<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Erich Christian Wayangkau</style></author><author><style face="normal" font="default" size="100%">Budiyono Budiyono</style></author><author><style face="normal" font="default" size="100%">Martini Martini</style></author><author><style face="normal" font="default" size="100%">Mursid Raharjo</style></author><author><style face="normal" font="default" size="100%">Bagoes Widjanarko</style></author><author><style face="normal" font="default" size="100%">Daru Lestantyo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of the UFESA Model: A Culturally Grounded Intervention to Improve Adherence to Lymphatic Filariasis Mass Drug Administration in Papua, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">adherence</style></keyword><keyword><style  face="normal" font="default" size="100%">Filariasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Local culture</style></keyword><keyword><style  face="normal" font="default" size="100%">mass drug administration</style></keyword><keyword><style  face="normal" font="default" size="100%">psychometric testing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">55-62</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Lymphatic filariasis remains a public health challenge in Papua because of low adherence to mass drug administration (MDA). Objective: This study evaluated the effectiveness of the UFESA model—a culturally tailored intervention integrating health education, family support, and traditional leader engagement—in improving adherence to preventive filariasis medication in Sarmi District. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;A quasiexperimental pretest–posttest control group design was implemented across two health centers (intervention: Bagaiserwar; control: Sarmi Kota), with 160 participants recruited via multistage random sampling. The primary outcome was adherence across three MDA cycles; secondary outcomes included knowledge, attitudes, and support measures. The data were analyzed via chi-square, Mann– Whitney U, and Wilcoxon tests. &lt;strong&gt;Results: &lt;/strong&gt;Adherence increased from 38.8% to 87.5% in the intervention group, whereas it increased from 26.2% to 52.5% in the control group (&lt;em&gt;p &lt;/em&gt;&amp;lt; 0.001). All the adherence dimensions were significantly greater in the intervention group. Knowledge increased from 3.00 to 10.00 (intervention) versus 2.00 to 4.00 (control), with similar improvements in attitudes and support (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.001). The instruments showed strong reliability (α &amp;gt; 0.80) and validity. The effect sizes were medium to large (Cohen's d=0.68–0.78; Cramer's V=0.38–0.45).&lt;strong&gt; Conclusion: &lt;/strong&gt;The findings provide evidence of the effectiveness of the UFESA model in enhancing medication adherence and addressing psychosocial determinants, highlighting the value of culturally grounded, psychometrically rigorous interventions in public health.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">55</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Erich Christian Wayangkau&lt;sup&gt;1,2*&lt;/sup&gt;, Budiyono Budiyono&lt;sup&gt;3&lt;/sup&gt;, Martini Martini&lt;sup&gt;4&lt;/sup&gt;, Mursid Raharjo&lt;sup&gt;3&lt;/sup&gt;, Bagoes Widjanarko&lt;sup&gt;5&lt;/sup&gt;, Daru Lestantyo&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Public Health, Diponegoro University, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Public Health, Cenderawasih University, Jayapura, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Diponegoro University, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Diponegoro University, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Health Promotion and Behavioral Science, Faculty of Public Health, Diponegoro University, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health, Diponegoro University, Semarang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hareg Zewdu Alehegn</style></author><author><style face="normal" font="default" size="100%">Abiodun A. Adeyemi</style></author><author><style face="normal" font="default" size="100%">Abayomi Mayowa Ajayi</style></author><author><style face="normal" font="default" size="100%">Foluke A. Fasola</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Phytochemical, Antioxidant, Anti-sickling, and Membrane Stabilization Properties of Justicia carnea Leaves and Stems Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Sickle Cell Disease</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">1-7</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sickle cell disease (SCD) is an autosomal recessive inherited genetic blood disorder resulting from the aberrant structure of hemoglobin (Hb) that results in the production of hemoglobin S (Hb S). Objective: This study aimed to investigate the phytochemical profiles, antioxidant, anti-sickling, and membrane stabilizing activities of crude extracts of &lt;em&gt;Justicia carnea &lt;/em&gt;leaves and stems that used to treat SCD in Nigeria. &lt;strong&gt;Methods:&lt;/strong&gt; The 70 % ethanol crude extracts of the dried, powdered leaves and stems of &lt;em&gt;J. carnea&lt;/em&gt; were prepared by maceration. Reversal and inhibition activity of the plant materials were evaluated by using sodium-metabisulphite-sickled HB SS blood cells from two patients not in crisis. The membrane stabilization assays on rats' red blood cells (RBCs) and human sickled RBCs and antioxidant assays were determined following standard methods. Results were presented as Mean ± SEM. Data analysis and graph plotting were carried out using GraphPad Prism® version 8.01.&lt;strong&gt; Results:&lt;/strong&gt; The antioxidant assays indicated that &lt;em&gt;J. carnea&lt;/em&gt; leaves (JCL) had stronger DPPH activity (IC₅₀ = 245.031 ± 0.228 μg/mL). While, the stems (JCS) exhibited higher NO scavenging (84.123 ± 0.497 μg/mL). The highest reversal and inhibition percentages observed at 60, 90, and 120-minute time points. At 60th minutes reading, JCL 20 mg/mL (78.9±0.13%) demonstrated the highest reversal activity, while JCL 10 mg/mL (66.9±0.82 %) revealed the strongest inhibition effect. The extracts showed dose-dependent membrane stabilization activity. &lt;strong&gt;Conclusions: &lt;/strong&gt;The extracts demonstrated remarkable antioxidant, anti-sickling, and membrane stabilizing activities. The use of this plant could be a promising natural therapy for SCD.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hareg Zewdu Alehegn&lt;sup&gt;1,2*&lt;/sup&gt;, Abiodun A. Adeyemi&lt;sup&gt;3&lt;/sup&gt;, Abayomi Mayowa Ajayi&lt;sup&gt;4&lt;/sup&gt;, Foluke A. Fasola&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;M.Sc. Candidate, Medicinal Plants Research and Drug Development, Pan African University, Life and Earth Sciences Institute (Including Health and Agriculture), Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, ETHIOPIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Senior Lecturer, Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Senior Lecturer, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Reader/Consultant Haematologist Department of Haematology, College of Medicine, University of Ibadan/University College Hospital, Ibadan, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aasia Kanwal</style></author><author><style face="normal" font="default" size="100%">Muhammad Hamdi Mahmood</style></author><author><style face="normal" font="default" size="100%">Mahad Butt</style></author><author><style face="normal" font="default" size="100%">Hidayat Ur Rahman</style></author><author><style face="normal" font="default" size="100%">Norhida Ramli</style></author><author><style face="normal" font="default" size="100%">Saiful Bahri Talip</style></author><author><style face="normal" font="default" size="100%">Showkat Ahmad Bhawani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Components of Gamma Oryzanol on Toll-Like Receptor 4: Receptor Structure-Based Pharmacophore, Hit Identification, and In Silico Evidence</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Gamma oryzanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Infertility</style></keyword><keyword><style  face="normal" font="default" size="100%">Polycystic ovarian syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">TLR4 antagonist</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">329-335</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Polycystic ovarian syndrome is a leading cause of female infertility. Inflammation has a central role in infertility. Persistent activation of Toll-like receptor 4 contributes to inflammation in PCOS. Gamma-oryzanol consists of esters of ferulic acid combined with phytosterols and triterpene alcohol derivatives of rice bran oil, and is known to have anti-inflammatory effects. However, the structural interaction of different gamma-oryzanol compounds with TLR4 remains unknown. &lt;strong&gt;Objectives: &lt;/strong&gt;The study aimed to investigate gamma oryzanol compounds as hit compounds and inhibitors of Toll-like receptor 4 by developing a pharmacophore model through a receptor structure-based approach coupled with molecular docking studies with the Molecular Operating Environment (MOE) software. &lt;strong&gt;Methods: &lt;/strong&gt;A structure-based pharmacophore model was generated from the co-crystalized structure of the TLR4– MD2 complex. Gamma-oryzanol derivatives were evaluated against the constructed pharmacophore model to identify potential hit compounds. The potential hit compounds that satisfied essential pharmacophoric features were subjected to molecular docking with TLR4. &lt;strong&gt;Results:&lt;/strong&gt; The pharmacophore consisted of three characteristics: a hydrogen bond donor, a hydrogen bond acceptor, and a hydrophobic. Cycloartenyl ferulate, 24-methylenecycloartenyl ferulate, Campesteryl ferulate, and β-sitosteryl ferulate were found to be the hit compounds against the generated pharmacophore. The docking experiment showed that Cycloartenyl ferulate had the most potent binding interaction with TLR4 (7.9933), followed by 24-methylenecycloartenyl ferulate (-7.8580), Campesteryl ferulate (-6.1675), and β-sitosteryl ferulate (-5.9673). &lt;strong&gt;Conclusion: &lt;/strong&gt;The present pharmacophore modeling and docking findings predict that gammaoryzanol may bind with the TLR4 ligand binding domain, providing structural insights into their therapeutic potential role as a modulator of the TLR4-mediated inflammatory pathway. These findings provide a theoretical foundation for future in vitro and in vivo validation studies aimed at elucidating the mechanistic basis of gamma-oryzanol’s anti-inflammatory activity in PCOS.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">329</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aasia Kanwal&lt;sup&gt;1*&lt;/sup&gt;, Muhammad Hamdi Mahmood&lt;sup&gt;1&lt;/sup&gt;, Mahad Butt&lt;sup&gt;2&lt;/sup&gt;, Hidayat Ur Rahman&lt;sup&gt;1&lt;/sup&gt;, Norhida Ramli&lt;sup&gt;1&lt;/sup&gt;, Saiful Bahri Talip&lt;sup&gt;1&lt;/sup&gt;, Showkat Ahmad Bhawani&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine &amp;amp; Health Sciences, Universiti Malaysia Sarawak, 94300 Kota Samarahan, MALAYSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medicine, Allama Iqbal Medical College, 54550 Lahore, PAKISTAN. 3Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vivian Nathaly Echegaray Florian</style></author><author><style face="normal" font="default" size="100%">Claudia Giuliana Montoya Sisniegas</style></author><author><style face="normal" font="default" size="100%">Juan Ernesto Valdiviezo-Campos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Different Extraction Solvents on the Total Phenolic Content and Antioxidant Activity of Brassica oleracea var. italica</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Broccoli</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenol</style></keyword><keyword><style  face="normal" font="default" size="100%">Vegetable</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">58-62</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study offers an alternative solution for the prevention and/or treatment of diseases caused by free radicals. The objective was to evaluate the effect of different solvents on the total phenolic content and antioxidant activity of Brassica oleracea var. italica (broccoli). &lt;strong&gt;Methods: &lt;/strong&gt;The sample, consisting of stems and florets of Brassica oleracea var. italica (broccoli), were collected from the Chocas community in Carabayllo, Lima, Peru. Three extracts were prepared using different solvents, including a mixture of ethanol and water. The total phenolic content was determined using the Folin-Ciocalteu method, and antioxidant capacity was evaluated using two specific assays (DPPH and ABTS). Additionally, the correlation between total phenolic content and antioxidant activity was analyzed. &lt;strong&gt;Results:&lt;/strong&gt; The hydroethanolic extract demonstrated the highest phenolic content, with 686.02 mg GAE/100 g dry matter). It also exhibited strong antioxidant activity, measuring 1035.81 mg TE/100 g DM in the DPPH assay and 6506.94 mg TE/100 g DM in the ABTS assay. &lt;strong&gt;Conclusion: &lt;/strong&gt;The highest total phenolic content and antioxidant activity of Brassica oleracea var. italica were found in the hydroethanolic extract, which showed a significant high correlation. Frequent consumption of broccoli in the diet is recommended due to its high values.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">58</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vivian Nathaly Echegaray Florian&lt;sup&gt;1&lt;/sup&gt;, Claudia Giuliana Montoya Sisniegas&lt;sup&gt;1&lt;/sup&gt;, Juan Ernesto Valdiviezo-Campos&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Estudiante de la Escuela de Nutrición, Facultad de Ciencias de la Salud, Universidad César Vallejo, Av. Larco 1770, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Grupo de investigación en Productos Naturales. Escuela de Nutrición, Universidad César Vallejo, Av. Larco 1770, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MM Litabe</style></author><author><style face="normal" font="default" size="100%">M Matsabisa</style></author><author><style face="normal" font="default" size="100%">FJ Burt</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of PHELA, an African traditional drug, on levels of selected inflammatory cytokines in mammalian cells infected with SARSCoV- 2</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">African traditional medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">immune-modulating</style></keyword><keyword><style  face="normal" font="default" size="100%">PHELA</style></keyword><keyword><style  face="normal" font="default" size="100%">proinflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">552-565</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a severe illness, often characterized by an excessive release of proinflammatory cytokines, leading to a cytokine storm associated with disease severity. In this study the effect of PHELA, an accepted herbal combination of four exotic African medicinal plants, namely; Clerodendrum glabrum E. Mey. Lamiaceae, Gladiolus dalenii van Geel, Rotheca myricoides (Hochst.) Steane &amp;amp; Mabb, and Senna occidentalis (L.) Link, was investigated to determine the effect on viral replication of SARS-CoV-2 Omicron infected mammalian cells and the effect on cytokine release. PHELA has previously been proposed for use as an immune booster. In this study mammalian cells were treated with plant extracts before or after infection with SARS-CoV-2. Viral RNA was measured at intervals and selected cytokine levels (IL-1β, IL-2Rα, IL-6, TNF-α, IFN-γ) were monitored. No significant difference in viral RNA was observed between infected cells treated with plant extracts and untreated infected cells. However, PHELA-treated cells showed a delay in viral RNA increase. Infected cells treated with PHELA exhibited significantly lower levels of IL-1β, IL-2Rα, and TNF-α compared to untreated infected cells at 48- and 72-hours post-infection. Post-treatment was more effective in reducing proinflammatory cytokine production than pre-treatment, highlighting the potential of PHELA and its constituents in modulating cytokine responses during SARS-CoV-2 infection.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">552</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;MM Litabe&lt;sup&gt;1&lt;/sup&gt;, M Matsabisa&lt;sup&gt;2&lt;/sup&gt;, FJ Burt&lt;sup&gt;1,3*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Virology, Faculty of Health Sciences, University of the Free State, Bloemfontein, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Health Sciences, University of the Free State, Bloemfontein, SOUTH AFRICA. 3Division of Virology, National Health Laboratory Service, Bloemfontein, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Winda Noer Oktavia</style></author><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author><author><style face="normal" font="default" size="100%">Agung Putra</style></author><author><style face="normal" font="default" size="100%">Mochamad Navi Suharto</style></author><author><style face="normal" font="default" size="100%">Raja Faisal Manganju Sitorus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Tender Coconut Water on the Expression of Vascular Endothelial Growth Factor (VEGF) and Macrophage Type-1 (M1) in Hyperlipidemic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hyperlipidemia</style></keyword><keyword><style  face="normal" font="default" size="100%">M1 quantity</style></keyword><keyword><style  face="normal" font="default" size="100%">Tender coconut water</style></keyword><keyword><style  face="normal" font="default" size="100%">VEGF expression</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">277-281</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Individuals with hyperlipidemia have an increased risk of developing cardiovascular disease compared to those with normal total cholesterol levels. High-fat intake can increase cholesterol esters, especially low-density lipoprotein (LDL), triglycerides, and Reactive Oxygen Species (ROS) levels. This causes adipocyte death, infiltration of macrophage type-1 (M1) expression and release of pro-inflammatory cytokines from M1 such as Interleukin 6 (IL-6). The effect leads to apoptosis of vascular and neuronal cells as well as regulates the expression of Vascular Endothelial Growth Factor (VEGF). Tender coconut water contains antioxidants with the ability to prevent ROS, as well as reduce PKC activation, AGEs formation, and VEGF expression. &lt;strong&gt;Objective: &lt;/strong&gt;To determine the effect of tender coconut water on VEGF and M1 expression in hyperlipidemic male Wistar rats. &lt;strong&gt;Method: &lt;/strong&gt;This research used an experimental design and a post-test Only Control Group Design. The number of samples was 24 rats divided into Groups K1 (healthy rats), K2 (hyperlipidemic rats), K3 (hyperlipidemic rats+ Tender coconut water 4 mL / 200grBW / day), and K4 (hyperlipidemic rats+ coconut water 8 mL / 200grBW / day), with treatment duration of 21 days. VEGF expression data were analyzed by a one-way ANOVA test. &lt;strong&gt;Results: &lt;/strong&gt;The highest and lowest average number of M1 was in K2 (28.72) and K1 (3.61). The average in K3 was lower when compared to K2 (14.66 &amp;gt;&amp;lt; 28.72). Furthermore, M1 expression in K4 was lower when compared to K3 (6.72 &amp;gt;&amp;lt; 14.66). The highest and lowest average VEGF expression was in K2 (4.58) and K1 (1.00). The average K3 was lower when compared to K2 (2.85 &amp;gt;&amp;lt; 4.58), and VEGF expression in K4 was lower than K3 (1.76 &amp;gt;&amp;lt; 2.85). &lt;strong&gt;Conclusion: &lt;/strong&gt;Tender coconut water affected VEGF expression and M1 quantity in hyperlipidemic rats&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><section><style face="normal" font="default" size="100%">277</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Winda Noer Oktavia&lt;sup&gt;1&lt;/sup&gt;, Siti Thomas Zulaikhah&lt;sup&gt;2&lt;/sup&gt;*, Agung Putra&lt;sup&gt;3&lt;/sup&gt;, Mochamad Navi Suharto&lt;sup&gt;1&lt;/sup&gt;, Raja Faisal Manganju Sitorus&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Postgraduate Magister Biomedical Science Study Program, Faculty of Medicine, Universitas Islam Sultan Agung (Unissula), Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Universitas Islam Sultan Agung (Unissula), Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Magister Biomedical Science Study Program, Faculty of Medicine, Universitas Islam Sultan Agung (Unissula); Semarang, INDONESIA. 4Komisi XIII Dewan Perwakilan Rakyat Republik, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Angel Armando Marin Raico</style></author><author><style face="normal" font="default" size="100%">Rosa Isabel Florez Carrasco</style></author><author><style face="normal" font="default" size="100%">Jesus Eduardo Rojas Jaimes</style></author><author><style face="normal" font="default" size="100%">Juana Elvira Chavez Flores</style></author><author><style face="normal" font="default" size="100%">Jose Arenas Gamio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of the Ethanolic Extract of Chuquiraga weberbaueri Tovar on Glycemia in BALB/c Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hypoglycemic Agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extracts</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">63-70</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes mellitus is one of the most prevalent diseases worldwide and is associated with many complications. While there are many drugs available to control blood glucose levels, many people cannot access them due to economic reasons. &lt;strong&gt;Object: &lt;/strong&gt;The aim of this study was to determine the hypoglycemic effect of the ethanolic extract of &lt;em&gt;Chuquiraga weberbaueri&lt;/em&gt; in mice induced with hyperglycemia. &lt;strong&gt;Methods: &lt;/strong&gt;The mice were divided into 6 groups: the first group served as a control group and was administered only physiological saline solution; the second group was induced to hyperglycemia with Alloxan. The following three groups were induced with Alloxan and additionally administered ethanolic extract of &lt;em&gt;Chuquiraga weberbaueri&lt;/em&gt; at different concentrations of 100 mg/kg, 250 mg/kg, and 500 mg/kg respectively. The last group was administered Alloxan and glibenclamide. The glucose levels were measured for each group at 2, 4, and 24 hours after administering the extracts. &lt;strong&gt;Results: &lt;/strong&gt;The phytochemical analysis of the ethanolic extracts of the leaves of &lt;em&gt;Chuquiraga weberbaueri&lt;/em&gt; showed the presence of flavonoids, tannins, alkaloids and steroids. The ethanolic extracts (100 mg/kg at 2 hours and 250 mg/kg at 2 and 4 hours) demonstrated a decrease in blood glucose compared to the control group. In the toxicity test, the comparison between the control group and the “extract” treatment group showed that no conclusive results were observed with respect to the chuquiragua extract. &lt;strong&gt;Interpretation:&lt;/strong&gt; The results of the study showed that the ethanolic extract of &lt;em&gt;Chuquiraga weberbaueri &lt;/em&gt;showed the effect of reducing blood glucose in BALB/c mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">63</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Angel Armando Marin Raico&lt;sup&gt;1&lt;/sup&gt;, Rosa Isabel Florez Carrasco&lt;sup&gt;1&lt;/sup&gt;, Jesús Eduardo Rojas Jaimes&lt;sup&gt;1,2&lt;/sup&gt;, Juana Elvira Chávez Flores&lt;sup&gt;3&lt;/sup&gt;, José Arenas Gamio&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Medicina Humana, Universidad Científica del Sur, Lima-PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias de la Salud, Universidad Privada del Norte, Lima-PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Escuela de Farmacia y Bioquímica, Universidad Norbert Wiener, Lima-PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Departamento de Patología Clínica, Hospital Guillermo Almenara Irigoyen, Lima-PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rivan Virlando Suryadinata</style></author><author><style face="normal" font="default" size="100%">Gabriel Tirtawijaya</style></author><author><style face="normal" font="default" size="100%">Sawitri Boengas</style></author><author><style face="normal" font="default" size="100%">Priscilla Keshia Jayasaputri</style></author><author><style face="normal" font="default" size="100%">Henriette Milda Latuputty</style></author><author><style face="normal" font="default" size="100%">Nisa Kirania Dianti Mulyadi</style></author><author><style face="normal" font="default" size="100%">Nawal Fajril Haya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effectiveness of Beltfish (Trichiurus lepturus) Protein Intake and Physical Activity on Muscle Mass Growth</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Malnutrition</style></keyword><keyword><style  face="normal" font="default" size="100%">Muscle Mass</style></keyword><keyword><style  face="normal" font="default" size="100%">Physical Activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Intake</style></keyword><keyword><style  face="normal" font="default" size="100%">Trichiurus lepturus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">714-717</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Malnutrition cases have increased every year. One of the causes is insufficient food intake, marked by a decrease in muscle mass. Preventing malnutrition can be done by increasing muscle mass through providing daily protein intake according to needs and engaging in physical activity. The fish species Trichiurus lepturus is a high-protein source from the sea. The protein content in this fish can help promote muscle mass growth. This study aims to determine the effectiveness of protein intake from Trichiurus lepturus combined with physical activity on increasing muscle mass. The research method is experimental, using test animals (Rattus norvegicus) given protein intake and physical activity for 28 days. The animals were divided into six groups: three control groups and three treatment groups receiving different protein levels. Muscle growth was assessed by observing the enlargement of the cruris muscle using HE (hematoxylin and eosin) staining under a 4x microscope magnification. The data obtained were analyzed using ANOVA with an Bonferroni test. The results showed a significant difference between all groups (p=0.000). The treatment groups receiving protein intake and physical activity had larger muscle sizes compared to the control groups (P≤0.05). The conclusion is that protein intake accompanied by physical activity causes changes in muscle mass. Additionally, the amount of protein intake is directly proportional to the increase in muscle size.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">714</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rivan Virlando Suryadinata&lt;sup&gt;1*&lt;/sup&gt;, Gabriel Tirtawijaya&lt;sup&gt;2&lt;/sup&gt;, Sawitri Boengas&lt;sup&gt;1&lt;/sup&gt;, Priscilla Keshia Jayasaputri&lt;sup&gt;1&lt;/sup&gt;, Henriette Milda Latuputty&lt;sup&gt;1&lt;/sup&gt;, Nisa Kirania Dianti Mulyadi&lt;sup&gt;1&lt;/sup&gt;, Nawal Fajril Haya&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, University of Surabaya, Surabaya, East Java, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Biotechnology, University of Surabaya, Surabaya, East Java, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Chairul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of Radish (Raphanus sativus) Extract In Reducing Tnf-α and Nitrit Oxida levels in Tipe II DM Mice Models with Traumatic Brain Injury</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Raphanus sativus</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword><keyword><style  face="normal" font="default" size="100%">Traumatic Brain Injury</style></keyword><keyword><style  face="normal" font="default" size="100%">Wistar rats.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">597-601</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The devastating effects of traumatic brain injury (TBI) are fatal, and there is no effective treatment for primary brain injury, especially in patients with diabetes mellitus (DM). Nitric oxide (NO) is a compound that causes systemic vasodilation; a decrease in NO reduces cerebral blood flow after TBI. There is an increase in TNF-α levels demonstrated by mononuclear cells surrounding the traumatic lesion in the rat brain. &lt;em&gt;Raphanus sativus &lt;/em&gt;(radish) is a root vegetable belonging to the Brassicaceae family, which has anti-diabetic effects by lowering blood glucose levels, reducing lipid peroxidation, and improving brain function, thereby protecting against neurotoxic effects associated with oxidative stress in experimental mouse models. &lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the efficacy of radish extract &lt;em&gt;(Raphanus sativus)&lt;/em&gt; in reducing TNF-α and nitric oxide levels in a rat model of type II diabetes mellitus with traumatic brain injury. Method: This study was an in vivo laboratory experimental study with a post-test only control group design. The study population consisted of 25 Wistar rats, which were then induced with diabetes and subjected to a modified Feeney Model closed head injury. After complete data collection, KGD and ELISA assessments were performed, followed by data analysis. &lt;strong&gt;Results: &lt;/strong&gt;There were significant differences (p&amp;lt;0.05) in serum NO and serum TNF-α levels between the normal group, the 100 mg/kg radish extract group, the 300 mg/kg radish extract group, and the 500 mg/kg radish extract group compared to the negative control group. This indicates that radish extract, starting at a dose of 100 mg/kg, can reduce serum NO and serum TNF-α levels. &lt;strong&gt;Conclusion: &lt;/strong&gt;Radish extract &lt;em&gt;(Raphanus sativus)&lt;/em&gt; is effective in reducing TNF-α and nitric oxide levels in a Wistar rat model of type II DM with traumatic brain injury.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">597</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Chairul&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Science Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Jarinyaporn Naowaboot</style></author><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Suvara Wattanapitayakul</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Citrus aurantifolia Root Ethanolic Extract on Lipogenesis in Palmitate-Induced Lipid Accumulation in HepG2 Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Citrus aurantifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Nonalcoholic fatty liver disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">77-83</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Citrus aurantifolia &lt;/em&gt;(lime) is mostly found in tropical and subtropical region. The lime peel and lime juice extracts have antioxidant, antidiabetic and anti-inflammatory effects. However, the pharmacological effects of the lime root remain widely unknown. Thus, the current study investigated the effects of &lt;em&gt;Citrus aurantifolia&lt;/em&gt; root ethanolic extract (CA) on lipogenesis induced by palmitic acid (PA) in HepG2 cells. &lt;strong&gt;Methods: &lt;/strong&gt;The PA-induced lipogenesis in HepG2 cells was used for measuring lipogenic gene expression and lipid accumulation of CA. Phytochemical content was also determined in CA. &lt;strong&gt;Results: &lt;/strong&gt;In PA-treated group showed the state of hepatic lipid accumulation with increased lipogenic gene, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS) and sterol regulatory element binding protein1c (SREBP1c) as compared to the control group. Interestingly, administration of CA (5-10 μg/mL) effectively reduced lipid storage and significantly decreased the expression of these lipogenic gene in PA-treated cells. Notably, CA treatment increased the gene expression of fatty acid oxidation, carnitine palmitoyl transferase 1A (CPT1A) and peroxisome proliferator-activated receptor α (PPARα). Furthermore, this study found that the major bioactive component from CA was nordentatin (coumarin group).&lt;strong&gt; Conclusions:&lt;/strong&gt; The results indicated that the CA treatment might be a useful agent for improving abnormal lipid metabolism in obesity-related nonalcoholic fatty liver disease.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">77</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Jarinyaporn Naowaboot&lt;sup&gt;1&lt;/sup&gt;, Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Suvara Wattanapitayakul&lt;sup&gt;3&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;4*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Erwin Mulyawan</style></author><author><style face="normal" font="default" size="100%">Clarissa Jasmine Aurelia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy and Safety of Propofol Drip versus Thiopental with Midazolam in Children Undergoing Magnetic Resonance Imaging Studies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Children</style></keyword><keyword><style  face="normal" font="default" size="100%">MRI</style></keyword><keyword><style  face="normal" font="default" size="100%">Propofol</style></keyword><keyword><style  face="normal" font="default" size="100%">Thiopental</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">289-292</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Pediatrics often require sedatives during Magnetic Resonance Imaging (MRI) due to its lengthy, loud, and restricted space. This study aims to compare efficacy and safety of propofol drip and thiopental with midazolam for children undergoing MRI. &lt;strong&gt;Methods: &lt;/strong&gt;This randomised double-blinded cohort study was conducted in patients aged 3-10 years old with ASA status I-II scheduled for outpatient MRI. Exclusion criteria include airway abnormalities, allergic reactions to anesthetic agents, renal, hepatic, and seizure history, or was pre-medicated. Patients were administered propofol (group PF) or midazolam with thiopental (group TH). Data including patient history, physiologic parameters, duration, recovery, discharge time, and adverse events were recorded. Data was statistically analysed using Chi Square and Student T-test. &lt;strong&gt;Results: &lt;/strong&gt;A total of 34 patients were included in this study, 18 in PF and 16 TH. Sedation onset, recovery time, and mean discharge was significantly shorter in PF versus TH (6 vs 10 mins (p &amp;lt;0.0001); 8 vs 13 mins (p &amp;lt;0.0001), and 69 vs 89 mins (p &amp;lt;0.0001)). No significant differences in duration and physiologic parameters between both groups were found. No adverse events occurred in both groups. 6.25% of patients in group PF and 33.33% in group TH had inadequate sedation. &lt;strong&gt;Conclusion: &lt;/strong&gt;This study found PF has faster sedation onset and recovery time in comparison to TH for children undergoing MRI with no significant differences in physiologic parameters and adverse events. Further studies conducted on a larger population investigating efficacy and adverse events of alternative sedatives is recommended.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">289</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Erwin Mulyawan&lt;sup&gt;1*&lt;/sup&gt;, Clarissa Jasmine Aurelia&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology and Intensive Care, Faculty of Medicine, Pelita Harapan University, Tangerang, Banten, 15810, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Pelita Harapan University, Tangerang, Banten, 15810, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ashwani Kumar</style></author><author><style face="normal" font="default" size="100%">Prikshat Kumar Angra</style></author><author><style face="normal" font="default" size="100%">Suresh Chandra Akula</style></author><author><style face="normal" font="default" size="100%">Pritpal Singh</style></author><author><style face="normal" font="default" size="100%">Anuj Sharma</style></author><author><style face="normal" font="default" size="100%">Anup Sharma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy of Standardized Withania Somnifera as Neuro Agent in Tension-Type Headache: A Comparative Trial of Data in Transit</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biomarker Integrity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical Standardization</style></keyword><keyword><style  face="normal" font="default" size="100%">Sustainable Research Framework</style></keyword><keyword><style  face="normal" font="default" size="100%">Tension-Type Headache</style></keyword><keyword><style  face="normal" font="default" size="100%">Withania somnifera</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">378-385</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; To evaluate the role of withania somnifera as a neuro-psychiatric agent in the treatment of Tension-Type Headache (TTH), there is a need to substantiate the therapy using solid therapeutic evidence. Although using traditional medicine has a great potential, it is difficult to demonstrate the efficacy of a particular phytochemical composition regarding the frequency of and physiological stress markers of the chronic Tension-Type Headache in standardized research. &lt;strong&gt;Objective: &lt;/strong&gt;The purpose of the study is to assess the therapeutic efficacy of a standardized Withania somnifera extract in reducing the frequency of and physiological stress markers of the chronic Tension-Type Headache. Methods: We used the study as a double-blind and randomized controlled trial (RCT). The subjects were randomly selected to be given a standardized extract of the root of W. somnifera, that has been titrated to contain 5 percent withanolides, or a placebo dose of 60 days. The paper ensured a rigorous &quot;molecular chain of custody&quot; with a batch of withanolides linked in clinical outcome reported where the mean frequency of headaches in the treatment group reduced by 42% (p [Less than] 0.005). &lt;strong&gt;Results:&lt;/strong&gt; Clinical outcome showed that there was a significant decline in the frequency of headaches in the treatment group by 42% (p [Less than] 0.005). Moreover, the Ashwagandha group was showing a significant drop in salivary cortisol levels, which means that there was a decrease in the level of physiological stress response to chronic TTH. &lt;strong&gt;Conclusion:&lt;/strong&gt; Standardized natural products should be integrated into clinical trials as it is the most beneficial to the development of sustainable pharmacognosy. This experiment can offer an unambiguous evidence base, a clear and reproducible basis of evidence regarding the use of Ashwagandha in the current neurological practice by showing the clear efficacy in reducing the frequency of Tension-Type Headaches and biological stress markers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">378</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ashwani Kumar&lt;sup&gt;2*&lt;/sup&gt;, Prikshat Kumar Angra&lt;sup&gt;2&lt;/sup&gt;, Suresh Chandra Akula&lt;sup&gt;1&lt;/sup&gt;, Pritpal Singh&lt;sup&gt;1&lt;/sup&gt;, Anuj Sharma&lt;sup&gt;2&lt;/sup&gt;, Anup Sharma&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Mittal School of Business, Lovely Professional University, Phagwara, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Computer Applications, Lovely Professional University, Phagwara, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Selloane G. Lehasa</style></author><author><style face="normal" font="default" size="100%">Siphamandla Q.N. Lamula</style></author><author><style face="normal" font="default" size="100%">Lisa V. Buwa-Komoreng</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnomedicinal survey, phytochemical, isolation and identification of bioactive compounds from Elephantorrhiza elephantina, Pentanisia prunelloides and Dioscorea sylvatica used in the treatment of elephantiasis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bioactive compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">elephantiasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Elephantorrhiza elephantina</style></keyword><keyword><style  face="normal" font="default" size="100%">ethnomedicinal survey</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicinal plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">662-675</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;More than 200 diseases can be transmitted to people through ingesting food contaminated with microorganisms (bacteria, viruses and parasites) or chemicals. Other pathogens for example those causing malaria, tuberculosis and leprosy, as well as parasitic worms can be as chronic infections and impaired nutrition, growth, cognitive development and fertility. &lt;strong&gt;Objective: &lt;/strong&gt;The aim of this research was to screen extracts from the three plants for phytochemicals. This includesthe isolation and identification of bioactive compounds of &lt;em&gt;Elephantorrhiza elephantina&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt;In this study, an ethnomedicinal survey, phytochemical analysis, isolation, and identification of bioactive compounds were conducted in &lt;em&gt;Elephantorrhiza elephantina&lt;/em&gt;, &lt;em&gt;Pentanisia prunelloides&lt;/em&gt; and &lt;em&gt;Dioscorea sylvatica&lt;/em&gt; plant species used in the treatment of elephantiasis in most parts of the eastern Free State using standard methods. &lt;strong&gt;Results:&lt;/strong&gt;The ethnobotanical survey documented 12 medicinal plants that are used to treat lymphatic filariasis. &lt;em&gt;Elephantorrhiza elephantina&lt;/em&gt;, &lt;em&gt;Pentanisia prunelloides&lt;/em&gt; and &lt;em&gt;Dioscorea sylvatica&lt;/em&gt; were the three most used plant species. All three plants tested positive for the presence of tannins, saponins, flavonoids, steroids, terpenoids, glycosides, anthraquinones and alkaloids. Four compounds: acetyl salicylic acid, benzoic acid, resorcinol and nonanedioic acid were identified from&lt;em&gt; E. elephantina&lt;/em&gt; rhizome. Discussion:Amongst 12 documented plant species, &lt;em&gt;E. elephantina, P. prunelloides&lt;/em&gt; and &lt;em&gt;D. sylvatica &lt;/em&gt;were the most frequently used plants and were selected for isolation and characterisation of bioactive compounds. Acetyl salicylic acid, benzoic acid, resorcinol and nonanediotic acid were isolated and identified from the methanol extract from&lt;em&gt; E. elephantina&lt;/em&gt; rhizome. &lt;strong&gt;Conclusion:&lt;/strong&gt;The presence or existence of isolated phenolic-flavonoids in&lt;em&gt; E. elephantin&lt;/em&gt; demonstrated the basis for utilising it based on the isolated compounds&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">662</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Selloane G. Lehasa&lt;sup&gt;1&lt;/sup&gt;, Siphamandla Q.N. Lamula&lt;sup&gt;2*&lt;/sup&gt;, Lisa V. Buwa-Komoreng&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Plant Sciences, University of the Free State, Qwaqwa Campus, Private Bag X13, Phuthaditjhaba, 9866, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Infectious Diseases and Medicinal Plants, Biotechnology and Biological Sciences, Faculty of Science and Agriculture, University of Fort Hare, Private Bag X1314, Alice 5700, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Honnesh NH</style></author><author><style face="normal" font="default" size="100%">Santanu Saha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antioxidant Activity and Flavonoid and Phytocompounds Content in Pongamia Pinnata Seed</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP</style></keyword><keyword><style  face="normal" font="default" size="100%">GCMS</style></keyword><keyword><style  face="normal" font="default" size="100%">Karanjin</style></keyword><keyword><style  face="normal" font="default" size="100%">Pongamia pinnata</style></keyword><keyword><style  face="normal" font="default" size="100%">PPEAF</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">6</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Pongamia pinnata is a woody shrub and tree found in entire India mainly in dry areas. The seeds of P. pinnata are collected and traditionally oil is extracted and used to kill helminthes. The plant is a remedy for skin diseases, wound, rheumatism &amp;amp; ulcers and also as biofuel, green manure and fodder. This study is an attempt to know antioxidant activity of particular fraction which is having antifungal activity and flavonoid and fatty acids content which is responsible for the same. &lt;strong&gt;Materials and methods:&lt;/strong&gt; In this investigation, an effort was made to know the antioxidant activity of PPEAF by DPPH assay, FRAP assay and H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; assay methods and Optimization of mobile phase by TLC method and supporting major flavonoid content quantification by HPTLC method &lt;strong&gt;Results:&lt;/strong&gt; The result shown the ethyl acetate fraction has significant antioxidant activity of IC&lt;sub&gt;50&lt;/sub&gt; value of&lt;strong&gt; 212.09&lt;/strong&gt; (DPPH assay), &lt;strong&gt;235.87&lt;/strong&gt; (FRAP assay) and &lt;strong&gt;268.62&lt;/strong&gt; (H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; assay). The TLC method optimum mobile phase was found to be Toluene: ethyl acetate (7:3). The standard flavonoids used are Karanjin, Gallic acid and Quercetin. &lt;strong&gt;Conclusion:&lt;/strong&gt; The HPTLC method results shown PPEAF was found to contain 1.465% Karanjin. GCMS result shown the PPEAF contain 13 phytocompounds in which Octadec-9-enoic acid at retention time 22.356 was found to be abundant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Honnesh NH&lt;sup&gt;1&lt;/sup&gt;, Santanu Saha&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Nitte College of Pharmaceutical Sciences, 6429, NITTE Campus, Govindapura, Gollahalli, Yelahanka, Bangalore - 560 064, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Panner, Deralakatte, Mangaluru-575018, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lailatul Fadliyah</style></author><author><style face="normal" font="default" size="100%">Hendy Hendarto</style></author><author><style face="normal" font="default" size="100%">Lestari Sudaryanti</style></author><author><style face="normal" font="default" size="100%">Imam Susilo</style></author><author><style face="normal" font="default" size="100%">Anwar Ma’ruf</style></author><author><style face="normal" font="default" size="100%">Emuliana Sulpat</style></author><author><style face="normal" font="default" size="100%">Endah Sri Wijayanti</style></author><author><style face="normal" font="default" size="100%">Maya Septriana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect Ethanol Extract of Phyllanthus niruri l on Malondialdehyde (MDA) Expression and Extracellular Signal- Regulated Protein Kinase-1 (ERK-1) on Vaginal Epithelial Cell Thickness in Menopausal Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ERK-1</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">Menopausal Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri l</style></keyword><keyword><style  face="normal" font="default" size="100%">Vaginal epithelium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1305-1310</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Menopause is the condition of the ovaries stops produce estrogen so that resulting in vaginal bleeding atrophy that is become dry cause pain moment relate sexual so that lower quality life. The ROS pathway with MAPK regulates proliferation, differentiation, motility, and survival cell life. Research purposes is know influence giving extract Phyllanthus niruri l against Malondialdehyde (MDA) expression and Extracellular Signal-Regulated Protein Kinase-1 (ERK-1) expression against thickness cell vaginal epithelium of menopausal model mice. Material from Phillantus niruri l processed become extract. Treatment animal try mice (mus muscullus) first acclimatized during one next week done ovariectomy of both ovaries, after two weeks checked vaginal examination to be sure phase diestrus (menopause). Stage treatment given extract for 21 days with dose different 14 mg, 28 mg and 56 mg/20gBW/ day. &lt;strong&gt;Methods: &lt;/strong&gt;True Experimental research method with Post Test only with control group design. Data analysis used one way ANOVA. &lt;strong&gt;Results: &lt;/strong&gt;The research group that produced the highest average expression of Malondialdehyde (MDA) was the control group. The highest expression of Extracellular Signal-Regulated Protein Kinase-1 (ERK-1) was in the P3 treatment group (dose 56 mg/20gBW/day). The results of statistical analysis showed that there was a significant effect of Phyllanthus niruri l extract on decreasing MDA expression with a sig value of 0.000 &amp;lt; p = 21 0.001 and increasing ERK-1 with a sig value of 0.000 &amp;lt; 0.001, but there was no effect on increasing the thickness of the vaginal wall epithelial cells in menopausal model mice. with a sig value of 0.220 &amp;gt; 0.05. &lt;strong&gt;Conclusion: &lt;/strong&gt;The three doses of phillantus niruri decreased MDA and increased ERK-1. The Folin-Ciocalteau.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1305</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lailatul Fadliyah&lt;sup&gt;1,5&lt;/sup&gt;, Hendy Hendarto&lt;sup&gt;2*&lt;/sup&gt;, Lestari Sudaryanti&lt;sup&gt;3&lt;/sup&gt;, Imam Susilo&lt;sup&gt;4&lt;/sup&gt;, Anwar Ma’ruf&lt;sup&gt;5&lt;/sup&gt;, Emuliana Sulpat&lt;sup&gt;5&lt;/sup&gt;, Endah Sri Wijayanti&lt;sup&gt;5&lt;/sup&gt;, Maya Septriana&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Obstetric Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Midwifery Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Vocational Studies, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Jiang Xi University of Traditional Chinese Medicine, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Novi Fajar Utami</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Hayun Hayun</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Syamsu Nur</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Bacterial Enzymes on Reducing Chlorogenic Acid Levels in Cascara Robusta Coffee (Coffea canephora L.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bacillus subtilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cascara</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorogenic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">332-335</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Coffee skin by-products, namely cascara, have several benefits, namely can ward off free radicals, with the ability of cascara to ward off free radicals so that cascara can potentially prevent the emergence of cancer cells. Cascara contains active compounds caffeine 1.3%, chlorogenic acid 2.6%, and caffeic acid 1.6%. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to determine chlorogenic acid levels in decaffeinated robusta coffee (Coffea canephora L.) and see the influence of Bacillus subtilis bacteria on reducing chlorogenic acid levels. &lt;strong&gt;Methods:&lt;/strong&gt; The experiment was conducted from June to August 2022 in the Pharmacy Laboratory, Faculty of Mathematics and Natural Sciences, Universitas Pakuan, Indonesia. Cascara robusta coffee is fermented using Bacillus subtilis with a concentration of 6% and a time of 24 hours. After fermentation, the extraction is carried out using the UAE (Ultrasonic Assisted Extraction) method. The chlorogenic acid levels and zero control of cascara robusta coffee obtained were then analyzed using Statistical Package for the Social Science (SPSS) with the Paired sample t-test method previously carried out with normality test and homogeneity test first. &lt;strong&gt;Results:&lt;/strong&gt; The study found chlorogenic acid levels produced from cascara robusta coffee that had undergone decaffeination. Quantitative analysis of chlorogenic acid levels in cascara robusta coffee was carried out using HPLC mobile phase methanolwater (adjust Orthoposphat pH 2.4), flow rate 0.7 mL/minute, with an isocratic system of an average of 14.8597%. &lt;strong&gt;Conclusion:&lt;/strong&gt; Chlorogenic acid levels in robusta coffee cascara decaffeinated by microbial enzymes can affect chlorogenic acid levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">332</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Novi Fajar Utami&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1*&lt;/sup&gt;, Hayun Hayun&lt;sup&gt;3&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;4,5,6&lt;/sup&gt;, Syamsu Nur&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Phytochemistry and Pharmacognosy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Math and Science, Universitas Pakuan, Jl. Raya Pakuan 1 Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Pharmaceutical Chemistry, Almarisah Madani University, Makassar, South Sulawesi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Faiz Muhammad Ammar</style></author><author><style face="normal" font="default" size="100%">Christrijogo Sumartono Waloejo</style></author><author><style face="normal" font="default" size="100%">Herdiani Sulistyo Putri</style></author><author><style face="normal" font="default" size="100%">Kohar Hari Santoso</style></author><author><style face="normal" font="default" size="100%">Prananda Surya Airlangga</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Cacao Bean Extract as a Paracetamol Adjuvant on Pain Scale and Tumor Necrosis Factor-Alpha in Neuropathic Pain: An Animal Model Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cacao</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuropathic pain</style></keyword><keyword><style  face="normal" font="default" size="100%">pain scale</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1336-1341</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; One treatment for neuropathic pain is paracetamol. Meanwhile, cacao bean extract is a traditional remedy developed for pain management. &lt;strong&gt;Objective:&lt;/strong&gt; Analyzing effect of combining cacao bean extract and paracetamol on pain scale and tumor necrosis factor-alpha (TNF-α) in neuropathic pain. &lt;strong&gt;Methods:&lt;/strong&gt; Subjects were randomized post-test only control group design from 28 mice (Mus musculus) to 4 groups: G&lt;sub&gt;0&lt;/sub&gt; (control), G&lt;sub&gt;1&lt;/sub&gt; (paracetamol only), G&lt;sub&gt;2&lt;/sub&gt; (cacao + paracetamol), and G&lt;sub&gt;3&lt;/sub&gt; (cacao + ½ doses paracetamol). The subject assessed pain scale using von Frey test and TNF-α. The statistical analysis includes paired t-tests, Wilcoxon, one-way ANOVA, Kruskal Wallis, and Pearson correlation tests with p &amp;lt;0.05. &lt;strong&gt;Results:&lt;/strong&gt; The combination of cacao bean extract and paracetamol resulted in a pain scale of 2.57 ± 1.10 gf, with significant differences observed among the four groups (p &amp;lt;0.001). Significant differences in pain scale scores were found in four groups (p &amp;lt;0.001), including G&lt;sub&gt;0&lt;/sub&gt; (p = 0.006), G&lt;sub&gt;1&lt;/sub&gt; (p &amp;lt;0.001), G&lt;sub&gt;2&lt;/sub&gt; (p &amp;lt;0.001), and G&lt;sub&gt;3&lt;/sub&gt; (p &amp;lt;0.001). After treatment, the average TNF-α levels was 86.96 ± 23.73 ng/mL, with significant differences observed among the four groups (p &amp;lt;0.001). There was a strong correlation between the pain scale and TNF-α levels (p &amp;lt;0.001). &lt;strong&gt;Conclusion: &lt;/strong&gt;In an animal model of neuropathic pain, using cacao bean extract as a paracetamol adjuvant significantly reduces pain scale (as measured by the von Frey test) and TNF-α levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1336</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Faiz Muhammad Ammar&lt;sup&gt;1,2&lt;/sup&gt;, Christrijogo Sumartono Waloejo&lt;sup&gt;1,2&lt;/sup&gt;, Herdiani Sulistyo Putri&lt;sup&gt;1,2*&lt;/sup&gt;, Kohar Hari Santoso&lt;sup&gt;1,2&lt;/sup&gt;, Prananda Surya Airlangga&lt;sup&gt;1,2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology and Reanimation, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anesthesiology and Reanimation, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mila Islamia</style></author><author><style face="normal" font="default" size="100%">Abul Fauzi</style></author><author><style face="normal" font="default" size="100%">Eka Prasetiawaty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Conservative Vs Surgical Therapy on the Quality of Life of Patients with Maxillofacial Trauma: A Systematic Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">conservative treatment</style></keyword><keyword><style  face="normal" font="default" size="100%">Maxillofacial trauma</style></keyword><keyword><style  face="normal" font="default" size="100%">MMF</style></keyword><keyword><style  face="normal" font="default" size="100%">ORIF</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality of life</style></keyword><keyword><style  face="normal" font="default" size="100%">surgical treatment</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1218-1222</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Selecting the best treatment strategy for maxillofacial trauma patients has grown challenging as a result of the continuous discussion on how different therapies affect these patients' quality of life. The purpose of this research is to methodically evaluate how conservative care and surgical care affect patients with maxillofacial trauma's quality of life.&lt;strong&gt; Methods:&lt;/strong&gt; A systematic search was undertaken using PubMed, Cochrane Library, and Wiley Online Library to locate the most recent 20 years of research comparing the effects of various treatments on the quality of life of patients with maxillofacial injuries. We also looked through relevant researchers' references to find further studies. Articles were selected by applying a search strategy based on the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA) guidelines.&lt;strong&gt; Results: &lt;/strong&gt;This systematic review comprised 9 comparison studies with 944 individuals in total. The findings show that patients with maxillofacial trauma had lower quality of life initially, but that after receiving therapy, their quality of life increased to varying degrees, depending on the type of treatment. &lt;strong&gt;Conclusion:&lt;/strong&gt; The majority of research revealed that patients who received MMF or ORIF did not significantly vary in terms of quality of life; however, those who were treated conservatively reported a notable improvement when compared to those who received surgical treatment (MMF/ORIF).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1218</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mila Islamia&lt;sup&gt;1&lt;/sup&gt;, Abul Fauzi&lt;sup&gt;2*&lt;/sup&gt;, Eka Prasetiawaty&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Lecturer at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Resident at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marselina Sattu</style></author><author><style face="normal" font="default" size="100%">Aminuddin Syam</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Wahiddudin</style></author><author><style face="normal" font="default" size="100%">Anwar Malongi</style></author><author><style face="normal" font="default" size="100%">Stang</style></author><author><style face="normal" font="default" size="100%">Andi Dirpan</style></author><author><style face="normal" font="default" size="100%">Balqis</style></author><author><style face="normal" font="default" size="100%">Yustianty Monoarfa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Consumption Rice Analogue of Banggai Yam (Dioscorea Alata) on Blood Sugar Levels of Pre-Diabetic Patients in the District of Banggai Archipelago</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analog Rice</style></keyword><keyword><style  face="normal" font="default" size="100%">Banggai Yams</style></keyword><keyword><style  face="normal" font="default" size="100%">Blood Sugar.</style></keyword><keyword><style  face="normal" font="default" size="100%">Prediabetes Mellitus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">845-850</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Rice analogue of banggai yam (dioscorea alata) is made with the formula of banggai yam flour, mocaf flour and cornstarch in a ratio of 55:30:15. Furthermore, Banggai Yam's Analog rice (Dioscorea Alata) was given to respondents with prediabetes. The purpose of this study was to determine the effect of consumption of rice analogues of yam banggai on glucose levels of prediabetics. The research location is in Banggai Islands Regency. The number of respondents was 120 people and the intervention time was 2 weeks. The results showed that fasting blood sugar levels on pre and day 7 in both groups had differences or there was a decrease in fasting blood sugar levels with p values of &amp;lt;0.001 each. The greatest change was shown in the intervention/rice analog group with a difference of 24.55. While in the control group only amounted to 8,483. Reduction in Fasting Blood Sugar Levels on pre and day 14 p values of &amp;lt;0.001 each. The greatest change was shown in the intervention/rice analog group with a difference of 29.817. While the decrease in fasting blood sugar levels in the control group was 17,167. Comparison of day 7 and day 14, the two groups had differences or there was a decrease in fasting blood sugar levels with a p value of &amp;lt;0.001 each. Greater changes were shown in the control/brown rice group with a difference of 8.683. While the decrease in fasting blood sugar levels in the intervention group was 5,267. Thus, rice analogue of Banggai yam (dioscorea alata) as local food has a significant influence on reducing blood sugar levels of prediabetes mellitus sufferers in Banggai Islands district. The use of rice analogues of Banggai Yams (Dioscorea Alata) can be developed as functional foods.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">845</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Marselina Sattu&lt;sup&gt;1,4&lt;/sup&gt;, Aminuddin Syam&lt;sup&gt;2*&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;2&lt;/sup&gt;, Wahiddudin&lt;sup&gt;3&lt;/sup&gt;, Anwar Malongi&lt;sup&gt;2&lt;/sup&gt;, Stang&lt;sup&gt;2&lt;/sup&gt;, Andi Dirpan&lt;sup&gt;5&lt;/sup&gt;, Balqis&lt;sup&gt;5&lt;/sup&gt;, Yustianty Monoarfa&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program Study, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Agricultural Technologi, Hasanuddin University Makassar 90245, INDONESIA.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Public Health, Tompotika University, Banggai, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Agriculture, Tompotika University, Banggai, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manggiasih Dwiayu Larasati</style></author><author><style face="normal" font="default" size="100%">Silvia W. Lestari</style></author><author><style face="normal" font="default" size="100%">Mulyoto Pangestu</style></author><author><style face="normal" font="default" size="100%">Andon Hestiantoro</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Cryopreservation on the Sperm Ultrastructure of Mus Musculus Albinus Strain DDY: Comparison of Nakagata vs Modified vs Kitazato Cryoprotectants</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">cryopreservation</style></keyword><keyword><style  face="normal" font="default" size="100%">glycerol</style></keyword><keyword><style  face="normal" font="default" size="100%">mice sperm</style></keyword><keyword><style  face="normal" font="default" size="100%">raffinose</style></keyword><keyword><style  face="normal" font="default" size="100%">Scanning electron microscope</style></keyword><keyword><style  face="normal" font="default" size="100%">Trehalose</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">563-569</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sperm morphology analysis is very necessary to understand male fertility and the etiology of infertility. Currently, scanning electron microscopy (SEM) has been widely used to determine surface topology. In this study, we will compare the effects of spermatozoa cryopreservation using three different types of cryoprotectants, namely Nakagata, modification and Kitazato. The cryoprotectant compositions used are Nakagata (raffinose and skim milk), modified (glycerol and raffinose) and Kitazato (glycerol and trehalose). &lt;strong&gt;Methods:&lt;/strong&gt; SEM analysis was carried out on 8 sperm samples before cryopreservation and after the freeze-thaw process. &lt;strong&gt;Results:&lt;/strong&gt; The results obtain showed that cryoprotectant modification was able to protect spermatozoa morphology better than Nakagata and Kitazato. Analysis revealed damage to plasma membrane, acrosome and loss of mitochondria in all treatment groups compared to fresh sperm. SEM showed obvious signs of post-thaw damage such as missing plasma membranes, sperm showing damaged acrosomes and mitochondria in the middle showing structural disorganization. &lt;strong&gt;Conclusion: &lt;/strong&gt;SEM revealed that cryopreservation caused ultrastructural damage to mice sperm due to freezing and thawing. These details provide valuable data for further research to minimize the damage caused by cryopreservation to mice sperm. Apart from that, further examination using TEM is recommended to obtain a more comprehensive picture.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">563</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Manggiasih Dwiayu Larasati&lt;sup&gt;1&lt;/sup&gt;, Silvia W. Lestari&lt;sup&gt;2&lt;/sup&gt;,* Mulyoto Pangestu&lt;sup&gt;3&lt;/sup&gt;, Andon Hestiantoro&lt;sup&gt;4&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;5-7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Education Program in Reproduction and Development, Department of Obstetrics and Gynecology, School of Clinical Sciences, Monash University, Victoria, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Drug Development Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Human Cancer Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sheinni Paradise</style></author><author><style face="normal" font="default" size="100%">M. Alimin Maidin</style></author><author><style face="normal" font="default" size="100%">Amran Razak</style></author><author><style face="normal" font="default" size="100%">Abdul Rahman KadirHegazy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Diet, Medication, Physical Activity on Glycemic Control of Type-2 Diabetes Mellitus Patients in Makassar City</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1110-1113</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The prevalence of diabetes mellitus continues to increase every year with various complications. This is caused by an unhealthy lifestyle. The complex management of type 2 diabetes mellitus triggers problems that cause therapeutic goals not to be achieved. The risk of complications is higher due to lack of attention to lifestyle including diet. A good diet, medication and physical activity are considered capable of improving blood sugar control so that the quality of life of people with diabetes mellitus becomes better. Objective: to analyze the effect of diet, medication, physical activity on glycemic control of patients with type 2 diabetes mellitus. Methods: the study was conducted in December 2023-February 2024 at Kassi-Kassi Health Center and Kalukubodoa Health Center, Makassar City, South Sulawesi. The sample size was type 2 diabetes mellitus patients in Kassi-Kassi Health Center as many as 184 people and Kalukubodoa Health Center as many as 168 people. The research group consisted of 2 groups, namely at Puskesmas Kassi- Kassi and Puskesmas Kalukubodoa with a combination intervention of food menu modules for diabetic patients and leaflets and Puskesmas Kassi-Kassi with food menu modules for diabetic patients. Both research groups were intervened for 3 (three) months with the assistance of doctors and nutritionists. There are two stages in this study, namely stage 1 making a prolanis intervention model with quantitative methods followed by stage 2, namely the intervention of food menu modules for diabetic patients and with quasi-experimental methods with a non-randomized pretest postest design. Results: In the aspects of diet, medication, physical activity there is a significant increase in Kassi-Kassi Health Center and Kalukubodoa Health Center (p=0.00) on glycemic control of type-2 diabetes mellitus patients. Conclusion: The results of the trial of the food menu module for patients with type 2 diabetes mellitus showed a value of 80%, meaning that the module was feasible to use based on the assessment of the material expert. Diet, medication, physical activity have a statistical effect and there is a difference in the mean value of glycemic control of type-2 diabetes mellitus patients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1110</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sheinni Paradise*, M. Alimin Maidin, Amran Razak, Abdul Rahman Kadir&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Hasanuddin University, Makassar City, Province South Sulawesi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Darmin Dina</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Hasnawati Amqam</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Wahiduddin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Apik Indarty Moedjiono</style></author><author><style face="normal" font="default" size="100%">Anang S. Otoluwa</style></author><author><style face="normal" font="default" size="100%">Yulianah Sulaiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Giving Iodized Salt and Multi Micro Nutrients to Pregnant Women on the Nutritional Status of Pregnant Women in Majene Regency</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Pregnant women; Iodine Salt; Multi Micro Nutrient Supplement; Nutritional status.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">779-784</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Background:&lt;/strong&gt; Maternal nutritional needs during pregnancy increase due to physiological, metabolic and anatomical changes. If the intake is insufficient, there will be deficiencies in both macro and micro nutrients. Multimicronutrient deficiency will affect the growth and anemia status of pregnant women. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to determine the effect of giving iodized salt and Multi Micronutrient Supplements to pregnant women on hemoglobin levels, body weight, iodine levels in urine and pregnancy outcomes. &lt;strong&gt;Method:&lt;/strong&gt; This research is an analytical research using an experimental design that controls several nonexperimental variables and there is a control group as a comparison group to understand the effect of treatment. Determining the sample in this study used a random experimental method where 200 pregnant women were used as the research sample. The results showed that there was a significant change or increase in Hb levels (p=0.006; &amp;lt;0.000; &amp;lt;0.000), body weight (p=0.001; &amp;lt;0.000; &amp;lt;0.000), lila (&amp;lt;0.0015; &amp;lt;0.000; &amp;lt;0.000 ), Iodine levels (&amp;lt;0.000; &amp;lt;0.000; &amp;lt;0.000), between the group given iodized salt and MMS and the group given MMS. In this study, in the group of pregnant women who received iodized salt and MMS intervention, on average there was an increase or change in HB levels, iodine levels, mother's weight, baby's weight and abdominal length and circumference compared to those who received MMS. for pregnant women is to regularly maintain nutritional intake during pregnancy, especially consuming iodized salt and MMS which is beneficial for the health of pregnant women and the baby they are carrying.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">779</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Darmin Dina&lt;sup&gt;1,2*&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;3&lt;/sup&gt;, Veni Hadju&lt;sup&gt;4&lt;/sup&gt;, Hasnawati Amqam&lt;sup&gt;5&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;6&lt;/sup&gt;, Wahiduddin&lt;sup&gt;7&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;8&lt;/sup&gt;, Apik Indarty Moedjiono&lt;sup&gt;9&lt;/sup&gt;, Anang S. Otoluwa&lt;sup&gt;10&lt;/sup&gt;, Yulianah Sulaiman&lt;sup&gt;11&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Hasanuddin University FKM Nutrition Science Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;D III Midwifery Study STIKES Bina Bangsa Majene Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Hasanuddin University FKM Nutrition Science Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Hasanuddin University FKM Nutrition Science Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Hasanuddin University FKM Public Health Science Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Hasanuddin University FKM Epiodiomology Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Hasanuddin University FKM Epidiomology Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Hasanuddin University&amp;nbsp;FKM Environmental Health Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Hasanuddin University FKM Bioastatistics Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;UNTIKA Luwuk Faculty of Public Health, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;D III Midwifery Study STIKES Bina Bangsa Majene Program, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zuraida</style></author><author><style face="normal" font="default" size="100%">Silvia Werdhy Lestari</style></author><author><style face="normal" font="default" size="100%">Mulyoto Pangestu</style></author><author><style face="normal" font="default" size="100%">Andon Hestiantoro</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Glutathione Supplementation in Cryoprotectant Modification on Tyrosine Phosphorylation, Acrosin Expression and Acrosome Reaction of Post-Thawing Spermatozoa Quality</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">acrosin expression</style></keyword><keyword><style  face="normal" font="default" size="100%">acrosome reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">CPA modification</style></keyword><keyword><style  face="normal" font="default" size="100%">glutathione (GSH)</style></keyword><keyword><style  face="normal" font="default" size="100%">spermatozoa cryopreservation</style></keyword><keyword><style  face="normal" font="default" size="100%">tyrosine phosphorylation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">554-562</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Tyrosine phosphorylation, acrosin, and acrosome reaction play an important role in fertilisation. However, cryopreservation causes changes in tyrosine phosphorylation, acrosin expression, and acrosome reaction which affect the quality of spermatozoa. Cryoprotectant media added with antioxidants is needed to protect Spermatozoa from the effects of cryopreservation so that the quality of spermatozoa can be maintained. &lt;strong&gt;Objectives:&lt;/strong&gt; This research examined the effect of glutathione (GSH) supplementation in cryopreservation media on tyrosine phosphorylation, acrosin expression, and acrosome reaction. In this research, pure modified Cryoprotectant (CPA) was compared with CPA supplemented with GSH in three different concentrations. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The research sample was male mus musculus albinus strain Deutchland Denken Yoken (DDY). Mice spermatozoa was cryopreserved and several parameters were measured including tyrosine phosphorylation, acrosin expression, and acrosome reaction. &lt;strong&gt;Results:&lt;/strong&gt; The addition of GSH to the modified CPA increased tyrosine phosphorylation, acrosin expression, and acrosome reaction (maintaining acrosome integrity). The group with 1.00 mM GSH obtained the highest results among the other groups. Significant increases were found in tyrosine phosphorylation, acrosin expression, and acrosome reaction after the addition of 1.00 mM GSH. &lt;strong&gt;Conclusion:&lt;/strong&gt; Glutathione supplementation in modified CPA can increase tyrosine phosphorylation, acrosin expression, and acrosome reaction of frozen-thawed spermatozoa. Treatment using GSH at a dose of 1.00 mM is the most effective and modification of CPA with the addition of glutathione can improve the tyrosine phosphorylation, acrosin expression and acrosome reaction in cryopreserved spermatozoa.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">554</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Zuraida&lt;sup&gt;1,2&lt;/sup&gt;, Silvia Werdhy Lestari&lt;sup&gt;3&lt;/sup&gt;,*, Mulyoto Pangestu&lt;sup&gt;4&lt;/sup&gt;, Andon Hestiantoro&lt;sup&gt;5&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;6-8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia; Jl. Salemba Raya No. 6, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Midwifery, Faculty of Health, Universitas Fort de Kock Bukittinggi, Jl. Soekarno Hatta No. 11, Bukittinggi, Sumbar 26117 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Education Program in Reproduction and Development, Department of Obstetrics and Gynecology, School of Clinical Sciences, Monash University, Victoria, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Drug Development Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Human Cancer Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Erwin Mulyawan</style></author><author><style face="normal" font="default" size="100%">Clarissa Jasmine Aurelia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Glycopyrrolate to Support Fentanyl on Reducing Airway Irritation during Inhalation Induction with Desflurane and Nitrous Oxide in Adult Patients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Airway Irritation</style></keyword><keyword><style  face="normal" font="default" size="100%">Desflurane</style></keyword><keyword><style  face="normal" font="default" size="100%">Fentanyl</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycopyrrolate</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">42-45</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Inhalational induction of anesthesia is occasionally used in adults. Desflurane is not used for the induction of anesthesia despite its favorable pharmacokinetic characteristics as it causes airway irritation. This study aims to identify a reduction of airway irritation with pretreatment using fentanyl and glycopyrrolate. &lt;strong&gt;Methods: &lt;/strong&gt;A total of 80 adults were randomized into two groups to receive fentanyl and glycopyrrolate (FG group) or fentanyl only (FS group) prior to desflurane administration. Time between desflurane administration and loss of consciousness was recorded as well as expired desflurane concentration. Signs of airway irritation including coughing, apnea, laryngospasm, and excitatory movements at time of induction was also recorded. Unpaired t test, Fisher’s Exact test, and Chi-square test were used to analyze parametric data and all non-parametric data was analyzed using the Mann– Whitney test.&lt;strong&gt; Results: &lt;/strong&gt;This study found time to loss of consciousness was 4 minutes. Incidence of airway irritation in Group FS vs FG including cough, apnea, excitatory movements, and laryngospasm was (20% vs 2.5%), (0% vs 0%), (5% vs 5%), and (7.5% vs 0%) respectively. Total airway irritation was 32.5% in FS compared to 7.5% in FG, with P value 0.0103.&lt;strong&gt; Conclusion:&lt;/strong&gt; Use of fentanyl and glycopyrrolate decreases airway irritation incidence caused by desflurane in comparison to use of fentanyl alone. This opens the possibility to commonly use desflurane as inhalation induction of anesthesia as its favorable pharmacokinetics may be utilized whilst limiting the adverse effects it causes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">42</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Erwin Mulyawan&lt;sup&gt;1&lt;/sup&gt;*, Clarissa Jasmine Aurelia&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology, Faculty of Medicine, Pelita Harapan University, Tangerang, Banten, 15810, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Pelita Harapan University, Tangerang, Banten, 15810, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sofia Wardhani</style></author><author><style face="normal" font="default" size="100%">Aryati Aryati</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of HBOT on SIRT-1 and SYNDECAN-1 as Therapeutic Targets for Endothelial Dysfunction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Endothelial dysfunction</style></keyword><keyword><style  face="normal" font="default" size="100%">HBO2</style></keyword><keyword><style  face="normal" font="default" size="100%">Sirt-1</style></keyword><keyword><style  face="normal" font="default" size="100%">Syndecan-1</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1090-1095</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The effect of HBO2 alone on Sirt-1 and Syndecan-1 is unknown, even though both molecules are involved in preventing endothelial dysfunction. This study aims to determine the effect of HBO&lt;sub&gt;2&lt;/sub&gt; on Sirt-1 and Syndecan-1 as therapeutic targets for endothelial dysfunction. &lt;strong&gt;Method:&lt;/strong&gt; This study employed a true experimental post-test design. Twenty male Sprague Dawley rats aged 12-14 weeks were divided into two groups. Diving was carried out in an animal hyperbaric chamber with a dose of 2.4 ATA for 60 minutes. All data were collected 18 hours after diving. &lt;strong&gt;Results:&lt;/strong&gt; Our study revealed that the administration of HBO caused an increase in serum MDA and endothelial NF-kB levels (p = 0.007; p = 0.001, respectively) without an increase in any inflammatory markers, specifically IL-1 and VCAM-1 levels (p = 0.707; p = 0.168, respectively). HBO&lt;sub&gt;2 &lt;/sub&gt;decreased Syndecan-1, a marker of endothelial injury (p = 0.026), but did not affect endothelial eNOS and Sirt-1. &lt;strong&gt;Conclusion: &lt;/strong&gt;HBO&lt;sub&gt;2&lt;/sub&gt; did not cause endothelial injury and inflammation, but the dose used was not enough to increase Sirt-1 levels. Additional research is needed to determine a hormesis dose that can increase Sirt-1 levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1090</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sofia Wardhani&lt;sup&gt;1&lt;/sup&gt;, Aryati Aryati&lt;sup&gt;2*&lt;/sup&gt;, Bambang Purwanto&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mia Ratwita Andarsini</style></author><author><style face="normal" font="default" size="100%">Andy Darma</style></author><author><style face="normal" font="default" size="100%">Alpha Fardah Athiyyah</style></author><author><style face="normal" font="default" size="100%">Khadijah Rizky Sumitro</style></author><author><style face="normal" font="default" size="100%">Reza Gunadi Ranuh</style></author><author><style face="normal" font="default" size="100%">Fauziah Pratiwi</style></author><author><style face="normal" font="default" size="100%">Wibi Riawan</style></author><author><style face="normal" font="default" size="100%">Widjiati Widjiati</style></author><author><style face="normal" font="default" size="100%">Ingrid S Surono</style></author><author><style face="normal" font="default" size="100%">Subijanto Marto Sudarmo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Lactiplantibacillus plantarum IS-10506 on Accelerating Repair of Ketorolac-Induced Gastric Ulcers in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">181-185</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;A gastric ulcer arises due to an imbalance between the stomach's aggressive and defensive factors, one of which can be induced by ketorolac. The gastric mucosa serves as a protective layer against gastric damage. Probiotics may enhance mucosal secretion, reinforcing their barrier function. This study evaluated the effect of Lactiplantibacillus plantarum IS-10506 on repairing gastric mucosal injury expressed by Mucin 5AC (MUC5AC) induction from ketorolac in rodent model. In the experiment, 48 male Wistar rats were randomly assigned and segregated into four groups: the control group (K1), the group with ketorolac administration (K2), the group given L. plantarum IS-10506 after ketorolac administration (K3), and the group given L. plantarum IS-10506 before and after ketorolac administration (K4). Gastric tissue was examined for cells producing MUC5AC via immunohistochemistry. MUC5AC differences between groups were compared using Kruskal–Wallis and Mann–Whitney U tests. Significant differences were observed between each group on Days 5, 7, and 10 of necropsy (p=0.043; p=0.030; p=0.022). The ketorolac group (K2) consistently exhibited the lowest values during all examination days. Group K4 manifested a higher expression of MUC5AC relative to group K3. However, group K3 demonstrated a significantly increased from Day 1 to 10 of necropsy (p=0.030). Administering probiotic L. plantarum IS-10506 prior to ketorolac proved beneficial by significantly accelerate (p=0.030) the MUC5AC expression cells and gene expression.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">181</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mia Ratwita Andarsini&lt;sup&gt;1,2&lt;/sup&gt;, Andy Darma&lt;sup&gt;1,2&lt;/sup&gt;, Alpha Fardah Athiyyah&lt;sup&gt;1,2&lt;/sup&gt;, Khadijah Rizky Sumitro&lt;sup&gt;1,2&lt;/sup&gt;, Reza Gunadi Ranuh&lt;sup&gt;1,2&lt;/sup&gt;,*, Fauziah Pratiwi&lt;sup&gt;1,2&lt;/sup&gt;, Wibi Riawan&lt;sup&gt;3&lt;/sup&gt;, Widjiati Widjiati&lt;sup&gt;4&lt;/sup&gt;, Ingrid S Surono&lt;sup&gt;5&lt;/sup&gt;, and Subijanto Marto Sudarmo&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biomolecular Biochemistry, Faculty of Medicine, Brawijaya University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Veterinary Medicine, Faculty of Veterinary Medicine, Airlangga University, East Java, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Food Technology Department, Faculty of Engineering, Bina Nusantara University, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lina Fitriani</style></author><author><style face="normal" font="default" size="100%">Citrakesumasari</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Sudirman Nasir</style></author><author><style face="normal" font="default" size="100%">Apik Indarty Moedjiono</style></author><author><style face="normal" font="default" size="100%">Masyitha Muis</style></author><author><style face="normal" font="default" size="100%">Nurpudji Astuti Taslim</style></author><author><style face="normal" font="default" size="100%">Sri Sumarni</style></author><author><style face="normal" font="default" size="100%">M.Bambang Uswatul Firdaus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Moringa Oleifera Plus Royal Jelly Capsules in The Gestation Age and Placenta Weight of Newborns in Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adverse Birth Outcomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Multiple Micronutrient Supplement</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy outcomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnant women</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1177-1182</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The incidence of adverse birth outcomes (ABO) in low- and middle-income countries (LIMC) remains significantly elevated. Moringa oleifera (MO), rich nutritional profile, offers to reduce ABO. Therefore, this study aimed to evaluate the impact of MO plus royal jelly capsules on the gestational age and placental weight of newborns in Indonesia. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; A quasi-experimental design setup in the Banggai district, Central Sulawesi Province. The study used a purposive sampling of 80 pregnant women from each sub-district. Moilong District received MRJ, while South Batui District was the Multiple Micronutrient Supplement (MMS) control group. Both groups took one capsule daily for six months. Data analysis using SPSS v28 for Windows, including Chi-square/Fisher's exact test, Kolmogorov- Smirnov test, Mann-Whitney test, and ANCOVA, with a significance level of p &amp;lt; 0.05. &lt;strong&gt;Results: &lt;/strong&gt;The demographic characteristics in both groups were similar (p &amp;gt; 0.05), except for BMI (p=0.031). Pregnancy outcomes data were also identical (p &amp;gt; 0.05). The Mann-Whitney test did not show a significant difference (p = 0.696) in the gestational age of delivery between the groups. However, there was a significant difference (p &amp;lt; 0.05) in the PW variable within the MRJ group, as shown by the Mann-Whitney test. After adjusting for BMI in PW, the ANCOVA test indicated a significant difference (p = 0.001).&lt;em&gt; Conclusions: &lt;/em&gt;The study concludes that MRJ and MMS interventions are effective and safe in preventing ABO in newborns based on gestational age and placental weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1177</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lina Fitriani&lt;sup&gt;1,2*&lt;/sup&gt;, Citrakesumasari&lt;sup&gt;2&lt;/sup&gt;, Veni Hadju&lt;sup&gt;2&lt;/sup&gt;, Sudirman Nasir&lt;sup&gt;3&lt;/sup&gt;, Apik Indarty Moedjiono&lt;sup&gt;4&lt;/sup&gt;, Masyitha Muis&lt;sup&gt;5&lt;/sup&gt;, Nurpudji Astuti Taslim&lt;sup&gt;6&lt;/sup&gt;, Sri Sumarni&lt;sup&gt;7&lt;/sup&gt;, M.Bambang Uswatul Firdaus&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Health, Mega Buana University, Palopo, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Nutritional Sciences, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health Sciences, Faculty of Public Health, Universitas Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biostatistics and Demographics, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Nutrition, Faculty of Midicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Nutrition Science, Faculty of Public Health, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amani Abduljabar Altaie</style></author><author><style face="normal" font="default" size="100%">Emad Farhan Alkhalidi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Plasma Treatment on Tensile Bond Strength of (5) Yttrium Zirconia Coping Fixed on Titanium Implant Abutment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">(5)Y Zirconia. Tensile bond strength</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasma</style></keyword><keyword><style  face="normal" font="default" size="100%">Titanium abutment</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">205-210</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The goal of this research is to investigate the effect of plasma surface treatment on retentive strength (RS) between the (5)Yttrium Zirconia coping and the titanium implant abutment (Dentium system) using self-adhesive resin cement.&lt;strong&gt; Methods:&lt;/strong&gt; forty standard titanium implant abutments of 5.5 mm height and 4.5 mm in diameter were screwed with implant laboratory analogs embedded vertically in autopolymerizing acrylic resin blocks, forty Zirconia copings with a hole on the occlusal surface were fabricated using CAD/CAM system. Samples were divided into four groups (n 10 for each group); Group (1) no plasma surface treatment for implant abutment and coping (act as control). Group (2) plasma surface treatment for implant abutment only. Group (3) plasma surface treatment for coping only. Group (4)plasma surface treatment for implant abutment and coping. Coping of all groups were cemented with implant abutment by Allcem dual cure resin cement. All cemented samples were (5000) cycles of thermocycling process and then tensile bond strength evaluated by Universal testing machine, Following the tensile bond strength test, each debonded surface was examined by stereomicroscope at a 20x magnification. The one-way analysis of variance and Duncan test were used to statistically examine the experimental results. &lt;strong&gt;Results:&lt;/strong&gt; Plasma surface treatment had observed effect that increase tensile bond strength between titanium implant abutment and (5) yttrium Zirconia coping, plasma surface treatment for abutment and coping (Group 4) was the highest value of tensile strength followed by abutment plasma surface treatment (Group 2), while lowest value of tensile bond strength in control group (Group 1) and coping plasma surface treatment (Group 3). &lt;strong&gt;Conclusion: &lt;/strong&gt;Plasma surface treatment increase tensile bond strength between implant abutment and zirconia coping. Plasma surface treatment for both abutment and coping provided higher tensile bond strength. Mode of failure was adhesive failure occurs in abutment surface.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">204</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amani Abduljabar Altaie *, Emad Farhan Alkhalidi&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of conservative dentistry, College of Dentistry, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Andika Perdani Somawi</style></author><author><style face="normal" font="default" size="100%">Nancy Margarita Rehatta</style></author><author><style face="normal" font="default" size="100%">Prihatma Kriswidyatomo</style></author><author><style face="normal" font="default" size="100%">Kohar Hari Santoso</style></author><author><style face="normal" font="default" size="100%">Hamzah</style></author><author><style face="normal" font="default" size="100%">Pudji Lestari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Propofol TIVA Compared Sevoflurane Inhalation Anesthesia on Triglyceride Levels After Elective Craniotomy Surgery</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Craniotomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Sevoflurane</style></keyword><keyword><style  face="normal" font="default" size="100%">TIVA propofol</style></keyword><keyword><style  face="normal" font="default" size="100%">Triglycerides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">597-601</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Propofol TIVA has been shown to be more effective than sevoflurane in craniotomy surgery. Propofol TIVA offers the benefit of giving better brain relaxation during surgery while also being less expensive than sevoflurane. Nonetheless, it is important to highlight that propofol has side effects that should be considered. Large doses and prolonged anesthesia may result in increased triglycerides (lipids) as well as Propofol Infusion Syndrome (PRIS). As part of their investigation into the detrimental effects of propofol, researchers discovered the necessity for controls to avoid confusing the effects of the surgery itself. Therefore, sevoflurane was chosen as the control group to comprehend and analyze the effects of propofol more accurately. &lt;strong&gt;Methods: &lt;/strong&gt;A prospective observational study analysis was conducted on elective craniotomy patients at RSUD Dr. Soetomo from November to December 2023. 52 subjects were divided into two groups, namely the TIVA Propofol and Sevoflurane Inhalation groups. Each group will be examined for preoperative triglyceride levels and postoperative triglyceride levels while already in the ICU. &lt;strong&gt;Results:&lt;/strong&gt; Postoperative triglyceride levels in the Propofol TIVA group were significantly higher. In the comparison test between the two anesthesia methods on triglyceride levels, there was a significant effect in the Propofol TIVA group. In the test of the relationship between the duration of anesthesia in both groups, there was no significant relationship. In the test of the relationship between the total dose of propofol and triglyceride levels, it was found that the greater the dose of propofol used, the higher the increase in triglyceride levels. In the test of the relationship between the total amount of sevoflurane and triglyceride levels, it was found that the greater the dose of sevoflurane used, the greater the decrease in triglyceride levels, which was statistically not significant.&lt;strong&gt; Conclusion:&lt;/strong&gt; TIVA Propofol increases triglyceride levels compared to sevoflurane inhalation in patients undergoing elective craniotomies.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">597</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Andika Perdani Somawi&lt;sup&gt;1&lt;/sup&gt;*, Nancy Margarita Rehatta&lt;sup&gt;1&lt;/sup&gt;, Prihatma Kriswidyatomo&lt;sup&gt;1&lt;/sup&gt;, Kohar Hari Santoso&lt;sup&gt;1&lt;/sup&gt;, Hamzah&lt;sup&gt;1&lt;/sup&gt;, Pudji Lestari&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Departement of Anesthesiology and Reanimation, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Public Health Science Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ratnawati Ratnawati</style></author><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author><author><style face="normal" font="default" size="100%">Atina Hussaana</style></author><author><style face="normal" font="default" size="100%">Arrizki Azka Pratama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Tender Coconut Water Powder Enriched with Vitamin E in Preventing Oxidative Stress of Diabetes Male Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Tender coconut water powder; oxidative stress; Diabetes mellitus; spray drying; freeze drying</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1062-1068</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetes mellitus (DM) is associated with increased oxidative stress and higher mortality rates. Analysis is needed to identify compounds in natural foods that can prevent oxidative stress. According to previous studies, tender coconut waterwith added vitamin E is more effective in preventing oxidative stress caused by DM compared to plain tender coconut water. This development is necessary to provide added value and practicality. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the potential of tender coconut water powder inriched with vitamin E on male rats diabetes by measuring the oxidative stress (SOD, GPx, MDA, IL-1, IL-6, TNF-α, and CRP levels). &lt;strong&gt;Methods:&lt;/strong&gt; An experimental method was used with a posttest control group design. A total of 36 male Wistar rats used were randomly divided into 6 groups namely normal; DM; P1 (type 2 DM + Spray Drying tender coconut water powder); P2 (type 2 DM + Spray Drying tender coconut water powder + vitamin E); P3 (type 2 DM + Freeze Drying tender coconut water powder); and P4 (type 2 DM + Freeze Drying tender coconut water powder + vitamin E). Type 2 DM induction was carried out using Streptozotocin (STZ) 65 mg/kgBW and Nicotinamide 230 mg/kgBW. Tender coconut water powder was administered daily for 4 weeks beginning on the 3rd day after inducing DM. The data obtained were analyzed using the One Way Analysis of Variance test (ANOVA).&lt;strong&gt; Result:&lt;/strong&gt; The results showed that the average levels of SOD and GPx in P4 were higher compared to P2, while MDA, IL-1, IL-6, TNF α, and CRP in P4 were lower compared to P2. &lt;strong&gt;Conclusion: &lt;/strong&gt;Tender coconut water powder enriched with vitamin E effectively prevented oxidative stress, as indicated by increased SOD and GPx, along with decreased MDA, IL-1, IL-6, TNF α, and CRP levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1062</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ratnawati Ratnawati&lt;sup&gt;1&lt;/sup&gt;, Siti Thomas Zulaikhah&lt;sup&gt;1*&lt;/sup&gt;, Atina Hussaana&lt;sup&gt;2&lt;/sup&gt;, Arrizki Azka Pratama&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Universitas Islam Sultan Agung Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Universitas Islam Sultan Agung Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Neurology Resident, Faculty of Medicine, Universitas Diponegoro Semarang, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herry Cahya Fathani</style></author><author><style face="normal" font="default" size="100%">Herdiani Sulistyo Putri</style></author><author><style face="normal" font="default" size="100%">Prananda Surya Airlangga</style></author><author><style face="normal" font="default" size="100%">Christrijogo Sumartono Waloejo</style></author><author><style face="normal" font="default" size="100%">Ira Sari Yudaniayanti</style></author><author><style face="normal" font="default" size="100%">Pudji Lestari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effective Dose of Cocoa as a Preemptive Analgesic and Anti- Inflammatory Agent Assessed through Pain Scale and Tumor Necrosis Factor Alpha (TNF-α) in an Acute Pain Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cocoa</style></keyword><keyword><style  face="normal" font="default" size="100%">Pain</style></keyword><keyword><style  face="normal" font="default" size="100%">Pain Degree Analgesia</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1134-1137</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pain is a significant issue for 40-50% of hospital patients, with 10-50% of acute pain cases potentially progressing to chronic pain. Pain-associated inflammation often involves the release of mediators, including Tumor Necrosis Factor Alpha (TNF-&lt;strong&gt;α&lt;/strong&gt;). Cocoa beans contain polyphenols, catechins, anthocyanidins, and proanthocyanidins, compounds believed to possess analgesic properties. This study aims to assess cocoa's potential as an oral preemptive analgesic agent in an acute pain mouse model, with an emphasis on its impact on inflammation through TNF-&lt;strong&gt;α&lt;/strong&gt; levels.&lt;strong&gt; Methods: &lt;/strong&gt;This true experimental study involved 24 male white mice split into four groups: a control group (K0) receiving a placebo, a treatment group receiving 15 mg/kg BW oral paracetamol (Kpct), a treatment group receiving 0.5 mg/g BW cocoa (K1), and a treatment group receiving 1 mg/g BW cocoa (K2). Pain response was measured using TNF-&lt;strong&gt;α&lt;/strong&gt; levels and the von Frey test. The Kruskal-Wallis test and One-Way ANOVA were employed for statistical analysis. &lt;strong&gt;Results: &lt;/strong&gt;Cocoa at doses of 0.5 mg/g BW and 1 mg/g BW substantially reduced TNF-&lt;strong&gt;α&lt;/strong&gt; levels (75.82 ± 7.77 and 70.79 ± 11.50, respectively) compared to the control and paracetamol groups (98.22 ± 14.74 and 92.81 ± 2.64). On the first day, compared to the control group's 1.82 ± 0.78 von Frey values, the cocoa-treated groups' values (6.20 ± 2.72 and 7.63 ± 4.11) were notably higher. There were no notable variations in von Frey values across the groups on the second day. However, a correlation was found between von Frey values on the first and second days. &lt;strong&gt;Conclusion:&lt;/strong&gt; Cocoa can potentially serve as an effective preemptive analgesic agent, reducing pain and inflammation primarily by reducing TNF-&lt;strong&gt;α&lt;/strong&gt; levels. These results provide validity to the use of cocoa as an alternative therapy in acute pain management.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1134</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herry Cahya Fathani&lt;sup&gt;1,2&lt;/sup&gt;, Herdiani Sulistyo Putri&lt;sup&gt;1,2*&lt;/sup&gt;, Prananda Surya Airlangga&lt;sup&gt;1,2&lt;/sup&gt;, Christrijogo Sumartono Waloejo&lt;sup&gt;1,2&lt;/sup&gt;, Ira Sari Yudaniayanti&lt;sup&gt;3&lt;/sup&gt;, Pudji Lestari&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology and Intensive Care, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Indra Sampe Parimba</style></author><author><style face="normal" font="default" size="100%">Arief Bakhtiar</style></author><author><style face="normal" font="default" size="100%">Soedarsono Soedarsono</style></author><author><style face="normal" font="default" size="100%">Riyanarto Sarno</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effectiveness of Armpit Sweat Odor with COVID-19 Detection Device for Detecting COVID-19</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Armpit sweat odor</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19 detection device</style></keyword><keyword><style  face="normal" font="default" size="100%">RT-PCR</style></keyword><keyword><style  face="normal" font="default" size="100%">VOC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">691-697</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Coronavirus disease 2019 (COVID-19) is a disease caused by the SARS-CoV-2 virus. Diagnosis and screening for COVID-19 are crucial in controlling the disease. RT-PCR is used for diagnosis. However, this test is high-risk, time-consuming, and expensive. There is a need for specific non-invasive biomarkers to detect COVID-19 rapidly. Volatile organic compounds (VOCs) produced by the human body can be used to depict metabolic conditions. A COVID-19 detection device is an electronic device designed to differentiate and detect odors. This study aims to assess the effectiveness of armpit sweat odor with a COVID-19 detection device to detect COVID-19. This study was an observational analytic study with a cross-sectional design conducted on COVID-19 and non-COVID-19 patients in the special isolation ward of Dr. Soetomo Hospital and the outpatient clinic of the Indonesian Navy Hospital during April 2021-December 2021. COVID-19 examination using armpit sweat odor with a COVID-19 detection device. The results of the COVID-19 detection device and RT-PCR were then compared using the McNemar test. The general characteristics of the 168 subjects (81 COVID-19 patients, 87 non-COVID-19 patients) showed that the most common gender was male with the most common comorbidities being hypertension and diabetes mellitus. The results of the diagnostic test showed sensitivity and specificity of 88.9% and 97.7%, respectively with accuracy of 93.45%. The McNemar test showed no significant difference with the RT-PCR results. The results of RT-PCR were not different from the results of armpit sweat odor using COVID-19 detection device.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">691</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Indra Sampe Parimba&lt;sup&gt;1&lt;/sup&gt;, Arief Bakhtiar&lt;sup&gt;1&lt;/sup&gt;*, Soedarsono Soedarsono&lt;sup&gt;1&lt;/sup&gt;, Riyanarto Sarno&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pulmonology and Respiratory Medicine, Dr. Soetomo General Hospital Surabaya, Airlangga University INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Informatics, Faculty of Intelligent Electrical and Informatics Technology, Institut Teknologi Sepuluh Nopember (ITS) Surabaya INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Misroh Mulianingsih</style></author><author><style face="normal" font="default" size="100%">Suriah Suriah</style></author><author><style face="normal" font="default" size="100%">Healthy Hidayanty</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Veny Hadju</style></author><author><style face="normal" font="default" size="100%">Dea Wulandari</style></author><author><style face="normal" font="default" size="100%">Andi Ummu Salmah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effectiveness of Booklet and Images Game Education in Anemia Adolescent Women on Anemia Prevention Knowledge, Attitudes and Behavior</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adolescent women</style></keyword><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Attitudes</style></keyword><keyword><style  face="normal" font="default" size="100%">Behavior</style></keyword><keyword><style  face="normal" font="default" size="100%">Booklet</style></keyword><keyword><style  face="normal" font="default" size="100%">Image Game Education</style></keyword><keyword><style  face="normal" font="default" size="100%">knowledge</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1183-1187</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background :&lt;/strong&gt; Risk factors for anemia in adolescents are lack of education, as well as adolescents inability to apply the information obtained in daily life. Effective health education improving adolescents knowledge, attitudes, and behaviors related to health. &lt;strong&gt;Objective :&lt;/strong&gt; This study aims to test the effectiveness of Booklet and Image game education in adolescent girls on knowledge, attitudes, and behaviors to prevennt anemia. Participants were young women aged 15-19 years in the work area of the bayan Health Center and Gangga Health Center, who were selected through a screening process of 186 participants. each location had 93 respondents. &lt;strong&gt;Method : &lt;/strong&gt;usiang a quasi-experimental two-group pre-test post-test design. In both groups, a pre-test was carried out furthermore, the intervention group was given health education through booklets and image game education, and the control group received health education with booklets. After the intervention was carried out, a pot-test was carried out on both groups. &lt;strong&gt;Results : &lt;/strong&gt;Coherence analysis showed that the control group (booklet), adolescent girl with anemia who received the booklet and image game education in the intervention group reported better knowledge about anemia (p=0,000, n2 p=0,727)attitudes about anemia (p=0,000, n2 p=0,698), and behavior of adolescent girls with anemia between the intervention group and the control group were much different after being given with anemia between the intervention group and the control group were much different after being given booklets and image game education compared to adolescent girls who only received booklets. &lt;strong&gt;Conclusion :&lt;/strong&gt; A multifaceted approach to health education can have a significant positive impact, especially when it involves interactive elements.therefore, the same educational program can be applied in various places to increase the effectiveness of a program or activity goal&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1183</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Misroh Mulianingsih&lt;sup&gt;1,5&lt;/sup&gt;, Suriah Suriah&lt;sup&gt;2&lt;/sup&gt;, Healthy Hidayanty&lt;sup&gt;3&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;4&lt;/sup&gt;, Veny Hadju&lt;sup&gt;3&lt;/sup&gt;, Dea Wulandari&lt;sup&gt;5&lt;/sup&gt;, Andi Ummu Salmah&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Study Program, Faculty of Public Health, Hasanuddin University – INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Promotion and Behavioral Sciences, Faculty of Public Health, Hasanuddin University INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Nutrition, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Mataram Yarsi College of Health Sciences, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biostatistics and Demographics, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Acce Basri</style></author><author><style face="normal" font="default" size="100%">Syamsiar Russeng</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Masni Masni</style></author><author><style face="normal" font="default" size="100%">Muhammad Safar</style></author><author><style face="normal" font="default" size="100%">Siti Muslimatun</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of ADCES7 Self Care Behavior Application and Acupressure on Changes in Blood Glucose Levels in Obesive, Prediabetic Women</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acupressure</style></keyword><keyword><style  face="normal" font="default" size="100%">ADCES7 Self Care Behavior.</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Prediabetes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">744-750</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Prediabetes and obesity in women are important health problems today. Appropriate selfmanagement and other methods are needed to overcome this. Objective: To assess the magnitude of the difference in changes in fasting blood glucose levels, before and after carrying out ADCES7 self-care behavior and acupressure. &lt;strong&gt;Method: &lt;/strong&gt;This research is quasi-experimental research. The research design used was the Non-Randomized Pre Test - Post Test Control Group, which gathered obese, prediabetic women in the Kalumata Community Health Center, Siko Community Health Center and Posbindu under the PKK Ternate City through screening by excluding those who had suffered from diabetes mellitus and were pregnant. This group was then divided into the ADCES7 self care behavior intervention group, the acupressure group and the combined ADCES7 self care behavior and acupressure group. Multivariate logistic regression was used to assess changes in fasting blood glucose levels. &lt;strong&gt;Results:&lt;/strong&gt; Respondents in this study were 102 people who were divided into three groups. The results showed that there was an effect of Self Management intervention p(0.016)&amp;lt;0.05, acupressure intervention p(0.032)&amp;lt;0.05, and the combination group of Self Management and Acupressure p(0.011)&amp;lt;0.05 on changes in fasting blood glucose levels in prediabetic obese women. &lt;strong&gt;Conclusion:&lt;/strong&gt; obese prediabetic women who are aware and active in self-management ACDES7 self care behavior and acupressure can reduce blood glucose levels and body weight in obese prediabetic women&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">744</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Acce Basri&lt;sup&gt;1*&lt;/sup&gt;, Syamsiar Russeng&lt;sup&gt;2&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;3&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;4&lt;/sup&gt;, Yahya Thamrin&lt;sup&gt;5&lt;/sup&gt;, Masni Masni&lt;sup&gt;6&lt;/sup&gt;, Muhammad Safar&lt;sup&gt;7&lt;/sup&gt;, Siti Muslimatun&lt;sup&gt;8&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;9&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Degree of Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2,&lt;/sup&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Nutrition science, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Statistics and Demography, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Health Promotion and Behaviour Science, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Food Science and Nutrition Indonesia International Institute for Life Sciences, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herdina Ramadhani</style></author><author><style face="normal" font="default" size="100%">Indri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Ismi Zuhria</style></author><author><style face="normal" font="default" size="100%">Firman Setiawan</style></author><author><style face="normal" font="default" size="100%">Annise Proboningrat</style></author><author><style face="normal" font="default" size="100%">Djoko Legowo</style></author><author><style face="normal" font="default" size="100%">Diah Indriani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Bacteriophage in Postoperative Endophthalmitis Caused by Staphylococcus aureus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">bacteriophage</style></keyword><keyword><style  face="normal" font="default" size="100%">postoperative endophthalmitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus aureus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1188-1191</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Postoperative endophthalmitis is a serious complication of cataract surgery. It may leads to vision loss. The most common organism cause endophthalmitis is gram-positive bacteria, mainly &lt;em&gt;Staphylococcus aureus&lt;/em&gt; (&lt;em&gt;S. aureus&lt;/em&gt;). To prevent postoperative endophthalmitis, eye drops or intracameral administration of antibiotic agents are universally used. In recent years, the trend of endophthalmitis treatment has grown rapidly. Administration of bacteriophage is a subject of research for the treatment and prophylaxis of postoperative endophthalmitis. This literature review investigates the potential of bacteriophage to provide a rapid, effective alternative to antibiotic treatments for postoperative endophthalmitis caused by &lt;em&gt;S. aureus&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1188</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herdina Ramadhani&lt;sup&gt;1,2&lt;/sup&gt;, Indri Wahyuni&lt;sup&gt;1,2*&lt;/sup&gt;, Ismi Zuhria&lt;sup&gt;1,2&lt;/sup&gt;, Firman Setiawan&lt;sup&gt;3,4&lt;/sup&gt;, Annise Proboningrat&lt;sup&gt;5&lt;/sup&gt;, Djoko Legowo&lt;sup&gt;5&lt;/sup&gt;, Diah Indriani&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Ophthalmology, Faculty of Medicine Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Ophthalmology, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Microbiology, Faculty of Medicine Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Microbiology, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Veterinary Pathology, Faculty of Veterinary Medicine Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Faculty of Public Health Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Arifin Parenrengi</style></author><author><style face="normal" font="default" size="100%">Ahmad Data Dariansyah</style></author><author><style face="normal" font="default" size="100%">Wihasto Suryaningtyas</style></author><author><style face="normal" font="default" size="100%">Dyah Fauziah</style></author><author><style face="normal" font="default" size="100%">I Ketut Sudiana</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Prastiya Indra Gunawan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Cerebrospinal Fluid Drainage on Pro-Inflammatory and Anti-Inflammatory Cytokines Expression in the Subventricular Zone of Kaolin-Induced Hydrocephalic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">cerebrospinal fluid drainage</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokines</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaolin-induced hydrocephalus</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroinflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">subventricular zone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">20-27</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; To determine the neuroprotective effect of CSF drainage by analyzing its impact on the expression and the ratio of pro- and anti-inflammatory cytokines in the subventricular zone in kaolininduced hydrocephalic rats. &lt;strong&gt;Method:&lt;/strong&gt; Sprague-Dawley rats of 23 weeks of age (n=36) were used in this study. The rats were randomly divided into normal control, hydrocephalus, and CSF drainage-treated groups. Hydrocephalus was obtained by injecting 0,05 cc of 20% kaolin suspension into the cisterna magna. The CSF drainage-treated group had ventricular tapping seven days after kaolin induction. The rats were sacrificed 7, 14, or 21 days after kaolin induction. The brain was removed and prepared for immunohistochemistry analysis to detect IL-1&lt;em&gt;β&lt;/em&gt;, IL-6, TNF-&lt;em&gt;α&lt;/em&gt;, and IL-10 cytokines expression. &lt;strong&gt;Results: &lt;/strong&gt;Immunohistochemistry analysis revealed that the expression of pro-inflammatory cytokines was significantly increased in hydrocephalus groups than in the control group. In contrast, the expression of anti-inflammatory cytokine was significantly decreased. CSF drainage had a neuroprotective effect by reducing pro-inflammatory cytokine expression and increasing anti-inflammatory cytokine expression. In the hydrocephalus group, the ratios of IL-1&lt;em&gt;β&lt;/em&gt;/IL-10, IL-6/IL-10, and TNF-&lt;em&gt;α&lt;/em&gt;/IL-10 increased toward a pro-inflammatory status. After CSF drainage, the ratios of IL-1&lt;em&gt;β&lt;/em&gt;/IL-10, IL-6/IL-10, and TNF-&lt;em&gt;α&lt;/em&gt;/IL-10 shifted toward an anti-inflammatory status. &lt;strong&gt;Conclusion: &lt;/strong&gt;CSF drainage protects the brain from excessive neuroinflammatory processes in kaolin-induced hydrocephalic rats. Additional investigation is warranted to ascertain the use of inflammatory cytokines expression as a valuable biomarker for hydrocephalus. Furthermore, research on anti-inflammatory drug administration in clinical settings is required.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">20</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Muhammad Arifin Parenrengi&lt;sup&gt;1,*&lt;/sup&gt;, Ahmad Data Dariansyah&lt;sup&gt;1&lt;/sup&gt;, Wihasto Suryaningtyas&lt;sup&gt;1&lt;/sup&gt;, Dyah Fauziah&lt;sup&gt;2&lt;/sup&gt;, I Ketut Sudiana&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;, Prastiya Indra Gunawan&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herpramanto Dwi Susetyo</style></author><author><style face="normal" font="default" size="100%">Sri Ratna Dwiningsih</style></author><author><style face="normal" font="default" size="100%">Widjiati</style></author><author><style face="normal" font="default" size="100%">I Wayan Arsana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effects of Increasing Doses of Nigella Sativa and Conjugated Estrogen on Bone-Specific Alkaline Phosphatase (B-ALP), Procollagen Type 1 N-Terminal Propeptide (P1NP), Carboxy Terminal Crosslinked Telopeptide of Type 1 Collagen (CTX-1), and Osteoprotege</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">B-ALP</style></keyword><keyword><style  face="normal" font="default" size="100%">Bone biomarkers</style></keyword><keyword><style  face="normal" font="default" size="100%">Estrogen conjugation</style></keyword><keyword><style  face="normal" font="default" size="100%">Nigella sativa</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteoporosis rats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1-5</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Osteoporosis is characterized by decreased bone density, increasing the risk of fractures. Hormone therapy for post-menopausal osteoporosis has side effects, prompting the development of Nigella sativa (black cumin) as an alternative treatment. &lt;strong&gt;Objective: &lt;/strong&gt;This study aims to determine the effect of administering Nigella sativa and conjugated estrogen as osteoporosis therapy in rats treated with bilateral oophorectomy, which have been verified as having osteoporosis based on bone biomarkers. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;This study involved 72 female Wistar rats divided into six groups: K+ (positive control), K- (negative control), P1 (receiving conjugated estrogen), P2 (receiving 100 mg/kg BW of Nigella sativa), P3 (receiving 200 mg/kg BW of Nigella sativa, and P4 (receiving 400 mg/kg BW of Nigella sativa. After inducing post-menopausal osteoporosis through bilateral oophorectomy, the treatment groups received therapy for 28 days. Bone biomarkers such as bone-specific alkaline phosphatase (bALP), procollagen type 1 n-terminal propeptide (P1NP), carboxy-terminal crosslinked telopeptide of type 1 collagen (CTX-1), and osteoprotegerin (OPG) were measured using ELISA. &lt;strong&gt;Results: &lt;/strong&gt;The 400 mg/kg BW administration of Nigella sativa significantly increased bALP and P1NP levels, indicating higher osteoblast activity. At the same dose, Nigella sativa also increased OPG levels, suppressing osteoclastogenesis in bone resorption. However, 100-400 mg/kg BW/day of Nigella sativa did not reduce CTX-1 levels, nor did it inhibit osteoclasts in bone resorption. Estrogen conjugation also increased OPG levels but did not significantly affect bALP and P1NP levels. &lt;strong&gt;Conclusion: &lt;/strong&gt;Nigella sativa at a dose of 400 mg/kg BW significantly increases osteoblast activity and OPG levels. Estrogen conjugation increases OPG levels but does not affect bALP and P1NP. Nigella sativa can potentially serve as an effective alternative therapy for osteoporosis through a mechanism different from conjugated estrogen.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herpramanto Dwi Susetyo&lt;sup&gt;1&lt;/sup&gt;, Sri Ratna Dwiningsih&lt;sup&gt;2&lt;/sup&gt;, Widjiati&lt;sup&gt;3*&lt;/sup&gt;, I Wayan Arsana&lt;sup&gt;2,4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Fertility Endocrinology and Reproduction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Fertility Endocrinology and Reproduction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rasha M. Salim</style></author><author><style face="normal" font="default" size="100%">Sarmad S. S. Al Qassar</style></author><author><style face="normal" font="default" size="100%">Aisha A. Qasim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Magnesium Gel and Diode Laser in Combination on the Color Masking of Artificial White Spot Lesions: An in Vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">color</style></keyword><keyword><style  face="normal" font="default" size="100%">Diode laser</style></keyword><keyword><style  face="normal" font="default" size="100%">Magnesium</style></keyword><keyword><style  face="normal" font="default" size="100%">White spot lesion.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">757-763</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective&lt;/strong&gt;: White spot lesions are one of the most common problem during and after orthodontic therapy. The present study was accomplished to evaluate the ability of Magnesium gel at different concentration and diode laser in combination compared with commercially available 1.23%APF in color restoring of WSL on permanent teeth. &lt;strong&gt;Materials and Methods&lt;/strong&gt;: In this in vitro study, 42 human caries-free premolar teeth were randomely divided into 6 experimental groups: Group A: Control (artificial saliva), Group B: 0.5%MgCl&lt;sub&gt;2&lt;/sub&gt; gel, Group C: 1%MgCl&lt;sub&gt;2 &lt;/sub&gt;gel, Group D: 0.5%MgCl&lt;sub&gt;2&lt;/sub&gt; gel and Diode laser, Group E: 1%MgCl&lt;sub&gt;2&lt;/sub&gt; gel and Diode laser and Group F: 1.23%APF. The difference between the displayed color and the original color standard (ΔE) was assessed by colorimeter. The surface topography of teeth samples from each tested group was examined by a SEM. Collected data were investigated using one-way ANOVA followed by Duncan post hoc test at p ≤ 0.05. &lt;strong&gt;Result: &lt;/strong&gt;A significant difference in (ΔE) was noticed among groups (&lt;em&gt;p&lt;/em&gt;= 0.006). Group (B) showed the lowest ΔE value (9.4±1.6), followed by group (D) (10.2±1.1), group (F) (10.4±2.6), group (A) (11.6±1.3), group (C) (12.9 ±2.3) and group (E) (13.2±1.3). &lt;strong&gt;Conclusion:&lt;/strong&gt; 0.5% magnesium gel is as 1.23% APF gel in color restoring of white spot lesion. No synergistic effect between materials and diode laser.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">757</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Rasha M. Salim&lt;sup&gt;1*&lt;/sup&gt;, Sarmad S. S. Al Qassar&lt;sup&gt;2&lt;/sup&gt;, Aisha A. Qasim&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Master student,&amp;nbsp;BDS, Department of Pedo Ortho Prevention, College of Dentistry, University of Mosul, Mosul, IRAQ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Dr. Department of&amp;nbsp;Pedo Ortho Prevention, College of Dentistry, University of Mosul, Mosul, IRAQ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Professor, Department of Pedo Ortho Prevention, College of Dentistry, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Putu Virgina Angga Saraswati</style></author><author><style face="normal" font="default" size="100%">Mahrus Abdur Rahman</style></author><author><style face="normal" font="default" size="100%">Risky Vitria Prasetyo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Magnesium Supplementation on the Carotid Intima Media Thickness in Children with Chronic Kidney Disease and Hyperphosphatemia: A Double-blind Randomized Clinical Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carotid Intima Media Thickness</style></keyword><keyword><style  face="normal" font="default" size="100%">Children</style></keyword><keyword><style  face="normal" font="default" size="100%">Chronic Kidney Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperphosphatemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Magnesium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1056-1061</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Hyperphosphatemia has been emphasized to be a significant risk factor for vascular calcification in CKD patients. This study aims to investigate the effect of magnesium supplementation on the reduction of phosphate levels and carotid intima media thickness in children as predictor on vascular calcification with CKD and hyperphosphatemia, compared to a placebo.