed in the aPTT-based CWA parameters, including maximum coagulation velocity (Vmax), maximum coagulation acceleration (Amax), and maximum coagulation deceleration (Dmax) (p = 0.03, p = 0.03, and p = 0.02), between the COVID-19 and non-COVID-19 groups but not between survivors and non-survivors. Additionally, a substantial difference was identified in the D-dimer between the two groups (p = 0.002 and p &amp;lt; 0.001). The difference in D-dimer between both groups could be explained by the fact that non-survivors have a more prominent hypercoagulable state. &lt;strong&gt;Conclusions: &lt;/strong&gt;While the D-dimer may be a better indicator of mortality in COVID-19 patients, the aPTT-based CWA characteristics may be more helpful in differentiating between COVID-19 and non-COVID-19 patients. Further investigations on treatment interference and the specificity of this method to predict hypercoagulable states are warranted.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1373</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prafa Alif Rahmawan&lt;sup&gt;1&lt;/sup&gt;, Yetti Hernaningsih&lt;sup&gt;2,3*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Student of Specialist, Clinical Pathology Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Pathology, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bayu Aditya</style></author><author><style face="normal" font="default" size="100%">Manggala Pasca Wardhana</style></author><author><style face="normal" font="default" size="100%">Tauhid Islamy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephrogenic Diabetes Insipidus or Bartter Syndrome? A Dilemma of Refractory Hypokalemia in Pregnancy: A Case Report from Soedono Regional Public Hospital in Madiun</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ADH</style></keyword><keyword><style  face="normal" font="default" size="100%">Bartter Syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes insipidus</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypokalemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">495-497</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Hypokalemia is a rare condition in pregnant women. Muscle weakness and life-threatening heart damage can occur if the baseline condition is not treated, especially if it recurs and persists. The differential diagnosis in recurrent hypokalemia includes nephrogenic diabetes insipidus, characterized by the kidneys' inability to respond to vasopressin to concentrate urine, or Bartter syndrome, a tubulopathy resulting from a rare genetic mutation affecting the loop of Henle, leading to potassium wasting. A 24-year-old primigravida at 35/36 weeks gestation presented with refractory hypokalemia, indicative of diabetes insipidus or a differential diagnosis of Bartter syndrome. The patient complained of limb weakness combined with polydipsia, polyuria, and a history of periodic paralysis due to severe hypokalemia since 2016. She consistently took potassium supplements and monitored her potassium levels. Since becoming pregnant in November 2021, the patient has been hospitalized three times due to limb weakness, with the lowest serum potassium level recorded at 1.6. Throughout her pregnancy, fetal growth and development remained within normal limits, and her blood pressure ranged from 100-120/60-80. In patients with limb weakness, evaluating serum potassium levels is crucial. In this case, the suspicion of nephrogenic diabetes insipidus could not be confirmed due to the unavailability of antidiuretic hormone (ADH) tests. Bartter syndrome, although rarely encountered, should be considered in patients with recurrent hypokalemia. The challenge in Indonesia lies in the lack of specific gene examinations for diagnosis, making diagnostics relatively difficult. Our recommendation for cases like this is to conduct ADH examinations and thoroughly investigate refractory hypokalemia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Case Report</style></work-type><section><style face="normal" font="default" size="100%">495</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bayu Aditya&lt;sup&gt;1*&lt;/sup&gt;, Manggala Pasca Wardhana&lt;sup&gt;2,3&lt;/sup&gt;, Tauhid Islamy&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Resident the Department of Obstetrics and Gynecology, Dr. Soetomo Regional Public Hospital/ Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medical Staff Group (SKM) of the Department of Obstetrics and Gynecology, Dr. Soetomo Regional Public Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Fetomaternal Staff of the Department of Obstetrics and Gynecology, Dr. Soedono Regional Public Hospital, Madiun, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kassim SA Al Neaimy</style></author><author><style face="normal" font="default" size="100%">Maes MK Alkhyatt</style></author><author><style face="normal" font="default" size="100%">Israa A Jarjess</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">New Insights of Oxidative Stress and Thalassemia May Lead to Antioxidant Therapy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Thalassemia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">202-204</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Because of chronic hemolysis, thalassemic patients are under oxidative cell injury caused by secondary iron overload. This provokes oxidative damage to the cellular membranes of organs that accumulate excess iron. Several researchers studied the oxidative stress in patients with thalassemia during chelation therapy and repeated blood transfusion periods, and they found that β-thalassemia patients are under oxidative stress, but they did not focus on before the chelating therapy period. &lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the total antioxidant capacity (TAOC) and oxidative stress (OS) in newly diagnosed patients with β-thalassemia before chelating therapy. &lt;strong&gt;Methodology:&lt;/strong&gt; In the present case-control study, twenty patients newly diagnosed with β-thalassemia before receiving chelating agents, and another 30 healthy individuals, sex-matched with patients, considered as a control, were included in the study. Total antioxidant capacity (TAOC) and Malondialdehyde (MDA) were assessed in the studied groups.&lt;strong&gt; Results: &lt;/strong&gt;The TAOC values of the thalassemic group (35±0.11 u/ml ) were significantly (p&amp;lt;0.001) lower than that of the control group (79±7.2 u/ml). MDA values of the thalassemic group (7.9 ±2.35nmol/l) were significantly (p&amp;lt;0.001) more than that of the control group (0.57±0.25 nmol/l). &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study demonstrated that patients with β thalassemia have decreased values of TAOC, and increased values of MDA when compared with the control group.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">202</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Kassim SA Al Neaimy&lt;sup&gt;1,&lt;/sup&gt;*, Maes MK Alkhyatt&lt;sup&gt;2&lt;/sup&gt;, Israa A Jarjess&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, College of Medicine, Nineveh University, Mosul, IRAQ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, College of Pharmacy, Nineveh University, Mosul, IRAQ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Thalassemia Center, Ibn Alatheer Teaching Hospital, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammed Saarti</style></author><author><style face="normal" font="default" size="100%">Musab M Khalaf</style></author><author><style face="normal" font="default" size="100%">Zeina A. Althanoon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Non-Nutritive Sweeteners Modulated Creatinine and Urea Levels in White Albino Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acesulfame-K</style></keyword><keyword><style  face="normal" font="default" size="100%">Artificial Sweeteners</style></keyword><keyword><style  face="normal" font="default" size="100%">Aspartame</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-nutritive sweeteners</style></keyword><keyword><style  face="normal" font="default" size="100%">Saccharine</style></keyword><keyword><style  face="normal" font="default" size="100%">Sucralose</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">422-425</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Artificial sweeteners, also known as nonnutritive sweeteners have many benefits like low calories count. It is frequently used for reducing weight, controlling blood sugar levels and decreasing the chances of dental decay. This study evaluated the effects of NNS in the kidney function. Using the blood sample of the albino rats, the level of creatinine and urea was calculated after the use of NNS for 3 weeks. 70 rats were equally divided into 7 groups. The groups were given Stevia 200mg/kg/day, 10% solution of sucrose, Sucralose 3g/kg/day, Saccharine, Aspartame 250mg/kg/day and Acesulfame-k 250mg/kg/day respectively. In the controlled group, distilled water was used as a placebo. The results indicated that saccharin and aspartame both caused the urea to increase to 37±0.5 mg/dl from initial 30±1.5mg/dl and acesulfame-k represented the most increase in the urea, which elevated the levels from 30 mg/dl to 38±1.5 mg/dl. Additionally, saccharine and aspartame increased the creatinine levels from from 0.1 to 0.85±0.05 mg/ dl and sucralose elevated the level of creatinine from 0.1 mg/dl to 1.3±0.2 mg/dl. In the stevia group, the results remained the same as in the controlled group. This indicates the nephrotoxic effects of NNS and proves Stevia safe for the daily use as an alternative.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">422</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Mohammed Saarti, Musab M Khalaf, Zeina A. Althanoon*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Hamdan</style></author><author><style face="normal" font="default" size="100%">Priya Nugraha</style></author><author><style face="normal" font="default" size="100%">Pramitha Nayana Librata</style></author><author><style face="normal" font="default" size="100%">Cindy Cecilia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nonmotoric Symptoms Scale (NMSS) Validity and Reliability Test in Patients with Parkinson's Disease in Dr. Soetomo General Hospital, Surabaya, Indonesia: A Questioner Validation Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nonmotoric Symptoms Scale</style></keyword><keyword><style  face="normal" font="default" size="100%">Parkinson’s disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Validation</style></keyword><keyword><style  face="normal" font="default" size="100%">Validity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">316-320</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Nonmotor symptoms are common but less reported in Parkinson's disease. it’s the cause of decreased quality of life and disability in many patients with Parkinson's disease compared to the motor symptom. Our study aimed to translate the original English-language version of the nonmotor symptom scale (NMSS) into the Indonesian version of the NMSS. And also to evaluate its validity and reliability for use in Indonesian-speaking Parkinson's disease patients. This for better and valid usage of NMSS scale in the Indonesian patient and health care provider &lt;strong&gt;Material and Method: &lt;/strong&gt;This was descriptive-analytic study. Cross-cultural adaptation of NMSS and psychometric analysis of the Indonesian version of NMSS was carried out from 2 Teaching Hospital centers in Surabaya, East Java. Several other scales were also examined, including MMSE, ESS, BDI, and Scopa-Aut. A reliability test was performed using Alpha Cronbach.&lt;strong&gt; Results:&lt;/strong&gt; A total of 35 patients were included in this study. the average age was 64.03±12.92 with the female sex 42.9% (n=15) and the male 57.1% (n=20), and Hoehn and Yahr stage II 57.1% (n=20). The total average NMSS is 11.64. The validity of contents and constructs of the NMSS on each domain has been proven valid. Internal reliability of internal consistency in these tools with an alpha Cronbach value of 0.836. Each domain correlates with several other scores including MMSE, BDI, ESS, and Scopa-aut. &lt;strong&gt;Conclusion:&lt;/strong&gt; The Indonesian version of NMSS has good validity and reliability in assessing nonmotor symptoms in Parkinson's disease patients in Indonesia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">316</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Hamdan*, Priya Nugraha, Pramitha Nayana Librata, Cindy Cecilia&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Airlangga University – Dr. Soetomo General Academic Teaching Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sarah S. Ismael</style></author><author><style face="normal" font="default" size="100%">Noor Ahmed M. Waheed</style></author><author><style face="normal" font="default" size="100%">Seema Mahmood Kasim</style></author><author><style face="normal" font="default" size="100%">Yasser Fakri Mustafa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel Coumarin-Indole Hybrids as Cytotoxic Candidates:  Synthesis and Antiproliferative Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Coumarin</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Indole</style></keyword><keyword><style  face="normal" font="default" size="100%">Michael addition</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1105-1111</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Cancer is regarded as a nightmare for humanity and a challenging task for medical professionals. Twelve hydrides &lt;strong&gt;(2a-2l)&lt;/strong&gt;, made of trifunctionalized coumarin and various substituted indoles, were created in an effort to realize the hope of a cancer cure. The 4,5-dimethoxysalicylaldehyde and ethyl acetoacetate were combined in a Knoevenagel reaction to create the coumarin component. The construction of the indole component involved converting various aminoindoles through diazotization and Sandmeyer reactions to twelve substituted indoles &lt;strong&gt;(1a-1l)&lt;/strong&gt;. These two components were combined through a Michael addition reaction to create the desired hybrids. Investigating their spectra released from various spectroscopical instruments allowed researchers to determine the 2D molecular frameworks of these hybrids. Studying the survival of nine tumor cell types after treatment with the synthesized hybrids enabled researchers to estimate there in vitro impact as cytotoxic candidates. By checking the cell viability using an MTT marker, it was possible to see that this effect was antiproliferative. The cytotoxicity measurements, IC50 scores, revealed a number of intriguing facts. To start, the synthetic hybrids displayed a relatively similar cytotoxic pattern against the cancerous cell lines under investigation. Second, compared to hybrids with chloride, hydroxyl, or methoxy substituents, fluorinated hybrids are more toxic to cancerous cells. Finally, hybrids with indole substituted at position-6 &lt;strong&gt;(2i-2l) &lt;/strong&gt;have the highest cytotoxicity among those with indole functionalized at position-4 &lt;strong&gt;(2a-2d)&lt;/strong&gt; or position-5 &lt;strong&gt;(2e-2h)&lt;/strong&gt;. From these facts, the authors concluded that hybrids with indole substituted at position-4 can represent potential candidates as antiproliferative applicants. Moreover, hybrid &lt;strong&gt;2i &lt;/strong&gt;may serve as a valuable model for creating potent anti-breast cancer therapies.