<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raysa Y. Pratiwi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Heri Setiawan</style></author><author><style face="normal" font="default" size="100%">Atini Solawati</style></author><author><style face="normal" font="default" size="100%">Rosmalena</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Alterations in Body Weight, Blood Glucose Levels, and Lipid Profiles in High-Fat Diet-Low Dose Streptozotocin-Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetic animal model</style></keyword><keyword><style  face="normal" font="default" size="100%">High-fat diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin resistance</style></keyword><keyword><style  face="normal" font="default" size="100%">Low-dose streptozotocin</style></keyword><keyword><style  face="normal" font="default" size="100%">Stable diabetes type 2 profile.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1562-1567</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;New preventive and therapeutic strategies to treat Type 2 diabetes (T2D) continue to be pursued, the complexity of this disease makes it imperative to establish preclinical animal models which must provide accurate similarities to the pathogenesis of diabetes in humans. Making a diabetic animal model using rats with high-fat diet (HFD)-streptozotocin (STZ) induction is popular because it is relatively low cost and simple. &lt;strong&gt;Objectives:&lt;/strong&gt; This study aims to analyse the changes in body weight, blood glucose, and lipid profiles that occur in diabetic rat models created by induction of HFD in combination with lowdose STZ. &lt;strong&gt;Methods: &lt;/strong&gt;This study used forty male Sprague-Dawley rats (200-240 g). After the adaptation period, thirty rats were fed with HFD for 28 days (DM group), while the other ten rats continued to be fed with standard feed (NC group). After then, diabetes was induced to the DM group by low-dose STZ (35 mg/kg BW). The body weight of the rats was measured before and after diet manipulation periods. Blood samples were taken before and after STZ induction to determine lipid profiles and blood glucose levels.&lt;strong&gt; Results:&lt;/strong&gt; During the diet manipulation period, the HFD group experienced a significantly greater weight gain, higher blood glucose levels, and cholesterol (TC) levels. After STZ injection, rats’ blood glucose levels, TC, and triglycerides significantly increased.&lt;strong&gt; Conclusion:&lt;/strong&gt; HFD feeding combined with a low-dose STZ effectively work to mimic specific condition that is similar to T2D, and the stability of the experimental animal conditions remains constant for up to 6 weeks.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1562</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Raysa Y. Pratiwi&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1&lt;/sup&gt;,&lt;sup&gt;*&lt;/sup&gt;, Heri Setiawan&lt;sup&gt;1&lt;/sup&gt;, Atini Solawati&lt;sup&gt;1&lt;/sup&gt;, Rosmalena&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Iram Nazish</style></author><author><style face="normal" font="default" size="100%">S H Ansari</style></author><author><style face="normal" font="default" size="100%">Poonam Arora</style></author><author><style face="normal" font="default" size="100%">Adil Ahmad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiobesity activity of Zingiber officinale</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">High-fat diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin.</style></keyword><keyword><style  face="normal" font="default" size="100%">Leptin</style></keyword><keyword><style  face="normal" font="default" size="100%">Rat</style></keyword><keyword><style  face="normal" font="default" size="100%">Zingiber officinale</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">440-446</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context: &lt;/strong&gt;&lt;em&gt;Zingiber officinale&lt;/em&gt; Roscoe (Zingiberaceae) rhizome, known commonly as ginger is extensively used in Indian traditional system of medicine for treatment of various disorders. The ethanolic &lt;em&gt;Z. officinale&lt;/em&gt; extract is reported to have various activity such as antidiabetic, antihyperlipidemic and antioxidant activity in experimental animals. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate anti-obesity effect of aqueous &lt;em&gt;Z. officinale&lt;/em&gt; extract in murine model of high fat diet (HFD)- induced obesity. Materials and Methods: Male Wistar rats fed with HFD (20 g/day/rat, p.o) for a period of 42 days were used to induce obesity. Aqueous&lt;em&gt; Z. officinale&lt;/em&gt; extract (20 mg/kg b.w.) administered orally to HFD fed rats from day 8 to 50 days for a period of 42 days. Body weight gain, serum lipids, insulin and leptin parameters were measured. &lt;strong&gt;Results:&lt;/strong&gt; Oral feeding of the aqueous&lt;em&gt; Z. officinale&lt;/em&gt; extract (20 mg/kg) to HFD-induced obese rats for a period of 42 days resulted in significant reduction in body weight gain, insulin, leptin, lipids as compared to rats fed HFD alone. Further, the extract also showed significant increase in high density lipoprotein (HDL-C) levels.&lt;strong&gt; Discussion and Conclusion:&lt;/strong&gt; These results show that aqueous&lt;em&gt; Z. officinale&lt;/em&gt; extract possess significant anti-obesity potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">440</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Iram Nazish&lt;sup&gt;*1&lt;/sup&gt;, S H Ansari&lt;sup&gt;2&lt;/sup&gt;, Poonam Arora&lt;sup&gt;2&lt;/sup&gt;, Adil Ahmad&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, HK College of Pharmacy, Oshiwara, Mumbai, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Hamdard University, Hamdard Nagar, New Delhi, INDIA.&lt;/p&gt;
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