&lt;strong&gt; Methods:&lt;/strong&gt; A randomized, double-blind, placebo-controlled trial was conducted at Pediatric Ward and Outpatient Clinic of Pediatric Nephrology in our setting during October-March 2023. We compared oral magnesium supplementation (6 mg/kg body weight/day for two months) with a placebo in children with CKD and hyperphosphatemia (ages 1-18 years old). Patients who were on dialysis and had serum magnesium levels of &amp;lt;1.6 mg/dL and &amp;gt;2.4 mg/dL, and were allergic to magnesium supplementation were excluded. A paired T-test and the Wilcoxon signed-rank test were used for statistical analysis. &lt;strong&gt;Results:&lt;/strong&gt; We collected 25 children in the experimental group and 25 children in the placebo group. Phosphate levels were decreased in both the magnesium supplementation and placebo groups (6.1 ± 0.79 to 6.0 ± 0.63 mg/dL; p-value = 0.852 and 6.01 ± 0.55 to 5.8 ± 0.64 mg/dL; p-value=0.365). However, when compared between groups, the reductions were not significantly different (0.1 vs 0.21; p-value=0.935). A significant improvement was found in carotid intima media thickness in both groups (0.05±0.01 to 0.05±0.01; p-value=0.000 and 0.05±0.01 to 0.05±0.01; p-value=0.000), and the reductions were significantly different (0.01 vs 0.01; p-value=0.000). &lt;strong&gt;Conclusion: &lt;/strong&gt;Magnesium supplements have considerably lower phosphate levels and significantly reduced the thickness on carotid intima media in children with CKD and hyperphosphatemia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1056</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Putu Virgina Angga Saraswati&lt;sup&gt;1,2&lt;/sup&gt;, Mahrus Abdur Rahman&lt;sup&gt;1,2&lt;/sup&gt;, Risky Vitria Prasetyo&lt;sup&gt;1,2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Child Health, Dr Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Child Health, Faculty of Medicine- Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Octarina Ervianti</style></author><author><style face="normal" font="default" size="100%">Wimbo Sasono</style></author><author><style face="normal" font="default" size="100%">Reni Prastyani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effects of Melon Superoxide Dismutase and Gliadin on Glutathione Reductase (GSH) and Superoxide Dismutase (SOD) Levels in Blood Plasma and Vitreoretina in Diabetic Rat Model: A Literature Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Blood Plasma</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Glisodin®</style></keyword><keyword><style  face="normal" font="default" size="100%">GSH</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitreoretina</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1202-1208</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Chronic hyperglycemia in diabetics causes microvascular damage through four mechanisms of biochemical changes, including activated protein kinase C (PKC) pathway, activated hexosamine pathway, increased polyol pathway, and increased advanced glycation end-products (AGEs), all of which will increase Reactive Oxygen Species (ROS) levels. ROS can damage proteins, nucleic acids, and lipids and hasten the onset of diabetes. ROS are produced in the presence of normal blood sugar levels, and the natural breakdown of glucose is controlled by insulin. Variables that regulate cellular respiration, including NAD-related substrates, oxygen, succinate, and antioxidant enzymes, modulate ROS levels and sustain cellular redox equilibrium. The conversion of superoxide anions into hydrogen peroxide, before subsequently metabolized into water by catalase and glutathione (GSH) peroxidase, is facilitated by the metalloprotein superoxide dismutase (SOD). Increased ROS levels can lead to diabetic complications, one of which is diabetic retinopathy. Melon superoxide dismutase (SOD) combined with gliadin (Glisodin&lt;sup&gt;®&lt;/sup&gt;) is a potent antioxidant in counteracting free radicals that can reduce oxidative stress and prevent further cell death. Research related to the use of Glisodin&lt;sup&gt;® &lt;/sup&gt;shows potential as an antioxidant agent with the hope of preventing diabetic complications.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1202</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Octarina Ervianti, Wimbo Sasono*, Reni Prastyani&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Ophthalmology, Dr. Soetomo General Academic Hospital / Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chutharat Saereewat</style></author><author><style face="normal" font="default" size="100%">Kusuma Sriyakul</style></author><author><style face="normal" font="default" size="100%">Parunkul Tungsukruthai</style></author><author><style face="normal" font="default" size="100%">Sunyarn Niempoog</style></author><author><style face="normal" font="default" size="100%">Sucharat Tungsukruthai</style></author><author><style face="normal" font="default" size="100%">Chuntida Kamalashiran</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy and Safety of Traditional Transdermal Patch (Ya-Pok- Dud-Pid) in Primary Knee Osteoarthritis Patients: A Randomized Controlled Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diclofenac</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteoarthritis of knee</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional</style></keyword><keyword><style  face="normal" font="default" size="100%">Transdermal Patch</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">570-575</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Patients with Knee Osteoarthritis (KOA) have a progressive decline in their social and physical abilities, which affects their quality of life. The Thai Traditional Transdermal Patch (Ya-Pok-Dud- Pid; YP) has been widely used for the treatment of KOA. &lt;strong&gt;Objective:&lt;/strong&gt; To determine the clinical efficacy and safety of YP in comparison with diclofenac gel (DG) for the treatment of KOA.&lt;strong&gt; Methods:&lt;/strong&gt; 74 primary KOA Patients were enrolled and randomly assigned to YP groups or DG groups. The outcomes were assessed the Visual Analog Scale (VAS), Time Up and Go (TUG), Active Knee Flexion (AKF) and Passive Knee Flexion, chair sit and reach, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). &lt;strong&gt;Results:&lt;/strong&gt; YP and DG significantly improved VAS, TUG, AKF, PKF, chair sit and reach, and WOMAC (p &amp;lt; 0.05). Remarkably, YP experienced the same immediate pain relief after day 1 treatment as DG. The VAS scores of the YP group exhibited a significant reduction from 60±11.06 to 38.92±17.76, while DG decreased VAS score from 61.24±17.84 to 39.19±20.05 (p &amp;lt;0.001). However, there was no significant difference between the two treatment groups. For adverse event, skin reaction (rash, itchy, and dry skin) was noted in the YP group because of the participant receiving YP for an extended period. Altogether, YP has a similar effect to diclofenac gel on pain severity and physical function in patients with knee osteoarthritis. &lt;strong&gt;Conclusion:&lt;/strong&gt; YP is recommended as a natural therapeutic agent with efficacy and safety treatment for knee osteoarthritis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">570</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Chutharat Saereewat&lt;sup&gt;1&lt;/sup&gt;, Kusuma Sriyakul1, Parunkul Tungsukruthai&lt;sup&gt;1&lt;/sup&gt;, Sunyarn Niempoog&lt;sup&gt;2&lt;/sup&gt;, Sucharat Tungsukruthai&lt;sup&gt;3&lt;/sup&gt;, Chuntida Kamalashiran&lt;sup&gt;1&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Integrative Medicine, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathum Thani, 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Orthopedic, Thammasat University (Rangsit Campus), Pathum Thani, 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neni Wahyu Hastuti</style></author><author><style face="normal" font="default" size="100%">Delfitri Munir</style></author><author><style face="normal" font="default" size="100%">Reno Keumalazia Kamarlis</style></author><author><style face="normal" font="default" size="100%">Bintang Yinke Magdalena Sinag</style></author><author><style face="normal" font="default" size="100%">Adang Bachtiar</style></author><author><style face="normal" font="default" size="100%">Farhat</style></author><author><style face="normal" font="default" size="100%">Amira Permatasari Tarigan</style></author><author><style face="normal" font="default" size="100%">Delyuzar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Eosinophil Cell and Mass Appearance in Atypical Mycobacterium Infection of Lymphadenitis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Atypical mycobacterium</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytology</style></keyword><keyword><style  face="normal" font="default" size="100%">Eosinophil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">664-667</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Atypical mycobacterium (ATM) is acid fast bacilli not including tuberculosis and may had opportunistic feature in environment either in air or soil. While symptoms of ATM infection may look similar with typical tuberculosis, these specific group of disease were harder to treat and would necessitate longer antibiotics consumption. While PCR may readily available to detect ATM, anatomical pathology method such as biopsy may be a cheaper alternative in low-resource settings to differentiate between atypical and typical mycobacterium infection. &lt;strong&gt;Aim:&lt;/strong&gt; To analyze correlation between eosinophil cells and eosinophil mass with ATM in lymphadenopathy patient. &lt;strong&gt;Methods: &lt;/strong&gt;This study is an analytical observational study with cross-sectional design which aimed to review diagnostic abilities of eosinophil cell and mass to detect ATM. Patient would undergo both PCR as gold standard of diagnosis and cytology biopsy aspiration as comparative diagnostic modalities. Data would be presented from SPSS v. 25. &lt;strong&gt;Results:&lt;/strong&gt; We collected 70 subjects that fulfill inclusion and exclusion criteria. Most samples were dominated by female in relatively young age. There are 37 patients with ATM in which 75,7% patients cytology result shown expression of eosinophil cells and 71,4% patients shown eosinophilic mass. Chi-square test revealed that statistical significance existed between eosinophilic cells with ATM. However, such statistical significance was not found between eosinophilic mass and ATM. &lt;strong&gt;Conclusion:&lt;/strong&gt; Eosinophilic cell can be used as alternative diagnostic modalities in diagnosing ATM. Further studies should further examine pathophysiological correlations and diagnostic power.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">664</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Neni Wahyu Hastuti&lt;sup&gt;1&lt;/sup&gt;*, Delfitri Munir&lt;sup&gt;2&lt;/sup&gt;, Reno Keumalazia Kamarlis&lt;sup&gt;3&lt;/sup&gt;, Bintang Yinke Magdalena Sinaga&lt;sup&gt;4&lt;/sup&gt;, Adang Bachtiar&lt;sup&gt;5&lt;/sup&gt;, Farhat&lt;sup&gt;2&lt;/sup&gt;, Amira Permatasari Tarigan&lt;sup&gt;4&lt;/sup&gt;, Delyuzar&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;6&lt;/strong&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Philosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Ear, Nose, Throat, Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anatomical Pathology, dr Zainoel Abidien Hospital, Universitas Syiah Kuala, Banda Aceh, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Health Policy and Administration, School of Public Health, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nilsya Febrika Zebua</style></author><author><style face="normal" font="default" size="100%">Nerdy Nerdy</style></author><author><style face="normal" font="default" size="100%">Kanne Dachi</style></author><author><style face="normal" font="default" size="100%">Muflihah Fujiko</style></author><author><style face="normal" font="default" size="100%">Abdi Wira Septama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnomedicine In Nias Island</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethnobotanical</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnomedicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Nias</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">186-194</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Medicinal plants have an important role in the traditional medicine system of the Nias people, which has been passed down from generation to generation. Although there has been some ethnobotanical research in Indonesia, especially in Nias, studies regarding people's knowledge, use and perception of medicinal plants on this island are still very limited. &lt;strong&gt;Objective: &lt;/strong&gt;to investigate the knowledge, use and perceptions of the Nias community towards medicinal plants. &lt;strong&gt;Design:&lt;/strong&gt; The research population involved communities in various areas of Nias, and samples were taken randomly from several villages or communities. Data collection methods include questionnaires, interviews, and observations to detail the use of medicinal plants, local knowledge, and factors that influence the choice and use of medicinal plants. The research variables involve the demographic characteristics of respondents, education level, access to health information as independent variables, while the dependent variables include the use of medicinal plants and knowledge about medicinal plants.&amp;nbsp;&lt;strong&gt;Results:&lt;/strong&gt; As a result of data collection on respondents on Nias Island, there were 50 medicinal plants that people have often used for generations to treat diseases. Data analysis involved analyzing factors related to the use of medicinal plants. It is hoped that this research will provide a better understanding of the use of medicinal plants in Nias and contribute to the preservation of local knowledge and the development of public health strategies. &lt;strong&gt;Conclusion: &lt;/strong&gt;Most of the empirical data submitted by the local Nias community is in accordance with research that has been carried out, however, there are 13 plants that need to be explored further because the empirical data does not match.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">186</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nilsya Febrika Zebua&lt;sup&gt;1&lt;/sup&gt;*, Nerdy Nerdy&lt;sup&gt;2&lt;/sup&gt;, Kanne Dachi&lt;sup&gt;3&lt;/sup&gt;, Muflihah Fujiko&lt;sup&gt;4&lt;/sup&gt;, Abdi Wira Septama&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Tjut Nyak Dhien, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Tjut Nyak Dhien, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Tjut Nyak Dhien, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Tjut Nyak Dhien, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Research Center for Pharmaceutical Ingredient and Traditional Medicine, National Research and Innovation Agency (BRIN), Kawasan PUSPITEK Serpong, Tangerang Selatan, Banten, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nandakumar K N</style></author><author><style face="normal" font="default" size="100%">Mohanraj Nehru</style></author><author><style face="normal" font="default" size="100%">Prasanth Subramanian</style></author><author><style face="normal" font="default" size="100%">Bhuvaneshwaran Mothiswaran</style></author><author><style face="normal" font="default" size="100%">Vishagan S S</style></author><author><style face="normal" font="default" size="100%">Satishkumar Rajappan Chandra</style></author><author><style face="normal" font="default" size="100%">Venkataraman Prabhu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluating the Efficacy of Cresvin beta on Type 2 Diabetes Mellitus Management: A Randomized Comparative Clinical Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes; Cresvin beta; Cardiovascular complications; Insulin resistance; Metformin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1219-1216</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;In this current state, Type 2 Diabetes Mellitus (T2DM) is more prevalent in the population, and metformin is used as a first-line medication for treating it, but gradually prevalence and incident rate of T2DM is increased. There was an upsurge in the utilization of alternative therapies in managing of diabetes. Especially in diabetes, Herbal medicines are considered safe and reliable by the majority of the population. This research aims to estimate the safety and efficacy of poly herbal metabolite compounds of Cresvin beta capsules in adults with T2DM. &lt;strong&gt;Methods:&lt;/strong&gt; In this study, 60 T2DM patients aged 18-60 years were randomly assigned to Groups A (30), receiving Metformin 500 mg twice a day after food, and Group B (30), receiving Cresvin beta capsule 500 mg twice a day, after food in a prospective, randomized and open-label clinical study. The in-silico simulation study was performed on selected plants major compounds on target protein Insulin-like Growth Factor-1 (1K3A). &lt;strong&gt;Results: &lt;/strong&gt;The Cresvin beta is found to be safe and effective in the management of T2DM. The FBS, PPBS and HbA1c were significantly lowered (p&amp;lt;0.001) in posttreatment in both the Metformin and Cresvin beta capsules. Similarly, the levels of IGF1, adiponectin, EL-1, IL-6, and TNF-α showed significant alteration (p&amp;lt;0.001) after the treatment. The alterations found in the post-treatment results of Cresvin beta, including the reduced levels of creatinine and triglycerides, express the efficacy. &lt;strong&gt;Conclusion:&lt;/strong&gt; The research results conclude, that the Cresvin beta capsule would be one of the suitable choices for increasing the efficacy in the management of diabetes mellitus.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1219</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nandakumar K N&lt;sup&gt;1&lt;/sup&gt;, Mohanraj Nehru&lt;sup&gt;1&lt;/sup&gt;, Prasanth Subramanian&lt;sup&gt;1&lt;/sup&gt;, Bhuvaneshwaran Mothiswaran&lt;sup&gt;2&lt;/sup&gt;, Vishagan S S&lt;sup&gt;3&lt;/sup&gt;, Satishkumar Rajappan Chandra&lt;sup&gt;3&lt;/sup&gt;, Venkataraman Prabhu&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Research, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, kattankulathur, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Trial and Research Unit, Interdisciplinary Institute of Indian System of Medicine, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chennai, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Director of Apex Laboratories Pvt Ltd, Chennai, Tamilnadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Faridz Syahrian</style></author><author><style face="normal" font="default" size="100%">I Nyoman Ehrich Lister</style></author><author><style face="normal" font="default" size="100%">Chrismis Novalinda Ginting</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluating the Therapeutic Potential of Vernonia amygdalina: A Promising Antidiabetic Agent in STZ and Nicotinamide-Induced Rat Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">HbA1c</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD</style></keyword><keyword><style  face="normal" font="default" size="100%">Vernonia amygdalina</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">94-99</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Vernonia amygdalina, commonly known as bitter leaf, has been traditionally used for its potential antidiabetic properties. This study aimed to evaluate the therapeutic potential of Vernonia amygdalina extract (VAE) in ameliorating hyperglycemia using a streptozotocin (STZ) and high-fat diet (HFD)-induced rat model of diabetes. &lt;strong&gt;Methods:&lt;/strong&gt; Sixty male Wistar rats were divided into six groups: normal control, diabetic control, and four treatment groups receiving different doses of VAE (100, 300, and 500 mg/kg body weight) orally for eight weeks. Diabetes was induced in rats by a single intraperitoneal injection of STZ (55 mg/kg) after four weeks of Nicotinamid feeding. Body weight, fasting blood glucose levels, HbA1c, serum insulin levels, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) levels were measured. &lt;strong&gt;Results: &lt;/strong&gt;Treatment with VAE significantly reduced fasting blood glucose levels in a dose-dependent manner compared to the diabetic control group (p &amp;lt; 0.05). VAE administration also led to a significant decrease in HbA1c levels and an increase in serum insulin levels in a dosedependent manner (p &amp;lt; 0.05). Furthermore, VAE supplementation restored SOD activity and reduced MDA levels, indicating improved antioxidant status in the treated groups (p &amp;lt; 0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;This study demonstrates the therapeutic potential of Vernonia amygdalina as an antidiabetic agent in the STZ and HFD-induced rat model of diabetes. VAE supplementation effectively reduced fasting blood glucose levels, improved glycemic control as indicated by reduced HbA1c levels, and enhanced insulin secretion. Moreover, VAE exhibited antioxidant activity by restoring SOD activity and reducing MDA levels. These findings suggest that Vernonia amygdalina could be a promising natural remedy for the management of diabetes. Further investigations are warranted to elucidate the underlying mechanisms and evaluate its long-term safety and efficacy in humans.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">94</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Faridz Syahrian*, I Nyoman Ehrich Lister, Chrismis Novalinda Ginting&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Medicine, Universitas Prima Indonesia, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Honnesh N H</style></author><author><style face="normal" font="default" size="100%">Santanu Saha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti-oxidant Activity and Flavonoid Content in Macaranga peltata Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Fraction</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP</style></keyword><keyword><style  face="normal" font="default" size="100%">Luteolin</style></keyword><keyword><style  face="normal" font="default" size="100%">Macaranga peltata</style></keyword><keyword><style  face="normal" font="default" size="100%">MPCF</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1217-1221</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Macaranga peltata is a woody shrub and tree found in forest of Western Ghats of India. The leaves of M. peltata are large so used to wrap sweets in kerala. The plant is used in folk medicine and siddha medicine to treat fever, cough, wound and ulcers. There is very limited research has been conducted on exploring this plant medicinal properties and phytochemical estimation. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; In the present study attempt was made to know the antioxidant activity of MPCF by DPPH assay, FRAP assay and H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; assay methods and Optimization of mobile phase by TLC method and supporting major flavonoid content quantification by HPTLC method &lt;strong&gt;Results:&lt;/strong&gt; The result shown the Chloroform fraction has significant antioxidant activity of IC&lt;sub&gt;50&lt;/sub&gt; value of 123.71(DPPH assay), 185.85(FRAP assay) and 204.31(H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; assay). The TLC method optimum mobile phase was found to be Toluene: Ethyl acetate: Formic acid (5:4:0.2). The standard flavonoids used are Luteolin, Diosmin and ellagic acid. The HPTLC method results shown MPCF was found to contain 11.70% Luteolin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1217</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Honnesh N H&lt;sup&gt;1&lt;/sup&gt;, Santanu Saha&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Nitte College of Pharmaceutical Sciences, 6429, NITTE Campus, Govindapura, Gollahalli, Yelahanka, Bangalore - 560 064, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Panner, Deralakatte, Mangaluru-575018, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">S Gopika</style></author><author><style face="normal" font="default" size="100%">MK Nisha</style></author><author><style face="normal" font="default" size="100%">E Gaayathiri Devi</style></author><author><style face="normal" font="default" size="100%">A Raja Rajeswari</style></author><author><style face="normal" font="default" size="100%">R Vasandhlakshmi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antiurolithiatic Potential of Methanolic Stem Extract of Spermacocce articularis L.f.: An In vitro and In vivo Approach</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">calcium oxalate</style></keyword><keyword><style  face="normal" font="default" size="100%">In vivo</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyethylene glycol</style></keyword><keyword><style  face="normal" font="default" size="100%">Spermacoce articularis</style></keyword><keyword><style  face="normal" font="default" size="100%">Urolithiasis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">770-778</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; Polygenic urolithiasis has a complicated etiology and even more varied therapeutic outcomes. &lt;em&gt;Spermacoce articularis&lt;/em&gt; L.f. has been used historically for stone treatments in several traditional medical systems. &lt;strong&gt;Aim:&lt;/strong&gt; The current study aimed to investigate the &lt;em&gt;in vitro&lt;/em&gt; and in vivo anti-urolithiatic potential of &lt;em&gt;Spermacoce articularis&lt;/em&gt; Stem Extract (SASE). &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;In vitro&lt;/em&gt; antiurolithiatic potential on the CaOx crystallization was evaluated using nucleation and aggregation assays. In vivo, activity was assessed on renal calculi-induced Wistar rats by polyethylene glycol (0.75%) in drinking water for 14 days. SASE and cystone with two experimental doses (250 and 500 mg/kg, p.o.) were dispensed for ten days. Various biochemical parameters were assessed in the kidneys' serum, urine, and histological sections. In addition, SASE inhibited CaOx crystallization by reducing the density of crystals, triggering the breakdown of CaOx crystals, and hindering their growth. Cystone demonstrated comparable outcomes. &lt;strong&gt;Results: &lt;/strong&gt;Upon treatment with SASE, urinary, serum, kidney homogenates, and antioxidants were significantly improved (p&amp;lt;0.05) to normal levels. The histopathology of the kidney section showed no damaged cells of SASE treated and Cystone treated compared with that of control animals. &lt;strong&gt;Conclusion: &lt;/strong&gt;This research validates the traditional idea and suggests that SASE is advantageous in preventing the growth of urinary stones.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">770</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;S Gopika, MK Nisha*, E Gaayathiri Devi, A Raja Rajeswari, R Vasandhlakshmi &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Botany,&amp;nbsp;Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore-43, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prasanth NV</style></author><author><style face="normal" font="default" size="100%">P Pandian</style></author><author><style face="normal" font="default" size="100%">T Balasubramanian</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of In Vivo Anti Alzheimer's Activity of Vigna radiata and Vigna pilosa using Beta Amyloid Induced Neurotoxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alzheimer’s disease</style></keyword><keyword><style  face="normal" font="default" size="100%">amyloid-β</style></keyword><keyword><style  face="normal" font="default" size="100%">Vigna pilosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Vigna radiata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">519-526</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;AD is the most common form of dementia. Extracellular senile (amyloid) plaques and intracellular neurofibrillary tangles (NFTs) are hallmarks of the disease. Vigna radiata and Vigna pilosa are plants used in many Ayurvedic formulations used in the management of dementia and related conditions. The present study was aimed to evaluate the neuroprotective effect of these plants on an amyloid-β (Aβ) 1-42 model of Alzheimer’s disease in rats. Duration of the study was 21 days. After the recovery period post Aβ1-42 ICV administration, from the 8thday, the ethyl acetate extract of Vigna radiata and ethanolic extract of Vigna pilosa (200mg/kg, 400mg/kg), Donepezil (3mg/kg) treatments were made once daily p.o till the 21st day. Cognitive behavioural studies were conducted using radial maze test, Step-through Passive Avoidance Test. The animals were further subjected to euthanasia and the brain were collected and evaluated for antioxidant parameters and brain cytokine levels. The brain tissues were subjected to histopathological examination. The treatment with the extracts significantly improved the cognitive capability of the rats in the Radial arm maze task and step through passive avoidance test. It also reduced oxidative stress, which was evident by the lower levels of lipid peroxide and nitric oxide as well as elevated levels of antioxidant enzymes like catalase, superoxide dismutase and reduced glutathione. The treatment alleviated neuroinflammation in rats by decreasing the concentration of neuroinflammatory markers in a dose-dependent manner. From the results it can be concluded that the plants Vigna radiata and Vigna pilosa has beneficial effects in the improvement of cognitive impairment AD, by reducing oxidative stress and neuroinflammation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">519</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prasanth NV&lt;sup&gt;1&lt;/sup&gt;*, P Pandian&lt;sup&gt;1&lt;/sup&gt;, T Balasubramanian&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;1Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;2Department of Pharmacology,Al Shifa College of Pharmacy, Perinthalmanna, Kerala, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Inbaraj Susai Domnic</style></author><author><style face="normal" font="default" size="100%">Prasanna Mohanabhaskaran</style></author><author><style face="normal" font="default" size="100%">Imran Zaheer</style></author><author><style face="normal" font="default" size="100%">Semmal Syed Meerasa</style></author><author><style face="normal" font="default" size="100%">Ramaprabha Prabhakar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Potential Toxicity Associated with Antidiabetic Herbs in Saudi Arabia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal medicines</style></keyword><keyword><style  face="normal" font="default" size="100%">KSA</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal herbs</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Saudi Arabia</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">576-581</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Diabetes mellitus is a serious, long-lasting disease that is characterized by high blood sugar levels, leading to more severe complications involving other organ systems of the body. Diabetes is becoming more common worldwide. Managing diabetes can be complicated, but many people, especially in Saudi Arabia, often use traditional herbal medicines to treat the condition. Our study concentrates on assessing the safety of commonly used antidiabetic herbs in Saudi Arabia by examining their potential toxicity. &lt;strong&gt;Method:&lt;/strong&gt; Using keywords and their variations, we conducted a systematic search of the PubMed and Google Scholar databases to find studies on treatments based on antidiabetic herbs and their toxic effects from 2014 to 2024. &lt;strong&gt;Result:&lt;/strong&gt; Our study revealed that the use of medicinal plants for treating and managing diabetes along with its complications is becoming popular around the globe. These medicinal plants are also being used as primary sources of developing modern pharmaceutical antidiabetic drugs. Phytotherapy is safe to treat diabetes as herbal bioactive components act through many biological pathways. They may inhibit α-glucosidase enzyme, enhance GLUT-4 translocation, and also improve lipid profile.&lt;strong&gt; Conclusion:&lt;/strong&gt; The use of natural plants having medicinal properties is popular for the treatment of diabetes. Claims of their usefulness by traditional healers are being supported by scientific evidence also. To determine the right dosage of these medicinal herbs, cytotoxicity tests or short-term experiments are done to establish doses of plants used in vitro and in vivo. Toxicity concerns are a primary reason why healthcare professionals hesitate to incorporate herbal products into the healthcare system. That’s why it is necessary to screen such plants for their toxicity to differentiate pharmacological efficacy from adverse effects.&amp;nbsp;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">576</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Inbaraj Susai Domnic*, Prasanna Mohanabhaskaran, Imran Zaheer, Semmal Syed Meerasa, Ramaprabha Prabhakar&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Basic Medical Sciences, College of Medicine- Dawadmi and Shaqra, Shaqra University, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Soma A. Mohammed</style></author><author><style face="normal" font="default" size="100%">Entedhar R. Sarhat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Serum Eta Protein, Sclerostin, and Calcitonin Level in Arthritis Patients on Vitamin D Therapy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Arthritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Calcitonin</style></keyword><keyword><style  face="normal" font="default" size="100%">ETA protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Sclerostin</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin D</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">426-430</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Arthritis is an inflammatory condition affecting the diarthrodial joints. A joint's bone, cartilage, and structural design all preserve its integrity, and arthritis alters that integrity, resulting in joint activity loss and discomfort. The primary symptom of arthritis is joint pain, although other symptoms include stiffness, inflammation, and impaired joint motor function. &lt;strong&gt;Methods:&lt;/strong&gt; The cross-sectional study comprised 90 subjects: 70 arthritis sufferers and 20 controls, ages 25-60, both sexes. From September 2023 to March 2024, patients were referred to Kirkuk city in Azadi hospital and Kirkuk general hospital. The research participants were placed into three groups: Group 1 for arthritic patients without Vit D (35). Patients with arthritis who received vitamin D for at least two months (G2), n (35), were the second group. The third group comprised healthy individuals without arthritis n (20). &lt;strong&gt;Result:&lt;/strong&gt; Significant (P&amp;lt;0.05) increase in ETA protein levels in G1 and G2 compared to G3. G1 had ETA protein levels of 28.05±5.34 ng/L, G2 had 24.10±3.67 ng/L, and G3 had 8.92±2.80 ng/L. Sclerostin levels peaked in G1 (0.4273±0.3023 pg/mL) and declined in G2 (P&amp;lt;0.05) compared to G3. Calcitonin levels were higher in G1 (34.72±4.72 pg/mL) and G2 (27.06±5.85 pg/mL) than G3 (14.71±3.71 pg/mL) at (P&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; The study found a rise in ETA protein and calcitonin levels in arthritic patients before and after therapy with vitamin D, which was not influenced by vitamin supplementation. Sclerostin levels increase in arthritic patients and decrease following therapy with vitamin D.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">426</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Soma A. Mohammed&lt;sup&gt;1&lt;/sup&gt;, Entedhar R. Sarhat&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;College of Medicine, Tikrit University, Tikrit, IRAQ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;College of Dentistry, Tikrit University, Tikrit, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Juana E. Chávez-Flores</style></author><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author><author><style face="normal" font="default" size="100%">Maria J. Abanto-Vaella</style></author><author><style face="normal" font="default" size="100%">César D. Gamarra-Sánchez</style></author><author><style face="normal" font="default" size="100%">Yuri F. Curo-Vallejos</style></author><author><style face="normal" font="default" size="100%">Marco L. Salazar-Castillo</style></author><author><style face="normal" font="default" size="100%">Icela M. Rodriguez-Haro</style></author><author><style face="normal" font="default" size="100%">Flor Soriano-López</style></author><author><style face="normal" font="default" size="100%">Renato Cueva- Veneros</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the Acute Toxicity of the Ethanolic Extract of the Rhizome of Zingiber officinale Roscoe in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity test</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Zingiber officinale</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">323-331</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ginger has pharmacological activities such as anticancer, antidiabetic, antioxidant, antimicrobial, anti-neuroinflammatory, and chemotherapy-induced nausea and vomiting. &lt;strong&gt;Objective:&lt;/strong&gt; The research aims to evaluate the acute toxicity of the ethanolic extract of the rhizome of Zingiber officinale Roscoe in rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The extract was administrated at doses of 300 and 2000 mg/ Kg/day to female and male rats. Changes in body weight were determined during the 14-day treatment period, and on the last day of treatment, blood was drawn, and euthanasia was performed, removing organs for histological analysis. Biochemical parameters were measured. &lt;strong&gt;Results:&lt;/strong&gt; The body weight of the research specimens not show statistically significant variation. In the liver, mild lymphocytic portal inflammation and moderate hepatic steatosis occurred at doses of 2000 mg/kg/day. The kidneys exhibited a mild infiltration around the renal tubules and glomeruli at the same dose. The brain showed a slight increase in the count of astrocytes with focal glial reaction at the highest dose. The stomach and heart also showed mild inflammatory processes at the dose of 2000 mg/kg/day. In biochemical parameters, statistically significant differences were observed between the dose of 2000 mg/Kg/day and the control group. &lt;strong&gt;Conclusion: &lt;/strong&gt;The ethanolic extract of the rhizome of Z. officinale in rats revealed histopathological changes in the liver, kidneys, brain, stomach, and heart, besides changes in biochemical parameters at doses of 2000 mg/Kg/day.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">323</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Víctor E. Villarreal-La Torre&lt;sup&gt;1&lt;/sup&gt;, Juana E. Chávez-Flores&lt;sup&gt;2&lt;/sup&gt;, Carmen R. Silva-Correa&lt;sup&gt;1,*&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;3&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;3&lt;/sup&gt;, Julio Hilario- Vargas&lt;sup&gt;4&lt;/sup&gt;, Maria J. Abanto-Vaella&lt;sup&gt;4&lt;/sup&gt;, César D. Gamarra-Sánchez&lt;sup&gt;1&lt;/sup&gt;, Yuri F. Curo-Vallejos&lt;sup&gt;1&lt;/sup&gt;, Marco L. Salazar-Castillo&lt;sup&gt;3&lt;/sup&gt;, Icela M. Rodriguez- Haro&lt;sup&gt;3&lt;/sup&gt;, Flor Soriano-López&lt;sup&gt;3&lt;/sup&gt;, Renato Cueva-Veneros&lt;sup&gt;5&lt;/sup&gt;, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Universidad Nacional de Frontera, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dewi Sartika</style></author><author><style face="normal" font="default" size="100%">Amran Razak</style></author><author><style face="normal" font="default" size="100%">Muhammad Alwy Arifin</style></author><author><style face="normal" font="default" size="100%">Balqis</style></author><author><style face="normal" font="default" size="100%">Muhammad Kardi</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the Antenatal Care Service Program at the Tojo Una-Una District Health Office</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antenatal Care Services</style></keyword><keyword><style  face="normal" font="default" size="100%">Health Service</style></keyword><keyword><style  face="normal" font="default" size="100%">Program Evaluation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">615-623</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Through ANC, various information and education related to pregnancy and childbirth preparation can be provided to mothers as early as possible. ANC service is a program provided to pregnant women as a form of preventive service for disorders during pregnancy and also functions as an early detection of health problems experienced by pregnant women. Objective: This research is to evaluate the antenatal care service program in Tojo Una-una Regency based on Input, Process and Output. Method: This type of research uses a qualitative research design through in-depth interview techniques and document reviews. Determining informants using purposive sampling technique, numbering 11 informants. Data were collected through triangulation techniques, namely in-depth interviews, observation and documentation using interview guides. Results: research shows that the input to the antenatal care service program in terms of funding used for the ANC service program is still insufficient where the funds come from APBN funds in the form of non-physical DAK, BOK and BPJS funds, apart from that the availability of human resources is still inadequate, Some community health centers still feel inadequate because they have a large working area, making it difficult to carry out activities in the field or at the community health center because the village midwife, who is supposed to only work at the village health post, has concurrent duties at the community health center. In the process component, the community health center has implemented the antenatal care service program in accordance with the plan, although there are still several obstacles such as funding problems during the activity, problems with supervision being carried out by the health service only once a year and while the output is achieving coverage of the antenatal care service program in The Tojo Una Regency Health Service still has not met the target coverage that has been set due to the lack of optimal input and processes in the antenatal care service program system both at the health service and at the community health center. Conclusion: The evaluation at the Tojo Una-una District Health Service in 2023 is still not going well because the input is still inadequate, the process is still not carried out optimally so that the output to achieve program coverage still does not meet the target coverage that has been set.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">615</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Dewi Sartika&lt;sup&gt;1&lt;/sup&gt;*, Amran Razak&lt;sup&gt;2&lt;/sup&gt;, Muhammad Alwy Arifin&lt;sup&gt;3&lt;/sup&gt;,Balqis&lt;sup&gt;4&lt;/sup&gt;, Muhammad Kardi&lt;sup&gt;5&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;6&lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Masters Student of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of nutritional sciences, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Armiaty Octavia</style></author><author><style face="normal" font="default" size="100%">Muhammad Alwy Arifin</style></author><author><style face="normal" font="default" size="100%">Indar</style></author><author><style face="normal" font="default" size="100%">Darmawansyah</style></author><author><style face="normal" font="default" size="100%">M. Furqaan Naiem</style></author><author><style face="normal" font="default" size="100%">Ida Leida</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the Program to Overcome Undernutrition in the Working Area of Cendrawasih City Health Center, Makassar</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">Malnutrition.</style></keyword><keyword><style  face="normal" font="default" size="100%">Program</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">880-887</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Poor or insufficient nutrition can have serious impacts, especially on vulnerable groups such as toddlers, pregnant women and the elderly. Malnutrition not only has a direct impact on physical health conditions, but can also hinder optimal growth and development, both physically and mentally. &lt;strong&gt;Objective:&lt;/strong&gt; The aim of this study to evaluate the implementation of the malnutrition prevention program in the Cendrawasih Health Center work area, Makassar City in 2023. &lt;strong&gt;Method: &lt;/strong&gt;This type of research is qualitative research. The samples for this research are community health center staff, stakeholders and program users. Results: Evaluation of the malnutrition prevention program in the Cendrawasih Health Center working area, Makassar City is based on Context, &lt;em&gt;Input, Process &lt;/em&gt;and Product analysis. The research results show that in terms of social and cultural conditions, some communities pay less attention to children's nutrition. &lt;em&gt;Input &lt;/em&gt;is in the form of funds used, namely BOK funds and funds from the local government. Apart from that, the availability of human resources is inadequate. The facilities and infrastructure used are quite complete with the availability of anthropometric tools. Process Growth monitoring is carried out by community health center officers and posyandu cadres every 10 days. &lt;em&gt;Product&lt;/em&gt; The nutritional status of toddlers is starting to improve, this is proven by the number of cases which has decreased. Mothers' knowledge about the characteristics or signs that children are experiencing malnutrition is still lacking. Apart from that, mothers still don't fully understand parenting patterns for toddlers. &lt;strong&gt;Conclusion:&lt;/strong&gt; The evaluation of the malnutrition prevention program at the Cendrawasih Community Health Center in 2023 is still not going well because the &lt;em&gt;input&lt;/em&gt; is not adequate, the process has not been carried out optimally so that the &lt;em&gt;product&lt;/em&gt; produced does not meet the achievement targets. Efforts that can be made include active cadres in socializing children's nutrition. Apart from that, counseling efforts regarding malnutrition among pregnant women also continue to be increased.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">880</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Armiaty Octavia&lt;sup&gt;1*&lt;/sup&gt;, Muhammad Alwy Arifin&lt;sup&gt;2&lt;/sup&gt;, Indar&lt;sup&gt;2&lt;/sup&gt;, Darmawansyah&lt;sup&gt;2&lt;/sup&gt;, M. Furqaan Naiem&lt;sup&gt;3&lt;/sup&gt;, Ida Leida&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Masters Student of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health,&amp;nbsp;Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health,&amp;nbsp;Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health,&amp;nbsp;Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haider Nasser Jabber</style></author><author><style face="normal" font="default" size="100%">Bassem Charfeddine</style></author><author><style face="normal" font="default" size="100%">Hamed Jaddoa Abbas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Tumor Necrosis Factor Alpha, Insulin, glucose, HbA1c% and HOMA-IR as Predictors for Cardiovascular Diseases in Patients with Type 2 Diabetes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cardiovascular Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes Mellitus and Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">HOMA-IR</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin</style></keyword><keyword><style  face="normal" font="default" size="100%">TNFα</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">195-201</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Comparison of the blood level of TNFα in patients with and without type 2 diabetes who have cardiovascular diseases. Examine the connection between the amount of serum TNFα and insulin resistance in patients with type 2 diabetes who have cardiovascular diseases. &lt;strong&gt;Method:&lt;/strong&gt; The present study included 60 patients with Diabetes Mellitus (DM) with a mean age of 56.02±1.395 years and an age range of (40 - 80)years and 60 patients with cardiovascular diseases and diabetes (CVD and DM) with a mean age of 59.20±1.478 and an age range of (40-80) years, Who visited Al-Basrah Teaching Hospital in Basrah. in addition, the study included 60 healthy controls mean age of healthy control subjects was 54.72±1.405years. All patients in this study were diagnosed by specialized doctors and the diagnosis was verified by clinical and laboratory tests, during the period from September 2022 to September 2023. All Subjects signed a written informed consent form. The BMI was calculated as body weight (kg) and was divided by squared height in meters. &lt;strong&gt;Results:&lt;/strong&gt; The results of this study showed an increase in the level of glucose, haemoglobin A1c%, insulin, and HOMA IR (in CVD and DM patients as compared with DM patients and control and there was a significant difference in concentrations among study groups (p-value &amp;lt;0.0001). Also, The results of this study showed an increase in the level of tumor necrosis factor-alpha in CVD and DM patients as compared with DM and control and there was a significant difference in concentrations of TNFα among study groups (p-value &amp;lt;0.0001). &lt;strong&gt;Conclusion: &lt;/strong&gt;Based on the findings of this research, it can be inferred that TNFα and HbA1c have the potential to serve as practical and straightforward indicators for predicting the coexistence of insulin resistance, dysglycemia, and Cardiovascular Diseases in seemingly healthy individuals within the young (&amp;lt;50 years) Al-Basra community.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">195</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Haider Nasser Jabber&lt;sup&gt;1,2,&lt;/sup&gt;*, Bassem Charfeddine&lt;sup&gt;2&lt;/sup&gt;, Hamed Jaddoa Abbas&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;College of Pharmacy, Basra University, Basrah, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, University of Sousse, TUNISIA. 3Al-Fayhaa Teaching Hospital – Al- Zahraa Medical college- Basrah University, Basrah, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rusli Taher</style></author><author><style face="normal" font="default" size="100%">H. Muh. Syafar</style></author><author><style face="normal" font="default" size="100%">A. Indahwaty Sidin</style></author><author><style face="normal" font="default" size="100%">Stang</style></author><author><style face="normal" font="default" size="100%">Oedojo Soedirman</style></author><author><style face="normal" font="default" size="100%">Syamsiar S. Russeng</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Andi Armyn Nurdin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Exploration of Adolescent Knowledge Experiences and Efforts to Identify Interventions on the Use of Digital Technology Information Media to Increase Knowledge related to HIV/AIDS Prevention</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HIV/AIDS</style></keyword><keyword><style  face="normal" font="default" size="100%">Intervention Strategy</style></keyword><keyword><style  face="normal" font="default" size="100%">knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Model Development</style></keyword><keyword><style  face="normal" font="default" size="100%">Youth</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1150-1158</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;HIV/AIDS has become a pandemic that worries the world community, especially teenagers because of their lack of understanding in tackling the prevention and spread of HIV/AIDS. One of the things that can be done is to identify interventions in the utilization of digital technology information media. &lt;strong&gt;Purpose:&lt;/strong&gt; This study focuses on exploring the experiences of adolescents in efforts and in identifying interventions using digital technology information media to increase knowledge related to HIV/AIDS prevention.&lt;strong&gt; Methods:&lt;/strong&gt; Qualitative research using interpretive descriptive approach and literature review on teenage students of SMA Negeri 4 (SMA A) and SMK Negeri 6 (SMA B) in Pangkep Regency, Class II and Class III. Sampling using t purposive sampling type of criteria sampling. The number of participants is 20 people and 5 participants who fall into the source triangulation category. Semi-structured interview guidelines with in-depth interviews, FGDs and observations using field notes. &lt;strong&gt;Results: &lt;/strong&gt;There are 4 main themes that are obtained, namely: 1) Lack of youth knowledge about HIV/AIDS; 2) Perception of adolescents' response control towards HIV/AIDS sufferers (ODHA); 3) Work Program in efforts to prevent HIV/AIDS; 4) The needs of adolescents, teachers, health center staff, and the health office regarding plans for developing interventions to increase youth knowledge in efforts to prevent HIV/AIDS. &lt;strong&gt;Conclusion: &lt;/strong&gt;Respondents have inadequate knowledge about HIV/AIDS, show negative attitudes towards PLHIV and are also involved in risky practices that can affect HIV transmission. This shows that the provision of accurate and comprehensive information related to HIV/ AIDS is a component of prevention and control interventions that must be increased so that intervention strategies are needed to alleviate suffering and possibly reduce the negative consequences that may occur.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rusli Taher&lt;sup&gt;1,2*&lt;/sup&gt;, H. Muh. Syafar&lt;sup&gt;3&lt;/sup&gt;, A. Indahwaty Sidin&lt;sup&gt;4&lt;/sup&gt;, Stang&lt;sup&gt;5&lt;/sup&gt;, Oedojo Soedirman&lt;sup&gt;6&lt;/sup&gt;, Syamsiar S. Russeng&lt;sup&gt;7&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;8&lt;/sup&gt; , Andi Armyn Nurdin&lt;sup&gt;9&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;10&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Public Health Doctoral Student, Public Health Study Program, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Lecturer in the Nursing Profession Study Program, STIKES Graha Edukasi Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Promoters and Professors of the Department of Health Promotion and Behavioral Sciences, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Lecturers in the Department of Hospital Management, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor of the Department of Biostatistics, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Lecturers of the Department of Health Promotion and Behavioral Sciences FKM UNAIR, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Professor of the Department of Occupational Safety and Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Professor of the Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Lecturers at the Faculty of Medicine, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Professor, Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">K Swathi Priya</style></author><author><style face="normal" font="default" size="100%">Rajasekaran S</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Exploring the Bioactive Potential of Marine Algae: Insights from Phytochemical Analysis, GC-MS Profiling, and Antioxidant Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">GCMS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Spongomorpha indica</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">336-341</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;While there has been a lot of research on novel compounds derived from natural sources, there is now considerably greater opportunity for study when it comes to marine sources. The immense wealth concealed in marine sources was less known in the past because of a lack of technology. The most recent technological advancements have made gathering and researching marine sources simple. Highly bioactive secondary metabolites that may aid in the development of novel pharmacological drugs are found in marine creatures. The two primary categories of marine algae are macroalgae and microalgae. While macroalgae, also referred to as seaweed, are classified into green, brown, and red algae, microalgae comprise blue-green algae, bacillariophyte, and dinoflagellates. &lt;strong&gt;Material and methods:&lt;/strong&gt; Spongomorpha indica, a green macroalga, has been chosen for this study, and its physicochemical parameters, phytochemical analysis, GC-MS analysis, and antioxidant activity have all been examined. The purpose of this study was to determine whether more research on this seaweed's potential benefits for medical purposes is necessary. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical tests indicated the presence of potent active constituents like alkaloids, steroids, tannins, and flavonoids; as a result, the study was further extended to GCMS analysis, where seven components were identified, the highest peak and molecular weight of which are all in accordance with WHO guidelines. The physicochemical parameter results were also in line with WHO guidelines. Ultimately, antioxidant activity was assessed using four distinct models, and all results demonstrated a significant amount of antioxidant activity, with superoxide scavenging activity demonstrating the best results.&lt;strong&gt; Conclusion:&lt;/strong&gt; Based on the results, it was determined that Spongomorpha indica contains potent active ingredients with significant antioxidant effects. As a result, the study is now being conducted to examine target-related activity to determine the most efficient way to cure a specific condition.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">336</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;K Swathi Priya*, Rajasekaran S&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Bhagwant University, Sikar Rd, Ajmer, Rajasthan, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Taniht Lisseth Cubas Romero</style></author><author><style face="normal" font="default" size="100%">Santiago M. Benites</style></author><author><style face="normal" font="default" size="100%">Anthony Derlis Auris-López</style></author><author><style face="normal" font="default" size="100%">Gerardo Manuel Del Pino-Aliaga</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Exploring the Calming Potential of Peppermint: Anxiolytic Effects of Mentha piperita Essential Oil on State and Trait Anxiety</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Mentha piperita</style></keyword><keyword><style  face="normal" font="default" size="100%">State anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Trait anxiety</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1290-1296</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This study aimed to evaluate the anxiolytic effect of &lt;em&gt;Mentha piperita&lt;/em&gt; essential oil on state and trait anxiety. &lt;strong&gt;Methods:&lt;/strong&gt; The essential oil was extracted by hydrodistillation, and its chemical composition was analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). A total of 93 participants were divided into a control group (CG) and an experimental group (EG), with 47 participants in the EG receiving MPEO aromatherapy and 46 in the CG. Anxiety levels were measured using the State-Trait Anxiety Inventory (STAI) at pretest and posttest phases. Results: GC-MS analysis showed that menthol had the highest concentration (42.56%), followed by menthone (19.24%) and linalool (11.68%). Mixed model analysis revealed that group assignment (EG vs. CG) was a significant predictor of posttest state anxiety (F=16.508, p=0.001) and trait anxiety (F=9.091, p=0.003), independent of pretest scores, supporting the intervention’s effect on reducing anxiety. Posttest results showed a significant reduction in state anxiety in the EG compared to the CG (p=0.001) with a large effect size (r=0.508), while trait anxiety showed a moderate reduction (p=0.001, r=0.342).&lt;strong&gt; Conclusion: &lt;/strong&gt;These findings suggest that &lt;em&gt;Mentha piperita&lt;/em&gt; essential oil may effectively reduce state and trait anxiety, with a more pronounced impact on state anxiety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1290</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado- García&lt;sup&gt;1&lt;/sup&gt;, Marilú Roxana Soto- Vásquez&lt;sup&gt;2&lt;/sup&gt;, Taniht Lisseth Cubas Romero&lt;sup&gt;1&lt;/sup&gt;, Santiago M. Benites&lt;sup&gt;3&lt;/sup&gt;, Anthony Derlis Auris-López&lt;sup&gt;1&lt;/sup&gt;, Gerardo Manuel Del Pino- Aliaga&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Psicología. Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dian Mayangsari</style></author><author><style face="normal" font="default" size="100%">Lukisiari Agustini</style></author><author><style face="normal" font="default" size="100%">Susy Fatmariyanti</style></author><author><style face="normal" font="default" size="100%">Ridholia</style></author><author><style face="normal" font="default" size="100%">Pudji Lestari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Expression of Matrix Metalloproteinase-9, Transforming Growth Factor Beta and Fibroblast in The Simblefaron Due to Alkali Burn: Literature Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkali</style></keyword><keyword><style  face="normal" font="default" size="100%">Burn</style></keyword><keyword><style  face="normal" font="default" size="100%">Conjunctiva</style></keyword><keyword><style  face="normal" font="default" size="100%">Symblepharon</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">687-690</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Simblefaron is one of the most challenging complications in the late stages of an alkali burn. Symblepharon characteristically resembles connective tissue or bands that protrude from the eyelid's interior surface (palpebral conjunctiva) to the surface of the eyeball (bulbar conjunctiva). This literature review was conducted to see the molecular mechanism of symblepharon formation. Matrix metalloproteinase (MMP- 9), transforming growth factor (TGF-β), and Fibroblast played a significant part in the healing of conjunctival wounds. MMP-9, TGF-β, and fibroblast overexpressed are suspected to cause excessive inflammation and fibrosis, which results in symblepharon. By knowing this, it is hoped that it can become a basis for developing appropriate management for the occurrence of simblepharon.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">687-690</style></work-type><section><style face="normal" font="default" size="100%">687</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;Dian Mayangsari&lt;sup&gt;1&lt;/sup&gt;*, Lukisiari Agustini&lt;sup&gt;1&lt;/sup&gt;, Susy Fatmariyanti&lt;sup&gt;1&lt;/sup&gt;, Ridholia&lt;sup&gt;2&lt;/sup&gt;, Pudji Lestari&lt;sup&gt;3&lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Ophthalmology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of IKM-KP, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jesús Rojas-Jaimes</style></author><author><style face="normal" font="default" size="100%">Marco Mesía-Guevara</style></author><author><style face="normal" font="default" size="100%">Alexander Murillo-Zenozain</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Butionin-Sulfaximine and Fluphenazine as Trypanothione Inhibitory Drugs on Promastigotes and Axenic Amastigotes of Leishmania Peruviana and Leishmania Braziliensis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Axenic Amastigote</style></keyword><keyword><style  face="normal" font="default" size="100%">Butionin-Sulfaximine</style></keyword><keyword><style  face="normal" font="default" size="100%">Fluphenazine</style></keyword><keyword><style  face="normal" font="default" size="100%">Leishmania</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">82-85</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Leishmaniasis is a disease caused by the &lt;em&gt;Leishmania parasite&lt;/em&gt;, which is difficult to diagnose, causes disfigurement and is difficult to treat. Objectives: To determine the effect of Butionin-Sulfaximine (BSO) and Fluphenazine on trypomastigotes and axenic amastigotes of &lt;em&gt;Leishmania peruviana&lt;/em&gt; and &lt;em&gt;Leishmania braziliensis&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; A study was performed with Butionin-Sulfaximine (BSO), Fluphenazine, and Glucantime (positive control,) utilizing respective concentrations of 41.7 mg/ml, 4.17 mg/ml, and 50 mg/ml for twenty-four hours on axenic amastigotes. &lt;strong&gt;Results:&lt;/strong&gt; A significant difference (*P &amp;lt; 0.05) was found between the negative control group, Fluphenazine, and BSO within both the axenic amastigotes of L. peruviana (5.5 X 10&lt;sup&gt;5&lt;/sup&gt; / ml for the negative control, 0.15 X 10&lt;sup&gt;5&lt;/sup&gt; / ml for Fluphenazine, and 0.7 X 10&lt;sup&gt;5&lt;/sup&gt; / ml for BSO) and &lt;em&gt;L. braziliensis &lt;/em&gt;(6.9 X 10&lt;sup&gt;5&lt;/sup&gt;/ml for the negative control, 0.18 X 10&lt;sup&gt;5&lt;/sup&gt;/ml for Fluphenazine, and 0.22 X 10&lt;sup&gt;5&lt;/sup&gt;/ml for BSO). Another significant difference (*P &amp;lt; 0.05) was found in the promastigotes of L. peruviana (5.9 X 10&lt;sup&gt;5&lt;/sup&gt; / ml for the negative control, 0.66 X 10&lt;sup&gt;5 &lt;/sup&gt;/ ml for Fluphenazine, and 3.1 X 10&lt;sup&gt;5&lt;/sup&gt; / ml for BSO) and L. braziliensis (8.7 X 10&lt;sup&gt;5&lt;/sup&gt;/ml for the negative control and 5.68 X 10&lt;sup&gt;5&lt;/sup&gt;/ml for Fluphenazine). &lt;strong&gt;Conclusions: &lt;/strong&gt;From this, we conclude Fluphenazine and BSO present promising antiparasitic effects against axenic amastigotes of L. peruviana and L. braziliensis in both pharmacological tests of the in vivo model and their potential future use.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">82</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jesús Rojas-Jaimes&lt;sup&gt;1,2,*&lt;/sup&gt;, Marco Mesia-Guevara&lt;sup&gt;1&lt;/sup&gt;, Alexander Murillo- Zenozain&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;College of Human Medicine, Universidad Científica del Sur, Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Health Sciences Faculty, Universidad Privada del Norte, Lima, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muqiemuddin Salim</style></author><author><style face="normal" font="default" size="100%">I Ketut Alit Utamayasa</style></author><author><style face="normal" font="default" size="100%">Roedi Irawan</style></author><author><style face="normal" font="default" size="100%">Irwanto</style></author><author><style face="normal" font="default" size="100%">Azwin Mengindra Putera</style></author><author><style face="normal" font="default" size="100%">Meity Ardiana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Cardiac Catheterization Intervention on The Nutritional Status of Children with Acyanotic Congenital Heart Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acyanotic CHD</style></keyword><keyword><style  face="normal" font="default" size="100%">Children</style></keyword><keyword><style  face="normal" font="default" size="100%">Congenital heart disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Interventional cardiac catheterization.</style></keyword><keyword><style  face="normal" font="default" size="100%">Nutritional status</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">338-342</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Intervention is required since malnutrition in children with acyanotic congenital heart disease (CHD) will affect growth, development, and quality of life. Research on the impact of cardiac catheterization on the nutritional health of children with acyanotic CHD is limited, particularly in Indonesia. This study aims to analyze the effect of cardiac catheterization on the nutritional status of children with acyanotic CHD. &lt;strong&gt;Methods: &lt;/strong&gt;A cross-sectional study was conducted between January 2019 and December 2021. The participants of this study were children aged 1-60 months with acyanotic CHD who had undergone cardiac catheterization. We compare the nutritional status of participants in three observation stages, including pre-intervention of catheterization and the 3rd and 6th months post-cardiac catheterization. The parameters of nutritional status are determined according to the mean of Z-scores of weight-for-age (WAZ), length-for-age (LAZ), and weight-for-length (WLZ) of participants. &lt;strong&gt;Results: &lt;/strong&gt;A total of children with acyanotic CHD who underwent catheterization and 49 children were eligible participants. The mean age of children with acyanotic CHD patients who underwent catheterization was 31.51 months, and 89% of them were 1-5 years. Fifty-three percent of participants who underwent cardiac catheterization were male. The most common acyanotic CHD defects were the Patent Ductus Arteriosus (PDA) among 55.1% of participants. Significant differences were found in WAZ, LAZ, and WLZ in the measurement of three observation stages (p&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Interventional cardiac catheterization affects and enhances the nutritional status of children with acyanotic CHD and may be suggested as an initial therapy to further evaluate the disease.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">338</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muqiemuddin Salim&lt;sup&gt;1&lt;/sup&gt;, I Ketut Alit Utamayasa&lt;sup&gt;1,*&lt;/sup&gt;, Roedi Irawan&lt;sup&gt;1&lt;/sup&gt;, Irwanto&lt;sup&gt;1&lt;/sup&gt;, Azwin Mengindra Putera&lt;sup&gt;1&lt;/sup&gt;, Meity Ardiana&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Child Health, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wachid Putranto</style></author><author><style face="normal" font="default" size="100%">Septina Hestiningrum</style></author><author><style face="normal" font="default" size="100%">Nur Ismi Mustika Febriani</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Ratih Tri Kusuma Dewi</style></author><author><style face="normal" font="default" size="100%">Santy Ayu Puspita Perdhana</style></author><author><style face="normal" font="default" size="100%">Nurhasan Agung Prabowo</style></author><author><style face="normal" font="default" size="100%">Yeremia Suryo Pratama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Channa striata Extract on Serum Albumin and High Sensitive C-Reactive Protein in End-Stage Renal Disease Patients: A Randomized Controlled Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Channa striata</style></keyword><keyword><style  face="normal" font="default" size="100%">End-stage renal disease</style></keyword><keyword><style  face="normal" font="default" size="100%">hs-CRP</style></keyword><keyword><style  face="normal" font="default" size="100%">Supplementation.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1-5</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Albumin is a marker of nutritioinal inflammation and mortality. Chronic inflammation, as indicated by the concentration of a proinflammatory cytokine, high sensitivity C-reactive protein (hs-CRP) was reported to be high in end-stage renal disease (ESRD) patients. &lt;em&gt;Channa striata&lt;/em&gt; (CS) contains high protein that can increase albumin levels and has anti-inflammatory effects. This study was conducted to determine the effect of CS extract on serum albumin and hs-CRP on ESRD patients. &lt;strong&gt;Methods: &lt;/strong&gt;This study is a randomized, double blind, placebo-controlled study in patients with ESRD on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD). Subjects were randomized to either a CS or a placebo group and were given a three times daily dosage of 500 mg of CS extract or 500 mg maltodextrin, respectively for 21 days. Serum albumin and hs-CRP were measured at the baseline, and at the end of the study. &lt;strong&gt;Result: &lt;/strong&gt;Forty subjects were randomized into the study with 20 in the &lt;em&gt;Channa striata &lt;/em&gt;group and 20 in the placebo group, with HD and CAPD patient evenly distributed among the group. Significant increase in serum albumin levels (p&amp;lt;0,001) and significant decrease of hs-CRP (p&amp;lt;0,001) were observed in the treatment group compared to control group at the end of the study. At the end of the study, there was no significant difference between serum albumin, hs-CRP, and their gradient between HD and CAPD patients in the intervention group. &lt;strong&gt;Conclusion: &lt;/strong&gt;CS extract results in higher serum albumin and lower hs-CRP levels compared to placebo in our population.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Wachid Putranto&lt;sup&gt;1,2,*&lt;/sup&gt;, Septina Hestiningrum&lt;sup&gt;1,2&lt;/sup&gt;, Nur Ismi Mustika Febriani&lt;sup&gt;1,2&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;3&lt;/sup&gt;, Ratih Tri Kusuma Dewi&lt;sup&gt;1,2&lt;/sup&gt;, Santy Ayu Puspita Perdhana&lt;sup&gt;1,2&lt;/sup&gt;, Nurhasan Agung Prabowo&lt;sup&gt;2,4&lt;/sup&gt;, Yeremia Suryo Pratama&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Nephrology, Department of Internal Medicine, Dr. Moewardi General Hospital, Faculty of Medicine, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Sebelas Maret University, Surakarta, Jl. Ir. Sutami 36, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anatomic Pathology, Doctoral Programme Study of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Drug Development Research Cluster, Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Sebelas Maret University Hospital, Jl. A. Yani 200, Sukoharjo, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Novi Primadewi</style></author><author><style face="normal" font="default" size="100%">Harijono Kariosentono</style></author><author><style face="normal" font="default" size="100%">Ari Probandari</style></author><author><style face="normal" font="default" size="100%">Budiyanti Wiboworini</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Combination between Green Tea Extract and Curcumin Extract from Mt. Lawu on BAX, Bcl-2 and Caspase-3 in Cisplatin-Induced Rat Models</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiapoptotic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ototoxicity.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">370-374</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The study determines effect of Combination between Green Tea and Curcumin Extract from Mount Lawu on BAX, Bcl-2 and Caspase-3 in Cisplatin (Cis)-induced rat models. &lt;strong&gt;Methods:&lt;/strong&gt; We treated four rats in each group and randomly distributed them into four groups: group C (−) was the negative control group with no treatment given, group C (+) was the positive control group given Cis only, group A1 was given green tea extract and curcumin extract combination after Cis, and group A2 was given Ginkgo biloba after Cis. Expression levels of BAX, Bcl-2, and Caspase-3 were assessed by ELISA. An ANOVA, a parametric test, was used if the data were normally distributed. If there were significant differences between the three groups regarding BAX, Bcl-2 and Caspase-3, a post hoc test was performed to determine the differences between treatments.&lt;strong&gt; Results:&lt;/strong&gt; The results of the study show that combination between green tea and curcumin extract can increase Bcl-2 levels with an average value of 15.42 + 0.76 ng/mL, better than Ginkgo biloba extract with a value of 13.50 + 0.47 ng/mL, reduce BAX and Caspase-3 levels with a value of 6.57 + 0.38 ng/mL and 2.89 + 0.19 ng/mL, better than Ginkgo biloba with a value of 7.34 + 1.06 ng/mL and 3.86 + 0.34 ng/mL. &lt;strong&gt;Conclusion: &lt;/strong&gt;This research shows that Combination between Green Tea and Curcumin Extract can increase Bcl-2 levels and reduce BAX and Caspase-3 in Cis rat models after fourteen days of treatment, better than Ginkgo biloba.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">370</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Novi Primadewi&lt;sup&gt;1,*&lt;/sup&gt;, Harijono Kariosentono&lt;sup&gt;2&lt;/sup&gt;, Ari Probandari&lt;sup&gt;3&lt;/sup&gt;, Budiyanti Wiboworini&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Science Doctoral Study Program, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department Dermatovenereology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department Public Health, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Nutrition Sciences, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sumarawati T</style></author><author><style face="normal" font="default" size="100%">Chodidjah</style></author><author><style face="normal" font="default" size="100%">Dina Fatmawati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Combination of Soybean and Phaleria macrocarpa Ethanol Extract on IL6, TNFα, VEGF and Fibroblasts in Mice Exposed to UVB</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin wound</style></keyword><keyword><style  face="normal" font="default" size="100%">UV B radiation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">6-13</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;UV exposure causes inflammation and the generation of reactive oxygen species, both of which contribute to skin aging. The purpose of this research was to determine how a combination of &lt;em&gt;Phaleria macrocarpa &lt;/em&gt;extract and soybean extract affected the number of fibroblasts, VEGF, IL-6, and TNF alpha expression, and blood levels of IL-6 and TNF alpha in UV-B-exposed mice. In this study, mice were placed into four groups: one control group, three treatment groups, and a combination of &lt;em&gt;Phaleria macrocarpa&lt;/em&gt;:soybeans at a 1:1 ratio (com group). The mice were euthanized on days 5 and 21 for histological preparations and then examined under a light microscope. Using an Olympus C-21 microscope with an Optilab Advances camera at 1000x magnification, the fibroblast was studied by counting the number of fibroblast cells per field of view. The immunohistochemical approach was performed to analyze the expression of VEGF, IL-6, and TNF- in skin tissue. The ELISA technique was used to quantify the levels of IL-6 and TNF-alpha. SPSS ver 21 was used to analyze the data. On days 5 and 21, the number of fibroblasts and expression of VEGF, IL-6, and TNF alpha were significantly higher in the combination group than in the control, &lt;em&gt;Phaleria macrocarpa&lt;/em&gt;, and soybean treatment groups. However, there was no significant change in IL-6 and TNF alpha levels across groups on days 5 and 21 (p &amp;gt; 0.05). Finally, a 1:1 mixture of &lt;em&gt;Phaleria macrocarpa&lt;/em&gt; and soybeans reduced the number of fibroblasts and the production of VEGF, IL-6, and TNF alpha on days 5 and 21, but not in serum levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">6</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sumarawati T&lt;sup&gt;1,*&lt;/sup&gt;, Chodidjah&lt;sup&gt;2&lt;/sup&gt;, Dina Fatmawati&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Medicine, Universitas Islam Sultan Agung, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomi, Faculty of Medicine, Universitas Islam Sultan Agung&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Medicine, Universitas Islam Sultan Agung, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dinar Sari C. Wahyuni</style></author><author><style face="normal" font="default" size="100%">Siti A. E. Astuti</style></author><author><style face="normal" font="default" size="100%">Soerya Dewi Marliyana</style></author><author><style face="normal" font="default" size="100%">Yudi Rinanto</style></author><author><style face="normal" font="default" size="100%">Tiara Dewi S. Pratama</style></author><author><style face="normal" font="default" size="100%">Ahmad Fauzi</style></author><author><style face="normal" font="default" size="100%">Ari Satia Nugraha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Drying Methods on Chemical Profiling of Zingiberaceae Herbs Production</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Curcuma Genus</style></keyword><keyword><style  face="normal" font="default" size="100%">Freeze drying</style></keyword><keyword><style  face="normal" font="default" size="100%">Multivariate</style></keyword><keyword><style  face="normal" font="default" size="100%">Oven drying</style></keyword><keyword><style  face="normal" font="default" size="100%">Zingiber Genus.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">128-133</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Drying method is one of the important steps in post-harvesting in herbal production in order to prolong the shelf-life of herbal medicine and to ensure the good quality. &lt;strong&gt;Objective&lt;/strong&gt;: This research aimed to profile and quantify the metabolites changing using metabolomic based on&lt;sup&gt; 1&lt;/sup&gt;H-NMR Spectroscopy on &lt;em&gt;Curcuma and Zingiber&lt;/em&gt; genus due to the drying process. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Five species of the &lt;em&gt;Curcuma and Zingiber &lt;/em&gt;genus were Curcuma longa &lt;em&gt;L., Curcuma&lt;/em&gt; aeruginosa Roxb., Curcuma xanthorrhiza Roxb., Zingiber officinale Roscoe. and Zingiber amaricans BI. The drying method applied were freeze drying and oven drying method at -1080C and 500C, respectively. Samples were extracted using buffer phosphate and deuterated methanol (3:7). The analysis was performed using &lt;sup&gt;1&lt;/sup&gt;H-NMR spectroscopy 400 MHz with TSP as an internal standard. The &lt;sup&gt;1&lt;/sup&gt;H-NMR spectra were analysed with multivariate (Principal Component Analysis).&lt;strong&gt; Results:&lt;/strong&gt; The relative concentrations of sucrose and fructose at 5 samples in freeze drying method showed significant higher content than those in oven drying. On the other hands, glucose was mostly significant higher concentration in oven drying at 5 samples. Fructose and sucrose were significantly higher in freeze drying method than those in oven drying in &lt;em&gt;Curcuma and Zingiber&lt;/em&gt; genera. Relative glucose content was higher in oven drying at Curcuma genus &lt;strong&gt;Conclusion:&lt;/strong&gt; Therefore, oven drying method which applied heating at 500C is an appropriate method for herbal medicine production, especially in &lt;em&gt;Curcuma and Zingiber&lt;/em&gt; genus, for maintaining the major secondary metabolites.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">128</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dinar Sari C. Wahyuni&lt;sup&gt;1,*&lt;/sup&gt;, Siti A. E. Astuti&lt;sup&gt;1&lt;/sup&gt;, Soerya Dewi Marliyana&lt;sup&gt;2&lt;/sup&gt;, Yudi Rinanto&lt;sup&gt;3&lt;/sup&gt;, Tiara Dewi S. Pratama&lt;sup&gt;1&lt;/sup&gt;, Ahmad Fauzi&lt;sup&gt;4&lt;/sup&gt;, Ari Satia Nugraha&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacy Department, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;ChemistryDepartment, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Biology Education Program, Faculty of Teacher Training and Education, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani, Pabelan, Kartasura, Sukoharjo 57169, Central Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, University of Jember, Jl. Kalimantan I/2, Jember, 68121, East Java, INDONESIA.&amp;nbsp;&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bahrul Ilmi</style></author><author><style face="normal" font="default" size="100%">Parellangi</style></author><author><style face="normal" font="default" size="100%">Akhmad Rizani</style></author><author><style face="normal" font="default" size="100%">Hammad</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Elderly Hadrah Gymnastics on Muscle Strength  and Scope of Motion of Lower Extremity Joints in Elderly with  Osteoarthritis (Martapura River Region, South Kalimantan)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Elderly Hadrah Gymnastics</style></keyword><keyword><style  face="normal" font="default" size="100%">Joint Scope</style></keyword><keyword><style  face="normal" font="default" size="100%">Knee Muscles</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteoarthritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Pelvic Muscles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1126-1131</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Increased life expectancy (UHH) in Indonesia from 71.7 years in 2016 (Novianty, Nodia, 2018). And it is estimated to increase to 72.2 years in 2035 (BPS, 2016). The implication of increasing the number of elderly people with high UHH is expected to be healthy and productive elderly people and free from diseases and health problems, however, the results of a preliminary study in East Banjarmasin, the number of elderlies is 207 elderly (Posyandu, 2018). And almost 70% experience health problems such as osteoarthritis, so it is necessary to intervene in the form of Elderly Hadrah Gymnastics (SHL) which can increase muscle strength and scope of joint motion of the Elderly, so that the Elder can live healthy and free from osteoarthritis. The purpose of this study was to determine the effect of SHL on muscle strength and joint range of motion in elderly people with osteoarthritis in the Suburb area, Sungai Martapura Village, South Kalimantan Region. Quasi Experiment research design with The Non-Randomized Control Group Pretest Posttest Design approach, the population of all elderly in the Martapura River area with a total of 110 elderly (Pemko Dinkes, 2016). The research sample was the elderly living in the Martapura watershed who had osteoarthritis, non-random sampling, purposive sampling technique, with a total sample of 68 elderly consisting of the control and treatment groups, each of which was 34 participants. Both groups measured muscle strength and joint range of motion before and after treatment. Data analysis used Paired T-test for paired samples and Independent T-Test for unpaired samples with normal distribution. The results of research show There is an effect of SHL on the Strength of Pelvic and Knee Muscles of the Elderly as well as the effect of SHL on the Scope of Pelvic and Knee Joints in the Elderly. In the elderly who have osteoarthritis, they should do elderly Hadrah Gymnastics regularly at least 2 times a week.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1126</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Bahrul Ilmi&lt;sup&gt;1,&lt;/sup&gt;*, Parellangi&lt;sup&gt;1&lt;/sup&gt; , Akhmad Rizani&lt;sup&gt;1&lt;/sup&gt; , Hammad&lt;sup&gt;1&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;2&lt;/sup&gt; , Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Health Ministry of Health Polytechnic Banjarmasin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Public Health, Hasanuddin University Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fransiskus Geroda Mado</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Masyta Muis</style></author><author><style face="normal" font="default" size="100%">Ida Leida Maria</style></author><author><style face="normal" font="default" size="100%">Muhammad Syafar</style></author><author><style face="normal" font="default" size="100%">Darmawansyah</style></author><author><style face="normal" font="default" size="100%">Muhammad Alwi Arifin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Toto Sudargo</style></author><author><style face="normal" font="default" size="100%">Agustina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Family-Based Empowerment in Preventing Overweight and Obesity in Elementary School Children in Kupang</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Elementary School Children.</style></keyword><keyword><style  face="normal" font="default" size="100%">Empowerment</style></keyword><keyword><style  face="normal" font="default" size="100%">Family</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Overweigh</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">428-434</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The prevalence of overweight and obesity continues to increase in both developing and developed countries and occurs in all age groups. As well as being the biggest threat to public health, especially non-communicable diseases. Childhood is the most special period in life. It is almost certain that many health problems/illnesses experienced during this period will be carried on into adulthood. The causes of obesity in children are very complex; genetic, biological, psychosocial, behavioral and sociocultural factors. The impact of overweight and obesity on children is related to physical and psychological effects. Lifestyle modification which includes increasing knowledge, diet, physical activity, sedentary behavior, socio-cultural aspects is believed to be a strategy in preventing and controlling overweight and obesity. This study aims to examine the effect of family empowerment on the prevention of overweight and obesity in elementary school children. This research is a quasy experiment that is pre-test and posttest with control group design. Parallel design with one treatment group and one control group. The sample is determined by purposive random sampling. The research sample was overweight/obese children in elementary school grades 4, 5 and 6, totaling 112 people. Data were obtained through a structured questionnaire covering family abilities, knowledge, physical activity and nutritional intake. Nutritional status was measured after measuring body weight and height using digital scales. Eating patterns were measured using a food frequency questionnaire and a 24-hour recall formula.&lt;strong&gt; Results: &lt;/strong&gt;The results showed that there were differences in family ability (p&amp;lt;0.016), knowledge (p&amp;lt;0.001), physical activity (p&amp;lt;0.015) and nutritional intake (p&amp;lt;0.000) in the treatment group and the control group after implementing the family empowerment intervention. &lt;strong&gt;Conclusion: &lt;/strong&gt;Family-centered empowerment interventions through health education about overweight and obesity management have a positive impact on increasing family capacity, family knowledge, physical activity and changes in family eating patterns. It is necessary to implement lifestyle modifications in preventing and controlling overweight and obesity. Family-centered empowerment interventions through health education about overweight and obesity management have a positive impact on increasing family capacity, family knowledge, physical activity and changes in family eating patterns. It is necessary to implement lifestyle modifications in preventing and controlling overweight and obesity. Family-centered empowerment interventions through health education about overweight and obesity management have a positive impact on increasing family capacity, family knowledge, physical activity and changes in family eating patterns. It is necessary to implement lifestyle modifications in preventing and controlling overweight and obesity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">428</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fransiskus Geroda Mado&lt;sup&gt;1,2,*&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;3&lt;/sup&gt;, Masyta Muis&lt;sup&gt;3&lt;/sup&gt;, Ida Leida Maria&lt;sup&gt;3&lt;/sup&gt;, Muhammad Syafar&lt;sup&gt;3&lt;/sup&gt;, Darmawansyah, Muhammad Alwi Arifin&lt;sup&gt;3&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;3&lt;/sup&gt;, Toto Sudargo&lt;sup&gt;4&lt;/sup&gt;, Agustina&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Student Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Public Health, Nusa Cendana University, Kupang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Public health science, Faculty of Medicine, Gadjah Mada University, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Health Polytehnic Kupang, Ministry of Health, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Djatiwidodo Edi Pratiknya</style></author><author><style face="normal" font="default" size="100%">Risma</style></author><author><style face="normal" font="default" size="100%">Ariyo Sakso Bintoro</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Hyperbaric Oxygen Therapy (HBOT) on the  Histopathological Lung Cells of Male White Wistar Rats Which are  Intoxicated with Methanol</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histopathological Lung Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperbaric Oxygen Therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1202-1206</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Methanol is a liquid that has the characteristics of being light, very easy to evaporate, colorless, flammable, toxic, and has a very distinctive odor like ethanol but lighter. The World Health Organization (WHO) globally states that 320,000 people die every year due to methanol poisoning in the age range of around 15 years to 29 years. Usually, symptoms of poisoning caused by methanol appear within 30 minutes to 2 hours. Based on the phenomenon that occurred, the author wanted to find out more about the effect of HBOT administration on the histopathological appearance of lung cells in mice intoxicated with methanol. This study used 30 male white wistar rat lung samples aged 2 to 3 months weighing around 150 grams to 250 grams, divided into three groups, namely the control group, treatment group I, and treatment group II. The control group was not given methanol treatment and hyperbaric oxygen therapy (HBOT). Treatment group I was given methanol for 14 days without hyperbaric oxygen therapy. Meanwhile, the treatment group was given methanol for 14 days and then given hyperbaric therapy for 10 days. The results show p&amp;lt;0.0006, which means the data is significant and there are differences between groups. The results of this study can be concluded that administering hyperbaric oxygen therapy to rats intoxicated with methanol had a statistically significant improvement effect on the alveolar membrane, alveolar lumen, and connections between the alveoli.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1202</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Djatiwidodo Edi Pratiknya&lt;sup&gt;1,&lt;/sup&gt;*, Risma&lt;sup&gt;2&lt;/sup&gt; , Ariyo Sakso Bintoro&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Marine Health, Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Urology Surgery, Naval Central Hospital Dr. Ramelan Surabaya, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ihyan Amri</style></author><author><style face="normal" font="default" size="100%">Abdul Hafid Bajamal</style></author><author><style face="normal" font="default" size="100%">David S. Perdanakusuma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Hypnoanesthesia on Endogenous Opioids (Beta Endorphin and Enkephalin)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Beta-Endorphin</style></keyword><keyword><style  face="normal" font="default" size="100%">Enkephalin</style></keyword><keyword><style  face="normal" font="default" size="100%">Glutamic Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypnoanesthesia</style></keyword><keyword><style  face="normal" font="default" size="100%">Substance P.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">141-145</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Hypnoanesthesia is a state of anesthesia achieved through hypnosis techniques. Meanwhile, hypnosis is a condition in which the mind receives information without analyzing it. Hypnoanesthesia has been empirically utilized in surgery since the 18th century, but the mechanism remains unclear. &lt;strong&gt;Objective: &lt;/strong&gt;This study aims to prove nociceptive pain relief due to hypnoanesthesia in minor surgery, with indications of changes in the serum levels of several excitatory and inhibitory neurotransmitters in the physiological mechanism of pain. &lt;strong&gt;Methods:&lt;/strong&gt; The study subjects included patients with benign soft tissue tumors consisting of 40 people who were divided into 2 groups (treatment and control). The treatment group underwent minor surgery using hypnoanesthesia, while the control group underwent minor surgery using 2% lidocaine local anesthesia. Pain in both groups was measured by FPS (Face Pain Scale) and monitored by a vital sign monitor. Changes in the serum levels of glutamic acid, substance P, beta-endorphin and enkephalin neurotransmitters in both groups before and after the intervention were analyzed using ELISA. &lt;strong&gt;Results:&lt;/strong&gt; There were no significant changes in serum levels of neurotransmitters, pre and post intervention in both groups, both excitatory neurotransmitters Glutamic Acid and Substance P and inhibitory neurotransmitters Beta Endorphins and Enkephalin (p &amp;gt; 0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;Based on the results of the data analysis, it can be concluded that the empirical nociceptive pain relief occurred in patients who underwent minor surgery with hypnoanesthesia and there was no significant change in betaendorphin, enkephalin, glutamate acid, and substance P serum levels before and after hypnoanesthesia&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">141</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ihyan Amri&lt;sup&gt;1&lt;/sup&gt;, Abdul Hafid Bajamal&lt;sup&gt;2,*&lt;/sup&gt;, David S. Perdanakusuma&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Plastic Surgery, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ihyan Amri</style></author><author><style face="normal" font="default" size="100%">Abdul Hafid Bajamal</style></author><author><style face="normal" font="default" size="100%">David S. Perdanakusuma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Hypnoanesthesia on Serotonin</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Glutamate Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypnoanesthesia</style></keyword><keyword><style  face="normal" font="default" size="100%">Serotonin</style></keyword><keyword><style  face="normal" font="default" size="100%">Substance P.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">146-149</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Every minor and major surgical procedure requires anesthesia to relieve pain during surgery. The neuro-biomolecular mechanism of pain relief in hypnoanesthesia remains uncomprehended.&lt;strong&gt; Objective&lt;/strong&gt;: This study aims to observe the effect of hypnoanesthesia on several neurotransmitters, including serotonin, glutamic acid, and substance P, which play a role in the mechanism of pain. Methods: The study subjects included patients with benign soft tissue tumors consisting of 40 people who were divided into two groups, namely treatment and control groups. Minor surgery with hypnoanesthesia was performed in the treatment group, whereas in the control group, minor surgery was performed with 2% lidocaine local anesthetic. Pain in both groups was measured by FPS (Face Pain Scale) and monitored by a vital sign monitor. The processes of the study were recorded with a camcorder. Changes in serum levels of excitatory (glutamic acid and substance P) and inhibitory (serotonin) neurotransmitters before and after the intervention were analyzed using ELISA (Enzym-Link Immunosorbent Assay) in both groups. &lt;strong&gt;Results: &lt;/strong&gt;The control and treatment groups had the same end result, which was pain relief. The results of regression and ANOVA analysis indicated that serotonin simultaneously had a significant effect on substance P at 98.4% and glutamic acid at 98.2%. &lt;strong&gt;Conclusion: &lt;/strong&gt;There was no statistically significant change in serotonin levels before and after hypnoanesthesia. Serotonin, as an inhibitory neurotransmitter, simultaneously has a significant effect on both excitatory neurotransmitters, namely Glutamate Acid and Substance P, in the mechanism of nociceptive pain relief with hypnosis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">146</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ihyan Amri&lt;sup&gt;1&lt;/sup&gt;, Abdul Hafid Bajamal&lt;sup&gt;2,*&lt;/sup&gt;, David S. Perdanakusuma&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Plastic Surgery, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meti Megawati</style></author><author><style face="normal" font="default" size="100%">Toto Sudargo</style></author><author><style face="normal" font="default" size="100%">And Susetyowati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Jelly Candy Snake Fruit and Banana With Ferrous  Fumarat Fortified using Nano Technology in Adolescent Female  at Junior High School</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adolescent female</style></keyword><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Fortified</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Jelly Candy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1150-1155</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; Adolescent Female are a population at risk for anemia. Nutritional factors such as calories, protein, iron, dietary fiber, and folic acid induce this disease. Furthermore, fishy odor and nausea are two factors that contribute to adolescent females’ lack of iron consumption. Jelly candy formulations of snake and banana fruit with ferrous fumarate fortification using nanotechnology also decrease these diseases as an alternative to food consumption. Young adolescents ought to embrace this jelly formulation, considering its reasonable pricing. Therefore, this study aims to determine the effect of jelly candy formulations of snake and banana fruit with ferrous fumarate fortification using nanotechnology on the increase in hemoglobin levels. &lt;strong&gt;Materials And Methods:&lt;/strong&gt; A quasi-experimental approach was adopted with a Pretest-Posttest Control Group design. The study included a cohort of 150 adolescent girls hailing from Tamansari District, Tasikmalaya City, within the age range of 12 to 18 years. Additionally, the subjects were divided into three distinct groups, namely the treatments (involving jelly, snack fruit, banana, and ferrous fumarate supplementation, abbreviated as JEPISA), control group 1 (comprising jelly and ferrous fumarate supplementation, denoted as JFumarate), and control group 2 (receiving iron and folic acid supplementation as part of the Programme), each consisting of 50 participants. The sample selection process employed the purposive sampling technique and the collected data were subjected to analysis using T-Test, Chi-square and Multiple Logistic Regression methods. &lt;strong&gt;Results:&lt;/strong&gt; The results of the T-Test analysis showed that the mean rise in hemoglobin after lean period of 13 week after giving treatments increased hemoglobin levels by 0.65 ± 0.39 g/dl (95% CI 0.53-0.75 g/dl), significantly (p-value=0,000). Their mean post intervention haemoglobin of three group was 12.10 ± 0.80 g/dl, 12.42 ± 0.70 g/dl and 11.73 ± 0.90 g/dl respectively. The results of statistical test were obtained, the treatment and control group 1 (p=0,044) and the treatment and control group 2 (p=0,33). The result of the multivariate analysis showed that complaince (p=0,000), nutritional status (p=0,000) and menstrual duration (p=0,000) variable were confounding variables for the incidence of anemia (Exp(B)=17,769). &lt;strong&gt;Conclusion: &lt;/strong&gt;There were differences in Hb levels before and after administering the treatment. However, there was statistically significant difference between treatment with controls 1 and 2. Weekly supplementation of treatment’s in Iron Deficiency Anemia patients is as good as weekly supplementation of control 1 and but higher than control 2. Adolescent female who did not adhere to consuming iron had a chance of experiencing anemia 17,769 times compared to obedient adolescents after controlling for the variable nutritional status and length of menstruation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Meti Megawati&lt;sup&gt;1,&lt;/sup&gt;*, Toto Sudargo&lt;sup&gt;2&lt;/sup&gt; , And Susetyowati&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, 55281, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department Nutrition and Health, Faculty of Medicine, Public Health and Nursing of Program Faculty of Medicine, Public Health And Nursing of Universitas Gadjah Mada, Yogyakarta, 55281, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rasio Putra Hutama</style></author><author><style face="normal" font="default" size="100%">Alpha Fardah Athiyyah</style></author><author><style face="normal" font="default" size="100%">I.G.M. Reza Gunadi Ranuh</style></author><author><style face="normal" font="default" size="100%">Andy Darma</style></author><author><style face="normal" font="default" size="100%">Khadijah Rizky Sumitro</style></author><author><style face="normal" font="default" size="100%">Wibi Riawan</style></author><author><style face="normal" font="default" size="100%">Ingrid S. Surono</style></author><author><style face="normal" font="default" size="100%">Subijanto Marto Sudarmo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Lactobacillus Plantarum IS-10506 on Paneth Cell Regeneration in the Ileum of Sprague Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DEFA-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Escherichia coli O55:B5</style></keyword><keyword><style  face="normal" font="default" size="100%">Lactobacillus plantarum IS-10506</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipopolysaccharide</style></keyword><keyword><style  face="normal" font="default" size="100%">MATH-1.</style></keyword><keyword><style  face="normal" font="default" size="100%">Paneth cells</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">928-932</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pathogenic &lt;em&gt;Escherichia coli &lt;/em&gt;(E. coli) is the most common infectious agent among children in developing countries. Indigenous probiotics are not widely used to treat diarrhea and intestinal infections. This study aims to investigate the cell regeneration process of paneth cells after administration of &lt;em&gt;Lactobacillus plantarum&lt;/em&gt; IS-10506 due to damage caused by Lipopolysaccharide (LPS) &lt;em&gt;E. coli&lt;/em&gt; O55:B5, through the expression of MATH-1 and DEFA-6. &lt;strong&gt;Methods: &lt;/strong&gt;This study used 64 paraffin blocks from Rattus norvegicus strain Sprague-Dawley divided into four groups. There were three treatments, KN, KL, KP and KPR groups, The KN group represent the administration of placebo. The KL group received LPS &lt;em&gt;E. coli &lt;/em&gt;O55:B5 on day one. The KP group received LPS &lt;em&gt;E. coli&lt;/em&gt; O55:B5 on the first day and &lt;em&gt;Lactobacillus plantarum&lt;/em&gt; IS-10506 on the second day until six-day. The KPR group were administered &lt;em&gt;Lactobacillus plantarum&lt;/em&gt; IS- 10506 six days prior to receiving LPS &lt;em&gt;E. coli&lt;/em&gt; O55:B5, respectively. All groups, except KN, received LPS at a dose of 250 μg/kg body weight once, and Lactobacillus plantarum IS-10506 at a dose of 2.86x1010 CFU/ day. Evaluating paneth cell regeneration, DEFA-6, and MATH-1 expression immunohistochemistry was conducted on all tissues. &lt;strong&gt;Results:&lt;/strong&gt; The expression of DEFA-6 and MATH-1 in the KP and KPR groups on day three of observation was significantly higher from the KL group. Even though the KL group achieved significant growth, the results of this expansion were significantly smaller than KP and KPR groups. &lt;strong&gt;Conclusion:&lt;/strong&gt; After mucosal injury caused by LPS &lt;em&gt;E. coli &lt;/em&gt;O55:B5, administration of probiotic &lt;em&gt;Lactobacillus plantarum&lt;/em&gt; IS-10506 may increase paneth cell regeneration through differentiation and cell number.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">928</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rasio Putra Hutama&lt;sup&gt;1&lt;/sup&gt;, Alpha Fardah Athiyyah&lt;sup&gt;1,*&lt;/sup&gt;, I.G.M. Reza Gunadi Ranuh&lt;sup&gt;1&lt;/sup&gt;, Andy Darma&lt;sup&gt;1&lt;/sup&gt;, Khadijah Rizky Sumitro&lt;sup&gt;1&lt;/sup&gt;, Wibi Riawan&lt;sup&gt;2&lt;/sup&gt;, Ingrid S. Surono&lt;sup&gt;3&lt;/sup&gt;, Subijanto Marto Sudarmo&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Child Health, Faculty of Medicine Universitas Airlangga. Dr. Soetomo General Academic Teaching Hospital, Mayjend. Prof. Dr. Moestopo No. 6-8, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Biochemistry and Biomolecular Universitas Brawijaya, Veteran Street, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Food Technology Department, Faculty of Engineering, Bina Nusantara University, Jakarta 11480, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rahma</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">A. Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Aminuddin Syam</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Abd. Farid Lewa</style></author><author><style face="normal" font="default" size="100%">Haerani Harun</style></author><author><style face="normal" font="default" size="100%">Miranti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Moringa Leaf Extract Intervention Since Preconception Period on the Prevention of Oxidative Stress in Pregnant Women and Adverse Pregnancy Outcomes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Malondialdehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy outcomes.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">310-314</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Oxidative stress occurs due to an imbalance of oxidants and anti-oxidants and is often associated with poor pregnancy outcomes. Therefore, additional supplementation is needed since the preconception period to prevent oxidative stress and poor pregnancy outcomes. This study aims to examine the effect of supplementing Moringa leaf extract on the prevention of oxidative stress in pregnant women and poor pregnancy outcomes. &lt;strong&gt;Methods: &lt;/strong&gt;This study is an observational study with a prospective cohort study design. The research subjects were third trimester pregnant women consisting of 2 groups, namely the control group who only received Iron-Folic Acid (IFA) supplements (n = 30) and the group that received moringa leaf extract and IFA supplements (n = 26). Then an examination of Malondialdehyde (MDA) levels as a biomarker of oxidative stress was carried out using the ELISA (enzyme-link immune sorbent) method, followed by pregnancy outcomes including birth weight and birth length. Data were analyzed by unpaired t test. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that there were no significant differences in the levels of MDA, birth weight and birth length in the two groups with a p value &amp;gt; 0.05. Nevertheless, MDA level in IFA group was 49.25 nmol/ml higher than Moringa + IFA group which was 47.58 nmol/ml. Likewise, the average of birth weight and birth length in Moringa group were 3042.3 grams and 48.62 cm higher than IFA group which were 2993.7 grams and 48.23 cm. Malondialdehyde levels were also higher in women who had babies with birth weight &amp;lt; 2500 grams was 49.48 nmol/ml and birth length &amp;lt; 48 cm was 49.13 nmol/l compared to birth weight ≥ 2500 grams was 48.50 nmol/ml and birth length ≥ 48 cm was 48.62 nmol/ml but there was no significant difference in the two groups (p&amp;gt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Oxidative stress in pregnant women tends to be associated with poor pregnancy outcomes. Moringa leaf extract supplementation since preconception can prevent increased oxidative stress and improve pregnancy outcomes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">310</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rahma&lt;sup&gt;1,*&lt;/sup&gt;, Veni Hadju&lt;sup&gt;2&lt;/sup&gt;, A. Arsunan Arsin&lt;sup&gt;3&lt;/sup&gt;, Aminuddin Syam&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;, Abd. Farid Lewa&lt;sup&gt;5&lt;/sup&gt;, Haerani Harun&lt;sup&gt;1&lt;/sup&gt;, Miranti&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Student of Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Nutritional Sciences, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Enviromental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Departement of Nutrition health, Polytechnic of Palu, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gilmar Peña-Rojas</style></author><author><style face="normal" font="default" size="100%">Luz Quispe-Calle</style></author><author><style face="normal" font="default" size="100%">Vidalina Andía-Ayme</style></author><author><style face="normal" font="default" size="100%">Alex Pereda-Medina</style></author><author><style face="normal" font="default" size="100%">Rolando Estrada- Jimenez</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Elizabeth Julia Melgar-Merino</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Naphthaleneacetic Acid (NAA) and 6-Benzylamino Purine (BAP) on In-Vitro Propagation of &quot;Mashua&quot; (Tropaeolum tuberosum Ruíz &amp; Pavón) Morphotypes from Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BAP.</style></keyword><keyword><style  face="normal" font="default" size="100%">Mashua</style></keyword><keyword><style  face="normal" font="default" size="100%">Micropropagation</style></keyword><keyword><style  face="normal" font="default" size="100%">NAA</style></keyword><keyword><style  face="normal" font="default" size="100%">Tropaeolum tuberosum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">563-568</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruız &amp;amp; Pavón “mashua” is a native species of the central Andes and different propagation methods&lt;em&gt; in vitro &lt;/em&gt;have been evaluated. However, this research has studied the &lt;em&gt;in vitro &lt;/em&gt;propagation of 15 mashua (&lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruíz &amp;amp; Pavón) morphotypes from the Ayacucho and Apurímac regions (Peru) &lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the effect of the additives naphthaleneacetic acid (NAA) and 6-benzylamino purine (BAP) on the micro-propagation rate of &lt;em&gt;T. tuberosum&lt;/em&gt;. &lt;strong&gt;Material and Methods: &lt;/strong&gt;For &lt;em&gt;in vitro&lt;/em&gt; establishment, seedlings were used after disinfection with sodium hypochlorite, propagated in Murashige and Skoog (MS) medium. For the evaluation of the effect of NAA and BAP additives, nodes were isolated from &lt;em&gt;in vitro&lt;/em&gt; seedlings after 30 days of cultivation and transferred to MS medium supplemented with 3% sucrose, pH 5.6 and 7 g/L of agar according to T1 (MS + NAA 1ppm) and T2 (MS + BAP 1ppm) treatments. The samples were cultivated for 28 days at 19 °C ± 2 °C with photoperiods of 16 h/light and 8 h/darkness.&lt;strong&gt; Results: &lt;/strong&gt;After evaluating 20 repetitions for each of the three treatments, the addition of NAA or BAP does not improve the micropropagation rate of practically all the morphotypes studied. Furthermore, BAP behaved as an inhibitor of the development of mashua seedlings. &lt;strong&gt;Conclusion: &lt;/strong&gt;The best micropropagation medium of &lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruíz &amp;amp; Pavón (mashua) is the basic Murashige and Skoog (MS) medium without the NAA or BAP additives.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">563</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gilmar Peña-Rojas&lt;sup&gt;1,*&lt;/sup&gt;, Luz Quispe-Calle&lt;sup&gt;1&lt;/sup&gt;, Vidalina Andía-Ayme&lt;sup&gt;2&lt;/sup&gt;, Alex Pereda-Medina&lt;sup&gt;3&lt;/sup&gt;, Rolando Estrada- Jimenez&lt;sup&gt;4&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;5&lt;/sup&gt;, Elizabeth Julia Melgar-Merino&lt;sup&gt;6&lt;/sup&gt;, José Santiago Almeida-Galindo&lt;sup&gt;6&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;7,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Cellular and Molecular Biology, Biological Sciences Faculty, Universidad Nacional de San Cristóbal de Huamanga, Portal Independencia 57, Ayacucho 05003, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Food Microbiology, Biological Sciences Faculty, Universidad Nacional de San Cristóbal de Huamanga, Portal Independencia 57, Ayacucho 05003, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratorio de Teledetección y Física. Universidad Nacional de San Cristóbal de Huamanga, Ayacucho 05003 PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratorio de Recursos Genéticos y Biotecnología, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Chemistry Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Pharmacy and Biochemistry Faculty, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chayut Fongsuk</style></author><author><style face="normal" font="default" size="100%">Patnaree Wongmanit</style></author><author><style face="normal" font="default" size="100%">Kanoktip Pansuksan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Plant Stage and Solvent Extraction on Catechin Contents in  Borrasus flabellifer L. Male Flower</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Borrasus flabellifer L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Catechin</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Male flower</style></keyword><keyword><style  face="normal" font="default" size="100%">Mature</style></keyword><keyword><style  face="normal" font="default" size="100%">Young</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1036-1041</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Borrasus flabellifer L&lt;/em&gt;. is a plant in the Arecaceae (Palmae) family with numerous bioactivities such as diuretic promotion, antioxidant, and antimicrobial effects. In this study, we are interested in the phytochemical compounds present in &lt;em&gt;B. flabellifer &lt;/em&gt;L. male flowers. We investigated the effects of plant stage and solvent used for extraction. Initially, both the young and mature male flowers of this plant were extracted using water or ethanol. Several standard compounds, including gallic acid, catechin, caffeic acid, and quercetin, were utilized to screen the phytochemicals in these plant flowers. After analyzing the samples using High-Performance Liquid Chromatography (HPLC) method, only catechin was detected in all extracts, while the others were not detected (did not match the peak spectrum pattern compared with standard). Using a detection wavelength and curve parameters with an R2 value of 0.9999, catechin detection via HPLC was performed at 280 nm within the range of 13.12 to 210.00 µg/mL detection. Regarding the stage of the male flower, the young ones extracted with water provided the highest catechin content at 6.65 µg/mg extract, while the others fell within the range of 4.02 to 4.44 µg/mg extract. Therefore, it has been confirmed that catechin can be found in B. &lt;em&gt;flabellifer &lt;/em&gt;L., and water should be used as the solvent for extraction for further applications of this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1036</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Chayut Fongsuk&lt;sup&gt;1 &lt;/sup&gt;, Patnaree Wongmanit&lt;sup&gt;2&lt;/sup&gt; , Kanoktip Pansuksan&lt;sup&gt;3,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Srinakharinwirot University, Nakhon Nayok, 26120, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Graduate Student in Division of Integrative Medicine, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Teguh Triyono</style></author><author><style face="normal" font="default" size="100%">Zelly Dia Rofinda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Platelet Concentrates (PCs) Leucodepletion on the Activation and Efficacy of Platelet Transfusion</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CD62P</style></keyword><keyword><style  face="normal" font="default" size="100%">Corrected count increment</style></keyword><keyword><style  face="normal" font="default" size="100%">Platelet concentrates</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">223-227</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Platelet concentrates (PCs) are blood components transfused in thrombocytopenic patients, including patients with blood malignancies. PCs contain leukocytes, which can pose potential side effects and activate platelets, reducing the efficacy of platelet transfusion. The leucodepletion process can be carried out by filtration to reduce the leukocyte count. This study aims to determine the difference between the CD62P expression of nonleucodepleted and leucodepleted PCs and to determine the difference between the Corrected Count Increment (CCI) of patients transfused with nonleucodepleted and leucodepleted PCs. This analytic observational study with a cross-sectional design was carried out on PCs obtained from platelet-rich plasma (PRP-PC). PCs were transfused into 48 blood malignancy patients, Yogyakarta, consisting of two groups i.e the group transfused with nonleucodepleted PCs (24 patients) and the group transfused with leucodepleted PCs (24 patients). CD62P expression in PCs was measured by flow cytometry method, and the CCI of the patients was calculated based on the CCI formula. The difference between the median CD62P expression and CCI of the two groups was analyzed using the Mann- Whitney Test with a significance of p&amp;lt;0.05. The median CD62P expression of the nonleucodepleted and leucodepleted groups were 34.4% (16.8–94.4%) and 21.7% (6.2–34.0%), respectively. There was a statistically significant difference between the CD62P expression of the two groups (p = 0.00). The group transfused with nonleucodepleted, and leucodepleted PCs showed respective median CCI of 18.8 x 10&lt;sup&gt;9&lt;/sup&gt;/L (2.4–94.8 x 10&lt;sup&gt;9&lt;/sup&gt;/L) and 14.7 x 10&lt;sup&gt;9&lt;/sup&gt;/L (2.4–124.0 x 10&lt;sup&gt;9&lt;/sup&gt;/L). There was no statistically significant difference between the CCI of the two groups (p = 0.42). It can be concluded that the CD62P expression in the PCs of the leucodepleted group was significantly lower than those of the nonleucodepleted group and that there was no significant difference between the CCI of both groups.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">223</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Teguh Triyono&lt;sup&gt;1*&lt;/sup&gt;, Zelly Dia Rofinda&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haerani Harun</style></author><author><style face="normal" font="default" size="100%">Anwar Daud</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">M Sabir</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Rahma</style></author><author><style face="normal" font="default" size="100%">Miranti</style></author><author><style face="normal" font="default" size="100%">Tamrin Talebe</style></author><author><style face="normal" font="default" size="100%">M. Faris</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Preconcenption Moringa Leaf Extract Supplementation on Cotinine Serum Levels in Pregnant Women Exposed to Tobacco Smoke</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cotinine</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera.</style></keyword><keyword><style  face="normal" font="default" size="100%">Preconception</style></keyword><keyword><style  face="normal" font="default" size="100%">Tobacco smoke</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">290-293</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Moringa oleifera &lt;/em&gt;is known for its nutrition content, antioxidant and medical benefit. Tobacco smoke contains various toxic substance and can affect the pregnancy. To reduce the tobacco smoke effect on pregnancy outcome good nutrition is needed. &lt;strong&gt;Objective: &lt;/strong&gt;This study aims to assess the effect of Moringa leaf extract on serum cotinine levels in pregnant women exposed to second-hand tobacco smoke.&lt;strong&gt; Method:&lt;/strong&gt; This is an observational study with a prospective cohort study design the study population was pregnant women which were divided by 2 groups, first group received IFA supplements only (n = 30) and the second group receive IFA and Moringa leaf extract supplements (n = 26). The tobacco smoke exposure data collected with questionnaire, and cotinine serum by blood sample. The tobacco smoke exposure and cotinine serum levels were compered between the two groups.&lt;strong&gt; Results: &lt;/strong&gt;The tobacco smoke exposures at home were higher in MO+IFA group pregnant women then the IFA group pregnant women (p&amp;lt;0,05). The cotinine serum levels in both groups were found not significantly different (p=0,535). These results indicate that pregnant woman with high exposure of tobacco smoke who MO receive have similar cotinine serum levels with the pregnant woman with lower exposure of tobacco smoke. &lt;strong&gt;Conclusion:&lt;/strong&gt; Moringa leaf extract supplementation to pregnant women with high tobacco smoke exposure has serum cotinine levels similar to pregnant women with lower exposure to tobacco smoke.