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1105</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sarah S. Ismael*, Noor Ahmed M. Waheed, Seema Mahmood Kasim, Yasser Fakri Mustafa&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hebert Adrianto</style></author><author><style face="normal" font="default" size="100%">Heny Arwati</style></author><author><style face="normal" font="default" size="100%">Sri Subekti</style></author><author><style face="normal" font="default" size="100%">Etik Ainun Rohmah</style></author><author><style face="normal" font="default" size="100%">Reviany Vibrianita Nidom</style></author><author><style face="normal" font="default" size="100%">Setyarina Indrasari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel Point Mutations of the ace-1 Gene of Aedes aegypti Larva Treated with Methanolic Extract of Citrus hystrix</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ace-1 gene</style></keyword><keyword><style  face="normal" font="default" size="100%">Aedes aegypti</style></keyword><keyword><style  face="normal" font="default" size="100%">Citrus hystrix</style></keyword><keyword><style  face="normal" font="default" size="100%">Point mutation.</style></keyword><keyword><style  face="normal" font="default" size="100%">Sequence</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">307-315</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The mosquito species of &lt;em&gt;Ae. aegypti&lt;/em&gt; is a vector of arthropod-borne diseases such as dengue haemorrhagic fever. Acetylcholinesterase (AChE) enzyme in &lt;em&gt;Ae. aegypti&lt;/em&gt; that encoded by the ace-1 gene. Damage in the ace-1 gene as target of insecticide lead to the loss of the normal structure and function of AChE. However, damage in the ace-1 gene remains uncharacterised. The main aim of this study was to find out the point mutations of ace-1 gene in &lt;em&gt;Ae. aegypti&lt;/em&gt; larvae treated with methanolic extract of Citrus hystrix leaves.&lt;strong&gt; Method:&lt;/strong&gt; This experiment using a completely randomized design with two treatment groups. A container containing lethal concentration 50 of methanolic extract of &lt;em&gt;C. hystrix le&lt;/em&gt;aves, and a control group containing only water with 0.5% Tween-20. Each group contained 50 third instar larvae of &lt;em&gt;Ae. aegypti&lt;/em&gt;, and each group was repeated four times. Observation was performed for 24 h for the number of survived and dead larvae. Survived and dead larvae were collected prior to the DNA extraction, PCR, electrophoresis, and sequencing. The sequences of those two groups were then compared to determine the point mutations using genetyx ver 12. &lt;strong&gt;Results:&lt;/strong&gt; The PCR products of both groups showed clear bands of 500-600 bp long. Furthermore, the presence of the mutation was confirmed by sequencing the PCR product of ace-1 between each treatment group. The survived larva in the extract-treated group showed more point mutation compared with that of dead larvae. &lt;strong&gt;Conclusions:&lt;/strong&gt; This first report indicated that many mutations in the form of deletions and insertions in nitrogenous bases and different amino acid variations of the ace-1 gene of third instar larvae of &lt;em&gt;Ae. aegypti &lt;/em&gt;after 24 h treated with methanolic extract of C. hystrix leaves than those in control group.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">307</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Hebert Adrianto&lt;sup&gt;1,2&lt;/sup&gt;, Heny Arwati&lt;sup&gt;3,*&lt;/sup&gt;, Sri Subekti&lt;sup&gt;4,5&lt;/sup&gt;, Etik Ainun Rohmah&lt;sup&gt;4&lt;/sup&gt;, Reviany Vibrianita Nidom&lt;sup&gt;6&lt;/sup&gt;, Setyarina Indrasari&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of Medicine, Universitas Ciputra, Surabaya 60219, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Entomology, Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Fisheries and Marine, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Professor Nidom Foundation, Surabaya 60115, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Syeftyan Muhammad Ali Hamami</style></author><author><style face="normal" font="default" size="100%">Michelle Fai</style></author><author><style face="normal" font="default" size="100%">Ahmad Fariduddin Aththar</style></author><author><style face="normal" font="default" size="100%">M Nizam Zulfi Zakaria</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Nikolai Maksimiuk</style></author><author><style face="normal" font="default" size="100%">Nataliya Kulmakova</style></author><author><style face="normal" font="default" size="100%">Evgeniya Latynina</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Oski Illiandri</style></author><author><style face="normal" font="default" size="100%">Khoirun Nisyak</style></author><author><style face="normal" font="default" size="100%">Ernarisa Fitri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nano Transdermal Delivery Potential of Fucoidan from Sargassum sp. (Brown Algae) as Chemoprevention Agent for Breast Cancer Treatment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Fucoidan</style></keyword><keyword><style  face="normal" font="default" size="100%">Nano transdermal</style></keyword><keyword><style  face="normal" font="default" size="100%">Sargassum sp. .</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">789-795</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Conventional chemotherapy substances are associated with mild to severe side effects that affect both healthy and cancer cells. It is presumed to improve therapeutic efficacy in coexistence reducing chemotherapy’s side effects. Fucoidan is an anticancer bioactive compound derived from &lt;em&gt;Sargassum sp&lt;/em&gt;. that has low cytotoxic activity. The purpose of this study was to explore the effectiveness of anticancer activities of fucoidan from &lt;em&gt;Sargassum sp.&lt;/em&gt; against breast cancer then analyze the suitability of nano transdermal patch of fucoidan and blueprint the long-term research design of nano transdermal patch as a chemoprevention agent in the chemotherapeutic management of breast cancer. This research was performed through a literature study and &lt;em&gt;in silico&lt;/em&gt; study by imposing carbonic anhydrase IX (CA IX) as a marker of hypoxia and metastatic state of cancer cells. The results showed that the fucoidan from &lt;em&gt;Sargassum sp&lt;/em&gt;. effectively induced apoptosis and prevented metastasis of breast cancer cells through the Bcl-2, Bcl-w, and bad pathways. Fucoidan, in addition, was predicted to inhibit CA IX by Glu4 Glu5, Leu7, Pro8, and Asp6 residues. Therefore, the delivery of fucoidan is favored to have a local effect on the site of breast cancer cells by nano transdermal patch preparations using fucoidan nanoparticle polymer. Further nano transdermal patch development as a treatment for breast cancer is suggested through the stages of formulation optimization, optimum formula activity testing, patent filing, and distribution in health services.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">789</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Syeftyan Muhammad Ali Hamami&lt;sup&gt;1&lt;/sup&gt;, Michelle Fai&lt;sup&gt;1&lt;/sup&gt;, Ahmad Fariduddin Aththar&lt;sup&gt;1&lt;/sup&gt;, M Nizam Zulfi Zakaria&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;2,3&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;3&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;4&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;5&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;1,3,&lt;/sup&gt; Dora Dayu Rahma Turista&lt;sup&gt;6&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;7,8,9&lt;/sup&gt;, Nikolai Maksimiuk&lt;sup&gt;10&lt;/sup&gt;, Nataliya Kulmakova&lt;sup&gt;11&lt;/sup&gt;, Evgeniya Latynina&lt;sup&gt;11&lt;/sup&gt;, ANM Ansori&lt;sup&gt;12&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;13,14,*&lt;/sup&gt;, Riso Sari Mandeli &lt;sup&gt;15&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;16&lt;/sup&gt;, Oski Illiandri&lt;sup&gt;17&lt;/sup&gt;, Khoirun Nisyak&lt;sup&gt;18&lt;/sup&gt;, Ernarisa Fitri&lt;sup&gt;19&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Life Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biology Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology Education, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Scientific Research, Russian State Agrarian University Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Institute of Medical Education, Yaroslav-the-Wise Novgorod State University, Velikiy Novgorod, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Veterinary Medicine, Russian State Agrarian University - Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Department of Biomedicine, School of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Department of Pharmacy, Faculty of Public Health, Universitas Anwar Medika, Sidoarjo, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;19&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dian Samudra</style></author><author><style face="normal" font="default" size="100%">Widodo</style></author><author><style face="normal" font="default" size="100%">Nunuk Mardiana</style></author><author><style face="normal" font="default" size="100%">Artaria Tjempakasari</style></author><author><style face="normal" font="default" size="100%">Pranawa</style></author><author><style face="normal" font="default" size="100%">Aditiawardana</style></author><author><style face="normal" font="default" size="100%">Anny Setijo Rahaju</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephrotic Syndrome with Focal Segmental Glomerulosclerosis Histological Feature: A Case Report</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Focal segmental glomerulosclerosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephrotic syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Renal biopsy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">459-461</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Nephrotic syndrome is a clinical syndrome of heavy proteinuria and hypoalbuminemia or hypoproteinemia. Renal biopsy is fundamental to assess not only the type but also the degree of disease activity. The overall prognosis and response to treatment often depend on the severity of histological lesions and their reversibility.&lt;sup&gt;1,2&lt;/sup&gt; &lt;strong&gt;Case Presentation: &lt;/strong&gt;An eighteen years old man with nephrotic syndrome and planned for a kidney biopsy. This case showed a patient with swollen face (especially on the cheek). On Biopsy results showing the glomerulus proliferation of cells and mesangeal matrix, adhesions in (50%) glomerulus, focal sclerosis in some glomeruli, erythrocyte cells visible in the urinary space and thickening of the basement membrane in some glomeruli, partially atrophic tubules, visible erythrocytes in the tubular lumen. &lt;strong&gt;Conclusion:&lt;/strong&gt; An eighteen years old man with nephrotic syndrome with cushing syndrome and hypokalemia who had a renal biopsy. The histological feature from the renal biopsy was focal segmental glomerulosclerosis. The underlying cause of FSGS is still unclear. Assessing the diagnosis and etiology become important to direct the subsequent clinical approach and therapy&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Case Report</style></work-type><accession-num><style face="normal" font="default" size="100%">15</style></accession-num><section><style face="normal" font="default" size="100%">459</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dian Samudra&lt;sup&gt;1,*&lt;/sup&gt;, Widodo&lt;sup&gt;2&lt;/sup&gt;, Nunuk Mardiana&lt;sup&gt;2&lt;/sup&gt;, Artaria Tjempakasari&lt;sup&gt;2&lt;/sup&gt;, Pranawa&lt;sup&gt;2&lt;/sup&gt;, Aditiawardana&lt;sup&gt;2&lt;/sup&gt;, Anny Setijo Rahaju&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Internal Medicine Department, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Internal Medicine Department, Faculty of Medicine, Universitas Airlangga, General Teaching Hospital Dr. Soetomo, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Pathology Anatomy Department, Faculty of Medicine, Universitas Airlangga, General Teaching Hospital Dr. Soetomo, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siordia-Reyes Georgina A</style></author><author><style face="normal" font="default" size="100%">Cornejo-Garrido Jorge</style></author><author><style face="normal" font="default" size="100%">Jiménez-Arellanes M. Adelina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephro- and hepatoprotective effect of Rosmarinus officinalis against damage induced with antiTB drugs using a chronic model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antitubercular drug</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Rosmarinus officinalis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">722-729</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Nephro- and hepatoprotector effect of MeOH extract from &lt;em&gt;R. officinalis&lt;/em&gt; against the liver and kidney damage caused by the mixture of RIF:INH:PZA, using a chronic&lt;em&gt; in vivo&lt;/em&gt; model are described. MeOH extract (EMRO) was prepared by maceration process and was administered by oral via during 91 days in male Balb/C mice with RIF:INH:PZA-induced renal/liver damage, using silymarin (SIL) as a positive control. EMRO (250 mg/kg) favoured body weight gain respect to the antiTB group, this gain was better than that shown by the SIL. The AST and ALT values of the group that received the EMRO extract and SIL were similar to that the control group and low compared to the group antiTB with liver damage. In addition, the GPx, CAT and POx values of the group treated with the EMRO were similar to that the control group. In the liver histological analysis, no significant alteration was observed; however, a severe nephritis was observed in anti-TB group (II) and this effect was less in groups III (antiTB/SIL) and IV (antiTB/EMRO). MeOH extract enhances body weight gain and primarily protects the kidney and liver from damage caused by the antiTB drug mixture when was administered for 91 days.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">722</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siordia-Reyes Georgina A&lt;sup&gt;1&lt;/sup&gt;, Cornejo-Garrido Jorge&lt;sup&gt;2&lt;/sup&gt;, Jiménez- Arellanes M. Adelina&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Patología, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN-SXXI), Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtémoc 330, Col. Doctores, 06720, Ciudad de México (CDMX), MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratorio de Biología Celular y Productos Naturales, Escuela Nacional de Medicina y Homeopatía (ENMH), Instituto Politécnico Nacional, Guillermo Massieu Helguera 239, Col. La Escalera, Del. Gustavo A. Madero, 07320 CDMX, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Unidad de Investigación Médica (UIM) en Farmacología, UMAE Hospital de Especialidades, CORSE 2º piso, CMN-SXXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, 06729, CDMX, MEXICO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nguyen Van Chuyen</style></author><author><style face="normal" font="default" size="100%">Nguyen Hong Son</style></author><author><style face="normal" font="default" size="100%">Pham Van Hien</style></author><author><style face="normal" font="default" size="100%">Dang Truong Giang</style></author><author><style face="normal" font="default" size="100%">Ho Ba Ngoc Minh</style></author><author><style face="normal" font="default" size="100%">Ngo Thi Tuyet Mai</style></author><author><style face="normal" font="default" size="100%">Chu Van Men</style></author><author><style face="normal" font="default" size="100%">Ho Anh Son</style></author><author><style face="normal" font="default" size="100%">Vu Binh Duong</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A New Ursane-Type Triterpene from the Fermented Shallot Allium Ascalonicum</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">24-Acetonideclethric acid</style></keyword><keyword><style  face="normal" font="default" size="100%">3</style></keyword><keyword><style  face="normal" font="default" size="100%">Allium ascalonicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">01-07</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;3,24-acetonideclethric acid &lt;strong&gt;(1), &lt;/strong&gt;a new ursane-type triterpene, and four known compounds including ursolic acid &lt;strong&gt;(2),&lt;/strong&gt; randiasaponin IV &lt;strong&gt;(3),&lt;/strong&gt; ilekudinoside W &lt;strong&gt;(4)&lt;/strong&gt; and (25S)-1β,3β,24β- trihydroxyspirost-5-en 1-O-α-L-rhamnopyranosyl-(1→2)- α-L-arabinopyranoside &lt;strong&gt;(5), &lt;/strong&gt;and were isolated from the fermented shallot &lt;em&gt;Allium ascalonicum&lt;/em&gt;. Their structures were determined by analysis of HR-ESI-MS, NMR spectral data, as well as comparison with those reported in the literature. All of the saponins (3-5) exhibited antimicrobial activity against three strains &lt;em&gt;Staphylococcus aureus, Escherichia coli,&lt;/em&gt; and &lt;em&gt;Candida albicans &lt;/em&gt;with IC&lt;sub&gt;50&lt;/sub&gt; values in the range from 89.49 ± 2.24 to 95.71 ± 3.86 μM.