<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pallab Kar</style></author><author><style face="normal" font="default" size="100%">Ayodeji O. Oriola</style></author><author><style face="normal" font="default" size="100%">Adebola O. Oyedeji</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Natural Flavonoid Glycoside-Based Zinc Oxide Nanoparticles: Compound Isolation, Nanoparticle Green Synthesis, Characterization, and in vitro Antioxidant, Anti-hyperglycaemic and Anti-inflammatory Effects</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">antihyperglycaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Green synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">natural flavonoid glycosides</style></keyword><keyword><style  face="normal" font="default" size="100%">ZnO Nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">531-541</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Recent advances in effective and efficient drug delivery have favoured the biological applications of phytochemical-based metal oxide nanoparticles (NPs). Objective: This study, therefore, utilized a flavonoid glycoside, Myricitrin (MY), isolated from &lt;em&gt;Eugenia uniflora &lt;/em&gt;as a biogenic substance for the synthesis of zinc oxide nanoparticles (ZnONPs) and evaluated the antioxidant, anti-hyperglycaemic, and anti-inflammatory potentials. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Flavonoid glycoside was isolated from the leaf of &lt;em&gt;E. uniflora&lt;/em&gt; following standard phytochemical techniques for extraction, solvent-partitioning, column chromatography, and thin-layer chromatography. The phytocompound was characterized by NMR and HRESI-MS methods. Zinc oxide NPs were green synthesized using the isolated flavonoid glycoside. The biogenic ZnONPs were characterized using UV-Vis, FESEM, EDX, and XRD techniques. The biological potential of the MY-ZnONPs was based on in vitro analysis. Nitric oxide (NO), H2O2, OH, and O2 - antioxidant methods were used. The anti-hyperglycaemic effect was based on α-amylase and α-glucosidase enzyme inhibition, while the egg albumin denaturation (EAD) method was used to determine the antiinflammatory effect. &lt;strong&gt;Results:&lt;/strong&gt; Flavonoid glycoside was isolated and characterized as myricitrin from &lt;em&gt;E. uniflora&lt;/em&gt;. The MY-ZnONPs were green synthesized as a greyish powder. The UV-Vis absorption peaks at 387 and 415 nm match the characteristic peaks for ZnONPs. The FESEM revealed petal-, irregular-, and spindle-shaped NPs of 30-80 nm size, which tend to agglomerate in clusters and bundles. The EDX analysis showed the elemental weight percentage of Zn and O to be 79.83% and 18.51%, respectively, indicating the successful formation of ZnO nanoparticles. The X-ray diffractogram showed the crystallinity of the NPs at 29.23⁰, 36.25⁰, 51.50⁰, 63.67⁰, 72.06⁰, and 78.90⁰. At 100 μg/mL, the NPs demonstrated a comparable 68% inhibition of O&lt;sub&gt;2&lt;/sub&gt; - to Quercetin, the standard antioxidant. They inhibited EAD in a dose-de pendent manner, having ≥75% inhibition at 200 μg/mL. Finally, they exhibited notable anti-hyperglycaemic properties against α-amylase and α-glucosidase with IC&lt;sub&gt;50&lt;/sub&gt; of 89.24±0.63 and 105.95±0.05 μg/mL, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study has shown MY-ZnONPs as a flavonoid glycoside-based metal oxide nanoparticle with notable antioxidant, anti-diabetic, and anti-inflammatory activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">531</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Pallab Kar&lt;sup&gt;1,*&lt;/sup&gt;, Ayodeji O. Oriola&lt;sup&gt;2,*&lt;/sup&gt;, Adebola O. Oyedeji&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;African Medicinal Flora and Fauna Research Niche Area, Walter Sisulu University Nelson Mandela Drive, P/Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemical and Physical Sciences, Walter Sisulu University, Nelson Mandela Drive, P/ Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;
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