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">290</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Haerani Harun&lt;sup&gt;1,*&lt;/sup&gt;, Anwar Daud&lt;sup&gt;2&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;3&lt;/sup&gt;, M Sabir&lt;sup&gt;4&lt;/sup&gt;, Veni Hadju&lt;sup&gt;5&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;2&lt;/sup&gt;, Rahma&lt;sup&gt;1&lt;/sup&gt;, Miranti&lt;sup&gt;4&lt;/sup&gt;, Tamrin Talebe&lt;sup&gt;6&lt;/sup&gt;, M. Faris&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Student of Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Professor, Department of Enviromental Health, Public Health Faculty Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Professor, Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Associate Professor, Department of Microbiology,Medical faculty Tadulako University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Nutritional Sciences, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Associate professor, Ushuluddin Faculty, Datokarama State Islamic University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Irham Taufiqurrahman</style></author><author><style face="normal" font="default" size="100%">Siti Hajar Norma Gupita</style></author><author><style face="normal" font="default" size="100%">Beta Widya Oktiani</style></author><author><style face="normal" font="default" size="100%">Isyana Erlita</style></author><author><style face="normal" font="default" size="100%">Andi Zulkifli</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Eko Suhartono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Ramania Leaves Extract Gel (Bouea macrophylla  Griff) on the Number of Osteoblast (in vivo Study of Post  Extraction in Wistar Rats (Rattus norvegicus))</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bouea macrophylla Griff</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteoblast</style></keyword><keyword><style  face="normal" font="default" size="100%">Ramania leaf extract gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Secondary  metabolite</style></keyword><keyword><style  face="normal" font="default" size="100%">Tooth extraction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1219-1223</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Ramania leaves extract contains secondary metabolite compounds such as flavonoids, steroids, phenols and terpenoids which can be used as an alternative medicine for socket wound healing. Flavonoids have anti-inflammatory and antioxidant properties that can accelerate wound healing and can stimulate the formation of osteoblasts. Analyzing the differences in the number of osteoblasts in the negative control group, positive control given aloe vera gel 15% and ramania leaf extract gel 15% on day 5, 7 and 14. This study used true experimental design with posttest-only control design, using 27 rats divide into 3 groups. The experimental animals were sacrificed on days 5, 7 and 14 for histopathological observations. Two-Way ANOVA test results obtained p value = 0.013 &amp;lt;0.05, which indicates that there is a significant difference between the use of 15% ramania leaf extract gel 15% and the number of osteoblasts on days 5, 7 and 14. Bonferroni's Post Hoc test showed a difference. The number of osteoblasts was significant among the negative control group with ramania leaf extract gel 15%. Ramania leaf extract gel 15% was proven to be able to increase the number of osteoblasts and has the potential as an alternative medicine for socket healing after tooth extraction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1219</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Irham Taufiqurrahman&lt;sup&gt;1,2,&lt;/sup&gt;*, Siti Hajar Norma Gupita&lt;sup&gt;3&lt;/sup&gt; , Beta Widya Oktiani&lt;sup&gt;4&lt;/sup&gt; , Isyana Erlita&lt;sup&gt;5&lt;/sup&gt; , Andi Zulkifli&lt;sup&gt;6&lt;/sup&gt; , Veni Hadju&lt;sup&gt;6&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;6&lt;/sup&gt; , Eko Suhartono&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Periodontist, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Departement of Conservative Dentistry, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Faculty of Public Health, Hasanuddin University, Makassar – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Departement of Medical Chemistry/ Biochemistry, Faculty of Medicine, Lambung Mangkurat University, Banjarbaru, South Kalimantan – INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Luis Enrique Rosales-Cerquin</style></author><author><style face="normal" font="default" size="100%">Santiago M. Benites</style></author><author><style face="normal" font="default" size="100%">Taniht Lisseth Cubas-Romero</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">José Gilberto Gavidia-Valencia</style></author><author><style face="normal" font="default" size="100%">Iris Melina Alfaro-Beltrán</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Rosmarinus Officinalis Essential Oil On Anxiety, Depression, And Sleep Quality</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Rosmarinus officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sleep quality</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">343-349</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The objective of this investigation was to evaluate the effect of &lt;em&gt;Rosmarinus officinalis &lt;/em&gt;essential oil on anxiety, depression, and sleep quality. &lt;strong&gt;Methods: &lt;/strong&gt;The essential oils were extracted by hydro-distillation using a modified Clevenger-type apparatus and the chemical composition was performed by Gas chromatography with flame ionization detection (GC-FID) and Gas chromatography mass spectrometry (GC–MS). Furthermore, a quasi-experimental study was conducted, where 81 participants were divided into two groups, comprising a waiting list control group and an experimental group treated with essential oils. Anxiety and depression indexes were evaluated using the Zung Self-Rating Anxiety Scale (SAS) and the Zung Self-Rating Depression Scale (SDS), and sleep quality was measured with the Pittsburgh Sleep Quality Inventory (PSQI). &lt;strong&gt;Results:&lt;/strong&gt; Chemical analysis showed that 1,8 cineole (37.6%), α-pinene (19.9%), and linalool (15.8%) were the main components. Anxiety, depression, and sleep quality scores showed a decrease in the post-test study phase compared to the pre-test in the experimental group (p&amp;lt;0.05). A large size effect was found in the case of anxiety (d = 1.491; g= 1.490) with 1-β=0.996, while medium size effects were observed for depression (d = 0.581; g= 0.582) with 1-β=0.585; and sleep quality (d = 0.586; g = 0.588) with 1-β=0.638. &lt;strong&gt;Conclusion: &lt;/strong&gt;Essential oils extracted from &lt;em&gt;Rosmarinus officinalis&lt;/em&gt; are more effective in calming anxiety and show moderate changes in depression and sleep quality.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">343</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado-García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto-Vásquez&lt;sup&gt;2&lt;/sup&gt;, Luis Enrique Rosales-Cerquin&lt;sup&gt;3&lt;/sup&gt;, Santiago M. Benites&lt;sup&gt;4&lt;/sup&gt;, Taniht Lisseth Cubas- Romero&lt;sup&gt;1&lt;/sup&gt;, Demetrio Rafael Jara- Aguilar&lt;sup&gt;2&lt;/sup&gt;, José Gilberto Gavidia-Valencia&lt;sup&gt;2&lt;/sup&gt;, Iris Melina Alfaro-Beltrán&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Psicología. Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Hospital de Apoyo Chepén, Chepén, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Instituto Pablo Casals, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Darius Tandiabang</style></author><author><style face="normal" font="default" size="100%">Syamsiar S. Russeng</style></author><author><style face="normal" font="default" size="100%">Lalu Muhammad Saleh</style></author><author><style face="normal" font="default" size="100%">Atjo Wahyu</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Safety Climate on Safety Behavior with Safety Motivation as An Intervening Variable on Contractor Workers in PT X</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Contractor workers</style></keyword><keyword><style  face="normal" font="default" size="100%">Path analysis.</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety behaviour</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety climate</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety motivation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">411-416</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Safety climate in the workplace and safety behaviour of workers need attention to be able to assess what factors are the causes of safe action for workers. This study aims to determine the effect of safety climate on safety behaviour with safety motivation as an intervening variable on contractor workers at PT X. The type of research is analytical observational with a cross sectional design. Questionnaires were given to 380 respondents. The data were analyzed using path analysis to see the direct and indirect effects of safety climate on safety behaviour. The results showed, 361 respondents (95%) with good safety climate, 367 respondents (96.9%) with good safety motivation, and 348 respondents (91%) with good safety behaviour. The path analysis showed that there was no direct influence of safety climate on safety behaviour in contractor workers at PT X (p value &amp;gt;0.05). However, the safety climate indirectly affects safety behaviour through safety motivation (p value = 0.001). It is recommended to workers that they need to maintain and increase their motivation so the safe work behaviour will still create.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">411</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Darius Tandiabang&lt;sup&gt;1&lt;/sup&gt;, Syamsiar S. Russeng&lt;sup&gt;1&lt;/sup&gt;, Lalu Muhammad Saleh&lt;sup&gt;1&lt;/sup&gt;, Atjo Wahyu&lt;sup&gt;1&lt;/sup&gt;, Yahya Thamrin&lt;sup&gt;1&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Occupational health and Safety, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Environmental health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tridiganita Intan Solikhah</style></author><author><style face="normal" font="default" size="100%">Tania Anggreani Wijaya</style></author><author><style face="normal" font="default" size="100%">Salsabila</style></author><author><style face="normal" font="default" size="100%">Daffa Alice Pavita</style></author><author><style face="normal" font="default" size="100%">Ragil Kusnandar Miftakhurrozaq</style></author><author><style face="normal" font="default" size="100%">Hartanto Mulyo Raharjo</style></author><author><style face="normal" font="default" size="100%">Maya Nurwartanti Yunita</style></author><author><style face="normal" font="default" size="100%">Faisal Fikri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Sapodilla Leaf Extract (Manilkara zapota L.) on Lipid Profiles of Alloxan-Induced Diabetic Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alloxan</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid Protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Manilkara zapota</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">286-289</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The aim of this study is to examine the effect of sapodilla leaf extract on lipid profiles of alloxan-induced diabetic mice. This research method are 30 male mice were used as experimental animals, which were randomly divided into five groups, each group consisting of 6 mice. The division of the group is as follows: Treatment of non-diabetic mice, diabetic mice, diabetic mice by administering pioglitazone at a dose of 2 mg/kg BW, extracts of manila sapodilla leaf (&lt;em&gt;M. zapota&lt;/em&gt; L.) dose 100 mg/kg BW and 300 mg/kg BW. Observations were made on the 14th day, after administration of sapodilla leaf extract, mice were given light anesthesia and serum lipid profiles Total Cholesterol (TC), triglycerides (TG), High-Density Lipoprotein (HDL), and Low-Density Lipoprotein (LDL) were measured using diagnostic kits (Pars Azmoon Kit) and automatic analyzer (Abbot, model Alcyon 300). The results of this study are in TC, there was a significant difference in pioglitazone and 100 mg leaf extract against all treatment groups. In TG, there was a significant difference in pioglitazone and 300 mg leaf extract against all treatment groups. In LDL, there were significant differences in the 100 mg, 300 mg leaf extract and pioglitazone, against negative control, and diabetes control. In HDL, there was a significant difference in negative control and 300 mg leaf extract, against 100 mg leaf extract, pioglitazone, and diabetes control. The conclusions of this study exhibited the ethanol extract of&lt;em&gt; M. zapota&lt;/em&gt; leaves contains several phytochemical compounds including alkaloids, flavonoids, saponins, polyphenols, tannins, quinones, and steroids. &lt;em&gt;M. zapota &lt;/em&gt;leaves extract (100 mg/kg and 300 mg/kg) exhibited a significant effect on improvement in lipid protein.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">286</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tridiganita Intan Solikhah&lt;sup&gt;1,2,*&lt;/sup&gt;, Tania Anggreani Wijaya&lt;sup&gt;1,2&lt;/sup&gt;, Salsabila&lt;sup&gt;1,2&lt;/sup&gt;, Daffa Alice Pavita&lt;sup&gt;1,2&lt;/sup&gt;, Ragil Kusnandar Miftakhurrozaq&lt;sup&gt;3&lt;/sup&gt;, Hartanto Mulyo Raharjo&lt;sup&gt;4&lt;/sup&gt;, Maya Nurwartanti Yunita&lt;sup&gt;5&lt;/sup&gt;, Faisal Fikri&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Veterinary Clinic, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Health and Life Science, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Universitas Jember, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Microbiology, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Veterinary Pathology, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Division of Veterinary Clinical Pathology and Physiology, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rara Armita Arman</style></author><author><style face="normal" font="default" size="100%">Syahrir A Pasinringi</style></author><author><style face="normal" font="default" size="100%">Fridawaty Rivai</style></author><author><style face="normal" font="default" size="100%">Andi Indahwaty Sidin</style></author><author><style face="normal" font="default" size="100%">Irwandy</style></author><author><style face="normal" font="default" size="100%">Lalu Muhammad Saleh</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Service Quality and Patient Satisfaction Toward Patient Loyalty in Special Regional Hospitals of South Sulawesi</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Patient Loyalty</style></keyword><keyword><style  face="normal" font="default" size="100%">Patient Satisfaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Regional Special Hospital.</style></keyword><keyword><style  face="normal" font="default" size="100%">Service Quality</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">443-449</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The improvement and guarantee of hospital Service Quality in Indonesia should always be in the best interest of any hospital as regulated in Article 40 of Hospital Law No. 44 of 2009. Adequate Service Quality in a hospital would result in emotional bonds and positive experiences felt by patients and family, eventually strengthening loyalty in the long run. Thus, Service Quality is a critical aspect and indicator to achieve patient satisfaction hence behavioral intention to build loyalty towards the hospital and future visits. The aim of this study is to identify the effect of Service Quality and patient satisfaction in relation to patient loyalty in Special Regional Hospitals of South Sulawesi. This is a quantitative study with a crosssectional model. The sample in this study were all patients who had been registered in the database, namely patients who had visited the outpatient service at Dadi Special Regional Hospital (RSKD), Siti Fatimah Regional Special Hospital for Mother and Child (RSKDIA), and Pertiwi Special Regional Hospital for Mother and Child (RSKDIA) in 2017-2019 with a total sample of 269 from the outpatient care, respectively. The inclusion criteria in this study are as follows: (1) Patients from the outpatient care. (2) Patients who had received hospital services twice. (3) Not suffering from any mental illness and sensory disturbances. (4) Patients who are willing to be respondents and consented to fill out research questionnaires. (5) The patient is conscious and is able to communicate. The results that were obtained show that Service Quality holds a significant effect on patient satisfaction. Service Quality has no significant effect on patient loyalty, while patient satisfaction has a significant effect on patient loyalty. The output of this study should be taken into consideration for hospitals to commit to improving the Service Quality in order to achieve patient satisfaction. Increased patient satisfaction in turn will develop loyalty, thereby accommodating the implementation of the hospital strategy and achieving hospital goals.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">443</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rara Armita Arman&lt;sup&gt;1&lt;/sup&gt;, Syahrir A Pasinringi&lt;sup&gt;1&lt;/sup&gt;, Fridawaty Rivai&lt;sup&gt;1&lt;/sup&gt;, Andi Indahwaty Sidin&lt;sup&gt;1&lt;/sup&gt;, Irwandy&lt;sup&gt;1&lt;/sup&gt;, Lalu Muhammad Saleh&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Hospital Management, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raden Anita Indriyanti</style></author><author><style face="normal" font="default" size="100%">Eko Fuji Ariyanto</style></author><author><style face="normal" font="default" size="100%">Hermin Aminah Usman</style></author><author><style face="normal" font="default" size="100%">Ristaniah Rose Effendy</style></author><author><style face="normal" font="default" size="100%">Diah Dhianawaty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The effect of Sinensetin and Imperatorin on A-549 lung cancer cell viability in vitro</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A549</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell viability</style></keyword><keyword><style  face="normal" font="default" size="100%">Imperatorin</style></keyword><keyword><style  face="normal" font="default" size="100%">Sinensetin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">38-46</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Lung cancer remains the leading cause of cancer death worldwide, so research is ongoing to discover new therapeutics, such as plant-derived bioactive compounds. For example, Sinensetin, a plant-derived polymethoxylated flavonoid, and Imperatorin, a natural furanocoumarin, have anti-cancer properties. This study assessed the effects of sinensetin and imperatorin separately and in combination on A-549 lung cancer cell viability. &lt;strong&gt;Method: &lt;/strong&gt;The A-549 lung cancer cell line was treated with sinensetin (60 μM), imperatorin (30 M), or a combination of both compounds (Sin:Imp 30:30 μM; 50:50 μM and 60:30 μM) for 48 hours. Cell viability was then assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay and apoptosis was determined using fluorescein isothiocyanate (FITC) Annexin-V/Propidium iodide staining. &lt;strong&gt;Results: &lt;/strong&gt;The combination treatment of Sin:Imp 50:50 and Sin:Imp 60:30 μM reduced cell viability more than the individual treatment of sinensetin and imperatorin, with the lowest cell viability observed for the combination treatment of Sin:Imp 50:50 μM. Likewise, the combination treatment of Sin:Imp 50:50 μM induced the most apoptosis compared to individual treatment. &lt;strong&gt;Conclusion:&lt;/strong&gt; Sinensetin and imperatorin can decrease A-549 lung cancer cell viability and are potent apoptotic inducers, especially when they are used in combination, therefore they are potential lung cancer therapeutics.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">38</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Raden Anita Indriyanti&lt;sup&gt;1,2,*&lt;/sup&gt;, Eko Fuji Ariyanto&lt;sup&gt;3&lt;/sup&gt;, Hermin Aminah Usman&lt;sup&gt;4&lt;/sup&gt;, Ristaniah Rose Effendy&lt;sup&gt;5&lt;/sup&gt;, Diah Dhianawaty&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Bandung Islamic University, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Doctoral Program in Medical Science, Faculty of Medicine, Padjadjaran University, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biomedical Sciences, Division of Biochemistry and Molecular Biology, Faculty of Medicine, Padjadjaran University, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department Pathology Anatomy, Faculty of Medicine, Padjadjaran University, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Radiology, Faculty of Medicine, Padjadjaran University, Bandung, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maya Nurwartanti Yunita</style></author><author><style face="normal" font="default" size="100%">Julia Calvina Fauzi</style></author><author><style face="normal" font="default" size="100%">Zahra Defitra Rahmania</style></author><author><style face="normal" font="default" size="100%">Bella Safinda</style></author><author><style face="normal" font="default" size="100%">Tridiganita Intan Sholikhah</style></author><author><style face="normal" font="default" size="100%">Bodhi Agustono</style></author><author><style face="normal" font="default" size="100%">M. Gandul Atik Yuliani</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Reina Puspita Rahmaniar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Single-Bulb Garlic (Allium sativum Var. Solo Garlic) Extract on The Hematological Profile In E-Cigarette-Induced Male Sprague Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">E-cigarette</style></keyword><keyword><style  face="normal" font="default" size="100%">Good health</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematology profile</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">296-300</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Garlic and its derivative preparations have long been used in traditional medicine for good health. Garlic is known to act as an antioxidant, antitumor, antibacterial, and antifungal. The antioxidant compound in singlebulb garlic is considered to be better than the antioxidant content in other species of garlic. This research aimed to study the effect of hematological profile in oral administration of single-bulb garlic extract in e-cigarette-induced male &lt;em&gt;Sprague Dawley&lt;/em&gt; rats. The method used in this study was randomized post-test only control group design. Twenty-four rats were randomly distributed into six groups. The group consisted of C (-) as normal rats’ control; C (+) only exposed to e-cigarette smoke; T1 exposed to e-cigarette smoke and treated with vitamin C; T2 exposed to e-cigarette and treated with single-bulb garlic extract 75 mg/kg BW; T3 exposed to e-cigarette and treated with single-bulb garlic extract 100 mg/kg BW; and T4 exposed to e-cigarette and treated with single-bulb garlic extract 125 mg/kg BW. Exposure to e-cigarette smoke is conducted by evaporating the liquid into a gas chamber with a nicotine dose of 3.6 mg/ml. All treatments were given for 14 days. On the 15th day, the rats were sacrificed. Blood samples were collected by the cardiac puncture method and were examined using a hematology analyzer. Data obtained were white blood count (WBC), platelets, hemoglobin, hematocrit, and erythrocytes that were analyzed with one-way ANOVA. The result of this study is that garlic extract may boost immunity in the body. However, higher doses can be toxic to erythrocytes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">296</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maya Nurwartanti Yunita&lt;sup&gt;1*&lt;/sup&gt;, Julia Calvina Fauzi&lt;sup&gt;2&lt;/sup&gt;, Zahra Defitra Rahmania&lt;sup&gt;2&lt;/sup&gt;, Bella Safinda&lt;sup&gt;2&lt;/sup&gt;, Tridiganita Intan Sholikhah&lt;sup&gt;3&lt;/sup&gt;, Bodhi Agustono&lt;sup&gt;4&lt;/sup&gt;, M. Gandul Atik Yuliani&lt;sup&gt;5&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;6&lt;/sup&gt;, Reina Puspita Rahmaniar&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Veterinary Pathology Division, School of Health and Life Sciences, Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Veterinary Medicine, School of Health and Life Sciences, Universitas Airlangga, Indonesia.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Clinic Veterinary Medicine Division, School of Health and Life Sciences, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Animal Husbandry Division, School of Health and Life Sciences, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Basic Veterinary Medicine Division, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Animal Science, Royal University of Bhutan, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Microbiology, Faculty of Veterinary Medicine, Wijaya Kusuma University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Renny Aditya</style></author><author><style face="normal" font="default" size="100%">Budi Santoso</style></author><author><style face="normal" font="default" size="100%">Widjiati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Syzygium Polyanthum (Wight) Walp. Extract on Glutathione, Tumour Necrosis Factor-Alpha, Spdl1, And Degraff Follicles Expression in PCOS Rat Models</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DeGraff follicle count</style></keyword><keyword><style  face="normal" font="default" size="100%">GSH</style></keyword><keyword><style  face="normal" font="default" size="100%">sPDL1</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium polyanthum</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">791-800</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Polycystic ovary syndrome (PCOS) is an endocrine and reproductive disorder affecting 5% to 13% of women of reproductive age. Approximately 80% of women with PCOS underwent infertility cases. Many studies have shown an association between PCOS and low-grade inflammation. Syzygium polyanthum (&lt;em&gt;S. polyanthum&lt;/em&gt;) contains antioxidants and has antiinflammation activity. &lt;strong&gt;Objectives: &lt;/strong&gt;This study aims to investigate the effectiveness of &lt;em&gt;S. polyanthum&lt;/em&gt; leaf on glutathione, tumour necrosis factoralpha (TNF-α), sPDL1, and DeGraff follicle expression in PCOS rat models.&lt;strong&gt; Materials and Methods: &lt;/strong&gt;The female Wistar rats were divided into five groups (n = 5), K0 (normal control), K1 (PCOS group), and three treatment groups which received three different doses of &lt;em&gt;S. polyanthum&lt;/em&gt; extract. The treatment group consisted of PCOS rat models with &lt;em&gt;S. polyanthum&lt;/em&gt; extract supplementation of 150 mg/KgBW (P1), 300 mg/KgBW (P2), and 450 mg/KgBW (P3). &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;S. polyanthum&lt;/em&gt; leaf extract significantly decreased TNF-α expression in the treatment group. The highest TNF-α, GSH, and sPDL1 concentration was found in the P3 group (3.83±0.123, 273.12±12.4 ng/ml, and 3.25 ng/ml, respectively). Moreover, the number of follicles was statistically significant in the P1, P2, and P3 groups (2.0, 3.0, and 3.50, respectively). The number of follicles in the P1, P2, and P3 groups was higher than in the positive control; however, it was lower in the negative control (K0) (p&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;S. polyanthum &lt;/em&gt;extract was significantly effective in decreasing TNF-α expression, as well as a significant increase GSH, sPDL1 and DeGraff foliclle count in PCOS rat model.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">791</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Renny Aditya&lt;sup&gt;1&lt;/sup&gt;, Budi Santoso&lt;sup&gt;2,*&lt;/sup&gt;, Widjiati&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA;&lt;span style=&quot;font-size:10.8333px&quot;&gt; &lt;/span&gt;Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammad Saiful Ardhi</style></author><author><style face="normal" font="default" size="100%">Muhammad Hamdan</style></author><author><style face="normal" font="default" size="100%">Achmad Chusnu Romdhoni</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Thiamine on Serum Glutamate in Ischemic Stroke Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animal model</style></keyword><keyword><style  face="normal" font="default" size="100%">Glutamate</style></keyword><keyword><style  face="normal" font="default" size="100%">Ischemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Stroke.</style></keyword><keyword><style  face="normal" font="default" size="100%">Thiamine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">390-392</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Thiamin or vitamin b1 is a therapy that has been widely used in neurology cases such as alcohol-induced encephalopathy and neuropathy. Thiamin has the ability to penetrate the blood brain barrier so that it is expected to be used as an additional therapy in stroke cases. Stroke is currently an emergency neurology case that causes high mortality and disability. Among the causes is because damage to large areas of the brain will cause the release of neurotransmitters such as glutamate which has excitotoxicity effects to the brain when excessive. &lt;strong&gt;Method: &lt;/strong&gt;This study used animal models of carotid artery occlusion stroke. Divided into 4 groups: control, thiamin dose of 100mg/kg, Thiamin 200mg/kg, and 400mg/kg. Serum glutamate was collected on day 7 post-action. Then evaluated by ELISA method. &lt;strong&gt;Results:&lt;/strong&gt; There was a significant difference in the form of a decrease in the average serum glutamate level between the control and the sample that received a dose of thiamine 200mg/kg and 400mg/kg. &lt;strong&gt;Conclusion: &lt;/strong&gt;High-dose thiamine may be considered as an additional therapy in cases of carotid artery occlusion model stroke.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">390</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Mohammad Saiful Ardhi&lt;sup&gt;1,2&lt;/sup&gt;, Muhammad Hamdan&lt;sup&gt;2,*&lt;/sup&gt;, Achmad Chusnu Romdhoni&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, 60132, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, 60132, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Isra’a JA. Altaee</style></author><author><style face="normal" font="default" size="100%">Aisha A. Qasim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Zamzam Water and ProShieldR Varnish on  Microhardness of Eroded Primary Enamel Teeth Induced by Ironplus Syrup: An In Vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Erosion</style></keyword><keyword><style  face="normal" font="default" size="100%">Ironplus Syrup</style></keyword><keyword><style  face="normal" font="default" size="100%">Microhardness</style></keyword><keyword><style  face="normal" font="default" size="100%">Polarized Light  Microscope</style></keyword><keyword><style  face="normal" font="default" size="100%">ProShieldR Varnish</style></keyword><keyword><style  face="normal" font="default" size="100%">Zamzam water</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1091-1097</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The objective of the current study was to evaluate the erosive adverse effect of paediatric Ironplus syrup and the remineralization effectualness of Zamzam Water and ProShieldR Varnish on microhardness of primary teeth.&lt;strong&gt; Materials and method:&lt;/strong&gt; Forty primary anterior teeth were randomly distributed into five groups, each group has eight samples (N=8) assigned as: group1: control negative, group2: control positive, group3: 5% Sodium Fluoride Varnish, group4: Zamzam water and group5: Zamzam water and 5% Sodium Fluoride Varnish. Excluding the control negative group from them, all samples were immersed in 100ml of Iron&lt;sup&gt;plus&lt;/sup&gt; syrup and agitated for 2 min once a day for 14 days. Then those groups were treated with remineralizing agents of: 5% Sodium Fluoride Varnish for 24 hours, Zamzam water for 30 min every 12 h for 12 days and the combination therapy initiated by Zamzam water then after 30 min, 5% Sodium Fluoride Varnish was applied for 24hrs. Vickers Microhardness test and Polarized Light Microscope were two adopted tests that this study dependent upon. &lt;strong&gt;Results: &lt;/strong&gt;There was a statistically significant difference in microhardness mean values when making a comparison between the baseline and Ironplus tested groups, furthermore ANOVA and Duncan’s Multiple Range test showed that there was a highly significant statistical difference in microhardness mean values among baseline, demineralization and remineralization groups at P-Value ≤ 0.01. &lt;strong&gt;Conclusion:&lt;/strong&gt; The surface microhardness of the primary enamel was reduced owing to the potential erosive efficacy of the used paediatric pharmaceutical preparations. On the other extreme, the previous readings had increased after being treated with remineralizing agents meaning that they have the capacity to battle against erosive potential reaching its highest capability in terms of reminerlization with the combination treatment group.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1091</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Isra’a JA. Altaee&lt;sup&gt;1 &lt;/sup&gt;, Aisha A. Qasim&lt;sup&gt;2&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Directorate of Health, Rusafa, Baghdad, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Preventive Dentistry, College of Dentistry, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bodhi Agustono</style></author><author><style face="normal" font="default" size="100%">Rini Apriliawati</style></author><author><style face="normal" font="default" size="100%">Sunaryo Hadi Warsito</style></author><author><style face="normal" font="default" size="100%">Maya Nurwartanti Yunita</style></author><author><style face="normal" font="default" size="100%">Widya Paramita Lokapirnasari</style></author><author><style face="normal" font="default" size="100%">Sri Hidanah</style></author><author><style face="normal" font="default" size="100%">Emy Koestanti Sabdoningrum</style></author><author><style face="normal" font="default" size="100%">Mohammad Anam Al-Arif</style></author><author><style face="normal" font="default" size="100%">Mirni Lamid</style></author><author><style face="normal" font="default" size="100%">Gandul Atik Yuliani</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Sarasati Windria</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect Supplementation of Microbiota Inoculant in the Early Laying Hens Feed on High Density Lipoprotein (HDL) and Low- Density Lipoprotein (LDL) in Egg Yolk</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">High Density Lipoprotein</style></keyword><keyword><style  face="normal" font="default" size="100%">Laying hens</style></keyword><keyword><style  face="normal" font="default" size="100%">Low Density Lipoprotein</style></keyword><keyword><style  face="normal" font="default" size="100%">Probiotics.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">270-273</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Laying hens (&lt;em&gt;Gallus gallus&lt;/em&gt;) are one of the poultries kept for their eggs. Eggs produced by chickens are used as a source of human food that contains a lot of nutrition and is affordable. Eggs also contain high levels of cholesterol in the yolk, so if consumed in large quantities, they will pose a risk of disease. This study aims to determine the effect of giving probiotics in the early layer laying hen feed on the levels of high-density lipoprotein and low-density lipoprotein in egg yolks. This study has four treatments, namely P1 = control, P2 = feed + AGP, and P3 and P4 = feed + probiotics. The probiotic used is a combination of three bacteria, namely Lactobacillus plantarum, Lactobacillus acidophilus, and Bifidobacterium sp. The sample used in this study was egg yolk, which was collected in the last week of the study. Testing for HDL and LDL levels in egg yolks was carried out using the Quantitative Colorimetric/Fluorometric Determination of HDL and LDL/VLDL method. Testing HDL and LDL levels in this study showed that the administration of probiotics had an effect in the form of increasing HDL levels but did not have an effect in the form of a significant decrease in egg yolk LDL levels during the four-week treatment period in laying hens in the early layer phase, aged 18–22 weeks. The best probiotic dose used among the three probiotic doses is 3 ml/kg of feed.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">270</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bodhi Agustono&lt;sup&gt;1*&lt;/sup&gt;, Rini Apriliawati&lt;sup&gt;1&lt;/sup&gt;, Sunaryo Hadi Warsito&lt;sup&gt;6&lt;/sup&gt;, Maya Nurwartanti Yunita&lt;sup&gt;2&lt;/sup&gt;, Widya Paramita Lokapirnasari&lt;sup&gt;6&lt;/sup&gt;, Sri Hidanah&lt;sup&gt;6&lt;/sup&gt;, Emy Koestanti Sabdoningrum&lt;sup&gt;6&lt;/sup&gt;, Mohammad Anam Al-Arif&lt;sup&gt;6&lt;/sup&gt;, Mirni Lamid&lt;sup&gt;6&lt;/sup&gt;, Gandul Atik Yuliani&lt;sup&gt;3&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;4&lt;/sup&gt;, Sarasati Windria&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Animal Husbandry, School of Health and Life Sciences (SIKIA), Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Pathology Veteriner, School of Health and Life Sciences (SIKIA), Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Basic Veterinary, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Animal Science, Royal University of Bhutan, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biomedical Science, Faculty of Medicine, Universitas Padjajaran, Bandung, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Division of Animal Husbandry, Department of Veterinary Science, Faculty of Veterinary Medicine Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kadek Rachmawati</style></author><author><style face="normal" font="default" size="100%">Rochmah Kurnijasanti</style></author><author><style face="normal" font="default" size="100%">Emy Koestanti Sabdoningrum</style></author><author><style face="normal" font="default" size="100%">Sin War Naw</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of Ketapang (Terminalia cattapa L.) Extract Against Avian Pathogenic Eschericia coli (APEC) Infections in Layer Performance</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Avian Pathogenic Escherichia coli.</style></keyword><keyword><style  face="normal" font="default" size="100%">Food security</style></keyword><keyword><style  face="normal" font="default" size="100%">Layer chicken performance</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminalia cattapa L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">417-422</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aimed to determine the activity of Ketapang extract (&lt;em&gt;Terminalia cattapa&lt;/em&gt; L.) in layers infected with APEC. In vitro study that was conducted dilution methods using Ketapang extract at 5%, 10%, 15%, 20%, 25% and 30% concentrations.&lt;em&gt; In vivo&lt;/em&gt; study was conducted by randomly dividing 20 layers into five treatment groups, four per group. The chickens (except in group P0−) were infected with APEC aged 24 weeks. Then, the treatment was conducted according to the divided groups in one week. The said treatments are P0− (uninfected APEC and unadministered with Ketapang extract), P0+ (infected with APEC and unadministered with Ketapang extract), and P1, P2, and P3 (infected with APEC and administered with Ketapang extract with 5%, 10%, and 20% concentrations, respectively). The data from layers’ performance were analyzed using ANOVA and Duncan’s test. The dilution method (MIC and MBC) exhibited the antibacterial ability of Ketapang extract against APEC at 5% dose. The Ketapang extract administration in layers exhibited improved performance of chickens infected with APEC, with the administration of 10% dose of Ketapang extract showing the best result. In summary, about 10% concentration Ketapang extract can serve as an antibacterial agent and showed the best results in layers infected with APEC.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">417</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kadek Rachmawati&lt;sup&gt;1,*&lt;/sup&gt;, Rochmah Kurnijasanti&lt;sup&gt;1&lt;/sup&gt;, Emy Koestanti Sabdoningrum&lt;sup&gt;2&lt;/sup&gt;, Sin War Naw&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Basic Veterinary Medicine Division, Faculty of Veterinary Medicine, Universitas Airlangga, 60115, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Animal Husbandry Division, Faculty of Veterinary Medicine, Universitas Airlangga, 60115, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry, Myitkyina University, Myitkyina, Myanmar&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maspa Lapui</style></author><author><style face="normal" font="default" size="100%">Wahiduddin</style></author><author><style face="normal" font="default" size="100%">Ida Leida Maria</style></author><author><style face="normal" font="default" size="100%">A Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Ridwan M Thaha</style></author><author><style face="normal" font="default" size="100%">Syamsuar Manyullei</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effectiveness of SI-DINI Mobile App (an Education and Early Detection of Leprosy App) on Changes in Community Behavior</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Attitude</style></keyword><keyword><style  face="normal" font="default" size="100%">Behavior.</style></keyword><keyword><style  face="normal" font="default" size="100%">knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Leprosy</style></keyword><keyword><style  face="normal" font="default" size="100%">SI-DINI App</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">868-872</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Most leprosy case detection in Indonesia is based on passive surveillance. This condition impacts the high number of new cases of leprosy and the disability rate of leprosy. Data from the Ministry of Health of the Republic of Indonesia stated that for 2021, there were 7,201 new cases of leprosy with a disability proportion of 84.6%. The community's reluctance to make early contact is due to low knowledge and fear of stigma. SI-DINI is an android-based application that contains information about leprosy, videos on identifying the characteristics and symptoms of leprosy, and reporting suspected leprosy so that it is hoped that it can change people's behavior in a positive direction. This study aims to see the effectiveness of the SI-DINI App in changing people's behavior. This study used a quasi-experimental design with a pre and post-test design with intervention and control groups. The use of the SI-DINI App has been proven effective in changing people's behavior in terms of knowledge, attitudes and actions. There is a significant increase in the knowledge aspect with&lt;em&gt; p&lt;/em&gt;-value = 0.000 (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,05), the attitude aspect&lt;em&gt; p&lt;/em&gt;-value = 0.000 (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,05), and the action aspect p-value = 0.000 (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,05). It is hoped that the application of education and surveillance for early detection of leprosy (SI-DINI) can be applied on a broader scope and can be used sustainably and in the future.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">868</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maspa Lapui&lt;sup&gt;1,*&lt;/sup&gt;, Wahiduddin&lt;sup&gt;1&lt;/sup&gt;, Ida Leida Maria&lt;sup&gt;1&lt;/sup&gt;, A Arsunan Arsin&lt;sup&gt;1&lt;/sup&gt;, Ridwan M Thaha&lt;sup&gt;2&lt;/sup&gt;, Syamsuar Manyullei&lt;sup&gt;3&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Promotion and Behavioral Sciences, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sulistiawati</style></author><author><style face="normal" font="default" size="100%">Miranda Jemyma Mas’ulun</style></author><author><style face="normal" font="default" size="100%">Anggita Kanza Ramadhany</style></author><author><style face="normal" font="default" size="100%">Afiel Nadhifa Hanafie</style></author><author><style face="normal" font="default" size="100%">Rani Fitri Alfiani</style></author><author><style face="normal" font="default" size="100%">Sarah Evita Husnah</style></author><author><style face="normal" font="default" size="100%">Agnes Ilene Suprapto Puteri</style></author><author><style face="normal" font="default" size="100%">Anisa Novia Mahestari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of the Aedes aegypti Mosquito Vector Control Program in Southeast Asia – A Systematic Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aedes aegypti</style></keyword><keyword><style  face="normal" font="default" size="100%">Dengue</style></keyword><keyword><style  face="normal" font="default" size="100%">Dengue Control Program</style></keyword><keyword><style  face="normal" font="default" size="100%">human and health</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Tropical Disease.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">969-975</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Dengue is still a major vector-borne disease problem in the world. It is caused by infection with the Dengue virus, which can be spread through a vector in the form of the Aedes aegypti mosquito. One of the ways to reduce the incidence of dengue infection is by controlling vectors. &lt;strong&gt;Aim: &lt;/strong&gt;This study aims to analyze the effectiveness of vector control of the Aedes aegypti mosquito on the dengue incidence in Southeast Asia. Methods and findings: This study was a systematic review that examines articles with experimental research designs and cluster randomized controlled trials. The scope of this research area is limited to Southeast Asian countries during 2012-2021. There are 333 articles obtained from two sources: PubMed and ScienceDirect, by using certain keywords. Furthermore, articles were selected based on inclusion and exclusion criteria, so that 31 articles were obtained. A total of 6 articles that met the inclusion criteria were then selected for further analysis. Three journals that discussed the output in the form of the Larva Density Index (LDI) showed a decrease with significant results. Two journals that discussed biological control (Bacillus thuringiensis israelensis) got significant results in decreasing Pupal Density (PD). The two journals on chemical control (permethrin) that discussed the outcome of the presence or absence of IgG seroconversion show insignificant results.&lt;strong&gt; Conclusion&lt;/strong&gt;: All control methods are considered effective. However, among the three vector control methods studied, the control with Bacillus thuringiensis israelensis is the most effective method.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">969</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sulistiawati&lt;sup&gt;1,*&lt;/sup&gt;, Miranda Jemyma Mas’ulun&lt;sup&gt;2&lt;/sup&gt;, Anggita Kanza Ramadhany&lt;sup&gt;2&lt;/sup&gt;, Afiel Nadhifa Hanafie&lt;sup&gt;2&lt;/sup&gt;, Rani Fitri Alfiani&lt;sup&gt;2&lt;/sup&gt;, Sarah Evita Husnah&lt;sup&gt;2&lt;/sup&gt;, Agnes Ilene Suprapto Puteri&lt;sup&gt;2&lt;/sup&gt;, Anisa Novia Mahestari&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Undergraduated student, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Firdaus</style></author><author><style face="normal" font="default" size="100%">Ida Leida Maria</style></author><author><style face="normal" font="default" size="100%">Ansariadi</style></author><author><style face="normal" font="default" size="100%">Andi Zulkifli</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Shanti Riskiyani</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effectiveness of the Si-DBD Application in Increasing the Number of Households in Conducting Periodic Larvae Examination at the Health Center in Bantaeng Regency</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Application</style></keyword><keyword><style  face="normal" font="default" size="100%">DHF.</style></keyword><keyword><style  face="normal" font="default" size="100%">Periodic larva inspection</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">569-574</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Vector-borne diseases, namely DHF, are estimated to infect 100-400 million people each year. Until now there is no specific drug or vaccine for DHF that can be done to avoid or prevent mosquitoes, which focuses on prevention efforts by eradicating mosquito nests. This study aims to see the effectiveness of the application system in carrying out periodic inspections by households. &lt;strong&gt;Method: &lt;/strong&gt;Quasi-experimental research type with design &quot;&lt;em&gt;The&lt;/em&gt; &lt;em&gt;Nonrandomized Control Group Pretest Posttest Design”.&lt;/em&gt; There are 112 samples with a ratio of 1:1 treatment (application system) and control (manual). Data collection using observation sheets (secondary data) and data from larvae inspection results through the application. Seeing the difference before and after the Mc test. Nemar and Chi-Square to see the difference between the treatment and control groups.&lt;strong&gt; Results&lt;/strong&gt;: Periodic larvae inspection by the household before and after manually had no difference, while the system with the application had a significant difference with a value of P=0.000. The comparison between the treatment and control groups with a value of P = 0.000 indicates that there is a difference in the number of households that carry out periodic larva inspections through an application compared to the manual method. The system with the Si-DBD application is simpler, more acceptable, and timelier in carrying out periodic larvae inspections by households with a value of P=0.000. &lt;strong&gt;Conclusion: &lt;/strong&gt;The implementation of periodic larvae inspections that is modeled by an application-based information system via a smartphone has an influence on the number of households that carry out larvae inspections compared to the manual system that is running. Follow-up testing can be carried out on a large scale of household respondents covering the entire work area of the health center and with a cohort research design.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">569</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Firdaus&lt;sup&gt;1,*&lt;/sup&gt;, Ida Leida Maria&lt;sup&gt;2&lt;/sup&gt;, Ansariadi&lt;sup&gt;2&lt;/sup&gt;, Andi Zulkifli&lt;sup&gt;2&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;3&lt;/sup&gt;, Shanti Riskiyani&lt;sup&gt;4&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Masters Program in Field Epidemiology at the Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Nutrition Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Health Promotion and Behavioral Science, Faculty of Public Health, University of Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marisca Evalina Gondokesumo</style></author><author><style face="normal" font="default" size="100%">Yulanda Antonius</style></author><author><style face="normal" font="default" size="100%">Yuana Elly Agustin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectivity of Patch Herbal Mixture Composed of Mangosteen Peel Extract and Bacterial Cellulose for Wound Healing</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bacterial cellulose</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal compound</style></keyword><keyword><style  face="normal" font="default" size="100%">Mangosteen peel extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Patch dressing</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound treatment.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">461-466</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Indonesia has a very abundant production of mangosteen, which places at the 14th largest mangosteen production in the world. High mangosteen production affects the amount of mangosteen peel waste. On the other hand, mangosteen peel has been identified as a rich source in health benefits and has proven to be antibacterial, antifungal, antioxidant, anti-inflammatory, antitumor, and anti-carcinogenic. Traditionally, one of the conventional medicines used in wound dressings or infection medicine. It can be a possibility for patch wound healing development, especially for diabetic ulcers with an open wound, wetness, chronic infections, and high inflammation. This research aims to innovate wound dressings (patch) that contain active compounds from mangosteen peel as herbs with many active compounds to enhance the wound healing process with low toxic side effects. The patch developed from organic material from bacterial cellulose. The research was carried out with the initial process of making patches from bacterial cellulose (BC), then adding mangosteen peel extract as patch dressing with different concentrations (0%, 1%, 2%, 5%, and 10% v/v). Furthermore, the patch was applied to the injured Wistar rat, for 15 days. The wound area was measured using Image-J. The results of measuring the wound area showed significant wound improvement every day at each dose of the mangosteen patch compared with the control group. The optimum dose that appears to be different from the control is 10% v/v mangosteen peel extract which has been able to leave 3% of the wound area on the 15th day.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">461</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Marisca Evalina Gondokesumo&lt;sup&gt;1,*&lt;/sup&gt;, Yulanda Antonius&lt;sup&gt;2&lt;/sup&gt;, Yuana Elly Agustin&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, University of Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Biotechnology, University of Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Chemical Engineering, Faculty of Engineering, University of Surabaya, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Glabela Christiana Pandango</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author><author><style face="normal" font="default" size="100%">Risky Vitria Prasetyo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Magnesium Supplementation on Kidney Function and Phosphate Levels in Children with Chronic Kidney Disease and Hyperphosphatemia: A Double-blind Randomized Clinical Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Children</style></keyword><keyword><style  face="normal" font="default" size="100%">Chronic Kidney Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperphosphatemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney Function.</style></keyword><keyword><style  face="normal" font="default" size="100%">Magnesium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">253-257</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pediatric patients with chronic kidney disease (CKD) who have hyperphosphatemia may experience further deterioration in kidney function. This study aims to investigate the effect of magnesium supplementation on the reduction of phosphate levels and improvement of kidney function in children with CKD and hyperphosphatemia, compared to a placebo. &lt;strong&gt;Methods: &lt;/strong&gt;A randomized, double-blind, placebocontrolled trial was conducted at Pediatric Ward in our setting during March-July 2022. We compared oral magnesium supplementation (6 mg/kg body weight/day for two months) with a placebo in children with CKD and hyperphosphatemia (ages 1-18 years old). Patients who were on dialysis and had serum magnesium levels of &amp;lt;1.6 mg/dL and &amp;gt;2.4 mg/dL, and were allergic to magnesium supplementation were excluded. A paired T-test and the Wilcoxon signed-rank test were used for statistical analysis. &lt;strong&gt;Results:&lt;/strong&gt; We collected 31 children in the experimental group and 29 children in the placebo group. Phosphate levels were decreased in both the magnesium supplementation and placebo groups (5.4 ± 0.9 to 4.8 ± 1.1 mg/dL; &lt;em&gt;p&lt;/em&gt;-value = 0.001 and 5.1 ± 0.6 to 4.3 ± 1.2 mg/dL; &lt;em&gt;p&lt;/em&gt;-value=0.003). However, when compared between groups, the reductions were not significantly different (0.7 vs 0.8; &lt;em&gt;p&lt;/em&gt;-value=0.935). A significant improvement was found in kidney function in both groups using estimated Glomerular Filtration Rate (eGFR) (83.4±25.3 to 118.8±52; &lt;em&gt;p&lt;/em&gt;-value=&amp;lt;0.001 and 86.3±28.1 to 96.9 ± 35.8; p-value=0.004), and the reductions were significantly different (35.4 vs 10.7; &lt;em&gt;p&lt;/em&gt;-value=0.045).&lt;strong&gt; Conclusion: &lt;/strong&gt;Magnesium supplements have considerably lower phosphate levels and markedly improved kidney function in children with CKD and hyperphosphatemia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">253</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Glabela Christiana Pandango&lt;sup&gt;1&lt;/sup&gt;, Bambang Purwanto&lt;sup&gt;2&lt;/sup&gt;, Risky Vitria Prasetyo&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Child Health, Faculty of Medicine Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physiology, Faculty of Medicine Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Francisco Mercedes Infantes Gomez</style></author><author><style face="normal" font="default" size="100%">Natalia Mavila Guzmán Rodríguez</style></author><author><style face="normal" font="default" size="100%">Yolanda Elizabeth Rodríguez de Guzmán</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">Roger Antonio Rengifo-Penadillos</style></author><author><style face="normal" font="default" size="100%">José Gilberto Gavidia-Valencia</style></author><author><style face="normal" font="default" size="100%">Iris Melina Alfaro-Beltrán</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Melissa officinalis essential oil on state and trait anxiety</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Melissa officinalis.</style></keyword><keyword><style  face="normal" font="default" size="100%">State anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Trait anxiety</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">454-460</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Essential oils are complex substances used extensively in aromatherapy and phytotherapy, some of them as anxiety and stress-relieving agents. In order to evaluate the effects of &lt;em&gt;Melissa officinalis&lt;/em&gt; essential oil on state and trait anxiety, this study was conducted. &lt;strong&gt;Methods: &lt;/strong&gt;The essential oil was extracted by steam distillation and the chemical composition was investigated by Gas chromatographymass spectrometry (GC–MS). In addition, a Quasi experimental study with measures at pretest-posttest was conducted, where 58 participants were divided into two groups, a waiting-list (WL) control group, and an experimental group (EG)treated with aromatherapy based on &lt;em&gt;Melissa officinalis&lt;/em&gt; essential oil. The anxiety index was evaluated by State-Trait Anxiety Inventory (STAI). Measures were taken at two times: pretest and posttest. &lt;strong&gt;Results&lt;/strong&gt;: The chemical analysis showed that β-cubebene (26.3%), β-caryophyllene (25.4%) and geranial (12.5%) were de main components. Both state and trait anxiety levels decreased in the experimental group during the posttest phase; however, only state anxiety demonstrated statistically significant differences (p&amp;lt;0.05). A moderate size effect was found for state anxiety (d = 0.799; g= 0.797) with 1-β=0.803; but none for trait anxiety. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Melissa officinalis&lt;/em&gt; essential oil was moderately effective on state anxiety but has no effect on trait anxiety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">454</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado- García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto- Vásquez&lt;sup&gt;2&lt;/sup&gt;, Francisco Mercedes Infantes Gomez&lt;sup&gt;1&lt;/sup&gt;, Natalia Mavila Guzmán Rodríguez&lt;sup&gt;3&lt;/sup&gt;, Yolanda Elizabeth Rodríguez de Guzmán&lt;sup&gt;4&lt;/sup&gt;, Demetrio Rafael Jara- Aguilar&lt;sup&gt;2&lt;/sup&gt;, Roger Antonio Rengifo- Penadillos&lt;sup&gt;2&lt;/sup&gt;, José Gilberto Gavidia-Valencia&lt;sup&gt;2&lt;/sup&gt;, Iris Melina Alfaro-Beltrán&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Medicina. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Escuela de Psicología. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Enfermería. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Instituto Pablo Casals, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ariunjargal Tudev</style></author><author><style face="normal" font="default" size="100%">Sansarkhuyag Enkhtur</style></author><author><style face="normal" font="default" size="100%">Khurelbaatar Luvsan</style></author><author><style face="normal" font="default" size="100%">Odontuya Gendaram</style></author><author><style face="normal" font="default" size="100%">Bold Sharav</style></author><author><style face="normal" font="default" size="100%">Ulambayar Lkhamsuren</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Elucidating the Use of the Plant Paeonia Anomala from the Ancient  Medical Books Kept in Mongolia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1163-1165</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;It is important to determine and study in detail the action of the main chemical and secondary components contained in Paeonia anomala against diseases. In particular, it is of great practical significance to clarify the use of the plant from ancient medical books and scriptures and to determine which of the six main diseases were used in traditional medicine. &lt;strong&gt;Purpose&lt;/strong&gt;: To compare the information of the ancient medical books written by Mongolian doctors and scientists, who wrote about Paeonia anomala L. and to clarify the taste, potency, strength, and quality. &lt;strong&gt;Research materials and methods:&lt;/strong&gt; Research materials: Sumbe khamba Ishbaljir. “gso dpyad bdud rtsi 'i chu rgyun gyi cha lag gi nang tshan gyi sman so so'i mngon brjod dang ngos 'dzin shel dkar me long”. Wooden printing block with Tibetan script. Toin Jambaldorj. “gso byed bdud rtsi'i 'khrul med ngos 'dzin bzo rig me long du rnam par shar ba mdzes mtshar mig rgyan zhes bya ba bzhugs so”. Wooden printing block with Tibetan script. Research methods: Methods of textual analysis for ancient medical books and checklists were used in the study.&lt;strong&gt; Conclusion&lt;/strong&gt;: The use of Paeonia anomala has been enriched with indications for use in traditional Mongolian medicine, Mongolian folk medicine, Russian folk medicine, and Chinese, Japanese, and Korean traditional medicine. In his book &quot;ngos 'dzin shel dkar me long&quot;, the ancient medical scientist Sumbe khamba Ishbaljir wrote the name of the Paeonia anomala plant in Sanskrit as shogandha and in Tibetan as baspru. On the other hand, Toin Jambaldorj noted in his book &quot;mtshar mig rgyan&quot; wrote Paeonia anomala has a warm and equable quality, thus it can create potency. Therefore, it is appropriate to note that this plant in traditional Mongolian medicine is mainly used to treat back pain caused by cold conditions, chronic kidney disease, arthritis, uterine benign tumors, and bladder stones.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1163</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ariunjargal Tudev&lt;sup&gt;1&lt;/sup&gt; , Sansarkhuyag Enkhtur&lt;sup&gt;1&lt;/sup&gt; , Khurelbaatar Luvsan&lt;sup&gt;1&lt;/sup&gt; , Odontuya Gendaram&lt;sup&gt;1&lt;/sup&gt; , Bold Sharav&lt;sup&gt;1,2,*&lt;/sup&gt;, Ulambayar Lkhamsuren&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Mongolian University of Pharmaceutical Sciences, PO-37, Box-59, Ulaanbaatar 18080, Mongolia.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Mongolian Academy of Medical Science, Mongolian Academy of Sciences, PO-46A, Box-171, Ulaanbaatar 14201, Mongolia.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sansarkhuyag Enkhtur</style></author><author><style face="normal" font="default" size="100%">Ariunjargal Tudev</style></author><author><style face="normal" font="default" size="100%">Tungalag Dagdanbazar</style></author><author><style face="normal" font="default" size="100%">Selenge Erdenechimeg</style></author><author><style face="normal" font="default" size="100%">Odontuya Gendaram</style></author><author><style face="normal" font="default" size="100%">Ulambayar Lkhamsuren</style></author><author><style face="normal" font="default" size="100%">Bold Sharav</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Elucidating the Uses of the Plant Veronica Incana from the Ancient Medical Books</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ancient medicinal books.</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional Mongolian medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Veronica Incana</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">901-904</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Medicinal plant research has been successfully carried out in the field of pharmacy and pharmacology in Mongolia, and dozens of research projects are still being carried out. However, there are still fewer studied medicinal plants of practical importance growing in Mongolia. Therefore, there is a need to register and study the ancient medicinal books written by ancient Mongolian doctors about the relatively little-studied&lt;em&gt; Veronica Incana&lt;/em&gt; plant. In addition, taking into account that scientific research on &lt;em&gt;Veronica Incana,&lt;/em&gt; which grows in Mongolia, has not been done in the field of medicine. Therefore, the topic was selected for research in this field.&lt;strong&gt; Purpose:&lt;/strong&gt; Comparing the information of the ancient medical books written by Mongolian doctors and scientists, who wrote about&lt;em&gt; Veronica Incana,&lt;/em&gt; to clarify the taste, power, and quality. Research materials and methods: 1. &lt;strong&gt;Research materials:&lt;/strong&gt; Sumbe khamba Ishbaljir. gso dpyad bdud rtsi 'i chu rgyun gyi cha lag gi nang tshan gyi sman so so'i mngon brjod dang ngos 'dzin shel dkar me long. &lt;em&gt;Wooden printing block&lt;/em&gt; with&lt;em&gt; Tibetan&lt;/em&gt; script. Toin Jambaldorj. gso byed bdud rtsi'i 'khrul med ngos 'dzin bzo rig me long du rnam par shar ba mdzes mtshar mig rgyan zhes bya ba bzhugs so. &lt;em&gt;Wooden printing block&lt;/em&gt; with Tibetan script. 2. Research methods: Methods of textual analysis for ancient books and checklist methods were used in the study. &lt;strong&gt;Conclusion:&lt;/strong&gt; Gandhabhatra plant is used in traditional Mongolian medicinal practices from ancient times, the plant is called &lt;em&gt;Veronica Incana&lt;/em&gt; in Latin. Also called Buural gandbadraa in Mongolian. On the other hand, the traditional medical doctors of China's Inner Mongolia and Tibet use Gandbadraa, the Latin name Gnaphalium affine D. Don. The appearance, shape, and color of the flowers of these two plants are different. According to the research of the source, the main instruction and usage of the plants are the same: to destroy benign tumors, to remove poison, to treat colds, and to stop cough.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">901</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sansarkhuyag Enkhtur&lt;sup&gt;1&lt;/sup&gt;, Ariunjargal Tudev&lt;sup&gt;1&lt;/sup&gt;, Tungalag Dagdanbazar&lt;sup&gt;1&lt;/sup&gt;, Selenge Erdenechimeg&lt;sup&gt;1&lt;/sup&gt;, Odontuya Gendaram&lt;sup&gt;1&lt;/sup&gt;, Ulambayar Lkhamsuren1*, Bold Sharav&lt;sup&gt;1,2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Mongolian University of Pharmaceutical Sciences, PO-37, Box-59, Ulaanbaatar 18080, Mongolia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Mongolian Academy of Medical Science, Mongolian Academy of Sciences, PO-46A, Box- 171, Ulaanbaatar-14201, Mongolia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sardar Hussain</style></author><author><style face="normal" font="default" size="100%">Komal KP</style></author><author><style face="normal" font="default" size="100%">Guruvayoorappan C</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Emilia Sonchifolia-A Critical and Comprehensive Review of its  Diverse Medicinal Potential and Future as Therapeutic</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-tumour</style></keyword><keyword><style  face="normal" font="default" size="100%">Emilia sonchifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1143-1149</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Emilia sonchifolia&lt;/em&gt; (L.) DC, it belongs to the family Asteraceae or Compositae, is conventionally used in ethnomedicine, and acquires various medicinal properties. This plant has been regarded as one of the widespread traditional vegetable salads in Malaysia, Bangladesh, and India. In addendum to its avail as a vegetable, the plant has been documented with several medicinal benefits in the extravagance of night blindness, epilepsy, malaria, asthma, burns, breast abscesses, and inflammatory diseases. On scrutinization of their pharmacological properties, it has been revealed that they possess numerous notable biological properties such as antimicrobial, analgesic, anti-inflammatory, antioxidant, hepatoprotective, antianxiety, and anticataract, as well as anticonvulsant activities. Concrete evidence suggests the presence of potential phytochemicals in this plant with a wide range of unknown applications. In this current review, we discuss the phytochemicals present in the plant &lt;em&gt;Emilia sonchifolia &lt;/em&gt;and emphasize the therapeutic and pharmacological activities reported so far concerning this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1143</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sardar Hussain&lt;sup&gt;1&lt;/sup&gt; , Komal KP&lt;sup&gt;2&lt;/sup&gt; , Guruvayoorappan C&lt;sup&gt;3&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Ph.D. Scholar, R&amp;amp;D Centre, Bharathiar University, Coimbatore 641 046, Tamil Nādu; Assistant Professor, Department of Biotechnology, Government Science College, Chitradurga 577 501, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Biochemistry, Government Science College, Chitradurga 577 501, Karnataka, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Associate Professor, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 011, Kerala, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rina Masadah</style></author><author><style face="normal" font="default" size="100%">Savira Ekawardhani</style></author><author><style face="normal" font="default" size="100%">Ramadani Eka Putra</style></author><author><style face="normal" font="default" size="100%">Dzul Ikram</style></author><author><style face="normal" font="default" size="100%">Muhammad Faruk</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethanolic Extract of Propolis from Tetragonula laeviceps: Selective  Cytotoxicity for MCF-7 Breast Cancer cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7 Breast Cancer Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Proliferation</style></keyword><keyword><style  face="normal" font="default" size="100%">Propolis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1177-1180</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Many patients with breast cancer fail to respond to conventional chemotherapeutic agents; these agents are also associated with numerous adverse events and toxicities. These concerns have led to the ongoing search for natural ingredients with antitumor effects. As such, the aim of this study was to explore the anti-cancer properties of an ethanolic extract of propolis (EEP), a natural product derived from the stingless bee, from &lt;em&gt;Tetragonula laeviceps.&lt;/em&gt; &lt;strong&gt;Methods:&lt;/strong&gt; Bioactive components of EEP were identified by gas chromatography–mass spectrometry (GC–MS) and antioxidant capacity was tested by 2.2-diphenyl1-picrylhydrazyl (DPPH) analysis. Selective cytotoxic actions of EEP on both MCF-7 and Vero cells were then evaluated using the MTT assay. Polyphenols were identified as the major components of EEP from &lt;em&gt;T. laeviceps&lt;/em&gt;. &lt;strong&gt;Results:&lt;/strong&gt; our results indicated that EEP was selectively toxic for human MCF-7 breast cancer cells and had only limited impact on African Green Monkey kidney Vero cells. &lt;strong&gt;Conclusion: &lt;/strong&gt;EEP from T. laeviceps has bioactive components that may selectively inhibit the proliferation of cancer cells. As such, EEP may be useful source material to be used for the development of novel anti-cancer agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1177</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rina Masadah&lt;sup&gt;1&lt;/sup&gt; , Savira Ekawardhani&lt;sup&gt;2&lt;/sup&gt; , Ramadani Eka Putra&lt;sup&gt;3&lt;/sup&gt; , Dzul Ikram&lt;sup&gt;1,4&lt;/sup&gt;, Muhammad Faruk&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biomedical Science, Faculty of Medicine, Padjajaran University, Bandung, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;School of Life Sciences and Technology, Bandung Institute of Technology, Bandung, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Histology, Muslim University of Indonesia, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tizazu Gebre</style></author><author><style face="normal" font="default" size="100%">Bhaskar Rao Chinthapalli</style></author><author><style face="normal" font="default" size="100%">D. S. Vijaya Chitra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Study of the Traditional Use and Maintenance of Medicinal Plant Species and Indigenous Knowledge by the Konso People, Southern Ethiopia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Indigenous knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant species.</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional healers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">719-731</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; For thousands of years, indigenous people have developed their own localized knowledge of plant use, management, and conservation. However, this rich traditional knowledge on plant utilization was not well documented, and most of the indigenous knowledge acquired by the local people was verbally passed from generation to generation. The people of Konso in South Ethiopia use and maintain traditional medicinal plant species, according to their specific ethnobotanical pharmacopeia. &lt;strong&gt;Methods:&lt;/strong&gt; A total of 80 informants aged 25 to 87 years old were chosen (10 individuals of which 5 healers and 5 clients) from the 24 key informants were identified representing 6 from each kebele. The present study explores the unique indigenous knowledge that enables the community to identify medicinal plants, prepare medications, and then apply the cures used to treat a variety of human diseases as dangers to their long-term use. This study was carried out from September 2018 to July 2019. &lt;strong&gt;Results&lt;/strong&gt;: Some medicinal plant species are more popular than others &lt;em&gt;Lepidium sativum, Hagenia abyssinica&lt;/em&gt; and &lt;em&gt;Allium sativum &lt;/em&gt;were cited by all the 80 informants for their medicinal value. Powdered form was directly used from 40.0% of the medicinal plant species, while 51.4% are chewed, extracted with water, and / or with butter (17.1% each) and 8.6% are extracted with local beer. Of the herbal remedies used in the study area, 68.6% were applied orally and 31.4% were applied externally. Roots are the parts mostly used (35.7%), followed by leaves (32.9%), combination of parts (18.6%), root bark (5.7%), fruit (2.9%), in that order, respectively. It was known that highest source of the medicinal plants was the forest (45.3%). &lt;strong&gt;Conclusions&lt;/strong&gt;: Home gardens and agro forests together contribute 41.86% of the medicinal plants. This study was undertaken to bring awareness towards community-based in-situ and ex-situ conservation actions, attracting younger generations to grab the indigenous knowledge from the parents and ancestors and strengthening home gardens and other agro-forestry systems be used as repositories of medicinal plant species and alternative conservation sites to preserve the traditional medicinal plant species of the study area.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">719</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tizazu Gebre&lt;sup&gt;1&lt;/sup&gt;, Bhaskar Rao Chinthapalli&lt;sup&gt;2,*&lt;/sup&gt;, D. S. Vijaya Chitra&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, College of Natural Sciences, Arba Minch University, P.O. Box 21, Arba Minch, ETHIOPIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Life Sciences, University of the West Indies, Mona, Kingston 7, St Andrews, JAMAICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maulana Yusuf Alkandahri</style></author><author><style face="normal" font="default" size="100%">Mally Ghinan Sholih</style></author><author><style face="normal" font="default" size="100%">Nitya Nurul Fadilah</style></author><author><style face="normal" font="default" size="100%">Maya Arfania</style></author><author><style face="normal" font="default" size="100%">Surya Amal</style></author><author><style face="normal" font="default" size="100%">Dedy Frianto</style></author><author><style face="normal" font="default" size="100%">Lina Aliyani Mardiana</style></author><author><style face="normal" font="default" size="100%">Diany Astuti</style></author><author><style face="normal" font="default" size="100%">Dadang Muhammad Hasyim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antidiarrheal, Antispasmodic, and Antisecretory Activities of Extract and Fractions of Castanopsis costata Leaves in Animal Models</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animal models</style></keyword><keyword><style  face="normal" font="default" size="100%">Castanopsis costata</style></keyword><keyword><style  face="normal" font="default" size="100%">Diarrhea</style></keyword><keyword><style  face="normal" font="default" size="100%">North Sumatra.</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">31-37</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The use of traditional medicinal plants &lt;em&gt;Castanopsis costata &lt;/em&gt;in the management of diarrhea is an ancient practice in North Sumatra, Indonesia, but its safety and efficacy have not been examined scientifically in animal models. Therefore, this study aims to determine the antidiarrheal effect of &lt;em&gt;C. costata&lt;/em&gt; leaf extract and fractions&lt;em&gt; in vivo&lt;/em&gt;. &lt;strong&gt;Methods: &lt;/strong&gt;The antidiarrheal activity was evaluated against animal models of diarrhea induced by castor oil, charcoal meal, and entero-pooling test. The extract group received doses of 25, 50, 100, and 200 mg/kg, while the fraction groups was treated with WFCC, EAFCC, and nHFCC, in doses of 50 and 100 mg/kg, respectively. The negative control received 10 mL/kg of the dissolving vehicle, while the positive was treated with loperamide 3 mg/kg.&lt;strong&gt; Results&lt;/strong&gt;: The results showed that EECC doses of 200 mg/kg, WFCC, and EAFCC at 50 and 100 mg/kg, respectively significantly delayed the onset of diarrhea, while WFCC and EAFCC at 100 mg/kg significantly reduced the amount of wet feces output and total feces output. In addition, only WFCC and EAFCC (at 50 and 100 mg/kg, respectively) significantly reduced the mean weight of wet feces and total feces. The percentage of maximum diarrhea inhibition was observed at the EAFCC dose of 100 mg/kg. Based on the charcoal meal test results, only EAFCC significantly inhibited the distance traveled by charcoal meal and reduced the peristaltic index at a dose of 100 mg/kg, while the percentage decrease in gastrointestinal motility was 46.87%. Similarly, in the entero-pooling test, WFCC and EAFCC significantly reduced the volume and weight of intestinal contents at a dose of 100 mg/kg, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results confirm that the extract and fractions of &lt;em&gt;C. costata&lt;/em&gt; have antidiarrheal activity. Therefore, this study provides scientific support for the traditional use of &lt;em&gt;C. costata&lt;/em&gt; in treating diarrhea.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">31</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maulana Yusuf Alkandahri&lt;sup&gt;1,*&lt;/sup&gt;, Mally Ghinan Sholih&lt;sup&gt;2&lt;/sup&gt;, Nitya Nurul Fadilah&lt;sup&gt;3&lt;/sup&gt;, Maya Arfania&lt;sup&gt;1&lt;/sup&gt;, Surya Amal&lt;sup&gt;1&lt;/sup&gt;, Dedy Frianto&lt;sup&gt;1&lt;/sup&gt;, Lina Aliyani Mardiana&lt;sup&gt;1&lt;/sup&gt;, Diany Astuti&lt;sup&gt;1&lt;/sup&gt;, Dadang Muhammad Hasyim&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Health Sciences, Universitas Singaperbangsa Karawang, Karawang, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Health Sciences, Universitas Perjuangan Tasikmalaya, Tasikmalaya, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Diploma Program of Pharmacy, Karsa Husada Garut College of Health Sciences, Garut, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Asriani Usman</style></author><author><style face="normal" font="default" size="100%">Irwandy</style></author><author><style face="normal" font="default" size="100%">Noer Bahry Noor</style></author><author><style face="normal" font="default" size="100%">Alimin Maidin</style></author><author><style face="normal" font="default" size="100%">Fridawaty Rivai</style></author><author><style face="normal" font="default" size="100%">Indrabayu</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Electronic Medical Record System in Outpatient Dr. Wahidin Sudirohusodo Makassar Central General Hospital in 2022</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Electronic Medical Record System</style></keyword><keyword><style  face="normal" font="default" size="100%">Hot-Fit</style></keyword><keyword><style  face="normal" font="default" size="100%">Outpatient.</style></keyword><keyword><style  face="normal" font="default" size="100%">System Evaluation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">423-427</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The Electronic Medical Record System in Indonesia is currently a concern of the government of the Republic of Indonesia by requiring every health facility including hospitals in Indonesia to implement an Electronic Medical Record System. To find out that this system is beneficial for health services in hospitals, an evaluation is needed. This study aims to evaluate the Electronic Medical Record System that has been running in the Outpatient of Dr. Wahidin Sudirohusodo Makassar Central General Hospital from a user perspective using the Human Organization Fit Model. The type of research used is quantitative using an analytical observational design with a cross sectional study approach. The sample in this study were users of electronic medical records in the Outpatient Department of Dr. Wahidin Sudirohusodo Makassar Central General Hospital, totaling 174 respondents. Hypothesis testing in this study using path analysis. The results of this study indicate that technology has a direct and significant effect on humans (&amp;lt;0,001) &amp;lt;0,05. Technology has a direct and significant effect on the organization (&amp;lt;0,001) &amp;lt;0,05. Humans have a direct and significant effect on the organization (&amp;lt;0,001) &amp;lt;0,05. Human has a direct and significant effect on benefits (&amp;lt;0,001) &amp;lt;0,05. Organization has a direct and significant effect on benefits (&amp;lt;0,001) &amp;lt;0,05. Technology has an indirect effect on benefits through people (ρ Value 0,007 &amp;lt; 0,05, path coefficient = 0,179). Technology has no indirect effect on benefits through organizations (ρ Value 0,051 &amp;gt; 0,05). This means that humans as intermediaries from technology to benefits have a significant effect while organizations as intermediaries from technology to benefits have an insignificant effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">423</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Asriani Usman&lt;sup&gt;1&lt;/sup&gt;, Irwandy&lt;sup&gt;1&lt;/sup&gt;, Noer Bahry Noor&lt;sup&gt;1&lt;/sup&gt;, Alimin Maidin&lt;sup&gt;1&lt;/sup&gt;, Fridawaty Rivai&lt;sup&gt;1&lt;/sup&gt;, Indrabayu&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Hospital Administration Study Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Informatics, Faculty of Engineering, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Environmental Health Department, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bhairav Kumar Pathak</style></author><author><style face="normal" font="default" size="100%">Kamlesh M. Palandurkar</style></author><author><style face="normal" font="default" size="100%">Meenakshi Singh</style></author><author><style face="normal" font="default" size="100%">Anshuman Trigunayat</style></author><author><style face="normal" font="default" size="100%">Amit Singh</style></author><author><style face="normal" font="default" size="100%">Reena Giri</style></author><author><style face="normal" font="default" size="100%">Kiran Rajendra Giri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of In vivo Analgesic and Anti-inflammatory Activity of Oroxyulum indicum, Baicalein, Chrysin with Phytochemical Analysis and Molecular Docking Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Baicalein</style></keyword><keyword><style  face="normal" font="default" size="100%">Chrysine</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Oroxylum indicum</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF alpha.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">811-822</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: &lt;em&gt;Oroxyulum indicum &lt;/em&gt;(OIE) is a native medicinal plant that has been widely employed in Ayurvedic medicine for thousands of years. Though studies have been published citing the analgesic and anti-inflammatory activity of &lt;em&gt;Oroxyulum indicum&lt;/em&gt; and chrysin and Baicalein, there has been no comparative study comparing their activittes and confirming them with molecular docking results. Molecular docking study of two phytochemicals Chrysin (PubChem CID 5281607) and Baicalein (PubChem CID 5281605) into the active sites of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Evaluation and validation of Anti-inflammatory and Analgesic effects of a methanolic extract of the stem bark of Oroxylum indicum and its two constituents Chrysin and Baicalein in Charles foster rats with analysis of the phytoconstituent of &lt;em&gt;Oroxyulum indicum &lt;/em&gt;through HRMS analysis. &lt;strong&gt;Methodology: &lt;/strong&gt;UHPLC-HRMS/MS analyses were performed on a Dionex Ultimate 3000 RS Series UHPLC system combined with a Q Exactive Plus High-Resolution Accurate Mass Spectrometry System. Hot plate and Tal flick model are used for screening of analgesic activity. TNF-alpha and IL-6 inflammatory markers were examined. Carrageenan model is used for antiinflammatory analysis. &lt;strong&gt;Result: &lt;/strong&gt;Interesting results has been obtained in the docking studies of Chrysin and Baicalein with COX-1 (PDB ID: 1EQG). The hydrogen bond interaction established between the Chrysin and Baicalein with the important amino acid, includes Arg 120, Tyr 355, Ser 530, Met 522 (Figure 1). The binding free energy of the Chrysin and Baicalein with target COX-1 was found to be -7.88 and -7.26 Kcal/mol. &lt;strong&gt;Conclusion:&lt;/strong&gt; There is marked reduction in the TNF Alpha expression in the OIE group which is followed by Baicalein and Chrysine. The Baicalein group shows the most marked cumulative increase in reaction time for tail flick among all the groups of the intervention group followed by Chrysine and OIE.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">811</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bhairav Kumar Pathak&lt;sup&gt;1&lt;/sup&gt;, Kamlesh M. Palandurkar&lt;sup&gt;2&lt;/sup&gt;, Meenakshi Singh&lt;sup&gt;3&lt;/sup&gt;, Anshuman Trigunayat&lt;sup&gt;4&lt;/sup&gt;, Amit Singh&lt;sup&gt;5&lt;/sup&gt;, Reena Giri&lt;sup&gt;6&lt;/sup&gt;, Kiran Rajendra Giri&lt;sup&gt;7,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Junior Resident, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department of Biochemistry, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Medicinal Chemistry Department, Faculty of Ayurveda, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Pharmacology, GMC, Akola, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Associate Professor, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sharada L. Deore</style></author><author><style face="normal" font="default" size="100%">Anjali A. Kide</style></author><author><style face="normal" font="default" size="100%">Bhushan A. Baviskar</style></author><author><style face="normal" font="default" size="100%">Somshekhar S. Khadabadi</style></author><author><style face="normal" font="default" size="100%">Bhavana A Shende</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Neuroprotective Efficacy of Indian Shankhpushpi Varieties in Alzheimer’s disease – North Vs South</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alzheimer’s disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Dementia</style></keyword><keyword><style  face="normal" font="default" size="100%">Scopolamine</style></keyword><keyword><style  face="normal" font="default" size="100%">Scopoletin.</style></keyword><keyword><style  face="normal" font="default" size="100%">taraxerol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">372-377</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Shankhpushpi is a well-known Ayurvedic memory enhancing medicine associated with controversy. Among the various varieties, Convolvulus pleuricaulis and Clitorea ternatia are widely used in commercial memory enhancing formulations under the name of Shankhpushpi. Convolvulus pleuricaulis is recognized as true shankhpushpi in North side of India, however in southern part of India, Clitorea ternatia is accepted as Shankhpushpi. &lt;strong&gt;Objectives:&lt;/strong&gt; The present study aims to compare neuroprotective efficacy of &lt;em&gt;C. pleuricaulis &lt;/em&gt;and &lt;em&gt;C. ternatea&lt;/em&gt; by &lt;em&gt;in vitro&lt;/em&gt;, &lt;em&gt;in vivo &lt;/em&gt;methods and establish scientifically validated data to choose appropriate shankhpushpi variety for commercial use. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Both herbs were extracted in the Soxhlet apparatus with 70% ethanol for 5 - 6 hours at 60 - 65̊ C. The presence of neuroprotective principles - taraxerol and scopoletin in extracts was confirmed by the Thin Layer Chromatography. The preliminary screening for neuroprotective efficacy of extracts was done by in vitro free radical scavenging, Acetyl cholinesterase enzyme inhibition and LOX enzyme level estimation. Invivo study of extracts included behavioral assessment of adult rats by Y maze, Morris water maze using scopolamine induced Alzheimer’s disease like model. &lt;strong&gt;Result: &lt;/strong&gt;Extracts of both &lt;em&gt;C. pleuricaulis&lt;/em&gt; and &lt;em&gt;C. ternatea &lt;/em&gt;significantly scavenged free radicals, inhibited acetyl cholinesterase and LOX enzyme in vitro. But in in-vivo study, significant retention of spatial and working memory was observed in rats administered with &lt;em&gt;C. pleuricaulis&lt;/em&gt; as compared to&lt;em&gt; C. ternatea.&lt;/em&gt; &lt;strong&gt;Conclusion: &lt;/strong&gt;&lt;em&gt;C. pleuricaulis &lt;/em&gt;more significantly shields against memory loss and dementia by reducing oxidative stress, inflammation, and memory impairment. Hence should be used in commericial neuroprotective formulation as chief source of Shankhpushpi instead of &lt;em&gt;C. ternatea.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">372</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sharada L. Deore, Anjali A. Kide*, Bhushan A. Baviskar, Somshekhar S. Khadabadi, Bhavana A Shende&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Government College of Pharmacy, Kathora Naka, Amravati -444601, Maharshtra, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Karmilasari</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Darmawansyah</style></author><author><style face="normal" font="default" size="100%">Muh. Syafar</style></author><author><style face="normal" font="default" size="100%">Indar</style></author><author><style face="normal" font="default" size="100%">Citrakesumasari</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the Economic Impact of Implementing National  Health Insurance (JKN) on Hospitals at RSUD Tenriawaru Kab. bone</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Compensation</style></keyword><keyword><style  face="normal" font="default" size="100%">Financial</style></keyword><keyword><style  face="normal" font="default" size="100%">Financing</style></keyword><keyword><style  face="normal" font="default" size="100%">Income</style></keyword><keyword><style  face="normal" font="default" size="100%">JKN</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1156-1162</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The National Health Insurance Program (JKN) through the Social Security Administering Body has been running since January 1 2014, the Tenriawaru Regional General Hospital in Bone Regency is one of the hospitals under the auspices of the local government that works closely with BPJS Kesehatan. The Bone Regency Government has registered 237,381 people into the National Health Insurance (JKN) program. In general, this study aims to analyze the economic impact of the implementation of the National Health Insurance (JKN) on hospital income, hospital financing and financial compensation for hospital employees at Tenriawaru Hospital, Kab, Bone. This study uses a qualitative descriptive research method that aims to obtain an in-depth evaluation study on evaluating the economic impact of the implementation of the National Health Insurance (JKN) program on hospitals. The informants in this study totaled 5 people consisting of the Head of Finance Subdivision, the JKN case mix officer, the Head of Service Subdivision, the Head of HR Subdivision and the Head of Public Relations Subsection. The results of the study show that the implementation of the National Health Insurance (JKN) program has an impact on hospital income. The implementation of JKN provides great benefits for the hospital. the implementation of the National Health Insurance (JKN) program also has an impact on hospital financing, JKN covers hospital operational costs, JKN claims have their respective portions for hospital human resources, drug resources and BHP in hospitals. The implementation of the National Health Insurance (JKN) program has no impact on the financial compensation of employees in hospitals, salaries, bonuses and semi-annual incentives that employees get have no effect on the implementation of JKN in service hospitals that get a portion each for the operational needs of the hospital not for employee financial compensation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1156</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Karmilasari&lt;sup&gt;1&lt;/sup&gt; , Sukri Palutturi&lt;sup&gt;2,&lt;/sup&gt;*, Darmawansyah&lt;sup&gt;3&lt;/sup&gt; , Muh. Syafar&lt;sup&gt;4&lt;/sup&gt; , Indar&lt;sup&gt;5&lt;/sup&gt; , Citrakesumasari&lt;sup&gt;6&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Masters Student of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Health Promotion, Faculty of Public Health, Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Science Nutrition, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suresh Chandra Akula</style></author><author><style face="normal" font="default" size="100%">Pritpal Singh</style></author><author><style face="normal" font="default" size="100%">Prikshat Kumar Angra</style></author><author><style face="normal" font="default" size="100%">Gagandeep Singh Cheema</style></author><author><style face="normal" font="default" size="100%">Anup Sharma</style></author><author><style face="normal" font="default" size="100%">Mohd Farhan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An Evaluation of the Effectiveness of Pharmacognosy Research and a Pharmaceutical Resource Management in Hospitals</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Data envelopment analysis (DEA)</style></keyword><keyword><style  face="normal" font="default" size="100%">Efficiency</style></keyword><keyword><style  face="normal" font="default" size="100%">Hospitals</style></keyword><keyword><style  face="normal" font="default" size="100%">India</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy research</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacy</style></keyword><keyword><style  face="normal" font="default" size="100%">SBM model</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1224-1229</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This research paper aims to evaluate the relative efficacy of pharmacognosy research on the top 40 tertiary hospitals and its pharmacy in India according to Newsweek's 2021 ranking. &lt;strong&gt;Purpose:&lt;/strong&gt; India's pharmaceutical market is now estimated to be worth $50 billion. India is a significant pharmaceutical exporter, reaching more than 200 nations with its exports. This study will help to identify whether the pharma industry is working efficiently in selected Indian hospitals or not. Thus, to create a bench marking for the hospital pharmacies in India. &lt;strong&gt;Design/methodology/approach:&lt;/strong&gt; Data for the study came from public and private hospitals' official websites, financial records, and government notifications. Cross- sectional data analyses were done using a Slack-Based model and data envelopment analysis (DEA). STATA was the software used to scrutinize the results effectively. &lt;strong&gt;Results: &lt;/strong&gt;Thirteen hospital pharmacies out of a total of 40 are judged to be relatively technically efficient overall, according to the research. The findings of the slack analysis demonstrate that government hospitals and pharmacies are better able to handle slack and effectively manage input and output. &lt;strong&gt;Conclusion: &lt;/strong&gt;The researchers also set upped a benchmarking hospital both for private and government healthcare settings for pharmacognosy research. Thus, it can be utilized for the betterment of the pharmacies.&amp;nbsp;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1224</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Suresh Chandra Akula&lt;sup&gt;1,*&lt;/sup&gt;, Pritpal Singh&lt;sup&gt;1&lt;/sup&gt; , Prikshat Kumar Angra&lt;sup&gt;2&lt;/sup&gt; , Gagandeep Singh Cheema&lt;sup&gt;1&lt;/sup&gt; , Anup Sharma&lt;sup&gt;1&lt;/sup&gt; , Mohd Farhan&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Mittal School of Business, Lovely Professional University, Phagwara, Punjab 144001, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of computer applications, Lovely Professional University, Phagwara, Punjab 144001, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ns. Grace C Sipasulta</style></author><author><style face="normal" font="default" size="100%">Indah Nur Imamah</style></author><author><style face="normal" font="default" size="100%">Genevieva E Tanihatu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Experiences and Expectations of Post-Partum Mothers Toward Psychosocial Nursing Services for Mothers Who Have Experienced Postpartum Blues in City of Balikpapan</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Baby Blues</style></keyword><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Postpartum</style></keyword><keyword><style  face="normal" font="default" size="100%">Psychosocial Services.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">471-478</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;After giving birth, the mother feels happy to finally be able to meet her beloved baby. However, some mothers actually do not feel happy but appear feelings of sadness, anxiety, and depression after giving birth. As many as 30-75 present of women can experience baby blues after giving birth and one in seven women can experience postpartum depression. Health Education needs to be improved and Nutrition for pregnant women needs attention Micronutrients prevent postpartum depression so that babies are born healthy. Based on the above problems that are still untouched by promotion and prevention health for women overcome the level of emotional anxiety from pregnancy to post-delivery which can be experienced by mothers from mild, moderate to severe. Nurses play a key role related to providing physical and psychological care to support the improvement of the mother's condition towards more positive. Mothers are at risk for natural emotional problems requiring someone to be able to give him an understanding of the process he is going through and help him to remain in a more stable condition. This study involved seven participants with diverse characteristics and provided an overview and the high need of postpartum mothers to feel comfortable so that their coping efforts could be achieved so that they did not experience emotional problems after giving birth.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">471</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ns. Grace C Sipasulta&lt;sup&gt;1&lt;/sup&gt;, Indah Nur Imamah&lt;sup&gt;1*&lt;/sup&gt;, Genevieva E Tanihatu&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;East Kalimantan Health Polytechnic D-III Nursing Program Balikpapan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Univercity of Persada Indonesia Y.A.I, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ridwan Mochtar Thaha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Experimental Study of Development Food Safety Booklet using  Local Language</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Booklet</style></keyword><keyword><style  face="normal" font="default" size="100%">Cadre</style></keyword><keyword><style  face="normal" font="default" size="100%">Food Safety</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1132-1135</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;To prevent food poisoning in Indonesia, it is necessary to have health promotion efforts in the field of food safety using appropriate media. Therefore, this study aims to develop food safety information media, namely local language booklets. For this reason, this study examines the validity and feasibility of local language food safety booklet. The research was conducted in Gorontalo Province from August to October 2022. The development of booklet is done by validating and trial. Validation was carried out using the DELPHI technique with experts in a qualitative descriptive research type. After that, a trial of the booklet was carried out with 20 Village Food Safety Cadres by distributing trial questionnaires and short interviews. Data analysis in this study used content analysis techniques. The results of the validity and feasibility of the local language food safety booklet show that the booklet is very feasible to use. Furthermore, it is hoped that further research can examine the effectiveness of using booklets to convey food safety messages to the wider community.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1132</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ridwan Mochtar Thaha*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Health Promotion and Behavioral Science, Hasanuddin University of Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Daya Banyu Bening</style></author><author><style face="normal" font="default" size="100%">Reni Prastyani</style></author><author><style face="normal" font="default" size="100%">Nurwasis</style></author><author><style face="normal" font="default" size="100%">Evelyn Komaratih</style></author><author><style face="normal" font="default" size="100%">Ismi Zuhria</style></author><author><style face="normal" font="default" size="100%">Hari Basuki Notobroto</style></author><author><style face="normal" font="default" size="100%">Dyah Fauziah</style></author><author><style face="normal" font="default" size="100%">Chrismawan Ardianto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Expressions of Matrix Metalloproteinase-3 and Tissue Inhibitor Metalloproteinase-1 in Corneal Tissue Post Alkali Burn Treated with Topical Medroxyprogesterone Acetate and Doxycycline</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Corneal alkali burn</style></keyword><keyword><style  face="normal" font="default" size="100%">Doxycycline.</style></keyword><keyword><style  face="normal" font="default" size="100%">Medroxyprogesterone acetate</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">553-557</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;This study aims to investigate the effects of topical Medroxyprogesterone acetate (MPA) and Doxycycline in inhibiting the expression of MMP-3 and TIMP-1 in ocular alkali burn models in animals. &lt;strong&gt;Methods: &lt;/strong&gt;A total of 18 New Zealand Rabbits were divided into 3 groups based on their post-alkali-burn treatment: PBS (G1/ control group), topical Doxycycline 1mg/ml (G2), and topical MPA 1% (G3). Alkali burn models were made by exposing 1N NaOH solution to the central cornea for 30 seconds. MMP-3 and TIMP-1 expression were evaluated using immunohistochemistry after 14 days of treatment. &lt;strong&gt;Results:&lt;/strong&gt;&lt;strong&gt; &lt;/strong&gt;Statistically significant differences in the mean MMP-3 expression were found between the three groups (p=0.010). There was a significant difference in MMP-3 expression between the control group with MPA (p=0.017) and Doxycycline (p=0.028) but was not found between the MPA and Doxycycline groups (p=1,000). The mean differences in TIMP-1 expression between the three treatment groups were statistically significant (p=0.005), with a significant difference between the control group with Doxycycline (p=0.022) and MPA (p=0.007). There was no significant difference in TIMP-1 expression between the Doxycycline and MPA groups (P=1,000). &lt;strong&gt;Conclusion: &lt;/strong&gt;This study indicated that topical administration of Doxycycline or MPA in ocular alkali burn reduces the expression of MMP-3 and TIMP-1.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">553</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Daya Banyu Bening&lt;sup&gt;1&lt;/sup&gt;, Reni Prastyani&lt;sup&gt;1,*&lt;/sup&gt;, Nurwasis&lt;sup&gt;1&lt;/sup&gt;, Evelyn Komaratih&lt;sup&gt;1&lt;/sup&gt;, Ismi Zuhria&lt;sup&gt;1&lt;/sup&gt;, Hari Basuki Notobroto&lt;sup&gt;2&lt;/sup&gt;, Dyah Fauziah&lt;sup&gt;3&lt;/sup&gt;, Chrismawan Ardianto&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Ophthalmology, Dr. Soetomo General Academic Hospital / Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biostatistics and Population, Faculty of Public Health, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meilla Dwi Andrestian</style></author><author><style face="normal" font="default" size="100%">Rizal Damanik</style></author><author><style face="normal" font="default" size="100%">Faisal Anwar</style></author><author><style face="normal" font="default" size="100%">Nancy Dewi Yuliana</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extract of Torbangun (Coleus amboinicus Lour) Leaves Inhibits  the Expression of PEPCK and G6Pase in Streptozotocin-Induced  Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">G6Pase</style></keyword><keyword><style  face="normal" font="default" size="100%">hyperglycemia</style></keyword><keyword><style  face="normal" font="default" size="100%">PEPCK</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Torbangun</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1116-1120</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to analyze the anti-hyperglycemic activity of Torbangun leaf extract (TLE) in hyperglycemic rats by observing its effect on blood glucose levels and &lt;em&gt;PEPCK &lt;/em&gt;and &lt;em&gt;G6Pase&lt;/em&gt; gene expression. &lt;strong&gt;Method:&lt;/strong&gt; This post-test-controlled group design study used a completely randomized design (CRD). Seven rats were separated as a normal group (N) and other rats were injected with streptozotocin (STZ). Hyperglycemia was characterized by fasting blood glucose (FBG) &amp;gt;126 mg/dl. Hyperglycemic rats were divided into three groups: H-IM (control drug metformin hydrochloride dose 62.5 mg/kg BW), H-IT (TLE dose 620mg/kg BB), and NG (negative control, hyperglycemic rats). Rats were given intervention for 14 days.&lt;strong&gt; Result:&lt;/strong&gt; The results showed a significant difference between initial and final FBG of the HI-IM group (p = 0.002, α = 0.01) and the H-IT group (p = 0.005, α = 0.01) and effect on the key gene expression of gluconeogenesis in the liver. The H-IT group showed a decrease in PEPCK gene expression 0.80 times and decreased G6Pase gene expression by 0.65 times compared to NG group. &lt;strong&gt;Conclusion:&lt;/strong&gt; The findings suggested the administration of TLE in STZ-induced hyperglycemic rats was able to reduce blood sugar levels and was involved in inhibiting the expression of PEPCK and G6Pase expression genes in the liver.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1116</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Meilla Dwi Andrestian&lt;sup&gt;1,*&lt;/sup&gt;, Rizal Damanik&lt;sup&gt;2,3&lt;/sup&gt;, Faisal Anwar&lt;sup&gt;2&lt;/sup&gt; , Nancy Dewi Yuliana&lt;sup&gt;4&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Nutrition, Polytechnic of Health Ministry of Health Banjarmasin, Banjarbaru, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Community Nutriton, Faculty of Human Ecology, IPB University, Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Southeast Asian Food and Agricultural Science and Technology (SEAFAST) Center Bogor, IPB University, Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Food Science, Faculty of Agricultural Agricultural Engineering and Technology, IPB University, Bogor, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Ema Dewanti</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Antioxidant activity, Total Phenols and Total Flavonoids on Arginase Inhibitory Activity on Plants of Genus Sterculia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Arginase</style></keyword><keyword><style  face="normal" font="default" size="100%">Enzyme</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterculia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">322-328</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The genus of Sterculia has the main compound of phenol and flavonoids. The secondary metabolites which have an arginase inhibitory activities were phenol and flavonoids. The aim of this study was to investigate the arginase inhibitory activity from genus Sterculia. The Plant of&lt;em&gt; Sterculia: Sterculia rubiginosa Zoll.&lt;/em&gt; ex Miq., &lt;em&gt;Sterculia comosa &lt;/em&gt;(Wall) Roxb., &lt;em&gt;Sterculia parkinsonii&lt;/em&gt; F. Muell, &lt;em&gt;Sterculia macrophylla &lt;/em&gt;Vent,&lt;em&gt; Sterculia Stipulata Korth. &lt;/em&gt;The simplisia were leaves and woods. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The simplisia were extracted with n-hexane, ethyl acetate and methanol. The ethyl acetate and methanol extract determined the arginase inhibition activity. The active extracts as an arginase inhibitory, determined the total flavonoids, total phenols and antioxidant activity, and the chemical content. &lt;em&gt;Sterculia comosa&lt;/em&gt; (Wall) Roxb., Sterculia macrophylla Vent, &lt;em&gt;Sterculia Stipulata Korth.&lt;/em&gt;, have arginase inhibitory activity. &lt;strong&gt;Results: &lt;/strong&gt;The ethyl acetate extracts of Sterculia Stipulata leaves is an active extract. The methanol extract which have an arginase inhibitor activity were Sterculia comosa (Wall) Roxb. wood and leaves, Sterculia macrophylla Vent., wood and leaves, &lt;em&gt;Sterculia stipulata&lt;/em&gt; &lt;em&gt;Korth., &lt;/em&gt;wood, and leaves. The methanol extract of &lt;em&gt;Sterculia comosa &lt;/em&gt;(Wall) Roxb. Woods has the highest content of total phenols, antioxidant activity, and arginase inhibitory activity. The methanol extract of &lt;em&gt;Sterculia macrophylla &lt;/em&gt;Vent. has the highest content of total flavonoids, but this extract as an arginase inhibitory activity more lower than &lt;em&gt;Sterculia comosa.&lt;/em&gt; The active extract as an arginase activity was methanol extract of &lt;em&gt;Sterculia comosa &lt;/em&gt;(Wall) Roxb. &lt;strong&gt;Conclusion:&lt;/strong&gt; The total phenols were more contributed for the response of the arginase inhibitory activity much more than antioxidant activity and total flavonoids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">322</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rini Prastiwi&lt;sup&gt;1,*&lt;/sup&gt;, Berna Elya&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;3,4&lt;/sup&gt;, Ema Dewanti&lt;sup&gt;1&lt;/sup&gt;, Rani Sauriasari&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy and Science Muhammadiyah Prof. Dr. Hamka University, 1340 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy Indonesia University, Depok 16424, West Java, INDONESIA. 4Research Centre for Chemistry - National Research and Innovation Agency (BRIN), INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sampurna</style></author><author><style face="normal" font="default" size="100%">Andin Putri Aulia</style></author><author><style face="normal" font="default" size="100%">Eka Puji Liashari</style></author><author><style face="normal" font="default" size="100%">Happy Hapsari</style></author><author><style face="normal" font="default" size="100%">Syafrie Sahrul Gibran</style></author><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Bajakah Tea Extract (Spatholobus littoralis Hassk) on High Density Lipoprotein, Triglyceride and Total Cholesterol Levels in Male Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HDL levels</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperlipidemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Pirated tea extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Total cholesterol.</style></keyword><keyword><style  face="normal" font="default" size="100%">Triglycerides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">687-691</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Hyperlipidemia is the high concentrations of low-density lipoprotein, cholesterol, and triglycerides in the blood. Furthermore, hyperlipidemia has a risk factor for cardiovascular complications through atherosclerosis that triggers coronary heart disease (CHD). &lt;em&gt;Spatholobus littoralis&lt;/em&gt; Hassk known as Bajakah tea is a plant with high antioxidant content and acts as an HMG-CoA reductase inhibitor to suppress lipid metabolism disorders, increase HDL levels, and reduce triglycerides and total cholesterol. Experimental and posttest control group design methods were used to obtain 24 male Wistar rats. Furthermore, the experimental animals were randomly divided into 4 groups, namely K1 (normal rats), K2 (hyperlipidemia rats), K3 (hyperlipidemic rats + pirated tea extract dose 9 mg/200gramBW/day), and K4 (hyperlipidemic rats + simvastatin dose 0.18 mg/200 gBW/day). The study was conducted at the Center for Food and Nutrition Studies Laboratory, Gajah Mada University, Yogyakarta. Data levels of HDL, triglycerides, and total cholesterol were analyzed using the One Way Anova test and LSD post hoc to determine between groups. The results showed that an increase in triglyceride and total cholesterol and a decrease in HDL levels in the K2 group compared to the K1. Triglyceride and total cholesterol decreased in groups K3 and K4 compared to K2, and HDL levels increased in groups K3 and K4 compared to K2. Meanwhile, the results of the analysis obtained p value &amp;lt;0.05. This study concluded that the administration of Bajakah tea extract at a dose of 9 mg/200gram BW/day for 14 days increase HDL, reduce triglyceride and total cholesterol levels (p&amp;lt;0,05).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">687</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sampurna&lt;sup&gt;1,*&lt;/sup&gt;, Andin Putri Aulia&lt;sup&gt;1&lt;/sup&gt;, Eka Puji Liashari&lt;sup&gt;2&lt;/sup&gt;, Happy Hapsari&lt;sup&gt;2&lt;/sup&gt;, Syafrie Sahrul Gibran&lt;sup&gt;2&lt;/sup&gt;, Siti Thomas Zulaikhah&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Sultan Agung Islamic University (UNISSULA), INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Student of the Faculty of Medicine, Sultan Agung Islamic University (UNISSULA), INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Sultan Agung Islamic University (UNISSULA), INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Omar Khaled Al-Mobideen</style></author><author><style face="normal" font="default" size="100%">Ali Abdallah Alqudah</style></author><author><style face="normal" font="default" size="100%">Ahmed Al-Mustafa</style></author><author><style face="normal" font="default" size="100%">Fuad Alhawarat</style></author><author><style face="normal" font="default" size="100%">Hussam Mizher</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Crataegus aronia on the Biochemical Parameters in Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Crataegus aronia</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">587-595</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Crataegus aronia&lt;/em&gt; is widely known for its antioxidant, anti-inflammatory, and hypolipidemic properties, and it has traditionally been used to treat cardiovascular disorders. This study aimed to evaluate the impact of &lt;em&gt;Crataegus aronia&lt;/em&gt; extract on the liver enzyme markers, blood glucose levels, lipid profiles, and kidney function biomarkers as well as hematological parameters in induced diabetic rats. Male Wistar rats were divided into seven groups: normal Control; Diabetic; and Diabetic animals treated with two doses of &lt;em&gt;Crataegus aronia&lt;/em&gt; extract (5 and 10mg/kg) (DM + extract), Control treated with the extract ( 5 and 10mg/ kg) and induced diabetic treated with insulin. Streptozotocin (STZ)-induced diabetic rats (50 mg/kg, ip)and normal were orally administrated with &lt;em&gt;Crataegus aronia&lt;/em&gt; extract once a day for 4 weeks. At the end of the experiment, the biochemical and hematological parameters were measured in all groups. Also, the phytochemicals and antioxidant activity of the &lt;em&gt;Crataegus aronia&lt;/em&gt; extract were evaluated. According to findings, the total phenols, total flavonoid, and flavonol contents were 538.3 mg Galic acid equivalent /g extract, 149.3 mg Rutin equivalent / g extract, and 79.3 mg Rutin equivalent / g extract), respectively. The antioxidant activity according to 2,2-diphenyl-2-picrylhydrazyl (DPPH) IC&lt;sub&gt;50&lt;/sub&gt; and ferric reducing antioxidant power (FRAP) assays were 28.02 μg/ml and in the range of 0.273 – 0.960 μmol Fe&lt;sup&gt;+2&lt;/sup&gt;/g dw, respectively. &lt;em&gt;Crataegus aronia &lt;/em&gt;extract significantly (p &amp;lt;0.05) affects red blood cells, hemoglobin, hematocrit, white blood cells, lymphocytes, and platelets values. Also, &lt;em&gt;Crataegus aronia&lt;/em&gt; had a significant (P &amp;lt; 0.05) effect on serum biochemical parameters, including glucose, total proteins, albumins, triglycerides, creatinine, bilirubin, and serum aspartate aminotransferase (AST). However, &lt;em&gt;Crataegus aronia&lt;/em&gt; treatment had no significant effects (p &amp;lt; 0.05) on serum alanine aminotransferase, alkaline phosphatase, and cholesterol levels.&lt;em&gt; Crataegus aronia &lt;/em&gt;exerts antioxidant activity and significantly improves the biochemical and hematological biomarkers in induced diabetic rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">587</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Omar Khaled Al-Mobideen&lt;sup&gt;1&lt;/sup&gt;, Ali Abdallah Alqudah&lt;sup&gt;2&lt;/sup&gt;, Ahmed Al- Mustafa&lt;sup&gt;3*&lt;/sup&gt;,Fuad Alhawarat&lt;sup&gt;1&lt;/sup&gt;, Hussam Mizher&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of paramedics, Prince Al-Hussein bin Abdullah II Academy of Civil Protection, Al- Balqa' Applied University, JORDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Applied Biology, Tafila Technical University, JORDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Mutah University, JORDAN. 4Department of Basic Medical Sciences, Kulliyyah of Pharmacy, Pahang, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hartono</style></author><author><style face="normal" font="default" size="100%">B Suryawati</style></author><author><style face="normal" font="default" size="100%">Y Sari</style></author><author><style face="normal" font="default" size="100%">A Avicena</style></author><author><style face="normal" font="default" size="100%">Maryani</style></author><author><style face="normal" font="default" size="100%">C Sukmagautama</style></author><author><style face="normal" font="default" size="100%">H Apriningsih</style></author><author><style face="normal" font="default" size="100%">L Shofiyah</style></author><author><style face="normal" font="default" size="100%">RGH Novika</style></author><author><style face="normal" font="default" size="100%">NJ Wahidah</style></author><author><style face="normal" font="default" size="100%">NY Rahmawati</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">L Sumarno</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Curcumin and Virgin Coconut Oil Towards Cytokines Levels in COVID-19 Patients at Universitas Sebelas Maret Hospital, Surakarta, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">216-225</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; To date, no specific therapeutic drug has been approved to target SARS-CoV-2. Hence, it remains a major challenge to decide what potential therapeutic regimens to treat COVID-19 patients. This study aims to investigate curcumin and virgin coconut oil (VCO) effects on cytokine levels (IL-1β, IL-2, IL-6, IL-18, TNF-α, and IFN-β) in COVID-19 patients. &lt;strong&gt;Methods&lt;/strong&gt;: This study was a single-center, controlled trial with a parallel Arm or a Randomized Clinical trial design. A total of sixty COVID-19 patients admitted to the Universitas Sebelas Maret Hospital, Surakarta, Indonesia, were divided into two groups. The first group, consisting of 30 patients, was treated with Azithromycin 500 mg + Oseltamivir 2×75 mg + Hydroxychloroquine 400 mg/day for 5 days. The second group, comprising 30 patients, was treated with Azithromycin 500 mg + Oseltamivir 2×75 mg + Hydroxychloroquine 400 mg/day for 5 days, added with VCO 30 mL and curcumin 3×1 g/day for 21 days. The cytokine profiles of the serum samples were analyzed by the enzyme-linked immunosorbent assay (ELISA) on days 1, 14, and 21. &lt;strong&gt;Results:&lt;/strong&gt; Our study showed that the second group had a significant reduction in IL-1β, IL-2, IL-6, TNF-α, and IFN-β levels after being treated with standard therapy added with curcumin and VCO on day 21 (p&amp;lt;0.05).&lt;strong&gt; Conclusion:&lt;/strong&gt; These results suggested that curcumin and VCO might benefit the treatment of COVID-19 patients.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; COVID-19, Curcumin, Cytokines, Virgin coconut oil.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">216</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hartono&lt;sup&gt;1,2*&lt;/sup&gt;, B Suryawati&lt;sup&gt;3&lt;/sup&gt;, Y Sari&lt;sup&gt;4&lt;/sup&gt;, A Avicena&lt;sup&gt;2&lt;/sup&gt;, Maryani&lt;sup&gt;3&lt;/sup&gt;, C Sukmagautama&lt;sup&gt;2&lt;/sup&gt;, H Apriningsih&lt;sup&gt;2&lt;/sup&gt;, L Shofiyah&lt;sup&gt;2&lt;/sup&gt;, RGH Novika&lt;sup&gt;5&lt;/sup&gt;, NJ Wahidah&lt;sup&gt;5&lt;/sup&gt;, NY Rahmawati&lt;sup&gt;6&lt;/sup&gt;, ANM Ansori&lt;sup&gt;7&lt;/sup&gt;, L Sumarno&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universitas Sebelas Maret (UNS) Teaching Hospital, Surakarta, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Microbiology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Parasitology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Midwifery Study Program, Faculty of Medicine, Universitas Sebelas Maret, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Doctoral Program of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;National Research and Innovation Agency, Jakarta, Indonesia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Paulus Anthony Halim</style></author><author><style face="normal" font="default" size="100%">Wachid Putranto</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Omega-3 Rich Fish Oil on the Kidney Changes in Mice Induced by Azoxymethane and Dextran Sodium Sulfate</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Azoxymethane</style></keyword><keyword><style  face="normal" font="default" size="100%">Dextran sodium sulfate</style></keyword><keyword><style  face="normal" font="default" size="100%">Fish oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Omega-3</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">259-266</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: The study aimed to investigate the effect of omega-3 rich fish oil to kidney of mice induced by Azoxymethane (AOM) and DSS using histopathology parameters. &lt;strong&gt;Method:&lt;/strong&gt; The experimental mice were induced using 10 mg/kg AOM and 2% DSS for 2 weeks randomly allocated randomly into four groups as follows;&lt;strong&gt; Control Group:&lt;/strong&gt; mice that not received fish oil, Low Dose Group: mice that received 1.5 mg/day fish oil, Medium Dose Group: mice that received 3 mg/day fish oil, and High Dose Group: mice that received 6 mg/day fish oil. The omega-3 rich fish oil was given for 12 weeks. &lt;strong&gt;Result:&lt;/strong&gt; The administration of high dose omega-3 rich fish oil was able to reduced necrosis and inflammation foci compared to the control group (p&amp;lt;0.05). Furthermore, the administration of low, medium, and high dose omega-3 rich fish oil was able to significantly reduced vascular edema and cell degeneration foci (p&amp;lt;0.05). The administration of medium and high dose of omega-3 rich fish oil were able to reduce the amount of fibrosis foci compared to the control group (p&amp;lt;0.05) compared to the control group. &lt;strong&gt;Conclusion: &lt;/strong&gt;The result suggested anti-nephrotoxic effect of omega-3 rich fish oil in mice induced by azoxymethane and DSS.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">02</style></accession-num><section><style face="normal" font="default" size="100%">259</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Paulus Anthony Halim&lt;sup&gt;3&lt;/sup&gt;, Wachid Putranto&lt;sup&gt;4,*&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2,5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Doctoral Programme Study of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Drug Development Research Cluster, Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Jakarta, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Nephrology, Department of Internal Medicine, Dr. Moewardi General Hospital, Faculty of Medicine, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sari Yunita Sukmawati Noer</style></author><author><style face="normal" font="default" size="100%">Mahrus A Rahman</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Pomegranate Extract On N-Terminal Pro Brain Natriuretic Peptide and Asymmetric Dimetylarginine Levels in Children with Pulmonary Artery Hypertension in Acyanotic Congenital Heart Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asymmetric dimetylarginine</style></keyword><keyword><style  face="normal" font="default" size="100%">Congenital heart disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Pulmonary artery hypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Punica Granatum.</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminal pro brain natriuretic peptide</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">898-904</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Pulmonary arterial hypertension (PAH) is one of the complications due to acyanotic congenital heart disease. New treatment approach using natural ingredients from plants has been demonstrated &lt;em&gt;in vitro &lt;/em&gt;to prevent and improve vascular remodeling in PAH. Objective: This study aimed to analyze the effect of pomegranate extract on N-terminal pro brain natriuretic peptide (NT pro BNP) and asymmetric dimethylarginine (ADMA) levels in children with PAH in acyanotic CHD. &lt;strong&gt;Method: &lt;/strong&gt;This study is a double-blind, quasi-experimental text with pre-test, post-test, and control group approach to children aged one month to 10 years old in Outpatient Department of Pediatric Cardiology Department/Pediatrics Department RSUD Dr. Soetomo in the period of February-October 2022, alongside met the inclusion criteria. Data were analyzed using Wilcoxon and Mann-Whitney test with 95% CI. &lt;strong&gt;Result: &lt;/strong&gt;The study cohort included 15 subjects in the placebo group and 15 subjects in pomegranate extract group. The study was predominantly female (53,3%) with a mean age of each group, i.e., placebo group was 49 months, and pomegranate extract group was 58 months. The mean level of NT pro-BNP in the pomegranate extract group was 29.31 ± 33.55 ng/L (p= 0.008) and its mean ADMA level was 5619 ± 6166 ng/L (p= 0.173). As for the difference of NT pro-BNP and ADMA level changes after the intervention did not show a significant difference (p-0,330; p=0,885, respectively).&lt;strong&gt; Conclusion: &lt;/strong&gt;No significant effect towards NT pro- BNP and ADMA levels found with giving pomegranate extract to children with PAH due to acyanotic CHD.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">898</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sari Yunita Sukmawati Noer&lt;sup&gt;1&lt;/sup&gt;, Mahrus A Rahman&lt;sup&gt;1,*&lt;/sup&gt;, Budi Utomo&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pediatrics Department, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Public Health, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Raja Yasmin Khalilah</style></author><author><style face="normal" font="default" size="100%">E Zuraidah</style></author><author><style face="normal" font="default" size="100%">Ari Estuningtyas</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Pomegranate Peel Ethanol Extract to TNF-α Expression of Mice Colonic Epithelial Cells Induced Using Dextran Sodium Sulfate (DSS)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Colonic epithelial cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Dextran sodium sulfate</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice.</style></keyword><keyword><style  face="normal" font="default" size="100%">Pomegranate peel ethanol extract</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">480-488</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The conventional drugs for inflammatory bowel disease (IBD) have many side effects that impact patient’s quality of life, leading to the emergence of alternative therapies such as pomegranate peel ethanol extract (PPE). This study aims to investigate the anti-inflammatory effect of PPE by observing TNF-α expression in mice induced chronic inflammation of the colon using dextran sodium sulfate (DSS). &lt;strong&gt;Methods:&lt;/strong&gt; 28 Swiss Webster mice samples were taken and divided into five groups, the control group (6 mice), the negative control group (5 mice), the group that was given DSS and aspirin (6 mice), the group was given DSS and a high dose of PPE (5 mice), and the group was given DSS and a low dose of PPE (6 mice). In mice, distal colonic tissue was taken and then stained immunohistochemically against TNF-α and observed with light microscopy at 400x magnification, and TNF-α expression was assessed using the H-Score. &lt;strong&gt;Results:&lt;/strong&gt; TNF-α expression was significantly lower in the group given a high dose of PPE than the negative control group (p &amp;lt;0.05), with mean rank scores of 3.00 and 8.00. There was no significant difference between the group given PPE with a high dose and aspirin (p&amp;gt; 0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; TNF-α expression in colonic epithelial cells of mice given DSS decreased upon treatment of a high dose of PPE, indicating a mechanism of decreasing inflammation. PPE also has the same effect as aspirin in reducing inflammation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">01</style></accession-num><section><style face="normal" font="default" size="100%">480</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1-4, &lt;/sup&gt;Raja Yasmin Khalilah&lt;sup&gt;5&lt;/sup&gt;, E Zuraidah&lt;sup&gt;1,*&lt;/sup&gt;, Ari Estuningtyas&lt;sup&gt;6&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2,7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmacology and Therapeutic, Faculty of Medicine Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Trisnawati Mundijo</style></author><author><style face="normal" font="default" size="100%">Yurnadi Hanafi Midoen</style></author><author><style face="normal" font="default" size="100%">Franciscus D. Suyatna</style></author><author><style face="normal" font="default" size="100%">Agung Eru Wibowo</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Seahorse Extract (Hippocampus comes L.) on Caspase-3 and TUNEL assay in Rats After Depot Medroxyprogesterone Acetate Induction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apoptotic</style></keyword><keyword><style  face="normal" font="default" size="100%">Caspase-3</style></keyword><keyword><style  face="normal" font="default" size="100%">DMPA</style></keyword><keyword><style  face="normal" font="default" size="100%">Seahorse</style></keyword><keyword><style  face="normal" font="default" size="100%">TUNEL assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">253-258</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Seahorse (&lt;em&gt;Hippocampus spp&lt;/em&gt;) is marine fish and have pharmacological activity, such as an antiinflammatory, antioxidative, antifatigue and improve the fertility. Depot medroxyprogesterone acetate (DMPA) is a contraception drug for male and affect the endocrine system by inhibiting pituitary gonadotropin with reduce testosterone levels in 12 weeks. There are limited studies reported the effects seahorse extract (SE) on Caspase-3 and TUNEL assay in rats induced by DMPA. Thirty &lt;em&gt;Sprague-Dawley &lt;/em&gt;(SD) male rats that were induced by 1.25mg/kgbw DMPA in 0 and 12 weeks. The animals were randomly into five groups, following: aquadest (G1), CMC 1% (G2), SE dose of 150 mg/kgbw (G3), SE dose of 225 mg/kgbw (G4), SE dose of 300 mg/kgbw (G5). The rats were gavage every day from seven until week eighteen. On the last week, we taken the right and left testis to observed the apoptotic on Caspase-3 and TUNEL assay. Apoptotic marker was observed through immunohistochemistry from testicular tissue and analysed with plugin ImageJ IHC profiler, which is H-score as the results. Data were analysed using One-Way ANOVA and Bonferroni’s post hoc tests. The SE decrease the Caspase-3 and TUNEL assay expression in rats induced by DMPA until eighteen weeks, with dose 150 mg/kgbw given the significant difference with p=0.028; &amp;lt;0.05 and p=0.000; &amp;lt;0.01. These results suggest that SE decreased germ cells apoptotic in DMPA induced rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">01</style></accession-num><section><style face="normal" font="default" size="100%">253</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Trisnawati Mundijo&lt;sup&gt;1,2&lt;/sup&gt;, Yurnadi Hanafi Midoen&lt;sup&gt;3,*&lt;/sup&gt;, Franciscus D. Suyatna&lt;sup&gt;4&lt;/sup&gt;, Agung Eru Wibowo&lt;sup&gt;5&lt;/sup&gt;, Kusmardi Kusmardi,&lt;sup&gt;1,6-8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Programme Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Muhammadiyah Palembang, Jl. KH Bhalqi No. 13 Ulu, Palembang, 30263, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;National Research and Innovation Agency, Indonesia, Puspiptek Street, Serpong, 15314, South Tangerang, Banten, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amung Logam Saputro</style></author><author><style face="normal" font="default" size="100%">Uliy Ba’sin Syadid</style></author><author><style face="normal" font="default" size="100%">Rimayanti</style></author><author><style face="normal" font="default" size="100%">Suherni Susilowati</style></author><author><style face="normal" font="default" size="100%">Ragil Angga Prastiya</style></author><author><style face="normal" font="default" size="100%">Bodhi Agustono</style></author><author><style face="normal" font="default" size="100%">Fauzan Mumtazi</style></author><author><style face="normal" font="default" size="100%">Marifatunnisa’romadhona</style></author><author><style face="normal" font="default" size="100%">Anastasya</style></author><author><style face="normal" font="default" size="100%">Muhammad Riesta Farhan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Vitamin C and E Supplementation and Combination of Both in Egg Yolk Tris Diluter on the Quality of Sapera Goat Spermatozoa in the 5 °C Cooling Process</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">5˚C Cooling Process</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality of Spermatozoa</style></keyword><keyword><style  face="normal" font="default" size="100%">Sapera Goat</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin C</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin E</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">661-665</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study was aimed to determine the effect of vitamin C, E supplementation and both combination in the egg yolk tris diluent on the quality of Sapera goat spermatozoa in 5˚C cooling process. The samples were fresh semen collected from Sapera goat. It was divided into four different treatment groups. The control treatment or P0 contained semen sample + egg yolk tris diluent, P1 contained semen sample + egg yolk tris diluent + vitamin C 0,9 mg/ml, P2 contained semen sample + egg yolk tris diluent + vitamin E 1 mg/ml, P3 contained semen sample + egg yolk tris diluent + vitamin C 0,9 mg/ml + vitamin E 1 mg/ ml. The least decrease of spermatozoa motility, viability and membrane integrity was found in P3, which was significantly different to P0 (p&amp;lt;0,05). However, P1 and P2 did not show significant difference in the results of motility and viability evaluation (p&amp;gt;0,05). It can be concluded that the combination of vitamin C and E supplementation can be an optimal antioxidants supplement in egg yolk tris diluent on the quality of Sapera goat spermatozoa in 5˚C cooling process.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">661</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amung Logam Saputro&lt;sup&gt;2,5,*&lt;/sup&gt;, Uliy Ba’sin Syadid&lt;sup&gt;1&lt;/sup&gt;, Rimayanti&lt;sup&gt;3&lt;/sup&gt;, Suherni Susilowati&lt;sup&gt;3&lt;/sup&gt;, Ragil Angga Prastiya&lt;sup&gt;3&lt;/sup&gt;, Bodhi Agustono&lt;sup&gt;4&lt;/sup&gt;, Fauzan Mumtazi&lt;sup&gt;2,5,&lt;/sup&gt; Marifatunnisa’romadhona&lt;sup&gt;2,5&lt;/sup&gt;, Anastasya&lt;sup&gt;2,5,&lt;/sup&gt; Muhammad Riesta Farhan&lt;sup&gt;2,5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Bachelor of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Veterinary Clinic, Department of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Animal Nutrition, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Veterinary Clinic, School of Health and Life Sciences, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thapakorn Chumphon</style></author><author><style face="normal" font="default" size="100%">Yaowanoot Promnuan</style></author><author><style face="normal" font="default" size="100%">Sujinan Meelai</style></author><author><style face="normal" font="default" size="100%">Saran Promsai</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effective Enzyme-Producing Bacteria Isolated from Diversified Thai Rice and Native Thai Bees (Cavity Nesting Honey Bees) and their Potential for Production of Protease Enzymes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bacteria</style></keyword><keyword><style  face="normal" font="default" size="100%">Bees</style></keyword><keyword><style  face="normal" font="default" size="100%">Biodiversity</style></keyword><keyword><style  face="normal" font="default" size="100%">Protease Enzyme</style></keyword><keyword><style  face="normal" font="default" size="100%">Rice.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">506-517</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Thailand is one of the most bio-diversified countries in Southeast Asia, especially regarding plants, animals and microbes that impact directly on human and animal life. &lt;strong&gt;Methods:&lt;/strong&gt; Of the 201 bacterial isolates that were screened from Thai rice and bees in Ratchaburi and Chiang Mai provinces, Thailand, most were classified in the genus &lt;em&gt;Bacillus&lt;/em&gt;. &lt;strong&gt;Result:&lt;/strong&gt; From the morphological test and 16S ribosomal DNA sequence study, three strains, &lt;em&gt;Bacillus flexus&lt;/em&gt; KRptI_S2, &lt;em&gt;Microbacterium paraoxydans&lt;/em&gt; C13HN2 and &lt;em&gt;Paenibacillus hunanensis&lt;/em&gt; KRrb_T2, could produce amylase and protease enzyme and non-hemolytic activity at higher temperature. The highest enzymatic activity of protease was produced by &lt;em&gt;P. hunanensis &lt;/em&gt;KRrb_T2 (378.9967±1.335 U.mL-1) at 36 h. &lt;strong&gt;Conclusion:&lt;/strong&gt; In summary, the bacteria from Thai rice and bees could be potential suitable sources of protease production for development by the food and beverage industries globally.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">04</style></accession-num><section><style face="normal" font="default" size="100%">506</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Thapakorn Chumphon&lt;sup&gt;1&lt;/sup&gt;, Yaowanoot Promnuan&lt;sup&gt;2&lt;/sup&gt;, Sujinan Meelai&lt;sup&gt;3&lt;/sup&gt;, Saran Promsai&lt;sup&gt;1,2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Program of Bioproducts Science, Department of Science, Faculty of Liberal Arts and Science, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Microbiology, Department of Science, Faculty of Liberal Arts and Science, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Microbiology, Faculty of Science, Silpakorn University, Sanam-Chandra Palace Campus, Nakhon Pathom 73000, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Novianti Supriatna</style></author><author><style face="normal" font="default" size="100%">Nurjati Chairani Siregar</style></author><author><style face="normal" font="default" size="100%">Erni Hernawati Purwaningsih</style></author><author><style face="normal" font="default" size="100%">Linda Erlina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Acalypha indica L. Extract on Inflammatory Response in The Pathogenesis of Nonalcoholic Fatty Liver Disease: An Overview of TLR9, NFκB and TNFα Expression in Hepatocytes and Macrophages of Sprague-Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acalypha indica L.</style></keyword><keyword><style  face="normal" font="default" size="100%">NAFLD</style></keyword><keyword><style  face="normal" font="default" size="100%">NFκB</style></keyword><keyword><style  face="normal" font="default" size="100%">TLR9</style></keyword><keyword><style  face="normal" font="default" size="100%">TNFα</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">710-719</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Complications of non-alcoholic fatty liver disease (NAFLD) include 67% of the criteria for metabolic syndrome.&lt;em&gt; Acalypha indica&lt;/em&gt; L., (AI) which is one of a herbal plant had been known as anti-oxidant and anti-inflammatory effects. The effect of AI for therapy investigated by looking of the immune defense mechanisms. This researched was assessed by molecular docking approached on TLR9, NFκB, TNFα expression and liver morphological changes. &lt;strong&gt;Methods:&lt;/strong&gt; Animal models of steatohepatitis were collected from high-fructose and cholesterol diet (HFCD) of Sprague-Dawley rats for 12 weeks and followed by therapy for 8 weeks. There were 5 groups from twenty five researched rats, include normal group (K1), HFCD group (K2), HFCD group supplemented with 400 mg &lt;em&gt;Acalypha indica &lt;/em&gt;L. (K3), combination between 400 mg AI+Gemfibrozil (Gem) 31 mg (K4) and Gem 31 mg/kg (K5) in kgBW, respectively. &lt;strong&gt;Results:&lt;/strong&gt; The results of molecular docking were carried out by assessing the interaction between hydrogen molecules of AI compounds and amino acid residues in TLR9, NFκB, TNFα. Morphological changes were assessed by scoring system. Statistical analyzed used Kruskall Wallis with post hoc Mann Whitney test continued by Spearman correlation test.&lt;strong&gt; Conclusion&lt;/strong&gt;: The molecular docking analysis showed that, an alkaloid compounds were found besides the flavonoid compounds that can bind to the binding pocket of inflammatory markers with the best binding energies. Other compounds, there are dasycarpidan-1- methanol, acetate (ester), fenofibrate and quinine. Supplementation of AI would reduced hypertrophy (p=0.031), macrovesicular steatosis (p=0.018), inflammation foci (p=0.005) and also decreased of TLR9 (p=0.009), NFκB (p=0.009), TNFα (p=0.009) expression, but not as good as the combination of AI+Gem.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">710</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Novianti Supriatna&lt;sup&gt;1&lt;/sup&gt;, Nurjati Chairani Siregar&lt;sup&gt;2&lt;/sup&gt;, Erni Hernawati Purwaningsih&lt;sup&gt;3*&lt;/sup&gt;, Linda Erlina&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Varidianto Yudo</style></author><author><style face="normal" font="default" size="100%">Widjiati</style></author><author><style face="normal" font="default" size="100%">Harianto Notopuro</style></author><author><style face="normal" font="default" size="100%">Yulianto Listiawan</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Purwo Sri Rejeki</style></author><author><style face="normal" font="default" size="100%">Prawesty Diah Utami</style></author><author><style face="normal" font="default" size="100%">Aryati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Golden Sea Cucumber Extract (Stichopus hermanni) on Hyphae, Neutrophils and TNF-α in BALB/c Mice Inoculated with C. albicans Intravaginally</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Candida vaginitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyphae</style></keyword><keyword><style  face="normal" font="default" size="100%">Neutrophils</style></keyword><keyword><style  face="normal" font="default" size="100%">Stichopus hermanni extract</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">278-285</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Candidal vaginitis&lt;/em&gt; is an inflammatory disease that caused mainly by &lt;em&gt;Candida albicans&lt;/em&gt;. Yeast transitions to filamentous hyphae considered the most important virulence factor. Neutrophils are the first line of defense of the immune system, but in patients with&lt;em&gt; Candidal vaginitis&lt;/em&gt; the recruitment of neutrophils into the vaginal lumen is positively correlated with symptoms of the disease. This is supported by the release of proinflammatory cytokines such as TNF-α. Standard treatment is considered less effective in relieving symptoms, so other alternative/adjunctive treatments are needed. Golden sea cucumber (Stichopus hermanni) extract has been widely studied, especially for anti-fungal and anti-inflammatory. This study aims to analyze the mechanism of decreasing number of hyphae and neutrophils, and proinflammatory cytokine TNF-α in BALB/c mice inoculated intravaginally with &lt;em&gt;C. albicans &lt;/em&gt;after administration of golden sea cucumber extract (&lt;em&gt;S. hermanni&lt;/em&gt;).&lt;strong&gt; Methods: &lt;/strong&gt;Experimental research uses a post-test only control group design. The experimental unit consisted of 36 BALB/c mice that were inoculated intravaginally with &lt;em&gt;C. albicans &lt;/em&gt;and divided into 4 groups, group that did not receive treatment (K-), group that received standard treatment fluconazole (K+), group that received treatment with golden sea cucumber extract (&lt;em&gt;S. hermanni&lt;/em&gt;) (P1) and group that received standard treatment with fluconazole plus extract of golden sea cucumber (&lt;em&gt;S. hermanni&lt;/em&gt;) (P2). The hyphae and neutrophils number were seen microscopically on vaginal mucosal tissue. Cytokine levels of TNF-α were seen from the ELISA blood samples. &lt;strong&gt;Results: &lt;/strong&gt;Results showed from the vaginal mucosal tissue of mice, there was significant difference in the number of hyphae (p = 0.001) between groups and no significant difference in the number of neutrophils (p = 0.070) between groups. From the blood serum of mice, there were significant differences in TNF-α levels (p=0.001) between groups. From the path analysis obtained a significant relationship from the number of hyphae to the number of neutrophils (p = 0.034) and the number of neutrophils to TNF-α levels (p = 0.021). The strength of the pathway from number of hyphae to number of neutrophils (β= 0.354) and number of neutrophils to TNF-α levels (β= 0.382) with positive interactions all. &lt;strong&gt;Conclusion:&lt;/strong&gt; In summary, the administration of &lt;em&gt;S. hermanni&lt;/em&gt; extract was able to reduce the number of hyphae, neutrophils and TNF-α levels through the hyphae, neutrophil and TNF-α pathway.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">05</style></accession-num><section><style face="normal" font="default" size="100%">278</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Varidianto Yudo&lt;sup&gt;1&lt;/sup&gt;, Widjiati&lt;sup&gt;2&lt;/sup&gt;, Harianto Notopuro&lt;sup&gt;2&lt;/sup&gt;, Yulianto Listiawan&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;2&lt;/sup&gt;, Purwo Sri Rejeki&lt;sup&gt;2&lt;/sup&gt;, Prawesty Diah Utami&lt;sup&gt;3&lt;/sup&gt;, Aryati&lt;sup&gt;2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Faculty, Hang Tuah University, Surabaya, Indonesia - Affiliated Doctoral Program of Medical Science, Medical Faculty, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Doctoral Program, Medical Faculty, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medical Faculty, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dody Taruna</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author><author><style face="normal" font="default" size="100%">Harianto Notopuro</style></author><author><style face="normal" font="default" size="100%">Widjiati</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Lilik Herawati</style></author><author><style face="normal" font="default" size="100%">Reny I'tishom</style></author><author><style face="normal" font="default" size="100%">Aryati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of High Intensity Swimming on Heat Shock Protein 70, Superoxide Dismutase and Malondialdehyde of Rattus norvegicus Male Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HSP-70</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA.</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD</style></keyword><keyword><style  face="normal" font="default" size="100%">Strenuous physical activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">524-530</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This study aims to analyze relationship between physical activity with high intensity swimming by proving the difference in the mean levels of HSP-70, SOD levels and MDA levels in male white rats (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who perform vigorous-intensity physical activity compared to male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity.&lt;strong&gt; Method&lt;/strong&gt;: This research is a laboratory experimental research. This research is a True Experimental Research type that uses a Post Test Only Control Group Design research design. The experimental unit consisted of 28 white rats (&lt;em&gt;Rattus norvegicus&lt;/em&gt;). The study was started by dividing the rats into 2 groups. Group 0 who did not receive heavy physical activity treatment and group 1 who received heavy intensity physical activity treatment 3 times a week for 4 weeks. &lt;strong&gt;Results: &lt;/strong&gt;The results of the Shapiro-Wilk test showed that the HSP-70 data were normally distributed (p&amp;lt;0.05). SOD and MDA data for all groups were normally distributed (p&amp;gt;0.05). The results of the Kruskal Wallis test showed that there was a significant difference in HSP-70 between groups (p &amp;gt; 0.05), the results of the Mann Whitney test showed that the HSP-70 of the K0 group was significantly different from the K1 group. The results of the analysis of variance with Brown-Forsythe showed that there was a significant difference in SOD between groups (p &amp;lt; 0.05). The results of the Games Howell test showed that the SOD of group K0 was significantly different from that of group K1. The results of the analysis of variance showed that there was a significant difference in MDA between groups (p &amp;lt; 0.05). The results of the LSD test showed that the MDA of the K0 group was significantly different from the K1 group. &lt;strong&gt;Conclusion&lt;/strong&gt;: There is a difference in the mean levels of HSP-70 in white male rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) whoperform strenuous physical activity, lower than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity. There is a difference in the mean SOD levels in male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) which perform strenuous physical activity, lower than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not do strenuous physical activity. There is a difference in the mean MDA levels in male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) after doing strenuous physical activity, higher than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">06</style></accession-num><section><style face="normal" font="default" size="100%">524</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dody Taruna&lt;sup&gt;1&lt;/sup&gt;, Bambang Purwanto&lt;sup&gt;2&lt;/sup&gt;, Harianto Notopuro&lt;sup&gt;2&lt;/sup&gt;, Widjiati&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;2&lt;/sup&gt;, Lilik Herawati&lt;sup&gt;2&lt;/sup&gt;, Reny I'tishom&lt;sup&gt;2&lt;/sup&gt;, Aryati&lt;sup&gt;2,* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Affiliated Doctoral Program of Medical Science, Medical Faculty, Airlangga University, Surabaya, Indonesia. Medical Faculty, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Doctoral Program, Medical Faculty, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">M. Fathi Ilmawan</style></author><author><style face="normal" font="default" size="100%">Soetjipto</style></author><author><style face="normal" font="default" size="100%">M. Guritno Suryokusumo</style></author><author><style face="normal" font="default" size="100%">M. Miftahussurur</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Hyperbaric Oxygen Therapy on the Expression of FGF, MMP-9 and Occludin in the Repair of Gastric Mucosal Erosions</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">FGF</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastric mucosal erosions</style></keyword><keyword><style  face="normal" font="default" size="100%">HBOT</style></keyword><keyword><style  face="normal" font="default" size="100%">MMP-9</style></keyword><keyword><style  face="normal" font="default" size="100%">Occludin.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">660-671</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study was conducted to evaluate the immunohistochemical (IHC) expression of fibroblast growth factor (FGF), matrix metalloproteinase-9 (MMP-9) and occludin in the repair of gastric mucosal erosions in Wistar rats was induced by administration of aspirin, one of the non-steroidal anti-inflammatory drugs (NSAIDs). These expressions are associated with changes in histopathological features. This experimental research used a posttest only control group design. The research sample was 28 male Wistar rats that met the inclusion criteria, but not met the exclusion criteria. The samples were randomly allocated into four groups. Group 1 as negative control and group 2 as positive control. Group 3 as treatment 1, which was given HBOT (hyperbaric oxygen therapy) 2.4 ATA for 3 x 30 minutes/day (air break 5 minutes) for 5 days, after aspirin induction at 30 mg/kgBW/day for 10 days. Group 4 as treatment 2, which was given HBOT 2.4 ATA for 3 x 30 minutes/day (air break 5 minutes) for 10 days, after aspirin induction at 30 mg/kgBW/day for 10 days. Each group was evaluated the immunohistochemical (IHC) expression of FGF, MMP-9 and occludin, using the Remmele scale index, immune reactive score (IRS). The expressions were correlated with histopathological changes, using the HAI (Histology Activity Index) method. The results show that the HBOT 2.4 ATA for 3 x 30 minutes/day (air break 5 minutes) for 5 days and for 10 days, it can improve FGF (p=0.016) and occludin (p=0.021) expression significantly. The HBOT can also reduce inflammation (p=0.005), epithelial defects (p&amp;lt;0.001) and MMP-9 expression (0.042). There is a significant difference in occludin expression (p=0.034) between 5-day HBOT and 10-day HBOT. However, there was no significant difference between the 5-day HBOT and the 10-day HBOT for reduce inflammation (p=0.845), epithelial defects (p=0.469), FGF expression (0.054) and MMP-9 expression (0.470). The provision of HBOT at 2.4 ATA significantly improved gastric mucosal erosion in NSAID-induced gastric mucosal erosion Wistar rats model, by decreasing MMP-9 expression, as well as increasing FGF and occludin expression. There is a significant difference in occludin expression between 5-day HBOT and 10-day HBOT.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">25</style></accession-num><section><style face="normal" font="default" size="100%">660</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;M. Fathi Ilmawan&lt;sup&gt;1,2&lt;/sup&gt;, Soetjipto&lt;sup&gt;3,*&lt;/sup&gt;, M. Guritno Suryokusumo&lt;sup&gt;4&lt;/sup&gt;, M. Miftahussurur&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Universitas Hang Tuah, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universitas Airlangga Hospital, Surabaya; Institute of Tropical Disease, Department of Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Hyperbaric, Universitas Pembangunan Nasional, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Universitas Airlangga Hospital, Surabaya; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prasetyo Sarwono Putro</style></author><author><style face="normal" font="default" size="100%">Dono Indarto</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author><author><style face="normal" font="default" size="100%">Widyastuti Soewondo</style></author><author><style face="normal" font="default" size="100%">Sulistyani Kusumaningrum</style></author><author><style face="normal" font="default" size="100%">Khim Yatul Nguzum</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effects of Leaves Extract of Toddalia aculeata on Body Weight, Body Mass Index, Body Fat Content and Resistive Index in Male Rats with High-Fat Diet</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Body Fat Content</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Mass Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Resistive Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Toddalia Aculeata Extract.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">771-777</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Dictamine&lt;/em&gt; is found in the Toddalia aculeata plant and is able to interact with &lt;em&gt;Flavin- Containing Monooxygenase-3 &lt;/em&gt;(FMO3) in silico, which mediates endogenous atherosclerosis formation. Therefore, this study aimed to investigate the effects of&lt;em&gt; T. aculeata&lt;/em&gt; extract (TAE) administration on Body Weight (BW), Body Mass Index (BMI), Body Fat Content (BFC), and Resistive Index (RI) in rats with a high-fat diet. &lt;strong&gt;Methods: &lt;/strong&gt;Forty male Sprague-Dawley rats were randomly divided into the negative control (NC), positive control (PC) + 2.98 μg/kg BW &lt;em&gt;dictamine&lt;/em&gt; and treatment (TAE1-3) + 200, 400, and 800 mg/ kg BW TAE respectively. All rats were given a high-fat diet (HFD) for 28 days. The data were analyzed statistically using one-way ANOVA, repeated-measured ANOVA, and Friedman’s tests with p&amp;lt;0.05. &lt;strong&gt;Results:&lt;/strong&gt; The average of rats’ BW in TAE2 (270±13.78 g) and TAE3 (276.62±40.31 g) was lower than that of the NC (304.12± 4.16 g) but only the TAE2 group was significantly different (p=0.032). Rats in the TAE 1-3 groups had the average BMI (26.03±5.61; 21.84±0.81; 20.78±2.17 g/cm&lt;sup&gt;3&lt;/sup&gt;) significantly lower than the NC (29.61±2.28 g/cm&lt;sup&gt;3&lt;/sup&gt;) and the PC (28.67±1.68 g/cm&lt;sup&gt;3&lt;/sup&gt;) for TAE2 and 3. The same pattern was also observed in BFC. All treatment groups had significantly lower RI compared to the NC group (0.62±0.07 cm).&lt;strong&gt; Conclusion&lt;/strong&gt;: Administration of 400 and 800 mg/kg BW TAE for 28 days decreases BW, BMI, BFC, and RI in rats with a high-fat diet. &lt;em&gt;Dictamine&lt;/em&gt; in the ethanol extract of &lt;em&gt;T. aculeata&lt;/em&gt; leaves might contribute to the reduction of RI in rats with a high-fat diet.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">771</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prasetyo Sarwono Putro&lt;sup&gt;1,2&lt;/sup&gt;, Dono Indarto&lt;sup&gt;1,3,4,*&lt;/sup&gt;, Bambang Purwanto&lt;sup&gt;1,5&lt;/sup&gt;, Widyastuti Soewondo&lt;sup&gt;2&lt;/sup&gt;, Sulistyani Kusumaningrum&lt;sup&gt;1,2&lt;/sup&gt;, Khim Yatul Nguzum&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctorate Program of Medical Sciences, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Radiology, Dr. Moewardi General Hospital/Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Biomedical Laboratory, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Audylia Hartono</style></author><author><style face="normal" font="default" size="100%">Mahrus A. Rahman</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Pomegranate Extract Supplementation (Punica granatum L.) on Clinical Manifestations of Pulmonary Arterial Hypertension in Children with Acyanotic Congenital Heart Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Heart disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Pomegranate</style></keyword><keyword><style  face="normal" font="default" size="100%">Pulmonary hypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Sildenafil.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">1061-1066</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pulmonary arterial hypertension (PAH) in congenital heart disease (CHD) mechanism includes vasoconstriction and vascular remodeling. In Indonesia, sildenafil as a vasodilator is the only standard treatment for PAH. Research on pomegranate extract showed its potential as an anti-inflammatory and anti-proliferative agent that could work synergically with sildenafil in reducing pulmonary arterial pressure (PAP) &lt;strong&gt;Objective: &lt;/strong&gt;To investigate the effect of pomegranate supplementation in the clinical manifestation of PAH in children with acyanotic CHD. Methods: This study was a randomized controlled clinical trial that compared the clinical manifestation of PAH in children with acyanotic CHD who received standard therapy for PAH and pomegranate extract supplementation with the placebo group. Observations were carried out over three months, and pre-and post-test evaluations were conducted to assess changes in PAP, functional classification of PAH, body weight, systolic blood pressure, heart rate, respiratory rate, and oxygen saturation in both groups. Statistical analysis was undertaken using the Wilcoxon, Mann-Whitney, and Spearman correlation tests.&lt;strong&gt; Results:&lt;/strong&gt; There was no significant difference in PAP reduction between the pomegranate and placebo groups (&lt;em&gt;p &lt;/em&gt;= .44) and no significant difference in the functional classification of PAH in the placebo and pomegranate groups (&lt;em&gt;p&lt;/em&gt; = .55). There was a considerable reduction in the respiratory rate in the pomegranate group (&lt;em&gt;p&lt;/em&gt; = .017). Respiratory rate was positively correlated with the functional classification of PAH &lt;em&gt;(p&lt;/em&gt; = .011).&lt;strong&gt; Conclusion:&lt;/strong&gt; There was a significant reduction in the respiratory rate in the pomegranate group that correlated with the functional classification of PAH.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">1061</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Audylia Hartono&lt;sup&gt;1&lt;/sup&gt;, Mahrus A. Rahman&lt;sup&gt;1,*&lt;/sup&gt;, Budi Utomo&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Francisco Mercedes Infantes Gomez</style></author><author><style face="normal" font="default" size="100%">Yolanda Elizabeth Rodríguez de Guzmán</style></author><author><style face="normal" font="default" size="100%">Taniht Lisseth Cubas Romero</style></author><author><style face="normal" font="default" size="100%">Natalia Mavila Guzmán Rodríguez</style></author><author><style face="normal" font="default" size="100%">Olga Gessy Rodríguez Aguilar</style></author><author><style face="normal" font="default" size="100%">Ana María Honores Alvarado</style></author><author><style face="normal" font="default" size="100%">Elsa Rocío Vargas Díaz</style></author><author><style face="normal" font="default" size="100%">Lesly Alexandra Cabrera Cabrera</style></author><author><style face="normal" font="default" size="100%">Klersy Almendra Truyenque Román</style></author><author><style face="normal" font="default" size="100%">Edwar Guido Briceño Esquivel</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Satureja brevicalyx essential oil inhalation on coping premenstrual syndrome</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Premenstrual syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Satureja brevicalyx</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">728-735</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The aim of this research was to evaluate the effects of&lt;em&gt; Satureja brevicalyx&lt;/em&gt; essential oil inhalation on premenstrual syndrome.&lt;strong&gt; Methods:&lt;/strong&gt; The oils were extracted by hydro-distillation using a modified Clevenger-type apparatus and chemical composition was performed by Gas chromatography-mass spectrometry (GC–MS). Furthermore, a quasi-experimental study was conducted, where 61 participants were divided in two groups, comprising an experimental with essential oils and a control group with no treatment. Main psychological symptoms were assessed with the used of Zung Self-Rating Anxiety Scale (SAS) and Zung Self-Rating Depression Scale (SDS) as well as total score of premenstrual syndrome was evaluated with Premenstrual Syndrome Scale (PMSS).&lt;strong&gt; Results:&lt;/strong&gt; chemical analysis showed that linalool (17.6%) was the main component. All variables showed a decrease in posttest study phase in comparison with pretest in experimental group (p&amp;lt;0.05). A large size effect was observed for anxiety (d = 1.25; Δ = 1.35). Besides, moderate changes were found for depression (d = 0.79; Δ= 0.81) and premenstrual syndrome total score (d = 0.62; Δ = 0.56)&lt;strong&gt;. Conclusion: &lt;/strong&gt;The essential oil of&lt;em&gt; Satureja brevicalyx &lt;/em&gt;exerts a potencial use, especially for the treatment of psychological symptoms of premenstrual syndrome.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">728</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado-García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto-Vásquez&lt;sup&gt;2&lt;/sup&gt;, Francisco Mercedes Infantes Gomez&lt;sup&gt;1&lt;/sup&gt;, Yolanda Elizabeth Rodríguez de Guzmán&lt;sup&gt;3&lt;/sup&gt;, Taniht Lisseth Cubas Romero&lt;sup&gt;4&lt;/sup&gt;, Natalia Mavila Guzmán Rodríguez&lt;sup&gt;5&lt;/sup&gt;, Olga Gessy Rodríguez Aguilar&lt;sup&gt;6&lt;/sup&gt;, Ana María Honores Alvarado&lt;sup&gt;6&lt;/sup&gt;, Elsa Rocío Vargas Díaz&lt;sup&gt;6&lt;/sup&gt;, Lesly Alexandra Cabrera Cabrera&lt;sup&gt;1&lt;/sup&gt;, Klersy Almendra Truyenque Román&lt;sup&gt;1&lt;/sup&gt;, Edwar Guido Briceño Esquivel&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Medicina. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Enfermería. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Autónoma del Perú, Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Escuela de Psicología. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Escuela de Enfermería. Universidad Privada Antenor Orrego, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prastiya Indra Gunawan</style></author><author><style face="normal" font="default" size="100%">Darto Saharso</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy and Tolerability of Intravenous Paracetamol Compared to Oral Paracetamol for the Treatment of Childhood Fever</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Accessible</style></keyword><keyword><style  face="normal" font="default" size="100%">Efficacy</style></keyword><keyword><style  face="normal" font="default" size="100%">Fever</style></keyword><keyword><style  face="normal" font="default" size="100%">Intravenous paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Tolerability</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">537-541</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Paracetamol is widely used as antipiretic in children and has complete rute. The use of enteral rute is limited because of high variability of bioavailability. Intravenous paracetamol commonly used as accessible analgetic in adult. There are limited data about efficacy and tolerability intravenous paracetamol compares to oral paracetamol as antipiretic in children. The aim of the study is to analyse efficacy and tolerability intravenous paracetamol compared to oral paracetamol for treating fever in children. &lt;strong&gt;Methods:&lt;/strong&gt; A randomized, controlled, and open labelled clinical trial was conducted at pediatric ward Soetomo hospital Surabaya. Eligible patients received either intravenous paracetamol or oral paracetamol 10 mg/kgBW and were examined for temperature at 15, 30, 45, 60, 120, 180 and 240 minutes. Tolerability evaluations included adverse event (AE), physical exam and laboratory assessments. &lt;strong&gt;Results:&lt;/strong&gt; Of 104 patients, 52 received intravenous paracetamol intravena and 52 received oral paracetamol. Mean temperature intravenous group were lower than oral groups, with higher degree of decrease. The difference were achieved at 30, 45, and 60 minutes with p=0.005, 0.002, and 0.006 respectively. Maximum decrease from baseline were achieved at 120-minute for intravenous grup and 180-minute for oral groups. Normal temperature achievement were higher in intravenous group than oral. The adverse event were comparable between the intravenous and oral groups. &lt;strong&gt;Conclusion:&lt;/strong&gt; Intravenous paracetamol is more effective and as safe as oral paracetamol in reducing fever in children.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">537</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prastiya Indra Gunawan*, Darto Saharso&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Pediatric Neurology Division, Department of Child Health, Faculty of Medicine Universitas Airlangga / Dr Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rungtiwa Kanthain</style></author><author><style face="normal" font="default" size="100%">Jirakrit Leelarungrayub</style></author><author><style face="normal" font="default" size="100%">Surinporn Likhitsathian</style></author><author><style face="normal" font="default" size="100%">Surapol Natakankitkul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy of Combined Relaxed Deep-Breathing with Chest Mobilization Exercise and Vernonia cinerea-Hard Candy on Smoking Cessation and Oxidative Stress in Active Teenage Smokers</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">7-day point prevalence abstinence rate</style></keyword><keyword><style  face="normal" font="default" size="100%">Chest mobilization exercise</style></keyword><keyword><style  face="normal" font="default" size="100%">Continuous abstinence rate</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Relaxation deep-breathing</style></keyword><keyword><style  face="normal" font="default" size="100%">Smoking cessation</style></keyword><keyword><style  face="normal" font="default" size="100%">Vernonia cinerea-hard candy.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">720-727</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Smoking cessation is very important worldwide. Chronic smoking can induce oxidative stress and inflammatory status and induce dangerous diseases such as hypertension and lung cancer. Standardized counseling is an important process in a routine program for smoking cessation. Withdrawal symptoms from smoking cessation are a significant barrier to a successful result, and they can be relieved by relaxed deep-breathing exercise. At present, the Thai herb, &lt;em&gt;Vernonia cinerea &lt;/em&gt;(VC), has been claimed to reduce cigarette smoking because of its antioxidant compounds and nicotine that are modified and used as lozenges, gum, and hard candy. However, its efficacy in smoking cessation has not been confirmed. Furthermore, the efficacy of relaxed deep-breathing (rDB) during the chest mobilization exercise (CME) with VC hard candy on smoking cessation and oxidative stress is unclear. Objective: This study aimed to evaluate the combined effects of rDB/CME and VC-hard candy on smoking cessation and oxidative stress status in active teenage smokers. &lt;strong&gt;Methods&lt;/strong&gt;: Hard candy with honey and VC powder from whole mixed parts of the stem, flowers and leaves was developed industrially under the spray dry technique. Thirty active smokers were randomized into three groups; product group (rDB/CME+ product) (aged 25.0 ± 3.0 years, n = 10), placebo group (rDB/CME + placebo) (aged 26.9 ± 3.7 years, n = 10), and a control group with no product or placebo administered (aged 25.6 ± 2.7 years, n=10). All of the groups received consultation on specific smoking cessation and two weeks of strict observation, which was followed up for 8 weeks. The 7-day point prevalence abstinence rates (7-day PAR) and continuous abstinence rate (CAR) were reported at week 2, 4, 6 and 8. In addition, the oxidative stress status with lipid peroxide and glutathione (GSH) in blood was evaluated before the program and after 2 weeks. &lt;strong&gt;Results: &lt;/strong&gt;The results of 7-day PARs in the control group showed no statistical changes at week 2 (0%), 4 (10%), 6 (20%) and 8 (20%), which was the same in the rDB/CME + placebo group (10%, 20%, 30% and 40%, respectively). Whereas, a significant difference was presented in the rDB/CME+ product group (20%, 60%, 80% and 90% respectively). When comparing between the groups, 7-day PARs at week 2 was not statistically different, but it was in the follow-up period at week 4, 6 and 8. There was no statistical difference at week 4 between the three groups, but there was between the rDB/CME+ product, control and rDB/CME+ placebo groups at week 6 and 8. The results of CAR showed no statistical difference between the control and rDB/CWE+ placebo group in any of the periods. Whereas the rDB/CWE+ product group showed a significant difference after week 4. The CAR was statistically different between the groups after week 6 and 8. At week 6, the CAR of the rDB/CWE+ product group was different to the control group. There was no difference between the control and rDB/CWE+ placebo groups, or between the rDB/CWE+ product and placebo groups. At week 8, the CAR of the rDB/CWE+ product group was different from that of the control, but not from the rDB/CWE+ placebo group. Finally, the GSH level increased significantly in the rDB/CWE + product group when compared to the rDB/CWE+placebo group. Moreover, malondialdehyde (MDA) levels decreased significantly in both the placebo and product groups. In addition, MDA levels showed a significant difference between baseline and after 2 weeks in the rDB/CWE + placebo and product groups&lt;strong&gt;. Conclusion:&lt;/strong&gt; Integrating relaxed-deep breathing with chest mobilization exercise and VC hard candy for 2 weeks can help smoking cessation during consultation, and possibly reduce oxidative stress status among active teenage smokers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">720</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rungtiwa Kanthain&lt;sup&gt;1&lt;/sup&gt;, Jirakrit Leelarungrayub&lt;sup&gt;2,*&lt;/sup&gt;, Surinporn Likhitsathian&lt;sup&gt;3&lt;/sup&gt;, Surapol Natakankitkul&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacology, Chiang Mai University, Chiang Mai 50200, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Iwan Sahrial Hamid</style></author><author><style face="normal" font="default" size="100%">Juni Ekowati</style></author><author><style face="normal" font="default" size="100%">Rondius Solfaine</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Muhammad Thohawi Elziyad Purnama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy of Probiotic on Duodenal TNF-α Expression and the Histological Findings in the Liver and Lung in Animal Model Canine Coronavirus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biodiversity</style></keyword><keyword><style  face="normal" font="default" size="100%">Canine coronavirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Lung</style></keyword><keyword><style  face="normal" font="default" size="100%">Probiotic</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">591-597</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Currently, Canine coronavirus (CCoV) is an enteric pathogen of the Alphacoronavirus-1 species that causes mild to severe diarrhea in puppies. The pathogenesis of this infection will cause severe lymphopenia and lead to death in puppies. This study aimed to determine the administration of probiotics on TNF-α expression, histological findings of the liver and lung in mice infected with CCoV. A total of 28 mice were randomly assigned into seven treatment groups, i.e. (C-) placebo; (C+) active CCoV vaccine induction; (T1) CCov + Isopronosin; (T2) CCoV + Lactobacillus acidophilus probiotic; (T3) CCoV + Lactobacillus Acidophylus and Bifidobacterium probiotics; (T4) CCoV + colustrum fermentation probiotic; (T5) CCoV + ginger, turmeric and ginger probiotics. Thereafter, the expression of TNF-α in the duodenum was stained using immunohistochemistry, liver and lung were stained using hematoxylin eosin. The data were analyzed using the ANOVA test followed by the Tukey test with a significance level (p&amp;lt;0.05). TNF-α expression on T4 and T5 decreased significantly (p&amp;lt;0.05) compared to C+, T1, T2 and T3. Histologic findings of the liver in the C- and T4 groups showed normal features in the central vein. On the other hand, glycogen accumulation was found in hepatocyte cells, hemorrhage with sinusoid dilation, lymphocyte infiltration in centro lobular area in group C+. Lung histology showed normal features of sinusoids and alveolar septa in groups C- and T4. Meanwhile, intra-alveolar hemorrhage was found with neutrophil cell infiltration and fibrin plasma accumulation in group C+. In conclusion, colostrum fermentation probiotics can reduce TNF-α expression in the duodenum and improve the liver and lung physiology in mice infected with CCoV.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">16</style></accession-num><section><style face="normal" font="default" size="100%">591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Iwan Sahrial Hamid&lt;sup&gt;1,*&lt;/sup&gt;, Juni Ekowati&lt;sup&gt;2&lt;/sup&gt;, Rondius Solfaine&lt;sup&gt;3&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;4&lt;/sup&gt;, Muhammad Thohawi Elziyad Purnama&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pathology, Faculty of Veterinary Medicine, Universitas Wijaya Kusuma Surabaya, Surabaya, 60225, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Animal Science, College of Natural Resources, Royal University of Bhutan, Lobesa, Punakha, 13001, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aprilia Romdiyana</style></author><author><style face="normal" font="default" size="100%">R. Mohammad Budiarto</style></author><author><style face="normal" font="default" size="100%">Evelyne Chandra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Erlenmeyer-shaped Heart in a Patient with Giant Left Atrium due to Mixed Mitral Valve Pathology: A Neglected Case in a Rural Area in Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Erlenmeyer-shaped heart</style></keyword><keyword><style  face="normal" font="default" size="100%">Giant left atrium</style></keyword><keyword><style  face="normal" font="default" size="100%">Junctional tachycardia.</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitral regurgitation</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitral stenosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">829-832</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Giant left atrium (GLA) is a rare condition typically found in patients with rheumatic mitral valve disease. On chest radiographs, this condition often mimics another cause of cardiomegaly. A 52-year-old man was admitted to the hospital with complaints of shortness of breath and orthopnea. Mid-diastolic and grade IV pansystolic murmurs could be heard at the apex radiating to the axilla on cardiac auscultation. The electrocardiogram showed a junctional tachycardia rhythm, while the chest radiograph displayed extreme cardiomegaly with Erlenmeyer-shaped heart. Massive pericardial effusion was suspected. Transthoracic echocardiography (TTE) was then performed, revealing GLA with a left atrial volume index (LAVi) of 1101 ml/m2. Meanwhile, transoesophageal echocardiography (TEE) confirmed calcification of P2 and P3 extending to the border of the mitral leaflet up to one third of the chordae tendineae, with moderate mitral stenosis and eccentric mitral regurgitation jet due to prolapse of A2. The patient was treated with optimal medical therapy while awaiting cardiac surgery. GLA is a rare complication of mitral valve disease and an almost forgotten cause of cardiomegaly. Diagnostic imaging procedures with echocardiography are a less invasive and readily available modality to establish the diagnosis of cardiomegaly.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">829</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aprilia Romdiyana*, R. Mohammad Budiarto, Evelyne Chandra&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Cardiology and Vascular Medicine, Airlangga University, Dr Soetomo General Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramadanil Pitopang</style></author><author><style face="normal" font="default" size="100%">Ihwan</style></author><author><style face="normal" font="default" size="100%">Muhammad Sulaiman Zubair</style></author><author><style face="normal" font="default" size="100%">Nurhaeni</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Essential Oils Constituent of Etlingera flexuosa (Zingiberaceae), An Endemic Plant from Central Sulawesi</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Etlingera flexuosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrodistillation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">842-846</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The essential oils from rhizomes, pseudostems, and leaves of &lt;em&gt;Etlingera flexuosa,&lt;/em&gt; an endemic ginger species of Sulawesi, were studied.&lt;strong&gt; Methods&lt;/strong&gt;: The essential oils were extracted using solvent extraction and hydrodistillation methods and analysed by gas chromatography-mass spectrometry (GC-MS). &lt;strong&gt;Results:&lt;/strong&gt; The percentage yield of volatile compounds obtained from solvent extraction method was higher than hydrodistillation. By solvent extraction, sesquiterpenes were found abundantly in rhizomes, pseudostems, and leaves with the percentage of 34.16%, 35.20% and 32.70%, respectively. The rhizome and pseudostems were found to contain spathulanol with the high percentage of 3.91% and 3.46%. Meanwhile, by hydrodistillation, the compounds were dominated by fatty acid compunds with the percentage of 82.26%, 82.79% and 76.1% on rhizome, pseudostems and leaves. Glycerol tricaprylate has the high percentage of 66.76% and 82.12% on rhizome and pseudostems, while in leaves, fatty acids 1,2,3-propanetriyl ester-decanoic acid was the highest with the percentage of 61.81%. Sesquiterpenes was the second with the percentage of 10.36%, 11.15%, and 11.61% in rhizomes, pseudostems, and leaves, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The most essential oils of &lt;em&gt;E. flexuosa&lt;/em&gt; was obtained from the solvent extraction method.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">842</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ramadanil Pitopang&lt;sup&gt;1&lt;/sup&gt;, Ihwan&lt;sup&gt;2&lt;/sup&gt;, Muhammad Sulaiman Zubair&lt;sup&gt;2&lt;/sup&gt;, Nurhaeni&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Mathemathics &amp;amp; Natural Sciences, Tadulako University, Palu, Central Sulawesi, 94118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Mathemathics &amp;amp; Natural Sciences, Tadulako University, Palu, Central Sulawesi, 94118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry, Faculty of Mathemathics &amp;amp; Natural Sciences, Tadulako University, Palu, Central Sulawesi, 94118, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Candra Irawan</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Ethanolic Extract of Rhinachantus nasutus (L.) Kurz Flower has Antioxidant, Anti-Gout, and Antibacterial Potential</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP</style></keyword><keyword><style  face="normal" font="default" size="100%">RnLK</style></keyword><keyword><style  face="normal" font="default" size="100%">TBHBA</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">867-872</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The goal of this research was to explore the potential of &lt;em&gt;Rhinachantus nasutus&lt;/em&gt; (L.) Kurz (RnLK) flower extract as an antioxidant utilizing the ferric reducing antioxidant power (FRAP) method; the possibility that it might be used as a treatment for gout by employing the 2,4,6-tribromo-3-hydroxybenzoic acid (TBHBA) technique, as well as the possibility that it could be used as an antibacterial agent against&lt;em&gt; E. coli &lt;/em&gt;and B. subtilis. Results: The IC&lt;sub&gt;50 &lt;/sub&gt;value for the extract's ability to serve as an antioxidant is 8.62±0.006 mg/L, indicating that it is quite effective. In addition, the extract of ethanol possesses highly potent anti-gout properties, being capable of bringing about a 81.95±0.1% reduction in uric acid levels. In spite of this, the antibacterial properties of &lt;em&gt;E. coli &lt;/em&gt;as well as &lt;em&gt;B. subtilis&lt;/em&gt; bacteria were not particularly robust. Conclusion: The RnLK flower has the potential to produce alternative chemicals with the ability to reduce blood uric acid levels, but according to the results of the test, the antibacterial activity has little impact on &lt;em&gt;E. coli&lt;/em&gt; and B. subtilis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">867</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Candra Irawan&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,*&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;3&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Food Nanotechnology, Politeknik AKA Bogor, Bogor, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Science, Serpong, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Miloud Chakit</style></author><author><style face="normal" font="default" size="100%">Aboubaker El Hessni</style></author><author><style face="normal" font="default" size="100%">Abdelhalim Mesfioui</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Study of Plants Used for the Treatment of Urolithiasis in Morocco </style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Morocco.</style></keyword><keyword><style  face="normal" font="default" size="100%">Questionnaire</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Urolithiasis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">542-547</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Urolithiasis (UL) is a frequent pathology which affects between 5 and 20% of the population according to the countries and areas. The aim of this study was to determine the medicinal plants used traditionally by patients with UL in the Kenitra and Sidi Kacem cities (Morocco). From January 2012 to February 2015, 50 herbalists and 166 patients with urolithiasis who live in the area under study were interviewed by using structured questionnaire. The following data were recorded: name of the patients or herbalists with their age, sex name of the plant (s) (vernacular name), parts used mode of preparation and administration. A total of 42 plant species belonging to 24 families, mostly from the Apiaceae (16.66%) &lt;em&gt;Lamiaceae&lt;/em&gt; (11.9%) were used to treat the UL in the area. All the plants were prepared by decoction which are taken orally for a period of one week. &lt;em&gt;Herniaria hirsuta &lt;/em&gt;(Hh) and &lt;em&gt;Ziziphus lotus &lt;/em&gt;(Zl) were repeatedly mentioned by the patients and herbalists as most used for the management of UL in this area. It’s concluded that the traditional remedies are the first line to treat the UL in this area. Hh and Zl were the most commonly used plants in this treatment which a study of antiurolithiatic characteristics seem to be necessary to evaluate its use in therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">542</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Miloud Chakit*, Aboubaker El Hessni, Abdelhalim Mesfioui&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">SYLVIA RIZKY PRIMA</style></author><author><style face="normal" font="default" size="100%">ELFAHMI</style></author><author><style face="normal" font="default" size="100%">ELIN JULIANTI</style></author><author><style face="normal" font="default" size="100%">Irda Fidrianny</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antibacterial and Antioxidant Activity of Endophytic Fungi Isolated from CAPSICUM ANNUUM L. and ALLIUM CEPA L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Chaetomium globosum</style></keyword><keyword><style  face="normal" font="default" size="100%">Endophytic fungus</style></keyword><keyword><style  face="normal" font="default" size="100%">Onion</style></keyword><keyword><style  face="normal" font="default" size="100%">Red chili</style></keyword><keyword><style  face="normal" font="default" size="100%">Schizophyllum commune</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">329-334</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aims of this study were to identify the endophytic fungi from &lt;em&gt;Capsicum annuum &lt;/em&gt;L. and &lt;em&gt;Allium cepa &lt;/em&gt;L., to determine antioxidant and antimicrobial activity of ethyl acetate extract of endophytic fungi isolated from&lt;em&gt; C. annuum&lt;/em&gt; and &lt;em&gt;A. cepa&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Endophytic fungi was isolated with potato dextrose agar (PDA) from fruits of &lt;em&gt;C. annuumand &lt;/em&gt;bulbs of&lt;em&gt; A. cepa.&lt;/em&gt; Isolate of endophytic fungi was molecular identified to know the species or genus. Cultivation was carried out on rice media, 4 weeks on room temperature and the extraction by maceration using ethyl acetate. Antioxidant activity were tested by DPPH method. While antibacterial activity was tested by disk diffusion methods and microdilution methods.&lt;strong&gt; Results: &lt;/strong&gt;Five isolates of endophytic fungi from red and green fruits of &lt;em&gt;C. annuum&lt;/em&gt; and bulb of &lt;em&gt;A. cepa &lt;/em&gt;have been isolated and the species or the genus have been confirmed. KCM 1 and KCM 2 isolates endophytic fungi from the red fruits of&lt;em&gt; C. annuum &lt;/em&gt;were confirmed as &lt;em&gt;Diaporthe sp&lt;/em&gt; and Chaetomium globosum. The KCH 1 isolate from green fruits of the &lt;em&gt;C. annuum&lt;/em&gt; was confirmed as &lt;em&gt;Trametes hirsuta. &lt;/em&gt;The KBM 1 and KBM 2 isolates from &lt;em&gt;A. cepa&lt;/em&gt; were confirmed as &lt;em&gt;Schizophyllum&lt;/em&gt; commune and &lt;em&gt;Phlebia sp. &lt;/em&gt;The highest antioxidant and antibacterial activity was exposed by ethyl acetate extract of S. commune. &lt;strong&gt;Conclusion: &lt;/strong&gt;Five isolates endophytic fungi from &lt;em&gt;C. annuum&lt;/em&gt; and&lt;em&gt; A. cepa w&lt;/em&gt;ere &lt;em&gt;Diaporthe sp, C. globosum, T. hirsuta, S. commune&lt;/em&gt; and &lt;em&gt;Phlebia sp&lt;/em&gt;. Ethyl acetate extract of &lt;em&gt;S.commune &lt;/em&gt;gave highest antioxidant and antibacterial activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">329</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;SYLVIA RIZKY PRIMA&lt;sup&gt;1,2*&lt;/sup&gt;, ELFAHMI&lt;sup&gt;1&lt;/sup&gt;, ELIN JULIANTI&lt;sup&gt;1&lt;/sup&gt;, IRDA FIDRIANNY&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy – Bandung of Technology, Bandung, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, University August 17, 1945 Jakarta, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thi-Lien Nguyen</style></author><author><style face="normal" font="default" size="100%">Huong Ha Thi Thanh</style></author><author><style face="normal" font="default" size="100%">Kiet Ngo Tuan</style></author><author><style face="normal" font="default" size="100%">Doan Cao Son</style></author><author><style face="normal" font="default" size="100%">Thao Le Quang</style></author><author><style face="normal" font="default" size="100%">Hang Nguyen Thi</style></author><author><style face="normal" font="default" size="100%">Tien Vuong Duy</style></author><author><style face="normal" font="default" size="100%">Quyen Doan Thi Tam</style></author><author><style face="normal" font="default" size="100%">Huan Le Quang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antiviral Effects and Toxicity of Herbal Medicine Vipdervir Capsules</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">H5N1</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">681-689</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Antiviral vaccine is not effective, synthetic antiviral drugs are highly toxic, leading to increased interest in herbal medicines as promising antiviral drugs. Recently, Vipdervir has been developed from medicinal herbs with the aim to support and treat diseases caused by viruses such as H5N1 and SARSCoV- 2. In the present study, we assessed Vipdervir's antiviral activity against H5N1 and SARS-CoV-2. In addition, we also evaluated the acute toxicity and repeated dose toxicity of Vipdervir in mice and rabbits, respectively. &lt;strong&gt;Methods&lt;/strong&gt;: H5N1 inhibitory effect of Vipdervir was assessed using hemagglutination inhibition assay. Vipdervir's SARS-CoV-2 inhibitory effect was evaluated by Plaque Reduction Neutralization assay. Acute and repeated dose oral toxicities of Vipdervir were determined according to OECD 423 and OECD 407 guidelines, respectively. &lt;strong&gt;Results:&lt;/strong&gt; Data show that Vipdervir is effective against both H5N1 and SARSCoV- 2. At concentrations of 3 mg/mL and 5 mg/mL Vipdervir completely inhibits H5N1. At a concentration of 50 μg/mL Vipdervir showed an inhibitory effect on SARS-CoV-2. Acute toxicity data revealed that the LD50 of Vipdervir is greater than 35200 mg/kg, b.wt. in mice. Repeated toxicity data indicated that Vipdervir did not induce significant differences in body weight gain, hematology and clinical biochemistry in compared to the control group. The No Observed Adverse Effect Level of Vipdervir is greater than 613.8 mg/kg b.wt./day in rabbits. No delayed toxicity effects of Vipdervir were observed. &lt;strong&gt;Conclusion&lt;/strong&gt;: Vipdervir capsules were found to be antiviral effective and relatively safe in the tested doses and experimental conditions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">27</style></accession-num><section><style face="normal" font="default" size="100%">681</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Thi-Lien Nguyen&lt;sup&gt;1,*&lt;/sup&gt;, Huong Ha Thi Thanh&lt;sup&gt;2&lt;/sup&gt;, Kiet Ngo Tuan&lt;sup&gt;3&lt;/sup&gt;, Doan Cao Son&lt;sup&gt;1&lt;/sup&gt;, Thao Le Quang&lt;sup&gt;1&lt;/sup&gt;, Hang Nguyen Thi&lt;sup&gt;1&lt;/sup&gt;, Tien Vuong Duy&lt;sup&gt;1&lt;/sup&gt;, Quyen Doan Thi Tam&lt;sup&gt;4&lt;/sup&gt;, Huan Le Quang&lt;sup&gt;5,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;National Institute of Drug Quality Control, 48-Hai Ba Trung st., Hoan Kiem dist., Ha Noi city, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet st., Cau Giay dist., Ha Noi city, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;University of Science and Technology of Hanoi, 18-Hoang Quoc Viet st., Cau Giay dist., Ha Noi city, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;High School for Gifted Students, Hanoi University of Science, 182- Luong The Vinh St., Thanh Xuan dist., Ha Noi city, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Institute of Biotechnology, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet st., Cau Giay dist., Ha Noi city, VIETNAM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maulana Yusuf Alkandahri</style></author><author><style face="normal" font="default" size="100%">Afiat Berbudi</style></author><author><style face="normal" font="default" size="100%">Anas Subarnas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Experimental Cerebral Malaria of Curcumin and Kaempferol in Plasmodium berghei ANKA-Infected Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Blood-brain barrier.</style></keyword><keyword><style  face="normal" font="default" size="100%">Cerebral malaria</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaempferol</style></keyword><keyword><style  face="normal" font="default" size="100%">Kurkumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasmodium berghei Anka</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">905-911</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cerebral malaria (CM) is one of the most severe complications of &lt;em&gt;Plasmodium falciparum&lt;/em&gt; infection and the leading cause of death from malaria in endemic areas. Natural products with antioxidant and anti-inflammatory activities have become valuable alternative therapeutic options in CM treatment. Therefore, this study aimed to investigate the neuroprotective effects of curcumin and kaempferol in experimental cerebral malaria (ECM) in mice infected with &lt;em&gt;Plasmodium berghei &lt;/em&gt;ANKA (PbA). &lt;strong&gt;Methods:&lt;/strong&gt; After PbA infection, mice were divided into 9 groups, namely Group I (negative control (NC)) with 0.5% HPMC, Group II received chloroquine 20 mg/kg, Group III (normal) with aquadest, Groups IV, V, and VI received curcumin at doses of 20, 40, and 80 mg/kg, respectively, Groups VII, VIII, and IX received kaempferol at doses of 20, 40, and 80 mg/kg, respectively. The antimalarial activity was evaluated using Peter's four-day suppressive test. This was conducted to determine the % parasitemia, survival rate, AST and ALT, blood-brain barrier (BBB) leakage, and neurobehavioral disorders in mice with CM. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that all treatments had significant antimalarial activity, with the % suppression depending on the dose. It also indicates that PbA-infected mice had a survival rate of 11-19 days after infection, which was higher than those in the NC group. This suggested that curcumin and kaempferol have a protective effect on the survival of PbA-infected mice. Furthermore, they significantly reduced the AST and ALT concentrations in the sample compared to the NC group. The same was observed in cerebral vessel extravasation, where the Evans Blue stain assay showed significantly less dye extravasation in the brains of PbA-infected mice treated with curcumin and kaempferol. This indicated better-protected integrity of the BBB. Additionally, the results also demonstrated a decrease in neurological disorders arising during ECM in the group treated with curcumin and kaempferol. &lt;strong&gt;Conclusion&lt;/strong&gt;: Considering these results, it is concluded that treatments with curcumin and kaempferol could improve animal survival, prevent AST and ALT elevations, as well as protect the BBB and neurobehavioral disorders associated with CM in PbA-infected mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">905</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maulana Yusuf Alkandahri&lt;sup&gt;1,2*&lt;/sup&gt;, Afiat Berbudi&lt;sup&gt;3&lt;/sup&gt;, Anas Subarnas&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biomedical Sciences, Parasitology Division, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A EZAOUINE</style></author><author><style face="normal" font="default" size="100%">M R SALAM</style></author><author><style face="normal" font="default" size="100%">Y SBAOUI</style></author><author><style face="normal" font="default" size="100%">B NOUADI</style></author><author><style face="normal" font="default" size="100%">S ZOUHIR</style></author><author><style face="normal" font="default" size="100%">M ELMESSAL</style></author><author><style face="normal" font="default" size="100%">F CHEGDANI</style></author><author><style face="normal" font="default" size="100%">F BENNIS</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extraction, Chemical Composition and Antioxidant Activity of Phenolic Compounds from Moroccan Satureja nepeta L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">182-192</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Satureja&lt;/em&gt; nepeta is an aromatic medicinal plant, widely used by the Moroccan population. The objective of this study is to evaluate the influence of extraction methods on total phenolic compounds (TPC) and total flavonoid compounds (TFC). The phytochemical characteristics are subsequently analyzed to determine the components constitution as well as the evaluation of antioxidant activity. The extraction optimization and the extraction of total polyphenols was carried out using three methods (decoction, infusion and hydroethanolic). The antioxidant capacity was evaluated using the DPPH free radical trapping method, reducing power assay and the ABTS radical reduction test. Polyphenols were identified by the HPLCUV method. The optimal hydro-ethanol extraction conditions defined from the experimental design are: ethanol/water, 60/40 (v/v), 15 hours, 42.5 °C TPC and TFC of the infused extract were the highest. The evaluation of the antioxidant capacity showed that the infused extract had a good antioxidant efficacy. HPLC-UV and GC-MS has been used to identify some phenolic compounds in various extracts. In conclusion, optimizing the extraction of S. nepeta seems to be an efficient and quick method to establish the best extraction conditions. Also, &lt;em&gt;Satureja.&lt;/em&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Moroccan Satureja nepeta, Antioxidant activity, Total polyphenol, Total flavonoids, Total tannins.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">182</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;A EZAOUINE *, M R SALAM,Y SBAOUI, B NOUADI, S ZOUHIR, M ELMESSAL, F CHEGDANI, F BENNIS&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Laboratory of Immunology and Biodiversity, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, Morocco&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Cristel M. Ortiz-Noriega</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">William A. Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Anabel D. González- Siccha</style></author><author><style face="normal" font="default" size="100%">María V. González-Blas</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">Jorge Del Rosario-Chávarri</style></author><author><style face="normal" font="default" size="100%">Patricia Contreras- Vera</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of a Gel Based on Ipomoea batatas (Purple Sweet Potato) on Dermal Wound Healing in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histology</style></keyword><keyword><style  face="normal" font="default" size="100%">Ipomoea batatas</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin.</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1720-1726</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Ipomoea batatas &lt;/em&gt;(L.) Lam. (I. batatas) is a root native from South America that is characterized by its antioxidant, antimicrobial and anti-inflammatory properties. These properties contribute to the wound healing process. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the healing activity of a gel based on&lt;em&gt; I. batatas&lt;/em&gt; on dermal wound healing in mice.&lt;strong&gt; Material and methods: &lt;/strong&gt;An acid ethanolic extract (1.5 N hydrochloric acid: Ethanol 96 ° 15:85, v / v) was prepared with the peels of the roots of &lt;em&gt;I. batatas&lt;/em&gt; &quot;purple sweet potato&quot;, which was incorporated into the formulations 0.5% and 1% gel. Mus musculus Balb / c with induced injury were distributed in four experimental groups: Group I (Control), which did not receive any treatment. Group II (Gel base), Group III (Gel&lt;em&gt; I. batatas&lt;/em&gt; 0.5%) and Group IV (Gel &lt;em&gt;I. batatas&lt;/em&gt; 1%) received the daily administration of topical treatments for 14 days. Wound closure was determined during the experimentation time, then they were euthanized with sodium pentobarbital 60 mg / kg / pc v.ip. to obtain skin samples for histopathological analysis. &lt;strong&gt;Results: &lt;/strong&gt;Group IV shows a higher percentage of wound closure, which is also evidenced in histopathological changes. &lt;strong&gt;Conclusions:&lt;/strong&gt; The 1% gel based on the ethanolic extract of the peels of the roots of &lt;em&gt;Ipomoea batatas &lt;/em&gt;(L.) Lam. they show healing activity in wounds induced in mice, being the most effective treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1720</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1&lt;/sup&gt;,*, Cristel M. Ortiz-Noriega&lt;sup&gt;1&lt;/sup&gt;, Víctor E. Villarreal- La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;2&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero-Espino&lt;sup&gt;3&lt;/sup&gt;, William A. Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, José L. Cruzado- Razco&lt;sup&gt;1&lt;/sup&gt;, Jorge Del Rosario- Chávarri&lt;sup&gt;2&lt;/sup&gt;, Patricia Contreras-Vera&lt;sup&gt;4&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ. 4Hospital Víctor Lazarte Echegaray, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Cristel M. Ortiz-Noriega</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of a Gel Based on Ipomoea batatas (Purple Sweet Potato) on Dermal Wound Healing in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histology</style></keyword><keyword><style  face="normal" font="default" size="100%">Ipomoea batatas</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin.</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1720-1726</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Ipomoea batatas &lt;/em&gt;(L.) Lam. (I. batatas) is a root native from South America that is characterized by its antioxidant, antimicrobial and anti-inflammatory properties. These properties contribute to the wound healing process. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the healing activity of a gel based on&lt;em&gt; I. batatas&lt;/em&gt; on dermal wound healing in mice.&lt;strong&gt; Material and methods: &lt;/strong&gt;An acid ethanolic extract (1.5 N hydrochloric acid: Ethanol 96 ° 15:85, v / v) was prepared with the peels of the roots of &lt;em&gt;I. batatas&lt;/em&gt; &quot;purple sweet potato&quot;, which was incorporated into the formulations 0.5% and 1% gel. Mus musculus Balb / c with induced injury were distributed in four experimental groups: Group I (Control), which did not receive any treatment. Group II (Gel base), Group III (Gel&lt;em&gt; I. batatas&lt;/em&gt; 0.5%) and Group IV (Gel &lt;em&gt;I. batatas&lt;/em&gt; 1%) received the daily administration of topical treatments for 14 days. Wound closure was determined during the experimentation time, then they were euthanized with sodium pentobarbital 60 mg / kg / pc v.ip. to obtain skin samples for histopathological analysis. &lt;strong&gt;Results: &lt;/strong&gt;Group IV shows a higher percentage of wound closure, which is also evidenced in histopathological changes. &lt;strong&gt;Conclusions:&lt;/strong&gt; The 1% gel based on the ethanolic extract of the peels of the roots of &lt;em&gt;Ipomoea batatas &lt;/em&gt;(L.) Lam. they show healing activity in wounds induced in mice, being the most effective treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1720</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1&lt;/sup&gt;,*, Cristel M. Ortiz-Noriega&lt;sup&gt;1&lt;/sup&gt;, Víctor E. Villarreal- La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;2&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero-Espino&lt;sup&gt;3&lt;/sup&gt;, William A. Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, José L. Cruzado- Razco&lt;sup&gt;1&lt;/sup&gt;, Jorge Del Rosario- Chávarri&lt;sup&gt;2&lt;/sup&gt;, Patricia Contreras-Vera&lt;sup&gt;4&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ. 4Hospital Víctor Lazarte Echegaray, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Pholawat Tingpej</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author><author><style face="normal" font="default" size="100%">Thanes Fuangfoo</style></author><author><style face="normal" font="default" size="100%">Jarinyaporn Naowaboot</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Aporosa villosa Stem Ethanolic Extract on Adipogenesis in 3T3-L1 Adipocytes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aporosa villosa; Adipogenesis; Obesity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1422-1427</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: An excessive fat accumulation is related to development of obesity. Obesity is associated with the induction of insulin resistance and diabetes mellitus conditions. &lt;em&gt;Aporosa villosa &lt;/em&gt;is a plant that found in the Northern and Northeastern region of Thailand.&lt;strong&gt; Objective: &lt;/strong&gt;The present study used 3T3-L1 adipocytes for investigating the effect of &lt;em&gt;Aporosa villosa&lt;/em&gt; stem ethanolic extract (AS) on adipogenesis. &lt;strong&gt;Materials and Methods&lt;/strong&gt;: 3T3-L1 adipocytes were used for measuring the cytotoxicity of AS at a concentration range of 3-100 μg/mL. After adipocyte cells treated with AS (3-100 μg/mL) for 8 days, the lipid accumulation was detected by Oil Red O staining and adipogenic gene expression were determined by quantitative real-time PCR. &lt;strong&gt;Results: &lt;/strong&gt;AS extracts (3-100 μg/mL) did not show cytotoxicity on cell proliferation. After 8 days of treating 3T3-L1 adipocytes with AS at doses of 3, 10, 30 and 100 μg/mL, the lipid droplets were reduced as compared to non-treated cells. Furthermore, the adipogenic genes were measured. The regulators of adipogenesis, CCAAT/enhancer-binding protein α (C/EBPα), peroxisome proliferatoractivated receptor γ (PPARγ) and sterol regulatory element binding protein 1c (SREBP1c) were found decreasing in AS extracts. The downstream target genes of these regulators cluster of differentiation (CD) 36, fatty acid synthase (FAS) and lipoprotein lipase (LPL) were also reduced by AS treatments. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings indicate that AS extract has an inhibitory activity on adipogenesis in 3T3-L1 adipocytes via suppressing C/EBPα, PPARγ and SREBP1c.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1422</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Pholawat Tingpej&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;3&lt;/sup&gt;, Thanes Fuangfoo&lt;sup&gt;4 &lt;/sup&gt;&amp;nbsp;Jarinyaporn Naowaboot&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, College of Pharmacy, Rangsit University, Pathum Thani 12120, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author><author><style face="normal" font="default" size="100%">Aulia Jihan Miranda</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Artocarpus altilis (Parkinson) Fosberg Extract Supplementation on Kidney Ischemia-Reperfusion Injury Rat</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute kidney disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Artocarpus altilis (Parkinson) Fosberg</style></keyword><keyword><style  face="normal" font="default" size="100%">Free Radicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Reperfusion injury</style></keyword><keyword><style  face="normal" font="default" size="100%">Sukun</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">150-154</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Acute kidney injury (AKI) is a kidney disease resulting in high morbidity and mortality levels in humans. One of the disorders classified as AKI is ischemia-reperfusion injury (IRI), characterized by two phases. The first phase is Ischemia in the kidneys due to obstruction of the renal arteries or veins, followed by the second phase, which is the occurrence of reperfusion with blood flowing back in the renal arteries veins. The aim of this current research is to analyze the efficacy of Artocarpus altilis on Kidney ischemiareperfusion model rats. &lt;strong&gt;Methods:&lt;/strong&gt; To this end, first, we established Ischaemia-reperfusion kidney injury rat. We then evaluated the Artocarpus altilis extract on IRI model rats. A total of 36 rats have grouped into six groups. Group I is the Sham group, Group II is the negative control group, Group III is the positive control group (vitamin C 100 mg/kg BW), Group IV is Dose I of Artocarpus altilis extract 50 mg/kg BW), Group V is Dose II Artocarpus altilis extract 100 mg/kg BW), Group VI is Dose III Artocarpus altilis extract 200 mg/kg BW). The vitamin C and Artocarpus altilis extract administered 14 days before and after Ischemia-reperfusion treatment. At day 0, Ischemia was made by bilateral renal pedicle clamping method for 30 minutes, sacrificed 14 days after reperfusion. The blood and histology samples were collected on day 0, a day after reperfusion, at 24 hrs after reperfusion, at 48 hrs after reperfusion, and 14 days after treatment. &lt;strong&gt;Results:&lt;/strong&gt; The clamping duration of 30 minutes leads to achieving the most representative clinical IRI conditions. It shows the most significant recovery of injury conditions within the 14-day reperfusion period in IRI animal models, making it ideal for IRI operations for the preliminary test. The administration of 100 mg/kg BW of Artocarpus altilis extract could reduce the malondialdehyde plasma compared with the sham group. The SOD and Catalase activity showed improvement after reperfusion. &lt;strong&gt;Conclusion:&lt;/strong&gt; Artocarpus altilis extracts showed antioxidant activity to prevent the kidney from ischemia-reperfusion injury by modulated SOD and Catalase.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anton Bahtiar&lt;sup&gt;1,&lt;/sup&gt;*, Aulia Jihan Miranda&lt;sup&gt;1&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok 16424, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia. Kampus UI Salemba, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Budi Siswanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Ethanol Extract of Katuk Leaves (Sauropus androgynus) on Red Blood Cell Count (HR), Hemoglobin (Hb), and Hematocrit (Ht) of Rats Exposed to Emission</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Air Pollution</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematology</style></keyword><keyword><style  face="normal" font="default" size="100%">Katuk Leaves</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">860-865</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The World Health Organization (WHO) estimates that 70% of the world's urban population has breathed polluted air from motorcycle emissions. Lead poisoning will have an impact on anemia which is characterized by a decrease in the amount of red blood cell count (RBC), hemoglobin level (Hb), and hematocrit level (Ht). Katuk leaves contain papaverine which can bind to the red blood cell. The purpose of this research is to see the ability of the ethanol extract of katuk leaves (&lt;em&gt;Sauropus androgynus&lt;/em&gt;) to prevent the reduction of RBC, Hb, and Ht. The descriptive, experimental research method that analyzes changes in hematological parameters in experimental rats was conducted 24 days with samples of 30 white rats species of Rattus norvegicus, divided into five groups: control (-), control (+), Treatment 1 (P1, extract 50 mg/kg body weight), Treatment 2 (P2, extract 100 mg/kg body weight), and Treatment 3 (P3, extract 200 mg/kg body weight). All rats used in treatment groups were exposed to motorcycle smoke. The study was carried out for 16 days, and on day-17, all groups were drawn blood through the orbital vein. The results showed the concentration of extract of 200 mg/kg weight has the highest increase in hematological parameters for RBC (8.42 ± 0.67); Hb (14.0 ± 0.48); and Ht (44.6 ± 0.89). Katuk leaf ethanol extract had a significant effect (p &amp;lt;0.05) in increasing RBC, Hb, and Ht. Therefore, the ethanol extract of katuk leaves can be a potential drug candidate for medicine in conditions where lower hematological parameters occur due to exposure to air pollution.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">860</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Budi Siswanto*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Medical Laboratory Technology Department, Health Polytechnic of Banten, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Luqyana Putri</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Ethanol Extract of Moringa Leaf (Moringa oleifera Lam) Against the Activity and Capacity of Phagocytosis of Macrofag Cells and the Percentage of Leukosit Cells of White Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">macrophage cell</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera Lam</style></keyword><keyword><style  face="normal" font="default" size="100%">Phagocytosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus aureus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">706-712</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; This study aims to determine the activity, capacity of macrophage phagocytosis, and percentage of leukocyte cells of male mice treated with the ethanol extract of moringa leaves (&lt;em&gt;Moringa oleifera&lt;/em&gt; Lam).&lt;strong&gt; Methods: &lt;/strong&gt;Twenty male mice were divided into four equal groups. The extract was administered orally for seven days at a dose of 10; 30; 100 mg/kg; and 0.5% CMC Na suspension as a negative control. On the 8&lt;sup&gt;th&lt;/sup&gt; day, the percentage of blood cell leukocytes in mice tail was calculated using a microscope. Suspension of &lt;em&gt;Staphylococcus aureus &lt;/em&gt;was injected intraperitoneally. The peritoneal fluid was taken to figure the activity and capacity of macrophage cell phagocytosis. The activity and capacity of macrophage cells are calculated using a microscope. The data were statistically analyzed by the one-way variance analysis (ANOVA) method and Duncan test.&lt;strong&gt; Results:&lt;/strong&gt; The results showed that giving oral ethanol extract of Moringa leaves on male could increase macrophage activity and capacity, increasing dose, macrophage activity number, and capacity increased. The highest activity and capacity was achieved at a dose of 100 mg/kg. Moringa leaf extract can also increase the percentage of banded neutrophil, lymphocytes, eosinophil cells and decrease the percentage of neutrophil cell segments and monocytes from male white mice. The highest percentage of banded neutrophil, lymphocytes, eosinophils, and reductions in the percentage of neutrophil cell segments, monocytes present at doses of 100 mg/kg. &lt;strong&gt;Conclusion: &lt;/strong&gt;From the result, it can conclude that ethaol extract of Moringa Leaf can increase the activity and capacity of macrophages and percentage of neutrophils.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">706</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Elsa Badriyya, Luqyana Putri, Yufri Aldi &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhamad Iyad bin Ramzi</style></author><author><style face="normal" font="default" size="100%">Muhammad Hazzim bin Kosnin</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author><author><style face="normal" font="default" size="100%">Mohd Hafiz Arzmi</style></author><author><style face="normal" font="default" size="100%">Anisa Kusumawardani</style></author><author><style face="normal" font="default" size="100%">ASM Sabere</style></author><author><style face="normal" font="default" size="100%">Essam A Makky</style></author><author><style face="normal" font="default" size="100%">OE Ibrahim</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author><author><style face="normal" font="default" size="100%">Mohd Hafiz Arzmi</style></author><author><style face="normal" font="default" size="100%">Anisa Kusumawardani</style></author><author><style face="normal" font="default" size="100%">ASM Sabere</style></author><author><style face="normal" font="default" size="100%">Essam A Makky</style></author><author><style face="normal" font="default" size="100%">OE Ibrahim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Eurycoma Longifolia Jack (Tongkat Ali) Root Extract on salivary S. Mutans, Lactobacillus and Candida Albicans Isolated from High-Risk Caries Adult Patients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Eurycoma longifolia Jack</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibition</style></keyword><keyword><style  face="normal" font="default" size="100%">Salivary isolate</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">787-791</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Introduction: The roots of &lt;em&gt;E. longifolia jack&lt;/em&gt; (E.L.) or Tongkat Ali have been used in traditional medicine as well as supplements and food additives. Many chemical compounds have been detected in extracts of its roots which are believed to be responsible for its medicinal properties. In this study, our objectives were to study the effects of EL root extracts on the growth of &lt;em&gt;Streptococcus Mutans, Lactobacillus&lt;/em&gt; and &lt;em&gt;Candida Albicans &lt;/em&gt;isolated from saliva of adult patients with high caries risk. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The ethanolic extract of the root of this plant was tested against saliva isolated &lt;em&gt;Streptococcus Mutans, Lactobacillus&lt;/em&gt; and&lt;em&gt; Candida Albicans&lt;/em&gt; via disc diffusion assay at a concentration of 200mg/mL. The minimum inhibitory concentration was carried out by the standard broth microdilution method. Cell viability of test microorganisms against different concentration of the extract and inhibition zones were calculated.&lt;strong&gt; Results:&lt;/strong&gt; Disk diffusion assay showed positive zones of inhibition for all test microorganisms with &lt;em&gt;S. mutans, Lactobacillus &lt;/em&gt;and &lt;em&gt;C. albicans&lt;/em&gt; exhibiting zones of inhibition of 8.3 ± 0.7mm, 12.4 ± 2.4mm and 21.4 ± 2.7mm respectively. For minimum inhibitory concentration, the test microorganisms were tested at concentration of 250mg/ mL, 125mg/mL, 62.5mg/mL, 31.3mg/mL and 0mg/mL. The minimum inhibitory concentration showed that MIC of S. mutans was at 62.5mg/mL, Lactobacillus at 125mg/mL and C. albicans at 31.3mg/mL. Lastly, the cell viability results supported the MIC determined prior. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ethanol-based &lt;em&gt;E.&lt;/em&gt; &lt;em&gt;longifolia Jack&lt;/em&gt; root extract has an antimicrobial effect on the following microorganisms isolated from the saliva of high-risk caries adult patients: &lt;em&gt;S. mutans, Lactobacillus&lt;/em&gt; and &lt;em&gt;C. albicans.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">787</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhamad Iyad bin Ramzi1, Muhammad Hazzim bin Kosnin&lt;sup&gt;1&lt;/sup&gt;, Ghasak Ghazi Faisal&lt;sup&gt;2,&lt;/sup&gt;*, Mohd Hafiz Arzmi&lt;sup&gt;2&lt;/sup&gt;, Anisa Kusumawardani&lt;sup&gt;3&lt;/sup&gt;, ASM Sabere&lt;sup&gt;4&lt;/sup&gt;, Essam A. Makky&lt;sup&gt;5&lt;/sup&gt;, O.E. Ibrahim&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Kuliyyah of Dentistry, International Islamic University Malaysia (IIUM), MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Fundamental Dental and Medical Sciences, Kuliyyah of Dentistry, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Restorative Dentistry, Kuliyyah of Dentistry, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Kulliyyah of Pharmacy, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Industrial Sciences &amp;amp; Technology, Universiti Malaysia Pahang (UMP), Gambang, 26300 Kuantan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Faculty of Dentistry, Universiti Teknologi MARA, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Fitri Rachmaini</style></author><author><style face="normal" font="default" size="100%">Dian Ayu Juwita</style></author><author><style face="normal" font="default" size="100%">Rini Haryati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Giving Red-fleshed Watermelon Juice (Citrullus lanatus (Thunb.)) on Pregnant White Mice (Mus Musculus) Exposed by Monosodium Glutamate (MSG) Orally on the Number and Morphology of Fetus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fetus</style></keyword><keyword><style  face="normal" font="default" size="100%">Infertility</style></keyword><keyword><style  face="normal" font="default" size="100%">Lycopene</style></keyword><keyword><style  face="normal" font="default" size="100%">Monosodium glutamate</style></keyword><keyword><style  face="normal" font="default" size="100%">Red-fleshed watermelon</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">97-102</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Infertility can occur due to the presence of free radicals. One of the most popular of free radical is monosodium glutamate. Free radicals from monosodium glutamate can be prevented by antioxidant compounds. Red-fleshed-fleshed watermelon is a fruit that contains antioxidant compound such as lycopene. &lt;strong&gt;Aim: &lt;/strong&gt;This research was conducted to see the effect of red-fleshed-fleshed watermelon juice on the fetus including number, morphology, visual abnormalities and body weight of pregnant white mice exposed to monosodium glutamate solution orally. Total of 25 female white mice aged around 2-3 months were used as test animals. &lt;strong&gt;Methods: &lt;/strong&gt;Pregnant white mice were divided into 5 test groups. Group I and II served as negative controls (whithout treatment) and positive controls (exposed to monosodium glutamate solution orally at dose of 1g/kgBW). Group III was given a solution of monosodium glutamate orally at dose of 1 g/KgBW added red-fleshed-fleshed watermelon juice at dose of 1.4 g/kgBW. Group IV was given solution of monosodium glutamate orally at dose of 1 g/KgBW added red-fleshed-fleshed watermelon juice at dose of 4.2 g/kgBW. The research data were processed using the one-way ANNOVA test. &lt;strong&gt;Results: &lt;/strong&gt;The result showed that mice body weight, fetal number and morphology (body weight, body length, tail length, and head diameter) did not significantly influence (p&amp;gt;0.05). However, it significantly affected the weight gain of mice during pregnancy. However, it significantly affected the weight gain of mice during pregnancy day 6 to day 17 of pregnancy (p&amp;lt;0.05) and found abnormalities in the fetus such as low birth weight (LBW) and haemorrhage in group II and III. &lt;strong&gt;Conclusion:&lt;/strong&gt; It can be concluded that watermelon juice at dose of 2.8 g/kgBW and 4.2 g/kgBW are effective in ward offfree radicals from monosodium glutamate orally at dose of 1 g/kgBW.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">97</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dwisari Dillasamola, Fitri Rachmaini*, Dian Ayu Juwita, Rini Haryati &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ariiq Azmi Rofiqi Sulkhan</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author><author><style face="normal" font="default" size="100%">Sutriyo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Glycyrrhizin and Sappan Wood Extract on Chemically- Induced Oral Mucosal Ulcer: An in vivo Animal Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Caesalpinia sappan</style></keyword><keyword><style  face="normal" font="default" size="100%">Licorice</style></keyword><keyword><style  face="normal" font="default" size="100%">Stomatitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Triamcinolone Acetonide</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">909-915</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Stomatitis is the most common oral mucosal lesions characterized by round ulcers with yellow-white color and usually heals up to 14 days. Many recent studies have demonstrated that glycyrrhizin (GL) and &lt;em&gt;C. sappan&lt;/em&gt; extract (CSE) exhibits anti-inflammatory, anti-ulcer and antioxidant action but no study has demonstrated the effect on the oral mucosal ulcer.&lt;strong&gt; Objectives: &lt;/strong&gt;To evaluate the effect of GL and CSE in experimentally chemically induced oral mucosal ulcers using rats. &lt;strong&gt;Methods:&lt;/strong&gt; Male Sprague- Dawley rats were randomly distributed into seven groups: the control group, the comparison group of 0.1% triamcinolone acetonide (TCA), a single treatment group of 3% GL and 3% CSE, combination groups of 3% GL + CSE (1:1, 1:2, 2:1). The oral ulcer model was induced by 15 μL of 50% acetic acid. The clinical healing was evaluated by measuring the ulcer size and body weight from day 0–14 and evaluate the leukocyte number on days 0, 4, 9 and 14. Histological examination was conducted at the end of the treatment. &lt;strong&gt;Results:&lt;/strong&gt; The group of 0.1% TCA and GL:CSE (2:1) showed greater ulcer closure (&amp;gt;80%) and decreased leukocyte number since day 4 (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). Body weight loss was observed after ulcer initiation and started to increase after day 4 of treatment. While the histological examination showed similar tissue regeneration profile only from the GL:CSE (2:1) group with the healthy oral mucosa. &lt;strong&gt;Conclusion:&lt;/strong&gt; Combination treatment of GL:CSE (2:1) enhanced the closure of oral mucosal ulcer and demonstrate complete tissue regeneration.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">909</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ariiq Azmi Rofiqi Sulkhan&lt;sup&gt;1&lt;/sup&gt;, Abdul Mun’im&lt;sup&gt;2&lt;/sup&gt;, Sutriyo&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Program of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, Depok West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok West Java 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Faradila Amirabagya</style></author><author><style face="normal" font="default" size="100%">Rr Ayu Fitri Hapsari</style></author><author><style face="normal" font="default" size="100%">Endah Wulandari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Jatropha curcas L Seed Extract on AST/ALT Activity and The Central Vein Thickness in Liver</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">AST/ALT</style></keyword><keyword><style  face="normal" font="default" size="100%">Jatropha</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">The central vein thickness</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">66-72</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Jatropha is known as anti-inflammatory, antioxidant, anti-fungal, anti-cancer, and has coagulant activity. &lt;em&gt;Jatropha curcas&lt;/em&gt; (&lt;em&gt;Jatropha curcas&lt;/em&gt; L.) contains toxic compounds such as cursin, ricin and gallic acid. The liver has an important role in the process of metabolism and detoxification of xenobiotic substances. Repeated exposure to toxic compounds can damage hepatic hepatocytes. If the hepatocyte cells are injured, the AST/ALT enzyme is excreted and goes into the blood vessels, as an indicator of liver damage. This is also indicated by changes in the thickness of the central veins. This study aims to determine the effect of giving jatropha seed extract (&lt;em&gt;Jatropha curcas &lt;/em&gt;L.) on AST/ALT activity and the central vein thickness in the liver. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The research design was experimental, using male rats (&lt;em&gt;Rattus novergicus&lt;/em&gt; L) Sprague Dawley strain. The rats were given Jatropha seed extract at doses of 0, 5, 25, 50, and 250 mg/ KgBW for 28 days. To assess liver damage, measurements of AST/ ALT activity and thickness of the central vein in the liver were performed.&lt;strong&gt; Results:&lt;/strong&gt;&lt;em&gt; &lt;/em&gt;Jatropha&lt;em&gt; &lt;/em&gt;seed extract increased ALT activity at doses of 25.50, and 250 mg / KgBW compared to the control group (1.207; 1.62; 1.548 IU/L/ mg tissue x 10&lt;sup&gt;-3&lt;/sup&gt;); and increased AST activity at doses of 5, 25, 50, and 250 mg / KgBW compared to the control group (0.769; 0.974; 1.449; 1.185 IU/L/ mg tissue x 10&lt;sup&gt;-3&lt;/sup&gt;); Central vein thickness increased at doses of 25 and 50 mg/KgBW (6.17 and 4.9 μm) (Kruskal Wallis; p&amp;gt; 0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Jatropha curcas&lt;/em&gt; L. seed extract increased the activity of AST/ALT and the thickness of the central vein in the liver.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">66</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Faradila Amirabagya&lt;sup&gt;1&lt;/sup&gt;, Rr Ayu Fitri Hapsari&lt;sup&gt;2&lt;/sup&gt;, Endah Wulandari&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Students Faculty of Medicine and Biology Molecular, State Islmic University Syarif Hidayatullah, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Histology, State Islmic University Syarif Hidayatullah, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, State Islmic University Syarif Hidayatullah, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Natasha Yemima Situmorang</style></author><author><style face="normal" font="default" size="100%">Endah Zuraidah</style></author><author><style face="normal" font="default" size="100%">Ari Estuningtyas</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Mahkota Dewa (Phaleria macrocarpa) Leaf Extract on the Mucin 1 Expression in Mice Colonic Epithelial Cells Induced by Dextran Sodium Sulfate (DSS)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Colon epithelial cell</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammatory bowel Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Mahkota Dewa (Phaleria macrocarpa)</style></keyword><keyword><style  face="normal" font="default" size="100%">MUC 1 expression</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1509-1515</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Inflammatory bowel disease is a chronic inflammation caused by the malignant inflammation response and if not treated, could lead to colorectal cancer. One of the researched treatment is mahkota dewa (&lt;em&gt;Phaleria macrocarpa&lt;/em&gt;) leaf extract that has flavonoid compound known to reduce inflammation. This study was aimed to prove that mahkota dewa leaf extract could reduce inflammation of mice colon induced with dextran sodium sulfate (DSS) and observe MUC1 expression from colon epithelial crypt of Lieberkuhn. &lt;strong&gt;Methods&lt;/strong&gt;: This was a laboratory experiment using biological material (paraffin block) taken from 28 mice and divided into 5 groups: normal, aspirin, low and high dose mahkota dewa, and negative control. They were processed into immunohistochemistry and stained microscopic slides. Afterwards, they were observed with 400x magnification and 5 field-of-view of mice colon crypt of lieberkuhn. Then MUC1 expression was counted using ImageJ to obtain mean immunohistochemistry score and analyzed with SPSS. &lt;strong&gt;Results:&lt;/strong&gt; There were significant reduction of MUC1 expressions from normal, aspirin, and high dose mahkota dewa groups compared to the negative control group. The result shown MUC1 expression from high dose mahkota dewa (M=149.90,SD=3.81) and aspirin (M=158.92,SD=5.28) were closer to normal group (M=148.02,SD=5.28). There were no significant results between negative (M=175.39,SD=14.30) and low dose mahkota dewa group (M=149.90,SD=5.02).&lt;strong&gt; Conclusion:&lt;/strong&gt; There was a reduction of MUC1 expression in DSS-induced mice colonic epithelial cells for high dose mahkota dewa group. This shown that high dosage mahkota dewa leaf extract could reduce inflammation like aspirin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1509</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1-3,*&lt;/sup&gt;, Natasha Yemima Situmorang&lt;sup&gt;4&lt;/sup&gt;, Endah Zuraidah&lt;sup&gt;5&lt;/sup&gt;, Ari Estuningtyas&lt;sup&gt;6&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2,7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine – Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Center, Indonesia Medical Education and Resesarch Institute (IMERI), Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Human Cancer Research Center, IMERI, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine – Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tridiganita Intan Solikhah</style></author><author><style face="normal" font="default" size="100%">Gahastanira Permata Solikhah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alloxan</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Muntingia calabura leaf</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1450-1455</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective&lt;/strong&gt;: To evaluate the effect of &lt;em&gt;Muntingia calabura&lt;/em&gt; L. leaf extract on the blood glucose level and weight of alloxan-induced diabetic mice. &lt;strong&gt;Methods:&lt;/strong&gt; The mice were injected using 150mg/kg of alloxan intraperitoneally to induce diabetes. Blood glucose level was tested before alloxan injection and 5 days after injection to confirm diabetes development. &lt;em&gt;M. calabura&lt;/em&gt; leaf extract with 100 and 300 mg/kg and 600 μg/kg of glibenclamide was given orally for 14 days. &lt;strong&gt;Results:&lt;/strong&gt; The statistical results showed a significant decrease in blood glucose level, especially on day-7 and day-14 in the &lt;em&gt;M. calabura &lt;/em&gt;leaf extract treatment group and glibenclamide treatment group compared to the model control group. There was an increase of weight on day-7 and day-14 in the&lt;em&gt; M. calabura &lt;/em&gt;leaf extract group and a significant decrease in weight on day-7 in the glibenclamide group compared to the model control group. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;M. calabura &lt;/em&gt;leaf extract had a significant antidiabetic effect that can normalize the weight of alloxan-induced diabetic mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1450</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tridiganita Intan Solikhah&lt;sup&gt;1,*&lt;/sup&gt;, Gahastanira Permata Solikhah&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Cahaya Petclinic, Mojokerto, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tridiganita Intan Solikhah</style></author><author><style face="normal" font="default" size="100%">Gahastanira Permata Solikhah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alloxan</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Muntingia calabura leaf</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1450-1455</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the effect of&lt;em&gt; Muntingia calabura &lt;/em&gt;L. leaf extract on the blood glucose level and weight of alloxan-induced diabetic mice. &lt;strong&gt;Methods:&lt;/strong&gt; The mice were injected using 150mg/kg of alloxan intraperitoneally to induce diabetes. Blood glucose level was tested before alloxan injection and 5 days after injection to confirm diabetes development. &lt;em&gt;M. calabura&lt;/em&gt; leaf extract with 100 and 300 mg/kg and 600 μg/kg of glibenclamide was given orally for 14 days.&lt;strong&gt; Results:&lt;/strong&gt; The statistical results showed a significant decrease in blood glucose level, especially on day-7 and day-14 in the &lt;em&gt;M. calabura &lt;/em&gt;leaf extract treatment group and glibenclamide treatment group compared to the model control group. There was an increase of weight on day-7 and day-14 in the&lt;em&gt; M. calabura&lt;/em&gt; leaf extract group and a significant decrease in weight on day-7 in the glibenclamide group compared to the model control group.&lt;strong&gt; Conclusion&lt;/strong&gt;: &lt;em&gt;M. calabura&lt;/em&gt; leaf extract had a significant antidiabetic effect that can normalize the weight of alloxan-induced diabetic mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1450</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tridiganita Intan Solikhah&lt;sup&gt;1,*&lt;/sup&gt;, Gahastanira Permata Solikhah&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA. 2Cahaya Petclinic, Mojokerto, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Baiqi Nur Hairi</style></author><author><style face="normal" font="default" size="100%">Nadar Sukri Lubis</style></author><author><style face="normal" font="default" size="100%">Tri Wahyuni Lestari</style></author><author><style face="normal" font="default" size="100%">Putri Reno Intan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Sambiloto and Spirulina Combination on Mucin-1 Protein Expression in Medial Colon of Plasmodium berghei ANKA Infected Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Medial colon</style></keyword><keyword><style  face="normal" font="default" size="100%">Muc-1</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasmodium berghei Anka</style></keyword><keyword><style  face="normal" font="default" size="100%">Sambiloto</style></keyword><keyword><style  face="normal" font="default" size="100%">Spirulina</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1359-1365</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Malaria still be health problem in the world, especially in Eastern Indonesia. Malaria’s inflammation and metabolism defect can cause colonic damage, such as enhancement Muc-1 protein expression and goblet cells hyperplasia. Sambiloto and spirulina combination as antiinflammatory and antioxidative agent can prevent medial colon damage &lt;em&gt;Plasmodium berghei &lt;/em&gt;ANKA infected mice. The aim of the study to show the effect of sambiloto and spirulina combination on Muc-1 protein activity in medial colon &lt;em&gt;Plasmodium berghei&lt;/em&gt; ANKA infected mice. This study use preserve male Swiss Webser mice colonic tissue which has inoculated by&lt;em&gt; Plasmodium berghei &lt;/em&gt;ANKA, whose treatment group include positive control (dehyroartemisin piperaquine), negative control (carboxymethil cellulose), AP (sambiloto), AP+ES (sambiloto+spirulina extract), and AP+PS (sambiloto+spirulina powder) and terminated after 28 days of treatment. Colonic tissue was stained with immunohistochemistry and observed using light microscope (400x) in five different field and was analyzed with ImageJ® sowtware, and statisitcal analysis was done with SPSS 20.0. According to One Way ANOVA and Duncan posthoc test, only AP+PS(120,98 ±3,37), which significantly difference between negative control, AP, and AP+ES group. Meanwhile, between DHP, AP+PS group not significantly differenece. Sambiloto extract and spirulina powder combination can reduce Muc-1 protein expression in medial colon &lt;em&gt;Plasmodium berghei &lt;/em&gt;ANKA infected mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1359</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1-4&lt;/sup&gt;,*, Baiqi Nur Hairi&lt;sup&gt;5&lt;/sup&gt;, Nadar Sukri Lubis&lt;sup&gt;6&lt;/sup&gt;, Tri Wahyuni Lestari&lt;sup&gt;7&lt;/sup&gt;, Putri Reno Intan&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Parasitology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;National Institute of Health Research and Development, Ministry of Health of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mouchira Abdel Salam</style></author><author><style face="normal" font="default" size="100%">Hala M. Raslan</style></author><author><style face="normal" font="default" size="100%">Doha A. Mohamed</style></author><author><style face="normal" font="default" size="100%">Aliaa Elgendy</style></author><author><style face="normal" font="default" size="100%">Rehab A. Hussein</style></author><author><style face="normal" font="default" size="100%">Omneya Moguib</style></author><author><style face="normal" font="default" size="100%">Maha Abdelhadi</style></author><author><style face="normal" font="default" size="100%">Rokia Abd El-Shafy Soliman El-Banna</style></author><author><style face="normal" font="default" size="100%">Karem Fouda</style></author><author><style face="normal" font="default" size="100%">Safenaz Y. El Sherity</style></author><author><style face="normal" font="default" size="100%">Emad N. Zikri</style></author><author><style face="normal" font="default" size="100%">Nagwa M. Ammar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Soybean on Bone Health and Some Metabolic Parameters in Postmenopausal Egyptian Women</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bone health</style></keyword><keyword><style  face="normal" font="default" size="100%">Bone mineral density</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypocholesterolemic effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin resistance</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolic parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Soybean</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">688-697</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Great concern has been raised recently concerning the therapeutic impact of soybean. The present study aims to investigate the effects of soybean on bone health and metabolic parameters in postmenopausal women. &lt;strong&gt;Methods:&lt;/strong&gt; In this clinical study, 72 healthy postmenopausal women aged between 45-65 years were given soybean bioactive fraction 2 capsules (500mg each) daily for 24 weeks. Each capsule contained 31.25 mg proteins, 3.2 mg carbohydrates and 4.84 mg isoflavones. Blood pressure, bone mineral density, plasma osteocalcin (OCN), telopeptides of collagen type I (CTX), fasting insulin and blood glucose, lipid profile, serum creatinine, alanine transaminase (ALT), aspartate transaminase (AST), and TSH were assessed prior and after the period of the study. Insulin resistance was calculated by homeostatic model assessment-IR formula (HOMA-IR). &lt;strong&gt;Results:&lt;/strong&gt; Soy ingestion resulted in a significant increase in T score of the hip and OCN; recording -1.97±0.13/-1.76±0.12 and 22.44±0.60ng/ml/30.93±0.57ng/ml before/after treatment, respectively. A marked decrease was also detected in CTX from 2.22±0.10ng/ml to 1.48±0.08ng/ml. With regard to metabolic parameters, there was a significant decrease in fasting insulin (5.40±0.62uU/ml vs 4.15±0.45uU/ ml), however, fasting glucose and HOMA-IR showed no significant alterations. Lipid profile displayed remarkable decline in total cholesterol (188.86±7.23mg/dl vs 159.60±4.72mg/dl, triglycerides (97.09±5.23mg/dl vs 83.56±4.27mg/dl), LDL-c (75.60±3.06mg/dl vs 63.95±1.86mg/ dl) accompanied with a significant elevation in HDL-c (53.09±0.88 vs 65.81mg/dl±0.80mg/ dl). A significant decrease in both TSH (1.97±0.13 uIU/ml vs 1.40±0.08 uIU/ml) and serum creatinine (0.82±0.02mg/dl vs0.77±0.02mg/dl) was also noticed. &lt;strong&gt;Conclusion:&lt;/strong&gt; Consumption of soy improves bone health, reduces cardiovascular risk with no adverse effects on kidney, liver or thyroid functions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">688</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mouchira Abdel Salam&lt;sup&gt;1&lt;/sup&gt;, Hala M. Raslan&lt;sup&gt;2&lt;/sup&gt;, Doha A. Mohamed&lt;sup&gt;3&lt;/sup&gt;, Aliaa Elgendy&lt;sup&gt;1&lt;/sup&gt;, Rehab A. Hussein&lt;sup&gt;4,&lt;/sup&gt;*, Omneya Moguib&lt;sup&gt;2&lt;/sup&gt;, Maha Abdelhadi&lt;sup&gt;2&lt;/sup&gt;, Rokia Abd El- Shafy Soliman El-Banna&lt;sup&gt;5&lt;/sup&gt;, Karem Fouda&lt;sup&gt;3&lt;/sup&gt;, Safenaz Y. El Sherity&lt;sup&gt;5&lt;/sup&gt;, Emad N. Zikri&lt;sup&gt;1&lt;/sup&gt;, Nagwa M. Ammar&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Complementary Medicine Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Internal Medicine Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Nutrition and Food Sciences Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Pharmacognosy Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Biological Anthropology Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author><author><style face="normal" font="default" size="100%">Joko Wahyuwibowo</style></author><author><style face="normal" font="default" size="100%">Mochammad Navi Suharto</style></author><author><style face="normal" font="default" size="100%">Bagus Haruno Enggartiasto</style></author><author><style face="normal" font="default" size="100%">Mohammad Iqbal Raka Ortanto</style></author><author><style face="normal" font="default" size="100%">Arrizki Azka Pratama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Tender Coconut Water (TCW) on TNF-α, IL-1 and IL-6 in Streptozotocin (STZ) and Nicotinamid (NA) Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-1</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Tender coconut water</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">500-505</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes Mellitus (DM) is characterized by an increase in blood sugar levels also known as hyperglycemia. Continuous hyperglycemia can increase the production of Reactive Oxygen Species (ROS). ROS causes oxidative stress and increases the formation of TNF-α expression as a marker of inflammation. Tender coconut water is rich in sources of free amino acids, L-arginine and vitamin C which can prevent oxidative stress. &lt;strong&gt;Aim and Objectives:&lt;/strong&gt; This research to investigate the effect of tender coconut water on TNF-α, IL-1 and IL-6 in Streptozotocin (STZ) and Nicotinamid (NA) induced diabetic rats. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Experimental research design using posttest control group design. Twenty four male wistar strain rats were used in this study were divided randomly into 4 groups, which are group K1 (control); K2 (DM type 2); K3 (DM type 2+ Glibenclamid 0,18mg/200grBW); K4 (DM type 2+ tender coconut water 8mL/200gr BW). Type 2 Diabetes Mellitus were induced using Streptozotocin (STZ) 65mg/kg body weight and Nicotinamid 230 mg/kg body weight. The administration of tender coconut water were given on day 3 after DM condition is reached, given daily for 4 weeks with dose of 8 mL/200 gr BW. Data on of TNF-α , IL-1 and IL-6 levels were analyzed by One Way Anova. &lt;strong&gt;Result: &lt;/strong&gt;Average TNF-α level, IL-1 level and IL-6 level in Group 2 increased compared to Group 1 , in Group 3 it decreased compared to Group 2 as well as in Group 4 .The results of the analysis has the p values &amp;lt;0.05. &lt;strong&gt;Conclusion:&lt;/strong&gt; Administration of tender coconut water can be decreasing of TNF-α, IL-1 and IL-6 levels in wistar strain male rats with type 2 Diabetes Mellitus.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">500</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siti Thomas Zulaikhah&lt;sup&gt;1,&lt;/sup&gt;*, Joko Wahyuwibowo&lt;sup&gt;1&lt;/sup&gt;, Mochammad Navi Suharto&lt;sup&gt;2&lt;/sup&gt;, Bagus Haruno Enggartiasto&lt;sup&gt;2&lt;/sup&gt;, Mohammad Iqbal Raka Ortanto&lt;sup&gt;2&lt;/sup&gt;, Arrizki Azka Pratama&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Central Java 50112, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Student Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Central Java 50112, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Student Program Master of Biomedical Science Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Central Java 50112, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tanti Azizah Sujono</style></author><author><style face="normal" font="default" size="100%">Ika Trisharyanti Dian Kusumowati</style></author><author><style face="normal" font="default" size="100%">Rima Munawaroh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Jamaican cherry (Muntingia calabura L.) Fruits Extract on Immunoglobulin G Levels and Hematological Profiles in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hematological profile</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis B vaccine</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunoglobulin G</style></keyword><keyword><style  face="normal" font="default" size="100%">Jamaican cherry (Muntingia calabura L.)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">535-541</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Jamaican cherry (&lt;em&gt;Muntingia calabura&lt;/em&gt; L.) fruits contain potential immunomodulatory agents such as phenolic and flavonoid compounds. However, previous research was limited only to the effect of Jamaican cherry fruits on non-specific immune response namely the phagocytic index. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to determine the immunomodulatory activity of Jamaican cherry fruits against specific immune response by measuring the antibody formation named immunoglobulin G (IgG). In addition, the hematological profile of the animals induced by hepatitis B vaccine was also evaluated. &lt;strong&gt;Materials and methods: &lt;/strong&gt;forty male mice were grouped into 8 groups consist of control, treatment, and standard groups. Control group was given CMC-Na 0.5%, six treatment groups were each given either the methanol extract of Jamaican cherry fruits (MEJF), or ethyl acetate fraction of Jamaican cherry fruits (EAJFJ) with the doses of 50, 100, and 200 mg/kg BW (each dose for one group), and levamisole was given to the standard group. Levamisole and extract of Jamaican cherry fruits were prepared as a suspension in CMCNa 0.5% and administered orally for 15 days. Mice were induced with hepatitis B vaccine intraperitoneally twice. The levels of IgG, hematological profiles, and organ index were measured on the 16&lt;sup&gt;th&lt;/sup&gt; day. &lt;strong&gt;Results:&lt;/strong&gt; The administration of MEJF and EAFJF stimulated IgG production significantly compared to the control group (p&amp;lt;0.05). Meanwhile, the MEJF and EAFJF did not influence the hematological profile. An increase of the spleen index was found in the EAFJF group compared to the control. Both MEJF and EAFJF were shown to have flavonoids, phenolics, and triterpenoids contents. &lt;strong&gt;Conclusion: &lt;/strong&gt;MEJF and EAFJF possessed immunostimulant properties by increasing the specific (humoral) immune response (IgG) after induction with the hepatitis B vaccine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">535</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tanti Azizah Sujono&lt;sup&gt;1,&lt;/sup&gt;*, Ika Trisharyanti Dian Kusumowati&lt;sup&gt;2&lt;/sup&gt;, Rima Munawaroh&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, 57162, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, 57162, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, 57162, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sofiah Yunita Radjah</style></author><author><style face="normal" font="default" size="100%">Kunia Sari Setio Putri</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Elastase Inhibitory Activity, Determination of Total Polyphenol and Determination of Total Flavonoids and Pharmacognosy Study of Faloak Plant (Sterculia quadrifida R.Br) from East Nusa Tenggara-Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Elastase inhibitory</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenol</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterculia quadrifida</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">758-764</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Faloak (&lt;em&gt;Sterculia quadrifida&lt;/em&gt; R. Br) is one of the typical plants of East Nusa Tenggara (NTT). Faloak contain flavonoid and polyphenol compounds, and show strong antioxidants activity which potentially correlated with its elastase inhibitory activity. Therefore, in this research, elastase inhibitory activity on various part of Faloak plant was investigated. &lt;strong&gt;Objective:&lt;/strong&gt; The purpose of this research was to investigate the elastase inhibitory activity, determination of total polyphenol, determination of total flavonoids, and also pharmacognosy characterization of Faloak leaves, roots, stems and stem barks. &lt;strong&gt;Methods:&lt;/strong&gt; Sample of leaves, roots, stems, and stem barks were extracted by 70% ethanol using ultrasound-assisted extraction (UAE). Phytochemical screening, microscopic identification and elastase inhibitory activity testing were performed on the leaves, roots, stems, and stem barks extract. This extract with the highest elastase inhibitory activity was then determined for its total polyphenol content and of total flavonoids content. &lt;strong&gt;Results:&lt;/strong&gt; UAE method with 70% ethanol successfully extracted active compounds from leaves, stems, roots, and stem barks of Faloak. Extract of all Faloak parts contained alkaloids, flavonoids, tannins, terpenes, and glycosides. The extract of Faloak stem barks showed the strongest elastase inhibitory activity as compared to the extract from other parts, with IC&lt;sub&gt;50&lt;/sub&gt; of 73.7 μg/mL. Alkaloid, flavonoid, tannin, terpene, and glycoside were detected as secondary metabolite in the extract of leaves, roots, stems and stem barks. The extract of Faloak stem barks showed the highest elastase inhibitory activity with IC50 73.7 μg/mL. The total flavonoids and total polyphenol content of Faloak stem bark extract were respectively 28.75 mg/gram and 45.25 mg/gram extract. &lt;strong&gt;Conclusion: &lt;/strong&gt;The 70% ethanol extract of leaves, roots, stems, and stem barks of Faloak showed elastase inhibitory activity, and stem barks extract showed the strongest activity. Faloak stem barks extract can be considered as potential to be developed as active compound in anti-aging product, both in cosmetic and pharmaceutical dosage forms.