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">01</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nguyen Van Chuyen#, Nguyen Hong Son#, Pham Van Hien, Dang Truong Giang, Ho Ba Ngoc Minh, Ngo Thi Tuyet Mai, Chu Van Men, Ho Anh Son*, Vu Binh Duong*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Vietnam Military Medical University, 160 Phung Hung, Ha Dong District, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;#These authors contributed equally to this work.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arif Nur Muhammad Ansori</style></author><author><style face="normal" font="default" size="100%">Amaq Fadholly</style></author><author><style face="normal" font="default" size="100%">Annise Proboningrat</style></author><author><style face="normal" font="default" size="100%">Yulanda Antonius</style></author><author><style face="normal" font="default" size="100%">Suhailah Hayaza</style></author><author><style face="normal" font="default" size="100%">Raden Joko Kuncoroningrat Susilo</style></author><author><style face="normal" font="default" size="100%">Bilqis Inayatillah</style></author><author><style face="normal" font="default" size="100%">Mada Triandala Sibero</style></author><author><style face="normal" font="default" size="100%">Sin War Naw</style></author><author><style face="normal" font="default" size="100%">Gabrielle Ann Villar Posa</style></author><author><style face="normal" font="default" size="100%">Teguh Hari Sucipto</style></author><author><style face="normal" font="default" size="100%">Soegen Soegijanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel Antiviral Investigation of Annona squamosa Leaf Extract against the Dengue Virus Type-2: In vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annona squamosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiviral activity</style></keyword><keyword><style  face="normal" font="default" size="100%">DENV-2</style></keyword><keyword><style  face="normal" font="default" size="100%">Vero cells</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">456-462</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Dengue virus (DENV) infection is general mosquito-transmitted viral taint. It can lead to the dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Dengue is a solemn illness with no endowed antiviral medication or recognized vaccine. Therefore, we aimed to investigate the activity of &lt;em&gt;Annona squamosa&lt;/em&gt; leaf extract (ASLE) against dengue virus type-2 (DENV-2) isolated from Surabaya, Indonesia in 2013 (NCBI accession number: KT012509). &lt;strong&gt;Methods: &lt;/strong&gt;In this study, the antiviral activity of ASLE was evaluated against DENV- 2 in Vero cells using Viral ToxGlo™ Assay. In addition, we used CellTiter-Glo&lt;sup&gt;®&lt;/sup&gt; Luminescent Cell Viability Assay to set the amount of viable cells in culture based on quantitation of the ATP. &lt;strong&gt;Results: &lt;/strong&gt;DENV-2 replication inhibited by ASLE in Vero cells with IC&lt;sub&gt;50&lt;/sub&gt; = 73.78 μg/mL and SI = 4.49 when cells were treated two days after virus infection, whereas its CC&lt;sub&gt;50&lt;/sub&gt; for cytotoxicity to Vero cells was 331.54 μg/mL. Interestingly, this is the first report on the investigation of ASLE against DENV-2. &lt;strong&gt;Conclusion:&lt;/strong&gt; In summary, ASLE demonstrated the antiviral activity against DENV-2 with less toxicity, and high possibility as a drug candidate. Therefore, it might be suggested for&lt;em&gt; in vivo&lt;/em&gt; assessment in the progress of a potent antiviral against DENV-2.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">456</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Arif Nur Muhammad Ansori&lt;sup&gt;1&lt;/sup&gt;, Amaq Fadholly&lt;sup&gt;1&lt;/sup&gt;, Annise Proboningrat&lt;sup&gt;1&lt;/sup&gt;, Yulanda Antonius&lt;sup&gt;2,&lt;/sup&gt;*, Suhailah Hayaza&lt;sup&gt;3&lt;/sup&gt;, Raden Joko Kuncoroningrat Susilo&lt;sup&gt;3&lt;/sup&gt;, Bilqis Inayatillah&lt;sup&gt;4&lt;/sup&gt;, Mada Triandala Sibero&lt;sup&gt;5&lt;/sup&gt;, Sin War Naw&lt;sup&gt;6&lt;/sup&gt;, Gabrielle Ann Villar Posa&lt;sup&gt;7&lt;/sup&gt;, Teguh Hari Sucipto&lt;sup&gt;8,&lt;/sup&gt;*, Soegeng Soegijanto&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Biotechnology, University of Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Doctoral Program in Mathematics and Natural Sciences, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Master Program in Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Marine Science, Faculty of Fisheries and Marine Science, Universitas Diponegoro, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Chemistry, Myitkyina University, Myitkyina, MYANMAR.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;School of Environmental Science and Management, University of the Philippines Los Baños, Los Baños, PHILIPPINES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maslichah Mafruchati</style></author><author><style face="normal" font="default" size="100%">Jonathan Makuwira</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Number of research papers about Agricultural production, Meat, and Egg During COVID-19 Pandemic: Does it Changed than Before?</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Agricultural production</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">Egg</style></keyword><keyword><style  face="normal" font="default" size="100%">Meat</style></keyword><keyword><style  face="normal" font="default" size="100%">Research papers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">995-998</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;COVID-19 pandemic limits many physical activities of the society in public areas. The agricultural production sector is one of the important sectors in supporting the country’s nutrition demand. Research is a way to maintain the productivity of the agricultural sector. This study has a purpose to analyze if pandemic COVID-19 has an impact on the number of papers about agriculture recorded by Scopus. This study uses a quantitative with secondary data analysis approach in collecting data. The samples are paper on the Scopus website contains keywords “agriculture&amp;amp; meat”, and “agriculture&amp;amp;egg”. the period of samples are during 2019-2020. The data are analyzed using Vosviewer software to show the institution with the most related topic paper. The result shows that some papers are decreasing while others are increase based on the document type. For paper related to “agriculture” meat”, article as full type research paper increases along with review type paper. For a paper about “agriculture &amp;amp; egg”, conference type paper and review increase, while other decreases. It can be concluded that the type of paper along with the topic affects the institutions’ productivity in publishing papers&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">995</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maslichah Mafruchati&lt;sup&gt;1,&lt;/sup&gt;*, Jonathan Makuwira&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Veterinary Anatomy, Faculty of Veterinary Medicine (60115), Universitas Airlangga, Mulyorejo, C Campus, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Malawi University of Science and Technology, 5196, Limbe, MALAWI.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maria del Pilar Caramantin Soriano</style></author><author><style face="normal" font="default" size="100%">Flavia Schiappacasse</style></author><author><style face="normal" font="default" size="100%">Patricio Peñailillo</style></author><author><style face="normal" font="default" size="100%">Jaime Tapia</style></author><author><style face="normal" font="default" size="100%">Sergio Wehinger</style></author><author><style face="normal" font="default" size="100%">Camilo A Valenzuela-Vasquez</style></author><author><style face="normal" font="default" size="100%">Sarvia M Durán-Peña</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nutritional and Functional Potential of Selliera radicans Cav., a Chilean Native Halophyte</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Goodeniaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Inulin</style></keyword><keyword><style  face="normal" font="default" size="100%">Macro and Micronutrients</style></keyword><keyword><style  face="normal" font="default" size="100%">Total flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Total Phenolics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">341-346</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Selliera radicans&lt;/em&gt; was recognized as one of the foods consumed by the oldest human settlement in America (Monte Verde, Chile) that had a diet with a high component of plants.&lt;strong&gt; Objective: &lt;/strong&gt;This study aims at investigating nutritional and functional characteristics of&lt;em&gt; S. radicans&lt;/em&gt;, a native halophyte from Chile. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; An analysis of total protein, carbohydrate, ash, and moisture from &lt;em&gt;S. radicans&lt;/em&gt; leaves was performed, using standard methods. The content of macro and micronutrients was quantified by atomic absorption spectrometry. The inulin content was carried out based on the Seliwanoff reactions. &lt;em&gt;S. radicans&lt;/em&gt; leaves were extracted with methanol and the total content of phenolic and flavonoids and antioxidant activity were evaluated by spectroscopic method. &lt;strong&gt;Results:&lt;/strong&gt; Leaves from cultivated plants proved to be a suitable source of proteins (7.5 % on DW), ash (6.8 % on DW), and a wide range of macro and micronutrients, where Ca, K, and Na had the highest values. In addition, inulin (2.3% on DW), total phenolics (63.4 GAE/g LDW) and flavonoids (21.8 QE/g LDW), and antioxidant capacity (10 TE/g LDW) were noted. &lt;strong&gt;Conclusions:&lt;/strong&gt; According to the results, cultivated &lt;em&gt;S. radicans&lt;/em&gt; leaves are promising sources of food with beneficial health properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">314</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maria del Pilar Caramantin Soriano&lt;sup&gt;1,&lt;/sup&gt;*, Flavia Schiappacasse&lt;sup&gt;2&lt;/sup&gt;, Patricio Peñailillo&lt;sup&gt;3&lt;/sup&gt;, Jaime Tapia&lt;sup&gt;4&lt;/sup&gt;, Sergio Wehinger&lt;sup&gt;5&lt;/sup&gt;, Camilo A. Valenzuela-Vasquez&lt;sup&gt;2&lt;/sup&gt;, and Sarvia M. Durán-Peña&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Instituto de Química de Recursos Naturales, Universidad de Talca, Av. Lircay s/n, Talca, CHILE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Agrarias, Universidad de Talca, Talca, CHILE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Instituto de Ciencias Biológicas, Universidad de Talca, Talca, CHILE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Instituto de Química de Recursos Naturales, Universidad de Talca, Av. Lircay s/n, Talca, CHILE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias de la Salud, Departamento de Bioquímica Clínica e Inmunohematología, Universidad de Talca, Talca, CHILE.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bayyinatul Muchtaromah</style></author><author><style face="normal" font="default" size="100%">Didik Wahyudi</style></author><author><style face="normal" font="default" size="100%">Mujahidin Ahmad</style></author><author><style face="normal" font="default" size="100%">Rahmi Annisa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nanoparticle Characterization of Allium sativum, Curcuma mangga and Acorus calamus as a Basic of Nanotechnology on Jamu Subur Kandungan Madura</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Characterization</style></keyword><keyword><style  face="normal" font="default" size="100%">Garlic</style></keyword><keyword><style  face="normal" font="default" size="100%">Ionic gelation</style></keyword><keyword><style  face="normal" font="default" size="100%">Jeringau</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Temu mangga</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1152-1159</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The increasing of researcher attraction on the herbal drug after so long ignored due to difficulties in processing has opened a new door for the development of a novel of &quot;jamu Subur Kandungan&quot;. However, the constraints that then faced in consuming &quot;jamu Subur Kandungan&quot;, an herbal reproductive drug, are the solubility and poor absorption in the intestine. Therefore, this study aims to characterize nanoparticle of the combination of garlic (&lt;em&gt;Allium sativum&lt;/em&gt;), temu mangga (&lt;em&gt;Curcuma mangga&lt;/em&gt;) and jeringau (&lt;em&gt;Acorus calamus&lt;/em&gt;) encapsulated by chitosan. &lt;strong&gt;Material and Methods: &lt;/strong&gt;the simplicial of garlic (&lt;em&gt;Allium sativum&lt;/em&gt;), temu mangga (&lt;em&gt;Curcuma mangga&lt;/em&gt;) and jeringau (&lt;em&gt;Acorus calamus&lt;/em&gt;) was purchased from Materia Medica Batu Malang Indonesia. Nanoparticle of combination of garlic, temu mangga and jeringau was produced by ionic gelation method. Nanoparticle characterization was assessed by Scanning electron microscopy (SEM), Spectrophotometer Fourier Transform Infra-Red (FTIR), Particle Size analyzer (PSA) and X-ray diffraction (XRD).&lt;strong&gt; Result: &lt;/strong&gt;The ionic gelation method succeeded to make nanoparticle. The produced nanoparticle was around 438-1159 nm. The length of sonication has proven to make the particle size smaller. The particle size distribution of chitosan at the time of 90 min sonication and 150 min was classified as uneven because of the particle size clustered in the range 500-1000 nm and 3000-5000 nm. The hydroxyl (OH) group appeared at wave number 3429-2466 cm&lt;sup&gt;-1&lt;/sup&gt;, while the amide functional group appeared at wave numbers (1648-1652 cm&lt;sup&gt;-1&lt;/sup&gt;. Phosphate groups (P = O) also appeared, which is a TPP residue, at a wavenumber 1384 cm&lt;sup&gt;-1&lt;/sup&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; Chitosan-garlic nanoparticles (Allium sativum), temu mangga (&lt;em&gt;Curcuma mangga&lt;/em&gt;) and jeringau (&lt;em&gt;Acorus calamus&lt;/em&gt;) were successfully produced with ionic gelation method.