<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">B. Samuel Thavamani</style></author><author><style face="normal" font="default" size="100%">Vanitha Subburaj</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Studies on Basella rubra Different Extracts as Inhibitors of Key Enzymes Linked to Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Basella rubra</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Postprandial hyperglycemia</style></keyword><keyword><style  face="normal" font="default" size="100%">α-Amylase inhibitory activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">107-111</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Enzyme, inhibiting carbohydrate metabolism and thereby decreasing glucose level is a class of drugs helpful in the management of type 2 Diabetes mellitus. Naturally existing &amp;alpha;-amylase and &amp;alpha;-glucosidase inhibitors from medicinally significant plants are shown to be effective in the management of postprandial hyperglycemia. In this investigation, leaf extract (BRLE), stem extract (BRSE), fruit extract (BRFRE) and flower extract (BRFLE) of &lt;em&gt;Basella rubra &lt;/em&gt;were subjected to evaluate their antioxidant potential and their possible inhibitory effects on &amp;alpha;-amylase and &amp;alpha;-glucosidase. BRLE, BRSE, BRFRE, BRFLE (at concentration 100&amp;mu;g/ml) exhibited 65.78, 56.84, 63.1, 61.03% of &amp;alpha;-amylase inhibitory activity respectively with IC&lt;sub&gt;50&lt;/sub&gt; values of 71.66, 89.69, 73.68, 80.37 &amp;mu;g/ml respectively. In the same way BRLE, BRSE, BRFRE, BRFLE (at concentration 100 &amp;mu;g/ml) exhibited 97.63, 92.79, 82.17, 92.71 % of &amp;alpha;-glucosidase inhibition with an IC&lt;sub&gt;50&lt;/sub&gt; value of 26.97, 28.53, 41.30, 38.80 &amp;mu;g/ml respectively. Among the samples, the leaf extract of &lt;em&gt;B. rubra&lt;/em&gt; registered higher content of total phenolics and flavonoids and also higher antioxidant activity in DPPH, nitric oxide and NBT radical scavenging assays. Though all the parts had shown potent inhibitory effects on &amp;alpha;-amylase and &amp;alpha;-glucosidase, the highest inhibitory potency was observed in the leaf extract of &lt;em&gt;Basella rubra&lt;/em&gt;&amp;nbsp;(p&amp;lt;0.001).&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">107</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;B. Samuel Thavamani&lt;sup&gt;1&lt;/sup&gt;* and Vanitha Subburaj&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Sanjo College of Pharmaceutical Studies, Vellapara, Chithali P.O., Kuzhalmannam, Palakkad 678702, Kerala, India.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamilnadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tushar Kanti Bera,</style></author><author><style face="normal" font="default" size="100%">Kausik Chatterjee,</style></author><author><style face="normal" font="default" size="100%">Debidas Ghosh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Alpha glucosidase inhibitory activity of hydro-methanolic (2:3) extract of seed of Swietenia mahagoni (L.) Jacq</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">a-glucosidase</style></keyword><keyword><style  face="normal" font="default" size="100%">Postprandial hyperglycemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword><keyword><style  face="normal" font="default" size="100%">Total flavonoids</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">18th Feb,2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">63-69</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; Present study investigated the effect of hydro-methanolic extract of seed of Swietenia mahagoni (HMESM) on a-glucosidase inhibition in normal and streptozotocin-induced diabetic rats. &lt;strong&gt;Methods:&lt;/strong&gt; Oral carbohydrate tolerance tests were performed in 16h fasted normal and diabetic rats loaded with starch or sucrose or glucose at the dose of 3g/kg, 15min after administration of 250 (S1), 500 (S2), 1000 (S3) mg/kg of HMESM, vehicle (control),or pretreatment at the dose of 10 mg/kg of acarbose (Acar). Blood samples were analyzed for glucose levels at 0, 30&lt;sup&gt;th&lt;/sup&gt;, 60&lt;sup&gt;th&lt;/sup&gt;, and 120&lt;sup&gt;th&lt;/sup&gt; min after respective treatments and the peak blood glucose (PBG) levels and area under the curves (AUC) were determined. &lt;strong&gt;Results:&lt;/strong&gt; Results demonstrated that 500 mg, 1000 mg/kg of HMESM reduced and prolonged the PBG and decreased AUC simultaneously after starch and sucrose loading in normal and diabetic rats. Similarly acarbose also reduce the sucrose and starch induced blood glucose excursion, whereas it had no peak blood glucose suppressive effect after exogenous glucose load in both normal and diabetic rats. On the other hand, phytochemical study of the said extract revealed that it is rich in phenolic compounds (46.25 mg of gallic acid equivalent/g of extract) and flavonoids (231.72 mg of quercetin equivalent/g of the extract), which may may responsible for pharmacological activities. &lt;strong&gt;Conclusion: &lt;/strong&gt;The HMESM may have PBG suppressive effect in post-carbohydrate challenged state as evidenced by reduced PBG and AUC. This suggest that HMESM may be used effectively as a safer alternative to control postprandial hyperglycemia especially in pre-diabetic and diabetic patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Streptozotocin,∝-glucosidase, Postprandial hyperglycemia, Total flavono.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Tushar Kanti Bera,&lt;sup&gt;1,2&lt;/sup&gt; Kausik Chatterjee&lt;sup&gt;1&lt;/sup&gt; and Debidas Ghosh&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Bio-Medical Laboratory Science and Management, Vidyasagar University, Midnapur-721 102, West Bengal, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Division, Southern Health Improvement Samity (SHIS), South 24 Paraganas, Bhangar-743 502, West Bengal, India.&lt;/p&gt;</style></auth-address></record></records></xml>