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">758</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sofiah Yunita Radjah&lt;sup&gt;1&lt;/sup&gt;, Kunia Sari Setio Putri&lt;sup&gt;2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Phytochemistry, and Natural Products, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Misgiati Misgiati</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Sentot Joko Raharjo</style></author><author><style face="normal" font="default" size="100%">Sukardiman Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ergosterol Isolated from Agaricus blazei Murill N-Hexane Extracts as Potential Anticancer MCF-7 Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Agaricus blazei</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Egosterol</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7 cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Murill extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">418-426</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Extracts and some of the &lt;em&gt;Agaricus blazrei &lt;/em&gt;Murill isolates have potential anticancer. Ergosterol isolate from &lt;em&gt;Amaouroderma rude&lt;/em&gt; can also inhibit the growth of MDA-MB-231 cancer cells through apoptotic pathways by increasing FOXO&lt;sub&gt;3&lt;/sub&gt; expression, while its potency against MCF-7 cells has not been reported. The purpose of this study was to isolate, determine the structure, determine the anticancer activity of MCF-7 cells, and the isolate mechanism by apoptosis from one of isolates the n-hexane &lt;em&gt;A.blazei &lt;/em&gt;Murill extracts. This research method includes the isolation of compounds from &lt;em&gt;A.blazei &lt;/em&gt;Murill extract by chromatography method guided using Bioactivity Guided Isolation. The structure elucidation of structure isolates used UV, NMR and MS spectroscopy. Anticancer activity test using the MTT cytotoxic test. Eludation of UV, NMR and MS structures showed a ergostrerol. The anticancer activity test showed IC&lt;sub&gt;50&lt;/sub&gt; values of 43.10 μg/ mL with the strong cytotoxic category. The mechanism of action is to increase apoptosis induction through inhibition of the cell cycle in the G2/ M phase. The conclusion of the isolated compound was ergosterol with an IC&lt;sub&gt;50&lt;/sub&gt; value of 43.10 μg / mL with an increased apoptosis induction mechanism through inhibition of the cell cycle in the G2/ M phase.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">418</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Misgiati Misgiati&lt;sup&gt;1,2&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;3&lt;/sup&gt;, Sentot Joko Raharjo&lt;sup&gt;2&lt;/sup&gt;, Sukardiman Sukardiman&lt;sup&gt;4,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Post Graduate Student of Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Airlangga University, Surabaya 6011, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Academic of Pharmacy and Food Analyst of Putra Indonesia Malang, Jl. Barito 5 Malang 65123, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Natural Product Medicine Research and Development, Institute of Tropical Disease, Airlangga University, Surabaya 6011, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Airlangga University, Surabaya 6011, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Resta Angelia</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethanol Extract Activity of Pegagan Embun (Hydrocotyle sibthorpioides L.) Against Hematopoietic on Anemic Male White Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract of Hydrocotyle sibthorpioides L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematocrit</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Reticulocytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">866-873</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) is known to have many benefits, including as a blood booster. This study aims to determine the activity of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) on the formation of red blood cells. The parameters include the number of erythrocytes, reticulocytes, hemoglobin levels, and hematocrit values in anemic male white mice induced by chloramphenicol 130 mg/kg for 14 days. &lt;strong&gt;Methods:&lt;/strong&gt; Anemic mice consisted of 4 groups, namely the first group was given physiological NaCl, the second, third, and fourth groups were given ethanol extract of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) at a dose of 10, 50 and 100 mg/kgper oral every day, for 14 days. Observations were made on days 0, 14, 21, and 28. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that administration of pegagan embun extracts at a dose of 10, 50, and 100 mg/kgto anemic male white mice significantly increase the number of erythrocyte cells, the number of reticulocytes, the hemoglobin levels, and the hematocrit values (p &amp;lt;0.05). Increasing the dose and duration of pegagan embun extract administration could provide a more significant increase in the hematopoietic parameters (p &amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt;It can be concluded that the extract of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) can be used to treat anemia in male white mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">866</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Dwisari Dillasamola, Elsa Badriyya, Resta Angelia, Yufri Aldi&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, University Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tizazu Gebre</style></author><author><style face="normal" font="default" size="100%">Bhaskarrao Chinthapalli</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Study of the Traditional Use and maintenance of Medicinal Plants by the People of Aleta-Chuko Woreda, South Ethiopia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Indigenous knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant species</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional healers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1097-1108</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Over centuries, indigenous people have developed their own locality specific knowledge on plant use, management and conservation. However, this valuable traditional knowledge on utilization of plants was not much documented and hence, most of the indigenous knowledge acquired by the local people has been passed on from generation to generation by the word of mouth. Ethnobotanical study is of the use and maintenance of traditional medicinal plant species by the people of Aleta Chuko woreda, South Ethiopia. The study made an attempt to assess the indigenous knowledge that equips the community to identify the medicinal plants, formulate the medicines and subsequently administer the curatives used to treat various human and livestock diseases as the threats that could affect their sustainable use. &lt;strong&gt;Methods: &lt;/strong&gt;A total of 100 informants (85 males and 15 females) were selected to collect information on medicinal plant use from five selected kebeles by using non-probability sampling method. Relevant ethnobotanical information was collected through semi-structured interview, field observation and group discussion. Data was analyzed using descriptive statistics and simple linear correlation coefficient. The study was carried out from September, 2017 to July, 2018. &lt;strong&gt;Results:&lt;/strong&gt; A total of 53 medicinal plant species representing 49 genera and 30 plant families used in the treatment of 92 (81 human and 11 livestock) different ailments. The plant families Lamiaceae, Rutaceae, and Asteraceae were the most dominant groups. Out of the total recorded medicinal plant species, 79%, 11 % and 10%, were used for treating human, livestock and both humans and livestock health problems respectively. Stomachache and cough were the most common health problems of the study area affecting both humans and animals. 60% of the medicinal plant species were collected from the wild/forest and the remaining 40%were collected from the Homegardens. Herbs were the dominant medicinal plant habit, followed by shrubs and trees. Leaves are the dominant plant part used in formulating curative preparations. The most dominant methods of preparation were crushing and pounding and 70.5% is the dominant route of oral administration. &lt;em&gt;Fagaropsis angolensis&lt;/em&gt; was the most effective curatives species against stomach ache, the most common human disease in the study area, followed by &lt;em&gt;Leonotis nepetifolia,&lt;/em&gt; and &lt;em&gt;Ajuga integrifolia,&lt;/em&gt; &lt;em&gt;Ocimum lamiifolium&lt;/em&gt; was the most preferred medicinal plant to treat headache followed by Echinops kebericho and&lt;em&gt; Salvia nilotica. &lt;/em&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; The Coffee-Enset based home gardens which characterize the study area make a substantial contribution to the conservation of medicinal plants species. In order to conserve the traditional medicinal plant species of the study area, community-based &lt;em&gt;in-situ&lt;/em&gt; and&lt;em&gt; ex-situ&lt;/em&gt; conservation actions, awareness creation in the younger members, and strengthening home gardens and other components of the agro-forestry systems to be used as repositories of medicinal plant species and alternative conservation sites are recommended.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1097</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tizazu Gebre, Bhaskarrao Chinthapalli*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biology, College of Natural Sciences, Arba Minch University, P.O. Box 21, Arba Minch, ETHIOPIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammad Amil Zulhilmi Benjamin</style></author><author><style face="normal" font="default" size="100%">Shean Yeaw Ng</style></author><author><style face="normal" font="default" size="100%">Fiffy Hanisdah Saikim</style></author><author><style face="normal" font="default" size="100%">Nor Azizun Rusdi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotany and Traditional Knowledge of Bamboos (Poaceae: Bambusoideae) in Asia and Their Applications in the Complementary and Alternative Medicine: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asia</style></keyword><keyword><style  face="normal" font="default" size="100%">Bambusoideae</style></keyword><keyword><style  face="normal" font="default" size="100%">Complementary and alternative medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional knowledge.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1751-1762</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Plants are considered a great source of various herbal medicines in the treatment of certain diseases and ailments. There is a growing interest in the utilization of indigenous medicinal plants as the source for complementary and alternative medicine (CAM) due to the significant contribution of plant-based materials to the pharmaceutical field. Bambusoideae is a large grass family of Poaceae, comprising approximately 119 genera and 1482 described species. About 70% of the bamboo forests are covered throughout Asia. This study aims to provide an informative review of the ethnobotanical significance and traditional knowledge of medicinal plants belonging to the Bambusoideae. This review comprises informative data on medicinal plants, their uses, and parts used by indigenous people and native communities in Asian regions. In line with this review, bamboo has made significant contributions to the ethnobotanical field, specifically as therapeutics for specific diseases. Ethnobotanical data has also made a successful contribution to the CAM. Therefore, the present review on ethnobotany and traditional knowledge of bamboo is expected to have many benefits and could be a good starting point for future work in the pharmaceutical field, both locally and internationally.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1751</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mohammad Amil Zulhilmi Benjamin&lt;sup&gt;1&lt;/sup&gt;, Shean Yeaw Ng&lt;sup&gt;1&lt;/sup&gt;, Fiffy Hanisdah Saikim&lt;sup&gt;1&lt;/sup&gt;, Nor Azizun Rusdi&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chandra Mohini Nemkul</style></author><author><style face="normal" font="default" size="100%">Gan B Bajracharya</style></author><author><style face="normal" font="default" size="100%">Hayato Maeda</style></author><author><style face="normal" font="default" size="100%">Ila Shrestha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnomedicinal Knowledge Verification for the Antidiarrheal and Antioxidant Effects of Rhus chinensis Mill. Fruits with Identification of Thirty Constituents</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial susceptibility assay</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH radical scavenging assay</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrogen peroxide scavenging activity</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">37-43</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Ethnobotanical survey in the rural villages in Nepal revealed that the fruits of&lt;em&gt; Rhus chinensis&lt;/em&gt; Mill. have been using for the treatment of diarrhea and dysentery. &lt;strong&gt;Objective: &lt;/strong&gt;To evaluate antimicrobial and antioxidant effects, and identification of chemical constituents in the fruits of &lt;em&gt;R. chinensis&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Phytochemical screening was performed on the hexane and 70% methanolic extracts of the sample followed by gas chromatographymass spectrometry (GC-MS). Total phenolic content (TPC) was estimated using Folin-Ciocalteu method. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical and hydrogen peroxide scavenging assays were used to evaluate the antioxidant capacity. Antibacterial effect was estabilished by the Agar well diffusion assay. &lt;strong&gt;Results: &lt;/strong&gt;A total of 30 compounds belonging to phenolics, anhydrides, aldehydes, fatty acids and hydrocarbons were identified in the extracts. The TPC value of 123.52±1.29 mg GAE/g dry extract was estimated. IC&lt;sub&gt;50&lt;/sub&gt; value of 135.54±0.82 μg/mL was calculated in DPPH free radical scavenging assay. Scavenging of 42.69±0.1% DPPH free radical and 63.20±1.48% hydrogen peroxide at 100 μg/mL concentration of 70% methanolic extract were estimated. The maximum zone of inhibition (ZOI) observed was 23.00±0.57 mm against &lt;em&gt;Escherichia coli&lt;/em&gt; at loading dose of 5 mg of the extract.&lt;strong&gt; Conclusion: &lt;/strong&gt;All together 30 compounds were identified in the fruits. The extracts efficiently inhibited the growth of &lt;em&gt;E. coli &lt;/em&gt;and &lt;em&gt;Shigella dysenteriae&lt;/em&gt; verifying the rural knowledge. At the same time, the extracts displayed efficient antioxidant activity. The phytochemicals identified were responsible for these activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">37</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Chandra Mohini Nemkul&lt;sup&gt;1&lt;/sup&gt;, Gan B Bajracharya&lt;sup&gt;2,&lt;/sup&gt;*, Hayato Maeda&lt;sup&gt;3&lt;/sup&gt;, Ila Shrestha&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departement of Botany, Tri-Chandra Multiple Campus, Tribhuvan University, Ghantaghar, Kathmandu, NEPAL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Science, Nepal Academy of Science and Technology, Khumaltar, Lalitpur, NEPAL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Agriculture and Life Science, Hirosaki University, 3-Bunkyo-cho, Hirosaki, Aomori 036-8561, JAPAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Botany, Patan Multiple Campus, Tribhuvan University, Patandhoka, Lalitpur, NEPAL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ruqiah Ganda Putri Panjaitan</style></author><author><style face="normal" font="default" size="100%">Titin</style></author><author><style face="normal" font="default" size="100%">Yohanes Gatot Sutapa Yuliana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethno-Medicinal Plants Used for Medication of Jaundice by The Chinese, Dayak, and Malays Ethnic in West Kalimantan, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Jaundice</style></keyword><keyword><style  face="normal" font="default" size="100%">Local Wisdom</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">916-923</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Knowledge in the utilization of plants as medicine is local wisdom passed down from generation to generation. This study aims to make an inventory of plants that is efficacious in overcoming jaundice which is used by ethnic Chinese, Dayak, and Malay people in West Kalimantan. This research applies ethnobotany and medical ethnobiology approaches by using observation techniques, semi-structural interviews, also recording and documenting plant species to overcome jaundice. There were 23 types of medicinal plants used by ethnic Chinese, Dayak, and Malay people to overcome jaundice. The 23 types of plants obtained were tebu hitam (&lt;em&gt;Saccharum officinarum&lt;/em&gt; L.), pisang mas (&lt;em&gt;Musa paradisiaca &lt;/em&gt;L.), kacang hijau (&lt;em&gt;Vigna radiata &lt;/em&gt;L.), bawang dayak (&lt;em&gt;Eleutherine palmifolia &lt;/em&gt;(L.) Merr.), temulawak (&lt;em&gt;Curcuma xanthorrhiza&lt;/em&gt; Roxb.), lipan-lipan (&lt;em&gt;Chrysopogon aciculatus&lt;/em&gt; (Retz.) Trin), ciplukan (&lt;em&gt;Physalis angulata &lt;/em&gt;L.), cha chen chou/ sawi (&lt;em&gt;Plantago mayor&lt;/em&gt; L.), inai (&lt;em&gt;Lawsonia inermis&lt;/em&gt; L), kunyit (&lt;em&gt;Curcuma domestica&lt;/em&gt; Val.), kelapa gading (&lt;em&gt;Cocos eburen&lt;/em&gt; Durch), belimbing manis (&lt;em&gt;Averrhoa Carambola &lt;/em&gt;L.), ilalang (&lt;em&gt;Imperata cylindrica&lt;/em&gt; (L) Beauv.), sia li chi o kin/putri malu kuning (&lt;em&gt;Neptunia oleracea&lt;/em&gt; Lour.), ketepeng (&lt;em&gt;Senna alata&lt;/em&gt; (L.) Roxb.), putri malu bunga ungu (&lt;em&gt;Mimosa pudica &lt;/em&gt;L.), stet ma thio kin/bunga kancing (&lt;em&gt;Urena lobata &lt;/em&gt;L.), tebu karak (&lt;em&gt;Saccharum officinarum&lt;/em&gt; L.), kumis kucing (&lt;em&gt;Orthosiphon aristatus &lt;/em&gt;(Blume) Miq.), empedu tanah/sambiloto (&lt;em&gt;Andrographis paniculata&lt;/em&gt; (Burm.f.) Wall. Ex Nees), pegage/pegagan (&lt;em&gt;Centella asiatica&lt;/em&gt; L. Urban), kai kut chou/tulang ayam (&lt;em&gt;Clinacanthus nutans &lt;/em&gt;(Burm.f.) Lindau), and bambu kuning (Bambusa vulgaris Schrad.).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">916</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ruqiah Ganda Putri Panjaitan&lt;sup&gt;1,&lt;/sup&gt;*, Titin&lt;sup&gt;1&lt;/sup&gt;, Yohanes Gatot Sutapa Yuliana&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Tanjungpura University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;English Education Department, Faculty of Teacher Training and Education, Tanjungpura University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thanh Ha Tuan Nguyen</style></author><author><style face="normal" font="default" size="100%">Ngan Nguyen Hoang</style></author><author><style face="normal" font="default" size="100%">Xuan Thanh Nguyen</style></author><author><style face="normal" font="default" size="100%">Binh Nhu Do</style></author><author><style face="normal" font="default" size="100%">Son Trinh The</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluate the Effect of Herbal Extract Remedy for Treatment of Liver Cirrhosis in in-vitro</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CCl4</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver cirrhosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Silymarin</style></keyword><keyword><style  face="normal" font="default" size="100%">Wistar Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">XGTQ herbal extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">189-195</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To evaluate the in-vitro effect of herbal extract recepies, namely XGTQ, in the treatment of liver cirrhosis that induced by Carbon tetrachloride (CCL4) in combination with alcohol and high-fat diet in rats. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Liver cirrhosis was induced by subcutaneously injecting CC14 (initial dose of 5,0ml/kg, followed by 1,2ml/kg twice a week in 10 weeks) in winstar rats. Then, fed with synthetic food, added 20% fat, and 0.05% cholesterol and iron oxalate. Rats were administered a day with fresh water and water mixed with 30% ethanol in another day. The rats were randomly divided into 5 groups and given distilled water (group 1 or control group and group 2 or cirrhosis group), silymarin (group 3 or reference group) or the herbal recipes, aka XGTQ, drug extract (group 4, 5) for 4 weeks. Blood was collected for biochemical test and livers were dissected to evaluate weight, morphology and quantified 4-hydroxyproline to evaluate fibrosis and collagen accumulation.&lt;strong&gt; Results: &lt;/strong&gt;In cirrhotic wistar rats, the XGTQ herbal drug at 19.6 g/kg/24h and 58.8 g/kg/24h showed the ability of reducing the level of enzymes AST, ALT in the blood (p&amp;lt;0.01), increasing plasma albumin and decreasing prothrobin time (p&amp;lt;0.05); improving physical condition, macroscopic and microscopic images of H&amp;amp;E-stained liver; decreasing the concentration of hydroxyproline in the liver and reducing the level of cirrhosis on the masson-stained templates. The effect of herbal recipes XGTQ increased dramatically with the dose, and was equivalent to silymarin at the dose of 70 mg/kg/24h. &lt;strong&gt;Conclusion: &lt;/strong&gt;The aqueous extract of XGTQ herbal remedy has have a good effect in treatment of liver cirrhosis in in-vitro and to be equivalent to that of silymarin at the dose of 70 mg/kg.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">189</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Thanh Ha Tuan Nguyen&lt;sup&gt;1,2,#&lt;/sup&gt;, Ngan Nguyen Hoang&lt;sup&gt;1,#&lt;/sup&gt;, Xuan Thanh Nguyen&lt;sup&gt;1,2&lt;/sup&gt;, Binh Nhu Do&lt;sup&gt;1,2&lt;/sup&gt;, Son Trinh The&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Vietnam Military Medical University, No.160 Phung Hung st, Phuc La, Ha dong, Ha noi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Military Hospital 103, No.261 Phung Hung st, Phuc La, Ha Dong, Ha Noi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;#&lt;/sup&gt;These authors contributed equally to this work and are co‐first authors&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Senzosenkosi Surprise Mkhize</style></author><author><style face="normal" font="default" size="100%">Mthokozisi Blessing Cedric Simelane</style></author><author><style face="normal" font="default" size="100%">Nothando Lovedale Gasa</style></author><author><style face="normal" font="default" size="100%">Ofentse Jacob Pooe</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluating the Antioxidant and Heavy Metal Content of Pleurotus ostreatus Mushrooms Cultivated using Sugar Cane Agro-Waste</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Heavy metals</style></keyword><keyword><style  face="normal" font="default" size="100%">Mushrooms</style></keyword><keyword><style  face="normal" font="default" size="100%">Pleurotus ostreatus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">844-852</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Pleurotus ostreatus&lt;/em&gt;, is one of the most cultivated mushrooms with great economic and medicinal value that can be easily grown on various bio-waste substrates. However, biosafety evaluations on these mushrooms are rarely conducted. Thus, we sought to evaluate the concentration or presence of Heavy metals in P. ostreatus mushrooms cultivated on agro-bio-waste products. Furthermore, the effect of adding agro wastes on wheat bran (WB) cultivated mushrooms was evaluated. &lt;strong&gt;Methods:&lt;/strong&gt; Mushrooms grown in sugar cane tops and bagasse were supplemented with varying levels of WB. Atomic absorption spectrophotometer was applied to evaluate the concentration of heavy metals in the substrates and within mushrooms. Furthermore, DPPH free radical scavenging activity was used to determine antioxidant activity of mushroom extracts. &lt;strong&gt;Results:&lt;/strong&gt; The transfer factor analysis (TF) showed that mushrooms have an affinity to absorb Zn, Cd, Cu and Cr from all tested substrates during cultivation (TF&amp;gt;1). The addition of WB supplement into substrates resulted into significant increase in mushroom yield. However, the increased addition of WB, inversely affected the DPPH scavenging activity of the&lt;em&gt; P.ostreatus&lt;/em&gt; methanolic extracts. &lt;strong&gt;Conclusion: &lt;/strong&gt;The bioabsorption of heavy metals by &lt;em&gt;P. ostreatus&lt;/em&gt; is depended on the metal type. Based on these findings, mushrooms grown on these agro-waste appear to be safe and potent scavenging ability against free radicals.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">844</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Senzosenkosi Surprise Mkhize&lt;sup&gt;1&lt;/sup&gt;, Mthokozisi Blessing Cedric Simelane&lt;sup&gt;2&lt;/sup&gt;, Nothando Lovedale Gasa&lt;sup&gt;1&lt;/sup&gt;, Ofentse Jacob Pooe&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neeraj Choudhary</style></author><author><style face="normal" font="default" size="100%">Pranav Kumar Prabhakar</style></author><author><style face="normal" font="default" size="100%">Gopal L Khatik</style></author><author><style face="normal" font="default" size="100%">Subba Rao Chamakuri</style></author><author><style face="normal" font="default" size="100%">Devesh Tewari</style></author><author><style face="normal" font="default" size="100%">Ashish Suttee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Acute toxicity, In-vitro, In-vivo Antidiabetic Potential of the Flavonoid Fraction of the plant Chenopodium album L</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chenopodium album</style></keyword><keyword><style  face="normal" font="default" size="100%">Lc-Ms</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">765-779</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The &lt;em&gt;Chenopodium album &lt;/em&gt;L. commonly recognized as Bathua, is widely distributed globally and contains various phytoconstituents that help treat several diseases. However, until now, aerial parts' antidiabetic potential and the plant's acute toxicity at fraction level have never been established. &lt;strong&gt;Objectives: &lt;/strong&gt;To investigate the acute toxicity, the&lt;em&gt; in-vitro&lt;/em&gt;,&lt;em&gt; in-vivo&lt;/em&gt; antidiabetic potential of the plant at fraction level. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The aerial parts of the plant were fractionated into different fractions, i.e., flavonoid fraction (CAFF), tannin fraction (CATF), alkaloid fraction (CAAF), saponin fraction (CASF), and were analyzed for&lt;em&gt; in-vitro &lt;/em&gt;alpha-amylase inhibition assay. The CAFF, CATF, and CAAF were selected based on&lt;em&gt; in-vitro &lt;/em&gt;alpha-amylase inhibition assay results and were further screened for its acute toxicity and&lt;em&gt; in vivo &lt;/em&gt;antidiabetic activity using a high-fat diet and streptozotocin-induced diabetes model. The CAFF was characterized by LC-MS, and a molecular docking study was carried out. &lt;strong&gt;Results:&lt;/strong&gt; The &lt;em&gt;in-vitro &lt;/em&gt;alpha-amylase inhibition assay revealed that CAFF was found to be more potent than standard Acarbose having IC&lt;sub&gt;50&lt;/sub&gt; values 122.18 ± 1.15 and 812.83± 1.07 μg/ml, respectively. The CAFF fraction was found to possess potent antidiabetic activity in a dose-dependent manner in both in vitro and &lt;em&gt;in vivo &lt;/em&gt;diabetic models and did not produce any sign of severe toxicity. Furthermore, the bioactive CAFF fraction was characterized by LC-MS, showed the presence of quercetin 3-O-(2’’,6’’-di-O-rhamnosyl) glucoside (QRG) or quercetin 3-O-(2’’,6’’-di-Orhamnosyl) galactoside (QRGa) and quercetin 3-O-rutinoside (rutin) (QR). It is predicted from the molecular docking study that the CAFF fraction primarily acts as an alphaamylase inhibitor. &lt;strong&gt;Conclusion:&lt;/strong&gt; The CAFF fraction was found to poses dose-dependent potent antidiabetic activity and did not produce any sign of severe toxicity and primarily act as an alpha-amylase inhibitor.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">765</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Neeraj Choudhary&lt;sup&gt;1,2&lt;/sup&gt;, Pranav Kumar Prabhakar&lt;sup&gt;1&lt;/sup&gt;, Gopal L. Khatik&lt;sup&gt;1&lt;/sup&gt;, Subba Rao Chamakuri&lt;sup&gt;1&lt;/sup&gt;, Devesh Tewari&lt;sup&gt;1&lt;/sup&gt;, Ashish Suttee&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmaceutical Sciences, Lovely Professional University, Punjab, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana, Punjab, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kiran Giri</style></author><author><style face="normal" font="default" size="100%">Aradhana Singh</style></author><author><style face="normal" font="default" size="100%">Kamlesh M. Palandurkar</style></author><author><style face="normal" font="default" size="100%">Tuhina Banerjee</style></author><author><style face="normal" font="default" size="100%">Satish Chaurasia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antihelmintic Activity of Indigenous Plants Found in India Including Butea Monosperma, Origanum Majorana, Piper Longum and Embelia Ribes And GC-MS Phytochemical Analysis of Plant Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antihelmintic</style></keyword><keyword><style  face="normal" font="default" size="100%">Butea monosperma</style></keyword><keyword><style  face="normal" font="default" size="100%">Embelia ribes</style></keyword><keyword><style  face="normal" font="default" size="100%">Origanum majorana</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1464-1471</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Antimicrobial agents are an essential tool in reducing the burden of the infectious diseases. This study aimed to comprehensively determine the antihelmintic activity of indigenous plants found in India including Butea monosperma, Origanum majorana, Piper longum and Embelia ribes. &lt;strong&gt;Methodology&lt;/strong&gt;&lt;em&gt;:&lt;/em&gt; Additionally, the profiling of the phytochemical composition of the extracts was done. The preparation of the extract was done using Maceration method. For determination of antihelmintic activity Eisenia fetida were used. The gas chromatography-mass analysis was carried out in GCMS-QP-2010 plus system).&lt;strong&gt; Result and conclusion: &lt;/strong&gt;Aqueous extracts of Embelia ribes and Origanum majorana did not show anthelmintic activity at any of the tested concentrations. Aqueous extract of Butea monosperma showed antihelmintic activity at 20 mg/ml and 10 mg/ml at 1 hour and 2-hour time interval respectively. The aqueous extract of Piper longum showed activity at concentration 20mg/ml and 10 mg/ml at the time interval of 1 hour and 3-hour respectively.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1464</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kiran Giri&lt;sup&gt;1,*&lt;/sup&gt;, Aradhana Singh&lt;sup&gt;2&lt;/sup&gt;, Kamlesh M. Palandurkar&lt;sup&gt;3&lt;/sup&gt;, Tuhina Banerjee&lt;sup&gt;2&lt;/sup&gt;, Satish Chaurasia&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221004, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Microbiology, Institute of Medical Science, Banaras Hindu University, Varanasi, 221004, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221004, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221004, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tanuj Joshi</style></author><author><style face="normal" font="default" size="100%">Vijay Juyal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antioxidant Activity of Some Medicinal Plants and their Combination</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Reducing power</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">596-599</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Oxidative Stress leads to several complications within the human body. It is the reason behind the generation of several diseases. Free radicals if generated in excess amount can damage the body to a great extent. Finding newer and potent medicinal plants that can fight oxidative stress can be useful in combating the harmful effects of free radicals. &lt;strong&gt;Methods:&lt;/strong&gt; In the current study ethanolic extract of &lt;em&gt;Ocimum kilimandscharicum&lt;/em&gt;,&lt;em&gt; Thymus serpyllum, Spilanthes acmella&lt;/em&gt; and their combination in equal ratio were used for their ability to counter oxidative stress. The plants were collected from the district of Pithoragarh, Uttarakhand and extracted by soxhlet’s apparataus using absolute ethanol (99.9%). The extracts were then dried and used for the study. &lt;strong&gt;Result:&lt;/strong&gt; It was seen that highest absorbance was shown by ascorbic acid at the lowest as well as the highest concentration in the reducing power assay. Also, the combination of the extracts showed the highest absorbance among all the extracts at both the lowest and highest concentration.&lt;strong&gt; Conclusion: &lt;/strong&gt;A higher absorbance indicates a better antioxidant potential. The best effect was shown by the combined extract among all the extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">596</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tanuj Joshi*, Vijay Juyal&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmaceutical Sciences, Bhimtal, Pin: 263136, Kumaun University (Nainital), INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Binawati Ginting</style></author><author><style face="normal" font="default" size="100%">Mustanir</style></author><author><style face="normal" font="default" size="100%">Nurdin</style></author><author><style face="normal" font="default" size="100%">Maulidna</style></author><author><style face="normal" font="default" size="100%">Murniana</style></author><author><style face="normal" font="default" size="100%">Safrina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antioxidant and Anticancer Activity of Myristica fragrans Houtt. Bark</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Bark</style></keyword><keyword><style  face="normal" font="default" size="100%">n-hexane extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Nutmeg (Myristica fragrans Houtt)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">780-786</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aims to evaluate the antioxidant and anticancer activity of secondary metabolite compounds from &lt;em&gt;Myristica fragrans&lt;/em&gt; Houtt. (nutmeg) bark using n-hexane extract based on DPPH radical scavenging and microculture tetrazolium salt (MTT) assay. The chemical structural analysis using NMR, FTIR, and LC-MS spectroscopy confirmed and identified the structure of isolated compound namely (2E)-5(2z.4E)-hexa-2,4,-dio-zyl)-2propylcyclohexanol (C&lt;sub&gt;18&lt;/sub&gt;H&lt;sub&gt;30&lt;/sub&gt;O&lt;sub&gt;4&lt;/sub&gt;) for the first time which is corresponding for the excellent antioxidant and anticancer activity against MCF-7 cell lines with the IC&lt;sub&gt;50&lt;/sub&gt; value of 99.76 and 10.75 ppm, respectively.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">780</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Binawati Ginting&lt;sup&gt;1,&lt;/sup&gt;*, Mustanir&lt;sup&gt;1&lt;/sup&gt;, Nurdin&lt;sup&gt;1&lt;/sup&gt;, Maulidna&lt;sup&gt;2&lt;/sup&gt;, Murniana&lt;sup&gt;1&lt;/sup&gt;, Safrina&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Politeknik Teknologi Kimia Industri, Medan, 20228, INDONESIA. 3Academy of Pharmacy and Food Analysis, Banda Aceh, 23241, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zahriah</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Co-administration of Roselle Water Extract (Hibiscus sabdariffa L.) and Aspirin for Antiplatelet Therapy in Male Sprague-Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aspirin</style></keyword><keyword><style  face="normal" font="default" size="100%">Bleeding time</style></keyword><keyword><style  face="normal" font="default" size="100%">Roselle water extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Survival rate</style></keyword><keyword><style  face="normal" font="default" size="100%">Thromboembolism</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">563-569</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Various herbal side effects caused by interactions between herbs and drugs have been reported and reviewed. For instance, roselle water extract and aspirin have similar functions in maintaining cardiovascular function. &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to investigate the effect of roselle water extract on aspirin pharmacodynamics observed through the parameters of bleeding time, survival rate and the number of microthrombus that induced thromboembolism in rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Male Sprague-Dawley rats were divided into two different experimental group for bleeding time and survival rate assay. Roselle water extract was given in three various doses (12.5 mg, 25 mg, 50 mg/200 g BW) for seven days followed by aspirin on the last treatment.&lt;strong&gt; Results:&lt;/strong&gt; Results showed that the co-administration of roselle water extract and aspirin did not cause significant changes in the increase in bleeding time, the number of animals that survived and the number of microthrombus. &lt;strong&gt;Conclusion:&lt;/strong&gt; Therefore, roselle water extract does not affect the pharmacodynamics of aspirin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">563</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Zahriah&lt;sup&gt;1,2,&lt;/sup&gt; Fadlina Chany Saputri&lt;sup&gt;3,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Program, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacy Program, Politeknik Kesehatan Kementerian Kesehatan Pangkalpinang, 33684, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MI Bunu</style></author><author><style face="normal" font="default" size="100%">M I Ikhile</style></author><author><style face="normal" font="default" size="100%">AN Matheri</style></author><author><style face="normal" font="default" size="100%">MT Charlotte</style></author><author><style face="normal" font="default" size="100%">MCD Fotsing</style></author><author><style face="normal" font="default" size="100%">DT Ndinteh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Secondary Metabolites, Antibacterial, Antiplasmodial and Acute Toxicity Potentials of Chloroform Crude Extract of Boswellia dalzielii Stem Bark</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiplasmodial</style></keyword><keyword><style  face="normal" font="default" size="100%">Boswellia dalzielii</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS RT</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">393-400</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Medicinal plants contain bioactive compounds that have the potentials to cure many human ailments without unnecessary side effects like most of the chemotherapeutic drugs used today. Therefore, the need for phytochemicals in medicinal plants for potentials application in the treatments of these human ailments as alternatives. Drug resistance parasite has rendered most of the drugs used in treating many human diseases ineffective. There is an urgent need and continuous search for new drugs from natural sources because most of the drugs used are either derived from plant or end-product of the natural source. Antibacterial and antiplasmodial activities of &lt;em&gt;Boswellia dalzielii &lt;/em&gt;stem bark chloroform extract against some pathogens and &lt;em&gt;P. bergei&lt;/em&gt; was investigated using the serial dilution method. Phytochemical studies (GC-MS RT profiling) revealed the presence of some secondary metabolites. The extract was tested against thirteen bacterial strains (&lt;em&gt;Styphylococcus epidermidis, Mycobacterium smegmatis, Enterococcus faecalis, Styplococcus aureus, Bacillus subtilis&lt;/em&gt;) and Gram-negative strains &lt;em&gt;Klebsiella aerugninosa, Proteus vulgaris, K. pneumonia, Klebsiella oxytoca,Entrobacter cloacae, Peptostreptococcus asaccharolyticus, Escherichia coli, Proteus mirabilis&lt;/em&gt;). Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC) of the extract showed activities against &lt;em&gt;Mycobacterium smegmatis,Escherichia coli, Klebsiella oxytoca, Klebsiella aerugninosa &lt;/em&gt;and &lt;em&gt;Proteus vulgaris&lt;/em&gt;. The extract demonstrated high safety with LD50 value greater than 5000 mg/kg body weight. The extract shows a high potent of antiplasmodial activities with&lt;em&gt; P. bargie&lt;/em&gt; inhibition of 66.95%. The results demonstrated that &lt;em&gt;Boswelliadalzielii &lt;/em&gt;stem bark extract can be used as a source of cheaper, less toxic novel antibiotic and antimalarial substances for drug development.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">393</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;M.I. Bunu&lt;sup&gt;1&lt;/sup&gt;, M. I.Ikhile&lt;sup&gt;1&lt;/sup&gt;, A.N. Matheri&lt;sup&gt;2&lt;/sup&gt;, M.T. Charlotte&lt;sup&gt;1&lt;/sup&gt;, M.C.D. Fotsing&lt;sup&gt;1&lt;/sup&gt;, D.T. Ndinteh&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemical Science, University of Johannesburg, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of chemical Engineering, University of Johannesburg, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Veronica Nunez-Urquiza</style></author><author><style face="normal" font="default" size="100%">Juana Villeda-Hernandez</style></author><author><style face="normal" font="default" size="100%">Elizur Montiel-Arcos</style></author><author><style face="normal" font="default" size="100%">Isaac Tello</style></author><author><style face="normal" font="default" size="100%">Victoria Campos-Pena</style></author><author><style face="normal" font="default" size="100%">Maribel Herrera-Ruiz</style></author><author><style face="normal" font="default" size="100%">María del Carmen Gutiérrez</style></author><author><style face="normal" font="default" size="100%">Vera Petricevich</style></author><author><style face="normal" font="default" size="100%">María Angélica Santana</style></author><author><style face="normal" font="default" size="100%">Martha Navarro</style></author><author><style face="normal" font="default" size="100%">Angélica Berenice Aguilar-Guadarrama</style></author><author><style face="normal" font="default" size="100%">Gabriel Navarrete-Vázquez</style></author><author><style face="normal" font="default" size="100%">Irene Perea-Arango</style></author><author><style face="normal" font="default" size="100%">Ismael Leon-Rivera</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the Anticonvulsant, Anxiolytic, Sedative, and Neuroprotective Activities of Polysaccharides from Mycelium of Two Ganoderma Species</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">a- and b-glucan</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticonvulsant</style></keyword><keyword><style  face="normal" font="default" size="100%">GABA</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma curtissi</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma sp</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1161-1173</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Ganoderma lucidum&lt;/em&gt; has been used as a medicinal mushroom since centuries in East Asia. Recent reports have shown that metabolites isolated from &lt;em&gt;Ganoderma&lt;/em&gt; species have shown effects on central nervous system. &lt;strong&gt;Objective:&amp;nbsp;&lt;/strong&gt;To determine the neuroprotective, anticonvulsant, anxiolytic, and sedative effects of &lt;em&gt;Ganoderma &lt;/em&gt;sp. and &lt;em&gt;Ganoderma curtisii&lt;/em&gt; polysaccharides. &lt;strong&gt;Methods:&lt;/strong&gt; Polysaccharides (Gsp-PS2 or Gc-PS2) were isolated from two &lt;em&gt;Ganoderma mycelia&lt;/em&gt; submerged cultures. Acute toxicity effects of Gc-PS2 or Gsp-PS2 on mice were treated orally with doses of 50 - 2000 mg/kg. Anticonvulsant activity was determined using three chemoconvulsants: kainic acid (KA), strychnine, or pentylenetetrazole (PTZ). Anxiolytic-like effects were determined using the elevated plus maze test on mice. GABA release evoked by GC-PS2 or Gsp-PS2 content was determined by HPLC. Neuroprotective effects of Gsp-PS2 or Gc-PS2 were determined by glial activation, histopathological changes, and immunohistochemistry. &lt;strong&gt;Results:&lt;/strong&gt; Gc-PS2 or Gsp-PS2 showed neuroprotective activity by diminishing neuronal death, reducing glial activation and Neu-N expression levels. Gsp-PS2 or Gc-PS2 inhibited convulsions in the KA model. An anxiolytic-like, but not a sedative effect was reported in mice treated with Gc-PS2 or Gsp-PS2. Polysaccharides Gc-PS2 or Gsp-PS2 evoked endogenous GABA release and increased its concentration within the incubation medium. Pretreatment with Gsp-PS2 or Gc-PS2 showed a reduction of the LPSinduced NO production. Gc-PS2 or Gsp-PS2 did not produce toxic effects. &lt;strong&gt;Conclusion:&amp;nbsp;&lt;/strong&gt;&lt;em&gt;Ganoderma &lt;/em&gt;sp. or &lt;em&gt;Ganoderma curtisii &lt;/em&gt;polysaccharides showed neuroprotective and anticonvulsant activities in animal models. The anticonvulsant activity may involve the GABAergic neurotransmision.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1161</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Verónica Núñez-Urquiza,&lt;sup&gt;1&lt;/sup&gt; Juana Villeda- Hernández,&lt;sup&gt;2&lt;/sup&gt; Elizur Montiel-Arcos,&lt;sup&gt;3&lt;/sup&gt; Isaac Tello,&lt;sup&gt;3&lt;/sup&gt; Victoria Campos-Peña,&lt;sup&gt;2&lt;/sup&gt; Maribel Herrera-Ruiz,&lt;sup&gt;4&lt;/sup&gt; María del Carmen Gutiérrez,&lt;sup&gt;5&lt;/sup&gt; Vera Petricevich,&lt;sup&gt;6&lt;/sup&gt; María Angélica Santana,&lt;sup&gt;7&lt;/sup&gt; Martha Navarro,&lt;sup&gt;2&lt;/sup&gt; Angélica Berenice Aguilar-Guadarrama,&lt;sup&gt;1&lt;/sup&gt; Gabriel Navarrete-Vázquez,&lt;sup&gt;8&lt;/sup&gt; Irene Perea- Arango,&lt;sup&gt;5&lt;/sup&gt; Ismael León-Rivera&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Avenida Insurgentes Sur No. 3877 Col. La Fama Tlalpan, Ciudad de México, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina 1, Col. Centro, Xochitepec, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Centro de Investigación en Biotecnología, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Centro de Investigación en Dinámica Celular, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dadang Juanda</style></author><author><style face="normal" font="default" size="100%">Irda Fidrianny</style></author><author><style face="normal" font="default" size="100%">Komar Ruslan Wirasutisna</style></author><author><style face="normal" font="default" size="100%">Muhamad Insanu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Xanthine Oxidase Inhibitory and Antioxidant Activities of Three Organs of Idat (Cratoxylum glaucum Korth.) and Correlation with Phytochemical Cont</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cratoxylum glaucum</style></keyword><keyword><style  face="normal" font="default" size="100%">Xanthine oxidase inhibitory</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">971-976</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Idat (&lt;em&gt;Cratoxylum glaucum &lt;/em&gt;Korth.), belonging to the genus Cratoxylum, is known to contain xanthone, quinone, flavonoids, and other phenolic compounds. &lt;strong&gt;Objectives:&lt;/strong&gt; to analyze total phenolic, flavonoid, antioxidant activity, and inhibitory xanthine oxidase activities of leaves, stem, and cortex of idat. &lt;strong&gt;Methods: &lt;/strong&gt;Extraction of leaves, stem, and cortex of idat was carried out by reflux using n-hexane, ethyl acetate, and ethanol as a solvent. Antioxidant activity was tested by the DPPH method and calculated to get the antioxidant activity index (AAI). Determination of total phenolic and flavonoid levels by ultraviolet-visible spectrophotometry.&lt;strong&gt; Results:&lt;/strong&gt; Spectrophotometers measured the inhibitory activity on xanthine oxidase in 96-well plates with allopurinol as standard. Total phenolic and flavonoid content from &lt;em&gt;C. glaucum&lt;/em&gt; extracts varied from 6.62 to 48.77 g GAE/g extract and 1.54 - 25.96 g QE/100 g extract, respectively. The ethanol extracts of leaves, stem, and cortex were very strong antioxidant activity with Antioxidant Activity Index (AAI) values 3.89; 4.55; 10.50, meanwhile AAI of ascorbic acid and quercetin 9.46 and 14.81 respectively. The n-hexane of stem extract had a strong xanthine oxidase inhibitory activity with the IC&lt;sub&gt;50&lt;/sub&gt; was 36.64 μg/ml, while allopurinol was 5.02 μg/ml. &lt;strong&gt;Conclusions: &lt;/strong&gt;Total phenolic content contributed to antioxidant activity. Phenolic compounds in leaves extracts led to the xanthine oxidase inhibitory and antioxidant activities. The extract of &lt;em&gt;C. glaucum&lt;/em&gt; was active as an antioxidant and potentially an inhibitor of xanthine oxidase agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">971</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dadang Juanda&lt;sup&gt;1,2&lt;/sup&gt;, Irda Fidrianny&lt;sup&gt;1&lt;/sup&gt;, Komar Ruslan Wirasutisna&lt;sup&gt;1&lt;/sup&gt;, Muhamad Insanu&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology, Bandung, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Bhakti Kencana University, Bandung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Asmaa Sayed Abd Elkarim</style></author><author><style face="normal" font="default" size="100%">Amal H. Ahmed</style></author><author><style face="normal" font="default" size="100%">Abdelbaset M. Elgamal</style></author><author><style face="normal" font="default" size="100%">Radwan El Haggar</style></author><author><style face="normal" font="default" size="100%">Alaa Khedr</style></author><author><style face="normal" font="default" size="100%">Mohamed Fouad Shalaby</style></author><author><style face="normal" font="default" size="100%">Roula Bayram</style></author><author><style face="normal" font="default" size="100%">Samah Shabana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evidence Based Evaluation of Pharmacological Activity and Herb-Herb interaction of Organic Extracts of Certain Natural Anti- Diabetic Mixtures</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diabetic herbs</style></keyword><keyword><style  face="normal" font="default" size="100%">Herb-herb interaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal Plants.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1366-1376</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This work aims to find a new treatment based on the development of safe natural anti-diabetic mixtures. It assesses the hypoglycemic activity of natural mixtures and determines whether there are any negative side effects from the interaction of the herbs and the herbs. &lt;strong&gt;Methods:&lt;/strong&gt; Six natural mixtures were tested for anti-diabetic activity, which was confirmed by a pathological histological examination. We performed a GC-MS analysis on active mixtures 1 and 2, yielding 54 and 38 compounds, respectively. The major compounds were Gingerol, Butan-2-one and 4-(3-hydroxy-2-methoxyphenyl) (97 and 64.02 per cent). &lt;strong&gt;Results: &lt;/strong&gt;Among the six samples, the organic extract of mixture 1 and 2 showed a significant reduction in BGL compared to the standard drug glimepiride at a dose of 10 mg/kg ip and demonstrated a beneficial effect on renal function in alloxan-induced diabetic mice. These results were confirmed by a histopathological study which revealed that both mixture 1 and mixture 2 had decreased morphological and ultrastructural changes in the triggered liver. Docking of cuminaldehyde, Gingerol and α-Copaenin at the active site of human pancreatic enzymes α-amylase and aldol reductase revealed that these compounds had binding affinity at the active site of the enzymes. &lt;strong&gt;Conclusion: &lt;/strong&gt;Our results revealed the anti-diabetic activity of non-polar mixtures consisting of long chain hydrocarbons, oils and non-polar components, thus suggesting that the herbal formulation is safe and effective for the treatment and complication of type 2 diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1366</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Asmaa Sayed Abd Elkarim&lt;sup&gt;1,*&lt;/sup&gt;, Amal H. Ahmed&lt;sup&gt;2,&lt;/sup&gt; Abdelbaset M. Elgamal&lt;sup&gt;3&lt;/sup&gt;, Radwan El Haggar&lt;sup&gt;4&lt;/sup&gt;, Alaa Khedr&lt;sup&gt;5&lt;/sup&gt;, Mohamed Fouad Shalaby&lt;sup&gt;5&lt;/sup&gt;, Roula Bayram&lt;sup&gt;5&lt;/sup&gt;, Samah Shabana&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Chemistry of Tanning Materials and Leather Technology Department, National Research Centre, 33 El Bohouthst. (former EL Tahrirst.)- Dokki-Giza, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy Department, Faculty of Pharmacy, Al-azhar University, 11884 Nasr City, Cairo, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Chemistry of Natural and Microbial Products Department, National Research Centre, 33 El Bohouth st. (former EL Tahrir st.)-Dokki- Giza-EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo 11795, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of pharmacognosy, Faculty of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, MUST, 6th October City, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdelhak Chergui</style></author><author><style face="normal" font="default" size="100%">Latifa El Hafid</style></author><author><style face="normal" font="default" size="100%">El Amine Ajal</style></author><author><style face="normal" font="default" size="100%">Imane Zakariya</style></author><author><style face="normal" font="default" size="100%">Rachid Nejjari</style></author><author><style face="normal" font="default" size="100%">Mohammed Reda Tazi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evolution of Biometric Parameters and Oil Fatty Acid Composition of Argan &quot;Argania spinosa L. Skeels&quot; Fruits from Beni- Snassen (Eastern Region of Morocco) During Ripening</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Argan fruits</style></keyword><keyword><style  face="normal" font="default" size="100%">Beni-Snassen</style></keyword><keyword><style  face="normal" font="default" size="100%">Biometeric parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Fatty Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Ripeness</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">296-308</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Argania spinosa&lt;/em&gt; Skeels is an endemic forest essence of Morocco. The argan of the north-east of Morocco remains a virgin subject of study without enough value given to it. &lt;strong&gt;Objective: &lt;/strong&gt;The aim of this study is to asses the evolution of biometric parameters and fatty acids composition of the argan fruits from Beni-Snassen region during ripening. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;4 fruit shapes harvested over seven months were characterized through the measurement of their biometric parameters (size and weight), and their composition of majority fatty acids. &lt;strong&gt;Results: &lt;/strong&gt;the studied argan tree could be classified into two major groups, namely: early-riped trees with oval or oval-apiculate fruits and late-riped trees with fusiform or spherical fruits. When considering the fruits size and weight, the highest values were recorded on late-ripened fruits, more particularly fusiform shapes. The obtained results showed, on one hand, a significant difference in the unsaturated fatty acids, according to the fruit ripeness stage and shapes, being the later significantly affecting the stearic acid content; and on another hand, it was noted an increase of oleic acid content while linoleic acid decreased. In the maturation stage, the spherical shaped fruits were found to have the highest ratio of unsaturated/saturated fatty acids.&lt;strong&gt; Conclusion:&lt;/strong&gt; The results demonstrated the possibility to predict the kernel’s weight from the fruit’s length. The results also showed the good dietary and nutritional quality of spherical shapes and that the biometric parameters are important criteria for the differentiation of argan tree fruits.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">296</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abdelhak Chergui&lt;sup&gt;1,&lt;/sup&gt;*, Latifa El Hafid&lt;sup&gt;2&lt;/sup&gt;, El Amine Ajal&lt;sup&gt;1&lt;/sup&gt;, Imane Zakariya&lt;sup&gt;1&lt;/sup&gt;, Rachid Nejjari&lt;sup&gt;1&lt;/sup&gt;, Mohammed Reda Tazi&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy, Mohammed V University, Faculty of Medicine and Pharmacy, Av. Mohammed Belarabi El Alaoui, BP 6203- Rabat institut-Rabat, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Improving Agricultural Productivity, Biotechnology &amp;amp; Environment, Mohammed I University, Faculty of Science, Blvd. Mohammed VI, BP 717-Oujda, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Regional Center of professions of Education and Training of the Orient- Oujda, MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elham Akbari</style></author><author><style face="normal" font="default" size="100%">Kawsar Alami</style></author><author><style face="normal" font="default" size="100%">Dawood Hossaini</style></author><author><style face="normal" font="default" size="100%">Mohammad Latif Nazari</style></author><author><style face="normal" font="default" size="100%">Mohammad Hossein Salehi</style></author><author><style face="normal" font="default" size="100%">Meysam Sajjadi</style></author><author><style face="normal" font="default" size="100%">Sayed Yousof Mousavi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Afghan Saffron (Crocus sativus L.) Aqueous Extract on Withdrawal Signs in Morphine-Dependent Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aqueous extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Crocus</style></keyword><keyword><style  face="normal" font="default" size="100%">Morphine dependence</style></keyword><keyword><style  face="normal" font="default" size="100%">Withdrawal signs</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1727-1731</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Opioid dependency, as a global problem is accompanied with serious personal, economic, social and hygienic disorders. Synthetic drugs beside their efficacies, have numerous adverse effects. As the medicinal plants have low costs and adverse effects, and they are also affective on different stages of dependency treatment, they attracted the attention of the researchers in the field of medicine. This study was aimed to investigate the effect of the aqueous extract of Afghan saffron on the withdrawal signs in morphine-dependent rats. &lt;strong&gt;Methods:&lt;/strong&gt; Rats divided into 5 groups (1 Normal Saline, 1 Morphine, and 3 Extract groups). The rats that received morphine and extract became morphine-dependent by subcutaneous (s.c.) administration of morphine hydrochloride for 7 days (2.5, 2.5, 5, 10, 20, 40 mg/kg doses twice daily on 1st to 6th days respectively, and a single dose of 50 mg/kg on 7th day). The extract groups received 100, 150 and 200 mg/kg doses of the saffron aqueous extract by intraperitoneal (i.p.) administration simultaneously with morphine. Two hours after the administration of the last dose of morphine, Naloxone (3 mg/kg, i.p.) was injected and withdrawal signs were noted for 30 minutes. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that the administration of the saffron aqueous extract (100, 150 and 200 mg/kg) significantly decreased most of the withdrawal signs in morphine-dependent rats (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Afghan saffron aqueous extract can alleviate the withdrawal signs in morphine-dependent rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1727</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elham Akbari&lt;sup&gt;1&lt;/sup&gt;, Kawsar Alami&lt;sup&gt;1&lt;/sup&gt;, Dawood Hossaini&lt;sup&gt;1&lt;/sup&gt;, Mohammad Latif Nazari&lt;sup&gt;1&lt;/sup&gt;, Mohammad Hossein Salehi&lt;sup&gt;2&lt;/sup&gt;, Meysam Sajjadi&lt;sup&gt;1&lt;/sup&gt;, Sayed Yousof Mousavi&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research and Technology Center, Khatam Al-Nabieen University, Karte 4, 1st street, Kabul, AFGHANISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Kabul Medical University, Ataturk avenue, Jamal Mena, 3rd District, Kabul, AFGHANISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Physiology, Khatam Al- Nabieen university, Karte 4, 1st street, Kabul, AFGHANISTAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hamida Sadat</style></author><author><style face="normal" font="default" size="100%">Kawsar Alami</style></author><author><style face="normal" font="default" size="100%">Sayed Yousof Mousavi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Afghan Senjed (Elaeagnus Angustifolia L.) Leaves Aqueous alcoholic Extract on Blood Glucose Level of Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Blood glucose level</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetic rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Elaeagnus Angustifolia leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose tolerance</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1218-1222</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Diabetes mellitus is a metabolic disorder, which affects many people throughout the world. The inefficacy and multiple side effects of most synthetic anti-diabetic drugs are reported by various studies. Thus, many researchers are focused on the use of medicinal plants as safe and potent anti-hyperglycemic drugs. The aim of this study is the evaluation of the effect of Afghan senjed (&lt;em&gt;Elaeagnus Angustifolia&lt;/em&gt; L.) leaves aqueous alcoholic extract on blood glucose level of diabetic rats. &lt;strong&gt;Methods: &lt;/strong&gt;Rats were divided into 6 groups: normal, diabetic, metformin and &lt;em&gt;Elaeagnus Angustifolia&lt;/em&gt; leaves extract (EALE) groups, which received 200, 400 and 800 mg/kg doses of extract for 15 days. Diabetes was induced by single dose intraperitoneal administration of streptozotocin (STZ). During treatment, the effect of single and repeated oral administration of EALE on blood glucose level of diabetic rats was evaluated. On last day, the effect of EALE on oral glucose tolerance test (OGTT) was also assessed. &lt;strong&gt;Results: &lt;/strong&gt;All doses of EALE showed significant reduction in blood glucose level, an improvement of glucose tolerance and enhancement in body weight. &lt;strong&gt;Conclusion:&lt;/strong&gt; EALE possessed an antihyperglycemic property in diabetic rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1218</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hamida Sadat&lt;sup&gt;1&lt;/sup&gt;, Kawsar Alami&lt;sup&gt;1&lt;/sup&gt;, Sayed Yousof Mousavi&lt;sup&gt;2,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research and technology center, Khatam Al- Nabieen University, Karte 4, 1&lt;sup&gt;st&lt;/sup&gt; street, Kabul, AFGHANISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of physiology, Khatam Al- Nabieen university, Karte 4, 1&lt;sup&gt;st &lt;/sup&gt;street, Kabul, AFGHANISTAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maissa’ Taleb Shawagfeh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Carthamus tenuis Extracts on the Cell Proliferation of Different Tumor Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Carthamus tenuis</style></keyword><keyword><style  face="normal" font="default" size="100%">IC50</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1332-1339</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Carthamus tenuis&lt;/em&gt; is one of the medicinal plants that was used traditionally to treat skin diseases, hemorrhoids, abortion, infertility. It also showed an immunosuppressive role as well as antifungal, antibacterial, anti-inflammatory activity. Although this plant is widespread, there are few studies about its medical applications. &lt;strong&gt;Objectives: &lt;/strong&gt;This study was done to explore the anticancer activity of this plant. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The aerial parts of the plant were dried, grinded and extracted with hexane, ethyl acetate, and methanol. The extracts were applied in different concentrations to cell cultures of breast (MCF-7), colon (HT-29), prostate (PC-3) and colorectal (CaCo-2) cell lines and fibroblast (MRC- 5) was used as a control. The anticancer activity was evaluated by 3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetrazolium (MTT) reduction assay that was measured by spectrophotometer. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that methanol extract significantly (p&amp;lt;0.05) have the highest inhibitory activity on MCF-7, HT-29, PC-3, and CaCo-2 with IC&lt;sub&gt;50&lt;/sub&gt;; (25.52 μg/ml), (17.37 μg/ml), (25.77 μg/ml), (24.49 μg/ml), respectively. Followed by ethyl acetate extract that moderately inhibit cell growth of PC-3 and CaCo-2 with IC&lt;sub&gt;50&lt;/sub&gt;; (28.99 μg/ml) and (21.45 μg/ml), respectively. n-hexane extract showed no significant inhibitory effect on all cell lines; IC&lt;sub&gt;50&lt;/sub&gt; (125.52 -152.34 μg/ml) when compared to Tamoxifen drug activity as a positive control. &lt;strong&gt;Conclusion: &lt;/strong&gt;Results of this study showed the anticancer activity of the plant extracts in four different kinds of cancers that need further study.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1332</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maissa’ Taleb Shawagfeh* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Medical Allied Sciences, Zarqa University College, Al-Balqa Applied University, JORDAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Buavaroon Srichaikul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Lentinus squarrosulus, (Mont.) Consumption on the Treatment of Gastritis in Male Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Beta glucan</style></keyword><keyword><style  face="normal" font="default" size="100%">L. squarrosulus</style></keyword><keyword><style  face="normal" font="default" size="100%">Ranetidine 150 mg</style></keyword><keyword><style  face="normal" font="default" size="100%">Ulcer healing</style></keyword><keyword><style  face="normal" font="default" size="100%">Ulcer prevention</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1093-1096</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Gastritis or /and gastric ulcers are one of the most common symptoms which occur in a large amount of the population. It results in a very high amount of medication expense. This study investigated the prevention and treatment of gastritis or /and gastric ulcer actions using white log mushroom (&lt;em&gt;Lentinus squarrosulus&lt;/em&gt;, (Mont.). &lt;strong&gt;Methods: &lt;/strong&gt;White wistar rats were induced with 100 % absolute alcohol to be effective for gastritis and /or ulceration within rats. The gastric lesions of white wistar rats were investigated and calculated the lesions of stomach areas under microscopic method. The results were calculated and a comparative study among white wistar rats. Ulcer prevention and ulcer healing properties were administrated though a dose of 250 mg/kg of &lt;em&gt;L. squarrosulus &lt;/em&gt;extract and &lt;em&gt;L. squarrosulus &lt;/em&gt;compared with 50 mg/kg of Ranetidine. &lt;strong&gt;Results: &lt;/strong&gt;It was found that &lt;em&gt;Lentinus squarrosulus&lt;/em&gt;, (Mont.) consisted of Beta-glucan was the active ingredient creating a healing effect. It showed a result of 100% healing effect in gastritis and/or ulcers in which it had similar healing effects between extracted solutions of white log mushroom (250 mg/kg body wt.) The healing activity also showed the equivalent effect compared to Ranetidine 150mg.&lt;strong&gt; Conclusions:&lt;/strong&gt; Extracted solution of white log mushroom showed prevention and treatment efficacy in gastritis and/ or ulcer are equivalent to Ranetidine 150 mg. A similar dose of 250 mg/kg of &lt;em&gt;L. squarrosulus &lt;/em&gt;extract and &lt;em&gt;L. squarrosulus&lt;/em&gt; snack can prevent and heal ulcers and is more effective than Ranetidine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1093</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Buavaroon Srichaikul* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Public Health, Mahasarakham University, Mahasarakham 44150, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Titik Sumarawati</style></author><author><style face="normal" font="default" size="100%">Ignatius Riwanto</style></author><author><style face="normal" font="default" size="100%">Soeharyo Hadisaputro</style></author><author><style face="normal" font="default" size="100%">Edi Dharmana</style></author><author><style face="normal" font="default" size="100%">Taufiqurachman Nasihun</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Phaleria macrocapa on Atrophy and Apoptosis of Intestinal Mucous Cell and Phalerin Concentration at Portal Vein and Systemic Circulation in Adenocarcinoma Mice following Adriamycine and Cyclophosphamide Treatment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Atrophy</style></keyword><keyword><style  face="normal" font="default" size="100%">Concentration</style></keyword><keyword><style  face="normal" font="default" size="100%">Phalerin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">603-610 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Chemotherapy has been proven capable of reducing breast cancer cell progression; however the adverse effect also emerging. Thus, diminish those adverse effects with botanical product &lt;em&gt;Phaleria macrocarpa &lt;/em&gt;(PM) as adjuvant therapy is necessary. &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to evaluate the effect of PM treatment in combination with &lt;em&gt;adriamycine&lt;/em&gt; and cyclophosphamide (AC) on intestinal apoptosis and their correlation with phalerin concentration in systemic circulation. &lt;strong&gt;Methods: &lt;/strong&gt;In the experimental study, 30 female mice with adenocarcinoma were assign into 5 groups: Neg-G, only given aquadest; Portal vein group (PMV-G) and systemic circulation groups (PMC-G), were administered PM 0.146mg/day; Portal vein group (PMACV-G) and systemic circulation group (PMACC-G), were administered &lt;em&gt;Phaleria macrocarpa &lt;/em&gt;0,146 mg orally, &lt;em&gt;Adriamycine &lt;/em&gt;0,013 mg and Cyclophosphamide 0,0156 mg singgle dose intravenously. Phalerin concentration was measured by HPLC methods at minute 30, 60, 90, 120, 150, and 180 after treatment. At the end of study, intestinal mucous cell apoptosis was identified by TUNEL methods. &lt;strong&gt;Results: &lt;/strong&gt;independent t test analyses showed that index of apoptosis of intestinal mucous cell were significant higher in PMAC-G compared to that of Neg-G and PM-G, p &amp;lt; 0.05. In contrary, phalerin concentration in PMAC-G was significant lower compared to that of PM-G, p &amp;lt; 0.05. The Pearson analysis indicated the inverse correlation (r= -736, p&amp;gt;0.05) between apoptosis index with phalerin concentration.&lt;strong&gt; Conclusion: &lt;/strong&gt;Treatment of PM in combination with AC has been proven able to increase intestinal mucous cell apoptosis and decrease phalerin concentration. However, the inverse correlation didnot exist.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">603</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Titik Sumarawati&lt;sup&gt;1,&lt;/sup&gt;*, Ignatius Riwanto&lt;sup&gt;2&lt;/sup&gt;, Soeharyo Hadisaputro&lt;sup&gt;3&lt;/sup&gt;, Edi Dharmana&lt;sup&gt;4&lt;/sup&gt;, Taufiqurachman Nasihun&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry Medical Faculty of Sultan Islamic Agung University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Surgery, Medical Faculty of Diponegoro University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Internal Medicine Medical Faculty of Diponegoro University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Parasitology Medical Faculty of Diponegoro University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry Medical Faculty of Sultan Agung Islamic University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sundarapandian Subramanian</style></author><author><style face="normal" font="default" size="100%">Mohammed Junaid Hussain Dowlath</style></author><author><style face="normal" font="default" size="100%">Sathish Kumar Karuppannan</style></author><author><style face="normal" font="default" size="100%">Saravanan M</style></author><author><style face="normal" font="default" size="100%">Kantha Devi Arunachalam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Solvent on the Phytochemical Extraction and GC-MS Analysis of Gymnema sylvestre</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">Cold maceration</style></keyword><keyword><style  face="normal" font="default" size="100%">Gymnema sylvestre</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">plant constituents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">749-761</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The medicinal plant &lt;em&gt;Gymnema sylvestre&lt;/em&gt; found in the Indian subcontinent and Srilanka is known for its anti-diabetic, diuretic, anti-obesity, anti-cancer, antimicrobial, anti-inflammatory properties. The current study is focused on the phyto compound extraction efficiency of different solvents like ethanol, methanol, ethyl acetate, hexane, benzene and chloroform by gas chromatography–mass spectrometry analysis of &lt;em&gt;Gymenma sylvestre. &lt;/em&gt;From the results, it is concluded that &lt;em&gt;G. sylvestre&lt;/em&gt; leaves extracts contains more than 38 phyto compounds with natural antioxidants potential. Further analysis of the extract will help in identifying the effective compounds which can be of potent use in the pharmacological field.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">749</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sundarapandian Subramanian&lt;sup&gt;1&lt;/sup&gt;, Mohammed Junaid Hussain Dowlath&lt;sup&gt;1&lt;/sup&gt;, Sathish Kumar Karuppannan&lt;sup&gt;1&lt;/sup&gt;, Saravanan M&lt;sup&gt;2&lt;/sup&gt;, Kantha Devi Arunachalam&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Center for Environmental Nuclear Research, Directorate of Research, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammed Junaid Hussain Dowlath</style></author><author><style face="normal" font="default" size="100%">Sathish Kumar Karuppannan</style></author><author><style face="normal" font="default" size="100%">Darul Raiyaan GI</style></author><author><style face="normal" font="default" size="100%">Mohamed Khalith SB</style></author><author><style face="normal" font="default" size="100%">Sundarapandian Subramanian</style></author><author><style face="normal" font="default" size="100%">Kantha Deivi Arunachalam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Solvents on Phytochemical Composition and Antioxidant Activity of Cardiospermum halicacabum (L.) Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cardiospermum halicacabum</style></keyword><keyword><style  face="normal" font="default" size="100%">Cold maceration</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Radical scavenging activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1241-1251</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Cardiospermum halicacabum&lt;/em&gt; (&lt;em&gt;C. halicacabum&lt;/em&gt;) is a common medicinal herb found in India and other Asian countries. It has various medicinal properties such as antimicrobial, pain relief, antibiotics, anti-inflammatory, antioxidants, anticancer etc. It is commonly used for treating diabetes, arthritis, limbs stiffness, rheumatism, lumbago, earache, fever. Type of solvent and polarity intensively affects the antioxidant activity of the extracts due to the solubility of the phytocompounds such as polyphenols and flavonoids in various solvents.&lt;strong&gt; Materials and Methods: &lt;/strong&gt;In this study, different solvents like, ethanol, methanol, chloroform and petroleum ether were used for the extraction of &lt;em&gt;C. halicacabum&lt;/em&gt;. Cold maceration method was followed for extraction. The crude extracts were screened preliminary and then confirmed using Fourier transform-infrared spectroscopy analysis. Gas chromatography-mass spectrometry was used to determine the chemical composition of each extract. The DPPH (2,2-diphenyl- 1-picrylhydrazyl) method was used for the evaluation of the antioxidant activity of different crude extracts of &lt;em&gt;C. halicacabum.&lt;/em&gt; &lt;strong&gt;Results:&lt;/strong&gt; The results showed that there is significant influence of solvent type in preserving various phytocompounds of the &lt;em&gt;C. halicacabum&lt;/em&gt; leaves extract. The evaluation of the antioxidant capacity of different crude extracts was in the order of ethanol &amp;gt; methanol &amp;gt; petroleum ether &amp;gt; chloroform extract.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1241</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mohammed Junaid Hussain Dowlath, Sathish Kumar Karuppannan, Darul Raiyaan GI, Mohamed Khalith SB, Sundarapandian Subramanian and Kantha Deivi Arunachalam*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Center for Environmental Nuclear Research, Directorate of Research, SRM Institute of Science and Technology, Kattankulathur- 603203, India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aditya Sindu Sakti</style></author><author><style face="normal" font="default" size="100%">Astari Rachma Nityasa</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Uncaria gambir and Uncaria sclerophylla on Pulmonary- Thromboembolism Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antithrombotic</style></keyword><keyword><style  face="normal" font="default" size="100%">Bleeding time</style></keyword><keyword><style  face="normal" font="default" size="100%">Pulmonary thromboembolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Survival rate</style></keyword><keyword><style  face="normal" font="default" size="100%">Uncaria gambir</style></keyword><keyword><style  face="normal" font="default" size="100%">Uncaria sclerophylla</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">192-196</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Previous studies on virtual screening on P2Y&lt;sub&gt;12 &lt;/sub&gt;receptor of Adenosine Diphosphate (ADP) have showed that Roxburghine B, the compound which is found in Uncaria species, can inhibit the receptor function. &lt;strong&gt;Objective: &lt;/strong&gt;In this study, we investigated the effect of &lt;em&gt;Uncaria gambir &lt;/em&gt;and &lt;em&gt;Uncaria sclerophylla &lt;/em&gt;extract on survival rate and bleeding time as antithrombotic &lt;em&gt;in vivo&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Animal subjects (ddY strain mice) were divided to two different experimental group (survival rate and bleeding time). &lt;em&gt;U. gambir &lt;/em&gt;and &lt;em&gt;U. sclerophylla&lt;/em&gt; were given to the mice orally in three different dose (5 mg, 10 mg, 20 mg/20 g BW and 2.5 mg, 5 mg, 10 mg/20 g BW, respectively) for seven days. &lt;strong&gt;Results: &lt;/strong&gt;&lt;em&gt;U. gambir&lt;/em&gt; and &lt;em&gt;U. sclerophylla &lt;/em&gt;able to prolong bleeding time from test subjects equivalent to ASA as standard. The results show the increasing number of survived animals in the treated group compared to the negative control group.&lt;strong&gt; Conclussion:&lt;/strong&gt; Both of &lt;em&gt;U. gambir &lt;/em&gt;and &lt;em&gt;U. sclerophylla &lt;/em&gt;prevent pulmonary thromboembolism on mice subjects represent by the increased of survival rate. Antithrombotic effects that were observed suggested was provide by their antiplatelet activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">192</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aditya Sindu Sakti&lt;sup&gt;1&lt;/sup&gt;, Astari Rachma Nityasa&lt;sup&gt;2&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Drug Development Laboratory, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok 16424 West Java INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amjad T Shatarat</style></author><author><style face="normal" font="default" size="100%">Sawsan Abuhamdah</style></author><author><style face="normal" font="default" size="100%">Eman Alefishat</style></author><author><style face="normal" font="default" size="100%">Mohamed K Al-Essa</style></author><author><style face="normal" font="default" size="100%">Rima Altaweel R</style></author><author><style face="normal" font="default" size="100%">Faisal Mohammed</style></author><author><style face="normal" font="default" size="100%">Darwish Badran</style></author><author><style face="normal" font="default" size="100%">Hanan Jafar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Beta-Carboline Alkaloids of Peganum Harmala on Induced Rat Ileum Contractions</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Harmaline</style></keyword><keyword><style  face="normal" font="default" size="100%">Harmalol</style></keyword><keyword><style  face="normal" font="default" size="100%">Harmine</style></keyword><keyword><style  face="normal" font="default" size="100%">Ileum</style></keyword><keyword><style  face="normal" font="default" size="100%">Peganum Hermala L</style></keyword><keyword><style  face="normal" font="default" size="100%">Rat</style></keyword><keyword><style  face="normal" font="default" size="100%">Spasmolytic</style></keyword><keyword><style  face="normal" font="default" size="100%">β-Carbolines alkaloids</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">260-265</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Peganum harmala &lt;/em&gt;L., Zygophyllaceae popularly known as Wild Syrian rue, a well-known plant in folk medicine for many pharmacological uses including antispasmodic activity. Chemical composition of the plant showed that the most important constituents of this plant are betacarboline alkaloids such as harmalol, harmaline, and harmine. In this work, we aimed to evaluate the effects of these three major harmala alkaloids on induced rat ileum contractions, induced by acetylcholine, BaCl&lt;sub&gt;2&lt;/sub&gt; and KCl. Of these three harmala alkaloids, harmalol and harmaline produced a concentration-dependent spasmolytic activity, which was found to be reversible (i.e. disappeared after tissue wash-up. Both alkaloids inhibited acetylcholine and KCl-induced ileum contractions but BaCl&lt;sub&gt;2&lt;/sub&gt; -induced contractions were only inhibited by harmalol but not harmaline. Harmine did not show any inhibitory activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">260</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amjad T. Shatarat&lt;sup&gt;1,&lt;/sup&gt;*, Sawsan Abuhamdah&lt;sup&gt;2,3&lt;/sup&gt;, Eman Alefishat&lt;sup&gt;3,4&lt;/sup&gt;, Mohamed Al-Essa&lt;sup&gt;5&lt;/sup&gt;, Rima Altaweel R&lt;sup&gt;1&lt;/sup&gt;, Faisal Mohammed&lt;sup&gt;5&lt;/sup&gt;, Darwish Badran&lt;sup&gt;1&lt;/sup&gt;, Hanan Jafar&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomy and Histology, School of Medicine, The University of Jordan, Amman, JORDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;College of Pharmacy, Al-Ain University, Abu Dhabi, UAE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman, JORDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, College of Medicine and Health Sciences, Khalifa University, UAE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Physiology and Biochemistry, School of Medicine, The University of Jordan, JORDAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nita Sari Wijaya</style></author><author><style face="normal" font="default" size="100%">Katrin Basah</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Pearl Grass Extract Capsules on Osteoarthritis Subject</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Clinical efficacy</style></keyword><keyword><style  face="normal" font="default" size="100%">Pearl grass extract capsules</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword><keyword><style  face="normal" font="default" size="100%">VAS scale</style></keyword><keyword><style  face="normal" font="default" size="100%">WOMAC scale</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">303-310</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Pearl grass extract, a standardized bioactive polar extract of the herbs of Hedyotis corymbosa, is preclinically proven to have an activity to osteoarthritis and rheumatoid arthritis properties in an animal model. The current clinical study has evaluated the efficacy and safety of Pearl grass extract of osteoarthritis subjects. This research was a pilot study of osteoarthritis subjects using Parallel double-blind study design. Subjects have normal renal and liver function, above 50 years of age, and has a sign and symptoms of osteoarthritis included in the study. In the treatment, Pearl grass capsules were given as one capsule once daily for eight weeks, throughout the study, the weekly assessment to evaluate the adverse event. Thirty subjects of mean age 55.90 ± 3.7 years were evaluable. Pearl grass extract capsules did not change renal and liver function in 56 days treatment. Pearl grass capsule markedly reduced the consumption of analgesic drug compared with placebo groups. Pearl grass capsules also decreased pain scale better compare with placebo.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">303</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nita Sari Wijaya&lt;sup&gt;1&lt;/sup&gt;, Katrin Basah&lt;sup&gt;2&lt;/sup&gt;, Anton Bahtiar&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bayyinatul Muchtaromah</style></author><author><style face="normal" font="default" size="100%">Roihatul Muti’ah</style></author><author><style face="normal" font="default" size="100%">Desy Rahma Yusmalasari</style></author><author><style face="normal" font="default" size="100%">Putri Mardyana</style></author><author><style face="normal" font="default" size="100%">Tanjina Sharmin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy of Allium sativum, Curcuma mangga and Acorus calamus Extract Combination on Rat Fertility</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acorus calamus</style></keyword><keyword><style  face="normal" font="default" size="100%">Allium sativum</style></keyword><keyword><style  face="normal" font="default" size="100%">Curcuma mangga</style></keyword><keyword><style  face="normal" font="default" size="100%">Fertility</style></keyword><keyword><style  face="normal" font="default" size="100%">Rat</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">197-203</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; to evaluate the efficacy of &lt;em&gt;Allium sativum&lt;/em&gt;, &lt;em&gt;Curcuma mangga&lt;/em&gt;, and&lt;em&gt; Acorus calamus&lt;/em&gt; extract combination on female rat fertility. &lt;strong&gt;Methods:&lt;/strong&gt; Thirty-six female rats were randomized divided into 9 groups (&lt;em&gt;n&lt;/em&gt;=4): C- (no treatment); C+ (clomiphene citrate); composition 1 (A. sativum 36%: &lt;em&gt;C. mangga&lt;/em&gt; 36%: &lt;em&gt;A. calamus&lt;/em&gt; 28%) with 3 doses i.e T1, T2 &amp;amp; T3 of 50, 75 &amp;amp; 100 mg/kg BW; composition 2 (A. sativum 35%:&lt;em&gt; C. mangga &lt;/em&gt;40%: &lt;em&gt;A. calamus &lt;/em&gt;25%) with 3 doses i.e T4, T5 &amp;amp; T6 of 50, 75 &amp;amp; 100 mg/kg BW and T7 (Subur Kandungan herb™). Treatment was given every day for 15 days. &lt;strong&gt;Results:&lt;/strong&gt; The results revealed that all treatments affected reproductive hormone and uterine histology profile. However, T1 produced the highest estrogen and progesterone levels, and T2 produced the highest endometrial and myometrium thickness, as well as the number of endometrial glands. Furthermore, the hormonal profile in T1 and histological profile of uterus in T2 were not significantly different from those of T7 group. &lt;strong&gt;Conclusions: &lt;/strong&gt;&lt;em&gt;Combined A. sativum, C. mangga, &lt;/em&gt;and &lt;em&gt;A. calamus&lt;/em&gt; extracts could be used to increase fertility in female rat. The most effective treatment in this study was dose of 50-75 mg/BW in both compositions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">197</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bayyinatul Muchtaromah&lt;sup&gt;1,&lt;/sup&gt;*, Roihatul Muti’ah&lt;sup&gt;2&lt;/sup&gt;, Desy Rahma Yusmalasari&lt;sup&gt;1&lt;/sup&gt;, Putri Mardyana&lt;sup&gt;1&lt;/sup&gt;, Tanjina Sharmin&lt;sup&gt;3&lt;/sup&gt;, Amaq Fadholly&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Islam Negeri (UIN) Maulana Malik Ibrahim Malang, Malang 65144, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine and Health Sciences, Universitas Islam Negeri (UIN) Maulana Malik Ibrahim Malang, Malang 65144, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemical Engineering, Faculty of Engineering, Fukuoka University, JAPAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Doctoral Student of Veterinary Science Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">N Srinivasan</style></author><author><style face="normal" font="default" size="100%">S Dhanalakshmi</style></author><author><style face="normal" font="default" size="100%">P Pandian</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Encouraging Leads from Marine Sources for Cancer Therapy A Review Approach</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Algae</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-cancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Marine sponges</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural sources</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1475-1481</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Cancer is one of the dreadful illnesses that cause mortality in many individuals around the world. Present cancer treatments generally include surgery, radiation therapy with chemotherapy. One of the primary sources of anticancer drugs are natural products that exhibit impressive potential in medicines. Plant and microbial secondary metabolites are an important source for cancer drug development. The ocean has an immense collection of flora and fauna overflowing with natural compounds having potent pharmaceutical significance. Marine bioprospecting has just started recently hence, marine ecosystem has not yet been explored properly. Nearly 68 percent of the drugs derived from marine sources are utilized for cancer and the remaining are utilized for inflammation, pain relief etc. Ongoing advancement in synthetic processes has helped in solving the limitations caused due to the complicated structure of natural products. Unlimited potent sources of compounds that can be isolated having diverse structures are found in the marine biodiversity. Only 1% of the marine microorganisms have been distinguished till now. Coral reefs and mangrove ecosystem have been focused for bioprospecting on the grounds that they have an elevated level of biodiversity. This review focuses on pharmacologically active anti-cancer lead discovery from marine ecosystem. The review has also tried to describe the structure&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1475</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;N. Srinivasan&lt;sup&gt;1,&lt;/sup&gt;*, S.Dhanalakshmi&lt;sup&gt;2&lt;/sup&gt;, P.Pandian&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram – 608002, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Dr.M.G.R Educational and Research Institute (Deemed to be University), Chennai - 600 077, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vijay Danapur</style></author><author><style face="normal" font="default" size="100%">Haleshi C</style></author><author><style face="normal" font="default" size="100%">Sringeswara AN</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Endangered Medicinal Plant Coscinium fenestratum (Gaertn.) Colebr A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Berberine Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Coscinium fenestratum Menispermaceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1077-1085</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Coscinium fenestratum&lt;/em&gt; (Gaertn.) Colebr. (Menispermaceae), is a large woody liana found in moist deciduous to the evergreen forest at an altitude of 350-1200m. It is well suited to wet evergreen, semi evergreen, deciduous and dry deciduous forest types. Stem and root of this species are highly medicinal and is sold in the drug sales of India as Maramanjal and Europe as False Calumba or tree turmeric. The stem is bitter, anti-inflammatory, antiseptic, febrifuge and tonic and is useful in vitiated conditions of kapha and vata, ophthalmopathy, wounds, ulcers, diabetes, fever, and general debility. Due to destructive collection, overexploitation and habitat loss, the plant is on the verge of extinction in the wild. It is categorized as critically endangered in India, Vulnerable in Vietnam, and Indeterminate in Sri Lanka and Malaysia1-47. Therefore an overview of this plant on pharmacognosy, pharmacology, safety and toxicity is presented below along with HPLC details of Berberine the active ingredient in the stem and root of the plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1077</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vijay Danapur*, Haleshi C, Sringeswara AN &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Vriksha Vijnan Private Limited, #520, Brundavana, 10th Main, 3rd Cross, BHCS Layout, Chikkallasandra, Bangalore-560061, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Charles Lalnunfela</style></author><author><style face="normal" font="default" size="100%">PB Lalthanpuii</style></author><author><style face="normal" font="default" size="100%">TC Lalhriatpuii</style></author><author><style face="normal" font="default" size="100%">K Lalchhandama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An Endangered Medicinal Plant, Ilex khasiana Exhibits Potent Antiparasitic Activity Against Intestinal Tapeworm</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Parasite</style></keyword><keyword><style  face="normal" font="default" size="100%">Scanning electron microscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Tapeworm</style></keyword><keyword><style  face="normal" font="default" size="100%">Tegument</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">725-730</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;A species of holly, &lt;em&gt;Ilex khasiana &lt;/em&gt;Purk. (family Aquifoliaceae) is one of a few critically endangered medicinal plants in India. It is endemic to Khasi Hills, Meghalaya, and Aizawl, Mizoram. In the traditional medicines of Khasi and Mizo people, the leaves are used as a panacea for all sorts of infections. Nothing is known about its true pharmacological potentials. &lt;strong&gt;Objective:&lt;/strong&gt; We aimed to assess the extract of &lt;em&gt;I. khasiana &lt;/em&gt;leaves for its purported antiparasitic property. To test the antiparasitic activity, we collected intestinal tapeworms, &lt;em&gt;Raillietina tetragona.&lt;/em&gt; &lt;strong&gt;Materials and Methods:&lt;/strong&gt; &lt;em&gt;I. khasiana &lt;/em&gt;leaves were dried and extracted in methanol. The plant extract was used to treat the tapeworms at different concentrations. The efficacy was recorded as survival values and were analysed by Student’s t-test. The plant extracttreated tapeworms were fixed, dehydrated and observed under scanning electron microscopy for studying the structural details. &lt;strong&gt;Results: &lt;/strong&gt;The methanol extract of&lt;em&gt; I. khasiana&lt;/em&gt; leaf showed dose-dependent antiparasitic effect as that of albendazole. The treated tapeworms developed massive structural damages. The scolex was deformed, with its tegument extensively damaged. The suckers had their spines clumped. The body segments severely contracted and some portions were eroded. Hair-like microtriches were completely lost. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our findings indicate that &lt;em&gt;I. khasiana&lt;/em&gt; has antiparasitic activity and requires further investigations, and that there is a need to foster its conservation and propagation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">725</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Charles Lalnunfela&lt;sup&gt;1,2&lt;/sup&gt;, P. B. Lalthanpuii&lt;sup&gt;2&lt;/sup&gt;, T. C. Lalhriatpuii&lt;sup&gt;1&lt;/sup&gt;, K. Lalchhandama&lt;sup&gt;2,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Zemabawk 796017, Mizoram, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Life Sciences, Pachhunga University College, Aizawl 796001, Mizoram, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ratika Rahmasari</style></author><author><style face="normal" font="default" size="100%">Takahiro Haruyama</style></author><author><style face="normal" font="default" size="100%">Muhareva Raekiansyah</style></author><author><style face="normal" font="default" size="100%">Farhana Mossadeque</style></author><author><style face="normal" font="default" size="100%">Marina Ika Irianti</style></author><author><style face="normal" font="default" size="100%">Ayun Erwina Arifianti</style></author><author><style face="normal" font="default" size="100%">Nobuyuki Kobayashi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Establishment of Simple Cell-based Screening Assay and the Identification of Potent Antiviral Activity of a Plant Extract against HSV-1</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HSV-1</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural product activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Simple cell-based screening</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">251-259</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Backgrounds: &lt;/strong&gt;Drug screening is a time-consuming and costly process confronted with low productivity and challenges in using animals, which limits the discovery of new drugs. The cellbased assay allows the minimization of using the animal models and can provide more relevant &lt;em&gt;in vivo &lt;/em&gt;biological information than biochemical assay. &lt;strong&gt;Objective:&lt;/strong&gt; We aimed to establish a simple cell-based screening assay for the discovery of lead extract against HSV-1. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Assay setting up was performed by optimization of the cell, incubation time, virus titer, and determination of Z value. &lt;strong&gt;Results: &lt;/strong&gt;We have successfully established reproducible methods, by setting up assay plate including determination: 1) Vero cells as a model for HSV-1 infection, 2) Incubation for 5 days as sufficient time for CPE endpoint at monolayer cells, 3) 100 TCID&lt;sub&gt;50&lt;/sub&gt;/well HSV-1 as infection titer which caused high percentage of cell detachment, 4) determination of Z value of 100 TCID&lt;sub&gt;50&lt;/sub&gt;/well infection &amp;gt; 0.5. In addition, the established system was tested using ACV as the most common anti-HSV drug. Furthermore, we demonstrated the current system to screen extracts from &lt;em&gt;Acacia nilotica, Uncaria gambir &lt;/em&gt;and &lt;em&gt;Aspalathus linearis &lt;/em&gt;against HSV-1. It was observed that the alkaline extract of Uncaria gambir exhibited the highest SI (12.5) compared to other extracts. &lt;strong&gt;Conclusion: &lt;/strong&gt;We demonstrated current cellbased screening system was reproducible and able to identify lead extracts against HSV-1 infection.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">251</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ratika Rahmasari&lt;sup&gt;1&lt;/sup&gt;, Takahiro Haruyama&lt;sup&gt;2&lt;/sup&gt;, Muhareva Raekiansyah&lt;sup&gt;3&lt;/sup&gt;, Farhana Mossadeque&lt;sup&gt;4&lt;/sup&gt;, Marina Ika Irianti&lt;sup&gt;1&lt;/sup&gt;, Ayun Erwina Arifianti&lt;sup&gt;1&lt;/sup&gt;, Nobuyuki Kobayashi&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Central Research Center, AVSS, Okinawa, JAPAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;PT Sciencewerke Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute of Tropical Medicine, Nagasaki University, Nagasaki, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Retno Susilowati</style></author><author><style face="normal" font="default" size="100%">Lailatul Khoiriyah</style></author><author><style face="normal" font="default" size="100%">Exma Mutatal Hikmah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Estrogenic Effect of the Leaves from Katuk (Sauropus androgynus L. Merr) on Vaginal and Endometrial Atrophy in Perimenopausal Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Endometrial atrophy</style></keyword><keyword><style  face="normal" font="default" size="100%">Estrogenic effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Laboratory mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Perimenopause</style></keyword><keyword><style  face="normal" font="default" size="100%">S. androgynus leaf extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Vaginal atrophy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">240-245</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To examine the potency of estrogenic effect of Katuk (or star gooseberry or sweet leaf) &lt;em&gt;Sauropus androgynus&lt;/em&gt; L. Merr (Phyllanthaceae) leaf extract on the vaginal and endometrial atrophy in perimenopausal mice model. &lt;strong&gt;Methods: &lt;/strong&gt;Completely random experiments divided into 4 groups with 5 female mice in each group: control group (N), perimenopause group which induced by 4-vynil cyclohexene dioxide (VCD) (P0), perimenopause group followed by &lt;em&gt;S. androgynus &lt;/em&gt;leaves extract administration with 15 and 30 mg/kg BW (P15 and P30). The mice were induced to artificial perimenopause with 160 mg/kg body weight (BW) of VCD 5 times/week for 2 weeks and continuously treated with &lt;em&gt;S. androgynus&lt;/em&gt; leaf extract for 30 days. Vaginal smear examination, maturation index (MI), vaginal epithelium and endometrial thickness were observed. Data were analyzed using a standard one-way ANOVA with LSD Test by SPSS 16.0 for Windows. &lt;strong&gt;Results: &lt;/strong&gt;Administration of &lt;em&gt;S. androgynus&lt;/em&gt; leaf extract for 30 days to perimenopausal mice model significantly decreased the duration of mice diestrus phase (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.01) compared to perimenopause mice.&lt;em&gt; S. androgynus &lt;/em&gt;leaf extract treatment at dose 30 mg/kg BW led to higher vaginal epithelium thickness and maturation index compared to another group (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.01). The effective dose to enhance the vaginal epithelial and endometrial cells proliferation was 30 mg/ kg BW. &lt;strong&gt;Conclusions:&lt;/strong&gt;&lt;em&gt; S. androgynus&lt;/em&gt; leaf extract had a good estrogenic action that it might be useful for therapy of vaginal and endometrial atrophy caused by perimenopause effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">240</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Retno Susilowati*, Lailatul Khoiriyah, Exma Mutatal Hikmah&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biology, Faculty of Science and Technology, State Islamic University of Maulana Malik Ibrahim Malang, Malang 65144, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">GS Deora</style></author><author><style face="normal" font="default" size="100%">Monika K Shekhawat</style></author><author><style face="normal" font="default" size="100%">Sarswati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical, Phytochemical and Pharmacological Potential of Cycas revoluta Thunb A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cycas revoluta</style></keyword><keyword><style  face="normal" font="default" size="100%">Endemic species</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1165-1171</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Cycas revoluta &lt;/em&gt;Thunb. or sago palm is an important species of cycads, endemically found in Japan, especially in southern Japan throughout the Ryukyu Island. The species is of massive ethnobotanical significance and used at large by the poor people and population of hilly areas in famine condition. It is mainly valued for its starch contains and used as fiber to construct cloth and ropes. It shows several pharmacological activities since different parts of this plant contain several chemicals like glycosides, amino acids, flavonoids, fatty acids and lectins. The aim of the present review is to compile all the informations available related to taxonomy, ethnobotany, chemical constituents and their pharmacological activities to explore the importance of &lt;em&gt;C. revoluta.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1165</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;G.S. Deora, Monika K. Shekhawat*, Sarswati &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Botany, University College of Science, M. L. Sukhadia University, Udaipur, Rajasthan, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siti Maisarah Zakaria</style></author><author><style face="normal" font="default" size="100%">Che Nurul Aini Che Amri</style></author><author><style face="normal" font="default" size="100%">Rozilawati Shahari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotany and Traditional Knowledge of Acanthaceae in Peninsular Malaysia A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acanthaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional Knowledge</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1482-1488</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Plants are considered as a great source of various herbal medicines which are been useful in the treatment of various ailments and diseases. A great contribution of plant-based materials in the pharmaceutical field results in the growing interest on the exploitation of indigenous medicinal plants to make a potential medicine. Several potent plant families are broadly investigated throughout the world including the family of Acanthaceae. Acanthaceae is a large pantropical family of flowering plants comprised of approximately 240 genera and 3250 species in the world. In Peninsular Malaysia, Acanthaceae is one of the families with the largest number of genera and species by which 29 genera and 158 species are respectively recorded. This study thereby deals with the review of information on the ethnobotanical significance of medicinal plants belong to Acanthaceae. This review covers informative data on medicinal plants, its uses and part used based on three tribal groups of indigenous people, Malay villagers and local market traders in Peninsular Malaysia. From the review, Acanthaceae possesses a huge contribution to the ethnobotanical part especially to treat certain diseases. The ethnobotanical data has also served a great contribution to the conservation and sustainability of natural resources. By keeping this point, this present review on ethnobotany and traditional knowledge of Acanthaceae is expected to give benefits and considered a good starting point for future works on the pharmaceutical field, especially for Peninsular Malaysia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1482</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siti Maisarah Zakaria, Che Nurul Aini Che Amri*, Rozilawati Shahari &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Plant Science, Kulliyyah of Science, International Islamic University of Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Divaker Shukla</style></author><author><style face="normal" font="default" size="100%">Kavita Gahlot</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antidiarrhoeal Activity of the Leaves and Stem of Bauhinia vahlii</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiarrhoeal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bauhinia vahlii</style></keyword><keyword><style  face="normal" font="default" size="100%">Castor oil induced diarrhea</style></keyword><keyword><style  face="normal" font="default" size="100%">Castor oil induced enteropooling</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1389-1394</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present study aimed to investigate the antidiarrhoeal activity of the traditional claim of &lt;em&gt;Bauhinia vahlii&lt;/em&gt; Wight and Arn. &lt;strong&gt;Method: &lt;/strong&gt;Dried ethanolic extracts of leaves and stem of the plant were used at two dose level (200 mg/ kg and 400 mg/kg p.o) screened separately for their antidiarrhoeal activity by Castor oil induced diarrhea and enteropooling in rats model. Result: The leaves extracts showed significant (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.001) antidiarrhoeal activity at 400 mg/kg in both the tested models. Conclusion: The findings of the present study provide clear idea and prove the traditional claim that ethanolic extracts of the leaves and stem of &lt;em&gt;Bauhinia vahlii&lt;/em&gt; (EEBVL and EEBVS).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1389</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Divaker Shukla*, Kavita Gahlot &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Pharmacognosy and Phytochemistry Laboratory, Faculty of Pharmacy, IFTM University, Moradabad-244001-INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tri Widyawati</style></author><author><style face="normal" font="default" size="100%">M Aron Pase</style></author><author><style face="normal" font="default" size="100%">Milahayati Daulay</style></author><author><style face="normal" font="default" size="100%">Imam Bagus Sumantri</style></author><author><style face="normal" font="default" size="100%">Nor Adlin Yusoff</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Myrmecodia pendans Water Extracts on Hematology Profiles, Liver, Kidney Function and Malondialdehyde Level in Healthy Volunteer</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Malondialdehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Myrmecodia pendans</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1489-1493</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ant Nest (&lt;em&gt;Myrmecodia pendans&lt;/em&gt;) is one of plants that have been used by locals in Indonesia to empirically treat various diseases. Ant Nest&lt;em&gt; in vitro &lt;/em&gt;and&lt;em&gt; in vivo &lt;/em&gt;studies on animals have been widely reported its pharmacological activities as an antioxidant. Unfortunately, scientific proofs reported on this plant as human medicine are still lacking.&lt;strong&gt; Aim: &lt;/strong&gt;This study aimed to ensure effectiveness, and safety due to administration of Ant Nest Water Extract (ANWE) formulated in capsule. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Twelve volunteers were divided into 2 groups, 6 volunteers in each group. Group I: Ant Nest Water Extract Capsule (ANWEC) in dose of 350 mg ANWE, and group II: Placebo Capsule (PC) which contained 350 mg amylum. Each groups given the capsule once daily for 28 days. The comparison was made between group I and group II. Hematology tests include hemoglobin, leucocyte and thrombocyte. Blood chemistry tests include SGOT, SGPT, total cholesterol, triglycerides, HDL, LDL, glucose, ureum (Ur) and creatinine (Cr). Malondialdehyde (MDA) level was measured at day-28 which was the last day of the intervention. &lt;strong&gt;Results: &lt;/strong&gt;After 28 days administration of ANWE, the SGOT, SGPT, Ur, and Cr showed in normal level as follows SGOT (U/L): 19.2 ± 3.99; SGPT (U/L): 17.2 ± 6.80; Ur (mg/dL): 19.75 ± 3.66; Cr (mg/dL): 1.06 ± 0.13. MDA (ng/mL) level in ANWEC-treated group was significantly lower (117.2±23.8) than PC (147.25±18.7). There was no intolerable complaints during the observation. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study concluded that Water Extract of Ant Nest 350 mg has no damage to liver, kidney and hematology, so it was proven that this plant is safed to be consumed by human for its potency as antioxidant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1489</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tri Widyawati&lt;sup&gt;1,&lt;/sup&gt;*, M. Aron Pase&lt;sup&gt;2&lt;/sup&gt;, Milahayati Daulay&lt;sup&gt;3&lt;/sup&gt;, Imam Bagus Sumantri&lt;sup&gt;4&lt;/sup&gt;, Nor Adlin Yusoff&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20222, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Integrative Medicine Cluster, Advance Medical and Dental Institute, Universiti Sains Malaysia, Penang, 13200, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sanjana Datta</style></author><author><style face="normal" font="default" size="100%">Shailendra Patil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Traditional Herb Extract Salvia officinalis in Treatment of Alzheimers Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alzheimer’s disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathological assessment</style></keyword><keyword><style  face="normal" font="default" size="100%">Locomotor activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Salvia officinalis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">131-143</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim and Objective: &lt;/strong&gt;Alzheimer’s disease is progressive neurodegenerative disorder which affects older individuals. It is the most common cause of dementia and it is associated with the presence of senile plaques which are deposition of beta- amyloidal protein in the hippocampus area of the brain. Medicinal plants have played vital role in world health. In spite of the great advances observed in modern medicine in recent decades, plants still make an important contribution to health care. The present study is done to evaluate &lt;em&gt;Salvia officinalis,&lt;/em&gt; for &lt;em&gt;in vivo &lt;/em&gt;study on Alzheimer’s disease induced mice. &lt;strong&gt;Materials and Methodology: &lt;/strong&gt;Memory Enhancing Activity, Conditioned avoidance test, Y-maze spontaneous alternation test, Elevated Plus Maze, Morris Water Maze, Measurement of Locomotor Activity were done to assess memory and cognitive functioning. The isolated brain homogenate is estimated for reduced glutathione content, Acetyl cholinesterase Activity, Superoxide dismutase assay (SOD), Lipid peroxidation assay (TBARS), Glutathione peroxidase assay (GSH-Px) and Histopathology examination of brain was performed and analyzed. &lt;strong&gt;Results and Discussion: &lt;/strong&gt;The elevated level of enzymes and decreased level of tissue antioxidant markers were observed in treatment comparative to piracetam treatment group. While 300 mg/kg extract significantly reduced the elevated levels of the enzymes and also significantly increased the tissue antioxidant levels, while decreased the glutathione levels when compared with the control. &lt;strong&gt;Conclusion: &lt;/strong&gt;The histopathological study confirmed the recovery. The herbal extract (150 and 300 mg/kg) has shown effectiveness against Alzheimer’s disease.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">131</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sanjana Datta*, Shailendra Patil&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar (MP) 470228, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sharada Laxman Deore</style></author><author><style face="normal" font="default" size="100%">Someshekhar S Khadabadi</style></author><author><style face="normal" font="default" size="100%">Bhushan A Baviskar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Expression of Heat-labile Enterotoxin of Escherichia coli in Biolistic Transformed Hairy Roots of Daucus carota L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carrot</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene gun</style></keyword><keyword><style  face="normal" font="default" size="100%">hairy root</style></keyword><keyword><style  face="normal" font="default" size="100%">LTB</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1440-1443</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Expression and secretion of recombination proteins in transgenic hairy roots have opened door to simple, feasible and economic option compared to animal and bacterial systems. Here, we report a feasibility study for producing the nontoxic B subunit of Escherichia coli heatlabile enterotoxin (LTB) in &lt;em&gt;Daucus carota&lt;/em&gt; L hairy root where transformation is achieved by biolistic gene gun method. &lt;em&gt;Agrobacterium rhizogenes &lt;/em&gt;strain (R-1000) cells containing synthetic LTB gene in pMYO51T plant expression vector under the CaMV 35S promoter introduced to &lt;em&gt;Daucus carota&lt;/em&gt; L roots by biolistic gene gun method. PCR amplification confirmed the integration of synthetic LTB gene in carrot hairy roots. Western blot analysis confirmed production of LTB pentamer in similar banding pattern to the native bacterial derived LTB. 0.50-0.70% of LTB protein estimated in carrot hairy roots. GM1-ganglioside assay indicated formation of biological active pentamers. LTB protein with biochemical properties identical to native LTB protein in the hairy roots of edible carrot roots opens the way for inexpensive, safe, and effective plant-based edible vaccines for humans and animals.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1440</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sharada Laxman Deore*, Someshekhar S. Khadabadi, Bhushan A. Baviskar &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Govt. College of Pharmacy, Kathora naka, Amravati-444604, MS, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Relin Yesika</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Extract of Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) Activity to Decrease IL-4 and IgE Levels in Type I Hypersensitivity White Male Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Allergies</style></keyword><keyword><style  face="normal" font="default" size="100%">Etlingera elatior (Jack) R.M.Sm</style></keyword><keyword><style  face="normal" font="default" size="100%">IgE</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-4</style></keyword><keyword><style  face="normal" font="default" size="100%">Kincung Flower</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">682-686</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Kincung Flower (&lt;em&gt;Etlingera elatior&lt;/em&gt; (Jack) R.M.Sm.) is a herbal plant which contains many secondary metabolites. It showed to suppress allergic reactions by inhibiting mast cell degranulation, active cutaneous anaphylaxis and decreasing the number of basophils and eosinophils. &lt;strong&gt;Aim: &lt;/strong&gt;The study conducted to determine the decreased IL-4 and IgE level of type I hypersensitivity male white mice using kincung flowers extract. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The maceration method used to make ethanol extract of Kincung flower (&lt;em&gt;Etlingera elatior&lt;/em&gt; (Jack) R.M.Sm.). The research used 25 allergic male white mice, which made by injected 20% albumen that given on the first day 0.2 mL/20 g intraperitoneally. On the seventh day are given albumen with the same dose subcutaneously. The characteristic of the allergic mice is the redness at the injection site. It divided into five groups: the negative control group, the positive control group and three dose groups (100; 300; and 1000 mg/kg). After mice given extract for seven days, then measured IgE and IL-4 levels in the serum of mice. &lt;strong&gt;Results:&lt;/strong&gt; The results after three dose groups (100; 300; and 1000 mg/kg) given, the negative and positive control group showed sequentially the IL-4 level was: 33.024; 27.933; 25.192; 23.130 and 41.538 ng/ mL. And IgE level in serum was 0.944; 0.629; 0.210; and 1,597 μg/ mL. &lt;strong&gt;Conclusion: &lt;/strong&gt;It concluded that kincung flowers decreased IL-4 and IgE level significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). So it could use as an anti-allergic drug.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">682</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Relin Yesika, Yufri Aldi &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, University Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ika Aulia Rahmi</style></author><author><style face="normal" font="default" size="100%">Mahdi Jufri</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extraction of Quercetin from Nothopanax scutellarium Leaves via Ionic Liquid-based Microwave-assisted Extraction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">Green extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Green technology</style></keyword><keyword><style  face="normal" font="default" size="100%">Ionic liquid</style></keyword><keyword><style  face="normal" font="default" size="100%">Mangkokan Leaf</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1512-1517</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Nothopanax scutellarium&lt;/em&gt; leaves have been used in Indonesian traditional medicine to treat several diseases. Previous studies used conventional extraction methods with large volumes of organic solvents, long extraction times, and low levels of quercetin content. This study was aimed to identify the optimal solvent among different ionic liquids that has the highest quercetin content. &lt;strong&gt;Methods: &lt;/strong&gt;Ionic liquids including 1-butyl-3-methylimidazolium bromide, 1-butyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium chloride, 1-butyl-3-methylimidazolium hydrogen sulfate, and 1-hexyl-3-methylimidazolium bromide, for extracting quercetin from&lt;em&gt; N. scutellarium&lt;/em&gt; leaves using microwave-assisted extraction under the following conditions: ratio, 1:10; operation time, 10 min; and power, 10 W. Then, quercetin was fractionated using ethyl acetate and separated using 0.01 mol/L sodium bocarbonate, dipotassium phosphate or sodium cloride. The total flavonoid content was determined using a UV-Vis spectrophotometer, and quercetin content was determined using HPLC. &lt;strong&gt;Results:&lt;/strong&gt; Extraction with 1-butyl-3-methylimidazolium chloride using NaCl as the separation salt was associated with the highest total flavonoid (360.57 mg/g) content among the ILs, whereas 1-butyl-3-methylimidazolium tetrafluoroborate combined with sodium chloride generated the highest quercetin content (26.13 mg/g). &lt;strong&gt;Conclusion:&lt;/strong&gt; 1-butyl-3-methylimidazolium tetrafluoroborate is the optimal solvent for extracting quercetin from &lt;em&gt;N. scutellarium &lt;/em&gt;leaves.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1512</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ika Aulia Rahmi&lt;sup&gt;1&lt;/sup&gt;, Mahdi Jufri&lt;sup&gt;2&lt;/sup&gt;, Abdul Mun’im&lt;sup&gt;3,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Program of Herbal, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department Pharmaceutical Technology and Drug Development, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Viani Anggi</style></author><author><style face="normal" font="default" size="100%">Magfirah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect Hypoglycemic of Ethanol Extract Combination Red Betel Leaf (Piper crocatum) and Dayak Onion (Eleutherine palmifolia Merr) in Streptozotocin-Induced</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dayak onion</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoglycemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Red betel leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1401-1405</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Red betel leaf and Dayak onion is used traditionally to treat diabetes mellitus, The use of this combination of extracts to assess the effectiveness of the combination therapy is getting better by working synergistically. &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to determine the hypoglycemic effect and the effective dose of ethanol extract combination of red betel leaf and Dayak onion of male rats (Rattus norvegicus). &lt;strong&gt;Methods: &lt;/strong&gt;The number of 35 male rats were divided into 7 groups and each group consisted of five rats. The first group (normal control) was given Na CMC; the second group (negative control) streptozotocin-induced ; the third group (positive control) glibenclamide , while the 4&lt;sup&gt;th&lt;/sup&gt;, 5&lt;sup&gt;th&lt;/sup&gt;,6&lt;sup&gt;th&lt;/sup&gt;, and 7&lt;sup&gt;th&lt;/sup&gt; were successively given a single dose of ethanol extract of red betel leaf 25 mg/KgBB, a single dose of Dayak onion50 mg/ KgBB, combination red betel leaf and forest onion bulbs, 25+50 and 50+100 mg/kg bb. Each rat group was intraperitoneally (IP) induced with STZ 40 mg/KgBB and then treated for 21 days. The hypoglycemic effect was tested by using the God- Pap method. &lt;strong&gt;Result: &lt;/strong&gt;Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were present in ethanol extract of red betel leaf and forest onion bulbs. The study concluded that the combination of red betel leaf and Dayak onion at doses 25 mg/KgBB and 50 mg/KgBB were synergistic in reducing glucose. &lt;strong&gt;Conclusion:&lt;/strong&gt; In conclusion, the ethanol extract combination of red betel leaf and dayak onion have hypoglycemic effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1401</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Viani Anggi*, Magfirah &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;College of Pharmaceutical Sciences Pelita Mas Palu, Central Sulawesi 94111, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pharnuwan Chanhan</style></author><author><style face="normal" font="default" size="100%">Ampa Konsue</style></author><author><style face="normal" font="default" size="100%">Rachanee Nammatra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Agricultural Model of using Fertilizer, Harvesting Time and Extraction Method on Phytochemical Contents and Antioxidant Activities from Mulberry Leaves Grown in Maha Sarakham Province, Thailand</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Fertilizer</style></keyword><keyword><style  face="normal" font="default" size="100%">Harvesting</style></keyword><keyword><style  face="normal" font="default" size="100%">Mulberry leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">531-535</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aims:&lt;/strong&gt; Phytochemical contents and free radical scavenging of Mulberry leaf extracts by using different fertilizer, time of harvesting and solvent extraction were evaluated. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Dried Mulberry leaves were extracted by using different solvent including aqueous, 50% ethanol and 95% ethanol. The phytochemical screening were determined by Total Phenolic Compounds (TPC) and Total Flavonoid Contents (TFC). The anti-oxidation were tested by using 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging and 2,2 -azinobis-(3- ethylbenzothiazoline-6-sulphonate) (ABTS&lt;sup&gt;+&lt;/sup&gt;) assay. &lt;strong&gt;Results: &lt;/strong&gt;This experimental study found that the mulberry leaf extract were given extraction with 95% ethanol, all of fertilizer and at Week 4 showed highest total phenolic contents espectcially BET2 was high amount of TPC (124.444±0.609 mgGE/gExt). The harvest time, all of groups at the Week 4 were significantly higher than all of groups at the Week 2. On the other hand, total flavonoid contents, the DET1 (Fertilizer formula 15-15-15, extraction with 95% ethanol at the Week 2; 110.913±3.208 mgQE/gExt) showed highest amount. The Antioxidant activities, DPPH free radical scavenging activity, The groups were given extraction with 95% ethanol, all of fertilizer at the Week 4 including CHT2 (IC&lt;sub&gt;50&lt;/sub&gt; =0.00459±0.00001 mg/mL), BHT2 (IC&lt;sub&gt;50&lt;/sub&gt; =0.00487 ±0.00005 mg/mL), AHT2 (IC&lt;sub&gt;50&lt;/sub&gt; =0.00499±0.00007 mg/mL), DHT2 (IC&lt;sub&gt;50&lt;/sub&gt; =0.00499±0.00005 mg/mL) and EHT2 (IC&lt;sub&gt;50&lt;/sub&gt; =0.00667 ±0.00039 mg/mL) were more potent on free radical scavenging higher than all of groups. The ABTS+ assay, at the Week 2 of all fertilizer groups were given with all solvent extraction including BHT1 (IC&lt;sub&gt;50&lt;/sub&gt; =0.03191±0.00257 mg/mL), CHT1 (IC&lt;sub&gt;50&lt;/sub&gt; =0.03247±0.00044 mg/mL), AHT1 (IC&lt;sub&gt;50&lt;/sub&gt; =0.03320±0.00120 mg/mL), EHT1 (IC&lt;sub&gt;50 &lt;/sub&gt;=0.03342±0.00116 mg/mL) and AAT1 (IC&lt;sub&gt;50&lt;/sub&gt; =0.03792±0.00076 mg/mL) showed free radical scavenging activity not different from standard substances, ascorbic acid (IC&lt;sub&gt;50&lt;/sub&gt; =0.00699 ±0.00004 mg/mL) and Trolox&lt;sup&gt;&lt;/sup&gt;&amp;nbsp;(IC&lt;sub&gt;50&lt;/sub&gt; =0.01594±0.00116 mg/mL).&lt;strong&gt; Conclusion:&lt;/strong&gt; The study was undertaken to investigate it’s fertilizer use, harvest time and extraction method for biologically activities also chemical composition contents and their antioxidant potentials. Therefore, our data might be help to good cultivation and harvesting practice selection in order to produce better of mulberry leaf production.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">531</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pharnuwan Chanhan&lt;sup&gt;1&lt;/sup&gt;, Ampa Konsue&lt;sup&gt;2&lt;/sup&gt;, Rachanee Nammatra&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Center of Excellence for Silk Innovation, Mahasarakham University, Maha Sarakham, 44150, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Thai Traditional Medicine Research Unit, Mahasarakham University, Maha Sarakham, 44000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Production and Quantity Control of Herbal Tea Laboratory, Biodiversity and Conservation Research Unit, Walai Rukhavej Botanical Research Institute, Mahasarakham University, Maha Sarakham, 44150, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Saksham Mathur</style></author><author><style face="normal" font="default" size="100%">Cheryl Sarah Philipose</style></author><author><style face="normal" font="default" size="100%">Ganaraja B</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Aqueous Extract of Liquorice (G. Glabra L) in Treatment of Stress Induced Gastric Ulcer in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Glycyrrhiza glabra</style></keyword><keyword><style  face="normal" font="default" size="100%">Immobilization stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Peptic ulcer</style></keyword><keyword><style  face="normal" font="default" size="100%">Prophylactic use</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1526-1531</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Peptic ulcer is a disease affecting a large number of people, caused due to various reasons including infection with &lt;em&gt;H pylori&lt;/em&gt;, consumption of alcohol, NSAIDs and stress. Although not a life-threatening disease, it causes undue distress and discomfort and accounts for increased time off from work thereby leading to manpower and economic losses. In this condition, histamine receptor blockers provide relief. &lt;strong&gt;Objectives:&lt;/strong&gt; Natural remedies for peptic ulcer have not been effectively utilized in clinical set up. In the present study, we evaluated the effect of water extract of &lt;em&gt;Glycyrrhiza Glabra&lt;/em&gt; L, commonly known as Liquorice on stressinduced gastric inflammation. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Liquorice extract was prepared. Male Wistar rats (&lt;em&gt;n&lt;/em&gt;=5 in each group) were procured from the central animal house and divided into four groups namely Group 1(control); Group 2 (low dose treatment); Group 3 (high dose treatment) and group 4 (prophylactic). They were housed individually and subjected to restraint stress in PVC pipes for 2 hours daily and their stomach was examined for ulcer in Licorice (oral) fed groups and control.&lt;strong&gt; Results:&lt;/strong&gt; Control group showed the inflammatory changes, ulcer index showed a significant lesion, whereas the animals treated with low dose and high dose showed proportionate decrease in the severity of inflammation as evidenced by the histological features. Fourth group of rats which was treated prophylactically before they were subjected to stress, showed no sign of stress-induced inflammatory changes in the gastric mucosa. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of this study strongly suggested that the G Glabra extract reduces the inflammation and relieves the ulcers and also it can be used as a prophylactic agent to prevent the peptic ulcer in vulnerable subjects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1526</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Saksham Mathur&lt;sup&gt;1&lt;/sup&gt;, Cheryl Sarah Philipose&lt;sup&gt;2&lt;/sup&gt;, Ganaraja B&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Kasturba Medical College, Mangalore (A constituent of Manipal Academy of Higher Education) INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pathology, Kasturba Medical College, Mangalore (A constituent of Manipal Academy of Higher Education) INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Additional Professor, Physiology, Kasturba Medical College, Centre for Basic Sciences, Bejai post, Mangalore – 575004. (A constituent of Manipal Academy of Higher Education, Manipal) INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Citra Bonnita Putri</style></author><author><style face="normal" font="default" size="100%">Sutriyo</style></author><author><style face="normal" font="default" size="100%">Herman Suryadi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Beta Glucosidase Inhibitor from Lichen Extract in Microcrystalline Cellulose Preparation from Water Hyacinth (Eichhornia crassipes)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Enzymatic hydrolysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Lichen extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Microcrystalline cellulose</style></keyword><keyword><style  face="normal" font="default" size="100%">Water hyacinthm</style></keyword><keyword><style  face="normal" font="default" size="100%">β-glucosidase inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1199-1203</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Microcrystalline cellulose (MCC) is an excipient commonly used in the manufacturing of pharmaceutical preparations, especially tablet. MCC has been successfully made from water hyacinth (&lt;em&gt;Eichhornia crassipes&lt;/em&gt;) through enzymatic hydrolysis process. This study aimed to find the effect of β-glucosidase inhibitor from lichen extract to the yield of MCC, the optimum conditions of enzymatic hydrolysis including pH and reaction time and characteristics of MCC obtained compared to reference, Avicel PH-101. &lt;strong&gt;Method: &lt;/strong&gt;The study was began with extraction of cellulose enzyme and followed by determination of optimum beta-glucosidase inhibitor concentration. Then, this conditions were used for enzymatic hydrolysis of α-cellulose to MCC, followed by identification and characterization of MCC obtained and compared with Avicel PH- 101. &lt;strong&gt;Results:&lt;/strong&gt; The optimum concentration of inhibitor was 120 ppm. A little higher yield of MCC was obtained when inhibitor extract is used in hydrolysis alfa-cellulose to MCC. The identity of MCC obtained was similar to infrared spectrum of reference. Other characteristics of MCC obtained were powder in the form of a slightly coarse, odorless and tasteless and slightly yellowish than reference. &lt;strong&gt;Conclusion:&lt;/strong&gt; Addition of extract of Beta glucosidase inhibitor did not improve the MCC yield significantly, but identity and characteristics of MCC obtained showed similarities to the microcrystalline cellulose reference (Avicel PH = 101).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1199</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Citra Bonnita Putri&lt;sup&gt;1&lt;/sup&gt;, Sutriyo&lt;sup&gt;2&lt;/sup&gt;, Herman Suryadi&lt;sup&gt;1&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Microbiology and Biotechnology, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author><author><style face="normal" font="default" size="100%">Marselani Kolobinti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Coriander Ethanol Extract (Coriandrum sativum L.) Against Phagocytosis Activity and Capacity of the Macrophage Cells and the Percentage of Leukocyte Cells in White Male Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Coriandrum sativum</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Macrophages</style></keyword><keyword><style  face="normal" font="default" size="100%">Phagocytosis capacity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1290-1298</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Coriander has long been used by humans as a traditional drug and to enhances the taste of foods. This study aims to know the effects of coriander ethanol extract against phagocytosis activity and capacity of the macrophage cells and the percentage of leukocytes. The test animals used were white male mice which divided into 4 groups and each group consists of 5 mice. The first group (control) was given with 0.5% Na CMC suspension. The second, the third, and the fourth groups were given with coriander extract each with doses of 100 mg/kg, 140 mg/kg and 200 mg/kg orally for 7 days long. On the 8th day, the mice were induced by &lt;em&gt;Staphylococcus aureus &lt;/em&gt;to help their immune system. The results showed that the administration of coriander extract at doses of 100, 140 and 200 mg/kg can increase the phagocytic activity of macrophages by 44.6%; 54.2%; and 60.2% each, while the phagocytic capacity replaces the results of 95.8; 104.4; and 126 cells. The total number of leukocytes showed were 5210, 6190, and 7310 /μL blood. In the number of leukocyte cells, the amount of coriander extract can reduce the number of neutrophil and monocyte cell segments. The conclusion of this study regarding coriander ethanol extract at doses of 100, 140 and 200 mg/kg can increase phagocytosis activity and capacity of the macrophage cells and the total leukocyte cell counts in male white mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1290</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dwisari Dillasamola*, Yufri Aldi, Marselani Kolobinti&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Department of Pharmacology, Andalas University, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prashanth kumar Goudappala</style></author><author><style face="normal" font="default" size="100%">Ethirajan Sukumar</style></author><author><style face="normal" font="default" size="100%">C V Yogaraje-Gowda</style></author><author><style face="normal" font="default" size="100%">Kashinath RT</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Diallyl Disulphide (DADS) on Gluconeogenesis: A Study in Isolated Alloxan Induced Diabetic Liver</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alloxan</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Diallyldisulphide</style></keyword><keyword><style  face="normal" font="default" size="100%">Gluconeogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose-6-phosphatase</style></keyword><keyword><style  face="normal" font="default" size="100%">Total amino acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Total keto acid</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">777-781</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Coordinated regulation between cellular glucose uptake and endogenous glucose production is indispensable for maintenance of constant blood glucose concentrations. Liver contributes significantly by altering levels of hepatic glucose release, through controlling gluconeogenesis. &lt;strong&gt;Objective: &lt;/strong&gt;To assess effect of Diallyldisulphide on hepatic gluconeogenesis by assessing gluconeogenic substrates and activity of regulatory enzyme glucose-6-phosphatase and to compare the Diallyldisulphide effect on gluconeogenesis with Metformin. &lt;strong&gt;Methodology:&lt;/strong&gt; Wistar albino rats were categorized into four groups; group Inormal control. Group II, III and IV rats were administered single intraperitoneal injection of alloxan monohydrate 150 mg/kg body weight. Rats were maintained on rat diet and water adlibitum for 30 days. On 31&lt;sup&gt;st&lt;/sup&gt; day rats were sacrificed and procured liver tissues. Each liver tissue cut into small slices and group-III and group-IV liver tissues were separately incubated with Diallyldisulphide 4 mg/g liver tissues and Metformin 4 mg/g liver tissues for 60 minutes at 37&lt;sup&gt;&lt;span style=&quot;font-size:10.8333px&quot;&gt;o&lt;/span&gt;&lt;/sup&gt;C. The total amino acids and total keto acids levels were estimated after exposure. And post exposure effect on activity of glucose -6-phoshatase and transaminases were also estimated. &lt;strong&gt;Results: &lt;/strong&gt;Alloxan induced diabetes resulted significant raise in total amino acids, total ketoacids, glucose -6-phosphatase and transaminases activities. Whereas incubation of liver tissues with diallyldisulphide significantly reduced total amino acids, total ketoacids, glucose-6-phosphatase, transaminases activities and ratio of total amino acids and ketoacids as compared to diabetic control rat liver tissues. &lt;strong&gt;Conclusion: &lt;/strong&gt;Study suggested that diallyldisulphide suppressed gluconeogenesis as liver glucose-6-phosphatase activity is significantly decreased and precursors for gluconeogenesis were significantly reduced. Suggesting Diallyldisulphide has role in gluconeogenesis and can hold potentials for glucose homeostasis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">777</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prashanth kumar Goudappala&lt;sup&gt;1,2&lt;/sup&gt;, Ethirajan Sukumar&lt;sup&gt;1&lt;/sup&gt;, C V Yogaraje- Gowda&lt;sup&gt;3&lt;/sup&gt;, Kashinath RT&lt;sup&gt;4,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Research and Development, Saveetha Institute of Medical and Technical Science (Deemed University), Thandalam, Chennai-602 105, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Subbaiah Institute of Medical Sciences, Purle, Shivamogga-577 222, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Bangalore Medical College, Bangalore, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Research and Development, Subbaiah Institute of Medical Sciences, Purle, Shivamogga-577 222, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dharma S</style></author><author><style face="normal" font="default" size="100%">Rahmawati Y</style></author><author><style face="normal" font="default" size="100%">Nessa</style></author><author><style face="normal" font="default" size="100%">Dillasamolla S</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Fibroblast Growth Factor Combination with Ethanol Extract of Morinda citrifolia L. on Blood Glucose Levels</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">FGF</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda citrifolia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1558-1562</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;A research has been conducted on the effect of giving Fibroblast Growth Factor (FGF) with &lt;em&gt;Morinda citrifolia&lt;/em&gt; L. ethanol extract. This study aims to determine whether the administration of a combination of FGF with ethanol extract of noni fruit can reduce blood glucose levels in diabetes mice induced by alloxan. FGF requires amino acids in regenerating pancreatic &lt;em&gt;β&lt;/em&gt; cells, where the amino acids expected from noni fruit can provide a signal response in regenerating pancreatic &lt;em&gt;β&lt;/em&gt; cells. In addition, the active substances contained in noni fruit namely xeronine and flavonoid alkaloids can function to reduce blood glucose levels. Test animals were divided into 6 groups, each group consisted of 10 male white mice. Group 1 is a normal control group is a group without any given. Group 2 was a negative control group given 150 mg/kg alloxan. Group 3, 4, and 5 are the treatment groups that are given alloxan and the combination of noni fruit ethanol extract with 3 variations of dose (125; 350; and 1000) mg / KgBW plus FGF dose of 800 mg / kgBW, group 6 is the comparison which is only given FGF alone at a dose of 800 mg / kgBW. The study was conducted for 21 days, observed every 7&lt;sup&gt;th&lt;/sup&gt;, 14&lt;sup&gt;th&lt;/sup&gt;, 21&lt;sup&gt;st &lt;/sup&gt;day using the Easy Touch&lt;sup&gt;®&amp;nbsp;&lt;/sup&gt;GCU digital device. The results of this study showed that administration of noni fruit ethanol extract with FGF was able to reduce blood glucose levels by significance (&lt;em&gt;p &lt;/em&gt;&amp;lt;0.05) and based on the percentage calculation of blood glucose levels as much as 44.9% at a dose of 1000 mg / kgBW on the day observations 21&lt;sup&gt;st&lt;/sup&gt;.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1558</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dharma S&lt;sup&gt;1,&lt;/sup&gt;*, Rahmawati Y&lt;sup&gt;2&lt;/sup&gt;, Nessa&lt;sup&gt;2&lt;/sup&gt;, Dillasamolla S&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Indonesian Pioneer Pharmacy College, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rezi Riadhi Syahdi</style></author><author><style face="normal" font="default" size="100%">Aditya Sindu Sakti</style></author><author><style face="normal" font="default" size="100%">Agung Kristiyanto</style></author><author><style face="normal" font="default" size="100%">Riky Redmawati</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Gamma Irradiation on Some Pharmacological Properties and Microbial Activities of Melinjo (Gnetum gnemon Linn.) Seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Dipeptidyl peptidase-4</style></keyword><keyword><style  face="normal" font="default" size="100%">Gamma irradiation</style></keyword><keyword><style  face="normal" font="default" size="100%">Gnetum gnemon</style></keyword><keyword><style  face="normal" font="default" size="100%">HMG-CoA reductase</style></keyword><keyword><style  face="normal" font="default" size="100%">Resveratrol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">177-182</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Ionizing radiation, such as gamma irradiation, serves as a useful approach to inhibit spore germination and to control pathogens in postharvest seeds. Recently, its application on phytochemical sources and its influence on antioxidant activity of various phytochemical compounds has become an interesting topic to be explored.&lt;strong&gt; Objective:&lt;/strong&gt; The objectives of this study were to determine the effect of gamma irradiation as sterilization method on the resveratrol content and its antioxidant, HMG-CoA reductase inhibitory and dipeptidyl peptidase-4 (DPP-4) inhibitory activities of Melinjo (&lt;em&gt;Gnetum gnemon&lt;/em&gt;) seeds. &lt;strong&gt;Methods:&lt;/strong&gt; In this research, melinjo seeds were irradiated by 0.0; 2.5; 5.0; 7.5; and 10.0 kGy with gamma irradiation and then extracted with ethanol. The extracts were tested for resveratrol content with HPLC, antioxidant activities by DPPH assay, HMG-CoA inhibitory activity using HMG-CoA reductase assay kit and DPP-4 inhibitory activity using DPP-4 Inhibitor Screening Assay Kit. Gamma irradiation has effect on resveratrol content, antioxidant activity, HMG-CoA reductase inhibition and DPP-4 inhibitory activity. &lt;strong&gt;Results:&lt;/strong&gt; From the research, the highest value of resveratrol content is 0.18±0.004 mg/g seeds powder found in 5.0 kGy gamma irradiation treatment with IC50 94.64±0.236 μg/mL, while the highest HMG-CoA reductase inhibition is shown in 2.5 kGy irradiation dose. Melinjo seeds irradiated by 2.5 kGy gamma irradiation also shown a significant increase of DPP-4 inhibition activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study suggests that 2.5-5 kGy radiation is the effective gamma irradiation dose to improve the quality of melinjo seeds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">177</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rezi Riadhi Syahdi&lt;sup&gt;1&lt;/sup&gt;, Aditya Sindu Sakti&lt;sup&gt;2&lt;/sup&gt;, Agung Kristiyanto&lt;sup&gt;2&lt;/sup&gt;, Riky Redmawati&lt;sup&gt;2&lt;/sup&gt;, Abdul Mun’im&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Departement of Medicinal Chemistry, Analysis and Biomedics Laboratory, Faculty of Pharmacy, Universitas INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Laboratory, Faculty of Pharmacy, Universitas INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Pharmacognosy-Phytochemistry, Universitas INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Phunchok Angmo</style></author><author><style face="normal" font="default" size="100%">Sonam Chorol</style></author><author><style face="normal" font="default" size="100%">Desyong Namgail</style></author><author><style face="normal" font="default" size="100%">OP Chaurasia</style></author><author><style face="normal" font="default" size="100%">Tsering Stobdan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Maturation on Phenolics and Flavonoids Content of Greenhouse-Grown Beet Leaf</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Greenhouse</style></keyword><keyword><style  face="normal" font="default" size="100%">Ladakh</style></keyword><keyword><style  face="normal" font="default" size="100%">Maturity</style></keyword><keyword><style  face="normal" font="default" size="100%">Vegetable</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1010-1013</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aims to determine how maturation stages of greenhouse-grown beet leaf influence the total phenolic content (TPC) and total flavonoid content (TFC). &lt;strong&gt;Methods:&lt;/strong&gt; Beet leaf was grown under two different passive solar greenhouses in trans-Himalayan Ladakh. Leaves harvested at three maturity stages were evaluated for TPC and TFC. &lt;strong&gt;Results: &lt;/strong&gt;Significant difference in TPC and TFC was observed between the three maturity stages. Midmature leaves had the highest TPC and TFC followed by mature and immature leaves. When TPC and TFC for all maturity stages were averaged, a marked difference in TPC and TFC was observed in beet leaf grown under the two passive solar greenhouses. Higher TPC and TFC were observed in the greenhouse with higher photosynthetically active radiation (PAR) and UV-transmittance. &lt;strong&gt;Conclusion:&lt;/strong&gt; Beet leaf should be harvested at the midmaturity stage for consumer to benefit from elevated levels of phenolics and flavonoids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1010</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Phunchok Angmo, Sonam Chorol, Desyong Namgail, OP Chaurasia, Tsering Stobdan*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Defence Institute of High Altitude Research, Defence R &amp;amp; D Organisation, Leh- Ladakh-194101, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author><author><style face="normal" font="default" size="100%">Hasanatul Khairiyah</style></author><author><style face="normal" font="default" size="100%">Nila Kasuma</style></author><author><style face="normal" font="default" size="100%">Afriwardi</style></author><author><style face="normal" font="default" size="100%">Agus Sri Banowo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Noni Fruit Extract (Morinda citrifolia L.) in Gingivitis Patient</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chlorhexidine</style></keyword><keyword><style  face="normal" font="default" size="100%">Gingival index</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda citrifolia L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Mouthwash</style></keyword><keyword><style  face="normal" font="default" size="100%">Noni fruit extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">678-682</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Antiseptic mouthwash (chlorhexidine and povidone iodine) is usually used to decrease the number of colonies of pathogenic bacteria. But, somehow it gives side effect if it used for a long time. So, it should take another alternative as a raw material to make a mouthwash with minimal side effects, economical and efficacious. &lt;strong&gt;Aim: &lt;/strong&gt;The aim of this research was to examine the effect of noni fruit extract (&lt;em&gt;Morinda citrifolia &lt;/em&gt;L.) that given as mouthwash on 15 gingivitis patients.&lt;strong&gt; Materials and Methods: &lt;/strong&gt;The research was conducted for 7 days in a row and gingival index of each patient was measured before and after the treatment. The patients were divided into 3 group and given 3 different treatments. Group I used mouthwash noni fruit extract 5%; Group II used chlorhexidine 0.1%; and Group III used a mixture of extracts of noni: chlorhexidine (2.5% : 0.05%). The mouthwash was used in the morning and at the night before going to sleep as much as 15 ml and gargling it for 30 sec. &lt;strong&gt;Results: &lt;/strong&gt;The results showed the gingival index was declined in every group treatment (mouthwash noni fruit extract 5%, chlorhexidine 0.1% and a mixture of extracts of noni: chlorhexidine (2.5% : 0.05%). The differences between each group were not significant (&lt;em&gt;p&lt;/em&gt; &amp;gt; 0.05).&lt;strong&gt; Conclusion:&lt;/strong&gt; Despite it give the same effect, the extract of noni fruit should be used as an alternative to mouthwash because it gives the same effect as much as chlorhexidine and it also economical, efficacious and minimal side effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">678</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yufri Aldi&lt;sup&gt;1,*&lt;/sup&gt;, Hasanatul Khairiyah&lt;sup&gt;1&lt;/sup&gt;, Nila Kasuma&lt;sup&gt;2&lt;/sup&gt;, Afriwardi&lt;sup&gt;3&lt;/sup&gt;, Agus Sri Banowo&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departement Oral Biology, Faculty of Dentistry, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department Physiology Medicine, Faculty of Medicine, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department Mental Health and Community Nursing, Faculty of Nursing, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Inbaraj SD</style></author><author><style face="normal" font="default" size="100%">Muniappan M</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Ocimum sanctum Leaf Extract on Entero-Insular Axis by Oral Glucose Tolerance Test in Albino Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antihyperglycemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Entero-Insular axis</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucagon</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin</style></keyword><keyword><style  face="normal" font="default" size="100%">Ocimum sanctum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1138-1142</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This research study evaluates the effect of &lt;em&gt;Ocimum sanctum&lt;/em&gt; leaf extract on the entero-insular axis and the hyperglycemia due to oral glucose tolerance test in albino rats. Methanolic leaf extract of &lt;em&gt;Ocimum sanctum&lt;/em&gt; was prepared by Sami labs, Bangalore and used for the study. After obtaining Institutional Animal ethical committee clearance male albino rats (155–215 g) were divided into 4 groups. 6 albino rats were randomly assigned to Control (Normal saline) group, Standard (Vildagliptin 50 mg/kg) group, &lt;em&gt;Ocimum sanctum&lt;/em&gt; leaf extract (100 mg/kg) and (200 mg/kg) groups. After overnight fasting the baseline biochemical evaluation in the fasting state blood glucose, Insulin level, Glucagon level, GLP-1 (Glucagon like peptide-1), GIP (Glucose dependent Insulinotropic peptide) level were measured for all the above groups. Control, Vildagliptin (STD) and the extracts were orally administered by using rat oral feeding tube. 30 minutes later oral glucose tolerance test (OGTT) was done. Blood samples were evaluated for blood sugar, Insulin, Glucagon, GLP-1 and GIP at 0, 15 and 45 minutes after oral glucose load. &lt;em&gt;Ocimum sanctum&lt;/em&gt; (200 mg/kg) showed significant (p ≤ 0.05) reduction in blood glucose at 45 minutes when compared to control. &lt;em&gt;Ocimum sanctum&lt;/em&gt; (100 mg/kg &amp;amp; 200 mg/kg) showed significant (p ≤ 0.001) increase in GIP levels at 45 minutes of OGTT.&lt;em&gt; Ocimum sanctum&lt;/em&gt; leaf extract showed significant antihyperglycemic and incretin enhancing effects. Further indepth animal and clinical studies are necessary to demonstrate the therapeutic potential of this extract for the treatment of type 2 diabetes mellitus.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1138</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Inbaraj SD*, Muniappan M &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacology, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research [BIHER], Chennai, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Towseef Hassan</style></author><author><style face="normal" font="default" size="100%">Elanchezhiyan C</style></author><author><style face="normal" font="default" size="100%">Insha Naseer</style></author><author><style face="normal" font="default" size="100%">S Marimuthu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Perillyl Alcohol (POH) A Monoterpene on Lipid Peroxidation and Antioxidant Status in High Fat Diet-Low Dose STZ Induced Type 2 Diabetes in Experimental Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">High Fat Diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Perillyl alcohol</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1434-1441</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The plan of this study was to assess the protective activity of Perillyl alcohol (POH) on the levels of lipid peroxidation (LPO) by-products and antioxidant defense systems in the plasma and other tissues of normal and High Fat Diet-Low Dose Streptozotocin (STZ) induced type 2 diabetes in wistar rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The experimental diabetes was induced in animals by High Fat Diet-Low Dose STZ (35 mg/kg i.p.) injection, and treatment with Perillyl alcohol at the dose of (50mg/kg b.w and 100mg/kg b.w) was continued for 30 days. At the end of treatment period, oxidative stress parameters like lipid peroxidation by-products; enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-enzymic antioxidants including reduced glutathione, Vitamin C and Vitamin E were measured in the plasma and tissues of experimental rats. &lt;strong&gt;Results:&lt;/strong&gt; In untreated diabetic rats an increase was seen in the levels of lipid peroxidation by-products and significant decrease was seen in antioxidant enzymes. Oral administration of Perillyl alcohol a monocyclic monoterpene to diabetic rats for 30 days caused a significant reduction in the levels of lipid peroxidation by-products and an increase in the activities of antioxidant enzymes, when the same were compared with the untreated diabetic group. &lt;strong&gt;Conclusion:&lt;/strong&gt; The result of this study indicates that Perillyl alcohol has anti lipid peroxidation and antioxidant status potential in experimental diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1434</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Towseef Hassan, Elanchezhiyan C*, Insha Naseer, S. Marimuthu&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Zoology, Annamalai University, Annamalainagar, Chidambaram-608002, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Porana paniculata Whole Plant on Blood Glucose Levels and Lipid Profile of STZ Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Folklore</style></keyword><keyword><style  face="normal" font="default" size="100%">lipid profile</style></keyword><keyword><style  face="normal" font="default" size="100%">Porana paniculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2019</style></date></pub-dates></dates><pages><style face="normal" font="default" size="100%">xx-xx</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Background&lt;/strong&gt;: To establish the antidiabetic potential of Porana paniculata whole plant belongs to &lt;em&gt;Convolvulaceae&lt;/em&gt; family. &lt;strong&gt;Methods&lt;/strong&gt;: Extraction and preliminary phytochemical screening were conducted by standard methods. Antidiabetic activity was evaluated by streptozotocin induced diabetic rats where the hydroalcoholic extract of plant was administered orally at a dose of 250 and 500 mg/kg for 30 days. Blood glucose levels were estimated at 1&lt;sup&gt;st&lt;/sup&gt;, 10&lt;sup&gt;th&lt;/sup&gt;, 20&lt;sup&gt;th&lt;/sup&gt; and 30&lt;sup&gt;th&lt;/sup&gt; day of study. Lipid profile was studied 30&lt;sup&gt;th&lt;/sup&gt; day of study and body weight of the animals was measured at day 1 and 30.&lt;strong&gt; Results&lt;/strong&gt;: Plant extract significantly (&lt;em&gt;p&amp;lt;&lt;/em&gt;0.01) reduced the blood glucose levels at both the tested dose levels of 250 and 500 mg/kg. The lipid profile was estimated in which the plant extract showed significant improved in both tested dose level that is 250 and 500 mg/kg. The body weight of the animals under study was also estimated on day 1 and 30 in which a good control was observed by the plant extract. &lt;strong&gt;Conclusion&lt;/strong&gt;: Antidiabetic activity of Porana paniculata whole plant extract may be due to the presence of various phytoconstituents. Present study gives a scientific evidence for the folklore claim of the plant under study for its use in diabetes.&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">xx</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Sanjeeva Kumar A&lt;sup&gt;1,&lt;/sup&gt;*, Raveendra Reddy Juturu&lt;sup&gt;1&lt;/sup&gt;, Rama Mohan Gupta Vankadari&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Pharmacognosy, Raghavendra Institute of Pharmaceutical Education and Research, Krishnam Reddy Palli cross, Chiyyedu, Anantapuramu-515721, Andhra Pradesh, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pulla Reddy Institute of Pharmacy, Near Dundigal Air force Academy, Annaram Village, Jinnaram Mandal, Medak- 502313, Andhra Pradesh, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sanjeeva Kumar A</style></author><author><style face="normal" font="default" size="100%">Raveendra Reddy Juturu</style></author><author><style face="normal" font="default" size="100%">Rama Mohan Gupta Vankadari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Porana paniculata Whole Plant on Blood Glucose Levels and Lipid Profile of STZ Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Folklore</style></keyword><keyword><style  face="normal" font="default" size="100%">lipid profile</style></keyword><keyword><style  face="normal" font="default" size="100%">Porana paniculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2019</style></date></pub-dates></dates><pages><style face="normal" font="default" size="100%">xx-xx</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; To establish the antidiabetic potential of &lt;em&gt;Porana paniculata&lt;/em&gt; whole plant belongs to Convolvulaceae family. &lt;strong&gt;Methods:&lt;/strong&gt; Extraction and preliminary phytochemical screening were conducted by standard methods. Antidiabetic activity was evaluated by streptozotocin induced diabetic rats where the hydroalcoholic extract of plant was administered orally at a dose of 250 and 500 mg/kg for 30 days. Blood glucose levels were estimated at 1&lt;sup&gt;st&lt;/sup&gt;, 10&lt;sup&gt;th&lt;/sup&gt;, 20&lt;sup&gt;th&lt;/sup&gt; and 30&lt;sup&gt;th&lt;/sup&gt; day of study. Lipid profile was studied 30&lt;sup&gt;&lt;s&gt;th&lt;/s&gt;&lt;/sup&gt; day of study and body weight of the animals was measured at day 1 and 30.&lt;strong&gt; Results:&lt;/strong&gt; Plant extract significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.01) reduced the blood glucose levels at both the tested dose levels of 250 and 500 mg/kg. The lipid profile was estimated in which the plant extract showed significant improved in both tested dose level that is 250 and 500 mg/kg. The body weight of the animals under study was also estimated on day 1 and 30 in which a good control was observed by the plant extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; Antidiabetic activity of &lt;em&gt;Porana paniculata&lt;/em&gt; whole plant extract may be due to the presence of various phytoconstituents. Present study gives a scientific evidence for the folklore claim of the plant under study for its use in diabetes.&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">xx</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sanjeeva Kumar A&lt;sup&gt;1*&lt;/sup&gt;, Raveendra Reddy Juturu&lt;sup&gt;1&lt;/sup&gt;, Rama Mohan Gupta Vankadari&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Pharmacognosy, Raghavendra Institute of Pharmaceutical Education and Research, Krishnam Reddy Palli cross, Chiyyedu, Anantapuramu-515721, Andhra Pradesh, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pulla Reddy Institute of Pharmacy, Near Dundigal Air force Academy, Annaram Village, Jinnaram Mandal, Medak- 502313, Andhra Pradesh, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Roberto Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz Cerrate</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Luz Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Sacha Inchi Oil (Plukenetia volubilis L.) on Genotoxicity in Mice (Mus musculus) and Subchronic Toxicity in Goldfish (Carassius auratus)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Genotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha Inchi Oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Subchronic Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1549-1557</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Plukenetia volubilis&lt;/em&gt; is known as Sacha Inchi (SI) is originary from the peruvian amazone and it has been cultivated and consumed since the pre and Inca's time. &lt;strong&gt;Objective: &lt;/strong&gt;Sacha inchi oil was assessed for genotoxicity in Balb C albino mice and subchronic toxicity in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;). &lt;strong&gt;Material and Methods:&lt;/strong&gt; The genotoxicity was assessed in Mus musculus Balb C (&lt;em&gt;n&lt;/em&gt; = 25) separated into five groups randomly selected of twenty-five each one. Groups were 10 mL / kg normal saline (NS), 40 mg / kg cyclophosphamide group (CP) and the three other groups received cyclophosphamide and sacha inchi oil of concentrations 10, 100 and 1000 mg / kg respectively. The substances were administered three times during 24 hours. The genotoxicity in mice was evaluated determining micronucleus levels in blood and bone marrow. The subchronic toxicity was assessed in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;) (&lt;em&gt;n &lt;/em&gt;= 48) separated into four groups randomly selected of six each: normal saline group (control) and three groups that received doses of 10, 100 and 1000 μg sacha inchi oil per litre of water respectively for 45 days. &lt;strong&gt;Results:&lt;/strong&gt; The values of weight, length, growth rate, condition factor (K) and number of survivors were recorded. CP group showed higher micronuclei levels in blood and bone marrow compared with sacha inchi oil 10, 100 and 1000 mg / kg groups (ANOVA Test &lt;em&gt;p&lt;/em&gt; &amp;lt;0.01 Scheffe´s Post Hoc &lt;em&gt;p &lt;/em&gt;&amp;lt;0.05, &lt;em&gt;p &lt;/em&gt;&amp;lt;0.01 and &lt;em&gt;p&lt;/em&gt; &amp;lt;0.001 respectively). The subchronic toxicity assessment in goldfish showed isometric growth, a decline in &quot;K&quot; and a similar specific percentage growth rate per day in all groups (ANOVA test &lt;em&gt;p&lt;/em&gt;&amp;gt; 0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;Sacha inchi oil was not toxic under experimental conditions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1549</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Jorge Luis Arroyo-Acevedo&lt;sup&gt;2&lt;/sup&gt;, Roberto Chávez-Asmat&lt;sup&gt;3&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;2&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz Cerrate&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Luz Chacaltana-Ramos&lt;sup&gt;7&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;8 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Association for the Development of Student Research in Health Sciences (ADIECS), Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho 05001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Cientifica del Sur, Lima 15001, PERU&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima 15001, Peru.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Universidad Continental, Huancayo 12002, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author><author><style face="normal" font="default" size="100%">Joko Wahyuwibowo</style></author><author><style face="normal" font="default" size="100%">Aziz Rakha D</style></author><author><style face="normal" font="default" size="100%">Dede Rizky P</style></author><author><style face="normal" font="default" size="100%">Ahmad Fauzi N</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Tender Coconut Water to Prevent Anemia on Wistar Rats Induced by Lead (Plumbum)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Lead (Pb)</style></keyword><keyword><style  face="normal" font="default" size="100%">Tender coconut water</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1325-1330</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Tender coconut water (TCW) is a nutritious healthy drink, some content as L-arginin, iron, vitamin C, vitamin B6, folic acid and fatty acid have roles during the process of blood formation (hematopoesis). Lead (Pb) is one of heavy metal which can trigger the formation of &lt;em&gt;Reactive Oxygen Species&lt;/em&gt; (ROS), causing oxidative stress and &lt;em&gt;hematopoetic stem cell&lt;/em&gt; disorders which cause the decrease of hematocrit, hemoglobin and erythrocyte levels as the sign of anemia. &lt;strong&gt;Aim and Objectives: &lt;/strong&gt;This research to investigate the effect of tender coconut water to prevent anemia on lead induced rats. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Experimental research by post test only control group design, using 18 white wistar strain male rats randomly divided into 3 groups. Group K1 served as control, Group K2 was fed lead (10 mg/day/rat), Group K3 was given tender coconut water (8 mL/200gr BW rats/ day) orally for four weeks. Rats’ blood from ophtalmicus venous was analyzed using &lt;em&gt;Hematology Analyzer&lt;/em&gt; to measure the hemoglobin, hematocrit, and erythrocyte levels. Data were analyzed using Anova test and &lt;em&gt;Kruskal Wallis. &lt;/em&gt;&lt;strong&gt;Results:&lt;/strong&gt;That decreased levels of hematocrit, hemoglobin and erythrocyte were show in group K2 compared with group K1. Increased levels of hematocrit, hemoglobin and erythrocyte were observed significantly in both groups K3 than K2. &lt;strong&gt;Conclusion: &lt;/strong&gt;Results of the present study have administration of tender coconut water (8 mL/200gr BW rats/ day for 4 weeks) could increased of hematocrit, hemoglobin and erythrocyte levels (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.05). The administration of tender coconut water has proven to prevent the anemia indicated by the increase of hematocrit, hemoglobin and erythrocyte levels on wistar strain male rats induced by lead.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1325</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siti Thomas Zulaikhah&lt;sup&gt;1&lt;/sup&gt;,*, Joko Wahyuwibowo&lt;sup&gt;1&lt;/sup&gt;, Aziz Rakha D&lt;sup&gt;2&lt;/sup&gt;, Dede Rizky P&lt;sup&gt;2&lt;/sup&gt;, Ahmad Fauzi N&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Public Health Sciences, Faculty of Medicine, Sultan Agung Islamic University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Student Faculty of Medicine, Sultan Agung Islamic University (UNISSULA) Semarang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">SD Inbaraj</style></author><author><style face="normal" font="default" size="100%">M Muniappan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Trigonella Foenum Graecum Seed Extract on Entero- Insular Axis by Oral Glucose Tolerance Test in Albino Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antihyperglycemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Entero-Insular axis</style></keyword><keyword><style  face="normal" font="default" size="100%">GIP</style></keyword><keyword><style  face="normal" font="default" size="100%">GLP-1</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucagon</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin</style></keyword><keyword><style  face="normal" font="default" size="100%">Trigonella foenum graecum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1371-1375</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The research study evaluates the effect of &lt;em&gt;Trigonella foenum graecum&lt;/em&gt; seed extract on the entero-insular axis and the hyperglycemia due to oral glucose tolerance test in albino rats. Methanolic seed extract of &lt;em&gt;Trigonella foenum graecum&lt;/em&gt; was prepared by Sami labs, Bangalore and used for the study. Institutional Animal ethical committee clearance obtained. Male albino rats (155–215 g) were divided into 4 groups each having 6 albino rats were randomly assigned Control (Normal saline) group, Standard (Vildagliptin 50 mg/kg group), &lt;em&gt;Trigonella foenum graecum&lt;/em&gt; seed extract (100 mg/kg) and (200 mg/kg) groups. After overnight fasting the baseline biochemical evaluation in the fasting state blood glucose, Insulin level, Glucagon level, GLP- 1 (Glucagon like peptide-1), GIP (Glucose dependent Insulinotropic peptide) level were measured at -30 minutes for all the above groups. Control, Vildagliptin (STD) and the extracts were orally administered by using rat oral feeding tube. 30 minutes later oral glucose tolerance test (OGTT) was done. Blood samples were evaluated for blood sugar, Insulin, Glucagon, GLP- 1and GIP at -30, 0, 15 and 45 minutes after oral glucose load. &lt;em&gt;Trigonella foenum graecum &lt;/em&gt;(2 gm/kg) showed significant reduction in blood glucose (&lt;em&gt;p&lt;/em&gt;= &amp;lt;0.001) at 45 minutes when compared to control. &lt;em&gt;Trigonella foenum graecum&lt;/em&gt; (1 gm/kg and 2 gm/kg) showed significant (&lt;em&gt;p&lt;/em&gt;=&amp;lt;0.001) increase in GIP levels at 45 minutes of OGTT and (1 gm/kg) showed reduction in glucagon levels (&lt;em&gt;p&lt;/em&gt;=&amp;lt; 0.001) at 15 minutes and at 45 minutes (&lt;em&gt;p&lt;/em&gt;=&amp;lt;0.05). &lt;em&gt;Trigonella foenum graecum&lt;/em&gt; extracts showed significant antihyperglycemic and incretin enhancing effects through entero-insular axis. Further in-depth animal and clinical studies are necessary to bring out the therapeutic potential of this seed extract for the treatment of type 2 diabetes mellitus.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1371</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;SD Inbaraj*, M Muniappan &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacology, Sree Balaji Medical college and Hospital, Bharath Institute of Higher Education and Research [BIHER]. No.7 works road, Chromepet, Chennai- 600044, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">T Sundarrajan</style></author><author><style face="normal" font="default" size="100%">V Velmurugan</style></author><author><style face="normal" font="default" size="100%">MK Kathiravan</style></author><author><style face="normal" font="default" size="100%">K Manikandan</style></author><author><style face="normal" font="default" size="100%">KS Lakshmi</style></author><author><style face="normal" font="default" size="100%">MR Ganesh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Ultraviolet-B Radiation Exposure on Hibiscus cannabinus Linn with its Phytochemical and Pharmacological Responses</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cancer cells line HT-29</style></keyword><keyword><style  face="normal" font="default" size="100%">Hibiscus cannabinus Linn</style></keyword><keyword><style  face="normal" font="default" size="100%">Total Phenolic Contents</style></keyword><keyword><style  face="normal" font="default" size="100%">UV-B radiation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1540-1543</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;Exposure of UV-B Radiation on&amp;nbsp;&lt;em&gt;Hibiscus cannabinus&lt;/em&gt; Linn and to evaluate both Phytochemical and Pharmacological responses. &lt;strong&gt;Objective:&lt;/strong&gt; UV-B can increase the nutrients contents from plants, plants become tastier and increases the yield and UV-will make plants resistant to fungal infections and stimulate the production of phytomarkers. &lt;strong&gt;Material and Methods: &lt;/strong&gt;&lt;em&gt;Hibiscus cannabinus&lt;/em&gt; Linn seeds were soaked with 50% H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; for 12 hours and then inoculated with the Azospirillum. UV-B radiation cabinet was provided by UV lamps which are above 15 cm from control maintained. Normal daylight exposed control group Seedlings irradiated for 2 hour per day (12.30 pm to 2.30 pm) for 20 days. &lt;strong&gt;Results and Discussion: &lt;/strong&gt;20 days treatment increases total phenolic contents and sugars content were decreased in uncovered leaf tissue. Protein content was at first diminished but expanded on the 20 day of UV-B treatment. Also, perform pharmacological studies no toxic elements are observed 20 days treatment and pharmacological activity by using anticancer activity by using human colon HT-29 cancer cell line. UV light exposed plants shows good anticancer activity when compared with non UV exposed Plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1540</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;T Sundarrajan&lt;sup&gt;1,&lt;/sup&gt;*, V Velmurugan&lt;sup&gt;1&lt;/sup&gt;, MK Kathiravan&lt;sup&gt;2&lt;/sup&gt;, K Manikandan&lt;sup&gt;3&lt;/sup&gt;, KS Lakshmi&lt;sup&gt;3&lt;/sup&gt;, MR Ganesh&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry SRM College of Pharmacy, SRMIST, Kattankulathur, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;209, Dr. APJ Abdul Kalam Research Lab SRM College of Pharmacy, SRMIST, Kattankulathur, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRMIST, Kattankulathur, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;IIISM, SRM IST, Kattankulathur, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eka Sunarwidhi Prasedya</style></author><author><style face="normal" font="default" size="100%">Ni Wayan Riyani Martyasari</style></author><author><style face="normal" font="default" size="100%">Candra Dwipayana Hamdin</style></author><author><style face="normal" font="default" size="100%">Masao Miyake</style></author><author><style face="normal" font="default" size="100%">Daisuke Kobayashi</style></author><author><style face="normal" font="default" size="100%">Sri Widyastuti</style></author><author><style face="normal" font="default" size="100%">Akihiro Hazama</style></author><author><style face="normal" font="default" size="100%">Haji Sunarpi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of Methanol Solvent Extraction for Red Macroalgae Acanthophora spicifera Antitumoric Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acanthophora</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiproliferative</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesia</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroalgae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">450-454</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Red macroalgae &lt;em&gt;Acanthophora spicifera&lt;/em&gt; is commonly found in most parts of Indonesia coastal areas. However, information regarding their potential pharmaceutical uses remains largely unexplored. This study evaluates the antiproliferative activity of &lt;em&gt;Acanthophora spicifera&lt;/em&gt; collected from Indonesian extracted with different solvents of ethanol and methanol. &lt;strong&gt;Methods:&lt;/strong&gt; Cytotoxicity and antiproliferative activity of &lt;em&gt;A. spicifera&lt;/em&gt; crude ethanol extract (AS-EtOH) and &lt;em&gt;A. spicifera&lt;/em&gt; crude methanol extract (AM-MetOH) were evaluated with Lactate dehidrogenase (LDH) and Trypan blue exclusion assay in Human cervical cancer (HeLa) cells for 72h. Concentration of extracts treated in HeLa cells were 6.25 to 200 &lt;em&gt;μ&lt;/em&gt;g/mL. Viability staining with fluorescence stain Hoechst33342/PI was conducted to investigate apoptotic activity. Potential apoptotic activity of treatments was confirmed by DNA fragmentation assay. &lt;strong&gt;Results:&lt;/strong&gt; AS-MetOH demonstrated high cytotoxicity in HeLa cells with IC&lt;sub&gt;50&lt;/sub&gt; of 127.3 ± 33.13 &lt;em&gt;μ&lt;/em&gt;g/mL. However, AS-EtOH IC&lt;sub&gt;50&lt;/sub&gt; values could not be determined in this study. Antiproliferative activity was highly significant in AS-MetOH treated cells as cell density was suppressed to 20 x 10&lt;sup&gt;4&lt;/sup&gt; cells/mL compared to AS-EtOH (73 x 10&lt;sup&gt;4&lt;/sup&gt; cells/mL) and untreated cells (83 x 10&lt;sup&gt;4&lt;/sup&gt; cells/mL). Finally, apoptotic activity could be determined in AS-MetOH treated cells with increase PI fluorescence emitting cells and DNA fragmentation. On the other hand, apoptotic activity was not observable in AS-EtOH treated cells based on fluorescence viability staining and DNA fragmentation assay. &lt;strong&gt;Conclusion:&lt;/strong&gt; Current results show methanol solvent as an effective solvent to promote potential pharmaceutical properties of macroalgae &lt;em&gt;A. spicifera. &lt;/em&gt;Further advanced studies in a compound level from&lt;em&gt; A. spicifera&lt;/em&gt; methanol fraction would be reasonable for development of macroalgae based anticancer agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">450</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Eka Sunarwidhi Prasedya&lt;sup&gt;1&lt;/sup&gt;, Ni Wayan Riyani Martyasari&lt;sup&gt;2&lt;/sup&gt;, Candra Dwipayana Hamdin&lt;sup&gt;2&lt;/sup&gt;, Masao Miyake&lt;sup&gt;4&lt;/sup&gt;, Daisuke Kobayashi&lt;sup&gt;4&lt;/sup&gt;, Sri Widyastuti&lt;sup&gt;3&lt;/sup&gt;, Akihiro Hazama&lt;sup&gt;4&lt;/sup&gt;, Haji Sunarpi&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Bioscience and Biotechnology Research Centre, Faculty of Mathematics and Natural Sciences, University of Mataram, Nusa Tenggara Bar- 83126, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Medical Faculty, University of Mataram, Nusa Tenggara Bar-83126 INDONSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Food Science and Agroindustrial Technology, University of Mataram, Nusa Tenggara Bar-83126 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Cellular and Integrative Physiology, Fukushima Medical University, Fukushima, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vinodini NA</style></author><author><style face="normal" font="default" size="100%">Pratik Kumar Chatterjee</style></author><author><style face="normal" font="default" size="100%">Kunal</style></author><author><style face="normal" font="default" size="100%">Suman VB</style></author><author><style face="normal" font="default" size="100%">Rashmi KS</style></author><author><style face="normal" font="default" size="100%">Nayanatara AK</style></author><author><style face="normal" font="default" size="100%">Anupama N</style></author><author><style face="normal" font="default" size="100%">Ramesh M. Bhat</style></author><author><style face="normal" font="default" size="100%">Sheela Joice P</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of Moringa oleifea Extract in Attenuating the Toxic Effect on Platelet Count: An Experiment on Cadmium Exposed Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cadmium</style></keyword><keyword><style  face="normal" font="default" size="100%">Clotting Mechanisms</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Platelet Count</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">689-693</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aims and Objective:&lt;/strong&gt; To determine the role of &lt;em&gt;Moringa oleifera&lt;/em&gt; on total platelet count alterations (T-PC) in rats treated with cadmium. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;In the present study female adult Wistar Albino rats, (180-200) gm were divided into, Group I-normal control, Group II-pretreated control, group III-cadmium treated , group IV- pre-treated with &lt;em&gt;Moringa oleifera &lt;/em&gt;leaf extract (MOE) and then administered oral cadmium for a day, with &lt;em&gt;n&lt;/em&gt;=6 each &lt;strong&gt;Results: &lt;/strong&gt;Indicate that the pre-treatment with MOE (100 mg/kg/bw) prior to cadmium infusion augmented the level of total platelet count (&lt;em&gt;p&lt;/em&gt;≤0.001) as compared to the cadmium-exposed group, which might have a role in clotting mechanisms also. &lt;strong&gt;Conclusion: &lt;/strong&gt;&lt;em&gt;Moringa oleifera &lt;/em&gt;extract has a beneficial effect on platelet count in cadmium-induced animal model.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">689</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vinodini NA&lt;sup&gt;1&lt;/sup&gt;, Pratik Kumar Chatterjee&lt;sup&gt;1,*&lt;/sup&gt;, Kunal&lt;sup&gt;1&lt;/sup&gt;, Suman VB&lt;sup&gt;1&lt;/sup&gt;, Rashmi KS&lt;sup&gt;1&lt;/sup&gt;, Nayanatara AK&lt;sup&gt;1&lt;/sup&gt;, Anupama N&lt;sup&gt;1&lt;/sup&gt;, Ramesh M. Bhat&lt;sup&gt;1&lt;/sup&gt;, Sheela Joice P&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Physiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physiology, MES Medical College, Perinthalmanna, Kerala, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nkiru Nwamaka Ezeani</style></author><author><style face="normal" font="default" size="100%">Udu Ama Ibiam</style></author><author><style face="normal" font="default" size="100%">Obasi Uche Orji</style></author><author><style face="normal" font="default" size="100%">Ikechuku Okorie Igwenyi</style></author><author><style face="normal" font="default" size="100%">Chinyere Aloke</style></author><author><style face="normal" font="default" size="100%">Esther Alum</style></author><author><style face="normal" font="default" size="100%">Partrick Mmaduabuchi Aja</style></author><author><style face="normal" font="default" size="100%">Okechukwu Paul Chima Ugwu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Aqueous and Ethanol Root Extracts of Olax subscopioidea on Inflammatory Parameters in Complete Freund’s Adjuvant-Collagen Type II Induced Arthritic Albino Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adjuvant</style></keyword><keyword><style  face="normal" font="default" size="100%">Arthritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Indomethacine</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">16-25</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aim/Background:&lt;/strong&gt; Rural and Urban dwellers in Nigeria claim to treat their arthritis with &lt;em&gt;Olax subscorpioidea&lt;/em&gt; root extracts. One of the reasons they chose this treatment is that it is effective and cost less than orthodox drugs with their accompanying side effects. Hence the aim of this study is to investigate the anti-arthritis effects of &lt;em&gt;Olax subscorpioidea &lt;/em&gt;Afzel ethanol and aqueous root extracts on chicken type II-Complete Freund’s adjuvant (CFA) induced arthritis rat model. &lt;strong&gt;Materials and Method:&lt;/strong&gt; The anti-arthritic potential of ethanol and aqueous root extracts of &lt;em&gt;Olax subscorpioidea&lt;/em&gt; was evaluated using the chicken type II-Complete Freund’s adjuvant model in 135 female wistar albino rats. The rats were treated with aqueous and ethanol root extracts of &lt;em&gt;Olax subscorpioidea&lt;/em&gt; at varying doses and standard indomethacine drug. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol and aqueous root extracts of &lt;em&gt;Olax subscorpioidea &lt;/em&gt;showed significant anti-arthritic activity that was statistically similar to that of indomethacine. Our results suggest that the alcoholic extract of &lt;em&gt;Olax subscorpioidea &lt;/em&gt;showed significant (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05) anti-arthritic potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">16</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nkiru Nwamaka Ezeani&lt;sup&gt;*&lt;/sup&gt;, Udu Ama Ibiam, Obasi Uche Orji, Ikechuku Okorie Igwenyi, Chinyere Aloke, Esther Alum, Partrick Mmaduabuchi Aja, Okechukwu Paul Chima Ugwu &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Biochemistry, Ebonyi State University, Abakaliki, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Annisa Shabrina</style></author><author><style face="normal" font="default" size="100%">Herman Suryadi</style></author><author><style face="normal" font="default" size="100%">Sutriyo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Beta Glucosidase Inhibitor on Cellulase Enzyme Activity for Preparation of Microcrystalline Cellulose from Water Hyacinth (Eichhornia crassipes)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Charaterization</style></keyword><keyword><style  face="normal" font="default" size="100%">Enzyme hydrolyisis</style></keyword><keyword><style  face="normal" font="default" size="100%">Microcrystalline cellulose</style></keyword><keyword><style  face="normal" font="default" size="100%">Water hyacinth</style></keyword><keyword><style  face="normal" font="default" size="100%">β-glucosidase inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1225-1230</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Microcrystalline cellulose (MCC) was a highly desirable excipient which being used for making tablets with direct compression method in Pharmaceutical manufacture. The purpose of this study was to compare microcrystalline cellulose preparation from water hyacinth powder with and without addition of β-glucosidase inhibitor followed by identification and characterization of the resulting powders. &lt;strong&gt;Methods:&lt;/strong&gt; The study was began with isolation of potential organisms from soils in mangrove followed by extraction of • -glucosidase inhibitor. MCC was prepared through enzymatic hydrolysis of alpha-cellulase with and without addition of beta-glucosidase inhibitor. Identification was done using FTIR, then characterized by organoleptic examination, qualitative analysis, starch test, pH test, Scanning Electron Microscopy (SEM) analysis of particle size and distribution, X-ray Diffraction (XRD), moisture content, loss on drying test, particle density test, flow rate test and angle of repose test compared to microcrystalline cellulose which had been available on the market.&lt;strong&gt; Results: &lt;/strong&gt;The hydrolysis conditions were carried out at 30°C, for 2 h and the powder was dissolved in acetate buffer pH 7 by addition of enzyme and 2.5 ml inhibitor. MCC yield with addition of beta-glucosidase inhibitor (80%) was higher than without addition of beta-glucosidase (68%). &lt;strong&gt;Conclusion: &lt;/strong&gt;Addition of beta glucosidase inhibitor showed positive impact to increase MCC yield from alpha cellulose sample.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1225</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Annisa Shabrina&lt;sup&gt;1&lt;/sup&gt;, Herman Suryadi&lt;sup&gt;1&lt;/sup&gt;,*, Sutriyo&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Microbiology and Biotechnology, Faculty of Pharmacy, Universitas Indo-nesia, Depok 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Irani Binti Alloha</style></author><author><style face="normal" font="default" size="100%">Nurul ‘Ain Liyana Binti Aziz</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author><author><style face="normal" font="default" size="100%">Zurainie Abllah</style></author><author><style face="normal" font="default" size="100%">Mohd Hafiz Arzmi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Eurycoma Longifolia Jack (Tongkat Ali) Alcoholic Root Extract Against Oral Pathogens</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antifungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Candida albicans</style></keyword><keyword><style  face="normal" font="default" size="100%">Eurycoma longifolia Jack</style></keyword><keyword><style  face="normal" font="default" size="100%">Lactobacillus casei.</style></keyword><keyword><style  face="normal" font="default" size="100%">Root extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptococcus mutans</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1299-1302</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Eurycoma longifolia jack (E.L) is a herbal medicinal plant of South-East Asian origin, popularly recognized as ‘Tongkat Ali.’ The plant roots have been scientifically proven to have many biological effects including antibacterial activity however, no previous research to date has studied the effect on oral pathogens including cariogenic bacteria. This study was done to determine the antibacterial and antifungal activities of E.L. root extract against three common oral pathogens. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The microorganisms used were &lt;em&gt;Candida albicans, Streptococcus mutans &lt;/em&gt;and &lt;em&gt;Lactobacillus casei.&lt;/em&gt; E.L root was extracted using soxhlet method. Disc diffusion assay was conducted using extract concentration of 200 mg/ml. Nystatin and Ampicillin were used as positive control for fungal and bacterial tests respectively. Minimum Inhibitory Concentration (MIC) was done to determine the lowest inhibitory concentration of the extract on the microorganisms. &lt;strong&gt;Results: &lt;/strong&gt;E.L extract inhibited the growth of Candida albicans and Streptococcus mutans at a concentration of 200 mg/ ml with a zone of inhibition of 16.0 ± 3.0 mm and 7.0 ± 1.0 mm respectively. There was no antimicrobial effect of the extract on Lactobacillus casei. The MIC of E.L extract against both Candida albicans and Streptococcus mutans was 25 mg/ml. &lt;strong&gt;Conclusions: &lt;/strong&gt;The results from this study revealed the potential use of Eurycoma longifolia jack as an antimicrobial agent which can be used to produce new oral care products.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1299</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Irani Binti Alloha&lt;sup&gt;1&lt;/sup&gt;, Nurul ‘Ain Liyana Binti Aziz&lt;sup&gt;1&lt;/sup&gt;, Ghasak Ghazi Faisal&lt;sup&gt;2&lt;/sup&gt;,*, Zurainie Abllah&lt;sup&gt;3&lt;/sup&gt;, Mohd Hafiz Arzmi&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Students, Kuliyyah of Dentistry, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Lecturer, Fundamental Dental and Medical Sciences Department Kuliyyah of Dentistry, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Paediatric Dentistry and dental public health, IIUM, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nalita Phaiboon</style></author><author><style face="normal" font="default" size="100%">Pawitra Pulbutr</style></author><author><style face="normal" font="default" size="100%">Bunleu Sungthong</style></author><author><style face="normal" font="default" size="100%">Sakulrat Rattanakiat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of the Ethanolic Extracts of Guava Leaves, Licorice Roots and Cloves on the Cariogenic Properties of Streptococcus mutans</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cariogenic properties</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycyrrhiza glabra</style></keyword><keyword><style  face="normal" font="default" size="100%">Psidium guajava</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptococcus mutans</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium aromaticum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1029-1036</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Streptococcus mutans&lt;/em&gt; is a major causative pathogen of dental caries. This study aimed to investigate the effects of the ethanolic extracts of &lt;em&gt;Psidium guajava&lt;/em&gt;, &lt;em&gt;Glycyrrhiza glabra&lt;/em&gt; and &lt;em&gt;Syzygium aromaticum&lt;/em&gt; against cariogenic properties of &lt;em&gt;Streptococcus mutans&lt;/em&gt;. These medicinal plants have been used traditionally as the ingredients in the herbal mouthwash for the management of dental caries. &lt;strong&gt;Methods:&lt;/strong&gt; The 95% ethanolic extracts of these medicinal plants were prepared and their phytochemical contents were analyzed by using thin layer chromatography-densitometry. Antibacterial activities of the extracts against &lt;em&gt;S. mutans&lt;/em&gt; were evaluated according to broth dilution method. The effects of the extracts against cariogenic properties of &lt;em&gt;S. mutans&lt;/em&gt;, which are surface adherence, biofilm formation and acid production, were also investigated. &lt;strong&gt;Results: &lt;/strong&gt;The biological active constituents, quercetin, glycyrrhizic acid and eugenol, were found in &lt;em&gt;P. guajava, G. glabra and S. aromaticum&lt;/em&gt;, respectively. The three extracts possessed anti-bacterial activity against&lt;em&gt; S. mutans&lt;/em&gt; with the MICs of 1.562, 0.195 and 1.562 mg/mL, respectively. The extracts at every concentration tested (at lower than their MICs) significantly inhibited cariogenic properties of &lt;em&gt;S. mutans&lt;/em&gt;, which included inhibitions against surface adherence, biofilm formation and acid production. &lt;strong&gt;Conclusion:&lt;/strong&gt; The ethanolic extracts of guava leaves, licorice roots and cloves produced anti-bacterial and anti-cariogenic activities against &lt;em&gt;S. mutans&lt;/em&gt;. These plant extracts thus can potentially be developed as a product for the prevention of dental caries in the near future.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Research Article</style></work-type><section><style face="normal" font="default" size="100%">1029</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nalita Phaiboon, Pawitra Pulbutr, Bunleu Sungthong, Sakulrat Rattanakiat*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Pharmaceutical Chemistry and Natural Product Research Unit (PCNRU), Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham 44150, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nitin Govindrao Dumore</style></author><author><style face="normal" font="default" size="100%">Milind Janrao Umekar</style></author><author><style face="normal" font="default" size="100%">Brijesh Gulabrao Taksande</style></author><author><style face="normal" font="default" size="100%">Manish Manohar Aglawe</style></author><author><style face="normal" font="default" size="100%">Nandkishor Ramdasji Kotagale</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Withania somnifera Nicotine Induced Conditioned Place Preference in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Condition place preference</style></keyword><keyword><style  face="normal" font="default" size="100%">Nicotine</style></keyword><keyword><style  face="normal" font="default" size="100%">Withania somnifera</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">43-47</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Herbal medicines can be novel treatment strategies for management of nicotine addiction. Withania somnifera (Ashwagandha) is an Indian medicinal plant of great medicinal value; used in many clinically proven conditions. Objective: In present study we aimed at investigating the effect of withania somnifera extract (WSE) on preventing nicotine mediated effects attributed for the development of addiction. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Mice were treated with nicotine and/or WSE and subjected to nicotine induced conditioned place preference (CPP) in male albino mice was checked.&lt;strong&gt; Results: &lt;/strong&gt;Application of two-way ANOVA showed that with preconditioning and post-conditioning values as a within-subjects (column) factor and treatment as an independent between subject (row) factor. Two-way ANOVA revealed significant effect of treatment [F(3,40)=4.119, p&amp;lt;0.05], time [F(1,40)=23.76, p&amp;lt;0.001] and interactiontreatment x time [F(3,40)=5.244, p&amp;lt;0.01] on Intra-peritoneal (ip) administration of nicotine (1 mg/kg). WSE did not produce any changes in the preference to drug-paired compartment. Factors like treatment [F(3,40) = 0.656, p&amp;gt;0.05], time [F(1,40) = 7.383, p&amp;lt;0.01] and interactiontreatment x time [F(3,40) = 0.5748, p&amp;gt;0.05] showed insignificant effects. Withania somnifera (50,100,200 mg/kg ip) coadministered with nicotine during the 6 days conditioning sessions completely abolished the acquisition of nicotine-induced CPP in mice. &lt;strong&gt;Conclusion:&lt;/strong&gt; Above data indicate that withania somnifera attenuate nicotine induced CPP. Hence it has potential as an anti-addictive therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">43</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nitin Govindrao Dumore&lt;sup&gt;1,2*&lt;/sup&gt;, Milind Janrao Umekar&lt;sup&gt;1&lt;/sup&gt;, Brijesh GulabraoTaksande&lt;sup&gt;1&lt;/sup&gt;, Manish Manohar Aglawe&lt;sup&gt;1&lt;/sup&gt;, Nandkishor Ramdasji Kotagale&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Neuroscience, Department of Pharmacology, Smt.kishoritai Bhoyar College of pharmacy Kamptee, Nagpur 441002 Maharashtra, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Dadasaheb Balpande College of Pharmacy, Besa, Nagpur,440037 Maharashtra, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, Government college of Pharmacy, Amaravati, 444601, Maharashtra, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ahmad Najib</style></author><author><style face="normal" font="default" size="100%">Aktsar Roskiana Ahmad</style></author><author><style face="normal" font="default" size="100%">Virsa Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">ELISA Test on Cordia myxa L. Leaf Extract for alpha-Glucosidase Inhibitor</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acarbose</style></keyword><keyword><style  face="normal" font="default" size="100%">Cordia myxa L.</style></keyword><keyword><style  face="normal" font="default" size="100%">ELISA</style></keyword><keyword><style  face="normal" font="default" size="100%">IC50</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">358-361</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aimed:&lt;/strong&gt; Determine the potential of &lt;em&gt;Cordia myxa&lt;/em&gt; L. leaf on inhibited α-glucosidase. Material: ELISA Kit, Ethanol 96%, Colomn Chromatography, n-hexane, ethyl acetate, Glocobay®.&amp;nbsp; &lt;strong&gt;Method:&lt;/strong&gt; Sample from &lt;em&gt;Cordia myxa&lt;/em&gt; L. leaf extracted by ethanol 96% then evaporated to get the sticky extract. The sticky extract of &lt;em&gt;Cordia myxa&lt;/em&gt; L. leaf fractionated by column chromatography with n-hexane, n-hexane: ethyl acetate (90:10; 80:20; 75:25; 70:30; 65:35; 60:40; 55:45; 50:50) &lt;strong&gt;Assay:&lt;/strong&gt; The fractions assayed by ELISA (Enzyme-Linked Immunosorbent Assay) with acarbose (Glucobay ®) as the comparator.&lt;strong&gt; Result:&lt;/strong&gt; The results showed that the n-hexane fraction is the highest potency on inhibited α-glucosidase with the noncompetitive mechanism. The IC&lt;sub&gt;50&lt;/sub&gt; of n-hexane fraction is 0.53 ppm been while the acarbose is 6.85 ppm. &lt;strong&gt;Conclusion:&lt;/strong&gt; The n-hexane fraction of &lt;em&gt;Cordia myxa&lt;/em&gt; L. leaf has the highest potency to use for possible decrease blood glucose level.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">358</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ahmad Najib&lt;sup&gt;1,*&lt;/sup&gt;, Aktsar Roskiana Ahmad&lt;sup&gt;1&lt;/sup&gt;, Virsa Handayani&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Phytochemistry Division-Pharmacognosy- Phytochemistry Laboratory, Faculty of Pharmacy Universitas Muslim Indonesia, Makassar- INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy Division-Pharmacognosy- Phytotochemistry Laboratory, Faculty of Pharmacy Universitas Muslim Indonesia, Makassar- INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Retno Prihatiningtyas</style></author><author><style face="normal" font="default" size="100%">Rezi Riadhi Syahdi</style></author><author><style face="normal" font="default" size="100%">Masteria Yunovilsa Putra</style></author><author><style face="normal" font="default" size="100%">Arry Yanuar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Establishment of a 3D-structure Database for Chemical Compounds in Indonesian Sponges</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2D-and 3D-chemical structures</style></keyword><keyword><style  face="normal" font="default" size="100%">3D-database of chemical structures</style></keyword><keyword><style  face="normal" font="default" size="100%">Evaluation of software packages</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesian sponges</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1211-1218</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Nowadays, There hasn’t any three-dimensional (3D) chemical structure database yet for biologically active compound in sponges from Indonesian origin. Therefore, this study aimed to create &lt;em&gt;in silico&lt;/em&gt; a 3D-structure database of such compound and to evaluate the preferred software for this purpose. &lt;strong&gt;Methods:&lt;/strong&gt; 2D- structure of selected compounds was established using MarvinSketch software. Conversion from 2D- into 3D-structures was evaluated by comparing MarvinSketch, OpenBabel and VegaZZ software packages. Visualization of the respective 3D-structures was perfomed by using PyMOL software. From 68 scientific articles, 212 chemical compounds were selected from 53 Indonesian sponge species. &lt;strong&gt;Results: &lt;/strong&gt;The conversion of 2D-structures of the selected 212 chemical compound into 3D-structures lead to 7118 files, respectively consisting of 2508 files from the MarvinSketch, 1672 files from the OpenBabel and 1051 files from the VegaZZ software. The results based on the extention files were 1043 SDF, 1258 MOL and 2930 PDB format files of the three-dimensional structure. The valid and correct three-dimensional structure of chemical compound were 914 .sdf format files, 916 format .mol files and 72 .pdb format files. From the three-dimensional structures visualization, the database prefers established by using MarvinSketch with SDF or MOL format files since the results is consistent to literature and contain less number of errors.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1211</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Retno Prihatiningtyas&lt;sup&gt;1&lt;/sup&gt;, Rezi Riadhi Syahdi&lt;sup&gt;1&lt;/sup&gt;, Masteria Yunovilsa Putra&lt;sup&gt;2&lt;/sup&gt;, Arry Yanuar&lt;sup&gt;1&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Biomedical Computation and Drug Design Laboratory, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Center for Oceanography, Indonesian Institute of Sciences, Jl. Pasir Putih I, Ancol Timur, Jakarta 14430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ogochukwu Izuegbuna</style></author><author><style face="normal" font="default" size="100%">Gloria Otunola</style></author><author><style face="normal" font="default" size="100%">Graeme Bradley</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Estimation of Phytochemical, Vitamins Composition and Antioxidant Activity of Pelargonium inquinans Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancers</style></keyword><keyword><style  face="normal" font="default" size="100%">Pelargonium inquinans</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">237-244</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Aims&lt;/strong&gt;: To estimate the phytochemical and vitamins composition and the antioxidant activity of &lt;em&gt;Pelargonium inquinans &lt;/em&gt;leaves. &lt;strong&gt;Background&lt;/strong&gt;: Some plants that are used in the traditional setting for the management of different ailments have documented observations and scientific studies. However many other plants lack scientific reports to support their medicinal use. One of such plant is &lt;em&gt;Pelargonium inquinans &lt;/em&gt;Ait that is traditionally used to treat headaches and flu by tribes in South Africa. Not much is known about its chemical composition. &lt;strong&gt;Methods&lt;/strong&gt;: The phytochemical composition of acetone, aqueous and ethanol extract of leaves of &lt;em&gt;Pelargonium inquinans&lt;/em&gt; as well as the vitamins A, C and E of its dried weight leaves and the antioxidant activities were evaluated using standard in vitro methods. The phytochemical composition and vitamins were determined spectrophotometrically, while the antioxidant activities were determined by DPPH, nitric oxide and hydrogen peroxide scavenging activity and phosphomolybdenum (total) antioxidant activity. &lt;strong&gt;Statistical analysis&lt;/strong&gt;: The One-way analysis of variance (ANOVA) and the Tukey test were used to determine the differences among the means of the various samples. &lt;strong&gt;Results&lt;/strong&gt;: The phytochemical composition differ significantly in the various extracts. The total phenolics were higher than other phytochemicals in all the extracts used. The hydrogen peroxide and DPPH scavenging activity were very high and dose-dependent. The aqueous extract had the highest antioxidant activity at 98.4 % of control (hydrogen peroxide), while the ethanol extract had the lowest at 37.5% control (nitric oxide). &lt;strong&gt;Conclusion&lt;/strong&gt;: The results supports the notion that the Geraniaceae family and &lt;em&gt;Pelargonium inquinans&lt;/em&gt; in particular is rich in polyphenolic compounds and has good antioxidant activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">237</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Ogochukwu Izuegbuna&lt;sup&gt;1&lt;/sup&gt;, Gloria Otunola&lt;sup&gt;2&lt;/sup&gt;, Graeme Bradley&lt;sup&gt;1,* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Science and Agric. University of Fort Hare, Alice, 5700, SOUTH AFRICA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, Medicinal Plants and Economic Development (MPED) Research Institute, University of Fort Hare, 5700, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusnandar Anggadiredja</style></author><author><style face="normal" font="default" size="100%">I Ketut Adnyana</style></author><author><style face="normal" font="default" size="100%">Dewi Safitri</style></author><author><style face="normal" font="default" size="100%">Siti Farah Rahmawati</style></author><author><style face="normal" font="default" size="100%">Tomi Hendrayana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethanol Extract of Gardenia augusta (L.) Merr. Flowers Produces Sleep Improvement in Rat Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flowers</style></keyword><keyword><style  face="normal" font="default" size="100%">Gardenia augusta (L.) Merr.</style></keyword><keyword><style  face="normal" font="default" size="100%">Improvement</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Sleep</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1449-1454</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sleep disorder may have detrimental consequences on health and one of the treatments is the use of hypnotics. Unfortunately, hypnotics treatment may also be accompanied by side effects and lead to dependence. The present study aimed to investigate the sleep improving effects of ethanol extract of &lt;em&gt;Gardenia augusta&lt;/em&gt; (L.) Merr. flowers in rat model. &lt;strong&gt;Methods: &lt;/strong&gt;Rats were assigned into group receiving the extract (at 0.9 or 1.8 g/kg), the reference drug crocetin (at 0.9 mg/kg) or vehicle, once a day orally for 15 days. &lt;strong&gt;Results: &lt;/strong&gt;Tested on day 1 and 14 of treatment, the rats receiving 1.8 g/kg of the extract showed improvements in sleep latency, sleep duration, sleep efficiency, wake episodes, and sleep cycle, which were significantly different from crocetin. Furthermore, tested on day 2 and 15 of treatment, the rats treated with 1.8 g/kg extract demonstrated superior sedative rating scale compared to crocetin. &lt;strong&gt;Conclusions: &lt;/strong&gt;Results of the present study indicates the potential of Gardenia augusta (L.) Merr. flower extract to be used as an adjunct treatment for sleep disorder.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1449</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusnandar Anggadiredja*, I Ketut Adnyana, Dewi Safitri, Siti Farah Rahmawati, Tomi Hendrayana&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacology and Clinical Pharmacy, School of Pharmacy Institut Teknologi Bandung, Jl. Ganesa 10 Bandung 40132, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nurul Qamariah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Study of Qur`an Plants</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethnobotanical study</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Qur`an plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">919-928</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; In Islam, ethical teachings of biomedical ethics are linked with a Holy Qur`an and Prophet Muhammad (PBUH). Al-Quran is one of the best reference books describing the importance of plants for medical benefits. There are 28 chapters (Surah) which mention specific name of plants in Al-Qur`an. This paper aims to compile the up-to-date information about some medicinal plants that mentioned in Al-Qur`an. &lt;strong&gt;Methods:&lt;/strong&gt; Comprehensive and detailed information about plants has been collected from Ayat and Surah in the Qur'an which states the specific name of the plant. Plant identities are arranged in a systematic sequence of confirmed botanical names from literature such as books, journal articles, and online databases, followed by Indonesian names, English names, families, references from the Qur'an, parts used, chemical content, And medicinal properties. The pharmacological claims of plants mentioned in the Qur'an, enriched by the search for scientific evidence available in journals and books. &lt;strong&gt;Results:&lt;/strong&gt; Based on the collected data, there are 27 plant species mentioned in Al-Qur`an. In this paper, plants species were arranged in a systematic order of identity of the plant, followed by Indonesian name, English name, Family, references cited from Holy Quran, Part used, Chemical constituents, and efficacy of herbal medicine that has been used both empirically and scientifically. &lt;strong&gt;Conclusion: &lt;/strong&gt;In this paper, attempts have been made to compile up-to-date knowledge of 27 species medicinal plants mentioned in the Qur'an, which can be used as a quick reference guide for further studies in ethnobotany.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">919</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nurul Qamariah*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Pharmacy Department, Faculty of Health Sciences, Universitas Muhammadiyah Palangkaraya, Palangka Raya, Central Kalimantan 73111, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fatima Senouci</style></author><author><style face="normal" font="default" size="100%">Adda Ababou</style></author><author><style face="normal" font="default" size="100%">Mohammed Chouieb</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Survey of the Medicinal Plants used in the Southern Mediterranean. Case Study: The Region of Bissa (Northeastern Dahra Mountains, Algeria)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Algeria</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Indigenous population</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">647-659</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The present study falls within the framework of valorization of medical plants and traditional knowledge’s in the Northeastern part of Dahra Mountain, Algeria. &lt;strong&gt;Methods:&lt;/strong&gt; An ethnobotanical survey was conducted between 2016 and 2018 in order to study the traditional and therapeutic use of medical plants amongst the local population. Data collected was analyzed using quantitative indices such as the Fidelity Level (FL) and Informant Consensus Factor (FIC). &lt;strong&gt;Results:&lt;/strong&gt; The results revealed 70 medicinal species belonging to 38 botanical families, among which, five families were the most commonly used by the local population, especially the families Lamiaceae and Asteraceae. In term of species, the highest frequencies of medicinal use were shown respectively by &lt;em&gt;Tetraclinis articulata&lt;/em&gt; (Vahl) Mast. (6.49%), &lt;em&gt;Pistacia lentiscus&lt;/em&gt; L. (6.11%), &lt;em&gt;Myrtus communis&lt;/em&gt; L. (5.34%) and &lt;em&gt;Thymus vulgaris&lt;/em&gt; L. (4.96%). Among the various parts of the plant, leaves were the most used part and decoction was the most frequent form of use. Finally, the gastro-intestinal system disorders were the most treated diseases with a percentage of 28.24%. &lt;strong&gt;Conclusion: &lt;/strong&gt;This first ethnobotanical study conducted in the region of Bissa revealed a very rich local knowledge in term of traditional herbal medicine; this fact was reflected by the high diversity of species used in the treatment of several diseases. In light of this, it is therefore very important to subject some of the major species to further phytochemical and pharmacological studies in order to validate their traditional use and to probably discover new bioactive molecules.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">647</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fatima Senouci&lt;sup&gt;1,2,*&lt;/sup&gt;, Adda Ababou&lt;sup&gt;2,3&lt;/sup&gt;, Mohammed Chouieb&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Nature and Life Sciences, University Abd El Hamid Ibn Badis, Mostaganem, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Natural Bioresources, Faculty of Nature and Life Sciences, University Hassiba Ben Bouali, Chlef, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Nature and Life Sciences, University Hassiba Ben Bouali, Chlef, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Agronomy, Faculty of Nature and Life Sciences, University Abd El Hamid Ibn Badis, Mostaganem, ALGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ghanashyam Mahato</style></author><author><style face="normal" font="default" size="100%">Bangamoti Hansda</style></author><author><style face="normal" font="default" size="100%">Nilanjana Banerjee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanicals used for the Treatment of Skin Diseases with Special Emphasis on Carbuncle Disease from Purulia District of West Bengal in India</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carbuncle</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Fidelity level</style></keyword><keyword><style  face="normal" font="default" size="100%">Informant consensus factor</style></keyword><keyword><style  face="normal" font="default" size="100%">Purulia</style></keyword><keyword><style  face="normal" font="default" size="100%">Use value</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">745-753</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;From time immemorial ethnic people of Purulia district of West Bengal are well acquainted with different plant resources for the treatment of various skin diseases including 'carbuncle' and others skin diseases. Carbuncle, caused by the methicillin resistant Staphylococcus aureus is of major concern in this part of India, mostly dominated by tribes like Majhi, Munda, Santal, Birhor, Ho and Rajwar etc. Hot climate, overcrowded households, improper sanitation, very poor economic background and frequent burn accidents are of major issues for spreading of these bacterial infections. &lt;strong&gt;Objective:&lt;/strong&gt; Present authors are trying to summarize these ethno-medicinal knowledge of the local, conservative traditional healers by using structured questionnaires given to them and are trying to analyze these information from scientific perspective. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Plant samples were collected from March 2014 to May 2016, mostly during their flowering stage and a total of 62 people, both male (84%) and female (16%) were interviewed. Informant consensus factor, fidelity level and use value were calculated. &lt;strong&gt;Results:&lt;/strong&gt; Fifty-nine herbal plants belongs to 35 families were recorded for the cure of various skin diseases, among which 10 plants are used individually during medication whereas 9 polyherbal formulations were used in various combinations during treatment. Five species of the families Moraceae and Asteraceae was found to be the most common medicinal plants, among which 44.89% are herbaceous in habit. Leaves (55.55%) are the most common plant part for their use. &lt;strong&gt;Conclusion: &lt;/strong&gt;Therefore, the present paper has been written to document this rapidly vanishing huge knowledge of folklore which should be digitally conserved for futuristic approach on medicinal plants in India.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">745</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ghanashyam Mahato&lt;sup&gt;1&lt;/sup&gt;, Bangamoti Hansda&lt;sup&gt;2&lt;/sup&gt;, Nilanjana Banerjee&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Assistant Professor, Department of Botany, A.M. College, Jhalda, Purulia, West Bengal-723202, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Scholar, Department of Botany and Forestry, Vidyasagar University, Midnapore, West Bengal-721102, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Botany, Vidyasagar University, Paschim Medinipur, West Bengal-721102, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rashmi Mallya</style></author><author><style face="normal" font="default" size="100%">Fehmina Malim</style></author><author><style face="normal" font="default" size="100%">Akanksha Naik</style></author><author><style face="normal" font="default" size="100%">Milind Bhitre</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anthelmintic Potential of Leaves and Fruits of Zanthoxylum rhetsa</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthelmintic</style></keyword><keyword><style  face="normal" font="default" size="100%">Fruit</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Zanthoxylum rhetsa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">475-478</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Zanthoxylum rhetsa&lt;/em&gt; of family Rutaceae is traditionally employed for treatment of intestinal worms, urinary tract infection, tooth ache, asthma, bronchitis and rheumatism. Thus, the objective of the study was to screen in vitro anthelmintic activity of leaves and fruits of &lt;em&gt;Zanthoxylum rhetsa&lt;/em&gt; on &lt;em&gt;Eisenia fetida&lt;/em&gt; and &lt;em&gt;Tubifex tubifex&lt;/em&gt;.&lt;strong&gt; Material and Methods:&lt;/strong&gt; Total methanol extract and solvent fractions of methanol extract were prepared by maceration and solvent solvent extraction process respectively. The chromatographic fingerprints of total methanol extracts of leaves and fruits were developed using HPTLC. &lt;strong&gt;Results:&lt;/strong&gt; The leaf and fruit extracts showed the presence of alkaloids, flavonoids, terpenoids, coumarins, essential oils and saponins. The extracts exhibited significant anthelmintic activity as evidenced by decrease in paralysis death time in the treatment groups when compared to standard. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results suggest that fruits and leaves of &lt;em&gt;Z rhetsa&lt;/em&gt; have promising anthelmintic activity and further studies are required to identify the phytochemicals responsible for anthelmintic activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">475</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rashmi Mallya&lt;sup&gt;1,2,*&lt;/sup&gt;, Fehmina Malim&lt;sup&gt;1&lt;/sup&gt;, Akanksha Naik&lt;sup&gt;1&lt;/sup&gt;, Milind Bhitre&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2&lt;/strong&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Gate No:1 Mithibai College Campus, Vile Parle (West), Mumbai–400052, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;C.U. Shah College of Pharmacy, SNDT Women’s University, Santacruz (West), Mumbai–400049, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paavai Ilango</style></author><author><style face="normal" font="default" size="100%">Vasugi Suresh</style></author><author><style face="normal" font="default" size="100%">Ayswarya V Vummidi1</style></author><author><style face="normal" font="default" size="100%">Vanessa Ravel</style></author><author><style face="normal" font="default" size="100%">Veejai Chandran</style></author><author><style face="normal" font="default" size="100%">Arulpari Mahalingam</style></author><author><style face="normal" font="default" size="100%">Vineela Katam Reddy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antibacterial Activity of Lemongrass Oil Against Oral Clinical Isolates – An In vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Lemongrass essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Minimal inhibitory Concentration</style></keyword><keyword><style  face="normal" font="default" size="100%">Tetracycline</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1023-1028</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; There are 1,200 oral species out of which 400 are potentially important and 20 organisms are periopathic. Periodontal flora plays the important role in initiation and progression of periodontal diseases. There are various conservative and surgical procedures to treat and prevent periodontal diseases. Local drug delivery agents reduce microbial burden, blocks collagenase activity and inhibits bone loss; out of which tetracycline is common in use. Unwanted side effects and resistance of microorganisms towards antibiotics due to their widespread use have modified the general prescription about their efficacy. Various researches elucidate that herbal extracts exhibit wide range of antibacterial activity. In recent years, Lemongrass essential oil gains scientific interest as it targets even the periodontal pathogens. The purpose of this study is to comparatively evaluate the antibacterial activity of lemongrass essential oil with that of tetracycline. &lt;strong&gt;Aim and objective:&lt;/strong&gt; To comparatively evaluate the antibacterial activity of lemongrass essential oil with tetracycline against Streptococcus mutans, Staphylococcus epidermidis and Lactobacillus and to determine the minimal inhibitory concentration of lemongrass essential oil. &lt;strong&gt;Study design:&lt;/strong&gt;&lt;em&gt; In vitro&lt;/em&gt;.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; It is an&lt;em&gt; in vitro&lt;/em&gt; study done to demonstrate the antimicrobial activity of lemongrass against the oral microbes. Based on their involvement in various clinical conditions Streptococcus mutans, Staphylococcus epidermidis and Lactobacillus were selected for the study. These organisms were inoculated to a solid media and incubated overnight aerobically at 37°C to obtain a pure culture. The culture was made as a suspension in sterile saline with the turbidity matching 0.5 Macfarland standard. This is used to make a lawn culture on the Mueller Hinton Agar. Antimicrobial effect of tetracycline was tested using standard disc of doxycycline 30 mcg (Himedia, SD012) and sterile disc was used to prepare lemongrass essential oil which contained 10 μl, 15 μl and 20μl. In each category 5 discs were tested to get a mean zone of inhibition. After 24 hours of incubation the zone of inhibition was measure in mm using a scale. The measured zone size was tabulated and compared among the groups. &lt;strong&gt;Results: &lt;/strong&gt;The minimal inhibitory concentration of lemon grass essential oil was estimated to be 10μl. Statistically significant zone of inhibition and antibacterial zone was greater in lemongrass essential oil than tetracycline for Streptococcus mutans and Staphylococcus epidermis. &lt;strong&gt;Conclusion: &lt;/strong&gt;Lemongrass essential oil showed higher antibacterial activity than tetracycline. Hence, it can be used as a good alternative to tetracycline or adjunctive in the treatment of periodontitis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1023</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paavai Ilango&lt;sup&gt;1&lt;/sup&gt;, Vasugi Suresh&lt;sup&gt;2&lt;/sup&gt;, Ayswarya V Vummidi&lt;sup&gt;1&lt;/sup&gt;, Vanessa Ravel&lt;sup&gt;1&lt;/sup&gt;, Veejai Chandran&lt;sup&gt;1&lt;/sup&gt;, Arulpari Mahalingam&lt;sup&gt;3&lt;/sup&gt;, Vineela Katam Reddy&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Periodontics, Priyadarshini Dental College &amp;amp; Hospital, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physiology, Priyadarshini Dental College &amp;amp; Hospital, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pedodontics, Thai Moogambigai Dental College &amp;amp; Hospital, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of periodontics, Indira Gandhi Institute of Dental Sciences, Puducherry, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kishor Mazumder</style></author><author><style face="normal" font="default" size="100%">Ziku Chandra Dey</style></author><author><style face="normal" font="default" size="100%">Suparna Dey</style></author><author><style face="normal" font="default" size="100%">Md. Fazlul Kabir</style></author><author><style face="normal" font="default" size="100%">Minhazur Rahman</style></author><author><style face="normal" font="default" size="100%">Sadiur Rahman Sajon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti-diarrheal and Anti-nociceptive Activity of Methanolic Unripe Fruit Peels Extract of Masua ferrea Linn. on Mice Models</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diarrheal</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-nociceptive</style></keyword><keyword><style  face="normal" font="default" size="100%">Castor oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Intestinal transit</style></keyword><keyword><style  face="normal" font="default" size="100%">Mesua ferrea</style></keyword><keyword><style  face="normal" font="default" size="100%">Tail immersion method</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">828-835</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Though traditionally the plant &lt;em&gt;Masua ferrea &lt;/em&gt;has been used by south east Asian people in inflammation and septic conditions, the present study was designed to investigate the anti-diarrheal and anti-nociceptive activities of unripe fruit peel of &lt;em&gt;Mesua ferrea&lt;/em&gt; on animal models. &lt;strong&gt;Methods:&lt;/strong&gt; Various methods were employed for investigating these activities such as castor-oil induced diarrhea, castor-oil induced enteropooling and gastrointestinal motility test, acetic acid induced writhing test, tail immersion and hot plate methods. &lt;strong&gt;Results: &lt;/strong&gt;From the experimental data it was found that the diarrheal episode was inhibited by 39.68% and 49.21% for methanol extract at the doses of 100 and 200 mg/kg respectively. The extract significantly lessened the intestinal volume for methanolic extract at 200 mg/Kg dose 0.54 ± 0.01 ml (&lt;em&gt;p &lt;/em&gt;&amp;lt; 0.05) and at 200 mg/Kg dose 0.47 ± 0.02 ml (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.01) compared to control 0.65 ± 0.03 ml in castor-oil induced enteropooling and also decreased intestinal transit 29.07 – 48.54% for methanolic extract comparable with standard (loperamide 5 mg/kg). &lt;em&gt;Mesua ferrea&lt;/em&gt; peels significantly (&lt;em&gt;P&lt;/em&gt; &amp;lt; 0.05, &lt;em&gt;P&lt;/em&gt; &amp;lt; 0.01 and &lt;em&gt;P&lt;/em&gt; &amp;lt; 0.001) reduced the number of writhing, increased latency to flick tail in tail immersion method and elevated the mean basal reaction time in hot plate method respectively. Besides, no delayed toxicity was observed in given doses. &lt;strong&gt;Conclusion:&lt;/strong&gt; The methanolic extract exhibited highly significant anti-diarrheal and antinociceptive activity in a dose-dependent manner, which supports its use in traditional herbal medicine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">828</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kishor Mazumder&lt;sup&gt;1,3,*&lt;/sup&gt;, Ziku Chandra Dey&lt;sup&gt;2&lt;/sup&gt;, Suparna Dey&lt;sup&gt;4&lt;/sup&gt;, Md. Fazlul Kabir&lt;sup&gt;2&lt;/sup&gt;, Minhazur Rahman&lt;sup&gt;2&lt;/sup&gt;, Saidur Rahaman sajon&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Jessore University of Science and Technology, Jessore-7408, Jessore, BANGLADESH.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;University of Science and Technology Chittagong (USTC), Chittagong, BANGLADESH.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Biomedical Sciences and Graham Centre for Agricultural Innovation, Charles Sturt University, Boorooma St, Wagga Wagga, NSW, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Center for Specialized Care and Research, Chittagong-4000, BANGLADESH.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jamiuddin Ahmed</style></author><author><style face="normal" font="default" size="100%">Kamariah Abu Salim</style></author><author><style face="normal" font="default" size="100%">Linda B.L. Lim</style></author><author><style face="normal" font="default" size="100%">Abdalla Mohamed Jama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antioxidant Activity and Phytochemical Screening of Leaves, Barks, Stems and Fruits of Alphitonia philippinensis (Rhamnaceae) From Brunei Darussalam</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant property</style></keyword><keyword><style  face="normal" font="default" size="100%">philippinensis</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical investigation</style></keyword><keyword><style  face="normal" font="default" size="100%">Total Phenolic Contents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">951-961</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Phytochemical screening of Alphitonia philippinensis extracts revealed the presence of cardiac glycosides, tannins, saponins and steroids in different plant parts. Total phenolic content (TPC), total flavonoid content (TFC) and total flavonol content (TFlC) were measured using spectrophotometric methods where gallic acid and quercetin were the standards. Antioxidant activity of extracts was assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2̉-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid) (ABTS), free radical scavenging and ferric reducing antioxidant power (FRAP) assays using ascorbic acid and trolox were used as standards. Among the four different crude methanol extracts studies, leaves showed highest antioxidant capacity. EC&lt;sub&gt;50&lt;/sub&gt; values of the leaves extract from DPPH and ABTS method found 32 and 45 μg/mL respectively. The higher antioxidant activity of the leaves extract could be correlated with the presence of higher total phenolic content, total flavonoid, and total flavonol contents. According to antioxidant contents and assay results leaves extract possesses highest antioxidant property following fruits, barks and stems.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">951</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Jamiuddin Ahmed&lt;sup&gt;1,3&lt;/sup&gt;,*, Kamariah Abu Salim&lt;sup&gt;1&lt;/sup&gt;, Linda B.L. Lim&lt;sup&gt;2&lt;/sup&gt;, Abdalla Mohamed Jama&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Environmental and Life Sciences, Faculty of Science, Universiti Brunei Darussalam, Tungku Link Road, Bandar Seri Begawan BE 1410, BRUNEI DARUSSALAM.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Chemical Sciences, Faculty of Science, Universiti Brunei Darussalam, Tungku Link Road, Bandar Seri Begawan BE 1410, BRUNEI DARUSSALAM.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Noakhali Science and Technology University, BANGLADESH.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amrita Pal</style></author><author><style face="normal" font="default" size="100%">Anirban Chouni</style></author><author><style face="normal" font="default" size="100%">Arpan Das</style></author><author><style face="normal" font="default" size="100%">Ribhu Ray</style></author><author><style face="normal" font="default" size="100%">Santanu Paul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti-proliferative Potential and Antioxidant Activity of a Wild Edible Mushroom Macrocybe crassa (Sacc.) Pegler and Lodge</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Macrocybe crassa</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF7</style></keyword><keyword><style  face="normal" font="default" size="100%">MOLT-4</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1504-1510</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study aims to quantify the anti-oxidant activity of the methanolic extract of &lt;em&gt;Macrocybe crassa &lt;/em&gt;and its anti-proliferative activity on normal and cancer cells. &lt;strong&gt;Methods:&lt;/strong&gt; The anti-oxidant potential of the extract was determined by several&lt;em&gt; in vitro&lt;/em&gt; assay system like DPPH radical scavenging activity, superoxide anion scavenging activity, percentage inhibition of lipid peroxidation and nitric oxide (NO) scavenging activity. Anti-proliferative activity was tested by MTT assay on breast cancer cell line MCF7, Human acute T lymphoblastic leukaemic cell MOLT-4 and Peripheral Blood Mononuclear Cells or PBMC isolated from a healthy donor to check its cytotoxic effect on normal cells. &lt;strong&gt;Results: &lt;/strong&gt;Results indicated that the methanolic extract of &lt;em&gt;Macrocybe crassa&lt;/em&gt; shows appreciable anti-proliferative activity against breast cancer cell line MCF7 and negligible effect on MOLT4 cells. In contrast no significant anti-proliferative effect has been observed in normal PMMCs. Moderate anti-oxidant activity was recorded in methanolic extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; Methanolic extract of of &lt;em&gt;Macrocybe crassa&lt;/em&gt; with moderate anti-oxidant activity and specific anti-proliferative effect on MCF7 holds a great promise can be used for isolation of bio molecules for treating Breast Cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1504</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amrita Pal, Anirban Chouni, Arpan Das, Ribhu Ray, Santanu Paul* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Laboratory of Cell and Molecular Biology, Department of Botany, University of Calcutta, Kolkata 700019, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Janani Jacob</style></author><author><style face="normal" font="default" size="100%">Gopalan R</style></author><author><style face="normal" font="default" size="100%">Lakshmanaperumalsamy P</style></author><author><style face="normal" font="default" size="100%">Ramanaiah Illuri</style></author><author><style face="normal" font="default" size="100%">Damaji Bhosle</style></author><author><style face="normal" font="default" size="100%">Gopala Krishna Sangli</style></author><author><style face="normal" font="default" size="100%">Deepak Mundkinajeddu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti-psoriatic Potential of the Fruit Rind of Punica granatum L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-psoriatic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Punica granatum</style></keyword><keyword><style  face="normal" font="default" size="100%">Thymidine phosphorylase inhibition</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">466-468</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Pomegranate (&lt;em&gt;Punica granatum L.&lt;/em&gt;) is universally known for its therapeutic properties due to its potential bioactive compounds. However, there is no established scientific study on antipsoriatic activity of pomegranate fruit rind. The aim of the study is to evaluate the anti-psoriatic activity of the isolated compounds and the extract from the fruit rind of &lt;em&gt;P. granatum.&lt;/em&gt; In our previous study, the isolated compounds were evaluated for antioxidant potential. In continuation to the previous investigation, the present study is taken up to evaluate the extract and compounds for &lt;em&gt;in vitro&lt;/em&gt; anti-psoriatic activity. &lt;strong&gt;Methods:&lt;/strong&gt; Chromatographic techniques were employed to isolate the compounds from the aqueous acetone extract and&lt;em&gt; in vitro &lt;/em&gt;anti-psoriatic activity was determined by thymidine phosphorylase inhibition assay. &lt;strong&gt;Results: &lt;/strong&gt;From previous phytochemical investigation, three compounds were identified as Punicalagin, 2,3(&lt;em&gt;S&lt;/em&gt;)-hexahydroxydiphenoyl-D-glucose and Punicalin. In the present study, the extract and the compounds were evaluated for anti-psoriatic activity. The results reveal that the isolated three compounds showed inhibitory activity of 89% to 95% against thymidine phosphorylase. Aqueous acetone extract also exhibited 87% inhibition. &lt;strong&gt;Conclusion: &lt;/strong&gt;&lt;em&gt;Punica granatum&lt;/em&gt; is an ideal plant for further investigation to prove its anti-psoriatic activity.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&amp;nbsp;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">466</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Janani Jacob&lt;sup&gt;1,2*&lt;/sup&gt;, Gopalan R&lt;sup&gt;3&lt;/sup&gt; Lakshmanaperumalsamy P&lt;sup&gt;4&lt;/sup&gt;, Ramanaiah Illuri&lt;sup&gt;2&lt;/sup&gt;, Damaji Bhosle&lt;sup&gt;2&lt;/sup&gt;, Gopala Krishna Sangli&lt;sup&gt;2&lt;/sup&gt;, Deepak M&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Karpagam Academy of Higher Education, Coimbatore- 641021, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;R and&amp;nbsp;D Centre, Natural Remedies Pvt. Ltd. Bangalore-560 100, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Botany, Karpagam Academy of Higher Education, Coimbatore- 641021, Tamil Nadu INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Environmental Sciences, Bharathiar University, Coimbatore- 641 046, Tamil Nadu INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lubna F. Abu-Niaaj</style></author><author><style face="normal" font="default" size="100%">Ibrahim Katampe</style></author><author><style face="normal" font="default" size="100%">Shtaywy S. Abdalla</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antispasmodic Effect of Arcapillin on Smooth Muscles of Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antispasmodic</style></keyword><keyword><style  face="normal" font="default" size="100%">Arcapillin</style></keyword><keyword><style  face="normal" font="default" size="100%">Artemisia monosperma</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavone</style></keyword><keyword><style  face="normal" font="default" size="100%">Smooth Muscles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">712-717</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Arcapillin, 2',4',5-trihydroxy-5',6,7–trimethoxyflavone, is a flavone aglycone isolated from several &lt;em&gt;Artemisia&lt;/em&gt; species, though, it was first identified from &lt;em&gt;A. capillaris&lt;/em&gt;. The &lt;em&gt;Artemisia&lt;/em&gt; species are used in folk medicine as a remedy for gastrointestinal and liver illnesses, hypertension, fever and inflammation. Studies indicated a potential role of arcapillin to relieve symptoms of liver disorders; however, there is no report yet in the literature of its effect on smooth muscles. &lt;strong&gt;Objective:&lt;/strong&gt; Our study aims to evaluate the effect of arcapillin, isolated from &lt;em&gt;A. monosperma&lt;/em&gt;, on the contractile activity of rat smooth muscles. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Increased concentrations of arcapillin were tested on isolated rat ileum, pulmonary artery, trachea, and urinary bladder. The muscle contraction was recorded upon addition of arcapillin in eight cumulative concentrations of half log units in the range of [10&lt;sup&gt;-7&lt;/sup&gt; M -3×10&lt;sup&gt;-4 &lt;/sup&gt;M]. Depending on the organ-containing muscles, the preparations were treated with arcapillin either at basal tonus or after pre-stimulated via a contractile agent; 10&lt;sup&gt;-3&lt;/sup&gt; M O-acetylcholine on ileum and 10&lt;sup&gt;-5&lt;/sup&gt; M L-phenylephrine on pulmonary artery rings. Control tissues were treated with sodium hydroxide in an equivalent concentration to that used to dissolve the flavone. &lt;strong&gt;Results:&lt;/strong&gt; Arcapillin caused a dose-dependent relaxation on ileum preparation and pulmonary artery. The inhibition of the contractile activity of ileum was reversible within 60 seconds after washing off the flavone. The urinary bladder showed a slight increase in contraction at the highest concentrations starting at [10&lt;sup&gt;-4 &lt;/sup&gt;M] of arcapillin. There was no observed effect on the contraction of tracheal smooth muscles by all tested concentrations of arcapillin. &lt;strong&gt;Conclusion:&lt;/strong&gt; The antispasmodic activity of arcapillin may contribute to the pharmaceutical importance of &lt;em&gt;A. monosperma &lt;/em&gt;in particularly to treat gastrointestinal disorders.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">712</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lubna F. Abu-Niaaj&lt;sup&gt;1,*&lt;/sup&gt;, Ibrahim Katampe&lt;sup&gt;1&lt;/sup&gt;, Shtaywy S. Abdalla&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Agricultural and Life Sciences, Central State University, Wilberforce, OH 45384, USA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biological Sciences, University of Jordan, Amman, JORDAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdul Gofur</style></author><author><style face="normal" font="default" size="100%">Agung Witjoro</style></author><author><style face="normal" font="default" size="100%">Erni Widya Ningtiyas</style></author><author><style face="normal" font="default" size="100%">Evi Setyowati</style></author><author><style face="normal" font="default" size="100%">Siti Aminatul Mukharromah</style></author><author><style face="normal" font="default" size="100%">Mochammad Fitri Atho’illah</style></author><author><style face="normal" font="default" size="100%">Sri Rahayu Lestari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Evaluation of Dietary Black Soybean and Purple Sweet Potato on Insulin Sensitivity in Streptozotocin - Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Malondialdehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Necrosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxide dismutase</style></keyword><keyword><style  face="normal" font="default" size="100%">T2DM</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">639-646</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Hyperglycemia mediates the production of excess free radicals and reduces endogenous antioxidant in type 2 diabetes mellitus (T2DM). Black soybean (BSB) is rich in antioxidant mainly from isoflavones, whereas the antioxidant of purple sweet potato (PSP) comes from high anthocyanin. The study aimed to evaluate the efficacy of BSB, PSP, and its combination on malondialdehyde (MDA), superoxide dismutase (SOD) concentrations, insulin and insulin receptor substrate-1 (IRS-1) expression in T2DM rats. &lt;strong&gt;Methods: &lt;/strong&gt;T2DM induced by high-calorie diet for five weeks and then injected with a low dose of streptozotocin (30 mg/kg BW) intraperitoneally. The DM rats then treated with black soybean (DM + BSB), purple sweet potato (DM + PSP) and the combination of BSB and PSP 1:3, 2:2, 3:1 respectively (DM + C1- 3). Treatments were given for thirty days. The effect of BSB, PSP and its combination evaluated by measuring SOD and MDA, necrosis in pancreas evaluated through hematoxylin-eosin (HE) and insulin and IRS-1 expression in pancreas through immunohistochemistry-fluorescence (IHC-F). &lt;strong&gt;Results: &lt;/strong&gt;Our result indicated that there were no significant differences of BSB and the combination in decreasing MDA concentrations. The ratio of BSB and PSP combination of 2:2 increase SOD towards near normal, decrease necrosis, and improve insulin and IRS-1. &lt;strong&gt;Conclusion: &lt;/strong&gt;The combination of BSB and PSP had the potential to improve insulin sensitivity through the increase of SOD, reduce necrosis, and improve insulin and IRS-1 expression.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">639</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abdul Gofur&lt;sup&gt;1,*&lt;/sup&gt;, Agung Witjoro&lt;sup&gt;1&lt;/sup&gt;, Erni Widya Ningtiyas&lt;sup&gt;1&lt;/sup&gt;, Evi Setyowati&lt;sup&gt;1&lt;/sup&gt;, Siti Aminatul Mukharromah&lt;sup&gt;1&lt;/sup&gt;, Mochammad Fitri Atho’illah&lt;sup&gt;2&lt;/sup&gt;, Sri Rahayu Lestari&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Science, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Science, Brawijaya University, Jl. Veteran, Malang 65145, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Puneshwar Keshari</style></author><author><style face="normal" font="default" size="100%">Pradeep</style></author><author><style face="normal" font="default" size="100%">Sudhakar Bhat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Hepatoprotective Potential of Rhododendron arboreum Sm. Stem Bark as Abhava Pratinidhi Dravya (Substitute) of Rohitaka (Tecomella undulata (Sm.) Seem.) Against Paracetamol Induced Hepatotoxicity in Experimental Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Abhava Pratinidhi Dravya</style></keyword><keyword><style  face="normal" font="default" size="100%">Choorna</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Kwatha</style></keyword><keyword><style  face="normal" font="default" size="100%">Rhododendron arboreum</style></keyword><keyword><style  face="normal" font="default" size="100%">Rohitaka</style></keyword><keyword><style  face="normal" font="default" size="100%">Substitute</style></keyword><keyword><style  face="normal" font="default" size="100%">Tecomella undulata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1148-1154</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Rohitaka (&lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem.) has been considered as threatened and listed as rare at international level (IUCN, 2000). In Ayurveda classics, Rohitaka is described as Yakritpleehgulmodarhara (useful in liver and spleenic disorders). &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. is used by folklore practitioners for treatment of Jaundice and marketed as Rohitaka in Nepal. &lt;strong&gt;Aim: &lt;/strong&gt;To evaluate &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. as an effective pratinidhi dravya (substitute) in abhava (absence) of Rohitaka (&lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem.) with special reference to hepatoprotective activity in paracetamol induced hepatotoxicity in rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; In the present study, hepatoprotective effect of Choorna (powder) and Kwatha (decoction) of &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. and &lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem. (Choorna-0.54 g/kg body wt. and Kwatha- 4.32 ml/kg body wt. p. o. for 10 days along with paracetamol toxicant 3 g/kg body wt. p. o. on 6&lt;sup&gt;th&lt;/sup&gt; and 8&lt;sup&gt;th &lt;/sup&gt;day) were investigated against paracetamol induced hepatotoxicity. Silymarin (100 mg/kg body wt.) was used as standard hepatoprotective reference drug. &lt;strong&gt;Statistical Analysis Used:&lt;/strong&gt; The obtained data were analyzed by ANOVA with Dunnet's multiple ‘t’ test and level of p&amp;lt;0.05 was considered as statistically significant. &lt;strong&gt;Results: &lt;/strong&gt;Paracetamol treatment led to elevated levels of liver marker enzymes and disorientation in histological observations which were significantly reversed by treatment with &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. and &lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem. dependent on dosage forms. &lt;strong&gt;Conclusion: &lt;/strong&gt;The study revealed that both the drugs have similar hepatoprotective effect and thus &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. as “Abhava Pratinidhi Dravya” for &lt;em&gt;Tecomella undulata&lt;/em&gt; (Sm.) Seem. with special reference to hepatoprotective activity is justified.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1148</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Puneshwar Keshari*, Pradeep, Sudhakar Bhat &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Dravyaguna, SDM College of Ayurveda and Hospital, Hassan- 573201, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Howaida I Abd-Alla</style></author><author><style face="normal" font="default" size="100%">Heba-tollah M Sweelam</style></author><author><style face="normal" font="default" size="100%">Walaa A El-Kashak</style></author><author><style face="normal" font="default" size="100%">Mounir M El-Safty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Immune Boosting Properties and Combating of Multiple Respiratory Viral Infections by fifteen Euphorbiaceae Plant Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Euphorbiaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">GC/MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemagglutination</style></keyword><keyword><style  face="normal" font="default" size="100%">Immune</style></keyword><keyword><style  face="normal" font="default" size="100%">Respiratory viral infections</style></keyword><keyword><style  face="normal" font="default" size="100%">SPF-ECEs</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1490-1503</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Fifteen Euphorbiaceae plant extracts were evaluated for their antiviral and immune boosting properties. &lt;strong&gt;Methods:&lt;/strong&gt; The maximum non-toxic concentration of each extract in specific pathogen–free embryonated chicken eggs was estimated and their antiviral efficacy was determined in terms of reduction in viral titers, measured by the hemagglutination inhibition (HI) assay. The antiviral efficacy was compared with ribavirin. The active extract was further subjected to estimation of total polyphenolic and flavonoid contents. Also, GC/ MS analysis was used to analyze its unsaponifiable and saponifiable matters. &lt;strong&gt;Results: &lt;/strong&gt;The cytotoxic concentration fifty (CC&lt;sub&gt;50&lt;/sub&gt;) of &lt;em&gt;Breynia distacha&lt;/em&gt; recorded the value of &amp;gt;200 and &amp;gt;300 for Newcastle disease virus (NDV) and avian influenza virus (AIV) H5N1, respectively. This extract showed antiviral inhibition concentration (IC&lt;sub&gt;50&lt;/sub&gt;) values of ≤ 2 and ≤ 3, respectively and antiviral therapeutic index of 100% compared with ribavirin as standard. The serum of the vaccinated chicks treated with &lt;em&gt;B. distacha &lt;/em&gt;has recorded the highest HI titers (7.1 and 8.3 log2) at the day of 28 post vaccination with high protection percentage (100 and 90%) post NDV and AIV H5N1 challenge, respectively. Also, a high HI titer (6.9 log2) was recorded in serum of the vaccinated chicks treated with &lt;em&gt;Aleurites moluccana, Jatropha curcas, Ricinus communis, Putranjiva roxburghii &lt;/em&gt;with protection percentage of 95-100% post-NDV challenge. GC/MS analysis allowed identification of 91.10% of the total unsaponifiable matter, (1-heptatriacotanol represented the major component, 24.61%) and 82.51% of the fatty acid methyl esters content (methyl palmitate represented the major component, 26.13 %). &lt;strong&gt;Conclusion:&lt;/strong&gt; This study highlighted the potential of many Euphorbiaceae plants especially&lt;em&gt; B. distacha,&lt;/em&gt; to be new candidate of plant-based prototypes that carry antiviral and immunogenic features against respiratory viral infections.