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1152</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bayyinatul Muchtaromah&lt;sup&gt;1,&lt;/sup&gt;*, Didik Wahyudi&lt;sup&gt;1&lt;/sup&gt;, Mujahidin Ahmad&lt;sup&gt;1&lt;/sup&gt;, Rahmi Annisa&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Biology Department, Science and Technology Faculty, State Islamic University of Maulana Malik Ibrahim Malang, East Java, 65144, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Medical and Health Sciences, State Islamic University of Maulana Malik Ibrahim Malang, East Java, 65144, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Risya Amelia Rahmawanti</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Brenda Cristie Edina</style></author><author><style face="normal" font="default" size="100%">Lowilius Wiyono</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nanoparticle Synthesis and Cytotoxicity of Kaempferia pandurata Roxb. Extract to the Growth of MDA-MB-231 Breast Cancer Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaempferia pandurata Roxb.</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA-MB-231 cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Temu Kunci</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">109-114</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Breast cancer is the most common cancer worldwide and in Indonesia. &lt;em&gt;Kaempferia pandurata &lt;/em&gt;Roxb. is a herbal plant from South-East Asia which is known for its ability to inhibit the growth of Estrogen Receptor (ER) + breast cancer cell line from the former study. However, its effect on ER- breast cancer cell lines had not been studied. Therefore, we want to examine the cytotoxicity effect of &lt;em&gt;K. pandurata &lt;/em&gt;Roxb. on ER- breast cancer cell line (MDA-MB-231). Nanoparticle is a form of preparation that optimizes the activity of any compound to the targeted cell. Therefore, it is expected that it can increase the effectivity of anticancer in &lt;em&gt;Kaempferia pandurata&lt;/em&gt; Roxb. In this study, the rhizome of &lt;em&gt;K. pandurata &lt;/em&gt;Roxb. trituration was dried and extracted with n-hexane solvent. Nanoparticle of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. was synthesized with CaCl&lt;sub&gt;2&lt;/sub&gt;, chitosan, and alginate by stirring with a magnetic stirrer, adjusting pH, and centrifugation. Then, nanoparticle was analized by UV/VIS spectrofotometry and transmission electron microscopy (TEM). The cytotoxicity of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. extract and nanoparticle were examined with MTT assay. The result of this test is data of inhibition percentage and IC&lt;sub&gt;50&lt;/sub&gt; value. The result showed that n-hexane extract of &lt;em&gt;K. pandurata &lt;/em&gt;Roxb. is synthesized into nanoparticle form with 99,43% yield percentage (entrapment value). Anticancer activity of n-hexane extract and nanoparticle of&lt;em&gt; K. pandurata&lt;/em&gt; Roxb. is moderate with IC&lt;sub&gt;50&lt;/sub&gt; value of the extract is 87,23 μg/ml and the nanoparticle is 24,23 μg/ml. The nanoparticle’s activity is better than the extract. n-Hexane extract and nanoparticle of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. has cytotoxicity effects towards MDA-MB-231 cell line. Nanoparticle can increase the cytotoxicity effect of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. extract because its hydrophobic feature and nanometer size.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">109</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Risya Amelia Rahmawanti&lt;sup&gt;1&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;2,3,&lt;/sup&gt;*, Brenda Cristie Edina&lt;sup&gt;1&lt;/sup&gt;, Lowilius Wiyono&lt;sup&gt;1&lt;/sup&gt;, Rafika Indah Paramita&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Undergraduate Medical Student, Faculty of Medicine University of Indonesia, Jalan Salemba Raya No.6, Jakarta Pusat, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine University of Indonesia, Jalan Salemba Raya No.6, Jakarta Pusat, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Center – IMERI, Faculty of Medicine University of Indonesia, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amr A Fouad</style></author><author><style face="normal" font="default" size="100%">Entesar F Amin</style></author><author><style face="normal" font="default" size="100%">Amira F Ahmed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Naringenin and Vanillin Mitigate Cadmium-Induced Pancreatic Injury in Rats via Inhibition of JNK and p38 MAPK Pathways</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CdCl2</style></keyword><keyword><style  face="normal" font="default" size="100%">JNK/MAPK</style></keyword><keyword><style  face="normal" font="default" size="100%">Naringenin</style></keyword><keyword><style  face="normal" font="default" size="100%">p38/MAPK</style></keyword><keyword><style  face="normal" font="default" size="100%">Pancreas</style></keyword><keyword><style  face="normal" font="default" size="100%">Vanillin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">742-748</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cadmium can induce pancreatic injury via oxidative stress, inflammation and apoptosis. Naringenin (NGN) and vanillin (VLN) exert antioxidant, anti-inflammatory, and antiapoptotic effects. &lt;strong&gt;Objective: &lt;/strong&gt;The likely ameliorative effects of NGN, VLN and their combination were studied in rats exposed to cadmium-induced pancreatic injury. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Rats received NGN (50 mg/kg/day, p.o.), VLN (100 mg/ kg/day, p.o.), or NGN + VLN for 7 days and one injection of CdCl&lt;sub&gt;2&lt;/sub&gt; (2 mg/kg, i.p.) on the 6&lt;sup&gt;th&lt;/sup&gt; day. &lt;strong&gt;Results:&lt;/strong&gt; Cadmium significantly lowered serum amylase and insulin levels. Cadmium also caused significant increments of malondialdehyde, tumor necrosis factor-α, interleukin-1β, nuclear factor-κB p65, Bax/Bcl-2 ratio and phosphorylated c-Jun N-terminal kinase (p-JNK) and p38 mitogen-activated protein kinases (MAPKs) and significant decrements of reduced glutathione and catalase in the pancreas of rats received CdCl&lt;sub&gt;2&lt;/sub&gt;. Additionally, CdCl&lt;sub&gt;2&lt;/sub&gt; caused marked histopathological necrosis and significantly increased caspase-3 expression in pancreatic tissue. The cadmium-induced biochemical, histopathological and immunohistochemical changes were significantly ameliorated by NGN, VLN and NGN + VLN. However, NGN + VLN caused more significant ameliorative effects than did NGN and VLN alone. &lt;strong&gt;Conclusion: &lt;/strong&gt;NGN, VLN and NGN + VLN afforded significant protection of pancreas in rats exposed to cadmium insult through modulation of JNK and p38 MAPK pathways and inhibition of oxidative stress, inflammation and apoptosis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">742</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amr A Fouad&lt;sup&gt;1,2,&lt;/sup&gt;*, Entesar F Amin&lt;sup&gt;2&lt;/sup&gt;, Amira F Ahmed&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Al-Baha University, Al-Baha, SAUDI ARABIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Histology, Faculty of Medicine, Minia University, El-Minia, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Ema Dewanti</style></author><author><style face="normal" font="default" size="100%">Inka Nurul Fadliani</style></author><author><style face="normal" font="default" size="100%">Nessa Aqilla</style></author><author><style face="normal" font="default" size="100%">Salwaa Salsabila</style></author><author><style face="normal" font="default" size="100%">Vera Ladeska</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Nephroprotective And Antioxidant Activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Gentamicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterculia rubiginosa Zoll Ex. Miq.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">843-849</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Sterculia&lt;/em&gt; has an antioxidant activity. The &lt;em&gt;Sterculia &lt;/em&gt;genus has phenols and flavonoids content, and this chemical content may be have an nephroprotective activity. &lt;strong&gt;Objective: &lt;/strong&gt;The study was to investigate the &lt;em&gt;in vitro &lt;/em&gt;study of antioxidant activity with DPPH and FRAP study and nephroprotective activity of &lt;em&gt;Sterculia rubiginosa &lt;/em&gt;Zoll. Ex Miq. Leaves extract. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The leaves was extracted using ethanol. This extract was determined for antioxidant activity by &lt;em&gt;in vitro &lt;/em&gt;study with DPPH and FRAP methods, determined the content of total phenols, total flavonoids, and also identification of chemical content. Nephrotoxicity study done by induced gentamycin. The groups divided 6 group, consist: negative control, positive control, normal control, and the extract with dose 50 mg/kg, 100 mg/kg, and 200 mg/ kg. The parameter for nephroprotective activity was tubular necrosis, the presence of tubules casts and glomerular damage, creatinine serum, and urea. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol extract has IC&lt;sub&gt;50 &lt;/sub&gt;162.34 μg/ml for DPPH scavenging activity and 18.65 ± 3.53 FeEAC (Mol/g) for FRAP. The secondary metabolite presence flavonoids, tannins, terpenes, alkaloids, and glycosides. The total phenols 462.36 ± 9.23 mg GAE/gr, total flavonoids content 59.44 ± 0.11 mg QE/gr extract. All the dose have an nephroprotective activity, but the best dose was 50 mg/kg. &lt;strong&gt;Conclusion: &lt;/strong&gt;The ethanol extract of &lt;em&gt;Sterculia rubiginosa&lt;/em&gt; showed antioxidant activity and nephroprotective activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">843</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rini Prastiwi&lt;sup&gt;1,&lt;/sup&gt;*, Ema Dewanti&lt;sup&gt;1&lt;/sup&gt;, Inka Nurul Fadliani&lt;sup&gt;2&lt;/sup&gt;, Nessa Aqilla&lt;sup&gt;2&lt;/sup&gt;, Salwaa Salsabila&lt;sup&gt;2&lt;/sup&gt;, Vera Ladeska&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Muhammadiyah prof. Dr. HAMKA, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy Universitas Muhammadiyah prof. Dr. HAMKA, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jai Prabhu</style></author><author><style face="normal" font="default" size="100%">K Prabhu</style></author><author><style face="normal" font="default" size="100%">Anathbandhu Chaudhuri</style></author><author><style face="normal" font="default" size="100%">Mudiganti Ram Krishna Rao</style></author><author><style face="normal" font="default" size="100%">VS Kalai Selvi</style></author><author><style face="normal" font="default" size="100%">TK Balaji</style></author><author><style face="normal" font="default" size="100%">Sruthi Dinakar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuro-protective Effect of Ayurveda Formulation, Saraswatharishtam, on Scopolamine Induced Memory Impairment in Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ayurvedic medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Elevated Plus Maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Piracetam</style></keyword><keyword><style  face="normal" font="default" size="100%">Saraswatharishtam</style></keyword><keyword><style  face="normal" font="default" size="100%">Scopolamine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">6-13</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;In the management of neurodegenerative and neuropsychiatric diseases, memory loss remains very challenging. Saraswatharishtam (SWRT) is an ayurvedic formulation prescribed for several neurological illnesses like acute anxiety, partial memory loss, slurred speech, neuro degenerative diseases like Parkinson’s, Alzheimer’s etc. &lt;strong&gt;Methods:&lt;/strong&gt; Present study explores the possibilities of curative effects of SWRT on Scopolamine induced memory impairment and to compare the effects of commonly used drug piracetam. Adult Wistar Swiss albino mice were used for this experiment and divided into five different groups for the treatments of the drugs in various combinations. The first group was vehicle treated control while the second group was treated with scopolamine to induce memory impairment. The third group of animals were treated with Scopolamine where the mice were pretreated with standard neuroprotective drug Piracetam, while the fourth and fifth group of animals were treated with scopolamine and the animals were pretreated with SWRT at the doses of 200 and 400 mg/kg respectively to compare with the effect of Piracetam. Scopolamine was administered on day eight, only for 45 minutes in all the cases (Group I- Group V). Several neurobehavioral parameters were examined to confirm the neuroprotective effects of SWRT. &lt;strong&gt;Results: &lt;/strong&gt;Saraswatharishtam significantly reversed the memory loss in mice model revealed from elevated plus maze, radial maze and rectangular maze experiments justifying its neuroprotective potential as observed in usually used synthetic Piracetam. SWRT was found to be nontoxic and very promising antioxidant recorded from acute and chronic toxicological studies. &lt;strong&gt;Conclusions: &lt;/strong&gt;It is suggested that SWRT, could be used as safe and easily available Ayurveda medicine to treat neurological dysfunctions without any side effects. Further translational research is needed to explore its neuro-protective potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">6</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jai Prabhu&lt;sup&gt;1&lt;/sup&gt;, K Prabhu&lt;sup&gt;2&lt;/sup&gt;, Anathbandhu Chaudhuri&lt;sup&gt;3&lt;/sup&gt;, Mudiganti Ram Krishna Rao&lt;sup&gt;4,&lt;/sup&gt;*, VS Kalai Selvi&lt;sup&gt;5&lt;/sup&gt;, TK Balaji&lt;sup&gt;6&lt;/sup&gt;, Sruthi Dinakar&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;strong&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Sree Balaji Medical College and Hospital, Chennai, Tamil nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department of Anatomy, Sree Balaji Medical College and Hospital, Chennai, Tamil nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama, 35401, USA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai, Tamil nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Biochemistry, Sree Balaji Medical College and Hospital, Chennai, Tamil nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Anatomy, Chettinad Health City, Chennai 603103, Tamil nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Ayurvedic Physician, Kottakkal Arya Vaidhya Sala, Chennai, Tamil nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jai Prabhu</style></author><author><style face="normal" font="default" size="100%">K Prabhu</style></author><author><style face="normal" font="default" size="100%">Anathbandhu Chaudhuri</style></author><author><style face="normal" font="default" size="100%">Mudiganti Ram Krishna Rao</style></author><author><style face="normal" font="default" size="100%">V S Kalai Selvi</style></author><author><style face="normal" font="default" size="100%">T K Balaji</style></author><author><style face="normal" font="default" size="100%">Shruthi Dinakar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuro-protective Effect of Ayurveda Formulation, Saraswatharishtam, on Scopolamine Induced Memory Impairment in Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ayurvedic</style></keyword><keyword><style  