<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meilla Dwi Andrestian</style></author><author><style face="normal" font="default" size="100%">Rizal Damanik</style></author><author><style face="normal" font="default" size="100%">Faisal Anwar</style></author><author><style face="normal" font="default" size="100%">Nancy Dewi Yuliana</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extract of Torbangun (Coleus amboinicus Lour) Leaves Inhibits  the Expression of PEPCK and G6Pase in Streptozotocin-Induced  Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">G6Pase</style></keyword><keyword><style  face="normal" font="default" size="100%">hyperglycemia</style></keyword><keyword><style  face="normal" font="default" size="100%">PEPCK</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Torbangun</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1116-1120</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to analyze the anti-hyperglycemic activity of Torbangun leaf extract (TLE) in hyperglycemic rats by observing its effect on blood glucose levels and &lt;em&gt;PEPCK &lt;/em&gt;and &lt;em&gt;G6Pase&lt;/em&gt; gene expression. &lt;strong&gt;Method:&lt;/strong&gt; This post-test-controlled group design study used a completely randomized design (CRD). Seven rats were separated as a normal group (N) and other rats were injected with streptozotocin (STZ). Hyperglycemia was characterized by fasting blood glucose (FBG) &amp;gt;126 mg/dl. Hyperglycemic rats were divided into three groups: H-IM (control drug metformin hydrochloride dose 62.5 mg/kg BW), H-IT (TLE dose 620mg/kg BB), and NG (negative control, hyperglycemic rats). Rats were given intervention for 14 days.&lt;strong&gt; Result:&lt;/strong&gt; The results showed a significant difference between initial and final FBG of the HI-IM group (p = 0.002, α = 0.01) and the H-IT group (p = 0.005, α = 0.01) and effect on the key gene expression of gluconeogenesis in the liver. The H-IT group showed a decrease in PEPCK gene expression 0.80 times and decreased G6Pase gene expression by 0.65 times compared to NG group. &lt;strong&gt;Conclusion:&lt;/strong&gt; The findings suggested the administration of TLE in STZ-induced hyperglycemic rats was able to reduce blood sugar levels and was involved in inhibiting the expression of PEPCK and G6Pase expression genes in the liver.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1116</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Meilla Dwi Andrestian&lt;sup&gt;1,*&lt;/sup&gt;, Rizal Damanik&lt;sup&gt;2,3&lt;/sup&gt;, Faisal Anwar&lt;sup&gt;2&lt;/sup&gt; , Nancy Dewi Yuliana&lt;sup&gt;4&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Nutrition, Polytechnic of Health Ministry of Health Banjarmasin, Banjarbaru, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Community Nutriton, Faculty of Human Ecology, IPB University, Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Southeast Asian Food and Agricultural Science and Technology (SEAFAST) Center Bogor, IPB University, Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Food Science, Faculty of Agricultural Agricultural Engineering and Technology, IPB University, Bogor, INDONESIA.&lt;/p&gt;
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