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1490</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Howaida I. Abd-Alla&lt;sup&gt;1,&lt;/sup&gt;*, Hebatollah M. Sweelam&lt;sup&gt;1&lt;/sup&gt;, Walaa A. El-Kashak&lt;sup&gt;1&lt;/sup&gt;, Mounir M. El-Safty&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Chemistry of Natural Compounds Department, National Research Centre, El- Tahrir Street, Dokki, Giza 12622, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Quality Control of SPF Eggs Department, Central Laboratory for Evaluation of Veterinary Biologics, Abbassia 13181, Cairo, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vigasini Subbiah</style></author><author><style face="normal" font="default" size="100%">Pannaga Nagaraja</style></author><author><style face="normal" font="default" size="100%">Priya Narayan</style></author><author><style face="normal" font="default" size="100%">Holenarasipur GunduRao Nagendra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Pharmacological Properties of Caesalpinia bonducella Seed and Shell Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-mitotic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Caesalpinia bonducella</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January-2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">150-154</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt;&lt;em&gt; Caesalpinia bonducella&lt;/em&gt; L. is a medicinal plant belonging to the family Caesalpiniaceae. It is a prickly shrub widely distributed all over the world especially in Indian tropical regions such as Kerala, Andaman and Nicobar Islands and Sri Lanka. There are claims that its leaves or seeds/ seed kernel possess antipyretic, antidiuretic, antibacterial, antiviral, antiestrogenic and antidiabetic activities Due to the above properties several preparations of the plant were used in folk medicine.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The aqueous extract of &lt;em&gt;Caesalpinia bonducella&lt;/em&gt; nut containing the seed and the shell, has been evaluated for qualitative analysis of secondary metabolites (tannis, flavonoids, alkaloids, saponins, coumarins, quinone and phenols), in-vitro anti -inflammatory, anti-diabetic assay, antioxidant, antimitotic and antimicrobial activity. The studies were carried out using HRBC membrane stabilization, inhibition of alpha amalyse enzyme, DPPH method, green gram growth inhibition, agar diffusion method respectively. &lt;strong&gt;Results:&lt;/strong&gt; Our results indicate the presence of Alkaloids, Flavanoids and Saponins. We report in our study the antidiabetic, anti-inflammatory, anti-oxidant, anti-microbial and antimitotic activity of &lt;em&gt;Caesalpinia bonducella.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Vigasini Subbiah, Pannaga Nagaraja, Priya Narayan&lt;sup&gt;*&lt;/sup&gt;, Holenarasipur GunduRao Nagendra &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Biotechnology, Sir M Visvesvaraya Institute of Technology, Hunasamaranahalli, Bangalore- 562 157, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Astha Pandey</style></author><author><style face="normal" font="default" size="100%">Shalvi Agrawal</style></author><author><style face="normal" font="default" size="100%">Amruta D Patel</style></author><author><style face="normal" font="default" size="100%">Dushyant Pendarkar</style></author><author><style face="normal" font="default" size="100%">Jalpa D Bambhaniya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evergreen Conventional and Modern Microscopic Methods for Solving Various Cases of Forensic Botany by Morphological and Histological Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Botanical evidences</style></keyword><keyword><style  face="normal" font="default" size="100%">Cannabis sativa</style></keyword><keyword><style  face="normal" font="default" size="100%">Papaver somniferum</style></keyword><keyword><style  face="normal" font="default" size="100%">Ricinus communis</style></keyword><keyword><style  face="normal" font="default" size="100%">Scanning electron microscope</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">171-176</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The study concerning forensic evidences commences from the physical examination. Microscopic examination serves a good preliminary technique and provides a relatively quick and non-destructive means of obtaining qualitative information without much sample preparation. Various plants or plant materials such as pollens at the crime scene or a rare plant type present near a murder victim can be helpful in connecting suspect to a victim or scene. For examination of such evidences, the initial step is the identification of collected botanical evidences. Scanning electron microscope (SEM) produces images that rely on secondary electrons image and is concerned primarily with the observation of surface topography. SEM images at all direction (X-Y-Z rotation) giving a three dimensional view of the sample under study. &lt;strong&gt;Methods:&lt;/strong&gt; For morphological and histological examination, compound microscope and SEM has been used. Three plant specimens have been taken i.e. &lt;em&gt;Cannabis sativa&lt;/em&gt;,&lt;em&gt; Ricinus communis&lt;/em&gt; and &lt;em&gt;Papaver somniferum&lt;/em&gt;. For compound microscopic examination, sample has been stained with saffranin dye and for SEM examination; sample surface has been coated with gold-palladium layer to make it conductive.&lt;strong&gt; Results:&lt;/strong&gt; The morphological and histological examination by compound microscope and SEM revealed many characteristic features like ellipsoidal pollens in &lt;em&gt;Ricinus&lt;/em&gt;, cystolythic trichomes in &lt;em&gt;Cannabis&lt;/em&gt;, large oval stomata in poppy, etc. &lt;strong&gt;Conclusion:&lt;/strong&gt; The microscopic examination of botanical evidences by such sophisticated technique like SEM holds a lot of scope in forensic investigations with minimal evidence destruction and maximum details can be obtained in a preliminary examination only without using other complicated techniques.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">171</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Astha Pandey&lt;sup&gt;1,&lt;/sup&gt;*, Shalvi Agrawal&lt;sup&gt;2&lt;/sup&gt;, Amruta D Patel&lt;sup&gt;2&lt;/sup&gt;, Dushyant Pendarkar&lt;sup&gt;2&lt;/sup&gt;, Jalpa D Bambhaniya&lt;sup&gt;2&lt;/sup&gt;. &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Assistant Professor, Institute of Forensic Science Gujarat Forensic Sciences University Sector 9, near DFS office, Gandhinagar 382009- Gujarat, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Research Scholar, Institute of Forensic Science, Gujarat Forensic Sciences University, Gujarat, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">D.Sivaraman</style></author><author><style face="normal" font="default" size="100%">N.Anbu</style></author><author><style face="normal" font="default" size="100%">N.Kabilan</style></author><author><style face="normal" font="default" size="100%">M.Pitchiah Kumar</style></author><author><style face="normal" font="default" size="100%">P.Shanmugapriya</style></author><author><style face="normal" font="default" size="100%">G.J.Christian</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Exploration of Anti-Urolithiasis Potential of Traditional Siddha Formulations Amukkara Chooranam and Karisalai Karpam Chooranam by Struvite Crystal Growth Inhibition Assay</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amukkara Chooranam</style></keyword><keyword><style  face="normal" font="default" size="100%">Crystals</style></keyword><keyword><style  face="normal" font="default" size="100%">Karisalai karpam chooranam</style></keyword><keyword><style  face="normal" font="default" size="100%">Lithotripsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyherbal</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicines</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">683-688</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Urolithiasis is a medical condition characterized by formation of stone which comprises of calcium oxalate, magnesium ammonium phosphate and uric acid. Reoccurrence becomes the primary hindering factor in providing relief for urolithiasis; hence there is a need of alternate therapeutic strategy that may effectively combat and halt the formation and nucleation of the crystals. &lt;strong&gt;Objective: &lt;/strong&gt;The main aim of the present investigation is to explore the anti-urolithiasis potential of the two versatile siddha formulations Amukkara Chooranam (AKC) and Karisalai Karpam Chooranam (KKC) using diffusion gel growth technique. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Silica hydrogel matrix was divided in to three groups which were control, AKC and KKC treated groups. Test drugs were screened at two dose levels of 0.5% and 1%. The efficiency of the formulations was screened by comparing the crystal size of the control and treatment medium. &lt;strong&gt;Results: &lt;/strong&gt;The average size of the crystals in the control medium was found to be 2.12 ± 0.22 cm, whereas the crystal size was significantly decreased in medium contains 0.5% and 1% of AKC with the size of 1.4 ± 0.15 and 1.14 ± 0.18 cm. Similar type of findings were observed in medium consist of 0.5% and 1 % KKC with the size of 1.52 ± 0.13 and 1.08 ± 0.17 cm. &lt;strong&gt;Conclusion: &lt;/strong&gt;Results clearly indicates that both the siddha formulations offers maximum percentage inhibition on the crystal growth in the tested medium, this efficacy may be due to presence of versatile phytocomponents present in the formulations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">683</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;D.Sivaraman&lt;sup&gt;1,&lt;/sup&gt;*, N.Anbu&lt;sup&gt;2&lt;/sup&gt;, N.Kabilan&lt;sup&gt;3&lt;/sup&gt;, M.Pitchiah Kumar&lt;sup&gt;4&lt;/sup&gt;, P.Shanmugapriya&lt;sup&gt;5&lt;/sup&gt;, G.J.Christian&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centre for Laboratory Animal Technology and Research, Col.Dr.Jeppiaar Research Park, Sathyabama Institute of Science and Technology , Jeppiaar Nagar, Rajiv Gandhi road, Chennai – 600 119,Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pothu Maruthuvam, Govt. Siddha Medical College, Chennai-600106, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Siddha, The Tamil Nadu Dr.M.G.R. Medical University, Chennai - 600032, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;State Drug Licensing Authority (Indian System of Medicine), Arumbakkam, Chennai – 600106, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Nanjunoolum Maruthuva Neethi Noolum, National Institute of Siddha, Tambaram Sanatorium, Chennai-47, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Noi Naadal, National Institute of Siddha, Tambaram Sanatorium, Chennai-47, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Alya Jameel Ali Alsaad</style></author><author><style face="normal" font="default" size="100%">Ammar B. Altemimi</style></author><author><style face="normal" font="default" size="100%">Salah Naji Aziz</style></author><author><style face="normal" font="default" size="100%">Naoufal Lakhssassi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extraction and Identification of Cactus Opuntia dillenii Seed Oil and its added Value for Human Health Benefits</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cactus</style></keyword><keyword><style  face="normal" font="default" size="100%">Cake</style></keyword><keyword><style  face="normal" font="default" size="100%">Fatty Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Peroxide value</style></keyword><keyword><style  face="normal" font="default" size="100%">Seed-oil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">579-587</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Cactus &lt;em&gt;Opuntia dillenii&lt;/em&gt; presents multiple health benefits. The current study aims to investigate the seed composition and content of prickly pear fruits from Iraq. Results obtained showed that &lt;em&gt;Opuntia dillenii&lt;/em&gt; contained 9.5% of seeds of the entire fruit while extracted oil presented 6.5% of total seed composition. Fatty acid analysis revealed that the polyunsaturated linoleic acid (72.9%), the saturated palmitic acid (15.12%) and stearic acid (7.51%) presented the main seed fatty acids of &lt;em&gt;Opuntia dilleniid&lt;/em&gt;. Other essential oils were detected but at low percentage. Interestingly, stearic acid content in Cactus oil presented 7.51%, which is much higher than soybeans (~3%) that are considered as the largest source of animal protein feed and the second largest source of vegetable oil worldwide. Stearic acid presents neutral effects on the concentration of blood serum LDL cholesterol and does not exhibit cholesterolemic effects on human health. The analysis of cactus seed oil demonstrated a strong antioxidant ability estimated by their capability to reduce oxidation. Treated cake with BHT (butylated hydroxytoluene) at concentration of 0.02 mg/100g of butter from cactus seed-oil exhibited lower peroxide values ranging from 0.67 to 1.5 milli-equivalents (meq) peroxide per 1 kg of oil throughout 15 days of storage time at 4 °C. In contrast, treated cake with 0.11 mg/100g of butter from cactus seed-oil presented lower peroxide values ranged from 0.69 to 2.5 meq peroxide per 1 kg of oil among all treatments. Because of its high-saturated fatty acid composition (&amp;gt;22%) and rich linoleic acid (72.9%) composition, &lt;em&gt;Opuntia dillenii&lt;/em&gt; present an alternative source with several health benefits by lowering cholesterol risks and for biodiesel production.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">579</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Alya Jameel Ali Alsaad&lt;sup&gt;1&lt;/sup&gt;, Ammar B Altemimi&lt;sup&gt;1&lt;/sup&gt;*, Salah Naji Aziz&lt;sup&gt;1&lt;/sup&gt;, Naoufal Lakhssassi&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Food Science-College of Agriculture-University of Basrah, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Plant, Soil and Agricultural Systems, Southern Illinois University, Carbondale, IL 62901, USA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kausik Bhar</style></author><author><style face="normal" font="default" size="100%">Sumanta Mondal</style></author><author><style face="normal" font="default" size="100%">Padilam Suresh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An Eye-Catching Review of Aegle marmelos L. (Golden Apple)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aegle marmelos</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacological activities</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional use</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">207-224</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Plants and their products are a major source for food and medicine that are highly beneficial for various animals and humans. This article focuses on complete profile of &lt;em&gt;Aegle marmelos&lt;/em&gt; L. which belongs to the family &lt;em&gt;Rutaceae&lt;/em&gt;, is commonly known as bael, widely available in several places in India. &lt;strong&gt;Ethnobotany:&lt;/strong&gt; Traditional use of &lt;em&gt;A. marmelos&lt;/em&gt; for various diseases includes abdominal disorders, ulcer, cholera, diarrhea, nerve disorders, gonorrhea, heart disorders, dog bite, jaundice, snake bite and many more. A number of biologically active compounds isolated from various parts of &lt;em&gt;A. marmelos&lt;/em&gt; which belongs to various chemical groups. &lt;strong&gt;Phytochemistry:&lt;/strong&gt; The isolated components belong to Alkaloids, Terpenoids, Vitamins, Coumarins, Tannins, Carbohydrates, Flavonoids, Fatty Acids, Essential Oils and some other miscellaneous compounds. Pharmacological Activities: The plant also possess various pharmacological activities such as Antioxidant, Antibacterial, Antifungal, Antidiarrheal, Antidiabetic, Antiproliferative, Cytoprotective, Hepatoprotective, Antifertility, Analgesic, Antiarthritis, Contractile, Antihyperlipidemic, Cardioprotective, Radioprotective, Anticancer, Antiviral, Antiulcer, Immunomodulatory and Wound Healing properties. &lt;strong&gt;Conclusion:&lt;/strong&gt; Hence this review can be a good reference for researchers who are willing to undertake further investigation about &lt;em&gt;A. marmelos.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">207</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Kausik Bhar&lt;sup&gt;1,&lt;/sup&gt;*, Sumanta Mondal&lt;sup&gt;2&lt;/sup&gt;, Padilam Suresh&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, School of Pharmacy, Guru Nanak Institutions Technical Campus, Ibrahimpatnam, Telangana, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutics, School of Pharmacy, Guru Nanak Institutions Technical Campus, Ibrahimpatnam, Telangana, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chanate Wanna</style></author><author><style face="normal" font="default" size="100%">Montarop Sudhadham</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Coconut Water and Boiling on Antioxidant Activity and Total Phenolic Contents in Schizophyllum commune Fr.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Coconut water</style></keyword><keyword><style  face="normal" font="default" size="100%">Free Radicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Schizophyllum commune Fr</style></keyword><keyword><style  face="normal" font="default" size="100%">Total Phenolic Contents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">925-931</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Schizophyllum commune&lt;/em&gt; Fr., a split gill mushroom has been acknowledged for its medicinal properties.&amp;nbsp;&lt;strong&gt; Aims:&lt;/strong&gt; The present study was to evaluate the effect of coconut water and boiling on antioxidant activity and total phenolic contents in &lt;em&gt;Schizophyllum commune&lt;/em&gt; Fr. &lt;strong&gt;Settings and Design:&lt;/strong&gt; The experiment was completely randomized design (CRD) using tender and mature coconut water compared to synthetic hormone at concentration of 50% and 100% in volume of 5 and 10 ml. The first group is fresh mushrooms and the second group is boiled mushroom then was dried in hot air oven at 45&amp;deg;C for 48 hr. Materials and Methods: The &lt;em&gt;S. commune&lt;/em&gt; was extracted with ethanol and then was evaluated the scavenging activity by DPPH and FRAP assay and Folin-Ciocalteau method was used to determine total phenolic contents. &lt;strong&gt;Statistical analysis used:&lt;/strong&gt; The data were recorded as means &amp;plusmn; standard deviations and analyzed by using SPSS version 21. The mean values of data were subjected to a oneway analysis of variance (ANOVA) and the significance of the difference between means was determined by the Tukey&amp;rsquo;s multiple comparison tests at 95% least significance difference (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.05). Pearson correlation coefficient was used to determine the relationship between the antioxidant activity and total phenolic contents in sample extracts. &lt;strong&gt;Results:&lt;/strong&gt; In fresh mushroom group showed higher antioxidant activity and total phenolic contents than boiled mushroom group. When compared to a loss of antioxidant activity and total phenolic contents after boiling only the experiments with coconut water found that tender coconut water 50% of 5 ml has the lowest of loss in TEAC and total phenolic contents as 9.28% and 9.85% respectively. Mature coconut water 100% of 10 ml has the lowest of loss in FRAP as 2.77% and followed by tender coconut water 50% of 5 ml as 4.82% which were lower than control treatment but similar with synthetic hormone of 5 ml. The relationship between antioxidant activity and total phenolic contents of mushrooms was low in both groups. &lt;strong&gt;Conclusions:&lt;/strong&gt; It concluded that tender coconut water 50% of 5 ml could maintain the antioxidant properties and total phenolic compounds in S. commune.&amp;nbsp;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">925</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Chanate Wanna&lt;sup&gt;1*&lt;/sup&gt; and Montarop Sudhadham&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Biology, Faculty of Science and Technology, Suan Sunandha Rajabhat University, Bangkok 10300, THAILAND.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Biology, Faculty of Science and Technology, Suan Sunandha Rajabhat University, Bangkok 10300, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chanate Wanna</style></author><author><style face="normal" font="default" size="100%">Montarop Sudhadham</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Coconut Water and Boiling on Antioxidant Activity and Total Phenolic Contents in Schizophyllum commune Fr.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July/2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">73-77</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Schizophyllum commune&lt;/em&gt; Fr., a split gill mushroom has been acknowledged for its medicinal properties. &lt;strong&gt;Aims:&lt;/strong&gt; The present study was to evaluate the effect of coconut water and boiling on antioxidant activity and total phenolic contents in &lt;em&gt;Schizophyllum commune&lt;/em&gt; Fr. &lt;strong&gt;Settings and Design&lt;/strong&gt;: The experiment was completely randomized design (CRD) using tender and mature coconut water compared to synthetic hormone at concentration of 50% and 100% in volume of 5 and 10 ml. The first group is fresh mushrooms and the second group is boiled mushroom then was dried in hot air oven at 45&amp;deg;C for 48 hr. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The &lt;em&gt;S. commune&lt;/em&gt; was extracted with ethanol and then was evaluated the scavenging activity by DPPH and FRAP assay and Folin-Ciocalteau method was used to determine total phenolic contents. &lt;strong&gt;Statistical analysis&lt;/strong&gt; &lt;strong&gt;used:&lt;/strong&gt; The data were recorded as means &amp;plusmn; standard deviations and analyzed by using SPSS version 21. The mean values of data were subjected to a oneway analysis of variance (ANOVA) and the significance of the difference between means was determined by the Tukey&amp;rsquo;s multiple comparison tests at 95% least significance difference (p &amp;lt; 0.05). Pearson correlation coefficient was used to determine the relationship between the antioxidant activity and total phenolic contents in sample extracts. &lt;strong&gt;Results:&lt;/strong&gt; In fresh mushroom group showed higher antioxidant activity and total phenolic contents than boiled mushroom group. When compared to a loss of antioxidant activity and total phenolic contents after boiling only the experiments with coconut water found that tender coconut water 50% of 5 ml has the lowest of loss in TEAC and total phenolic contents as 9.28% and 9.85% respectively. Mature coconut water 100% of 10 ml has the lowest of loss in FRAP as 2.77% and followed by tender coconut water 50% of 5 ml as 4.82% which were lower than control treatment but similar with synthetic hormone of 5 ml. The relationship between antioxidant activity and total phenolic contents of mushrooms was low in both groups. &lt;strong&gt;Conclusions&lt;/strong&gt;: It concluded that tender coconut water 50% of 5 ml could maintain the antioxidant properties and total phenolic compounds in &lt;em&gt;S. commune&lt;/em&gt;.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt; Key-words:&lt;/strong&gt; Antioxidant, Free radicals, Total phenolic contents, Coconut water, &lt;em&gt;Schizophyllum commune&lt;/em&gt; Fr.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key Messages:&lt;/strong&gt; The tender coconut water 50% of 5 ml was suitable for holding the antioxidant properties and total phenolic contents and also boiling affect to loss of antioxidant compounds in &lt;em&gt;S. commune&lt;/em&gt;. The findings from this study provide information for alternative selection of coconut water as natural hormone.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Chanate Wanna&lt;sup&gt;1&lt;/sup&gt;* and Montarop Sudhadham&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;1Division of Biology, Faculty of Science and Technology, Suan Sunandha Rajabhat University, Bangkok 10300, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;2Division of Biology, Faculty of Science and Technology, Suan Sunandha Rajabhat University, Bangkok 10300, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sindhura Srinivasula</style></author><author><style face="normal" font="default" size="100%">Chinna Eswaraiah Maram</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Dalechampia indica Wight Extract Fractions on Behavioral and Biochemical Abnormalities following Ischemia-Reperfusion Insult in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BCCAO</style></keyword><keyword><style  face="normal" font="default" size="100%">Dalechampia indica</style></keyword><keyword><style  face="normal" font="default" size="100%">Ferric chloride</style></keyword><keyword><style  face="normal" font="default" size="100%">Reperfusion</style></keyword><keyword><style  face="normal" font="default" size="100%">Thrombosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/363</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">39-44</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the cerebro protective effect of &lt;em&gt;Dalechampia indica &lt;/em&gt;(DI) ethanolic (EDI) and chloroform (CDI) extract fractions against cerebral ischemia- reperfusion insult in rats. &lt;strong&gt;Method:&lt;/strong&gt; The rats were treated with different doses (200 and 400 mg/kg) of EDI and CDI orally once daily for 30 days. After completion of pre-treatment, ischemia was induced by blocking bilateral common carotid arteries (BCCAO) for 30 mins followed by reperfusion and ferric chloride induced thrombosis. The post treatment was continued for another week after surgery. The behavioral parameters were assessed and finally, rats were sacrificed to isolate the brains to estimate biochemical parameters.&amp;nbsp;&lt;strong&gt;Results:&lt;/strong&gt; Combination of global (BCCAO) and focal (Thrombosis) ischemic model along with reperfusion has induced prominent ischemic insult indicated by antioxidant enzymes depletion and elevation of lipid peroxidation. Pre-treatment with different doses of EDI and CDI significantly improved the levels of superoxide dismutase (SOD), glutathione enzymes (GPx, GSH, GST, GR), catalase (CAT) and decreased the lipid peroxidation. &lt;strong&gt;Conclusion:&lt;/strong&gt; Results established Cerebro protective role of Ethanolic extract fraction of DI in cerebrovascular insufficiency states and cerebral ischemic-reperfusion injury produced by bilateral common carotid artery ligation along with reperfusion and thrombosis which may attribute to presence of alkaloids,flavonoids, and phenolic compounds.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">39</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sindhura Srinivasula&lt;sup&gt;1&lt;/sup&gt;*, Chinna Eswaraiah Maram&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Department of Pharmaceutical Science, JNTUH, Hyderabad, Telangana, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Anurag Pharmacy College, Kodad, Telangana, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohd Adzim Khalili Rohin</style></author><author><style face="normal" font="default" size="100%">Mimie Noratiqah Jumli</style></author><author><style face="normal" font="default" size="100%">Norhaslinda Ridzwan</style></author><author><style face="normal" font="default" size="100%">Atif Amin Baig</style></author><author><style face="normal" font="default" size="100%">Ahmad Zubaidi Abdul Latif</style></author><author><style face="normal" font="default" size="100%">Norhayati Abd Hadi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Gynura procumbens Extracts on Anti-Proliferative Activity and its Associated Morphological Changes of Human Glioblastoma multiforme Cell Line (U-87)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiproliferative.</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Gynura procumbens</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanol</style></keyword><keyword><style  face="normal" font="default" size="100%">U87 cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">x</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">XX-XX</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Gynura procumbens&lt;/em&gt; (Lour.) Merr is a well-known traditional herb and is widely used for traditional medicine by human. Previous clinical studies have shown the benefit effect of this leaves with inflammation, high blood pressure and others. This study aims to investigate the effect of methanol, ethanol, and ethyl acetate extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; on U-87 cell line, human &lt;em&gt;glioblastoma multiforme&lt;/em&gt; cell line. &lt;strong&gt;Methods:&lt;/strong&gt; In the present study, effect of methanol, ethanol and ethyl acetate extracts on U-87 cell line was determined by MTT-based anti-proliferative assay and any significant changes to the cells towards apoptotic changes was observed under a light microscope. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; was found to have high anti-proliferative effect on U-87 cell line with IC&lt;sub&gt;50&lt;/sub&gt; less than 20&amp;mu;g/ml. By comparing IC&lt;sub&gt;50&lt;/sub&gt; value, ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; had high potential for anti-proliferative effect on U- 87 cell line. Therefore, ethanol and methanol extracts can be a potential anti-proliferative effect on U-87 cell line. &lt;strong&gt;Conclusion:&lt;/strong&gt; To the best of our knowledge, this is the first study of exploring the effect of &lt;em&gt;Gynura procumbens&lt;/em&gt; extracts using three different polarity (methanol, ethanol, ethyl acetate) effect on U-87 cell line, Human &lt;em&gt;glioblastoma multiforme&lt;/em&gt; cells.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; &lt;em&gt;Gynura procumbens&lt;/em&gt;, Ethanol, Methanol, U87 cell line, Antiproliferative.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2s</style></issue><work-type><style face="normal" font="default" size="100%">x</style></work-type><section><style face="normal" font="default" size="100%">XX</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohd Adzim Khalili Rohin&lt;sup&gt;1,3,4&lt;/sup&gt;, Mimie Noratiqah Jumli&lt;sup&gt;1&lt;/sup&gt;, Norhaslinda Ridzwan&lt;sup&gt;1&lt;/sup&gt;, Atif Amin Baig&lt;sup&gt;2&lt;/sup&gt;, Ahmad Zubaidi Abdul Latif&lt;sup&gt;2&lt;/sup&gt;, Norhayati Abd Hadi&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Nutrition and Dietetic, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Medical Campus, 20400 Kuala Terengganu, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centre for Continuing Education (CCE), Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute for Community (Health) Development, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohd Adzim Khalili Rohin</style></author><author><style face="normal" font="default" size="100%">Mimie Noratiqah Jumli</style></author><author><style face="normal" font="default" size="100%">Norhaslinda Ridzwan</style></author><author><style face="normal" font="default" size="100%">Atif Amin Baig</style></author><author><style face="normal" font="default" size="100%">Ahmad Zubaidi Abdul Latif</style></author><author><style face="normal" font="default" size="100%">Norhayati Abd Hadi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Gynura procumbens Extracts on Anti-Proliferative Activity and its Associated Morphological Changes of Human Glioblastoma multiforme Cell Line (U-87)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiproliferative</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Gynura procumbens</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanol</style></keyword><keyword><style  face="normal" font="default" size="100%">U87 cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/514</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">492-496</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Gynura procumbens&lt;/em&gt; (Lour.) Merr is a well-known traditional herb and is widely used for traditional medicine by human. Previous clinical studies have shown the benefit effect of this leaves with inflammation, high blood pressure and others. This study aims to investigate the effect of methanol, ethanol, and ethyl acetate extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; on U-87 cell line, human &lt;em&gt;Glioblastoma multiforme&lt;/em&gt; cell line. &lt;strong&gt;Methods:&lt;/strong&gt; In the present study, effect of methanol, ethanol and ethyl acetate extracts on U-87 cell line was determined by MTT-based anti-proliferative assay and any significant changes to the cells towards apoptotic changes was observed under a light microscope. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; was found to have high anti-proliferative effect on U-87 cell line with IC&lt;sub&gt;50&lt;/sub&gt; less than 20&amp;mu;g/ml. By comparing IC&lt;sub&gt;50&lt;/sub&gt; value, ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; had high potential for anti-proliferative effect on U- 87 cell line. Therefore, ethanol and methanol extracts can be a potential anti-proliferative effect on U-87 cell line. &lt;strong&gt;Conclusion:&lt;/strong&gt; To the best of our knowledge, this is the first study of exploring the effect of &lt;em&gt;Gynura procumbens&lt;/em&gt; extracts using three different polarity (methanol, ethanol, ethyl acetate) effect on U-87 cell line, Human &lt;em&gt;Glioblastoma multiforme&lt;/em&gt; cells.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">492</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohd Adzim Khalili Rohin&lt;sup&gt;1,3,4&lt;/sup&gt;, Mimie Noratiqah Jumli&lt;sup&gt;1&lt;/sup&gt;, Norhaslinda Ridzwan&lt;sup&gt;1&lt;/sup&gt;, Atif Amin Baig&lt;sup&gt;2&lt;/sup&gt;, Ahmad Zubaidi Abdul Latif&lt;sup&gt;2&lt;/sup&gt;, Norhayati Abd Hadi&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Nutrition and Dietetic, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Medical Campus, 20400 Kuala Terengganu, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centre for Continuing Education (CCE), Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute for Community (Health) Development, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Murthy Meenapriya</style></author><author><style face="normal" font="default" size="100%">Roy Anitha</style></author><author><style face="normal" font="default" size="100%">Thangavelu Lakshmi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Lutein on Cytochrome P450 (Isoform CYP3A4) - An in vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CYP3A4</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytochrome P450</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibitory assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Lutein</style></keyword><keyword><style  face="normal" font="default" size="100%">Marigold</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1093-1095</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Lutein is a carotenoids vitamin rich in many fruits and vegetables and also available in multivitamin products. It is consumed for its effect on eye disease, cancer, diabetes and other health conditions. Recently, herbal preparations are increasingly used in healthcare systems and concomitant administration of synthetic medications may cause pharmacokinetic or pharmacodynamic interactions leading to very serious medical problems. Understanding the ability of herbal extracts and preparations to modulate the metabolizing enzymes can help the health system for proper treatment of patients and thereby can avoid many adverse effects associated with it. The aim of the study was to find the effect of lutein isolated from &lt;em&gt;Tagetes erecta&lt;/em&gt; L on cytochrome P450 isoform CYP3A4. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The different concentrations of lutein (5 &amp;ndash; 100&amp;mu;g/ml), potassium phosphate buffer, CYP450 reagent and substrate 7-Benzyloxy-4-trifluoromethylcoumarin (BFC) were added to a 96-well plate. The fluorescent intensities of the products were measured by Perkin Elmer Enspire fluorescence reader using an excitation and emission wavelength of 405 nm and 460 nm, respectively to examine the effect of lutein on Cytochrome P 450 isoform CYP3A4 and the IC&lt;sub&gt;50&lt;/sub&gt; was calculated by plotting concentrations of lutein against the corresponding percent inhibition. &lt;strong&gt;Results:&lt;/strong&gt; All the tested concentrations of lutein showed potent inhibition against CYP3A4 in a dose &amp;ndash; dependent manner. The IC&lt;sub&gt;50&lt;/sub&gt; value was found to be 35.27&amp;mu;g/ml. &lt;strong&gt;Conclusion:&lt;/strong&gt; The inhibitory effect of lutein indicates the possibilities of herb-drug interaction if it is co &amp;ndash; administered with prescribed drugs that are normally metabolised by CYP3A4 enzyme.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1093</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Murthy&amp;nbsp; Meenapriya&lt;sup&gt;1&lt;/sup&gt;, Roy&amp;nbsp;&amp;nbsp;Anitha&lt;sup&gt;2&lt;/sup&gt;, Thangavelu&amp;nbsp;&amp;nbsp; Lakshmi &lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Student, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Velappanchavadi, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Velappanchavadi, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ampa Konsue</style></author><author><style face="normal" font="default" size="100%">Chusri Talubmook</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A. indicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Fasting blood glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">M. pudica</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai folklore recipe</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/512</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">480-485</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Abutilon indicum&lt;/em&gt; and &lt;em&gt;Mimosa pudica&lt;/em&gt; were a folklore recipe in Northeastern of Thailand. The recipe was reported that claim to diabetic treatment. &lt;strong&gt;Aims:&lt;/strong&gt; The studies were evaluated to hypoglycemic effect, serum insulin secretion and blood biochemistry in streptozotocin (STZ)-induced diabetic rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The recipe were composed of whole plants from &lt;em&gt;A. indicum&lt;/em&gt; and &lt;em&gt;M. Pudica&lt;/em&gt; (1:1 w/w) powder. The pound plants were macerated with aqueous (AMA), hydro-ethanol (AMHE) and 80% ethanol (AME) to crude extracts. The AMA, AMHE and AME at the doses of 125, 250 and 500 mg/kg body weight (b.w.) were administered orally daily in diabetic rats during eight weeks. Fasting blood glucose levels (FBG) were measured at weekly. The serum insulin levels and blood biochemical data including blood urea nitrogen (BUN), creatinine (CREA), total protein (TP), albumin (Alb), serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were estimated at the end of experiment. &lt;strong&gt;Results:&lt;/strong&gt; All doses of the extracts were showed significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05) decreasing percent age of FBG in diabetic rats. Especially, AME 125 mg/ kg b.w. was showed more potent significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05) decreasing percentage of FBG at week of 2, 5, 7 and 8. The serum insulin levels of all doses administered with the extracts were significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt; 0.05) higher than diabetic control group. On the other hand, all doses of the extracts were significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt; 0.05) decreasing ALT and ALP lower than diabetic control group. While, AMA and AMHE at the doses of 250 and 500 mg/kg b.w. were increased HDL, but decreased TC, TG and LDL. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study was proved to diabetic treatment and improvement of diabetic stage and blood biochemical parameters. In addition, the experiment was confirmed to folklore traditional use.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">480</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ampa Konsue&lt;sup&gt;1*&lt;/sup&gt;, Chusri Talubmook&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Sciences, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ampa Konsue</style></author><author><style face="normal" font="default" size="100%">Chusri Talubmook</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A. indicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Fasting blood glucose.</style></keyword><keyword><style  face="normal" font="default" size="100%">M. pudica</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai folklore recipe</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">x</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">x</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Abutilon indicum&lt;/em&gt; and &lt;em&gt;Mimosa pudica&lt;/em&gt; were a folklore recipe in Northeastern of Thailand. The recipe was reported that claim to diabetic treatment. &lt;strong&gt;Aims:&lt;/strong&gt; The studies were evaluated to hypoglycemic effect, serum insulin secretion and blood biochemistry in streptozotocin (STZ)-induced diabetic rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The recipe were composed of whole plants from &lt;em&gt;A. indicum&lt;/em&gt; and &lt;em&gt;M. Pudica&lt;/em&gt; (1:1 w/w) powder. The pound plants were macerated with aqueous (AMA), hydro-ethanol (AMHE) and 80% ethanol (AME) to crude extracts. The AMA, AMHE and AME at the doses of 125, 250 and 500 mg/kg body weight (b.w.) were administered orally daily in diabetic rats during eight weeks. Fasting blood glucose levels (FBG) were measured at weekly. The serum insulin levels and blood biochemical data including blood urea nitrogen (BUN), creatinine (CREA), total protein (TP), albumin (Alb), serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were estimated at the end of experiment. &lt;strong&gt;Results:&lt;/strong&gt; All doses of the extracts were showed significantly (p&amp;lt;0.05) decreasing percent age of FBG in diabetic rats. Especially, AME 125 mg/ kg b.w. was showed more potent significantly (p&amp;lt;0.05) decreasing percentage of FBG at week of 2, 5, 7 and 8. The serum insulin levels of all doses administered with the extracts were significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt; 0.05) higher than diabetic control group. On the other hand, all doses of the extracts were significantly (p&amp;lt; 0.05) decreasing ALT and ALP lower than diabetic control group. While, AMA and AMHE at the doses of 250 and 500 mg/kg b.w. were increased HDL, but decreased TC, TG and LDL. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study was proved to diabetic treatment and improvement of diabetic stage and blood biochemical parameters. In addition, the experiment was confirmed to folklore traditional use.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Thai folklore recipe, A. indicum , M. pudica , Fasting blood glucose.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2s</style></issue><work-type><style face="normal" font="default" size="100%">x</style></work-type><section><style face="normal" font="default" size="100%">x</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ampa Konsue&lt;sup&gt;1*&lt;/sup&gt;, Chusri Talubmook&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Sciences, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">shreelakshmidevi singaravelu</style></author><author><style face="normal" font="default" size="100%">Jaikumar Sankarapillai</style></author><author><style face="normal" font="default" size="100%">Abilash Sasidaran Chandrakumari</style></author><author><style face="normal" font="default" size="100%">Pammy Sinha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Trigonella foenum gracecum (fenugreek) Seed Extract in Experimentally Induced Gastric Ulcer in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fenugreek</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastro-protection</style></keyword><keyword><style  face="normal" font="default" size="100%">Indomethacin</style></keyword><keyword><style  face="normal" font="default" size="100%">seed-extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Ulcer inhibition</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1169-1173</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Trigonella foenum graceum&lt;/em&gt; (Fenugreek) seeds are commonly used in India as traditional medicine for Diabetes, Dysmenorrhea, lactation and arthritis. The gastro-protective role of Fenugreek seeds are yet to be explored. &lt;strong&gt;Objectives:&lt;/strong&gt; To evaluate the effect of Fenugreek seed extract in Indomethacin induced gastric ulcer models. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Albino wistar rats were divided into five groups with eight animals in each. Gastric ulcer was induced using Indomethacin 20 mg/Kg. Fenugreek at dose of 200mg/Kg and 400mg/Kg was administered to group III, IV and group V received Rantidine 30mg/Kg. Ulcer index, volume of gastric juice and acidity was estimated. To study the anti-oxidant property the level of catalase, SOD, GST and T. Bars were done. &lt;strong&gt;Results:&lt;/strong&gt; Fenugreek treated group III showed a significant decrease in ulcer index, volume of gastric juice and acidity when compared to control positive group II. Oxidative enzyme study indicated a significant increase in Catalase, SOD and GSH value in treated group when compared with control positive group II and significant decrease in T. Bars value in treated group. &lt;strong&gt;Conclusion:&lt;/strong&gt; Fenugreek seed extract has both gastro-protective and Anti-oxidant property.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1169</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shreelakshmidevi Singaravelu&lt;sup&gt;1,5&lt;/sup&gt;*, Jaikumar Sankarapillai&lt;sup&gt;2&lt;/sup&gt;, Abilash Sasidaran Chandrakumari&lt;sup&gt;3,5&lt;/sup&gt;, Pammy Sinha&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Science Medical College and Hospital, Puducherry, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pathology, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth (DU), Chennai, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pathology, Sri Lakshmi Narayana Institute of Medical Science Medical College and Hospital, BIHER, Puducherry, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Research scholar, Bharath institute of higher education and research, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ladachart Taepongsorat</style></author><author><style face="normal" font="default" size="100%">Methin Phadungkit</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Asparagus racemosus Root Extracts on Serum Lipid Profiles, Lipid Peroxidation and Superoxide Dismutase in Ovariectomized Rat</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asparagus racemosus</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid profiles</style></keyword><keyword><style  face="normal" font="default" size="100%">Malondialdehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Ovariectomized rat</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxide dismutase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1036-1041</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Once rats have been ovariectomized they have a high risk of cardiovascular disease due to changes in the blood cholesterol and lipid profile. &lt;strong&gt;Objective:&lt;/strong&gt; To investigate the effects of &lt;em&gt;Asparagus racemosus&lt;/em&gt; (AR) root extract on the serum lipid profiles, lipid peroxidation and antioxidant levels in ovariectomized rats. &lt;strong&gt;Methods:&lt;/strong&gt; Twenty-five, two month-old female Wistar rats were randomly divided into five groups: SH, OVX,OEE, OAAR and OEAR. The daily doses of 500 mg/KgBW of the AR root extracts for five weeks.The levels of serum TG, TC, HDL, LDL, the liver, kidney and uterine tissue lipid peroxidation and SOD levels were determined. &lt;strong&gt;Results:&lt;/strong&gt; Serum TC and LDL showed no significant differences in any groups. Serum TG of the OAAR and OEAR groups were not significantly different. The serum HDL of the OAAR and OEAR groups were significantly lower than the OEE group. The liver MDA levels of the OAAR and OEAR groups were significantly decreased compared with the OVX and OEE groups while the SOD level of the OAAR group was significantly increased. The MDA levels in the kidney and uterine of the treated group showed no significant difference. The SOD levels in the kidney of the treated group were not different but the SOD levels in uterine were significantly decreased. &lt;strong&gt;Conclusion:&lt;/strong&gt; It can be believed that the lipid profiles were maybe regulated via estrogen.The AR extract has low effects on the lipid profiles at this dose and duration of treatment. The capacity of the extracts to decrease the MDA level and increase the SOD level in this study clearly reflected the antioxidant efficiency of these substances.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1036</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ladachart Taepongsorat&lt;sup&gt;1*&lt;/sup&gt;, Methin Phadungkit&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 1&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmaceutical Chemistry and Natural Products Research Unit, Faculty of Pharmacy, Mahasarakham University, Mahasarakham 44150, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author><author><style face="normal" font="default" size="100%">Riza Annisa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Dayak Onion Bulbs (Eleutherine bulbosa (Mill.) Urb) on Bone Development of the Hipoestrogen Model Rat.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacog Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bone calcium level</style></keyword><keyword><style  face="normal" font="default" size="100%">Bone length</style></keyword><keyword><style  face="normal" font="default" size="100%">Bone weight</style></keyword><keyword><style  face="normal" font="default" size="100%">Dayak onion bulbs</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoestrogen</style></keyword><keyword><style  face="normal" font="default" size="100%">Menopause</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January-2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/482</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">299-303</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Eleutherinol is a naphtoquinone derivative that has strong affinity to bind with estrogen alpha receptors (ER&amp;alpha;). This compound can be found in Dayak Onion Bulbs (&lt;em&gt;Eleutherine bulbosa&lt;/em&gt; Mill.). &lt;strong&gt;Objective:&lt;/strong&gt; The purpose of this study is to analyze the effects of Dayak Onion Bulbs extract on the growth of the bone of hypoestrogen model rat. &lt;strong&gt;Methods:&lt;/strong&gt; A total of 36 female white rats of &lt;em&gt;Sprague-Dawley&lt;/em&gt; were divided into 6 groups. All 6 groups receive CMC Na 0,5% (&lt;em&gt;sham group&lt;/em&gt;), CMC Na 0,5% (negative group), tamoxifen (positive group), three level of dayak onion bulbs extract doses namely dose 8 mg/ 200 g, 12 mg/ 200 g , and 18 mg/ 200 g. All groups, except the sham, is ovariectomized to obtain the conditions of hypoestrogen. After ovariectomy, all rats were evaluated for the success of ovariectomy on day 35, followed by the administration of the extracts by oral administration for 21 days. After 21 days administration, the level of bone calcium, bone weight, and bone length were measured by Atomic Absorption Spectrophotometry. &lt;strong&gt;Results:&lt;/strong&gt; Dayak onion bulbs extract at dose 3 (18 mg/200 g BW) could increase significantly bone calcium level, bone weight, and bone legnth of hypoestrogen rat. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results showed that Dayak onion bulbs extract could be developed to be a drug for menopause woman in the future.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">299</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Anton Bahtiar&lt;sup&gt;*&lt;/sup&gt;, Riza Annisa &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok,16424 West Java, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author><author><style face="normal" font="default" size="100%">Desta Andriyani</style></author><author><style face="normal" font="default" size="100%">Christoper Gunawan</style></author><author><style face="normal" font="default" size="100%">Nisrina Dhiah Fauziah</style></author><author><style face="normal" font="default" size="100%">Sutriyo Sutriyo</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Food Processing on Resveratrol and Total Phenolic Content in Melinjo (Gnetum gnemon L.) Seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Food processing</style></keyword><keyword><style  face="normal" font="default" size="100%">Gnetum gnemon L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Melinjo seeds</style></keyword><keyword><style  face="normal" font="default" size="100%">Resveratrol levels</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1096-1100</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Trans&lt;/em&gt;-resveratrol is a phenolic compound in the stilbene group present in Melinjo (&lt;em&gt;Gnetum gnemon&lt;/em&gt; L.) seeds. In Indonesia, these seeds are consumed by roasting, frying (i.e., emping), and boiling. This study aimed to evaluate the effects of food processing on trans-resveratrol and total phenolic compound levels in melinjo seeds. &lt;strong&gt;Methods:&lt;/strong&gt; Melinjo seed was roasted at 145&lt;sup&gt;o&lt;/sup&gt;C for 10 and 20 min, boiled at 100&lt;sup&gt;o&lt;/sup&gt;C for 5, 15, and 30 min, and fried at 160-170&lt;sup&gt;o&lt;/sup&gt;C for 2 and 4 min. Samples were refluxed with 96% ethanol. The determination of&lt;em&gt; trans&lt;/em&gt;-resveratrol levels was performed using high-performance liquid chromatography (HPLC), and total phenolic content was determined using Folin-Ciocalteu method. &lt;strong&gt;Results:&lt;/strong&gt; Based on the results, it was found that &lt;em&gt;trans&lt;/em&gt;-resveratrol and total phenolic content levels in Melinjo powder decreased from 36% to 10% (&lt;em&gt;trans&lt;/em&gt;-resveratrol) and 15% to 4% (total phenolic) after 20 min of roasting, and in fried empings, it decreased 60%, 68%, and 92% (&lt;em&gt;trans&lt;/em&gt;-resveratrol) and 41%, 45%, 97% (total phenolic) after 5, 15, and 30 min of boiling, respectively.&lt;strong&gt; Conclusion:&lt;/strong&gt; There were significant changes in trans-resveratrol levels and total phenolic content in Melinjo seeds before and after various cooking processes (i.e., roasting, boiling, and frying).&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1096</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Islamudin Ahmad&lt;sup&gt;1&lt;/sup&gt;, Desta Andriyani&lt;sup&gt;2&lt;/sup&gt;, Christoper Gunawan&lt;sup&gt;2&lt;/sup&gt;, Nisrina Dhiah Fauziah&lt;sup&gt;2&lt;/sup&gt;, Sutriyo Sutriyo&lt;sup&gt;3&lt;/sup&gt;, Abdul Mun&amp;rsquo;im&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmaceutical Research and Development of FARMAKA TROPIS, Faculty of Pharmacy, Mulawarman University, Samarinda, East Kalimantan, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmaceutics, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sirirat Deeseenthum</style></author><author><style face="normal" font="default" size="100%">Vijitra Luang-In</style></author><author><style face="normal" font="default" size="100%">Stephen Moses John</style></author><author><style face="normal" font="default" size="100%">Pheeraya Chottanom</style></author><author><style face="normal" font="default" size="100%">Supaporn Chunchom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Kefir Fermentation on Antioxidation Activities (in vitro) and Antioxidative Stress (in vivo) of Three Thai Rice Milk Varieties Prepared by Ultrasonication Technique</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Lactic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Rice kefir</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai rice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1061-1066</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aims:&lt;/strong&gt; The effects of kefir fermentation were investigated on antioxidation activities (&lt;em&gt;in vitro&lt;/em&gt;) and antioxidative stress (&lt;em&gt;in vivo&lt;/em&gt;) for different Thai rice; Hawm Nil rice, Red Hawm rice and Khao Dawk Mali 105 rice. &lt;strong&gt;Methodology:&lt;/strong&gt; Antioxidant activity (&lt;em&gt;in vitro&lt;/em&gt;) was investigated using ferric reducing antioxidant power and 2, 2&amp;acute;-diphenyl-1-picrylhydrazyl assays. In addition, antioxidative stress (&lt;em&gt;in vivo&lt;/em&gt;) was performed using colitis rat models to study nitric oxide (NO), lipid peroxidation (LPO) and superoxide dismutase (SOD) compared with rats treated with prednisolone and cow&amp;rsquo;s milk kefir. &lt;strong&gt;Results:&lt;/strong&gt; Antioxidant activity of rice kefir powder from both assays had higher antioxidant activity than cow&amp;rsquo;s milk kefir powder. NO levels of colitis rats received Hawm Nil rice kefir powder (HNKP) was reduced when compared to phosphate buffered saline (PBS) group. Moreover, colitis rats received HNKP did not differ in NO levels from colitis rats that received prednisolone and non-colitis rats. The result of LPO product malondialdehyde (MDA) indicated that colitis rats treated with HNKP had reduced TBARS compared to PBS group, and did not differ in TBARS levels from rats that received prednisolone and non-colitis rats. Surprisingly, increase in SOD activity was observed in colitis rats that received HNKP compared to PBS, with similar results of increased SOD in rats that received prednisolone and cow&amp;rsquo;s milk kefir powder. &lt;strong&gt;Conclusion:&lt;/strong&gt; Hawm Nil rice kefir may offer a protective effect for antioxidative stress resulting from chemical induction; it has potential as a supplementary food with high antioxidant activity and is regarded as safe for consumer health.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1061</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sirirat Deeseenthum&lt;sup&gt;1,2*&lt;/sup&gt;, Vijitra Luang-In&lt;sup&gt;1,2&lt;/sup&gt;, Stephen Moses John&lt;sup&gt;1,2&lt;/sup&gt;, Pheeraya Chottanom&lt;sup&gt;1,3&lt;/sup&gt;, Supaporn Chunchom&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Natural Antioxidant Innovation Research Unit (NAIRU), Faculty of Technology, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Faculty of Technology, Mahasarakham University, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Food Technology and Nutrition, Faculty of Technology, Mahasarakham University, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Rajamangala University of Technology Isan, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ratikorn Chatchanayuenyong</style></author><author><style face="normal" font="default" size="100%">Patcharawan Sujayanont</style></author><author><style face="normal" font="default" size="100%">Auranut Vuttivirojana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Leucaena leucocephala (Lam.) de Wit Leaves Extracts in Culture of Human Umbilical Vein Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">De Wit</style></keyword><keyword><style  face="normal" font="default" size="100%">Leucaena leucocephala (Lam.)</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxide dismutase</style></keyword><keyword><style  face="normal" font="default" size="100%">Vascular endothelial.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/411</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">148-153</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Oxidative stress can induce vascular endothelial dysfunction in diabetic and hyperlipidemia patients. &lt;em&gt;Leucaena leucocephala&lt;/em&gt; (Lam.) de Wit has been reported of possessing antioxidant, antidiabetic and anticholiesterase activity; as well as the toxic substance called mimosine. &lt;strong&gt;Aims:&lt;/strong&gt; To determine antioxidant effects of&lt;em&gt; Leucaena leucocephala&lt;/em&gt; (Lam.) de Wit Leave extracts in oxidative stress induced vascular endothelial function. &lt;strong&gt;Methods and Material:&lt;/strong&gt; Leave extracts were determined for antioxidant activity. Either or both of oxidized low density lipoprotein (oxLDL) and glucose were applied to induce oxidative stress condition in human umbilical vein cultured (HUVCs) to observe superoxide dismutase (SOD) activity, nitric oxide (NO) level and morphological changes. &lt;strong&gt;Results:&lt;/strong&gt; Total polyphenol and flavonoid were 51.04 &amp;plusmn; 0.91 mg GAE/g and 0.13 &amp;plusmn; 0.01 mg catechin/g of dried weight (DW), respectively. Free radical reduction efficiency of crude extract observed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay showed IC&lt;sub&gt;50&lt;/sub&gt; value of 329.6 &amp;mu;g of vitamin C equivalent/mg of extracts. Frap value was showed 428.54 &amp;plusmn; 15.32 mM FeII equivalent/g of DW. The result observing in HUVCs showed that comparing to the control, SOD activity, NO and MDA level were maintained in 0.05 mg/mL of &lt;em&gt;L. leucocephala &lt;/em&gt;treated group, but NO and MDA level were lowered when comparing with oxLDL and glucose-induced oxidative stress. No change was observed in 0.05 mg/mL of &lt;em&gt;L. leucocephala&lt;/em&gt; treated group, comparing with control group. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study has been performed to exhibit the antioxidant activity of &lt;em&gt;L. leucocephala&lt;/em&gt; in endothelium functions and has been found to have an appropriate concentration at 0.05 mg/mL in reducing oxidative stress condition in impaired fasting blood glucose patients. Nevertheless, the optimal level for toxic activity in inhibition of cancer angiogenesis should be further investigated.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">148</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ratikorn Chatchanayuenyong&lt;sup&gt;1,2&lt;/sup&gt;*, Patcharawan Sujayanont&lt;sup&gt;1,2&lt;/sup&gt;, Auranut Vuttivirojana&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Biomedical Department, Faculty of Medicine, Mahasarakham University, Mahasarakham, THAILAND.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Epidemiology Unit, Faculty of Medicine, Mahasarakham University, Mahasarakham, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marni Karo</style></author><author><style face="normal" font="default" size="100%">Mochammad Hatta</style></author><author><style face="normal" font="default" size="100%">WaOde Salma</style></author><author><style face="normal" font="default" size="100%">Ilhamjaya Patellongi</style></author><author><style face="normal" font="default" size="100%">Rosdiana Natzir</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Miana (Coleus scutellariodes (L) Benth) to Expression of mRNA IL-37 in Balb/c Mice Infected Candida albicans</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CFU</style></keyword><keyword><style  face="normal" font="default" size="100%">Interleukin-37 mRNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Miana</style></keyword><keyword><style  face="normal" font="default" size="100%">Realtime PCR</style></keyword><keyword><style  face="normal" font="default" size="100%">Vulvovaginal Candidiasis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/358</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">16-19</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Miana (&lt;em&gt;Coleus scutellariodes&lt;/em&gt; (L) Benth) are a herbal medicine with potential anti-inflammatory properties in patients infected with vulvovaginal candidiasis. The objective of this work was to the analyze IL-37 expression following administration of miana leaf extract (MLE) in an animal model of vulvovaginal candidiasis. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Adult Balb/c mice, aged 8&amp;ndash;12 weeks and weighing 30&amp;ndash;40 g, were divided into five groups. Four groups were administered &lt;em&gt;Candida albicans&lt;/em&gt; via intravaginal inoculation with a diluted dose of 10&lt;sup&gt;-2&lt;/sup&gt;/ ml and were treated with either MLE, a placebo, or ketoconazole; one group constituted the healthy control and was only treated with MLE. Real-time PCR was used to measure the expression of IL-37. &lt;strong&gt;Results:&lt;/strong&gt; These findings indicated that a component within MLE may mediate its anti-inflammatory characteristics, as indicated by the increase in mRNA IL-37 expression in mice inoculated with &lt;em&gt;C. albicans&lt;/em&gt;. The highest increase in fungal load to 101.6 CFU was observed in the placebo group at day 14. Whereas for the mice treated with MLE at 750 mg/kg b.w, the fungal load only increased to 30.0 CFU, similar to that of mice treated with ketoconazole (29.6 CFU). In the mice treated with MLE at 500 mg/kg b.w, the fungal load increased to 68.2 CFU. &lt;strong&gt;Conclusion:&lt;/strong&gt;&amp;nbsp;Fungiostatic effect of MLE 750 mg/kg BB is not less than ketoconazole and MLE may act as anti-inflammatory throught its role as an antioxidant so it could potentially be used as an alternative treatment in humans especially patients with vulvovaginal candidiasis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">16</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Marni Karo&lt;sup&gt;1&lt;/sup&gt;, Mochammad Hatta&lt;sup&gt;2&lt;/sup&gt;*, WaOde Salma&lt;sup&gt;3&lt;/sup&gt;, Ilhamjaya Patellongi&lt;sup&gt;4&lt;/sup&gt;, Rosdiana Natzir&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Midwifey Program of Medistra Health Higher School, Jakarta. Indonesia andSchool of Post Graduate Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Molecular Biology and Immunology Laboratory for Infection Diseases, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt; 3&lt;/sup&gt;Department Nutrition, Faculty of Medicine, Halu Oleo University, Kendari, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biostatistic, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tetiana Derkach</style></author><author><style face="normal" font="default" size="100%">Volodymyr Khomenko</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Elemental Composition of the Medicinal Plants Hypericum perforatum, Urtica dioica and Matricaria chamomilla Grown in Ukraine: A Comparative Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Atomic absorption spectroscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Cd contamination</style></keyword><keyword><style  face="normal" font="default" size="100%">Elemental composition</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Pb</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/513</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">486-491</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To determine concentrations of essential microelements Fe, Cu, Mn and Zn, as well as toxic metals Pb, Cd, Cr and Co, in three herbal remedies and compare the experimental data obtained with available literature data. Materials and &lt;strong&gt;Methods:&lt;/strong&gt; Elemental compositions of three herbal remedies, Chamomile flowers, Urtica folia (nettle) and Hyperichi herba (St John&amp;rsquo;s wort), grown and produced in Ukraine, were studied by flame atomic absorption spectroscopy. &lt;strong&gt;Results:&lt;/strong&gt; The Fe concentration decreases, as well as the Zn and Mn concentrations, increase in going from nettle through chamomile to St John&amp;rsquo;s wort. The Cu content is virtually independent of the plant type. Statistically significant negative correlations between the element concentrations were found in Fe-Mn and Fe-Zn pairs. The studied samples of St John&amp;rsquo;s wort are more contaminated with Cd than other plants, while the highest Pb content is observed in some samples of nettle. &lt;strong&gt;Conclusion:&lt;/strong&gt; The measured levels of both Pb and Cd still secure against overuse of toxic metals with herbal remedies.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Medicinal plants, Atomic absorption spectroscopy, Elemental composition, Pb, Cd contamination.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">486</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Tetiana Derkach&lt;sup&gt;1*&lt;/sup&gt;, Volodymyr Khomenko&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Industrial Pharmacy, Kyiv National University of Technologies and Design, Nemyrovicha-Danchenko Str. 2, Kyiv, 01011, UKRAINE.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Electrochemical Energetics and Chemistry, Kyiv National University of Technologies and Design, Nemyrovicha-Danchenko Str. 2, Kyiv, 01011, UKRAINE.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Imane Chamkhi</style></author><author><style face="normal" font="default" size="100%">Laila Sbabou</style></author><author><style face="normal" font="default" size="100%">Jamal Aurag</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Endophytic Fungi Isolated from Crocus sativus L. (Saffron) as a Source of Bioactive Secondary Metabolites</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Crocus sativus L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Endophytic fungi</style></keyword><keyword><style  face="normal" font="default" size="100%">ITS rDNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Secondary metabolites</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1143-1148</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Endophytic fungi are becoming an important source of new natural bioactive products. Many interesting endophytic fungi have been isolated from traditional medicinal plants. &lt;em&gt;Crocus sativus&lt;/em&gt; L. (saffron) is one of the most expensive and rarest spices in the world, used as a dye, aroma and for medicinal purposes. This study reports on the molecular characterization of endophytic fungi isolated from roots of saffron plants growing in Taliouine- Morocco, and the examination of the antibacterial and antioxidant activities of secondary metabolites extracted from these endophytes. &lt;strong&gt;Methods and Material:&lt;/strong&gt; The fungi were isolated from sterilized saffron root fragments and identified using internal transcribed spacer (ITS) rRNA gene sequence analysis. Three endophytes were fermented and extracted with ethyl acetate (EtOAc) and chloroform (CHCl3). The antibacterial activity of fungi extracts was evaluated using the Agar Diffusion Method against six strains,&lt;em&gt; Bacillus&lt;/em&gt; &lt;em&gt;sp&lt;/em&gt;., &lt;em&gt;Stenotrophomonas sp., Pseudomonas putida, Pantoea sp., Luteibacter sp.&lt;/em&gt; and &lt;em&gt;Escherichia coli&lt;/em&gt;. The antioxidant activity was tested by using the &amp;alpha;,&amp;alpha;-diphenyl-&amp;beta;-picrylhydrazyl (DPPH) analysis and &amp;beta;-Carotene bleaching test (BCBT) methods. &lt;strong&gt;Results:&lt;/strong&gt; Sixty fungal isolates were recovered and purified from saffron roots. ITS rDNA sequences were 99-100% identical to three different species: Rhizopus oryzae, Aspergillus fumigatiaffinis and &lt;em&gt;Aspergillus niger. &lt;/em&gt;Both &lt;em&gt;Rhizopus oryzae&lt;/em&gt; extracts had high antibacterial activity against most of the bacteria tested, while &lt;em&gt;Aspergillus niger and Rhizopus oryzae&lt;/em&gt; extracts showed an antioxidant capacity using DPPH and BCBT methods, respectively.&lt;strong&gt; Conclusion:&lt;/strong&gt; The fungal endophytes inhabiting saffron roots could be a potential source of natural plant bioactive secondary metabolites especially for antibacterial and antioxidant purposes.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1143</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Imane Chamkhi*, Laila Sbabou, Jamal Aurag&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Microbiology and Molecular Biology Team, Center of Plant and Microbial Biotechnology, Biodiversity and Environment. Faculty of Sciences, Mohammed V University in Rabat, MOROCCO.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Victoria Vladimirovna Fedotova</style></author><author><style face="normal" font="default" size="100%">Dmitry Alexeevich Konovalov</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Essential Oil and Anatomical Study of Flowers Solidago caucasica Kem.-Nath.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chromoplasts</style></keyword><keyword><style  face="normal" font="default" size="100%">Humulene epoxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Pathulenol</style></keyword><keyword><style  face="normal" font="default" size="100%">Solidago caucasica Kem.-Nath.</style></keyword><keyword><style  face="normal" font="default" size="100%">Trichomes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s63-s65</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Plant &lt;em&gt;Solidago caucasica&lt;/em&gt; Kem.-Nath. (Asteraceae) is studied by us for the first time. We have established its diuretic and antimicrobial action. The study of essential oil and the anatomical structure of &lt;em&gt;S. caucasica&lt;/em&gt; flowers is presented for the first time in this article.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; &lt;em&gt;S. caucasica&lt;/em&gt; flowers were collected at the beginning of flowering in the botanical garden of the Pyatigorsk Medical and Pharmaceutical Institute. Essential oil was obtained by hydro distillation. The component composition of the essential oil was studied by liquid chromatography&amp;ndash;mass spectrometry. Results: The main components of essential oil and microscopic diagnostic signs of &lt;em&gt;S. caucasica&lt;/em&gt; flowers were established. &lt;em&gt;Solidago&lt;/em&gt; &lt;em&gt;caucasica&lt;/em&gt; flowers contain 0.57% essential oil. It contains humulene epoxide H (-)-spathulenol, &amp;beta;-linalool, &amp;alpha;-terpinol, trans-geraniol, carvacrol and others. Numerous pappus hairs meet in the microscopy of the flower. Ligulate florets are characterized by round chromoplasts, covering trichomes multicellular. Epidermal cells of the tubular florets have polygonal chromoplasts, trichomes, consisting of several cells fused with each other, covering trichomes with a thick wall and a thin cavity inside. On the epidermis of the involucre there are stomata of anomocytic type, glandular trichomes, trichomes cone-shaped, trichomes wide and essential oil glands. &lt;strong&gt;Conclusion:&lt;/strong&gt; The obtained standards will provide referential information for correct identification, purity, standardization and preparation of monograph of&lt;em&gt; S. caucasica&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s63</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Victoria Vladimirovna Fedotova, Dmitry Alexeevich Konovalov&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacognosy and Botany, Pyatigorsk Medical and Pharmaceutical Institute, A Branch of Volgograd State Medical University, Ministry of Health of Russian Federation, Pyatigorsk, 357532, Kalinina 11, RUSSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wilawan Promprom</style></author><author><style face="normal" font="default" size="100%">Wannachai Chatan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Estrogenic Effects of Euphorbia hirta L. Extract in Ovariectomized Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Estrogenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Euphorbia hirta L</style></keyword><keyword><style  face="normal" font="default" size="100%">Ovariectomized rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Uterus</style></keyword><keyword><style  face="normal" font="default" size="100%">Vagina.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/504</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">435-438.</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Euphorbia hirta&lt;/em&gt; L. has been wildly used for its health benefits. It has been used as a decoction and to treat diarrhea, peptic ulcers, menstrual problems and venereal diseases. &lt;strong&gt;Aims:&lt;/strong&gt; The study aims to investigate the estrogenic effects of &lt;em&gt;E. hirta&lt;/em&gt; on ovariectomized (OVX) rats. &lt;strong&gt;Methods:&lt;/strong&gt; The ovariectomized rats were divided into four groups, including those that received the vehicle (1% v/v Tween 80, p.o.), 17&amp;beta;-estradiol at a dose of 0.01 mg/kg B.W. and the ethanolic extract of &lt;em&gt;E. hirta&lt;/em&gt; at the doses of 100 and 500 mg/kg B.W. These were administered daily for 14 days. Estrogenic activity was determined by analyzing the body, vaginal and uterine weight as well as the uterine and vaginal histopathology characteristics of the estrogen-induced response. &lt;strong&gt;Results:&lt;/strong&gt; At the dose of 500 mg/kg B.W., the plant extract produced a significant increase in vaginal weight when compared with the ovariectomized rats, a slightly increase in the uterine weight and could induce hyperplastic epithelium and endometrial thickness of the vagina. &lt;strong&gt;Conclusion:&lt;/strong&gt; The data in this work suggests that the plant crude extract showed weak estrogenic effects in ovariectomized rats and could be useful for health benefits for vagina atrophy of females during the menopause.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Wilawan Promprom&lt;sup&gt;*&lt;/sup&gt;, Wannachai Chatan &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Biology, Faculty of Science, Mahasarakham University, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ourlad Alzeus G. Tantengco</style></author><author><style face="normal" font="default" size="100%">MARLON LIAN C. CONDES</style></author><author><style face="normal" font="default" size="100%">Hanna Hasmini T. Estadilla</style></author><author><style face="normal" font="default" size="100%">Elena M. Ragragio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Survey of Medicinal Plants used by Ayta Communities in Dinalupihan, Bataan, Philippines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ayta</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Philippines</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">859-870</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; This study documented the species of medicinal plants used by Ayta communities in Dinalupihan, Bataan. The plant parts used for medicinal purposes, preparations, mode of administration of these medicinal plants were determined. The most important species based on use values and informant consensus factors were also calculated.&lt;strong&gt; Methods:&lt;/strong&gt; A total of 26 informants were interviewed regarding the plants they utilize for medicinal purposes. Free and prior informed consents were obtained from the informants. Taxonomic identification was done in the Botany Division of the National Museum of the Philippines. Informant consensus factor (FIC) and use values (UV) were also calculated. &lt;strong&gt;Results:&lt;/strong&gt; Ayta communities listed a total of 118 plant species classified into 49 families used as herbal medicines. The Family &lt;em&gt;Fabaceae&lt;/em&gt; was the most represented plant family with 11 species. Leaves were the most used plant part (43%). Majority of medicinal preparations were taken orally (57%). It was found that &lt;em&gt;Psidium guajava L.&lt;/em&gt; and &lt;em&gt;Lunasia amara&lt;/em&gt; Blanco were the most commonly used medicinal plants in the three communities with the use value of 0.814. &lt;strong&gt;Conclusion:&lt;/strong&gt; This documentation provides a catalog of useful plants of the Ayta and serves as a physical record of their culture for the education of future Ayta generations.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">859</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ourlad Alzeus G. Tantengco&lt;sup&gt;1*&lt;/sup&gt;, Marlon Lian C. Condes&lt;sup&gt;2&lt;/sup&gt;, Hanna Hasmin T. Estadilla&lt;sup&gt;2&lt;/sup&gt;, Elena M. Ragragio&lt;sup&gt;2* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;College of Medicine, University of the Philippines Manila, Pedro Gil Street, Ermita, Manila City, Philippines, 1000&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, College of Arts and Sciences, University of the Philippines Manila, Padre Faura St., Ermita, Manila City, Philippines, 1000.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohd Saidur Rahman</style></author><author><style face="normal" font="default" size="100%">Md. Mujahid</style></author><author><style face="normal" font="default" size="100%">Mohd Aftab Siddiqui</style></author><author><style face="normal" font="default" size="100%">Md. Azizur Rahman,</style></author><author><style face="normal" font="default" size="100%">Muhammad Arif</style></author><author><style face="normal" font="default" size="100%">Shimaila Eram</style></author><author><style face="normal" font="default" size="100%">Anayatullah Khan</style></author><author><style face="normal" font="default" size="100%">Md Azeemuddin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Uses, Phytochemistry and Pharmacological Activities of Pterocarpus marsupium: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Epicatechin</style></keyword><keyword><style  face="normal" font="default" size="100%">Indian Kino</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Pterocarpus marsupium</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s1-s8</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;em&gt;Pterocarpus marsupium&lt;/em&gt; is an important therapeutic and medicinal plant belonging to family Fabaceae and commonly named as Indian Kino tree, Bijasal, Venga or Vijayasara. It is a huge deciduous plant and widely distributed in the Central, Western and Southern regions of India. Role of&lt;em&gt; P. marsupium&lt;/em&gt; is found in Ayurveda, Homeopathic and Unani systems of medicine. It is a decent source of tannins and flavonoids hence, used as influential astringent, anodyne, cooling, regenerating agent and also used for the treatments of leprosy, leucoderma, toothache, fractures, diarrhea, passive hemorrhage, and dysentery, bruises and diabetes. It is also used to treat rheumatoid arthritis, gout, diabetic anemia, indigestion, asthma, cough, discoloration of hair, bronchitis, ophthalmic complications, elephantiasis and erysipelas. Researchers have been stated the presence of several phytoconstituents in &lt;em&gt;P. marsupium&lt;/em&gt; and also their pharmacological activities. The current review aimed to define the phytochemical and pharmacological aspects of &lt;em&gt;P. marsupium&lt;/em&gt; which will have been help in the researchers for further qualitative research.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">s1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Mohd SaidurRahman, Md. Mujahid&lt;sup&gt;*&lt;/sup&gt;, Mohd Aftab Siddiqui, Md. Azizur Rahman, Muhammad Arif, Shimaila Eram, Anayatullah Khan, Md Azeemuddin&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Pharmacy, Herbal Bioactive Research Laboratory, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh -226026, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohamed Senouci Bereksi</style></author><author><style face="normal" font="default" size="100%">Hafida Hassaïne</style></author><author><style face="normal" font="default" size="100%">Chahrazed Bekhechi</style></author><author><style face="normal" font="default" size="100%">Djamel Eddine Abdelouahid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antibacterial Activity of some Medicinal Plants Extracts Commonly Used in Algerian Traditional Medicine against some Pathogenic Bacteria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacterial resistance</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydromethanolic extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibition zones</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">MICs</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/516</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">507-512</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The objective of this study was to evaluate the antibacterial activity of hydromethanolic extracts of &lt;em&gt;Berberis vulgaris&lt;/em&gt;, &lt;em&gt;Cassia angustifolia&lt;/em&gt;, &lt;em&gt;Cinnamomum cassia, Cistus monspeliensis, Nigella sativa, Punica granatum, Rhus tripartata, Withania frutescens and Zingiber officinale&lt;/em&gt; against different Gram-positive and Gram-negative reference bacterial strains. &lt;strong&gt;Methods:&lt;/strong&gt; The evaluation of antibacterial activity for different extracts of each plant was carried out using the disc diffusion method and determination of minimum inhibitory concentration (MIC). &lt;strong&gt;Results:&lt;/strong&gt; The plant extracts showed zone of inhibition ranging from 06.0 to 23.0 mm against one or more tested bacteria, and their efficacy in terms of MICs where ranged from 0.1 to 12.8 mg/mL. The Refluxed and Macerated extracts of these plants have shown relatively similar results in terms of diameters of inhibition and MICs. The extracts of &lt;em&gt;B. vulgaris, C. monspeliensis and P. granatum&lt;/em&gt; demonstrated relatively high activity as compared to the other plant extracts mainly against &lt;em&gt;S. aureus, E. faecalis and E. cloacae&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; Findings of this study indicate that hydromethanolic extracts of these plants have antibacterial activity against the different tested bacterial strains. This activity supports their use in treatment of infections caused by such resistant bacteria.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">507</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohamed Senouci Bereksi&lt;sup&gt;1*&lt;/sup&gt;, Hafida Hassa&amp;iuml;ne&lt;sup&gt;2&lt;/sup&gt;, Chahrazed Bekhechi&lt;sup&gt;1&lt;/sup&gt;, Djamel Eddine Abdelouahid&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Natural Products, Department of Biology, University of Tlemcen, 13000 Tlemcen, ALGERIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Applied Microbiology in Food, Biomedical and Environment, Department of Biology, University of Tlemcen, 13000 Tlemcen, ALGERIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohamed Senouci Bereksi</style></author><author><style face="normal" font="default" size="100%">Hafida Hassaïne</style></author><author><style face="normal" font="default" size="100%">Chahrazed Bekhechi</style></author><author><style face="normal" font="default" size="100%">Djamel Eddine Abdelouahid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antibacterial Activity of Some Medicinal Plants Extracts Commonly Used in Algerian Traditional Medicine against Some Pathogenic Bacteria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacterial resistance.</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydromethanolic extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibition zones</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">MICs</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">x</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">XX-XX</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The objective of this study was to evaluate the antibacterial activity of hydromethanolic extracts of &lt;em&gt;Berberis vulgaris, Cassia angustifolia, Cinnamomum cassia, Cistus monspeliensis, Nigella sativa, Punica granatum, Rhus tripartata, Withania frutescens and Zingiber officinale&lt;/em&gt; against different Gram-positive and Gram-negative reference bacterial strains. &lt;strong&gt;Methods:&lt;/strong&gt; The evaluation of antibacterial activity for different extracts of each plant was carried out using the disc diffusion method and determination of minimum inhibitory concentration (MIC). &lt;strong&gt;Results:&lt;/strong&gt; The plant extracts showed zone of inhibition ranging from 06.0 to 23.0 mm against one or more tested bacteria, and their efficacy in terms of MICs where ranged from 0.1 to 12.8 mg/mL. The Refluxed and Macerated extracts of these plants have shown relatively similar results in terms of diameters of inhibition and MICs. The extracts of &lt;em&gt;B. vulgaris, C. monspeliensis and P. granatum&lt;/em&gt; demonstrated relatively high activity as compared to the other plant extracts mainly against &lt;em&gt;S. aureus, E. faecalis and E. cloacae&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; Findings of this study indicate that hydromethanolic extracts of these plants have antibacterial activity against the different tested bacterial strains. This activity supports their use in treatment of infections caused by such resistant bacteria.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Medicinal plants, Hydromethanolic extracts, Antibacterial activity, Inhibition zones, MICs, Bacterial resistance.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2s</style></issue><work-type><style face="normal" font="default" size="100%">x</style></work-type><section><style face="normal" font="default" size="100%">XX</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohamed Senouci Bereksi&lt;sup&gt;1*&lt;/sup&gt;, Hafida Hassa&amp;iuml;ne&lt;sup&gt;2&lt;/sup&gt;, Chahrazed Bekhechi&lt;sup&gt;1&lt;/sup&gt;, Djamel Eddine Abdelouahid&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Natural Products, Department of Biology, University of Tlemcen, 13000 Tlemcen, ALGERIA. &lt;sup&gt;2&lt;/sup&gt;Laboratory of Applied Microbiology in Food, Biomedical and Environment, Department of Biology, University of Tlemcen, 13000 Tlemcen, ALGERIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lubna Azmi</style></author><author><style face="normal" font="default" size="100%">Ila Shukla</style></author><author><style face="normal" font="default" size="100%">Shyam Sundar Gupta</style></author><author><style face="normal" font="default" size="100%">Aniruddh Chaudhary</style></author><author><style face="normal" font="default" size="100%">Padam Kant</style></author><author><style face="normal" font="default" size="100%">Narayan Prasad Yadav</style></author><author><style face="normal" font="default" size="100%">Chandana Venkateswara Rao</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Chemoprotective Effect of Quercetin from Argyreia speciosa against N-methyl-N-Nitro-N-Nitrosoguanidine and NaCl-Induced Gastric Carcinomas in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Argyreia speciosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastric carcinoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/467</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">215-220</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; This study was carried out to investigate the chemo protective potential of Quercetin, an isolated compound from &lt;em&gt;Argyreia speciosa&lt;/em&gt;, on N-methyl-N-nitro-N-nitrosoguanidine and NaCl-induced gastric carcinomas in Wistar rats. &lt;strong&gt;Methods:&lt;/strong&gt; The rats were fed with a diet supplemented with 8% NaCl and simultaneously given N-methyl-N-nitro-N-nitrosoguanidine. After administration of the carcinogen, quercetin was administered. The whole stomach and a part of duodenum were sampled, cut open and tumors were recorded. The specimens were histopathologically investigated and the expression of surviving was examined with immunohistochemical analysis.&lt;strong&gt; Results and Conclusions:&lt;/strong&gt; The treatment with quercetin significantly increases body weight in the rats after N-methyl-N-nitro-N-nitrosoguanidine administration. Survivin expression in glandular stomachs of normal rats, of rats in adenocarcinomas and quercetin at dose dependent manner treated rats were 0%, 90%, 75%, 33.3-25%, respectively. Compared with the survivin expression in negative rats, the differences were significant. Compared with the survivin expression in normal rats, the differences were significant. Histological observations of stomach tissues too correlated with the biochemical observations. These findings indicated that the Quercetin treatment could stimulate immunity activity in rats with N-methyl-N-nitro-N-nitrosoguanidine induced gastric carcinoma and have pronounced effect on survivin which is an attractive target for gastric cancer therapy.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">215</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Lubna Azmi &lt;sup&gt;1,2&lt;/sup&gt;, Ila Shukla&lt;sup&gt;1&lt;/sup&gt;, Shyam Sundar Gupta&lt;sup&gt;1&lt;/sup&gt;, Aniruddh Chaudhary&lt;sup&gt;2&lt;/sup&gt;, Padam Kant&lt;sup&gt;2&lt;/sup&gt;, Narayan Prasad Yadav&lt;sup&gt;3&lt;/sup&gt;, Chandana Venkateswara Rao&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow, Uttar Pradesh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, University of Lucknow, Lucknow, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Botany and Pharmacognosy Department, CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lorina Ineta Badger-Emeka</style></author><author><style face="normal" font="default" size="100%">Hany Ezzat Khalil</style></author><author><style face="normal" font="default" size="100%">Promise Madu Emeka</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Different Fractions of Garcinia kola Extracts against Multidrug Resistant Clinical Bacterial and Fungal Isolates</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Clinical isolates</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia kola</style></keyword><keyword><style  face="normal" font="default" size="100%">Minimum inhibitory concentration</style></keyword><keyword><style  face="normal" font="default" size="100%">Multidrug resistant bacteria</style></keyword><keyword><style  face="normal" font="default" size="100%">Sensitivity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1055-1060</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The effectiveness of antibiotics used in the treatment of bacterial infections has been on the decline due to bacterial resistance. To improve clinical management of recalcitrant bacterial infections, alternative therapy such as medicinal plant products are now being evaluated. This study investigates the antimicrobial effects of &lt;em&gt;Garcinia kola&lt;/em&gt; fractions on clinical isolates of multidrug resistant gram negative bacteria and Candida. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; &lt;em&gt;Escherichia coli&amp;nbsp;&lt;/em&gt;, &lt;em&gt;Acinetobacter baumannii&lt;/em&gt;, &lt;em&gt;Serratia marcescens&lt;/em&gt; and &lt;em&gt;Candida species&lt;/em&gt; were used for the study. Microbial isolation and antimicrobial susceptibility test was carried out using basic microbiological procedures. Confirmation of all isolates was done using the VITEK 2 compact automated system (BioMerieux, Marcy I&amp;rsquo;Etoile France). The powdered dried seeds of&lt;em&gt; G. kola&lt;/em&gt; were extracted with 70% methanol for 7 days, using a cold maceration method. The crude extracts were evaporated to dryness, using different solvents to obtain the fractions according to standard fractionation techniques. &lt;strong&gt;Results:&lt;/strong&gt; The aqueous, butanol, chloroform and hexane fractions at minimum inhibitory concentrations (MIC) of 25mg/ml were active against &lt;em&gt;A. baumannii&lt;/em&gt;. Ethyl acetate fraction at MIC of 20 mg/ml also produced growth inhibition of same isolates. At the same MICs, the different fractions were observed to inhibit the growth of candida albicans (CF1) isolate. Overall, aqueous fraction of &lt;em&gt;G. kola&lt;/em&gt; produced more growth inhibition followed by butanol fractions, with chloroform fractions producing the least effects. &lt;strong&gt;Conclusion:&lt;/strong&gt; The antibacterial potencies of these extracts could be useful for the treatment of multi-drug-resistant&lt;em&gt; A. baumannii&lt;/em&gt;. The aqueous fraction showed better activities than the other fractions studied.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1055</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Lorina Ineta Badger-Emeka&lt;sup&gt;1&lt;/sup&gt;*, Hany Ezzat Khalil&lt;sup&gt;2&lt;/sup&gt;, Promise Madu Emeka&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biomedical Sciences, College of Medicine, King Faisal University. Al-Ahsa, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Asiya Ramzan</style></author><author><style face="normal" font="default" size="100%">Inayatullah Tahir</style></author><author><style face="normal" font="default" size="100%">Reiaz Ul Rehman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of in vitro Antioxidant Potential of Amaranthus caudatus L. Grown in Kashmir Region</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amaranthus</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrogen peroxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolics</style></keyword><keyword><style  face="normal" font="default" size="100%">Reactive Oxygen Species</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxide dismutase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1119-1124</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Plants have a well-developed defensive machinery for minimizing the reactive oxygen species (ROS) associated damages in the form of enzymatic and nonenzymatic antioxidants. The &lt;em&gt;in-vitro&lt;/em&gt; mechanism of antioxidant action of plant extracts may involve direct inhibition of the ROS generation or ROS scavenging. The antioxidant activity of the extracts may be due to active constituents alone or the combination of constituents. However, the amount of constituents are known to vary according to the change in environment. &lt;strong&gt;Method:&lt;/strong&gt; In our study, antioxidant activity of &lt;em&gt;Amaranthus caudatus&lt;/em&gt; L. from two different sites (elevation sites) was investigated at three stages, (vegetative, pre flowering and post flowering) using ethanolic extract (EtOH). &lt;strong&gt;Result:&lt;/strong&gt; The phenolic and flavonoid content increased at all stages from site 1 to site 2. The total reducing power, Ferrous reducing antioxidative power (FRAP), diphenyl picryl hydrazine (DPPH) radical scavenging assay, superoxide dismutase scavenging (SOD) assay and hydrogen peroxide (H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;) scavenging activity increased from site 1 to site 2 at all the three stages. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results reveal that the altitude and the growth stage have a significant effect on antioxidative potential of&lt;em&gt; Amaranthus.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1119</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Asiya Ramzan&lt;sup&gt;1&lt;/sup&gt; Inayatullah Tahir&lt;sup&gt;2&lt;/sup&gt; Reiaz Ul Rehman&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Bioresources, University of Kashmir, Srinagar, Jammu and Kashmir- 190006, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, University of Kashmir, Srinagar, Jammu and Kashmir- 190006, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">María C. Flechas</style></author><author><style face="normal" font="default" size="100%">Raquel E. Ocazionez</style></author><author><style face="normal" font="default" size="100%">Elena E. Stashenko</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of in vitro Antiviral Activity of Essential Oil Compounds Against Dengue Virus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral</style></keyword><keyword><style  face="normal" font="default" size="100%">Dengue</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavivirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpene</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/366</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">55-59</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; There are not effective drugs available for treatment of dengue fever despite intensive research on synthetic inhibitors. The search for active phytochemicals could serve for the discovery of new drugs. This study aims to evaluate the antiviral activity&lt;em&gt; in vitro&lt;/em&gt; of compounds found in essential oils from medicinal plants. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Nine synthetic-derived essential oil compounds were evaluated. Antiviral effect was screened measuring the reduction of viral NS1 and E proteins in HepG-2 and Vero cells. Results: &amp;beta;-Caryophyllene was identified as the most active compound, it reduced the virus serotype-2 replication in HepG-2 cells at IC&lt;sub&gt;50&lt;/sub&gt; of 22 &amp;plusmn; 5.6 &amp;mu;M, and blocked replication of all four serotypes in Vero cells at IC&lt;sub&gt;50&lt;/sub&gt; between 8.0 &amp;mu;M and 15.0 &amp;mu;M. The selectivity indexes were between 5.3 and 10. According to results from time-in-addition assays, the antiviral effect of &amp;beta;-caryophyllene appears to be associated with interruption of early steps of the virus life cycle. Citral revealed modest antiviral effect, it reduced the virus serotype-2 (IC&lt;sub&gt;50&lt;/sub&gt; of 31 &amp;plusmn; 4.5 &amp;mu;M) replication but not the other three serotypes. Seven terpenes did not reveal antiviral activity at maximum concentration of 30 &amp;mu;M. &lt;strong&gt;Conclusion:&lt;/strong&gt; Research on compounds found in essential oils can contribute to the drug discovery effort for dengue. &amp;beta;-Caryophyllene could serve as a starting point.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">55</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Mar&amp;iacute;a C. Flechas, Raquel E. Ocazionez*, Elena E. Stashenko &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Centro de Investigaciones en Enfermedades Tropicales (CINTROP) and Centro de Investigaci&amp;oacute;n en Biomol&amp;eacute;culas (CIBIMOL), Universidad Industrial de Santander, Bucaramanga, COLOMBIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vyshnavi, Gayathri Rao</style></author><author><style face="normal" font="default" size="100%">Shyamala Nayak</style></author><author><style face="normal" font="default" size="100%">Beena Shetty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Modulatory Effect of Combination of Spondias Pinnata and Whey Preparation on Intestinal Antioxidants and Inflammatory Markers in Etoposide Induced Rat Model for Mucositis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Etoposide</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation (LPO)</style></keyword><keyword><style  face="normal" font="default" size="100%">Mucositis</style></keyword><keyword><style  face="normal" font="default" size="100%">Myeloperoxidase (MPO)</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric Oxide (NO)</style></keyword><keyword><style  face="normal" font="default" size="100%">Spondias pinnata</style></keyword><keyword><style  face="normal" font="default" size="100%">Whey preparation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/643</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">640-644</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of human cancers. The efficacy of this drug is often limited due to severe sideeffects such as mucositis, anorexia, myelosupperssion, alopecia. At present there are no anti-mucositic agents without side effects. To combat these side effects of cancer treatment, innovative and specific nutritional interventions are needed. The experimental procedure included an oral treatment with combination of &lt;em&gt;Spondias pinnata&lt;/em&gt; and whey preparation (100 mg/kg b.w).on etoposide induced mucositis. &lt;strong&gt;Methods:&lt;/strong&gt; Study was conducted at Central Research Laboratory, Kasturba Medical College. Rats were sacrificed by cervical dislocation and duodenum collected for estimation of biochemical parameters. Estimation was carried out for assessing the levels of TAO, GSH, LPO, NO and activity of MPO. Correlation analysis was performed by one-way Anova using graph pad prism to find the relation between control and test. Result: The antioxidant (TAO and GSH) were found to be significantly high in the rats which received the combination compared to the individual &lt;em&gt;Spondias pinnata&lt;/em&gt; and whey treated groups. Administration &lt;em&gt;Spondias pinnata&lt;/em&gt; and whey in combination shows significant decrease in the TBARS, NO and MPO levels. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Spondias pinnata&lt;/em&gt; and whey preparation supplementation in combination have shown mucoprotective effects in rat model. Hence it can be considered as anti-mucositis therapeutic agents which can be safely administered during chemotherapy and can reverse mucositis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">640</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Vyshnavi, Gayathri Rao*, Shyamala Nayak, Beena Shetty &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Mangaluru, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shcherbakova Ekaterina Aleksandrovna</style></author><author><style face="normal" font="default" size="100%">Eliseeva Lyudmila Mikhailovna</style></author><author><style face="normal" font="default" size="100%">Konovalov Dmitry Alexeevich</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Experience of Introduction of Two Species of Eryngium in the North Caucasus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Eryngium</style></keyword><keyword><style  face="normal" font="default" size="100%">Eryngium caucasicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Eryngium plan</style></keyword><keyword><style  face="normal" font="default" size="100%">Introduction</style></keyword><keyword><style  face="normal" font="default" size="100%">Recommendations</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s59-s62</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The article gives recommendations on the cultivation of &lt;em&gt;Eryngium caucasicum&lt;/em&gt; Trautv. and E&lt;em&gt;ryngium planum&lt;/em&gt; L. in the Caucasus. &lt;strong&gt;Introduction:&lt;/strong&gt; In Russia, grows about 20 species of Eryngium, in the Caucasus - 8 species. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The subjects of the study were two species: &lt;em&gt;Eryngium caucasicum&lt;/em&gt; Trautv. and &lt;em&gt;Eryngium planum&lt;/em&gt; L. The main methods of research: field, observation, mathematical. &lt;strong&gt;Results:&lt;/strong&gt; The seedlings appear on the 14-16th day. In the first year of vegetation, a rosette of leaves is formed. In September, the rosettes of leaves have a diameter of 35-39 cm. Plants of the second year of vegetation pass through all phases of development: &lt;em&gt;Eryngium caucasicum&lt;/em&gt; Trautv. - for 180 days, &lt;em&gt;Eryngium planum&lt;/em&gt; L. - for 160 days. &lt;strong&gt;Conclusion:&lt;/strong&gt; Seeds should be sown in late autumn (late October - early November) or early spring (late February - beginning of March). Seeds are sown to a depth of 1-2 cm, between rows - 50-60 cm. Care of plants requires weeding from weeds and watering. Collection of seeds and fruits is recommended in August - September.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s59</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shcherbakova Ekaterina Aleksandrovna, Eliseeva Lyudmila Mikhailovna, Konovalov Dmitry Alexeevich&lt;sup&gt;*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacognozy and botany, Pyatigorsk Medical and Pharmaceutical Institute, a branch of Volgograd State Medical University Ministry of Health of the Russian Federation, Pyatigorsk, 357532, Kalinina av.11, RUSSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shaswat Ojha</style></author><author><style face="normal" font="default" size="100%">Adarsha Raj</style></author><author><style face="normal" font="default" size="100%">Alokesh Roy</style></author><author><style face="normal" font="default" size="100%">Sudipta Roy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extraction of Total Phenolics, Flavonoids and Tannins from Paederia foetida L. Leaves and their Relation with Antioxidant Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Extraction conditions</style></keyword><keyword><style  face="normal" font="default" size="100%">Fresh and shade dried leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Paederia foetida</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/521</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">541-547</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Paederia foetida&lt;/em&gt; L. is a climbing shrub that possesses several ethnomedicinal uses with immense pharmacologic relevance. &lt;strong&gt;Objective:&lt;/strong&gt; The study aims to determine an efficient extraction condition for phenolic compounds with substantial antioxidant activity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Solvent (aqueous, methanol, ethanol and acetone) extracts were made from fresh leaves (FL) and shade dried leaves (SDL) of &lt;em&gt;P. foetida&lt;/em&gt; with different durations (12, 24, 36 and 48 h). Quantitative estimations of all extracts were made for total phenolic content (TPC), total flavonoid content (TFC) and total tannin content (TTC) along with their total antioxidant activity (TAA). The phenolic contents of different extracts were correlated with their TAA. Extracts with highest phenolic yield and TAA estimates for each solvent were assessed by 2, 2-diphenyl-1-picrylhydrazyl (DPPH), 2, 2ˊ-azinobis-3-ethylbenzthiazoline-6- sulfonic acid (ABTS), superoxide (SO) and ferric reducing antioxidant power (FRAP) assays. &lt;strong&gt;Results:&lt;/strong&gt; Methanol exhibited the highest extraction ability for TPC, TFC and TAA while aqueous extractions are superior for TTC. The maximum estimates of all the studied components are noted at 48 h. Mostly, extracts of SDL are superior to FL. TPC and TFC are interrelated between themselves as well as showed positive and significant correlation with TAA. The antioxidant assays (DPPH, ABTS, SO and FRAP) reveal higher antioxidant activity with methanolic extracts compared to other studied solvents. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study highlights antioxidant properties of phenolics, particularly flavonoids in &lt;em&gt;P. foetida&lt;/em&gt;, which can be further explored for its pharmacological importance.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">541</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shaswat Ojha, Adarsha Raj, Alokesh Roy, Sudipta Roy&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Botany, University of Kalyani, Kalyani 741235, Nadia, West Bengal, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shaswat Ojha</style></author><author><style face="normal" font="default" size="100%">Adarsha Raj</style></author><author><style face="normal" font="default" size="100%">Alokesh Roy</style></author><author><style face="normal" font="default" size="100%">Sudipta Roy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extraction of Total Phenolics, Flavonoids and Tannins from Paederia foetida L. Leaves and their Relation with Antioxidant Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Extraction conditions</style></keyword><keyword><style  face="normal" font="default" size="100%">Fresh and shade dried leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Paederia foetida</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">x</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">XX-XX</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Paederia foetida&lt;/em&gt; L. is a climbing shrub that possesses several ethnomedicinal uses with immense pharmacologic relevance. &lt;strong&gt;Objective:&lt;/strong&gt; The study aims to determine an efficient extraction condition for phenolic compounds with substantial antioxidant activity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Solvent (aqueous, methanol, ethanol and acetone) extracts were made from fresh leaves (FL) and shade dried leaves (SDL) of &lt;em&gt;P. foetida&lt;/em&gt; with different durations (12, 24, 36 and 48 h). Quantitative estimations of all extracts were made for total phenolic content (TPC), total flavonoid content (TFC) and total tannin content (TTC) along with their total antioxidant activity (TAA). The phenolic contents of different extracts were correlated with their TAA. Extracts with highest phenolic yield and TAA estimates for each solvent were assessed by 2, 2-diphenyl-1-picrylhydrazyl (DPPH), 2, 2ˊ-azinobis-3-ethylbenzthiazoline-6- sulfonic acid (ABTS), superoxide (SO) and ferric reducing antioxidant power (FRAP) assays. &lt;strong&gt;Results:&lt;/strong&gt; Methanol exhibited the highest extraction ability for TPC, TFC and TAA while aqueous extractions are superior for TTC. The maximum estimates of all the studied components are noted at 48 h. Mostly, extracts of SDL are superior to FL. TPC and TFC are interrelated between themselves as well as showed positive and significant correlation with TAA. The antioxidant assays (DPPH, ABTS, SO and FRAP) reveal higher antioxidant activity with methanolic extracts compared to other studied solvents. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study highlights antioxidant properties of phenolics, particularly flavonoids in &lt;em&gt;P. foetida&lt;/em&gt;, which can be further explored for its pharmacological importance.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Antioxidants, Extraction conditions, Fresh and shade dried leaves, &lt;em&gt;Paederia foetida&lt;/em&gt;, Polyphenols.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2s</style></issue><work-type><style face="normal" font="default" size="100%">x</style></work-type><section><style face="normal" font="default" size="100%">XX</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shaswat Ojha, Adarsha Raj, Alokesh Roy, Sudipta Roy&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Botany, University of Kalyani, Kalyani 741235, Nadia, West Bengal, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anies Monica Adhitia</style></author><author><style face="normal" font="default" size="100%">Alisa Nur Octaviani</style></author><author><style face="normal" font="default" size="100%">Rissyelly</style></author><author><style face="normal" font="default" size="100%">Katrin Basah</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Gamma Irradiation on Angiotensin Converting Enzyme Inhibition, Antioxidant Activity, Total Phenolic Compound and Total Flavonoid of Peperomia pellucida Herbs Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ACE</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Gamma-irradiation</style></keyword><keyword><style  face="normal" font="default" size="100%">Peperomia pellucida</style></keyword><keyword><style  face="normal" font="default" size="100%">Total flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/308</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">244-248</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Peperomia pellucida&lt;/em&gt; L. Kunth has been reported to have some biological activities such as antihypertensive and antioxidants. Herbal materials susceptible to contamination during processing and storage which can shortens their shelf life. Gamma-irradiation has been used as a method for preservation. &lt;strong&gt;Methods:&lt;/strong&gt; This research aimed to analyze the effect of gamma-irradiation on inhibition activity of angiotensin converting enzyme (ACE), antioxidant activity, total phenol content, total flavonoid, and thin layer chromatography profiles of &lt;em&gt;P. pellucida&lt;/em&gt; L. Herbs extract. The extract was irradiated with 60Co gamma rays at 2.5; 5; 7.5; dan 10 kGy. &lt;strong&gt;Results:&lt;/strong&gt; Irradiation up to 10 kGy did not change ACE inhibitory activity and TLC profile. No significant differences were noted in the inhibition activity of ACE and the type of chromatogram profiles between non-irradiated extract and irradiated extracts up to a dose of 10 kGy while total flavonoids showed a significant decrease. In addition, total phenolic content and antioxidant activity showed a significant increase of extracts were irradiated up to 5 kGy and decrease at dose 7,5 kGy and 10 kGy. Gamma-irradiation up to 10 kGy didn&amp;rsquo;t affect the activity of ACEinhibitor &lt;em&gt;in-vitro&lt;/em&gt; while significant difference (P &amp;lt;0.05) of antioxidant activity, total flavonoids and phenolic content of the extract &lt;em&gt;P. Pellucida&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; In conclusion, gamma - irradiation can be used as a preservation method for ethanol extract &lt;em&gt;P. Pellucida&lt;/em&gt; L. Kunth herbs.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">244</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Anies Monica Adhitia, Alisa Nur Octaviani, Rissyelly, Katrin Basah, Abdul Mun&amp;rsquo;im* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Kampus Baru UI Depok 16424, Depok, Indonesia.&amp;nbsp;&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mubarika Sekarsari Yusuf</style></author><author><style face="normal" font="default" size="100%">Intan Wulandari</style></author><author><style face="normal" font="default" size="100%">Lili Amelia</style></author><author><style face="normal" font="default" size="100%">Katrin</style></author><author><style face="normal" font="default" size="100%">Arikadia Noviani</style></author><author><style face="normal" font="default" size="100%">Rissyelly</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Gamma Irradiation on Suruhan (Peperomia pellucida (L.) Kunth) Herb Powder</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Angiotensin converting enzyme</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Peperomia pellucida</style></keyword><keyword><style  face="normal" font="default" size="100%">total flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/307</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">239-243</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Peperomia pellucida&lt;/em&gt; (L.) Kunth is known as a raw material for herbal medicine; Preservation of herbs powder by gamma irradiation is reported to be able to keep products free from contamination. &lt;strong&gt;Methods:&lt;/strong&gt; This study aims to evaluate the effect of gamma irradiation (0; 2.5; 5; 7.5; and 10 kGy) on the ACE inhibitory activity (ACE Kit &amp;ndash; WST test kit method), antioxidant activity (DPPH radical scavenging method), total phenolic content (colorimetric method using Folin-Ciocalteu reagent), total flavonoid content (colorimetric method using AlCl3 and sodium acetate), and TLC profiling (silica gel F&lt;sub&gt;254&lt;/sub&gt; as the stationary phase and dichlormethane:methanol [92:8] as the mobile phase) of suruhan herb powder. &lt;strong&gt;Results:&lt;/strong&gt; Results showed that the 2.5 kGy irradiation dose gave the smallest alteration in ACE inhibitory activity compared to others irradiated doses. Furthermore, the 5 and 7.5 kGy dose didn&amp;rsquo;t cause significant change (p&amp;gt;0.05) on antioxidant activity, total phenolic content, and total flavonoid content. Antioxidant activity was found to correlate with the total phenolic content but not with the total flavonoid content. &lt;strong&gt;Conclusion:&lt;/strong&gt; Based on these finding, it is concluded that gamma irradiation can be used as a preservation method for &lt;em&gt;P. pellucida&lt;/em&gt; herb powder.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">239</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mubarika Sekarsari Yusuf, Intan Wulandari, Lili Amelia, Katrin, Arikadia Noviani, Rissyelly, Abdul Mun&amp;rsquo;im* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Kampus Baru UI Depok, Jawa Barat, 16424, Indonesia&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Daniel Rodrigo Cavalcante de Araújo</style></author><author><style face="normal" font="default" size="100%">Luís Cláudio Nascimento da Silva</style></author><author><style face="normal" font="default" size="100%">Wolfgang Harand</style></author><author><style face="normal" font="default" size="100%">Júlia Morais Fernandes</style></author><author><style face="normal" font="default" size="100%">Thaciane da Cunha Soares</style></author><author><style face="normal" font="default" size="100%">Silvana Maria Zucolotto Langassner</style></author><author><style face="normal" font="default" size="100%">Raquel Brandt Giordani</style></author><author><style face="normal" font="default" size="100%">Rafael Matos Ximenes</style></author><author><style face="normal" font="default" size="100%">Alexandre Gomes da Silva</style></author><author><style face="normal" font="default" size="100%">Márcia Vanusa da Silva</style></author><author><style face="normal" font="default" size="100%">Maria Tereza dos Santos Correia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Rainfall on the Antimicrobial Activity and Secondary Metabolites Contents of Leaves and Fruits of Anadenanthera colubrina from Caatinga Area.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword><keyword><style  face="normal" font="default" size="100%">Semi arid area</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.73</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">435-440</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Anadenanthera colubrina&lt;/em&gt; (Vell.) Brenan var. cebil (Griseb) is a plant widely used for medicinal proposes in Brazilian Northeast. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to analyze the influence of rainfall indexes (RI) in antimicrobial activity and phytochemical constituents of extracts from leaves and fruits of&lt;em&gt; A. colubrina&lt;/em&gt;. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Samples were collected in Catimbau National Park (Bu&amp;iacute;que, Pernambuco, Brazil) at September 2010 (RI: 75 mm) and January (RI: 65 mm), April (RI: 162 mm) and June 2011 (RI: 73 mm). The extracts were prepared by Soxhlet extraction using cyclohexane, chloroform, ethyl acetate and methanol. The antimicrobial activity was determined by MIC and MBC values. &lt;strong&gt;Results:&lt;/strong&gt; All extracts showed antimicrobial activity, but ethyl acetate extracts (from all periods) were more active. Strong correlations were found between the RI and the average MIC of MLE (&amp;rho;: -0.99), EALE (&amp;rho;: -0.81), CHFE (&amp;rho;: -0.81), EAFE (&amp;rho;: -0.80); while moderate and weak correlations were found for other extracts. Through a HPLC analysis was possible to reveal that the samples collected from dry periods had more chemical diversity (as they presented more peaks). Gallic acid and quercetin (and derivative compounds) were identified. The levels of quercetin were enhanced in extracts from dry months. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our results showed that the rainfall has a positive effect on the antimicrobial activity of leaves and fruits of A. &lt;em&gt;colubrina&lt;/em&gt;, however these extracts showed more chemical diversity during dry months.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Daniel Rodrigo Cavalcante de Ara&amp;uacute;jo&lt;sup&gt;1&lt;/sup&gt;, Lu&amp;iacute;s Cl&amp;aacute;udio Nascimento da Silva&lt;sup&gt;2&lt;/sup&gt;, Wolfgang Harand&lt;sup&gt;3&lt;/sup&gt;, J&amp;uacute;lia Morais Fernandes&lt;sup&gt;4&lt;/sup&gt;, Thaciane da Cunha Soares&lt;sup&gt;4&lt;/sup&gt;, Silvana Maria Zucolotto Langassner&lt;sup&gt;4&lt;/sup&gt;, Raquel Brandt Giordani&lt;sup&gt;4&lt;/sup&gt;, Rafael Matos Ximenes&lt;sup&gt;5&lt;/sup&gt;, Alexandre Gomes da Silva&lt;sup&gt;1&lt;/sup&gt;, M&amp;aacute;rcia Vanusa da Silva&lt;sup&gt;1&lt;/sup&gt;, Maria Tereza dos Santos Correia&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laborat&amp;oacute;rio de Produtos Naturais, Departamento de Bioqu&amp;iacute;mica, Universidade Federal de Pernambuco, Pernambuco, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Programa de Mestrado em Biologia Parasit&amp;aacute;ria, Universidade CEUMA, Maranh&amp;atilde;o, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laborat&amp;oacute;rio de Fitoqu&amp;iacute;mica, Instituto Nacional do Semi-&amp;Aacute;rido (INSA), Para&amp;iacute;ba, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Farm&amp;aacute;cia, Universidade Federal do Rio Grande do Norte, Rio Grande do Norte, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Antibi&amp;oacute;ticos, Universidade Federal de Pernambuco, Pernambuco, BRASIL.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Astrid Tilaar</style></author><author><style face="normal" font="default" size="100%">Anna Ranti</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Efficacy Study of Snake Fruit (Salacca edulis Reinw Var. Bongkok) Extract as Skin Lightening Agent</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Melanin index</style></keyword><keyword><style  face="normal" font="default" size="100%">Salacca edulis Reinw</style></keyword><keyword><style  face="normal" font="default" size="100%">Snake fruit extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Tyrosinase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/306</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">235-238</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The whitening skin product market has been growing significantly in Asia Pacific. Indonesia is one of those countries that mainly think that having a white color skin is simply beautiful. Therefore, it motivates Indonesian women to buy more whitening product for their beauty needs. &lt;strong&gt;Objective:&lt;/strong&gt; The purpose of this research is to find raw material for whitening product from Indonesian plants that can be useful as skin lightening agents. This study investigated the potential of snake fruit (&lt;em&gt;Salacca edulis&lt;/em&gt; Reinw var. Bongkok) ethanolic extract as skin lightening agent. Fruits of &lt;em&gt;Salacca edulis&lt;/em&gt; Reinw contains flavonoids which have been reported to play a part in skin depigmentation. &lt;strong&gt;Methods:&lt;/strong&gt; A randomized double-blind study on 17 human volunteers showed marked skin lightening effects using cream containing 3% extract as there was a significant reduction in skin melanin index which compared favorably with the base cream (p &amp;lt;0,05). &lt;strong&gt;Results:&lt;/strong&gt; The result strongly suggested that snake fruit ethanolic extract can be used as raw material for skin lightening agents and therefore Indonesia dependency on imported raw materials could be reduced.