face="normal" font="default" size="100%">Elevated Plus Maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuro-protection</style></keyword><keyword><style  face="normal" font="default" size="100%">Piracetam</style></keyword><keyword><style  face="normal" font="default" size="100%">Saraswatharishtam</style></keyword><keyword><style  face="normal" font="default" size="100%">Scopolamine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">465-472</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; In the management of neurodegenerative and neuropsychiatric diseases, memory loss remains very challenging. Saraswatharishtam (SWRT) is an ayurvedic formulation prescribed for several neurological ailments like acute anxiety, partial memory loss, slurred speech, neuro-degenerative diseases like Parkinson’s, Alzheimer’s etc. &lt;strong&gt;Methods:&lt;/strong&gt; Present study explores the possibilities of curative effects of SWRT on Scopolamine induced memory impairment and to compare the effects of commonly used drug Piracetam. Adult Wistar Swiss albino mice were used for this experiment and divided into five different groups for the treatments of the drugs in various combinations. The first group was vehicle treated control while the second group was treated with scopolamine to induce memory impairment. The third groups of animals were treated with Scopolamine where the mice were pretreated with standard neuro-protective drug Piracetam, while the fourth and fifth groups of animals were treated with scopolamine and the animals were pretreated with SWRT at the doses of 200 and 400 mg/kg respectively to compare with the effect of Piracetam. Scopolamine was administered on day eight, only for 45 minutes in all the cases (Group I- Group V). Several neurobehavioral parameters were examined to confirm the neuro-protective effects of SWRT. &lt;strong&gt;Results:&lt;/strong&gt; Saraswatharishtam significantly reversed the memory loss in mice model as revealed from elevated plus maze, radial maze and rectangular maze experiments justifying its neuroprotective potential as observed in usually used synthetic Piracetam. SWRT was found to be nontoxic and very promising antioxidant recorded from acute and chronic toxicological studies. &lt;strong&gt;Conclusions: &lt;/strong&gt;It is suggested that SWRT, could be used as safe and easily available Ayurveda medicine to treat neurological dysfunctions without any side effects. Further translational research is needed to explore its neuro-protective potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">465</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jai Prabhu&lt;sup&gt;1&lt;/sup&gt;, K Prabhu&lt;sup&gt;2&lt;/sup&gt;, Anathbandhu Chaudhuri&lt;sup&gt;3&lt;/sup&gt;, Mudiganti Ram Krishna Rao&lt;sup&gt;4,*&lt;/sup&gt;, VS Kalai Selvi&lt;sup&gt;5&lt;/sup&gt;, TK Balaji&lt;sup&gt;6&lt;/sup&gt;, Sruthi Dinakar&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Sree Balaji Medical College and Hospital, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department of Anatomy, Sree Balaji Medical College and Hospital, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama, 35401, USA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Biochemistry, Sree Balaji Medical College and Hospital, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Anatomy, Chettinad Health City, Chennai 603103, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Ayurvedic Physician, Kottakkal Arya Vaidhya Sala, Chennai, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Didin Wahyu Agustina</style></author><author><style face="normal" font="default" size="100%">Mulya Dwi Wahyuningsih</style></author><author><style face="normal" font="default" size="100%">Sri Widyarti</style></author><author><style face="normal" font="default" size="100%">Aris Soewondo</style></author><author><style face="normal" font="default" size="100%">Hideo Tsuboi</style></author><author><style face="normal" font="default" size="100%">Muhaimin Rifa’i</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Noni Juice (Morinda citrifolia) to Prevent Cancer Progression in Mice Induced DMBA and Cigarette Smoke Exposure</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Homeostatic</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunotoxin</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Noni juice</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor progression</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">946-951</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Accumulation of polycyclic aromatic hydrocarbons (PAH) in the body commonly lead to degenerative disease such as cancer. This study aims to investigate the potential of &lt;em&gt;Morinda citrifolia&lt;/em&gt; to maintain the immune system against toxic exposure. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;This study used Five weeks old male Balb/C mice as animal model. The 7,12-Dimethylbenz(a)anthracene (DMBA) was administrated for six weeks following with 3 days cigarette smoke (CS) exposure then treated with noni juice (&lt;em&gt;M. citrifolia&lt;/em&gt;) for two weeks. Experimental animals were divided into six groups. Normal control (N); DMBA+CS; Cisplatin; D1; D2; and D3. Profil of CD4&lt;sup&gt;+&lt;/sup&gt;TNFα&lt;sup&gt;+&lt;/sup&gt;, CD11b+IL6&lt;sup&gt;+&lt;/sup&gt;, CD11b&lt;sup&gt;+&lt;/sup&gt;IFNγ&lt;sup&gt;+&lt;/sup&gt;, CD4&lt;sup&gt;+&lt;/sup&gt;CD25&lt;sup&gt;+&lt;/sup&gt; IL10&lt;sup&gt;+&lt;/sup&gt;, NK&lt;sup&gt;+&lt;/sup&gt;IL6&lt;sup&gt;+&lt;/sup&gt; cells was analyzed by flow cytometry and data was analyzed with one-way ANOVA and Post Hoc Tukey HSD test with a significance of p-values &amp;lt; 0.05. &lt;strong&gt;Results:&lt;/strong&gt; This study show that DMBA+CS induction increasing level of CD11b&lt;sup&gt;+&lt;/sup&gt;IL6&lt;sup&gt;+&lt;/sup&gt;, CD4&lt;sup&gt;+&lt;/sup&gt;CD25&lt;sup&gt;+&lt;/sup&gt; IL-10&lt;sup&gt;+&lt;/sup&gt; and NK&lt;sup&gt;+&lt;/sup&gt; IL-6&lt;sup&gt;+&lt;/sup&gt; meanwhile decreasing CD4&lt;sup&gt;+&lt;/sup&gt;TNFα&lt;sup&gt;+&lt;/sup&gt;significantly (P&amp;lt;0.5) than Normal group. Noni juice in dose 90 mg/Kg BW decrease cytokine pro-inflammation (IL-6 and IFNγ) both in macrophage and NK cell profile significantly (P&amp;lt;0.05). Noni juice in 30 mg/Kg BW could improve the activation CD4&lt;sup&gt;+&lt;/sup&gt;TNFα&lt;sup&gt;+&lt;/sup&gt; significantly (P&amp;lt;0.05). Noni juice also has efficacy to control T regulator activation to prevent tumor escape. &lt;strong&gt;Conclusion: &lt;/strong&gt;These results suggest that noni juice has anti-cancer potencies by maintain homeostasis of immune system and could be immune herbal supplement.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">946</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Didin Wahyu Agustina&lt;sup&gt;1&lt;/sup&gt;, Mulya Dwi Wahyuningsih&lt;sup&gt;1&lt;/sup&gt;, Sri Widyarti&lt;sup&gt;1&lt;/sup&gt;, Aris Soewondo&lt;sup&gt;1&lt;/sup&gt;, Hideo Tsuboi&lt;sup&gt;3&lt;/sup&gt;, Muhaimin Rifa’i&lt;sup&gt;1,2&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Biology Department, Faculty of Mathematics and Natural sciences, Brawijaya University. Malang 65145, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Biosystems Research Center, LPPM University of Brawijaya, Malang 65145, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yuliana Salosso</style></author><author><style face="normal" font="default" size="100%">Siti Aisiah</style></author><author><style face="normal" font="default" size="100%">Lumban Nauli Lumban Toruan</style></author><author><style face="normal" font="default" size="100%">Wesly Pasaribu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nutrient Content, Active Compound and Antibacterial Activity of Padina australis against Aeromonas hydropilla</style></title><secondary-title><style face="normal" font="default" size="100%">Active compound, Antibacterial activity, Padina australis, Nutrient content,</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Active compound</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Nutrient content</style></keyword><keyword><style  face="normal" font="default" size="100%">Padina australis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">771-776</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Padina australis &lt;/em&gt;is one of the brown macroalgae that possess several compounds that can be used for various medicinal properties. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to analyze the nutrient content, active compounds, and antibacterial activity of &lt;em&gt;Padina australis&lt;/em&gt; against &lt;em&gt;Aeromonas hydropilla.&lt;/em&gt; &lt;strong&gt;Methods:&lt;/strong&gt; The nutrient content and phytochemical composition of&lt;em&gt; P. australis&lt;/em&gt; were examined in this study. The antibacterial effect was evaluated using the disc method against &lt;em&gt;A. hydropilla.&lt;/em&gt; &lt;strong&gt;Results:&lt;/strong&gt; The nutrient content of &lt;em&gt;P. australis&lt;/em&gt; include 38.5% carbohydrate, 2.07% fat, 13.89% protein, 16.12% water, 33.34% ash, 8.54% total amino acid, and minerals (11.36% calcium, 0.22% iron, and 1.81% potassium). Phytochemical analysis showed that &lt;em&gt;P. australis &lt;/em&gt;contained phenols, tannin, flavonoid, and steroid. These compound may be responsible for inhibiting &lt;em&gt;A. hydropilla,&lt;/em&gt; with an inhibition zone of 10.5 mm for water extract of &lt;em&gt;P. australis &lt;/em&gt;and 10 mm for methanol extract &lt;em&gt;P. australis.&lt;/em&gt; &lt;strong&gt;Conclusion: &lt;/strong&gt;This study revealed that &lt;em&gt;P. australis&lt;/em&gt; produced antibacterial effect against &lt;em&gt;A. hydropilla&lt;/em&gt; which could be potential for further antimicrobial agent development.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">771</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yuliana Salosso&lt;sup&gt;1,&lt;/sup&gt;*, Siti Aisiah&lt;sup&gt;2&lt;/sup&gt;, Lumban Nauli Lumban Toruan&lt;sup&gt;3&lt;/sup&gt;, Wesly Pasaribu&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Study Program of Aquaculture, Faculty of Fisheries and Marine Science, Nusa Cendana University, Kupang 85228, East Nusa Tenggara, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Aquaculture, Lambung Mangkurat University, Banjarbaru 70711, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Study Program of Aquatic Resource Management, Faculty of Fisheries and Marine Science, Nusa Cendana University, Kupang 85228, East Nusa Tenggara, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">Linder Figueroa-Salvador</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effect of Sacha Inchi Oil (Plukenetia volubilis L.) in an Experimental Model of Epilepsy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Convulsion</style></keyword><keyword><style  face="normal" font="default" size="100%">Epilepsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Omega</style></keyword><keyword><style  face="normal" font="default" size="100%">Pentylenetetrazole</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha inchi</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1591-1596</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Experimental studies have demonstrated that fatty acids such as omega 3 and 6 have anti-inflammatory, anticonvulsant, cardio protective and anti-tumor effects. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to determine the protective effect of sacha inchi oil on pentylenetetrazoleinduced seizures in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Thirty male Balb/C albino mice of 8 weeks of age were purchased from the National Institute of Health (Lima-Peru). The animals were divided into 5 groups of 6 animals each one. Group I: Control; PTZ (pentylenetetrazole 80 mg / kg, s.c.). II: PTZ + Diazepam (1 mg / kg; s.c.). Group III, IV, V: PTZ + sacha inchi oil at single doses of 250, 500, 1000 mg / kg respectively orally. Sacha inchi oil was administered 30 minutes before induction of seizures by PTZ. Next, various parameters such as latency, seizure frequency, duration and score were scored according to Racine scale. The program Graph Pad Prism v.4 was used for statistical analysis. &lt;strong&gt;Results: &lt;/strong&gt;As result, the experimental group treated with sacha inchi oil at maximum dose of 1000 mg/kg showed better results in response to PTZ induced seizure; low levels of seizures, frequency and duration (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.001; ANOVA, &lt;em&gt;P&lt;/em&gt; &amp;lt;0.001 Post-hoc Dunnett test). &lt;strong&gt;Conclusion: &lt;/strong&gt;It is concluded that Sacha inchi oil presented anticonvulsant effect at the highest doses tested being very similar to Diazepam. The main mechanism could be by reducing free radical and improving GABA levels in the brain.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;3&lt;/sup&gt;, César Franco- Quino&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz- Cerrate&lt;sup&gt;5&lt;/sup&gt;, Linder Figueroa- Salvador&lt;sup&gt;6 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica Del Sur, Lima, PERU. 6School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Medicine, Universidad Peruana de&amp;nbsp;Ciencias Aplicadas, Lima PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ismael Leon-Rivera</style></author><author><style face="normal" font="default" size="100%">Juana Villeda-Hernandez</style></author><author><style face="normal" font="default" size="100%">Elizur Montiel-Arcos</style></author><author><style face="normal" font="default" size="100%">Isaac Tello</style></author><author><style face="normal" font="default" size="100%">Maria Yolanda Rios</style></author><author><style face="normal" font="default" size="100%">Samuel Estrada-Soto</style></author><author><style face="normal" font="default" size="100%">Angelica Berenice Aguilar</style></author><author><style face="normal" font="default" size="100%">Veronica Nunez-Urquiza</style></author><author><style face="normal" font="default" size="100%">Jazmin Mendez-Miron</style></author><author><style face="normal" font="default" size="100%">Victoria Campos-Pena</style></author><author><style face="normal" font="default" size="100%">Sergio Hidalgo-Figueroa</style></author><author><style face="normal" font="default" size="100%">Eva Hernandez</style></author><author><style face="normal" font="default" size="100%">Gerardo Hurtado</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effects of Ganoderma curtisii Polysaccharides After Kainic Acid-Seizure Induced</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticonvulsant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma curtisii</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">β-glucan</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1046-1054</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Epilepsy is one of the major neurological disorders affecting world population. Although, some &lt;em&gt;Ganoderma&lt;/em&gt; species have shown neuroprotective activities, the effects of polysaccharides isolated from &lt;em&gt;Ganoderma curtisii&lt;/em&gt; on epileptic seizures have not been reported. &lt;strong&gt;Objective:&lt;/strong&gt; The aims of the present study were to determine whether treatment with a polysaccharide fraction (GCPS-2) from a Mexican &lt;em&gt;Ganoderma curtisii &lt;/em&gt;strain can reduce seizures, and the increases in the levels of apoptotic molecules and inflammatory cytokines in kainic acid-induced seizure mouse model. