<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manjunath Shivaram Shetty</style></author><author><style face="normal" font="default" size="100%">Arul Amuthan</style></author><author><style face="normal" font="default" size="100%">K Ganesh Shenoy</style></author><author><style face="normal" font="default" size="100%">Amruth Kiran</style></author><author><style face="normal" font="default" size="100%">Vasudev R Pai</style></author><author><style face="normal" font="default" size="100%">Vasudha Devi</style></author><author><style face="normal" font="default" size="100%">Nitesh Kumar</style></author><author><style face="normal" font="default" size="100%">Govindasamy Suresh</style></author><author><style face="normal" font="default" size="100%">M Hariprasad Kamath</style></author><author><style face="normal" font="default" size="100%">Devasrita Dash</style></author><author><style face="normal" font="default" size="100%">Tatiyana Mandal</style></author><author><style face="normal" font="default" size="100%">Bhisham Narayan Singh</style></author><author><style face="normal" font="default" size="100%">Smita Shenoy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comprehensive Quality Assessment of Siddha Polyherbal Tablet Kadukkai Maathirai: HPLC Analysis, Iron Estimation, Heavy Metal Screening, and Microbial Contamination Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Heavy metal screening</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality assessment</style></keyword><keyword><style  face="normal" font="default" size="100%">Siddha herbal tablets</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">309-314</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The global use of herbal drugs for liver diseases is on the rise, driven by increasing rates of liver-related ailments. Despite their widespread use, growing concerns have been raised about the safety and quality of herbal formulations. The present study assessed Kadukkai Maathirai (KM), a Siddha-based polyherbal preparation, for potential contamination with heavy metals and microbial agents. Samples of KM procured from the SKM Company and then analyzed for microbial contamination and for the presence of heavy metals. The findings depicted that the heavy metals, such as arsenic (As), Cadmium (Cd) and Lead (Pb), were in permissible limits. Moreover, microbial analysis revealed no detectable growth on culture plates, indicating the absence of bacterial and fungal contamination in the KM samples. In addition, when the samples were analysed for Marker compounds, the chebulic acid content in the hydroalcoholic extract was determined to be 1.13% w/w. The current findings of the study support the safety of KM for therapeutic use. The herbal medicine standardization and the integration of present analytical tools with traditional knowledge may enhance therapeutic reliability of the patients using it. Clinical studies are essential to validate KM’s efficacy in liver diseases and support its incorporation into evidence-based medical practice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">309</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Manjunath Shivaram Shetty&lt;sup&gt;a&lt;/sup&gt;, Arul Amuthan&lt;sup&gt;a,b&lt;/sup&gt;, K Ganesh Shenoy&lt;sup&gt;a&lt;/sup&gt;, Amruth Kiran&lt;sup&gt;a&lt;/sup&gt;, Vasudev R Pai&lt;sup&gt;c&lt;/sup&gt;, Vasudha Devi&lt;sup&gt;a&lt;/sup&gt;, Nitesh Kumar&lt;sup&gt;d&lt;/sup&gt;, Govindasamy Suresh&lt;sup&gt;a&lt;/sup&gt;, M Hariprasad Kamath&lt;sup&gt;e&lt;/sup&gt;, Devasrita Dash&lt;sup&gt;a&lt;/sup&gt;, Tatiyana Mandal&lt;sup&gt;a&lt;/sup&gt;, Bhisham Narayan Singh&lt;sup&gt;f&lt;/sup&gt;, Smita Shenoy&lt;sup&gt;g,*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal, 576104, India&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Division of Siddha, Center for Integrative Medicine and Research (CIMR), Manipal Academy of Higher Education, Manipal, 576104, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;c&lt;/sup&gt;Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;d&lt;/sup&gt;Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, 844102, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;e&lt;/sup&gt;Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal – 576104, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;f&lt;/sup&gt;Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;g&lt;/sup&gt;Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104, INDIA.&lt;/p&gt;
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