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">235</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Astrid Tilaar&lt;sup&gt;1,2&lt;/sup&gt;, Anna Ranti&lt;sup&gt;2&lt;/sup&gt;, Abdul Mun&amp;rsquo;im&lt;sup&gt;1&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Martha Tilaar Innovation Centre, Jakarta, Indonesia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ankita Misra</style></author><author><style face="normal" font="default" size="100%">Akanksha Srivastava</style></author><author><style face="normal" font="default" size="100%">Mohammad Khalid</style></author><author><style face="normal" font="default" size="100%">Poonam Kushwaha</style></author><author><style face="normal" font="default" size="100%">Sharad Srivastava</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti Arthritic Potential of Gloriosa superba (L.) Elite Germplasm Collected from Eastern Himalayas, India</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti arthritic</style></keyword><keyword><style  face="normal" font="default" size="100%">Colchicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Elite chemotype</style></keyword><keyword><style  face="normal" font="default" size="100%">G. superba</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/387</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">s87-s92</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Gloriosa superba&lt;/em&gt; (L.) is a traditionally known medicinal plant for its potential antigout property. The species is rich source of colchicine alkaloid and is commercially exploit in the international market for the same. &lt;strong&gt;Method:&lt;/strong&gt; In the present study, elite chemotype of &lt;em&gt;G. superba&lt;/em&gt; was identified from natural population in Eastern Himalayas based on their colchicine content through HPTLC calibrated method. The selected elite chemotypes were further evaluated for &lt;em&gt;in vitro&lt;/em&gt; anti-arthritic potential via inhibition of protein denaturation along with hydroxyl radical scavenging potential. &lt;strong&gt;Result:&lt;/strong&gt; The HPTLC quantification data reveals that the content of colchicine varies from 0.044 to 0.184% having maximum content in NBG-128 from Jorhat, Assam. The results of bioassay reflect a potentiating anti-arthritic and hydroxyl radical scavenging with statistically insignificant difference within the elite germplasms. &lt;strong&gt;Conclusion:&lt;/strong&gt; The presence of bioactive polyphenolics with significant hydroxyl radical scavenging will further suggest that inhibition of inflammatory mediator cells by extract is superimposed action of colchicine and other chemical inhibitors like polyphenolics. The study will aid in site specific exploration of high metabolite yielding chemotype(s) with validated pharmacological action for commercial cultivation to meet out the industrial demand of colchicine and herbal product development.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s87</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ankita Misra&lt;sup&gt;1,2,&lt;/sup&gt; Akanksha Srivastava&lt;sup&gt;1&lt;/sup&gt;, Mohammad Khalid&lt;sup&gt;2&lt;/sup&gt;, Poonam Kushwaha&lt;sup&gt;2&lt;/sup&gt;, Sharad Srivastava&lt;sup&gt;1&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow, Uttar Pradesh 226001, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh 226001, INDIA.&amp;nbsp;&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Divneet Kaur</style></author><author><style face="normal" font="default" size="100%">Richa Shri</style></author><author><style face="normal" font="default" size="100%">Anjoo Kamboj</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti-Anxiety Effect of Brassica oleracea L. Extracts in Experimental Animals</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antianxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Brassica oleracea</style></keyword><keyword><style  face="normal" font="default" size="100%">Elevated Plus Maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Hole Board</style></keyword><keyword><style  face="normal" font="default" size="100%">Mirror Chamber Test</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/pj-9-5/10.5530pj.2017.5.101/index.html</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">638-643</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Oxidative stress in the brain causes nervous system impairment. Hence the use of antioxidants could be an effective approach to prevent disorders such as anxiety. Plants containing phenolic constituents are reported to be potent antioxidants. &lt;em&gt;Brassica oleracea&lt;/em&gt; L. commonly known as broccoli, is rich in phenolics mainly flavonoids and possesses excellent antioxidant property, however its anxiolytic potential has not been investigated. Thus in the present study antianxiety activity of extracts of broccoli was evaluated in experimental animals. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Various pharmacognostic parameters of the plant material were studied following standard procedures. Groups of six mice each were taken as different treatment groups. Control group received vehicle (1% Carboxy Methyl Cellulose), positive control received Diazepam (2mg/kg) as standard drug while test groups received petroleum ether and hydroalcoholic extracts (50, 100 and 200 mg/kg body weight, p.o.). The effects were evaluated on Elevated Plus Maze (EPM), hole board and mirror chamber tests. Statistical analysis was performed using ANOVA, followed by Turkey&amp;rsquo;s post-hoc test. &lt;strong&gt;Results:&lt;/strong&gt; Hydroalcoholic extract shows dose dependent increase in the average time spent and frequency of entries in the open arms of the EPM; decreased latency, increased time spent and frequency of entries in the mirror chamber; increased number of head dips in hole board test as compared to control was observed. These effects were comparable to the effect produced by diazepam. Phytochemical screening of the bioactive extract revealed the presence of alkaloids, phenols, flavonoids and tannins. &lt;strong&gt;Conclusion:&lt;/strong&gt; From our study, it can be concluded that hydroalcoholic extract of &lt;em&gt;Brassica oleracea &lt;/em&gt;at the dose of 200 mg/kg possesses marked anxiolytic activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">638</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Divneet Kaur,&lt;sup&gt;1&lt;/sup&gt; Richa Shri,&lt;sup&gt;2&lt;/sup&gt; Anjoo Kamboj&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;I.K.Gujral Punjab Technical University, Jalandhar, INDIA&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences and Drug Research, Patiala, INDIA&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Chandigarh College of Pharmacy, Landran, Mohali, Punjab, INDIA&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ram Niwas Jangir</style></author><author><style face="normal" font="default" size="100%">Gyan Chand Jain</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cassia fistula Linn. pod in Streptozotocin-Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Blood glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Cassia fistula</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycogen</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycosylated Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/pj-9-5/10.5530pj.2017.5.95/index.html</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">599-606</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes mellitus (DM) is a global health problem and the incidence of DM is increasing at alarming rate all over the world. Many Indian medicinal plants have been reported to possess potential antidiabetic activity and could play important role in the management diabetes. &lt;strong&gt;Objective:&lt;/strong&gt; The present study aimed to evaluate antidiabetic activities of 70% ethanolic extract of &lt;em&gt;Cassia fistula&lt;/em&gt; pod in streptozotocin-induced diabetic rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Diabetes was induced in male Wistar rats by single intraperitoneal injection of streptozotocin (60 mg/kg b.wt.). The diabetic rats were administered orally with &lt;em&gt;C. fistula&lt;/em&gt; pod extract at three different doses (100, 250 and 500 mg/kg b.wt./day) for 60 days. The results were compared with standard drug glibenclamide (5 mg/kg b.wt./day) treated rats. &lt;strong&gt;Results:&lt;/strong&gt; The streptozotocin treated diabetic control rats showed a significant increase in the blood glucose and glycosylated hemoglobin (HbA1c) levels with a concomitant decrease in the body weight and glycogen content in the liver as compared to normal control rats. Oral administration of &lt;em&gt;C. fistula&lt;/em&gt; pod extract (100, 250 and 500 mg/kg b.wt./day) or glibenclamide for 60 days showed significant reduction in the blood glucose and HbA1c levels and an elevation in the body weight and hepatic glycogen content as compared to diabetic control rats. Furthermore, treatment with extract (500 mg/kg b.wt.) also showed improvement of oral glucose tolerance test (OGTT) in diabetic rats. These results were comparable to glibenclamide. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of present study showed that&lt;em&gt; C. fistula&lt;/em&gt; pod extract possess significant antihyperglycemic activity and supports the traditional use of &lt;em&gt;C. fistula&lt;/em&gt; pod for the treatment of diabetes mellitus.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">599</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ram Niwas Jangir, Gyan Chand Jain&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sridevi I Puranik</style></author><author><style face="normal" font="default" size="100%">Shridhar C Ghagane</style></author><author><style face="normal" font="default" size="100%">Rajendra B Nerli</style></author><author><style face="normal" font="default" size="100%">Sunil S Jalalpure</style></author><author><style face="normal" font="default" size="100%">Murigendra B. Hiremath</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of in vitro Antioxidant and Anticancer Activity of Simarouba glauca Leaf Extracts on T-24 Bladder Cancer Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant; Anticancer; Bladder Cancer; Phytochemical; Simarouba glauca.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/195</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">906-912</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Screening of preliminary phytochemicals, evaluation of &lt;em&gt;in vitro&lt;/em&gt; antioxidant and &lt;em&gt;in vitro&lt;/em&gt; anticancer activities of &lt;em&gt;Simarouba glauca&lt;/em&gt; leaf extracts on T-24 Bladder cancer cell line. Materials and &lt;strong&gt;Methods:&lt;/strong&gt; Herbal extraction was carried out by Soxhlet method using chloroform, ethylacetate, methanol, ethanol, aqueous and hydroalcohol. Phytochemical investigation was done using biochemical tests. Total phenolic content was estimated by Folin-Ciocalteu reagent (FCR) method. Antioxidant potential of leaf extracts was analyzed by Ferric ion reducing antioxidant power (FRAP) assay, Phosphomolybdenum (PM) assay and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. &lt;em&gt;In vitro&lt;/em&gt; anticancer activity on T-24 bladder cancer cell line was assessed by MTT assay. &lt;strong&gt;Statistical analysis used:&lt;/strong&gt; Statistical analysis of data was performed by analysis of variance (one-way ANOVA) and level of statistical significance between groups was carried out using GraphPad Prism version 5.0 for Windows (GraphPad Software, San Diego, CA, USA). &lt;strong&gt;Results:&lt;/strong&gt; Phytochemical analysis revealed the presence of rich secondary metabolite present in all the solvent extracts. Hydroalcoholic extract showed highest presence of phenolic content (92.38&amp;plusmn;0.29 mg/g) GAE. Ethanol and methanol extract showed highest antioxidant capacity in DPPH, FRAP and PM assay as compared to the other extracts based on the test performed. The results confirmed that ethanol extract significantly (p&amp;lt;0.05) inhibited T-24 cell line with IC50 value (533.55&amp;plusmn;25.02 &amp;mu;g/mL) as compared to standard drug doxorubicin (0.16&amp;mu;M/mL). &lt;strong&gt;Conclusions:&lt;/strong&gt; The results of the present findings strengthen the potential property of &lt;em&gt;Simarouba glauca&lt;/em&gt; as a resource for the discovery of novel antioxidant and anticancer agents.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">906</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sridevi I. Puranik&lt;sup&gt;1,2&lt;/sup&gt;, Shridhar C. Ghagane&lt;sup&gt;3&lt;/sup&gt;, Rajendra B. Nerli&lt;sup&gt;4&lt;/sup&gt;, Sunil S. Jalalpure&lt;sup&gt;5,6&lt;/sup&gt;, Murigendra B. Hiremath&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology and Microbiology, Karnatak University Dharwad-580003, Karnataka, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, K.L.E&amp;rsquo;S R. L. Science Institute (Autonomous), Belagavi-590001, Karnataka, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Urology, KLES Kidney Foundation, KLES Dr. Prabhakar Kore Hospital &amp;amp; Medical Research Centre, Belagavi-590001, Karnataka, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Urology, KLE University&amp;rsquo;s JN Medical College, KLES Kidney Foundation, KLES Dr. Prabhakar Kore Hospital &amp;amp; Medical Research Centre, Belagavi-590010, Karnataka, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;KLE University&amp;rsquo;s Dr. Prabhakar Kore Basic Science Research Centre, Belagavi- 590010, Karnataka, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;KLE University&amp;rsquo;s College of Pharmacy, Nehru Nagar, Belagavi-590010, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arun Kashivishwanath Shettar</style></author><author><style face="normal" font="default" size="100%">Ankala Basappa Vedamurthy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of in-vitro Anthelmintic Activity of Ximenia americana, Hopea ponga and Vitex leucoxylon</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hopea ponga</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro anthelmintic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Pheretima Posthuma model</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitex leucoxylon</style></keyword><keyword><style  face="normal" font="default" size="100%">Ximenia americana</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.62</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">367-371</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Evaluating Anthelmintic activity of&lt;em&gt; Ximenia americana,&lt;/em&gt; &lt;em&gt;Hopea ponga&lt;/em&gt; and &lt;em&gt;Vitex leucoxylon&lt;/em&gt; extracts by using in vitro assay. &lt;strong&gt;Methods:&lt;/strong&gt; The serial exhaustive extraction was carried out with a series of solvents: chloroform, ethyl acetate, methanol, ethanol and water with increasing polarity using Soxhlet apparatus. The concentrated and dried extracts were evaluated for anthelmintic activity by employing standard &lt;em&gt;in vitro&lt;/em&gt; method (&lt;em&gt;Pheretima Posthuma&lt;/em&gt; model). &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;In vitro&lt;/em&gt; anthelmintic study shows that in case of &lt;em&gt;Ximenia americana&lt;/em&gt; chloroform extract showed higher anthelmintic activity where as incase of Hopea ponga and Vitex leucoxylon methanol extract exhibited significant activity when compared to other solvent extracts. &lt;strong&gt;Conclusion:&lt;/strong&gt; Results confirm that methanol extract of &lt;em&gt;Hopea ponga&lt;/em&gt; exhibited highest anthelmintic activity among all tested extracts. This study provides scientific evidence that the leaves of &lt;em&gt;Ximenia americana,&lt;/em&gt; &lt;em&gt;Hopea ponga&lt;/em&gt; and &lt;em&gt;Vitex leucoxylon&lt;/em&gt; have anthelmintic efficacy. However further comprehensive chemical and pharmacological investigation should be carried out to isolate the active compounds and appropriate elucidation of its mechanism of action and it helps in the development of new pharmaceuticals to treat Helminthiasis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">367</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arun Kashivishwanath Shettar and Ankala Basappa Vedamurthy&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;P G Department of Studies in Biotechnology and Microbiology, Karnataka University, Dharwad 580003, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Emmanuel Oladipo AJANI</style></author><author><style face="normal" font="default" size="100%">Saheed SABIU</style></author><author><style face="normal" font="default" size="100%">Kuburat Temitope ODUFUWA</style></author><author><style face="normal" font="default" size="100%">Taiwo Bashir Ibrahim</style></author><author><style face="normal" font="default" size="100%">Bamidele Adewale Salau</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Lens Aldose Reductase Inhibitory and Free Radical Scavenging Potential of Fractions of Lonchocarpus cyanescens: Potential for Cataract Remediation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aldose reductase</style></keyword><keyword><style  face="normal" font="default" size="100%">Cataract</style></keyword><keyword><style  face="normal" font="default" size="100%">Free radical</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical constituents.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">62-69</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Current research effort at discovering effective anticataract agent is focus on evaluating Aldose reductase inhibition (ARI) capacities of medicinal plants and plant extracts. The present study was aimed at investigating the &lt;em&gt;in vitro&lt;/em&gt; ARI activity of fractions of &lt;em&gt;Lonchocarpus cyanescens&lt;/em&gt; leaves on partially purified AR from goat lens. &lt;strong&gt;Methods:&lt;/strong&gt; Phytochemical constituents of the leaves were screened for using aqueous and methanolic extract while &lt;em&gt;in vitro&lt;/em&gt; free radical scavenging and ARI activities of the fractions were evaluated using partially purified aldose reductase. Kinetics of the enzyme in the presence of fractions of the leaves was then compared using Lineweaver-Burk plot. &lt;strong&gt;Results:&lt;/strong&gt; Phenol, flavonoid, tannins and phlobatannins were detected in both extracts. All the fractions inhibited AR significantly but this was strongest with aqueous (IC&lt;sub&gt;50&lt;/sub&gt;, 0.06 &amp;plusmn; 0.02 mM&lt;sup&gt;-1&lt;/sup&gt; and chloroform fractions (IC50, 0.09 &amp;plusmn; 0.01 mM&lt;sup&gt;-1&lt;/sup&gt;). Ethyl acetate, hexane and methanol fraction showed competitive inhibition whereas the aqueous and chloroform fractions showed mixed inhibition with a different V&lt;sub&gt;max&lt;/sub&gt; and K&lt;sub&gt;m &lt;/sub&gt;when compared with DL-glyceraldehyde. All the fractions also showed antioxidant capacities but this was also strongest with aqueous fraction. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study confirms the ARI and antioxidant capacity of &lt;em&gt;Lonchocarpus cyanescens&lt;/em&gt; which may be attributed to its phenolic constituents and whose extraction is solvent dependent. The plant may therefore serve as a base for the development of anticataract agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">62</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Emmanuel Oladipo Ajani&lt;sup&gt;1*&lt;/sup&gt;, Saheed Sabiu&lt;sup&gt;1,2&lt;/sup&gt;, Kuburat Temitope Odufuwa&lt;sup&gt;3&lt;/sup&gt;, Taiwo Bashir Ibrahim&lt;sup&gt;1&lt;/sup&gt; and Bamidele Adewale Salau&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Kwara State University, Malete, Department of Biosciences and Biotechnology, Phytomedicine and Drug Development Laboratory, P. M. B. 1530, Ilorin, Nigeria.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;University of the Free State, Faculty of Natural and Agricultural Science South Africa.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, OlabisiOnabanjoUnivesity, Remo Campus, Ikenne, Nigeria.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Chemical sciences/Natural sciences, Redemer&amp;rsquo;s University, Ede, Osun State.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Camille Rabadeaux</style></author><author><style face="normal" font="default" size="100%">Lou Vallette</style></author><author><style face="normal" font="default" size="100%">Joseph Sirdaarta</style></author><author><style face="normal" font="default" size="100%">Craig Davis</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">African mahogany</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti bacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-cancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-proliferative activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Giardia duodenalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Meliaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Sub-critical fluid extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpenoid.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.82</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">504-518</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Khaya senegalensis&lt;/em&gt; (Desr.) A. Juss. is a common component of the pharmacopeia&amp;rsquo;s of multiple African groupings which inhabit the areas in which it grows. Amongst these groups there is a myriad of medicinal uses in the treatment of a wide variety of bacterial, fungal and protozoal infections, as well as in the treatment of cancers. This study was undertaken to test &lt;em&gt;K. senegalensis&lt;/em&gt; bark extracts for the ability to inhibit microbial and cancer cell growth, and thus to validate traditional African medicinal usage of this plant in treating a variety of diseases. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; &lt;em&gt;K. senegalensis&lt;/em&gt; bark powder was extracted by both solvent maceration and subcritical fluid extraction (SFE). The extracts were tested for the ability to inhibit bacterial and &lt;em&gt;G. duodenalis &lt;/em&gt;growth. Inhibition of Caco-2 and HeLa cancer cells was evaluated using MTS-based colorimetric cell proliferation assays. Toxicity was evaluated using an &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay and GC-MS headspace analysis was used to identify phytochemical components. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;K. senegalensis&lt;/em&gt; bark extracts displayed strong inhibitory activity against bacterial triggers of several autoimmune inflammatory diseases. The growth inhibitory activity of the methanolic and subcritical extracts was particularly noteworthy against &lt;em&gt;P. mirabilis&lt;/em&gt; (MIC values of 185 and 211&amp;mu;g/mL, respectively against the reference strains). These extracts were similarly potent growth inhibitors of &lt;em&gt;K. pneumoniae&lt;/em&gt; and A. &lt;em&gt;baylyi&lt;/em&gt;&amp;nbsp;and were moderate inhibitors (MIC &amp;gt;1000&amp;mu;g/mL) of &lt;em&gt;P. aeruginosa&lt;/em&gt; and &lt;em&gt;S. pyogenes&lt;/em&gt; growth. The methanolic and subcritical &lt;em&gt;K. senegalensis&lt;/em&gt; extracts were also potent inhibitors of &lt;em&gt;G. duodenalis &lt;/em&gt;(187 and 328&amp;mu;g/mL, respectively), as well as Caco-2 (268 and 470&amp;mu;g/mL, respectively) and HeLa carcinomas (155 and 174&amp;mu;g/mL, respectively). GC-MS analysis of the SFE extract revealed &lt;em&gt;relative&lt;/em&gt; abundances of a variety of mono- and sesquiterpenoids. Furthermore, all &lt;em&gt;K. senegalensis&lt;/em&gt; bark extracts were non-toxic in the &lt;em&gt;Artemia franciscana&lt;/em&gt; toxicity assay, indicating their safety for therapeutic use. &lt;strong&gt;Conclusion:&lt;/strong&gt; These studies validate traditional African therapeutic usage of &lt;em&gt;K. senegalensis&lt;/em&gt; in the treatment of microbial infections, autoimmune inflammatory diseases and some cancers.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">504</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Camille Rabadeaux&lt;sup&gt;1&lt;/sup&gt;,&lt;sup&gt;2&lt;/sup&gt;, Lou Vallette&lt;sup&gt;1,2&lt;/sup&gt;, Joseph Sirdaarta&lt;sup&gt;1,3&lt;/sup&gt;, Craig Davis&lt;sup&gt;4,5&lt;/sup&gt;, Ian Edwin Cock&lt;sup&gt;1,3&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Environmental Futures Research Institute, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Biology, Ecole de Biologie Industrielle (EBI), Cergy, FRANCE. &amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Natural Sciences, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Botanical Medicine Research Institute, Brisbane, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Bioextracts P/L, Brisbane, AUSTRALIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Krishnendu Acharya</style></author><author><style face="normal" font="default" size="100%">Kanad Das</style></author><author><style face="normal" font="default" size="100%">Soumitra Paloi</style></author><author><style face="normal" font="default" size="100%">Arun Kumar Dutta</style></author><author><style face="normal" font="default" size="100%">Manoj Emanuel Hembrom</style></author><author><style face="normal" font="default" size="100%">Somanjana Khatua</style></author><author><style face="normal" font="default" size="100%">Arvind Parihar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Exploring a novel edible mushroom Ramaria subalpina: Chemical characterization and Antioxidant activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Ferrous ion chelating</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">India.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">30-34</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; During macrofungal inventorisation from an unexplored subalpine forest of Sikkim Himalayas, a new edible mushroom, &lt;em&gt;Ramaria subalpina&lt;/em&gt; was found and documented in consultation with the forest dwellers. &lt;strong&gt;Objective:&lt;/strong&gt; The aim of the present study was to understand the antioxidative potentiality and bioactive constituents of a novel taxon, &lt;em&gt;Ramaria subalpina&lt;/em&gt;, that is highly prized by the ethnic people of subalpine Sikkim Himalayas, India, for its flavor, texture and gastronomic delicacy since time immemorial. &lt;strong&gt;Methods:&lt;/strong&gt; Chemical composition and antioxidant properties of methanolic extract of dried basidiocarps were assessed using HPLC and several in vitro assay systems. &lt;strong&gt;Results:&lt;/strong&gt; Methanolic extract had phenolics in highest amount, among which pyrrogallol was identified. It also showed potent antioxidant activity. Conclusion: The present study suggests that &lt;em&gt;Ramaria subalpina&lt;/em&gt; has strong medicinal prospects. This novel mushroom can safely be added to the world&amp;rsquo;s edible mushrooms list.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">30</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Krishnendu Acharya&lt;sup&gt;1*&lt;/sup&gt;, Kanad Das&lt;sup&gt;2&lt;/sup&gt;, Soumitra Paloi&lt;sup&gt;1&lt;/sup&gt;, Arun Kumar Dutta&lt;sup&gt;1&lt;/sup&gt;, Manoj Emanuel Hembrom&lt;sup&gt;3&lt;/sup&gt;, Somanjana Khatua&lt;sup&gt;1&lt;/sup&gt;, and Arvind Parihar&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Botany, Molecular and Applied Mycology and Plant Pathology Laboratory, University of Calcutta, 35, Ballygunge Circular Road, Kolkata&amp;ndash;700019, West Bengal, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Cryptogamic Unit, Botanical Survey of India, P.O.&amp;ndash;Botanic Garden, Howrah&amp;ndash;711103, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Central National Herbarium, Botanical Survey of India, Central National Herbarium, P. O.&amp;ndash;Botanic Garden, Howrah &amp;ndash; 711103, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ushakiranamayi Mangamuri</style></author><author><style face="normal" font="default" size="100%">Muvva Vijayalakshmi</style></author><author><style face="normal" font="default" size="100%">Venkat Siva Rama Krishna Ganduri</style></author><author><style face="normal" font="default" size="100%">Satish Babu Rajulapati</style></author><author><style face="normal" font="default" size="100%">Sudhakar Poda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extracellular L-Asparaginase from Streptomyces labedae VSM-6: Isolation, Production and Optimization of Culture Conditions Using RSM</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Central Composite Design</style></keyword><keyword><style  face="normal" font="default" size="100%">Kinetic Modelling</style></keyword><keyword><style  face="normal" font="default" size="100%">L - asparaginase</style></keyword><keyword><style  face="normal" font="default" size="100%">Optimization</style></keyword><keyword><style  face="normal" font="default" size="100%">Response Surface Methodology</style></keyword><keyword><style  face="normal" font="default" size="100%">Statistical Analysis.</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptomyces labedae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/199</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">932-941</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present study was intended to isolate actinomycetes VSM-6 from deep sea sediment samples of Bay of Bengal that is potent to produce L - asparaginase. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The identification of the isolate was executed by polyphasic taxonomy. Optimization was carried out one factor at a time (O-F-A-T) for the production of the L - asparaginase. RSM was pledged to optimize the L - asparaginase production by &lt;em&gt;S.labedae&lt;/em&gt; VSM-6. Central composite design was applied to study the influence of the variables and their interactive effects on the production of L - asparaginase. Unstructured Kinetic modelling for L - asparaginase production was adopted using Leudeking-Piret (LILP) and Logistic Incorporated Modified Leudeking-Piret (LIMLP) models. &lt;strong&gt;Results:&lt;/strong&gt; Optimization using One-Factor-At-A-time registered a turnout of 8.92 IU/ml of L - asparaginase production. But results obtained from the statistical design are in agreement with the experimental results. The model followed the second order polynomial equation and the model adequacy was determined by the P value (&amp;lt;0.0001), Coefficient determination (R2) with a value of 0.9942 and the adjusted R2 = 0.9087 which determines that the model was significant. The experimental values are in compliance with the model anticipated values and catalogued an escalation in yield of L - asparaginase (10.17 IU/ml) by RSM. Unstructured Kinetic modelling for L - asparaginase production adopting Leudeking-Piret (LILP) and Logistic Incorporated Modified Leudeking-Piret (LIMLP) models showed L - asparaginase production of (10.17 IU/ml), closer to model anticipated value (10.23 IU/ml) so unstructured models provided a better approximation for L - asparaginase production by &lt;em&gt;S.labedae &lt;/em&gt;VSM-6. &lt;strong&gt;Conclusion:&lt;/strong&gt; From our study we have reported for the first time the production of L - asparaginase from &lt;em&gt;S.labedae&lt;/em&gt; VSM-6 using central composite design and kinetic modelling.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">932</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ushakiranamayi Mangamuri&lt;sup&gt;1&lt;/sup&gt;, Muvva Vijayalakshmi&lt;sup&gt;*1&lt;/sup&gt;, Venkat Siva Rama Krishna Ganduri&lt;sup&gt;2&lt;/sup&gt;, Satish Babu Rajulapati&lt;sup&gt;3&lt;/sup&gt;, Sudhakar Poda&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Botany and Microbiology Acharya Nagarjuna University Nagarjunanagar Guntur-52510, Andhra Pradesh, INDIA.&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology K L University Vaddeswaram Guntur, Andhra Pradesh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Dept of Biotechnology National Institute of Technology Warangal, Telangana, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yudi Her Oktaviono</style></author><author><style face="normal" font="default" size="100%">Alisia Yuana Putri</style></author><author><style face="normal" font="default" size="100%">Makhyan Jibril Al-Farabi</style></author><author><style face="normal" font="default" size="100%">Yesita Rizky Firmansyah</style></author><author><style face="normal" font="default" size="100%">Ferry Sandra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extracellular-Signal Regulated Kinase Signalling Pathway Mediates the Increased Proliferation of EPCs Treated with Garlic (Allium sativum) Extract, Purple Sweet Potato (Ipomoea batatas) Extract and Vitamin C</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Endothelial Progenitor</style></keyword><keyword><style  face="normal" font="default" size="100%">ERK</style></keyword><keyword><style  face="normal" font="default" size="100%">Proliferation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">442-447</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The endothelial progenitor cell (EPCs) proliferation capability is reduced in the patient with stable coronary artery disease (SCAD). Garlic (&lt;em&gt;Allium sativum&lt;/em&gt;), purple sweet potato (Ipomoea batatas), and vitamin C are proven antioxidant which potentially improve EPCs proliferation ability. &lt;strong&gt;Objective:&lt;/strong&gt; To investigate the effect of garlic (&lt;em&gt;Allium sativum&lt;/em&gt;), purple sweet potato (Ipomoea batatas), and vitamin C in EPCs proliferation from CAD patients and identify the involvement of Extracellular-Signal Regulated Kinase (ERK) Signalling Pathway. &lt;strong&gt;Material and Method:&lt;/strong&gt; Mononuclear cells were isolated from SCAD patients and cultivated with colony-forming unit (CFU)-Hill medium and divided into untreated (control), garlic extract (10 mcg/ml and 100 mcg/ml), purple sweet potato extract (1 mcg/ml and 25 μg/ml), and vitamin C (10 μg/ml and 250 μg/ml). EPCs proliferation was measured using the MTT Assay.&lt;strong&gt; Results: &lt;/strong&gt;This research shows that EPCs proliferation was increased in the treatment with garlic extract at 10 mcg/ml and 100 mcg/ml dose (0.267 ± 0,003 and 0.391 ± 0.008 ; p &amp;lt; 0.05), purple sweet potato extract at 1 mcg/ml and 25 μg/ml dose (0.250 ± 0.005 and 0.3562 ± 0.023 ; p &amp;lt; 0.001), and vitamin C at 10 μg/ml and 250 μg/ml dose (0.259 ± 0.016 and 0.306 ± 0.022 ; p &amp;lt; 0.001). Increased ERK expression was found in the treatment with garlic extract, purple sweet potato extract and vitamin C. &lt;strong&gt;Conclusion: &lt;/strong&gt;Garlic extract, purple sweet potato extract, and vitamin C can increase EPC proliferation through the ERK signaling pathway.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">442</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Yudi Her Oktaviono&lt;sup&gt;1,&lt;/sup&gt;*, Alisia Yuana Putri&lt;sup&gt;1&lt;/sup&gt;, Makhyan Jibril Al-Farabi&lt;sup&gt;1,2&lt;/sup&gt;, Yesita Rizky Firmansyah&lt;sup&gt;3&lt;/sup&gt;, Ferry Sandra&lt;sup&gt;4,5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Prof Moestopo Street 6-8, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of Management, Healthcare Entrepreneurship Division, University College London, Gower St, Bloomsbury, WC1E 6BT London, UK.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Postgraduate School of Biomedicine, Faculty of Medicine, Brawijaya University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Prodia Stem Cell Laboratory, Kramat 7 No. 11 Street, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Dentistry, Universitas Trisakti, Kyai Tapa Street No.260, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sunita Shailajan</style></author><author><style face="normal" font="default" size="100%">Suman Kumaria</style></author><author><style face="normal" font="default" size="100%">Suhas Pednekar</style></author><author><style face="normal" font="default" size="100%">Sasikumar Menon</style></author><author><style face="normal" font="default" size="100%">Hiranjit Choudhury</style></author><author><style face="normal" font="default" size="100%">Archana Matani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Estrogenic Potential of Flemingia vestita Benth Tubers in Ovariectomized Rat Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Estrogenic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Flemingia vestita</style></keyword><keyword><style  face="normal" font="default" size="100%">genistein</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">ovariectomized rats.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">44-49</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study investigates the potential estrogenic activity of the ethanolic extract of &lt;em&gt;Flemingia vestita&lt;/em&gt; Benth tubers using ovariectomized rat model.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The ethanolic extract of &lt;em&gt;F. vestita&lt;/em&gt; tubers has been standardized using validated HPLC method in terms of its genistein content (8.43 &amp;plusmn; 0.05 mg/g of extract). Three to four week old young albino Wistar female rats were ovariectomized and treated for 14 days post ovariectomy with the standardized ethanolic extract at three different dose levels (100, 250, 500 mg/kg body weight) with a positive control of Estradiol valerate (1 mg/kg/day). The parameters evaluated were uterine weight, uterine glycogen, G6PDH, LDH, 17&amp;beta;-estradiol, progesterone, total cholesterol, triglycerides, HDL and histo architecture of uterus. &lt;strong&gt;Results:&lt;/strong&gt; Treatment with the ethanolic extract of &lt;em&gt;F. vestita &lt;/em&gt;tubers showed dose dependent increase in uterine weight, glycogen levels, G6PDH levels, estrogen and progesterone levels when compared with the ovariectomized control. Amongst three dose levels, high dose of plant extract showed significant increase in the uterine weight (p &amp;lt; 0.001), uterine glycogen content (p &amp;lt; 0.001), 17-&amp;beta; estradiol and progesterone levels (p &amp;lt; 0.001), G6PDH and LDH levels (p &amp;lt; 0.001) as well as significant decrease in HDL and triglycerides levels (p &amp;lt; 0.001) compared to ovariectomized control. Histopathological evaluation of uteri sections revealed that the high dose of the plant show increase in the endometrial response as indicated by proliferation of endometrial glands and luminal epithelium of the ovariectomized rats. &lt;strong&gt;Conclusion:&lt;/strong&gt; Thus, these data suggests that ethanolic extract (500 mg/kg body weight) of &lt;em&gt;F. vestita&lt;/em&gt; tubers may exhibit good estrogenic activity in ovariectomized rat model.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Estrogenic activity, &lt;em&gt;Flemingia vestita&lt;/em&gt;, genistein, HPLC, ovariectomized rats.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">44</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;margin-left: 9pt; text-align: justify;&quot;&gt;&lt;strong&gt;Sunita Shailajan&lt;sup&gt;1*&lt;/sup&gt;, Suman Kumaria&lt;sup&gt;2&lt;/sup&gt;, Suhas Pednekar&lt;sup&gt;1&lt;/sup&gt;, Sasikumar Menon&lt;sup&gt;3&lt;/sup&gt;,&lt;/strong&gt;&lt;strong&gt; Hiranjit Choudhury&lt;sup&gt;2&lt;/sup&gt; and Archana Matani&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Herbal Research Lab, Ramnarain Ruia College, Matunga (East), Mumbai - 400019, India.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, North-Eastern Hill University, Umshing Mawkynroh, Shillong - 793022, Meghalaya, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute for Advanced Training and Research in Interdisciplinary Sciences, 194, Scheme No. 6, Road No. 15, Sion Koliwada, Sion (E), Mumbai - 400022, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jagdish Chandra Nagar</style></author><author><style face="normal" font="default" size="100%">Lalit Singh Chauhan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antihyperglycemic and Antihyperlipidemic Activity of Leaf Extracts of Breynia vitis-idaea in Alloxan Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journals</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alloxan</style></keyword><keyword><style  face="normal" font="default" size="100%">Breynia vitis-idaea</style></keyword><keyword><style  face="normal" font="default" size="100%">Glibenclamide</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoglycemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypolipidemic.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">259-263</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim&lt;/strong&gt;: The present study was carried out to evaluate the hypoglycemic and hypolipidemic activity of alcohol and aqueous leaf extracts of &lt;em&gt;Breynia vitis-idaea&lt;/em&gt; (Burm. F.) Fischer in alloxan induced diabetic rats. &lt;strong&gt;Methods&lt;/strong&gt;: Diabetes was induced into albino Wistar rats by intraperitonial administration of alloxan (120 mg/kg). Normal and diabetic rats divided into different groups of six each. Alcohol and aqueous leaf extracts (300 mg/kg and 600 mg/kg) and standard drug (Glibenclamide 500 &amp;mu;g/kg) was administered orally for 21 days. Blood samples were collected from overnight fasted normal and diabetic rats on 0&lt;sup&gt;th&lt;/sup&gt;, 7&lt;sup&gt;th&lt;/sup&gt;, 14&lt;sup&gt;th&lt;/sup&gt; and 21&lt;sup&gt;st&lt;/sup&gt; days of treatment. Hypoglycemic activity was evaluated by measuring serum glucose level and glycosylated haemoglobin level after dosing with aqueous and alcohol extracts. Hypolipidemic activity was evaluated by measuring various biochemical parameters like total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein, high density lipoprotein and phospholipids. &lt;strong&gt;Results&lt;/strong&gt;: Both the extracts significantly (P&amp;lt;0.001, p&amp;lt;0.01) reduced fasting blood glucose of alloxan diabetic rats in a dose-related manner, when compared to control and standard. They also have a significant recovery in the levels of parameters measured in lipid profile, when compared to control and standard group. &lt;strong&gt;Conclusion&lt;/strong&gt;: The present investigation established pharmacological evidence to support the folklore claim that it is used as hypoglycemic and hypolipidemic agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">259</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Jagdish Chandra Nagar&lt;sup&gt;1*&amp;nbsp;&lt;/sup&gt;and&amp;nbsp;Lalit Singh Chauhan&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;B. N. Institute of Pharmaceutical Sciences, Udaipur-313001, Rajasthan, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Mohan Lal Sukhadia University, Udaipur-313001,&amp;nbsp;Rajasthan, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mrinmoy Nag</style></author><author><style face="normal" font="default" size="100%">Pulok k Mukherjee</style></author><author><style face="normal" font="default" size="100%">Rajarshi Biswas</style></author><author><style face="normal" font="default" size="100%">Joydeb Chanda</style></author><author><style face="normal" font="default" size="100%">Amit Kar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antimicrobial Potential of Some Indian Ayurvedic Medicinal Plants</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ananas comosus Merrill</style></keyword><keyword><style  face="normal" font="default" size="100%">Annona squamosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Capsicum annuum cayenne</style></keyword><keyword><style  face="normal" font="default" size="100%">Stereospermum suaveolens Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">Viscum articulatum Burm.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">525-533</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Stereospermum suaveolens&lt;/em&gt; Roxb., &lt;em&gt;Viscum articulatum&lt;/em&gt; Burm., &lt;em&gt;Annona squamosa, Capsicum annuum&lt;/em&gt; cayenne, &lt;em&gt;Ananas comosus&lt;/em&gt; Merrill. are used for the management of microbial infection in Ayurveda. The present study was designed to standardize the extract of &lt;em&gt;S. suaveolens&lt;/em&gt; bark (SSB), &lt;em&gt;V. articulatum&lt;/em&gt; aerial part (VAAP), &lt;em&gt;A. squamosa&lt;/em&gt; leaf (ASL), &lt;em&gt;C. annuum&lt;/em&gt; fruit (CACF), &lt;em&gt;A. comosus&lt;/em&gt; fruit (ACF) and performed antibacterial activity. &lt;strong&gt;Methods: &lt;/strong&gt;The antibacterial activity of the five extracts were evaluated against certain bacteria such as &lt;em&gt;B. subtilis, B. cereus, S. aureus &lt;/em&gt;(gram positive); &lt;em&gt;E. coli, S. typhi,&lt;/em&gt; and &lt;em&gt;P. aureugenosa&lt;/em&gt; (gram negative) by disc diffusion method, time course assay, pH sensitivity assay and minimum inhibitory concentration (MICs) through broth micro-dilution method. &lt;strong&gt;Results: &lt;/strong&gt;The plants extracts VAAP, ASL, and CACF showed potent inhibitory activity against &lt;em&gt;S. aureus&lt;/em&gt; with MIC 728, 742, and 698 &lt;em&gt;&amp;mu;&lt;/em&gt;g ml&lt;sup&gt;-1&lt;/sup&gt;, respectively, while CACF showed inhibitory activity against &lt;em&gt;B. subtilis&lt;/em&gt; with MIC 690 &lt;em&gt;&amp;mu;&lt;/em&gt;g ml&lt;sup&gt;-1&lt;/sup&gt;. The results further demonstrated that the inhibitory activity of CACF against &lt;em&gt;E. coli &lt;/em&gt;with MIC 760 &lt;em&gt;&amp;mu;&lt;/em&gt;g ml&lt;sup&gt;-1&lt;/sup&gt;. &lt;em&gt;P. aeruginosa&lt;/em&gt; was inhibited by ASL and CACF with MIC 1100 and 1120 &lt;em&gt;&amp;mu;&lt;/em&gt;g ml&lt;sup&gt;-1&lt;/sup&gt;, respectively. The ASL showed notable MBC against the tested microorganism. Moreover, all extracts were completely inactivated bacterial strains (except &lt;em&gt;B. cereus, S. typhi&lt;/em&gt;) within 2-10 h of exposure, determined by time course assay. &lt;strong&gt;Conclusion: &lt;/strong&gt;The outcomes of our study elucidate that standardized extracts of &lt;em&gt;A. comosus, A. squamosa, C. annuum, S. suaveolens, &lt;/em&gt;and&lt;em&gt; V. articulatum&lt;/em&gt; may be used as natural antimicrobial agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">525</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mrinmoy Nag, Pulok k Mukherjee *, Rajarshi Biswas, Joydeb Chanda, Amit Kar &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mrinal Sanaye</style></author><author><style face="normal" font="default" size="100%">Nimisha Pagare</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of antioxidant effect and anticancer activity against human glioblastoma (U373MG) cell lines of Murraya Koenigii</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Flow cytometry..</style></keyword><keyword><style  face="normal" font="default" size="100%">Glioblastoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Murraya Koenigii</style></keyword><keyword><style  face="normal" font="default" size="100%">SRB assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">220-225</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The main aim of the study was to screen the ethanolic (EEMK) and methanolic (MEMK) extracts of &lt;em&gt;Murraya koenigii &lt;/em&gt;(MK&lt;em&gt;) &lt;/em&gt;leaves and their alkaloid fractions (EFMK and MFMK) for their &lt;em&gt;in vitro &lt;/em&gt;anti-oxidant and anticancer activity against U373MG cell lines. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;In vitro &lt;/em&gt;antioxidant activity of extracts and fractions was determined by DPPH Radical assay, Reducing power assay, Inhibition of lipid peroxidation, Superoxide radical scavenging assay and Hydroxyl radical scavenging assay. Cytotoxic effect of MK extracts and fractions was evaluated by performing Sulphorhoda&amp;shy;mine B (SRB) assay and Flow cytometry analysis on U373MG cell lines. &lt;strong&gt;Results: &lt;/strong&gt;Extracts and fractions of MK were found to possess significant antioxidant activity. In SRB colorimetric assay, the efficacy of MK against U373MG cell line was observed due to reduced viability of U373MG cells. Dose dependent significant increase in the percentage of dead cells was also observed. MEMK exhibited significant cytotoxicity than EEMK where&amp;shy;as EFMK and MFMK were not found to be significantly cytotoxic against U373MG cell lines. Flow cytometry analysis revealed that the effective extract MEMK induces cell death in human glioblastoma cells through apoptotic mode of action. &lt;strong&gt;Conclusion: &lt;/strong&gt;The observed anticancer activity of &lt;em&gt;Murraya koenigii &lt;/em&gt;may be due to its antioxidant potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">220</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mrinal Sanaye and Nimisha Pagare &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, 23 Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai: 400005, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zahoor Ahmad Rather</style></author><author><style face="normal" font="default" size="100%">Nateshprabhu M</style></author><author><style face="normal" font="default" size="100%">Sushma DS</style></author><author><style face="normal" font="default" size="100%">Rakesh Kb</style></author><author><style face="normal" font="default" size="100%">Sunil Pai</style></author><author><style face="normal" font="default" size="100%">Ullal sheetal D</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Costus speciosus in Experimental Models of Depression in Albino Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidepressant</style></keyword><keyword><style  face="normal" font="default" size="100%">Costus speciosus</style></keyword><keyword><style  face="normal" font="default" size="100%">Forced swim test</style></keyword><keyword><style  face="normal" font="default" size="100%">Tail suspension</style></keyword><keyword><style  face="normal" font="default" size="100%">Test.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">483-486</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Despite theavailability of numerous antidepressant drugs the therapy of depression is far from satisfactory. Two of the many reasons for this are the delay in onset of effect and the adverse effects associated with most of the antidepressants. &lt;em&gt;Costus speciosus&lt;/em&gt; rhizome has shown adaptogenic activity. &lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the antidepressant activity of50% aqueous-ethanol extract of &lt;em&gt;Costus speciosus&lt;/em&gt; (CS) leaves in experimental models of depression.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Male albino mice were randomly assigned to five groups of six each. We studied three doses of the leaf extract (100, 200 and 400 mg/kg) on two models of depression &amp;ndash; forced swim test and tail suspension test. Imipramine was used as the standard control. Both acute and chronic effects were studied. Drugs (test drug, standard control and vehicle) were administeredorally, one hour before the experiment in the acute study and daily for 14 days for the chronic study. &lt;strong&gt;Results:&lt;/strong&gt; Imipramine showed significant antidepressant activity as demonstrated by a reduction in duration of immobility in both acute and chronic studies of forced swim test and tail suspension test. CS showed a dose dependent antidepressant activity. CS_100 demonstrated an antidepressant effect only in the acute forced swim test. CS_200 demonstrated an antidepressant activity in both acute and chronic forced swim test but not in tail suspension test. CS_400 showed maximum antidepressant activity in both acute and chronic studies, which was comparable to that of the standard drug imipramine.&lt;strong&gt; Conclusion:&lt;/strong&gt; CS showed dose dependent antidepressant activity with CS_400 mg/kg showing maximum effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">483</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Zahoor Ahmad Rather&lt;sup&gt;1&lt;/sup&gt;, Nateshprabhu M&lt;sup&gt;2&lt;/sup&gt;, Sushma DS&lt;sup&gt;3&lt;/sup&gt;, Rakesh Kb&lt;sup&gt;1&lt;/sup&gt;, Sunil Pai&lt;sup&gt;1&lt;/sup&gt;, Ullal Sheetal D&lt;sup&gt;1*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal University, Karnataka, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, TamilNadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Khaja Banda nawaz Institute of Medical Sciences, Kalburgi Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sumanta Mondal</style></author><author><style face="normal" font="default" size="100%">Debjit Ghosh</style></author><author><style face="normal" font="default" size="100%">Seru Ganapaty</style></author><author><style face="normal" font="default" size="100%">Motati Sushrutha Reddy</style></author><author><style face="normal" font="default" size="100%">Karipeddi Ramakrishna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Healing Potential of Achyranthes aspera L. (Amaranthaceae) seeds in excision, incision, dead space and burn wound model-An in-vivo Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Achyranthes aspera L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant enzymes</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydroxyproline</style></keyword><keyword><style  face="normal" font="default" size="100%">Povidone iodine</style></keyword><keyword><style  face="normal" font="default" size="100%">Silver sulfadiazine</style></keyword><keyword><style  face="normal" font="default" size="100%">Thermal burn.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">300-306</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present study deals with the &lt;em&gt;in vivo&lt;/em&gt; investigation of healing properties of &lt;em&gt;Achyranthes aspera&lt;/em&gt; L. seeds in excision, incision, dead space and burn wound model. &lt;strong&gt;Methods:&lt;/strong&gt; Preliminary phytochemical tests were performed to find out different phytoconstituents in the test extract. Acute toxicity test were performed to find any abnormalities in mice. Wound healing activities were performed on Wistar rats using excision, incision, dead space and burn wound model. The percentage of wound closure and period of epithelization were recorded for excision and thermal burn wound model, whereas the breaking strength was recorded in incision wound model. In dead space wound model, hydroxyproline content and granulation tissue antioxidant enzymes like SOD and CAT were estimated. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical investigation showed the presence of alkaloids, carbohydrates, tannins, flavonoids, saponins, lipids and triterpenoids. There were no abnormalities observed in the acute toxicity test. The results of wound healing activity revealed that EEAAS treated group showed an enhanced wound contraction and epithelization period in both excision and burn wound models, whereas in incision wound model the wound breaking strength was significantly increased in extract treated group compared to control. The histology of the skin of healed excised wound showed restoration to almost the normal architecture of the skin in extract treated group compared to the control. In dead space wound model, enhanced antioxidant enzymes and connective tissue markers were observed in the extract treated group. &lt;strong&gt;Conclusion:&lt;/strong&gt; Thus the results conclude that EEAAS possesses potent wound healing properties with a reasonable safety profile.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">300</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sumanta Mondal&lt;sup&gt;1&lt;/sup&gt;*, Debjit Ghosh&lt;sup&gt;2&lt;/sup&gt;, Seru Ganapaty&lt;sup&gt;1&lt;/sup&gt;, Motati Sushrutha Reddy&lt;sup&gt;1&lt;/sup&gt;, Karipeddi Ramakrishna&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, Andhra Pradesh, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tabarak Malik</style></author><author><style face="normal" font="default" size="100%">Devendra Kumar Pandey</style></author><author><style face="normal" font="default" size="100%">Priyanka Roy</style></author><author><style face="normal" font="default" size="100%">Annie Okram</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Phytochemicals, Antioxidant, Antibacterial and Antidiabetic Potential of Alpinia galanga and Eryngium foetidum Plants of Manipur (India)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A. galangal</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">E. foetidum.</style></keyword><keyword><style  face="normal" font="default" size="100%">Manipur</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">459-464</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt;&lt;em&gt; Alpinia galanga&lt;/em&gt; and &lt;em&gt;Eryngium foetidum&lt;/em&gt; are two commonly used traditional aromatic plants of Manipur which is traditionally used in Aroma therapy. Rationale of pharmacological potentials of these plants are still unclear, even if few preliminary studies are available in literature for individual plants. &lt;strong&gt;Objective:&lt;/strong&gt; This study was conducted for comparative assessment of antioxidant, antibacterial, and antidiabetic potential of &lt;em&gt;A. galanga &lt;/em&gt;and &lt;em&gt;E. foetidum&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The rhizome of &lt;em&gt;A. galanga &lt;/em&gt;and leaf of &lt;em&gt;E. foetidum&lt;/em&gt; were extracted in methanol, ethanol and water. Phytochemicals of each extracts of &lt;em&gt;Alpinia galanga&lt;/em&gt; and &lt;em&gt;Eryngium foetidum&lt;/em&gt; were analyzed. The antioxidant potential of all the extracts was assessed by measuring total phenolic content, total flavonoid content and free radical scavenging potential was assessed by 1,1-diphenyl-2-picrilhydrazyl (DPPH) assay, antibacterial activity was assessed against various pathogenic and nonpathogenic bacteria &lt;em&gt;in vitro&lt;/em&gt; by Kirby-Bauer agar well diffusion method and antidiabetic activity was assessed by &amp;alpha;-amylase inhibition. &lt;strong&gt;Results:&lt;/strong&gt; Both the plant showed presence of all the tested phytochemicals. It was observed that methanolic extracts of both the plants have higher phenolic content than ethanolic and aqueous extracts, however ethanolic extracts &lt;em&gt;E. foetidum&lt;/em&gt; shows higher flavonoid contents. Both the plant shows similar DPPH scavenging and metal chelating activity. It was also observed that the antidiabetic potential of &lt;em&gt;A. galanga &lt;/em&gt;is greater than &lt;em&gt;E. foetidum&lt;/em&gt;. The methanolic and ethanolic extracts of the plants shows quite similar and good antibacterial potential than the aqueous extracts.&lt;strong&gt; Conclusion:&lt;/strong&gt; The present study suggests that both &lt;em&gt;Alpinia galanga&lt;/em&gt; and &lt;em&gt;Eryngium foetidum&lt;/em&gt; plants of Manipur could be used as herbal remedies for the treatment of diabetes mellitus as well as managing oxidative stress and oxidative stress related disorders.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">459</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Tabarak Malik&lt;sup&gt;1*&lt;/sup&gt;, Devendra Kumar Pandey&lt;sup&gt;2&lt;/sup&gt;, Priyanka Roy&lt;sup&gt;3&lt;/sup&gt;, Annie Okram&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biomedical Sciences, College of Health Sciences, Jimma University, Jimma, ETHIOPIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, School of Biosciences, Lovely Professional University, Phagwara-144402, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Junior Research Fellow, Defence Research and Development Organisation (DRDO), Defence Institute of Bio Energy Research (DIBER), Haldwani, Uttarakhand, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Deepa Chundayil Kalarickal</style></author><author><style face="normal" font="default" size="100%">Sujith Samraj</style></author><author><style face="normal" font="default" size="100%">Darsana Udayan</style></author><author><style face="normal" font="default" size="100%">Priya Manakkulaparambil Narayanan</style></author><author><style face="normal" font="default" size="100%">Sreedevi Ramachandran</style></author><author><style face="normal" font="default" size="100%">Sreeshitha Sreedharan Gouri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of various extracts of Ocimum sanctum and Mallotus phillipensis on Setaria digitata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albendazole</style></keyword><keyword><style  face="normal" font="default" size="100%">Anthelmintic</style></keyword><keyword><style  face="normal" font="default" size="100%">Mallotus phillipensis</style></keyword><keyword><style  face="normal" font="default" size="100%">Ociumum sanctum</style></keyword><keyword><style  face="normal" font="default" size="100%">Setaria digitata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">344-347</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The anthelmintic activity of various extracts of leaves of Ocimum sanctum and Mallotus phillipensis was assessed in vitro against Setaria digitata. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The leaves of Ocimum sanctum and Mallotus phillipensis were collected and were extracted using methanol, dried and stored under refrigeration till further use. The aqueous extract was taken as a decoction. The methanolic extract was further fractionated by taking solvents of increasing polarity viz, hexane, chloroform, n-butanol and water. The extract as well as the fractions were analysed qualitatively for various phytochemical constituents. Fresh nematodes (Setaria digitata) were recovered manually from the peritoneum of infested buffalo, were washed and transferred to the extract containing petriplates (concentrations of 50, 25, 12.5, 6.25, 3.125 and 1.56 mg/ml) immediately and the motility/death of Setaria digitata was noted. &lt;strong&gt;Results:&lt;/strong&gt; The presence of flavonoids and tannins were detected in all the extracts where was phenolics as absent in the hexane fraction. The methanolic extract of Tulsi and Kamla produced death of nematodes in concentrations of 3.125 mg/ml and the extract of tulsi was found to be more potent. Similar results were also observed in the case of hydro alcoholic extract whereas the aqueous extract showed no effect. The chloroform fraction of Ocimum sanctum and n-butanol and chloroform fractions of Mallotus were equally potent in inhibiting the motility and producing death of the worms. The control drug, albendazole produced death in 30 minutes in both the concentrations. &lt;strong&gt;Conclusion:&lt;/strong&gt; It could be concluded that higher doses of the extract are as potent as albendazole.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">344</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Deepa Chundayil Kalarickal, Sujith Samraj*, Darsana Udayan, Priya Manakkulaparambil Narayanan, Sreedevi Ramachandran and Sreeshitha Sreedharan Gouri&lt;/strong&gt; Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Pookode Kerala, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manal Mohamed Elhassan Taha</style></author><author><style face="normal" font="default" size="100%">Siddig Ibrahim Abdelwahab</style></author><author><style face="normal" font="default" size="100%">Rashad Elsanousi</style></author><author><style face="normal" font="default" size="100%">Bassem Y. Sheikh</style></author><author><style face="normal" font="default" size="100%">Mahmood Ameen Abdulla</style></author><author><style face="normal" font="default" size="100%">Saif Eldeen Babiker</style></author><author><style face="normal" font="default" size="100%">Husham Elraih</style></author><author><style face="normal" font="default" size="100%">Eldaw Mohamed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of Sidr Honey on the prevention of ethanol-induced gatroulcerogenesis: role of antioxidant and antiapoptotic mechanism</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">157-164</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Sider (&lt;em&gt;Ziziphus spina-christi&lt;/em&gt; (L.) Desf.) Honey has been used for the treatment of gastrointestinal disorders including peptic ulcer. &lt;strong&gt;Aim of the study:&lt;/strong&gt; The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. &lt;strong&gt;Materials and methods:&lt;/strong&gt; Experimental animals were orally treated with sidr honey (100, 250 and 500 mg/kg, respectively) or omeprazole and subsequently exposed to 95% ethanol (5 mL/Kg, orally) to induce acute gastroulcerogenesis. Effectiveness of sidr honey was evaluated using ulcer index, pH of gastric juice, mucus content, morphological analyses, glutathione assay and malondialdehyde level. The anti-apoptotic role of sidr honey was studied using immunohistochemical staining of gastric tissues using monoclonal antibodies of Bax pathway. Results: Dose-response studies in ethanol-induced ulcer indicate that sidr honey significantly blocks gastric lesions at lower dose (100 mg/kg). Lipid peroxidation and glutathione depletion were significantly inhibited by sidr honey. Sidr honey modulated the immuno-expression of mitochondrial associated protein (Bax). &lt;strong&gt;Conclusion: &lt;/strong&gt;Thus, sider honey plays a considerable role in gastro protection by acting as a potent antioxidant and antiapoptotic agent. Future study is required to explore its potential clinical usage.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">157</style></section></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manal Mohamed Elhassan Taha</style></author><author><style face="normal" font="default" size="100%">Siddig Ibrahim Abdelwahab</style></author><author><style face="normal" font="default" size="100%">Rashad Elsanousi</style></author><author><style face="normal" font="default" size="100%">Bassem Y. Sheikh</style></author><author><style face="normal" font="default" size="100%">Mahmood Ameen Abdulla</style></author><author><style face="normal" font="default" size="100%">Saif Eldeen Babiker</style></author><author><style face="normal" font="default" size="100%">Husham Elraih</style></author><author><style face="normal" font="default" size="100%">Eldaw Mohamed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of Sidr Honey on the prevention of ethanol-induced gatroulcerogenesis: role of antioxidant and antiapoptotic mechanism</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiapoptotic Mechanism</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastro protection</style></keyword><keyword><style  face="normal" font="default" size="100%">monofloral nectar</style></keyword><keyword><style  face="normal" font="default" size="100%">Sidr Honey.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">13th Feb, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">157-164</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Sider &lt;em&gt;(Ziziphus spina-christi&lt;/em&gt; (L.) Desf.) Honey has been used for the treatment of gastrointestinal disorders including peptic ulcer. &lt;strong&gt;Aim of the study:&lt;/strong&gt; The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. &lt;strong&gt;Materials and methods: &lt;/strong&gt;Experimental animals were orally treated with sidr honey (100, 250 and 500 mg/kg, respectively) or omeprazole and subsequently exposed to 95%ethanol (5 mL/Kg, orally) to induce acute gastroulcerogenesis. Effectiveness of sidr honey was evaluated using ulcer index, pH of gastric juice, mucus content, morphological analyses, glutathione assay and malondialdehyde level. The anti-apoptotic role of sidr honey was studied using immunohistochemical staining of gastric tissues using monoclonal antibodies of Bax pathway. &lt;strong&gt;Results: &lt;/strong&gt;Dose-response studies in ethanol-induced ulcer indicate that sidr honey significantly blocks gastric lesions at lower dose (100 mg/kg). Lipid peroxidation and glutathione depletion were significantly inhibited by sidr honey. Sidr honey modulated the immuno-expression of mitochondrial associated protein (Bax).&lt;strong&gt; Conclusion:&lt;/strong&gt; Thus, sider honey plays a considerable role in gastro protection by acting as a potent antioxidant and antiapoptotic agent. Future study is required to explore its potential clinical usage.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Antiapoptotic Mechanism, Antioxidant Agents, Gastro protection, Monofloral Nectar, Sidr Honey.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">157</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Manal Mohamed Elhassan Taha&lt;sup&gt;1*&lt;/sup&gt;, Siddig Ibrahim Abdelwahab&lt;sup&gt;1&lt;/sup&gt;, Rashad Elsanousi&lt;sup&gt;1&lt;/sup&gt;, Bassem Y. Sheikh&lt;sup&gt;2&lt;/sup&gt;, Mahmood Ameen Abdulla&lt;sup&gt;3&lt;/sup&gt;, Saif Eldeen Babiker&lt;sup&gt;1&lt;/sup&gt;, Husham Elraih&lt;sup&gt;1&lt;/sup&gt;, Eldaw Mohamed&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Research Centre, Jazan University, Jazan, Saudi Arabia&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;MABL Scientific Chair, Department of Surgery, College of Medicine, Taibah University, Saudi Arabia&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Malaysia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hassan Lawal Sani</style></author><author><style face="normal" font="default" size="100%">Ibrahim Malami</style></author><author><style face="normal" font="default" size="100%">Sanusi Wara Hassan</style></author><author><style face="normal" font="default" size="100%">Alhassan Muhammad Alhassan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of standardized stem bark extract of Mangifera indica L. in Wister rats with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2</style></keyword><keyword><style  face="normal" font="default" size="100%">4-dinitrophenylhydrazine</style></keyword><keyword><style  face="normal" font="default" size="100%">Anaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemolysis Mangifera indica L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Dec, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">89-96</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The aqueous decoction of the stem back of&lt;em&gt; Mangifera indica&lt;/em&gt; L. has been traditionally used for the treatment of various illnesses among them includes anaemia.&lt;strong&gt; Aims: &lt;/strong&gt;The aim of this study was to investigate the anti-anaemic properties of the standardized stem bark extract of &lt;em&gt;M. indica&lt;/em&gt; in animals with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia. &lt;strong&gt;Methods and Material:&lt;/strong&gt; An&lt;em&gt; in vivo&lt;/em&gt; animal model was used in this experiment. 2,4-dinitrophenylhydrazine was used to induce haemolysis and treatment was done with three different concentrations (25, 50, and 100 mg/kg b.wt) of the plant extract. Astifer&amp;reg; was used as a positive control. Haematological parameters such as PCV, HGb concentration, and TLC were performed to determine the present of phytoconstituents within the crude extract. &lt;strong&gt;Results:&lt;/strong&gt; PCV and HGb concentration was increased significantly (p&amp;lt;0.001) at a dose of 50 and 100 mg/kg b.wt respectively while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 mg/kg b.wt. TLC was decreased significantly (p&amp;lt;0.001) at a dose 100 mg/kg b.wt when while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 and 50 mg/kg b.wt respectively. GC-MS analysis revealed the presence of 15 compounds among viz: 2,2-Dimethoxybutane, N-Acetyl-Alpha-D-glucosamine, 1,2-Benzenediol, Phenol, 2,4-bis(1,1-dimethylethyl)-, Vitamin E, Pentadecanoic acid, 13-methyl-, methyl ester, 2-Ethylacridine, Benzofuran-6-ol-3-one, 2-(4ethoxycarbonyl)benzylidene-, 9-Octadecanoic acid, (E)-, 2,4,6-Cycloheptatrien-1-one, 3,5-bis-trimethylsilyl-, and Benzo[h]quinoline,2,4-dimethyl-. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of our present finding suggest the significant anti-anaemic properties of standardized stem bark extract of &lt;em&gt;Mangefera indica&lt;/em&gt; L. This finding highlights the potentials of the extract&lt;em&gt; M. indica&lt;/em&gt; in the treatment of haemolytic anaemia.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;2,4-dinitrophenylhydrazine, Anaemia, GC-MS analysis, Haemolysis &lt;em&gt;Mangifera indica&lt;/em&gt; L.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">89</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Hassan Lawal Sani&lt;sup&gt;1&lt;/sup&gt;, Ibrahim Malami&lt;sup&gt;*1&lt;/sup&gt;, Sanusi Wara Hassan&lt;sup&gt;2&lt;/sup&gt;, Alhassan Muhammad Alhassan&lt;sup&gt;3&lt;/sup&gt;, Mshelia Emmanuel Halilu&lt;sup&gt;1&lt;/sup&gt;, Aliyu Muhammad&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmcognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Medicinal and Chemistry, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Ahmadu Bello University, Zaria, Nigeria&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hassan Lawal Sani</style></author><author><style face="normal" font="default" size="100%">Ibrahim Malami</style></author><author><style face="normal" font="default" size="100%">Sanusi Wara Hassan</style></author><author><style face="normal" font="default" size="100%">Alhassan Muhammad Alhassan</style></author><author><style face="normal" font="default" size="100%">Mshelia Emmanuel Halilu</style></author><author><style face="normal" font="default" size="100%">Aliyu Muhammad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of standardized stem bark extract of Mangifera indica L. in wistar rats with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2</style></keyword><keyword><style  face="normal" font="default" size="100%">4-dinitrophenylhydrazine</style></keyword><keyword><style  face="normal" font="default" size="100%">Anaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemolysis and Mangifera indica L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">04/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">89-96</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The aqueous decoction of the stem back of Mangifera indica L. has been traditionally used for the treatment of various illnesses among them includes anaemia. Aims: The aim of this study was to investigate the anti-anaemic properties of standardized stem bark extract of M. indica in animals with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia. &lt;strong&gt;Methods and Material:&lt;/strong&gt; An in vivo animal model was used in this experiment. 2,4-dinitrophenylhydrazine was used to induce haemolysis and treatment was done with three different concentrations (25, 50, and 100 mg/kg b.wt) of the plant extract. Astifer&amp;reg; was used as a positive control. Haematological parameters such as PCV, HGb concentration, and TLC were performed and to ascertain the level of haemolysis. GC-MS was used determine the present of phytoconstituents within the crude extract. &lt;strong&gt;Results:&lt;/strong&gt; PCV and HGb concentration increased significantly (p&amp;lt;0.001) at a dose of 50 and 100 mg/kg b.wt respectively while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 mg/kg b.wt. TLC was decreased significantly (p&amp;lt;0.001) at a dose 100 mg/kg b.wt while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 and 50 mg/kg b.wt respectively. GC-MS analysis revealed presence of 15 compounds viz: 2,2-Dimethoxybutane, N-Acetyl-Alpha-D-glucosamine, 1,2-Benzenediol, Phenol, 2,4-bis(1,1-dimethylethyl)-, Vitamin E, Pentadecanoic acid, 13-methyl-, methyl ester, 2-Ethylacridine, Benzofuran-6-ol-3-one, 2-(4ethoxycarbonyl)benzylidene-, 9-Octadecanoic acid, (E)-, 2,4,6-Cycloheptatrien-1-one, 3,5-bis-trimethylsilyl-, and Benzo[h]quinoline,2,4-dimethyl-. &lt;strong&gt;Conclusion: &lt;/strong&gt;The results of our present finding suggest the significant anti-anaemic properties of standardized stem bark extract of Mangefera indica L. This finding highlights the potentials of the extract and M. indica in the treatment of haemolytic anaemia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">89</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Hassan Lawal Sani&lt;sup&gt;1&lt;/sup&gt;, Ibrahim Malami&lt;sup&gt;1*&lt;/sup&gt;, Sanusi Wara Hassan&lt;sup&gt;2&lt;/sup&gt;, Alhassan Muhammad Alhassan&lt;sup&gt;3&lt;/sup&gt;, Mshelia Emmanuel Halilu&lt;sup&gt;1&lt;/sup&gt;, Aliyu Muhammad&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;br /&gt;
&lt;sup&gt;1&lt;/sup&gt;Department of Pharmcognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;br /&gt;
&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;br /&gt;
&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Medicinal and Chemistry, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;br /&gt;
&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Ahmadu Bello University, Zaria, Nigeria&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gaurav Mahesh Doshi</style></author><author><style face="normal" font="default" size="100%">Pratip Kashinath Chaskar</style></author><author><style face="normal" font="default" size="100%">Hemant Devidas Une</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Elucidation of β -sitosterol from Benincasa hispida Seeds, Carissa congesta Roots and Polyalthia longifolia Leaves by High Performance Thin Layer Chromatography</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Benincasa hispida</style></keyword><keyword><style  face="normal" font="default" size="100%">Carissa congesta</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyalthia longifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">β-sitosterol.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">29th Apr, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">221-227</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Fruits of &lt;em&gt;Benincasa hispida&lt;/em&gt; (BH) is regarded as Valliphala due to its vast plethora of medicinal properties, &lt;em&gt;Carissa congesta&lt;/em&gt; (CC) is an imperative local plant particularly in rural communities and &lt;em&gt;Polyalthia longifolia &lt;/em&gt;(PL) is an ornamentally significant traditionally relevance plant in India system. &amp;beta;-sitosterol, an active constituent identified from enormous plants has been reported to possess excellent amount of pharmacotherapeutic potential by number of researchers. &lt;strong&gt;Objective:&lt;/strong&gt; In the recent studies, the research team focuses on determining the percentage of the &amp;beta;-sitosterol present in the BH seeds, CC roots petroleum ether extracts as well as PL leaves ethanolic extract by chromatographic technique in harmony with High Performance Thin Layer Chromatography. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Respective parts of BH, CC and PL plants were shade-dried and extracted by appropriate extraction methods followed by identification of &amp;beta;-sitosterol from the extracts by High Performance Thin Layer Chromatography after preliminary phytochemical screening extracts for the constituents. &lt;strong&gt;Results: &lt;/strong&gt;The amount of &amp;beta;-sitosterol present in the BH seeds, CC roots and PL leaves extracts was found to be 23.00, 5.94 and 1.81 % w/w respectively. Research studies elucidated a peak that coincided with standard peak of &amp;beta;-sitosterol suggesting the presence of constituent in the extracts. &lt;strong&gt;Conclusion:&lt;/strong&gt; Thus, extracts contains important constituent of &amp;beta;-sitosterol in BH, CC and PL.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Benincasa hispida&lt;/em&gt;, &lt;em&gt;Carissa congesta&lt;/em&gt;, HPTLC, &lt;em&gt;Polyalthia longifolia&lt;/em&gt;, &amp;beta;-sitosterol.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">221</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Gaurav Mahesh Doshi, &lt;sup&gt;1, 2*&lt;/sup&gt; Pratip Kashinath Chaskar&lt;sup&gt;1&lt;/sup&gt;, Hemant Devidas Une &lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Pharmaceutical Chemistry, Vivekanand Education Society&amp;rsquo;s College of Pharmacy, Mumbai, India.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Y. B. Chavan College of Pharmacy, Rouzabagh, Aurangabad, Maharashtra, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gaurav Mahesh Doshi</style></author><author><style face="normal" font="default" size="100%">Pratip Kashinath Chaskar</style></author><author><style face="normal" font="default" size="100%">Hemant Devidas Une</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Elucidation of β-sitosterol from Benincasa hispida Seeds, Carissa congesta Roots and Polyalthia longifolia Leaves by High Performance Thin Layer Chromatography</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Benincasa hispida</style></keyword><keyword><style  face="normal" font="default" size="100%">Carissa congesta</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyalthia longifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">β-sitosterol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul-Aug 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">221-227</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Fruits of Benincasa hispida (BH) is regarded as Valliphala due to its vast plethora of medicinal properties, Carissa congesta (CC) is an imperative local plant particularly in rural communities and Polyalthia longifolia (PL) is an ornamentally significant traditionally relevance plant in India system. &amp;beta;-sitosterol, an active constituent identified from enormous plants has been reported to possess excellent amount of pharmacotherapeutic potential by number of researchers.&lt;strong&gt; Objective:&lt;/strong&gt; In the recent studies, the research team focuses on determining the percentage of the &amp;beta;-sitosterol present in the BH seeds, CC roots petroleum ether extracts as well as PL leaves ethanolic extract by chromatographic technique in harmony with High Performance Thin Layer Chromatography.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Respective parts of BH, CC and PL plants were shade-dried and extracted by appropriate extraction methods followed by identification of &amp;beta;-sitosterol from the extracts by High Performance Thin Layer Chromatography after preliminary phytochemical screening extracts for the constituents. &lt;strong&gt;Results: &lt;/strong&gt;The amount of &amp;beta;-sitosterol present in the BH seeds, CC roots and PL leaves extracts was found to be 23.00, 5.94 and 1.81 % w/w respectively. Research studies elucidated a peak that coincided with standard peak of &amp;beta;-sitosterol suggesting the presence of constituent in the extracts. &lt;strong&gt;Conclusion: &lt;/strong&gt;Thus, extracts contains important constituent of &amp;beta;-sitosterol in BH, CC and PL.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">221</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Gaurav Mahesh Doshi&lt;sup&gt;1,2*&lt;/sup&gt;, Pratip Kashinath Chaskar&lt;sup&gt;1 &lt;/sup&gt;and Hemant Devidas Une&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Pharmaceutical Chemistry, Vivekanand Education Society&amp;rsquo;s College of Pharmacy, Mumbai, India 2Department of Pharmaceutical Sciences, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India 3Department of Pharmacology, Y. B. Chavan College of Pharmacy, Rouzabagh, Aurangabad, Maharashtra, India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan</style></author><author><style face="normal" font="default" size="100%">Gunasekar Ramya</style></author><author><style face="normal" font="default" size="100%">Madhusudhanan Gogulramnath</style></author><author><style face="normal" font="default" size="100%">Rajarajeswaran Jayakumar</style></author><author><style face="normal" font="default" size="100%">M.S. Kanthimathi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of cytotoxic, DNA protecting and LPS induced MMP-9 down regulation activities of Plectranthus amboinicus (Lour) Spreng. essential oil.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antigenotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">RT- PCR</style></keyword><keyword><style  face="normal" font="default" size="100%">Zymogram</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">32-36</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour) Spreng is a known medicinal plant used in Siddha and Ayurveda medicines in India. It has enormous medicinal potential to treat various diseases. &lt;strong&gt;Methods:&lt;/strong&gt; The present study focused on the use of essential oil obtained from the leaves of &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; to test cytotoxicity against breast (MCF-7) and colorectal (HT-29) cancer cell lines, to protect DNA from H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; induced genotoxicity through comet assay and to treat inflammation in lipopolysaccharide (LPS) induced over expression of matrix metalloproteinase-9 (MMP-9) in human peripheral blood mononuclear cells (PBMCs) by gelatin zymogram and inhibition at transcriptional level confirmed using RT-PCR (reverse transcriptase polymerase chain reaction). &lt;strong&gt;Results:&lt;/strong&gt; Cytotoxicity of essential oil against MCF-7 and HT-29 cancer cell lines revealed the IC50 values of 53 &amp;plusmn; 0.01 and 87 &amp;plusmn; 0.01&amp;mu;g/mL respectively. At 200 &amp;mu;g/mL essential oil protected against 75% of DNA damage in 3T3-L1 fibroblast cells. Essential oil showed significant reduction in production of MMP-9 in a concentration dependent manner. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall, the results showed that essential oil of &lt;em&gt;P. amboinicus&lt;/em&gt; is a potent bioactive substance and it could be used in herbal medicine preparations.&lt;br /&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt; Essential oil , Cytotoxicity , Antigenotoxicity, Zymogram, RT- PCR.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan, Gunasekar Ramya, Madhusudhanan Gogulramnath, Rajarajeswaran Jayakumar, M.S. Kanthimathi</style></custom1><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramaraj Thirugnanasampandan&lt;sup&gt;a,*&lt;/sup&gt;, Gunasekar Ramya&lt;sup&gt;a&lt;/sup&gt;, Madhusudhanan Gogulramnath&lt;sup&gt;a&lt;/sup&gt;, Rajarajeswaran Jayakumar&lt;sup&gt;b&lt;/sup&gt;, M.S. Kanthimathi&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;b&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Laboratory of Plant Tissue Culture and Molecular Bioprospection, PG and Research Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan</style></author><author><style face="normal" font="default" size="100%">Gunasekar Ramya</style></author><author><style face="normal" font="default" size="100%">Madhusudhanan Gogulramnath</style></author><author><style face="normal" font="default" size="100%">Rajarajeswaran Jayakumar</style></author><author><style face="normal" font="default" size="100%">M.S. Kanthimathi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of cytotoxic, DNA protecting and LPS induced MMP-9 down regulation activities of Plectranthus amboinicus (Lour) Spreng. essential oil</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antigenotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">RT- PCR.</style></keyword><keyword><style  face="normal" font="default" size="100%">Zymogram</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">32-36</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour) Spreng is a known medicinal plant used in Siddha and Ayurveda medicines in India. It has enormous medicinal potential to treat various diseases. &lt;strong&gt;Methods:&lt;/strong&gt; The present study focused on the use of essential oil obtained from the leaves of Plectranthusamboinicusto test cytotoxicity against breast (MCF-7) and colorectal (HT-29) cancer cell lines, to protect DNA from H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; induced genotoxicity through comet assay and to treat inflammation in lipopolysaccharide (LPS) induced over expression of matrix metalloproteinase-9 (MMP-9) in human peripheral blood mononuclear cells (PBMCs) by gelatin zymogram and inhibition at transcriptional level confirmed using RT-PCR (reverse transcriptase polymerase chain reaction). &lt;strong&gt;Results:&lt;/strong&gt; Cytotoxicity of essential oil against MCF-7 and HT-29 cancer cell lines revealed the IC&lt;sub&gt;50&lt;/sub&gt; values of 53 &amp;plusmn; 0.01 and 87 &amp;plusmn; 0.01 &amp;mu;g/mL respectively. At 200 &amp;mu;g/mL essential oil protected against 75% of DNA damage in 3T3-L1 fibroblast cells. Essential oil showed significant reduction in production of MMP-9 in a concentration dependent manner. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall, the results showed that essential oil of &lt;em&gt;P. amboinicus&lt;/em&gt; is a potent bioactive substance and it could be used in herbal medicine preparations.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramaraj Thirugnanasampandan&lt;sup&gt;a,*&lt;/sup&gt;, Gunasekar Ramya&lt;sup&gt;a&lt;/sup&gt;, Madhusudhanan Gogulramnath&lt;sup&gt;a&lt;/sup&gt;, Rajarajeswaran Jayakumar&lt;sup&gt;b&lt;/sup&gt;, M.S. Kanthimathi&lt;sup&gt;b&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Laboratory of Plant Tissue Culture and Molecular Bioprospection, PG and Research Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramya Bashyam</style></author><author><style face="normal" font="default" size="100%">Malarvili Thekkumalai</style></author><author><style face="normal" font="default" size="100%">Velavan Sivanandham</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Phytoconstituents of Bryonopsis laciniosa fruit by UV-Visible Spectroscopy and FTIR analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bryonia laciniosa</style></keyword><keyword><style  face="normal" font="default" size="100%">FTIR</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytonutrients</style></keyword><keyword><style  face="normal" font="default" size="100%">UV-Vis.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09th Mar, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">165-170</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To Investigate the phytochemicals present in &lt;em&gt;Bryonopsis laciniosa&lt;/em&gt; fruit. &lt;strong&gt;Methodology:&lt;/strong&gt; Qualitative, Quantitative screening, Compound Identification by UV-Visible method and identification of functional group of the active chemical components were followed by standard procedures.&lt;strong&gt; Result:&lt;/strong&gt; The results showed the presence of phytonutrients like reducing sugar, terpenoids, triterpenoids, aminoacids, anthroquinone, polyphenols, glycosides, anthocyanins, tannins, coumarins, emodins, saponins, total alkaloids, total flavonoids, lignin and serpentine. These substances may be responsible for the health related properties of the plant which are based on antioxidant,anticancer, antipyretic, antiaphoretic, antidiabetic, anti-inflammation, antiheamatisum, antimicrobial and antiviral activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study supports the popular use of&lt;em&gt; Bryonopsis laciniosa&lt;/em&gt; fruit in preparation of various pharmaceutical formulations for human welfare.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt; Bryonia laciniosa,&lt;/em&gt; FTIR, Phytochemical screening, Phytonutrients, UV-Vis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">165</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramya Bashyam&lt;sup&gt;1&lt;/sup&gt;, Malarvili Thekkumalai&lt;sup&gt;2&lt;/sup&gt; and Velavan Sivanandham&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, P.G. and Research Department of Biochemistry, Rajah Serfoji Govt. College [Autonomous], Thanjavur-613 005, Tamil Nadu, South India.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;P.G. and Research Department of Biochemistry, Rajah Serfoji Govt. College [Autonomous], Thanjavur-613 005, Tamil Nadu, South India.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Madudupandiyar College, Thanjavur, Tamil Nadu, South India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramya Bashyam</style></author><author><style face="normal" font="default" size="100%">Malarvili Thekkumalai</style></author><author><style face="normal" font="default" size="100%">Velavan Sivanandham</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Phytoconstituents of Bryonopsis laciniosa fruit by UV-Visible Spectroscopy and FTIR analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bryonia laciniosa</style></keyword><keyword><style  face="normal" font="default" size="100%">FTIR</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytonutrients</style></keyword><keyword><style  face="normal" font="default" size="100%">UV-Vis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">165-170</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To Investigate the phytochemicals present in &lt;em&gt;Bryonopsis laciniosa&lt;/em&gt; fruit. &lt;strong&gt;Methodology: &lt;/strong&gt;Qualitative, Quantitative screening, Compound Identification by UV-Visible method and identification of functional group of the active chemical components were followed by standard procedures. &lt;strong&gt;Result: &lt;/strong&gt;The results showed the presence of phytonutrients like reducing sugar, terpenoids, triterpenoids, aminoacids, anthroquinone, polyphenols, glycosides, anthocyanins, tannins, coumarins, emodins, saponins, total alkaloids, total flavonoids, lignin and serpentine. These substances may be responsible for the health related properties of the plant which are based on antioxidant, anticancer, antipyretic, antiaphoretic, antidiabetic, anti-inflammation, antiheamatisum, antimicrobial and antiviral activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study supports the popular use of &lt;em&gt;Bryonopsis laciniosa&lt;/em&gt; fruit in preparation of various pharmaceutical formulations for human welfare.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">165</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ramya Bashyam&lt;sup&gt;1&lt;/sup&gt;, Malarvili Thekkumalai&lt;sup&gt;2&lt;/sup&gt; and Velavan Sivanandham&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, P.G. and Research Department of Biochemistry, Rajah Serfoji Govt. College [Autonomous], Thanjavur-613 005, Tamil Nadu, South India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;P.G. and Research Department of Biochemistry, Rajah Serfoji Govt. College [Autonomous], Thanjavur-613 005, Tamil Nadu, South India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Madudupandiyar College, Thanjavur, Tamil Nadu, South India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dr. Sunanda Panda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Digoxigenin-3-O-rutin isolated from Trigonella foenum graecum on T4-induced hyperthyroidism and serum lipid concentrations</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">5”DI</style></keyword><keyword><style  face="normal" font="default" size="100%">Digoxigenin-3-O-rutin</style></keyword><keyword><style  face="normal" font="default" size="100%">hyperthyroidism</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin</style></keyword><keyword><style  face="normal" font="default" size="100%">Serum lipids</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">18th Feb,2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">103-109</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;In this study, effect of digoxigenin-3-O-rutin isolated from the seeds of &lt;em&gt;Trigonella foenum graecum&lt;/em&gt; on thyroid hormones and serum lipid concentrations was evaluated in L-thyroxine (L-T&lt;sub&gt;4&lt;/sub&gt;)-induced hyperthyroidism in rats. Digoxigenin-3-O-rutin was administered (10mg/kg) to L-thyroxine (L-T&lt;sub&gt;4&lt;/sub&gt;)-induced hyperthyroidic rats and alterations in the concentrations of serum thyroid hormones, insulin, glucose, hepatic 5&amp;prime;-monodeiodinase (5&amp;prime;DI) and glucose-6-phosphatase (G-6-Pase) activity were analyzed. Antioxidant status was estimated by determining the levels of antioxidative enzymes and lipidperoxidation. L-T&lt;sub&gt;4&lt;/sub&gt; (500&amp;mu;g/kg, s.c./d) administration increased the serum levels of thyroxine (T4), triidothyronine (T3), glucose, insulin, different lipids, activity of hepatic 5&amp;prime;-DI and G-6-Pase. High lipidperoxidation level was observed both in liver and cardiac tissues with a depletion in cellular antioxidants. On the contrary, test drug (10mg/kg) treatment improved the alterations with respect to hormonal levels, lipid concentrations and lipid peroxidation towards normalcy and enhanced the antioxidant activities. Rats treated with PTU generally gave lower results compared to groups treated with the test drug. The antithyroidic role of the test compound is mediated possibly through the inhibition in 5&amp;prime;DI activity. Improvement in lipid profile by the test drug might have protective effect on cardiovascular health in vivo.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Digoxigenin-3-O-rutin, hyperthyroidism, 5”DI, serum lipids, insulin.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">103</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Dr. Sunanda Panda&lt;sup&gt;*&lt;/sup&gt;, M.Sc, Ph.D&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Devi Ahilya University, Indore, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Natesh Prabhu</style></author><author><style face="normal" font="default" size="100%">Sanjay Hadigal</style></author><author><style face="normal" font="default" size="100%">Ullal sheetal D</style></author><author><style face="normal" font="default" size="100%">Sushma DS</style></author><author><style face="normal" font="default" size="100%">Ashok Shenoy K</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Tribulus Terrestris on Learning And Memory in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hebb William Maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Learning</style></keyword><keyword><style  face="normal" font="default" size="100%">Memory</style></keyword><keyword><style  face="normal" font="default" size="100%">T Maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Tribulus terrestris</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">68-71</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;The present study was designed to evaluate the effect of aqueous extract of fruits of &lt;em&gt;Tribulus terrestri&lt;/em&gt;s on learning and memory in rodents. &lt;strong&gt;Materials and methods:&lt;/strong&gt; Thirty wistar rats were divided in 5 groups of 6 rats each. Baseline values for the time taken to reach reward chamber (TRC) in the Hebb William Maze and transfer latency (TL) in the T-maze were recorded on Day 1. Mean of 5 sessions was calculated for each rat. Group I was normal control, group II piracetam standard, group III, IV and V received &lt;em&gt;Tribulus terrestris&lt;/em&gt; orally at 100mg/kg, 200mg/kg and 400mg/kg respectively for 14 days. At the end of 14 days, each rat was tested for TRC and TL and compared with the control group. &lt;strong&gt;Results:&lt;/strong&gt; Group IV showed a significant decrease in TRC when compared to group I in Hebb William Maze (p&amp;lt;0.0001). Group IV also showed a significant decrease in TL when compared to group I in T-maze (p&amp;lt;0.0001). Group III showed a significant decrease in TL when compared to group I in the T-maze (p=0.035), however there was no decrease in TRC in this group.&lt;strong&gt; Conclusion: &lt;/strong&gt;The aqueous extract of fruits of &lt;em&gt;Tribulus terrestris&lt;/em&gt; showed a dose dependent beneficial effect in learning and memory models in rats, with 200mg/kg being most beneficial.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Hebb William Maze, Learning, Memory, T Maze, &lt;em&gt;Tribulus terrestris&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Natesh Prabhu, Sanjay Hadigal, Ullal Sheetal D&lt;sup&gt;*&lt;/sup&gt;, Sushma DS and Ashok Shenoy K&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, Kasturba Medical College, Light House Hill Road, Mangalore-575001, Manipal University, Manipal, Karnataka, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mehmet Y Gunal</style></author><author><style face="normal" font="default" size="100%">Aylin O Heper,</style></author><author><style face="normal" font="default" size="100%">Nezahat Zaloglu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effects of Topical Carvacrol Application on Wound Healing Process in Male Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">carvacrol; wound healing; TNF-α; IL-1β; TGF-β1; aromatic herbs.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">8th April 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">10-13</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Carvacrol containing products such as Origanum onites have been used as phytotherapeutic agents in the treatment of serious skin injury. It has been suggested that carvacrol is the active component of these herbs because of its anti-microbial property. With the anti-microbial activity and as an ingredient of these herbs, carvacrol is a promising molecule for the treatment of skin injury. In the present study, we have evaluated the efficacy of carvacrol on healing progress after excisional skin injury. Here, Wistar-Albino rats were divided into two groups and treated with carvacrol and vehicle. Carvacrol was administrated topically at a concentration of %12.5 for the 5 consecutive days after excisional skin injury. Tissue samples were harvested on days 3&lt;sup&gt;rd&lt;/sup&gt;, 8&lt;sup&gt;th&lt;/sup&gt; and 12&lt;sup&gt;th&lt;/sup&gt; after injury. Significant beneficial effect of carvacrol was observed at the end of the experiment. In the acute phase of the injury, carvacrol treatment increased tissue granulation and decreased wound depth moderately. These effect of carvacrol was associated with increased TNF-&amp;alpha;. However, at the second half of the experiment the elevated level of TGF-B&lt;sub&gt;1&lt;/sub&gt; was observed as compared with control animals. The level of IL-1&lt;sub&gt;&amp;beta;&lt;/sub&gt; was increased in carvacrol treated animals only on day 8. Here, we provide evidence that carvacrol improves wound healing by regulating pro- inflammatory molecules TNF-&amp;alpha;, IL-1&lt;sub&gt;&amp;beta;&lt;/sub&gt; and TGF-&amp;beta;&lt;sub&gt;1&lt;/sub&gt;.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; carvacrol, wound healing, TNF-&amp;alpha;, IL-1&lt;sub&gt;&amp;beta;&lt;/sub&gt;, TGF-&amp;beta;1, aromatic herbs.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mehmet Y. Gunal&lt;sup&gt;1&lt;/sup&gt;, Aylin O. Heper&lt;sup&gt;2&lt;/sup&gt; and Nezahat Zaloglu&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;3&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Istanbul Medipol University 34810 Istanbul; Turkey&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pathology, Faculty of Medicine, Ankara University 06100 Ankara; Turkey&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Ankara University 06100 Ankara; Turkey.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gautam P. Vadnere</style></author><author><style face="normal" font="default" size="100%">Aslam R. Pathan</style></author><author><style face="normal" font="default" size="100%">Abhay K. Singhai</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Estrogenic Activity of Bauhinia racemosa extract in Female albino rats: An Investigational Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bauhinia racemosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Estrogenic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethinyl estradiol</style></keyword><keyword><style  face="normal" font="default" size="100%">ovariectomy.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">3rd Sept, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">5-9</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the effect of petroleum ether, ethanol and water extract of &lt;em&gt;Bauhinia racemosa&lt;/em&gt; in female albino rats. &lt;strong&gt;Methods:&lt;/strong&gt; Plant extracts were tested for their estrogenic activity by using ovariectomised method at two dose level: 200 mg/kg and 400mg/kg respectively. Further, Plant extracts and Standard drug Ethinyl estradiol (1&amp;micro;g/kg) combination were tested for synergistic estrogenic activity.&lt;strong&gt; Results:&lt;/strong&gt;&lt;em&gt;In-vivo&lt;/em&gt; investigation revealed that ethanol extract at dose of 200 mg/kg and 400 mg/kg shows significance increase 325.23&amp;plusmn;5.23, 328.84&amp;plusmn;4.56 and 3.252&amp;plusmn;0.47, 3.288&amp;plusmn;0.27 in uterine wet weight and uterine weight ratio respectively in female albino rat as compared to control and petroleum ether and water extracts. Simultaneous administration of standard drug Ethinyl estradiol (1&amp;micro;g/kg) with ethanol extract at dose of 200 mg/kg and 400 mg/ kg potentiates (327.36 &amp;plusmn; 5.78, 330.95 &amp;plusmn; 6.21 and 3.273 &amp;plusmn; 0.64, 3.309 &amp;plusmn; 0.49 uterine wet weight and uterine weight ratio respectively in female albino rat) the estrogenic activity as compared to individual administration of ethanol extract as a synergistic effect. &lt;strong&gt;Conclusion:&lt;/strong&gt; It was observed that ethanol extract of &lt;em&gt;Bauhinia racemosa&lt;/em&gt; produced significance estrogenic activity.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Bauhinia racemosa&lt;/em&gt;, estrogenic activity, Ethinyl estradiol, ovariectomy.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">5</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Gautam P. Vadnere&lt;sup&gt;1*&lt;/sup&gt;, Aslam R. Pathan&lt;sup&gt;1&lt;/sup&gt;, Abhay K. Singhai&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Sciences, SMT SS Patil College of Pharmacy, North Maharashtra University, Chopda, Jalgaon, Maharashtra, India,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">D R Kar</style></author><author><style face="normal" font="default" size="100%">G Ghosh</style></author><author><style face="normal" font="default" size="100%">P K Sahu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Estrogenic Effect of Methanolic Extract of Avicennia alba Blume. Aerial Parts in Female Wistar Albino Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Avicennia alba</style></keyword><keyword><style  face="normal" font="default" size="100%">contraceptive</style></keyword><keyword><style  face="normal" font="default" size="100%">Estrogenic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Uterus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">53-58</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To investigate the estrogenic effect of &lt;em&gt;Avicennia alba&lt;/em&gt; (Blume) aerial parts as identified in the folklore recipes as a contraceptive&lt;strong&gt; Methodology: &lt;/strong&gt;The estrogenic activity study of the methanolic extract was carried out by studying the histopathology of the uterus. The uterine weight and vaginal cornification were also observed. The diameter of uterus, thickness of endometrium and height of the endometrial epithelium were measured using a calibrated ocular micrometer. The estimation of total protein and cholesterol was carried out using a standard method described by Lowely et al. &lt;strong&gt;Results:&lt;/strong&gt; The presence of alkaloids, anthraquinone glycosides, flavonoids, steroids, polyphenolics were detected in the aerial parts of Avicennia alba. The methanolic extract of &lt;em&gt;Avicennia alba&lt;/em&gt; at 400 mg/kg body weight showed a significant (&lt;em&gt;p&lt;/em&gt;&amp;lt; 0.05) increase in uterine weight, diameter of uterus, thickness of endometrium and height of the endometrial epithelium compared to the control. There was increase in vaginal cornification status. The histological examination of the uterus also showed estrogenic influence. A significant increase (&lt;em&gt;p&lt;/em&gt;&amp;lt; 0.05) in total protein and cholesterol content in the uterus of standard and test drug treated rats was also observed.&lt;strong&gt; Conclusion:&lt;/strong&gt; The methanolic extract of &lt;em&gt;Avicennia alba&lt;/em&gt; at 400 mg/kg body weight showed significant estrogenic activity and the results are in consistent with the folkloric claim reports related to oral contraceptive effect of &lt;em&gt;Avicennia alba&lt;/em&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Avicennia alba&lt;/em&gt;, contraceptive, estrogenic activity, uterus.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;D R Kar&lt;sup&gt;1*&lt;/sup&gt;, G Ghosh&lt;sup&gt;1&lt;/sup&gt; and P K Sahu&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1*&lt;/sup&gt;School of Pharmaceutical Sciences, Siksha &amp;lsquo;O&amp;rsquo; Anusandhan University, Bhubaneswar, Odisha-751030, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A. Babalola Kadiri,</style></author><author><style face="normal" font="default" size="100%">O. Mawoussi Agboola,</style></author><author><style face="normal" font="default" size="100%">F. Olatunde. Fashina.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical survey and phyto-anatomical studies of some common plants used for the treatment of epilepsy in some rural areas of South west Nigeria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Epilepsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant anatomy</style></keyword><keyword><style  face="normal" font="default" size="100%">south-west Nigeria</style></keyword><keyword><style  face="normal" font="default" size="100%">tropical forestv</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">18th Feb,2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">96-102</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; To survey some areas in the southwest Nigeria where epilepsy is treated with plant extracts and determine the commonest plant species that are used, for pharmacognostic analysis. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Open-ended and semi-structured interviews were conducted for information from traditional medicine practitioners. Plant names given were authenticated in the herbarium and phytochemical and anatomical analyses were conducted on the plant parts that are used for treatment using standard approaches.&lt;strong&gt; Results:&lt;/strong&gt; Fifty practitioners were interviewed and they gave 17 different plants; out of these, the 5 commonest ones were investigated. The plants are either used individually or in combination with other plant(s). Services may be rendered freely or by collecting a token which is supernaturally believed to have negative consequences. The practitioners engaged in out-patient and in-patient services and patients are usually totally cured. There are also some inexplicable practices such as oracle visitation, incantations etc. A total of 30 patients have been cured in the last decade by each practitioner. Saponin, steroids, tannins, flavonoids, phlobatannins and alkaloids were isolated using three different media (methanol, petroleum ether and water) and diagnostic anatomical characters of the leaf epidermis, fruit wall, bark and root of the plants are presented in a single account for the first time in the country. The plants studied were &lt;em&gt;Newbouldia laevis&lt;/em&gt;, &lt;em&gt;Securidaca longipedunculata&lt;/em&gt;, &lt;em&gt;Tetrapleura tetraptera&lt;/em&gt;, &lt;em&gt;Nicotiana tabacum&lt;/em&gt; and &lt;em&gt;Senna occidentalis&lt;/em&gt;.&lt;strong&gt; Conclusion:&lt;/strong&gt; The phytochemicals found are suggestive of the underlying medicinal potency of the plants and future work will help to establish the most active principles which will lead to development of drugs for treating the disease. The diagnostic anatomical characters can be employed in resolving doubts especially when the plant materials are in fragments. The least mentioned plant species can be saved from harvesting to conserve the rich flora diversity in the country.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Epilepsy, phytochemistry, plant anatomy, south-west Nigeria, tropical forest.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">96</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;A. Babalola Kadiri&lt;sup&gt;a&lt;/sup&gt;, O. Mawoussi Agboola&lt;sup&gt;a&lt;/sup&gt; and F. Olatunde. Fashina&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;b&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Department of Botany, University of Lagos, Akoka, Nigeria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Laboratory Services Unit, Nigerian Natural Medicine Development Agency, Lagos Nigeria.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Faramarz Majidi Wizneh</style></author><author><style face="normal" font="default" size="100%">Mohd Zaini Asmawi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Eurycoma longifolia Jack (Simarubaceae); Advances in Its Medicinal Potentials</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ergogenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Eurycomanone</style></keyword><keyword><style  face="normal" font="default" size="100%">Malaysian Ginseng</style></keyword><keyword><style  face="normal" font="default" size="100%">Pasak Bumi</style></keyword><keyword><style  face="normal" font="default" size="100%">Quassinoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Tongkat Ali</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">1-9</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Eurycoma longifolia&lt;/em&gt; Jack is a tall slender shrub-tree which is well-reputed among the natives of South East Asia for its potent aphrodisiac effect. Its root extracts have shown important biological activities such as antitumor, antimalarial, antibacterial, anti-diabetic, anti-hypertensive, Osteoprotective, and ergogenic which are mainly attributed to quassinoids. Commercially it is available in the form of drinks (along with other herbs), capsules, or loose powders. Based on available online databases it was realized that in spite of numerous reports on medicinal properties of E. longifolia, a review of recent developments regarding phytopharmacology, safety and toxicology, pharmacokinetics, and clinical applications was lacking. Therefore, this concise yet informative piece of work was prepared by pulling together trustworthy information from all the accessible published and unpublished scientific resources to serve as a reliable source of reference for future investigations.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Malaysian Ginseng, Eurycomanone, Tongkat Ali, Quassinoids, Ergogenic, Pasak Bumi.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Faramarz Majidi Wizneh&lt;sup&gt;*&lt;/sup&gt; and Mohd Zaini Asmawi&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang-11800, Malaysia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gunti Gowtham Raja,</style></author><author><style face="normal" font="default" size="100%">Hyma Sara Varghese,</style></author><author><style face="normal" font="default" size="100%">Sarita Kotagiri,</style></author><author><style face="normal" font="default" size="100%">Vrushabendra Swamy B.M</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of anti-cancer potential of aqueous extract of Pandanus odoratissimus (Y.Kimura) Hatus. forma ferreus, by in vivo ascitic tumor model in swiss albino mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Ehrlich ascites carcinoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Pandanus odoratissimus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">18th Feb,2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">57-62</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; India is a rich source of medicinal plants and number of plant extracts are used against diseases in various systems of medicine such as ayurveda, unani and siddha where only a few of them were scientifically explored. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of the present study was undertaken to perform dose dependent anti-cancer effect of aqueous and methanolic extracts of &lt;em&gt;P. odoratissimus&lt;/em&gt; roots and leaves whose scientific documentation for anti-tumor agent is lacking despite using traditionally. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The anti-cancer activity of methanolic extract of &lt;em&gt;P. odoratissimus&lt;/em&gt; (MEPO) and aqueous extract of &lt;em&gt;P. odoratissimus&lt;/em&gt; (AEPO) were tested against Ehrlich ascites carcinoma induced liquid tumors in swiss albino mice. The degree of protection was determined by change in body weight (gm), tumour volume (ml), packed cell volume (ml), cell viability (%), hematological parameters (R.B.C, W.B.C and hemoglobin content), mean survival time (MST), % increase in lifespan (% ILS) and histopathological observation of part of peritoneal layer.&lt;strong&gt; Results:&lt;/strong&gt; The treatment with AEPO 400 mg/kg, p.o. in EAC treated mice reduced tumor volume, packed cell volume, body weight, cell viability and improved all hematological parameters, mean survival time and life span. Histopathological changes showed degenerative changes of tumor cells in peritoneal layer. The anti-cancer effects of AEPO 400 mg/kg, p.o. are equally more with that of the standard drug cisplatin. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results suggested that aqueous extract of roots and leaves of &lt;em&gt;P. odoratissimus&lt;/em&gt; possess &lt;em&gt;in vivo&lt;/em&gt; anti-cancer activity comparable to cisplatin and this study scientifically validated the traditional use of this plant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Anticancer, &lt;em&gt;Pandanus odoratissimus&lt;/em&gt;, Ehrlich ascites carcinoma.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Gunti Gowtham Raj&lt;sup&gt;a&lt;/sup&gt;, Hyma Sara Varghese&lt;sup&gt;b&lt;/sup&gt;, Sarita Kotagiri&lt;sup&gt;c&lt;/sup&gt; and Vrushabendra Swamy B.M&lt;sup&gt;c&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Department of Pharmacology, Gautham College of Pharmacy, Sultanpalya, Bangalore, Karnataka &amp;ndash; 560 032, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Pharmacology, Hillside College of Pharmacy and Research centre, Raghuvanahalli, Bangalore, Karnataka &amp;ndash; 560 062, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;c&lt;/sup&gt;Department of Pharmacology, East point College of Pharmacy, Bangalore,Karnataka &amp;ndash; 560 049, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bhanu Priya,</style></author><author><style face="normal" font="default" size="100%">Manoj Gahlot,</style></author><author><style face="normal" font="default" size="100%">Punam Joshi,</style></author><author><style face="normal" font="default" size="100%">Sarika Zade,</style></author><author><style face="normal" font="default" size="100%">Ujwala Bagmar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti-Diabetic Activity of Methanolic Extract from the Leaves of Rotula Aquatica Lour in Alloxan-Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alloxan</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Glibenclamide</style></keyword><keyword><style  face="normal" font="default" size="100%">Rotula aquatica lour.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">18th Feb,2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">110-114</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The objective of the present study was to evaluate the anti-diabetic activity of methanolic extract from the leaves of &lt;em&gt;Rotula aquatica lour&lt;/em&gt; in Alloxan-induced diabetic rats.&lt;strong&gt; Materials and Methods: &lt;/strong&gt;Diabetes was induced in rat by injection of Alloxan (120 mg/kg, i.p.). Diabetic rats were divided into different groups and methanolic leaves extract of &lt;em&gt;Rotula aquatica lour&lt;/em&gt; (RA-ME) was administered at dose ranges of 100&amp;ndash;400 mg/kg, p.o for 21 days. Control group received normal saline (0.9%) for 21 days. Glibenclamide (5 mg/kg, p.o) was used as standard drug. Blood samples were collected from all the groups and analyzed for serum glucose and lipid levels such as total cholesterol (TC), triglyceride (TG), proteins (TP). RA-ME was also tested for oral glucose tolerance test (OGTT) in normal fasted rats. &lt;strong&gt;Results:&lt;/strong&gt; RA-ME (400 mg/kg, p.o) showed a significant (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.01) reduction of serum glucose level in Alloxan-induced diabetic mice as compared with diabetic control. RA-ME (200 and 400 mg/kg) also showed a significant reduction in serum TC, TG, and TP levels in Alloxan-induced diabetic rats. RA-ME (200 and 400 mg/kg, p.o) significantly (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.01) increased the glucose tolerance in OGTT. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results obtained from the present study revealed the potential anti-diabetic activity of methanolic extract from the leaves of &lt;em&gt;Rotula aquatica lour&lt;/em&gt;.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Alloxan, Anti-diabetic, Glibenclamide, &lt;em&gt;Rotula aquatica lour&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">110</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Bhanu Priya&lt;sup&gt;*,1&lt;/sup&gt;, Manoj Gahlot&lt;sup&gt;2&lt;/sup&gt;, Punam Joshi&lt;sup&gt;2&lt;/sup&gt;, Sarika Zade&lt;sup&gt;1&lt;/sup&gt; and Ujwala Bagmar&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Deptt of Pharmaceutical Chemistry, Sitabai Thite College of Pharmacy, Shirur, Pune-412210 (India)&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Deptt of Pharmaceutical Chemistry, S.G.R.R.I.T.S, Patel Nagar, Dehradun (Uttarakhand) India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">K. N. Mahesh,</style></author><author><style face="normal" font="default" size="100%">M. N. Wickramaratne,</style></author><author><style face="normal" font="default" size="100%">D. B. M. Wickramaratne</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antioxidant Activity of Five Medicinal Plants in Sri Lanka.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant Activities</style></keyword><keyword><style  face="normal" font="default" size="100%">Ascorbic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">8th April 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">49-54</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;This study investigated on the antioxidant properties of five medicinal plants used in Sri Lanka, namely &lt;em&gt;Solanum nigrum&lt;/em&gt;, &lt;em&gt;Amaranthus spinosus&lt;/em&gt;, &lt;em&gt;Elephantopuss caber&lt;/em&gt;, &lt;em&gt;Amorphophallus campanulatus&lt;/em&gt; and &lt;em&gt;Canna indica&lt;/em&gt;. The cold methanol plant extracts were screened for the antioxidant activity evaluating their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical in scavenging ability. The total ascorbic acid content of the extracts was also evaluated. The IC&lt;sub&gt;50 &lt;/sub&gt;values of the extracts revealed that &lt;em&gt;Solanum nigrum&lt;/em&gt; had the best DPPH scavenging activity with a value of 37.63 &amp;plusmn; 0.11&amp;mu;g/ml and was better than that of the standard ascorbic acid. &lt;em&gt;Amorphophallus campanulatus&lt;/em&gt; extract gave the highest ascorbic acid content of 143.03 &amp;plusmn; 1.97 mg per 100 g of the extract. All five plants extract showed DPPH scavenging activity in the order of Solanum nigrum &amp;gt; &lt;em&gt;Elephantopus scaber&lt;/em&gt;&amp;gt; &lt;em&gt;Amorphophallus campanulatus&lt;/em&gt;&amp;gt; &lt;em&gt;Canna indica&lt;/em&gt;. The plant extracts did not show a direct correlation between the ascorbic acid content to the DPPH scavenging activity. These experimental results reveals that these extracts can be utilized in future as therapeutic agent against free radical induced oxidative stress.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Antioxidant activities, Ascorbic acid, DPPH, Medicinal Plants.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;K. N. Mahesh&lt;sup&gt;1&lt;/sup&gt;, M. N. Wickramaratne&lt;sup&gt;2&lt;/sup&gt; and D. B. M. Wickramaratne&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Allied Health Sciences University of Peradeniya Sri Lanka&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physical Sciences and Technology Faculty of Applied Sciences Sabaragamuwa University of Sri Lanka.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">S. A. Thube</style></author><author><style face="normal" font="default" size="100%">M. J. Patil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Wound Healing Potential of Some Indian Herbal Extracts and it’s Formulation in Acne Vulgaris</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acne</style></keyword><keyword><style  face="normal" font="default" size="100%">excision model</style></keyword><keyword><style  face="normal" font="default" size="100%">incision model</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2nd July 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">37-46</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt;&lt;em&gt;Butea monosperma&lt;/em&gt;, &lt;em&gt;Barleria prionitis&lt;/em&gt;, &lt;em&gt;Casuarina equisetifolia&lt;/em&gt;, &lt;em&gt;Dalbergia sissoo&lt;/em&gt;, and &lt;em&gt;Lagenaria siceraria&lt;/em&gt; are reported to possess anti-acne, anti-infl ammatory, anti-ulcer, and wound healing activity. The present work is aimed at evaluating the wound healing potential of these plant materials in acne vulgaris. &lt;strong&gt;Methodology:&lt;/strong&gt; Individual gel formulations containing extracts of the above mentioned drugs and their polyherbal gels were evaluated by excision and incision wound model (&lt;em&gt;in vivo&lt;/em&gt;) in Sprague Dawley rats.&lt;strong&gt; Results:&lt;/strong&gt; The individual gel formulations showed signifi cant reduction in wound size when compared with the untreated group. The rates of wound closure after the application of the gels were compared with the untreated wounds. The polyherbal formulation containing all the extracts was found to be more benefi cial when compared to remaining treated groups. Healing under scab and formation of normal epithelial cells were better than other individual formulations. As well as vascular changes, cellular infi ltration, and necrosis were found less. &lt;strong&gt;Conclusion:&lt;/strong&gt; From the results, it may be concluded that the plants are endowed with signifi cant wound healing activity, thereby justifying its traditional medicinal use in acne vulgaris as a separate entity and in combination. Chemical components such as tannins, fl avonoids, saponins, and alkaloids present in the extracts can be responsible for the foresaid activity.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Acne, excision model, incision model, wound healing.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;S. A. Thube&lt;sup&gt;1*&lt;/sup&gt;, M. J. Patil&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, M.C.E. Society&amp;rsquo;s Allana College of Pharmacy, Pune, Maharashtra, India,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, M.M&amp;rsquo;s College of Pharmacy, Tathawade, Pune, Maharashtra, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kiruthika Dhanraj</style></author><author><style face="normal" font="default" size="100%">Renuka Saravanan</style></author><author><style face="normal" font="default" size="100%">Sheik Abdulla Shahul Hameed</style></author><author><style face="normal" font="default" size="100%">Sivakumar Ramalingam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anticancer Potential of Vitus vinifera Seed Against Breast Cancer Cells - MDA-MB-231</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA-MB-231</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitus vinifera seed</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1064-1071</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The aim of the present research is to evaluate the anti-cancer effect of &lt;em&gt;Vitus vinifera &lt;/em&gt;seed on MDA-MB-231 cell line. &lt;strong&gt;Methods: &lt;/strong&gt;The &lt;em&gt;Vitus vinifera &lt;/em&gt;(Grape) seed were dried, powdered and subjected to methanol, chloroform and ethyl acetate extraction by cold maceration followed by preliminary phytochemical screening. The extracts of &lt;em&gt;Vitus vinifera &lt;/em&gt;seed were subjected to assess anti-oxidant status, anti-proliferative activity by MTT assay, GC-MS analysis and apoptotic effect by determining LDH activity on MDA-MB-231. &lt;strong&gt;Results: &lt;/strong&gt;Results indicated that methanolic extract of grape seed showed appreciable anti-oxidant and anti-cancer potential compared with other two extracts. GC-MS mass spectrum of methanolic extract of seed revealed the presence of Dotriacontane, Linoleic acid and Decanoic acid ethyl ester, 1,2,3, propenetriol, monocetate, and Dichloro methyl propane sulfone were detected. &lt;strong&gt;Conclusion: &lt;/strong&gt;The data obtained in this work could be useful as a chemical standard in checking the genuineness of this plant source. Data of the results further depicted that the selected traditional &lt;em&gt;Vitus vinifera &lt;/em&gt;seed could be used not only as a potential anti-cancer and good antioxidant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1064</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kiruthika Dhanraj, Renuka Saravanan, Sheik Abdulla Shahul Hameed, Sivakumar Ramalingam*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Chemistry and Biosciences, SASTRA Deemed to be University, Srinivasa Ramanujam Centre, Kumbakonam 612001, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record></records></xml>