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Rats were separated in groups: Control group received 2.5% Tween 20 solution; GCPS-2 groups were administered GCPS-2 (10, 40, or 80 mg/kg); KA group received KA 10 mg/kg; GCPS-2+KA received GCPS- 2 and 30 min later KA. Pathological changes in neuronal morphology, expression of B-cell lymphoma-2, and pro-inflammatory cytokines (interleukin1-β and tumor necrosis factor-α) in the rat hippocampus and cortex were determined by immunohistochemistry.&lt;strong&gt; Results: &lt;/strong&gt;&lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides (GCPS-2) inhibited convulsions in rats. Moreover, treatment with GCPS-2 reduced the increased levels of apoptotic signaling molecules (Bcl-2) and proinflammatory mediators (in the kainic acid-treated hippocampus and cortex). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides have a neuroprotective potential against epilepsy, partially through its ability to inhibit neurotoxic events in the &lt;em&gt;in vivo&lt;/em&gt; hippocampus and cortex.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1046</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ismael León-Rivera&lt;sup&gt;1&lt;/sup&gt;*, Juana Villeda-Hernández&lt;sup&gt;2&lt;/sup&gt;, Elizur Montiel-Arcos&lt;sup&gt;3&lt;/sup&gt;, Isaac Tello&lt;sup&gt;3&lt;/sup&gt;, María Yolanda Rios&lt;sup&gt;1&lt;/sup&gt;, Samuel Estrada-Soto&lt;sup&gt;4&lt;/sup&gt;, Angélica Berenice Aguilar&lt;sup&gt;1&lt;/sup&gt;, Verónica Núñez-Urquiza&lt;sup&gt;1&lt;/sup&gt;, Jazmín Méndez-Mirón&lt;sup&gt;5&lt;/sup&gt;, Victoria Campos-Peña&lt;sup&gt;2&lt;/sup&gt;, Sergio Hidalgo-Figueroa&lt;sup&gt;6&lt;/sup&gt;, Eva Hernández&lt;sup&gt;7&lt;/sup&gt;, Gerardo Hurtado&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Avenida Insurgentes Sur No. 3877 Col. La Fama Tlalpan, Ciudad de México, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;CONACYT-IPICYT Consorcio de Investigación, Innovación y Desarrollo para las Zonas Áridas, 78216 San Luis Potosí, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Instituto Nacional de Salud Pública. Avenida Universidad 565, Col. Santa María Ahuacatitla Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nguyen Van Long</style></author><author><style face="normal" font="default" size="100%">Chu Van Men</style></author><author><style face="normal" font="default" size="100%">Anh Vu Tuan</style></author><author><style face="normal" font="default" size="100%">Nguyen Van Manh</style></author><author><style face="normal" font="default" size="100%">Thanh Chu Duc</style></author><author><style face="normal" font="default" size="100%">Ha Bui Thi Thu</style></author><author><style face="normal" font="default" size="100%">Hoang Van Luong</style></author><author><style face="normal" font="default" size="100%">Le Bach Quang</style></author><author><style face="normal" font="default" size="100%">Pham Gia Khanh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A New LC/MS/MS Method for the Analysis of Phyllanthin in Rat Plasma and its Application on Comparative Bioavailability of Phyllanthin in Different Formulations after Oral Administration in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">LC-MS/MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacokinetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Phospholipid</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthin</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasma</style></keyword><keyword><style  face="normal" font="default" size="100%">Quantitation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">968-975</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;A simple, short UPLC/MS/MS method for quantitation of phyllanthin in rat plasma in less than 2 minutes have been developed and fully validated. The validated method was used to investigate the pharmacokinetic properties of phyllanthin in PA extract and phospholipid complex of PA extract in rat. &lt;strong&gt;Methods:&lt;/strong&gt; The separation was carried out on Acquity C&lt;sub&gt;18 &lt;/sub&gt;(50 x 2.1 mm; 1.7 μm), with a mobile phase of 10 mM aqueous amonium acetate and acetonitrile (10:90; v/v), at a flow rate of 0.2 mL/min. Felodipin was used as internal standard. Phyllanthin is extracted from a small volume of rat plasma (100 μl) by means of liquid-liquid extraction method with tert butyl methyl ether. Electrospray ionization (ESI) mass spectrometry was applied in positive mode at capillary voltage of 4000 V for both phyllanthin and IS, cone voltage of 24 V for phyllanthin and 20 V for IS, desolvation temperature of 360oC, cone gas flow of 25 L/h, collision energy of 12 V for phyllanthin and 10 V for IS. Multiple reaction monitoring (MRM) was used to monitor the transitions at m/z (Q1/Q3) 436.41/355.36 for phyllanthin and 384.20/352.18 for IS. &lt;strong&gt;Results:&lt;/strong&gt; The linear calibration curve of phyllanthin was obtained over the concentration range of 0.5 – 100 ng/mL. The intra‐ and inter‐day precisions were less than 7.08 % and the accuracies were within ± 7.55%. The Cmax values of phyllanthin from two different preparations in rat plasma after oral administration of 2.0 mg/kg were 11.44 and 31.44 ng/ml, and the AUC values were 18.07 and 41.43 h.ng/ml, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; A simple, short UPLC/MS/MS method for quantitation of phyllanthin in rat plasma in less than 2 minutes have been developed and fully validated. The bioavailability of phyllanthin from the phospholipid complex of PA extract in rat plasma was significantly improved compared with that of raw PA extract after oral administration.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">968</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nguyen Van Long&lt;sup&gt;#&lt;/sup&gt;, Chu Van Men&lt;sup&gt;#,&lt;/sup&gt;*, Anh Vu Tuan, Nguyen Van Manh, Thanh Chu Duc, Ha Bui Thi Thu, Hoang Van Luong, Le Bach Quang, Pham Gia Khanh&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;nstitute of Biomedicine and Pharmacy, Vietnam Military Medical University, 222-Phung Hung Street, Ha Dong District, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;#&lt;/sup&gt;These authors contributed equally to this work&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nina Handayani</style></author><author><style face="normal" font="default" size="100%">Hidayat Sujuti</style></author><author><style face="normal" font="default" size="100%">Nur Permatasari</style></author><author><style face="normal" font="default" size="100%">Achmad Rudijanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Niacin Regulates Glucose Reactive Protein (GRP78), Protein Carbonyl Content (PCC) and Malondialdehyde (MDA) in the Hyperglycemic Human Lens Epithelial Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetic cataract</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">GRP78</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">Niacin</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">PCC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">8-11</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Niacin is part of the chemical structure of coenzymes nicotinamide adenine nucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Previous studies suggested that a high niacin intake could decrease the prevalence of cataracts, which may delay the onset of diabetic cataract. &lt;strong&gt;Aim:&lt;/strong&gt; The aim of this study was to evaluate the effect of niacin on the hyperglycemia-induced osmotic stress and oxidative stress in human lens epithelial cells. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Human lens epithelial cells were cultured in a high glucose condition. Oxidative stress markers, including malondialdehyde (MDA), protein carbonyl content (PCC) and glucose reactive protein (GRP), were measured using TBARS analysis (MDA) and ELISA (PCC and GRP) after 72 h incubation.&lt;strong&gt; Results:&lt;/strong&gt; The MDA levels increased after high glucose administration relative to that in the control group (p &amp;lt;0.05). Further, the groups that were co-treated with niacin showed decrease in the MDA levels for all doses of niacin and the lowest mean MDA level was obtained with 100 μM niacin. There was a decrease in the PCC levels for all doses, whereas the lowest mean PCC level was observed at a 100 μM niacin dose. The GRP levels increased after high glucose administration as compared with the control group. Also, the groups that were co-treated with niacin exhibited statistically significant reduction.&lt;strong&gt; Conclusion:&lt;/strong&gt; These results suggest that niacin can inhibit the osmotic stress and oxidative stress which may lead to the progression of a diabetic cataract. Also, it may maintain lens transparency by acting as a precursor for glutathione biosynthesis and an antioxidant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">8</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nina Handayani&lt;sup&gt;1,2,*&lt;/sup&gt;, Hidayat Sujuti&lt;sup&gt;3&lt;/sup&gt;, Nur Permatasari&lt;sup&gt;4&lt;/sup&gt;, Achmad Rudijanto&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Brawijaya University, Malang, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Ophthalmology, Faculty of Medicine, Brawijaya University, Saiful Anwar Hospital, Malang, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Brawijaya University, Malang, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Brawijaya University, Malang, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Endocrinology and Metabolic Disease, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Saiful Anwar Hospital Malang, Malang, East Java,INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pulak Majumder</style></author><author><style face="normal" font="default" size="100%">M Paridhavi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Novel Poly‐herbal Formulation Hastens Diabetic Wound Healing with Potent Antioxidant Potential: A Comprehensive Pharmacological Investigation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Poly herbal formulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound model</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">324-331</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Objective&lt;/strong&gt;: Currant investigation was aimed to evaluate the wound healing and antioxidant potentials of the novel Poly-herbal Formulation (PHF) in diabetic rat’s models and &lt;em&gt;in-vitro&lt;/em&gt; antioxidant assays respectively. &lt;strong&gt;Methods&lt;/strong&gt;: The wound models viz., excision, incision and dead space by using wistar strain albino rats were adopted for this investigation. The free radical scavenging assays were employed for investigation of Antioxidant potential in poly herbal formulation. The constraints studied for assessment of wound repair were percentage closing percentage of wound, tensile strength of repaired tissue, breaking strength of granulation tissue and valuation of hydroxyproline content on dried tissue. The histopathological sections of granulation tissues obtained in dead space wound model were studied for the distribution of collagen and other histopathological changes. Four groups were used in this study with six animals each. Group I and Group II acts as normal control and diabetic control whereas Group III and Group IV was used as glibenclamide treated (1mg/kg b.w.) and PHF (500 mg/kg b.w.) treated group respectively. On the other hand the various antioxidant assays like DPPH, scavenging assays, hydrogen peroxide assay etc. were investigated. &lt;strong&gt;Results:&lt;/strong&gt; The PHF has been significantly healing the wounds in diabetic rats within 18 days, while diabetic control rats healed the wound about 86.12% in the same conditions and time. The wound breaking strength and histopathological studies of healed skin was signified the results. Significant (p&amp;lt;0.01) increase in wound breaking strength as well as epithelialization and the level of hydroxyproline was observed in PHF treated animals comparison with diabetic control group. PHF has also shown significant antioxidant potential in &lt;em&gt;in-vitro&lt;/em&gt; assays. &lt;strong&gt;Conclusion&lt;/strong&gt;: All these investigation indicates the significant wound healing and antioxidant potential of PHF in the experimental animal groups in diabetic condition.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">324</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Pulak Majumder&lt;sup&gt;1,&lt;/sup&gt;*, M Paridhavi&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Research scholar, PRIST University, Thanjavour, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Professor and Principal, Rajiv Gandhi Institute of Pharmacy, Trikaripur, Kerala, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Heba Abdel-Hady</style></author><author><style face="normal" font="default" size="100%">Mortada Mohamed El-Sayed</style></author><author><style face="normal" font="default" size="100%">Afaf Ahmed Abdel-Hady</style></author><author><style face="normal" font="default" size="100%">Maher Mahmoud Hashash</style></author><author><style face="normal" font="default" size="100%">Ahmed Mohamed Abdel-Hady</style></author><author><style face="normal" font="default" size="100%">Tarek Aboushousha</style></author><author><style face="normal" font="default" size="100%">El-Sayed Saleh Abdel-Hameed</style></author><author><style face="normal" font="default" size="100%">Ezzat El-Sayed Abdel- Lateef</style></author><author><style face="normal" font="default" size="100%">Eman Abdalla Morsi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephroprotective Activity of Methanolic Extract of Lantana camara and Squash (Cucurbita pepo) on Cisplatin-Induced Nephrotoxicity in Rats and Identification of Certain Chemical Constituents of Lantana camara by HPLC-ESI- MS</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant enzymes</style></keyword><keyword><style  face="normal" font="default" size="100%">Ascorbic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Creatinine</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Histological studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenyl etanoid.