<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ekta Panchal</style></author><author><style face="normal" font="default" size="100%">Shiv Kumar Yadav</style></author><author><style face="normal" font="default" size="100%">Neha Jain</style></author><author><style face="normal" font="default" size="100%">Mahima Chauhan</style></author><author><style face="normal" font="default" size="100%">Deepika Yadav</style></author><author><style face="normal" font="default" size="100%">Archana Sharma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Reversed-Phase- HPLC Method Development and Validation for Simultaneous Determination of Dexamethasone and Curcumin in Bulk Mixtures</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Curcumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Dexamethasone</style></keyword><keyword><style  face="normal" font="default" size="100%">Qualitative</style></keyword><keyword><style  face="normal" font="default" size="100%">Quantitative</style></keyword><keyword><style  face="normal" font="default" size="100%">RP-HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Validation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">221-228</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The combination of curcumin and dexamethasone can improve anti-inflammatory benefits, lower the dosage of corticosteroids needed, and offer a more comprehensive therapeutic strategy with fewer side effects in treating rheumatoid arthritis. &lt;strong&gt;Objective:&lt;/strong&gt; This research work aimed to develop a specific and reproducible RP (Reversed-Phase)–HPLC analytical method with a PDA detector for the qualitative and quantitative determination of dexamethasone and curcumin in a bulk mixture. &lt;strong&gt;Methods:&lt;/strong&gt; The RP technique was employed in which the HPLC instrument was equipped with a PDA detector and a C18 analytical column (250 × 4.6 mm, 5μm) at 30°C temperature. The mobile phase used in this work consisting 0.1 % Orthophosphoricacid: Acetonitrile at the specified ratio of 30:70 accompanied by a defined flowrate of 1mL/min with an injectionvolume of 10μL. The spectrum detected for the diluted simple solution at wavelength of 280nm using UV visible spectroscopy for good resolution. &lt;strong&gt;Results:&lt;/strong&gt; This method resulted in two distinct peaks of dexamethasone and curcumin with a retention time of 3.16 and 4.16minutes respectively and all studied parameters which ensure the suitability of the developed method were analyzed and fall within the aceptable criteria. The sensitivity was detected at 0.232μg/ml &amp;amp; 0.704μg/ ml, respectively, for dexamethasone while, for curcumin it was found to be 0.065μg/ml and 0.198μg/ml, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The validation methodology was developed by ICH guidelines for its linearity, accuracy, precision, robustness, LOD, &amp;amp; LOQ. From the results, it can be concluded that the developed method was found to be satisfactory in terms of reproducibility and accuracy. The chromatogram shows two distinct peaks for both drugs and further, it could be effectively utilized in the quantitative and qualitative estimation of both drugs for any pharmaceutical research.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">221</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ekta Panchal&lt;sup&gt;1, 2&lt;/sup&gt;, Shiv Kumar Yadav&lt;sup&gt;2*&lt;/sup&gt;, Neha Jain&lt;sup&gt;1&lt;/sup&gt;, Mahima Chauhan&lt;sup&gt;3&lt;/sup&gt;, Deepika Yadav&lt;sup&gt;2&lt;/sup&gt;, Archana Sharma&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Amity Institute of Pharmacy, Amity University Uttar Pradesh, Sector 125, Noida 201303, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Anangpuria School of Pharmaceutical Sciences, Pt. B. D. Sharma University of Health Sciences, Alampur, Faridabad121004, Haryana, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;HIMT College of Pharmacy College, Greater Noida, Uttar Pradesh, 201301, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Harris Kristanto Gunawan</style></author><author><style face="normal" font="default" size="100%">Evelyn Komaratih</style></author><author><style face="normal" font="default" size="100%">Rozalina Loebis</style></author><author><style face="normal" font="default" size="100%">Djoko Agus Purwanto</style></author><author><style face="normal" font="default" size="100%">Luki Indriaswati</style></author><author><style face="normal" font="default" size="100%">Wimbo Sasono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Asiatic Acid and Dexamethasone Effect on Interleukin-4 Expression and Eosinophile Cell Count Following Strabismus Surgery: An Experimental Study in New Zealand Rabbit</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asiatic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Dexamethasone</style></keyword><keyword><style  face="normal" font="default" size="100%">Eosinophil</style></keyword><keyword><style  face="normal" font="default" size="100%">Interleukin-4</style></keyword><keyword><style  face="normal" font="default" size="100%">Strabismus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1411-1417</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Postoperative strabismus inflammation can lead to fibrotic tissue formation. Dexamethasone, while generally effective as an anti-inflammatory post-surgery medication, can increase IOP and blood sugar levels. Research on asiatic acid suggests its potential as an anti-inflammatory and anti-fibrotic agent. &lt;strong&gt;Methods:&lt;/strong&gt; Superior rectus recession was conducted on 20 rabbits, which were divided into five groups based on the subconjunctival injection substance: aquadest, dexamethasone, asiatic acid at a concentration of 0.4 mg/0.5 mL, 0.8 mg/0.5 mL, and 1.6 mg/0.5 mL. After three days, exenteration was performed, and an immunohistochemical examination was performed to assess interleukin-4 expression. Hematoxylin and eosin staining was performed to assess eosinophile cell count. SPSS 26.0 facilitated the data analysis using the Kruskal-Wallis and Wilcoxon Mann-Whitney tests. P&amp;lt;0.05 was considered significant statistically. &lt;strong&gt;Results:&lt;/strong&gt; This study showed that interleukin-4 expression in the asiatic acid 0.4 mg/0.5 mL group was significantly decreased compared to the aquadest group (P = 0.029) and dexamethasone group (P = 0.029). Higher-dose groups did not exhibit a significant decrease. Dexamethasone also did not exhibit a significant decrease compare to aquadest. There was no significant reduction of eosinophile cell count among all groups.&lt;strong&gt; Conclusions:&lt;/strong&gt; This study highlighted the potential of asiatic acid, particularly at the concentration of 0.4 mg/0.5 mL, in reducing the inflammatory response, specifically interleukin-4 expression, after strabismus surgery in New Zealand rabbits.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1411</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Harris Kristanto Gunawan&lt;sup&gt;1&lt;/sup&gt;, Evelyn Komaratih&lt;sup&gt;1*&lt;/sup&gt;, Rozalina Loebis&lt;sup&gt;1&lt;/sup&gt;, Djoko Agus Purwanto&lt;sup&gt;2&lt;/sup&gt;, Luki Indriaswati&lt;sup&gt;1&lt;/sup&gt;, Wimbo Sasono&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Ophthalmology, Dr. Soetomo General Academic Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
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