<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nandhinee Thiagaraj</style></author><author><style face="normal" font="default" size="100%">Lekha Ashokkumar</style></author><author><style face="normal" font="default" size="100%">Ram Sabarish</style></author><author><style face="normal" font="default" size="100%">Balaji SK</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In-silico Analysis of Molecular Interaction Between Silk Proteins with BMP-2 Type IA and Type II Receptors</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">biopolymer</style></keyword><keyword><style  face="normal" font="default" size="100%">Fibroin</style></keyword><keyword><style  face="normal" font="default" size="100%">HADDOCK</style></keyword><keyword><style  face="normal" font="default" size="100%">RMSD</style></keyword><keyword><style  face="normal" font="default" size="100%">Sericin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">378-383</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Alveolar ridge defects are commonly associated with delayed tooth replacement. Natural biomaterial with enhanced regenerative potential is always sought after as a primary choice for ridge reconstruction. Silk, a biopolymer with its constituent proteins (fibroin and sericin) has recently demonstrated promising outcomes in vitro. However, the molecular mechanism by which this occurs remains to be elucidated.&lt;strong&gt; Objective: &lt;/strong&gt;We assessed the molecular interactions between silk proteins bone morphogenetic protein (BMP)-2 type IA and type II receptors using molecular docking. &lt;strong&gt;Methodology:&lt;/strong&gt; The N-terminal domain of silk proteins and structural complex of BMP-2 type IA and type II receptors were considered for protein–protein docking using the high ambiguity-driven protein–protein docking (HADDOCK) server. HADDOCK scores are a measure of the predicted stability of the protein–protein complex, and a lower score indicates a more stable complex and a higher affinity for binding.&lt;strong&gt; Results: &lt;/strong&gt;The HADDOCK scores and root mean square deviation value for interaction between silk proteins with BMP-2 type IA and type II receptors were (−114.2 ± 25.0 and −143.1 ± 11.3) and (2.9 ± 0.4 and 1.9 ± 0.5), respectively, for fibroin and (−1.8 ± 15.6 and −9.7 ± 25.2) and (3.5 ±0.3 and 0.9 ± 0.6), respectively, for sericin. &lt;strong&gt;Conclusion: &lt;/strong&gt;The interaction between fibroin and BMP-2 receptors was more stable with higher affinity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">378</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nandhinee Thiagaraj, Lekha Ashokkumar*, Ram Sabarish, Balaji SK&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Periodontology, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;
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