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/410</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">136-147</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cisplatin is a highly effective chemotherapeutic agent; its clinical use is severely limited by serious side effects as nephrotoxicity. The aim of this study is to evaluate the nephroprotective activity of defatted methanolic extract of two Egyptian plants: &lt;em&gt;Lantana camara&lt;/em&gt; and &lt;em&gt;Cucurbita pepo&lt;/em&gt; and certain fractions derived from the defatted methanolic extract of L. camara on cisplatin-induced nephrotoxicity in rats. Also, identification of certain chemical constituents of &lt;em&gt;L. camara&lt;/em&gt; by HPLC-ESI- MS. &lt;strong&gt;Methods:&lt;/strong&gt; Nephrotoxicity was induced in rats by single dose of cisplatin. The effect of plants extract at doses 100-400 mg/kg.b.wt comparing with standard; ascorbic acid; was determined using serum urea, creatinine and some ions. Furthermore, the effect of these extracts on some renal antioxidant enzymes and histopathological examination of kidneys were examined. &lt;strong&gt;Results:&lt;/strong&gt; The defatted methanolic extract and ethyl acetate fraction of &lt;em&gt;L. camara&lt;/em&gt; showed the highest improvement of renal parameters. Also, HPLC-ESI-MS analysis of &lt;em&gt;L. camara&lt;/em&gt; extracts exhibited bioactive phenolic compounds including phenyl ethanoid, flavonoids and phenolic acids. &lt;strong&gt;Conclusion:&lt;/strong&gt; The phytochemical constituents of &lt;em&gt;L. camara &lt;/em&gt;are responsible for their nephroprotective activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">136</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Heba Abdel-Hady&lt;sup&gt;1&lt;/sup&gt;*, Mortada Mohamed El-Sayed&lt;sup&gt;1&lt;/sup&gt; , Afaf Ahmed Abdel-Hady&lt;sup&gt;2&lt;/sup&gt;, Maher Mahmoud Hashash&lt;sup&gt;3&lt;/sup&gt;, Ahmed Mohamed Abdel-Hady&lt;sup&gt;4&lt;/sup&gt;, Tarek Aboushousha&lt;sup&gt;4&lt;/sup&gt;, El-Sayed Saleh Abdel-Hameed&lt;sup&gt;1&lt;/sup&gt;, Ezzat El-Sayed Abdel-Lateef&lt;sup&gt;1&lt;/sup&gt;, Eman Abdalla Morsi&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;ClinicalChemistry Department, Theodor Bilharz Research Institute, Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry, Faculty of Science, Ain Shams University, , Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Pathology Department, Theodor Bilharz Research Institute, , Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nair Aiswarya</style></author><author><style face="normal" font="default" size="100%">Rao Rashmi R</style></author><author><style face="normal" font="default" size="100%">Shenoy Preethi J</style></author><author><style face="normal" font="default" size="100%">Vinod Chandran</style></author><author><style face="normal" font="default" size="100%">S Teerthanath</style></author><author><style face="normal" font="default" size="100%">Pai Sunil B</style></author><author><style face="normal" font="default" size="100%">KB Rakesh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephroprotective Effect of Aqueous Extract of Pimpinella anisum in Gentamicin Induced Nephrotoxicity in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aniseed</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug induced nephrotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Gentamicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Pimpinella anisum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/532</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">403-407</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Pimpinella anisum&lt;/em&gt; known for its various medicinal properties is also a natural antioxidant and a free radical scavenger with no documented evidence as a nephroprotective agent. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the nephroprotective activity of aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; seeds in a rodent model of gentamicin induced nephrotoxicity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Wistar albino rats of either sex, weighing 150&amp;ndash;200 g was divided into 5 groups; normal saline, gentamicin 80mg/kg, intraperitoneally for 8 days, aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; seeds at 1, 2, and 4g/kg, per oral for 8 days, the test extract administered 3 days prior and concurrently with gentamicin for 5 days. Blood urea, serum creatinine, uric acid and blood urea nitrogen analyses and microscopic examination of kidney were performed. &lt;strong&gt;Results:&lt;/strong&gt; Gentamicin treatment caused nephrotoxicity as evidenced by marked elevation in serum urea, serum uric acid, serum creatinine and blood urea nitrogen (107.5&amp;plusmn;16.92mg/dl, 0.8&amp;plusmn;0.09 mg/dl, 3.05&amp;plusmn;0.29 mg/dl, 47.8&amp;plusmn;9.07 mg/dl) respectively when compared to the saline treated groups. Co-administration of &lt;em&gt;Pimpinella anisum&lt;/em&gt; extract with gentamicin decreased the rise in these parameters in a dose dependent manner. Histopathological analysis revealed epithelial loss with intense granular degeneration in gentamicin treated rats, whereas aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; mitigated the severity of gentamicin-induced renal damage. &lt;strong&gt;Conclusion:&lt;/strong&gt; To conclude, our data suggest that aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; exhibits renoprotective effect in gentamicin induced renal damage and further studies on its mechanism of action are warranted.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">403</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nair Aiswarya&lt;sup&gt;1&lt;/sup&gt;, Rao Rashmi R&lt;sup&gt;1*&lt;/sup&gt;, Shenoy Preethi J&lt;sup&gt;1&lt;/sup&gt;, Vinod Chandran&lt;sup&gt;2&lt;/sup&gt;, S Teerthanath&lt;sup&gt;3&lt;/sup&gt;, Pai Sunil B&lt;sup&gt;1&lt;/sup&gt;, KB Rakesh&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pathology, K S Hegde Medical Academy, Nitte University, Deralakatte, Mangalore, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sherry Aristyani</style></author><author><style face="normal" font="default" size="100%">Sri Widyarti</style></author><author><style face="normal" font="default" size="100%">Sutiman Bambang Sumitro</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Network Analysis of Indigenous Indonesia Medical Plants for Treating Tuberculosis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytoscape</style></keyword><keyword><style  face="normal" font="default" size="100%">Immune system</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesia medical plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Network</style></keyword><keyword><style  face="normal" font="default" size="100%">Tuberculosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1159-1164</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Indonesia is the biggest archipelago country with the second biggest biodiversity in the world. A lot of medical plants for treating various diseases can be found in Indonesia, including medical plants for tuberculosis, an infectious disease caused by &lt;em&gt;Mycobacterium tuberculosis&lt;/em&gt;. &lt;strong&gt;Objective:&lt;/strong&gt; The goal of this research is to document the information of Indonesia indigenous medical plants that used various local societies to treat tuberculosis and also analyze active compounds of medical plants with proteins that related to tuberculosis. &lt;strong&gt;Methods and Material:&lt;/strong&gt; The annotation of medical plants for treating tuberculosis was collected from a various source comprising local research papers, theses, and other resources. The information of active compound was taken from Dr. Duke&amp;rsquo;s Phytochemical and Ethnobotanical Databases. A network of active compounds-proteins was analyzed by using Cytoscape 3.6.0. &lt;strong&gt;Results:&lt;/strong&gt; The result described that there were twenty-seven species from nineteen families of medical plants used by local societies of Indonesia for tuberculosis therapy, and there were sundry of active compounds from fourteen medical plants had direct interaction with proteins related tuberculosis. &lt;strong&gt;Conclusions:&lt;/strong&gt; Most of the active compounds targeted proteins that had a prominent role in immune system. It indicated that medical plants treating tuberculosis through regulating immunity of human body.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1159</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sherry Aristyani, Sri Widyarti, Sutiman Bambang Sumitro*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, University of Brawijaya, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bhupesh Chander Semwal</style></author><author><style face="normal" font="default" size="100%">Madhuri Verma</style></author><author><style face="normal" font="default" size="100%">Yogesh Murti</style></author><author><style face="normal" font="default" size="100%">Harlokesh Narayan Yadav</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Activity of Sesbania grandifolara Seeds Extract Against Celecoxib Induced Amnesia in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetylcholine</style></keyword><keyword><style  face="normal" font="default" size="100%">Celecoxib</style></keyword><keyword><style  face="normal" font="default" size="100%">Free radical</style></keyword><keyword><style  face="normal" font="default" size="100%">Morris water maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Sesbania grandiflora</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/663</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">747-752</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Sesbania grandiflora&lt;/em&gt; are characterized by their high anti-oxidant properties. The degeneration of neurons in Alzheimer disease mainly occurs because of high production of free radicals. However, the impact of &lt;em&gt;Sesbania grandiflora&lt;/em&gt; on cholinergic system and oxidative stress parameter has not been investigated. &lt;strong&gt;Aim:&lt;/strong&gt; The present study was designed to evaluate the neuroprotective effect of ethanolic extract of &lt;em&gt;Sesbania grandiflora&lt;/em&gt; seeds in mice. &lt;strong&gt;Material and method:&lt;/strong&gt; The seeds of &lt;em&gt;Sesbania grandiflora&lt;/em&gt; were powdered and subjected to successive extraction in Soxhlet apparatus. The different doses of ethanolic extract of &lt;em&gt;Sesbania grandiflora&lt;/em&gt; seeds were evaluated for its neuroprotective activity against celecoxib induced amnesia in mice. &lt;strong&gt;Result and Conclusion:&lt;/strong&gt; Phytochemical analysis of various extracts of &lt;em&gt;Sesbania grandiflora&lt;/em&gt; revealed the presence of steroid, saponin, flavonoid, tannins and phenolic compounds. The ethanolic extract of &lt;em&gt;Sesbania grandiflora&lt;/em&gt; significantly improves the memory of mice and reestablishes the amnesia induced by celecoxib. In addition to improvement in memory the extract treatment also decreases the activity of AchE and MDA and restore the antioxidant anzyme SOD, GSH and catalase in experimental animals. The results of our study showed that ethanolic extract of &lt;em&gt;Sesbania grandiflora&lt;/em&gt; improve the cognition dysfunction in celecoxib treated mice through the modification in cholinergic system or by the blockage of oxidative stress and inhibition of AchE enzyme.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">747</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Bhupesh Chander Semwal&lt;sup&gt;1&lt;/sup&gt;*, Madhuri Verma&lt;sup&gt;1&lt;/sup&gt;, Yogesh Murti&lt;sup&gt;1&lt;/sup&gt;, Harlokesh Narayan Yadav&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology Institute of Pharmaceutical Research GLA University, Mathura, U.P, India -281406, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;All India Institute of Medical Sciences, New Delhi, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aslam Pathan</style></author><author><style face="normal" font="default" size="100%">Abdulrahman Alshahrani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effects of Valeriana wallichii on Scopolamine Induced Learning and Memory Impairment in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alzheimer’s disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Elevated Plus Maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Scopolamine</style></keyword><keyword><style  face="normal" font="default" size="100%">Valeriana wallichii</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s38-s41</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Alzheimer&amp;rsquo;s disease (AD) is the most common cause of dementia in worldwide, treatment options is extremely limited and costly. The present study was conducted to investigate and validate the traditional claim of &lt;em&gt;Valeriana wallichii&lt;/em&gt; on scopolamine treated rats as an AD model. &lt;strong&gt;Methods:&lt;/strong&gt; The &lt;em&gt;Valeriana wallichii&lt;/em&gt; rhizome ethanol extract (25 mg/kg/day) was administered daily along with scopolamine for a period of 14 days following which the elevated plus maze test were performed to assess learning and memory. Rats treated with scopolamine or vehicle only were also included in the experiment. &lt;strong&gt;Result:&lt;/strong&gt; The study demonstrate that scopolamine treatment resulted in learning and memory deficits which were partially and significantly ameliorated by the &lt;em&gt;Valeriana wallichii&lt;/em&gt; rhizome ethanol extract.&lt;strong&gt; Conclusion:&lt;/strong&gt; The study demonstrates the ability of the&lt;em&gt; Valeriana wallichii&lt;/em&gt; rhizome ethanol extract to reverse scopolamine-induced learning and memory deficits in rats.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s38</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aslam Pathan&lt;sup&gt;1,*&lt;/sup&gt;, Abdulrahman Alshahrani&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Therapeutics College of Medicine, Shaqra University, Ministry of Higher Education, Shaqra-11961, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Internal Medicine (Neurology), College of Medicine, Shaqra University, Ministry of Higher Education, Shaqra-11961, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wannachai Chatan</style></author><author><style face="normal" font="default" size="100%">Wilanwan Promprom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">New Medicinal Plant Variety of Trichosanthes tricuspidata Lour. (Cucurbitaceae) from Northeastern Thailand</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cucurbitaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Taxonomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Thailand</style></keyword><keyword><style  face="normal" font="default" size="100%">Trichosanthes tricuspidata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/361</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">29-32</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; This research was carried out for describing, illustrating and treating a new medicinal plant variety in the genus &lt;em&gt;Trichosanthes&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; This research was carried out by collecting plant specimens in the Northeastern Thailand. Morphological characters were studied and compared with the closely related taxon and taxonomic literatures. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;T. tricuspidata&lt;/em&gt; subsp. &lt;em&gt;rotundata&lt;/em&gt; var. &lt;em&gt;longirachis&lt;/em&gt;, was found. This plant is described and illustrated here and treated as a new variety. It differs from the other of &lt;em&gt;T. tricuspidata&lt;/em&gt; subsp. &lt;em&gt;rotundata&lt;/em&gt; by having the following combination characters: Comparatively stout herbaceous climber up to 20 m long, tendril 3&amp;ndash;5-brached, probract obovate with obvious glands, mature blade unlobed or 3-shallowly lobed with 1-2 short angles, blade not deeply lobed (unlobed blade found in juvenile plants), blade size 5-11 cm diameter and raceme rachis length 10&amp;ndash;130 cm. Its fruits and seeds were used as medicinal parts. &lt;strong&gt;Conclusion:&lt;/strong&gt; Totally, three subspecies and four variety of &lt;em&gt;T. tricuspidata&lt;/em&gt; in Thailand have been recorded so far. Important comparative morphological characters with some closely related variety are discussed. The local people used it as medicinal plant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">29</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Wannachai Chatan*, Wilanwan Promprom &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Biology, Faculty of Science, Mahasarakham University, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sri Kumalaningsih</style></author><author><style face="normal" font="default" size="100%">Muhammad Arwani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nutritious Pure Herbal Whitening Sun Cream Processed from Seed and Leaf of Moringa oleifera Fortified with Red Rice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Herbal</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Red Rice</style></keyword><keyword><style  face="normal" font="default" size="100%">Sun Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">ZnO</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/401</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">77-80</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Moringa oleifera&lt;/em&gt; seed and leaf contained available medium fatty acid profile and essential amino acid bound in the tissue which should be hydrolysed. The addition of red rice which has antioxidant compound namely ZnO that can have protected the skin from sun burn and also to make the gelatinous slurry due to reducing the moisture content. The utilization of oil seed and leaf as raw material and fortified with red rice for making a low-cost sun cream is beneficial mainly for women living at rural region. Two phases of experiments were carried out. The first phase was the effect of time and temperature on the yield and oleic acid content of the oil. A randomized block design with two factors was carried out. The temperature at three level (50, 55, 60oC) as the first factor, and the time of extraction at three levels (12, 15, 20 hours) as the second factor. It was found that treatment of 50oC at 20 hours extraction shown the best result. The yield of oil was 34% and the oleic acid content was a 71.9% from the extracted oil. A randomized block design was used to carried out the second phase of study. The time of steaming (30, 45, 60 minutes) as the first factor and the red rice concentration (5%, 10%, 15%) as the second factor. The result shown that the use of 60 minutes and 5% red rice concentration was the best result. The slurry has the moisture content of 40.4% and the protein content was 40.5%. The storage stability of the sun cream stored under low temperature (30&amp;plusmn;1oC) was 6 months and the characteristic of the slurry having oleic acid, essential amino acid and the ZnO.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">77</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sri Kumalaningsih&lt;sup&gt;1&lt;/sup&gt;, Muhammad Arwani&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Agro-industrial Technology Brawijaya University, St Veteran 65145 Malang, East Java, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Graduate Student of Agricultural Technology, Brawijaya University St Veteran 65145 Malang, East Java, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Karim Raafat</style></author><author><style face="normal" font="default" size="100%">Rawan El-Haj</style></author><author><style face="normal" font="default" size="100%">Dania Shoumar</style></author><author><style face="normal" font="default" size="100%">Rana Alaaeddine</style></author><author><style face="normal" font="default" size="100%">Yousra Fakhro</style></author><author><style face="normal" font="default" size="100%">Natalie Tawil</style></author><author><style face="normal" font="default" size="100%">Farah Shaer</style></author><author><style face="normal" font="default" size="100%">Amani Daher</style></author><author><style face="normal" font="default" size="100%">Natalie Awada</style></author><author><style face="normal" font="default" size="100%">Ali Sabra</style></author><author><style face="normal" font="default" size="100%">Khouloud Atwi</style></author><author><style face="normal" font="default" size="100%">Malak Khaled</style></author><author><style face="normal" font="default" size="100%">Raneem Messi</style></author><author><style face="normal" font="default" size="100%">Nour Abouzaher</style></author><author><style face="normal" font="default" size="100%">Mohamed Houri</style></author><author><style face="normal" font="default" size="100%">Samer Al Jallad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Current therapies</style></keyword><keyword><style  face="normal" font="default" size="100%">Diagnosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Mechanisms</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuropathy Pain</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytotherapies</style></keyword><keyword><style  face="normal" font="default" size="100%">Recommendations</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.72</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">425-434</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; One of the common syndromes that affect humanity is neuropathic pain (NP), yet poorly understood with no efficient treatment till now. Consequently, it is extremely crucial to seek further evidence for accurate diagnosis and optimum treatment. The aim of this work is to summarize the findings related to neuropathic pain in terms of etiology, types, diagnosis, current and future management prospective, and identify the gaps in neuropathic pain therapy. &lt;strong&gt;Methods:&lt;/strong&gt; A literature investigation was carried out by analyzing classical peer reviewed papers and textbooks, taking into consideration worldwide well established scientific databases mainly PUBMED and SCOPUS to retrieve accessible published literature. The selection of phytotherapies was based upon their potentials in relieving NP in pre-clinical or clinical models. &lt;strong&gt;Results:&lt;/strong&gt; One of the most critical points in this research is that recommendations of the future plans should be focused on the engagement of phytotherapy in the treatment regimen aiming at improving patients&amp;rsquo; quality of life and reaching optimum efficacy and minimum toxicity. Phytotherapies offer relatively low-risk options to NP patients and have an increasing evidence to be the future of neuropathic pain management. Patients suffering from neuropathy are depending increasingly on phytotherapies; however, they need more clinical trials in order to fully understand their mechanism of actions. &lt;strong&gt;Conclusion:&lt;/strong&gt; Health-care specialists should be regularly informed about neuropathic pain current therapies and promising future phytotherapies, bearing in mind the risk/benefit profile of the utilization of these therapies in the amelioration of NP.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">425</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Karim Raafat&lt;sup&gt;*&lt;/sup&gt;, Rawan El-Haj, Dania Shoumar, Rana Alaaeddine, Yousra Fakhro, Natalie Tawil, Farah Shaer, Amani Daher, Natalie Awada, Ali Sabra, Khouloud Atwi, Malak Khaled, Raneem Messi, Nour Abouzaher, Mohamed Houri and Samer Al Jallad &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, 115020 Beirut, LEBANON,&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Swaminathan Gomathi</style></author><author><style face="normal" font="default" size="100%">Rajagopal Shanmuga Sundaram</style></author><author><style face="normal" font="default" size="100%">Vellaichamy Muthupandi Annapandian</style></author><author><style face="normal" font="default" size="100%">Manickam Vijayabaskaran</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effect of Pedalium murex Linn. Leaf against Lipopolysaccharide Induced Behavioural Disorders in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Behavioural studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Learning</style></keyword><keyword><style  face="normal" font="default" size="100%">Memory</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Pedalium murex.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">957-962</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Effective treatment is necessary to minimize the neuronal damage and oxidative stress. Traditional medicines offer potent pharmacological activity with minimal side effects compared to synthetic drugs to treat such chronic disorders. There is no renowned remedy for arrest or rescuing infection or inflammation-induced brain damage. The present study was aimed to evaluate the neuroprotective effect of ethanol extract of &lt;em&gt;Pedalium murex&lt;/em&gt; Linn. (EEPM) leaves against lipopolysaccharide (LPS)-induced endotoxemia. &lt;strong&gt;Methods:&lt;/strong&gt; Neurodegeneration was induced in rats with a single intraperitoneal injection of LPS (1 mg/kg). The induced endotoxemia constantly linked with battery of behavioural tests viz., choice reaction time task (CRT), 8-arm radial maze (RAM) and water maze test (WMT). At the end of the study, rats were sacrificed, brain hippocampal region was removed and biochemical parameters were measured. &lt;strong&gt;Results:&lt;/strong&gt; In WMT swimming length (cm) was increased in LPS-treated rats when compared to control animals, the swimming length (EEPM; 400 mg/kg) was found to be significant; in RAM, different doses of EEPM at 100, 200 and 400 mg/kg decreased the number of errors in entry 4.00&amp;plusmn;0.36, 4.16&amp;plusmn;0.16and 3.33&amp;plusmn;2.79 respectively when compared with control animals (2.66&amp;plusmn; 0.21). EEPM at 400 mg/kg showed significant activity, in CRT apparatus increased incorrect lever pressing was observed in LPS-treated rats when compared to control animals. Incorrect lever pressing was minimized by EEPM at 400 mg/kg (43.5&amp;plusmn;2.40). &lt;strong&gt;Conclusions:&lt;/strong&gt; Our results showed that EEPM is a hopeful aspirant for hindrance of infection and inflammation induced brain damage by LPS.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">957</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Swaminathan Gomathi&lt;sup&gt;1&lt;/sup&gt;, Rajagopal Shanmuga Sundaram&lt;sup&gt;2*&lt;/sup&gt;, Vellaichamy Muthupandi Annapandian&lt;sup&gt;2&lt;/sup&gt;, Manickam Vijayabaskaran&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry and JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu &amp;ndash; 638183, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Chemistry and JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu &amp;ndash; 638183, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meenu Bhan</style></author><author><style face="normal" font="default" size="100%">Saurabh Satija</style></author><author><style face="normal" font="default" size="100%">Chanchal Garg</style></author><author><style face="normal" font="default" size="100%">Harish Dureja</style></author><author><style face="normal" font="default" size="100%">Munish Garg</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Novel Approach towards Green Extraction for Glycyrrhitinic Acid by Ionic Liquid Based Microwave Assisted Extraction and Optimization through Response Surface Methodology</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Glycyrrhitinic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycyrrhiza glabra</style></keyword><keyword><style  face="normal" font="default" size="100%">Microwave assisted extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Novel</style></keyword><keyword><style  face="normal" font="default" size="100%">Response surface methodology.</style></keyword><keyword><style  face="normal" font="default" size="100%">[bmim]Cl</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/189</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">866-872</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Extraction process plays an important role in extraction of herbal bioactive components. Ionic liquid based microwave assisted extraction (IL-MAE) has the potential to yield maximum analytes from the crude drugs in shorter time period with less solvent consumption and greater efficiency. &lt;strong&gt;Objective:&lt;/strong&gt; The present study aimed to develop new protocol of Ionic Liquids based Microwave-assisted Extraction (ILs-MAE) of glycyrrhetinic acid from licorice; optimization of the protocol through RSM and comparison of IL-MAE with conventional extraction techniques like maceration and soxhlation by HPTLC. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; A novel ionic liquid-based microwave assisted extraction (IL-MAE) method was carried out for glycyrrhitinic acid from &lt;em&gt;Glycyrrhiza glabra &lt;/em&gt;using ionic liquid, 1-butyl-3-methyl-imidazolium chloride ([bmim]Cl) and optimized by response surface methodology. The variable microwaveassisted extraction parameters selected were concentration of [bmim]Cl, extraction time and microwave power while solid-liquid ratio and extraction temperature were kept constant. Response surface methodology was applied for developing, improving and optimizing the whole process and comparison of IL-MAE with maceration and soxhlation by HPTLC. &lt;strong&gt;Results:&lt;/strong&gt; The yield of glycyrrhitinic acid was found to be 0.48 % w/w in maceration in 7 days, 0.76 % in soxhlation in 3 h and 2.54 % w/w in IL-MAE in 4 min. &lt;strong&gt;Conclusion:&lt;/strong&gt; IL- MAE of glycyrrhitinic acid from &lt;em&gt;Glycyrrhiza glabra&lt;/em&gt; was proved to be better in respect of extraction efficiency, time and quantity of solvent used. Meanwhile, there was great reduction in the environmental pollution by using the green solvents/ ionic liquids (ILs), which is a great benefit to all.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">866</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Meenu Bhan&lt;sup&gt;1&lt;/sup&gt;, Saurabh Satija&lt;sup&gt;2&lt;/sup&gt;, Chanchal Garg&lt;sup&gt;1&lt;/sup&gt;, Harish Dureja&lt;sup&gt;1&lt;/sup&gt;, Munish Garg&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, INDIA. &lt;sup&gt;2&lt;/sup&gt;Assistant Professor School of Pharmaceutical Sciences Lovely Professional University, Punjab, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anjusha Sudhakaran</style></author><author><style face="normal" font="default" size="100%">Gangaprasad Appukuttan Nair</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nutritional Evaluation of Fruits of Gynochthodes umbellata (L.) Razafim. &amp; B. Bremer – An Underutilized Edible Fruit Plant</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-nutritional analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda umbellata</style></keyword><keyword><style  face="normal" font="default" size="100%">Nutritional analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Underutilized edible fruit.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">72-76</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present investigation aimed to assess the nutritional, mineral profiling and anti-nutritional analysis of &lt;em&gt;Gynochthodes umbellata&lt;/em&gt; (Syn. &lt;em&gt;Morinda umbellata&lt;/em&gt;), an underutilized edible plant belongs to the family Rubiaceae. Literature perusal reveals that, there are no previous reports on nutritional studies for this valuable fruit. &lt;strong&gt;Methods:&lt;/strong&gt; Nutritional, mineral profiling and anti-nutritional analysis of fruits were carried out. Results: In nutritional analysis, carbohydrates (6.98 g/100g fw), protein (2.68 g/100 g fw), crude fat (0.13 mg/g dw) and crude fibre (32.58%) content were detected. The fruits of &lt;em&gt;G. umbellata&lt;/em&gt;, Vitamin C (25 mg/100g fw) was higher when compared to other three vitamin evaluated, Four macro elements and 6 micro elements were also quantified. &lt;strong&gt;Conclusion: &lt;/strong&gt;Nutritional and Anti-nutritional analysis reveals that, the &lt;em&gt;G. umbellata&lt;/em&gt; fruits could be used as a source of protein, vitamin and minerals and highly recommended for consumption as they contain low amount of the anti&amp;ndash;nutrients analysed. This is the first report on nutritional analysis of &lt;em&gt;G. umbellata&lt;/em&gt; fruit.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">72</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Anjusha Sudhakaran and Gangaprasad Appukuttan Nair&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Botany, University of Kerala, Kariyavattom Campus, Thiruvananthapuram, Kerala, 695581, India.&lt;/p&gt;</style></auth-address></record></records></xml>