<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Alejandro Arroyo-Sandoval</style></author><author><style face="normal" font="default" size="100%">Manuel Jesús Marin-Bravo</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Roberto Jesús Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Javier Hernán Chávez-Espinoza</style></author><author><style face="normal" font="default" size="100%">Jaime David Torres-Lévano</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacobotany, Phytochemical Analysis and Anti-inflammatory effect of the Ethanolic Extract of Luffa operculata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory.</style></keyword><keyword><style  face="normal" font="default" size="100%">Luffa operculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">622-628</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Luffa operculata&lt;/em&gt; is a vegetable species well known in the traditional peruvian medicine for its many medicinal properties and cosmetic applications.&lt;strong&gt; Objective: &lt;/strong&gt;The aim objective was to determine the pharmacognostic characteristics of&lt;em&gt; L. operculata&lt;/em&gt; as well as observing the pharmacological effect of the ethanol extract of &lt;em&gt;L. operculata&lt;/em&gt; fruit on chronic inflammation in rats. &lt;strong&gt;Materials and Method&lt;/strong&gt;: Phytochemical analysis was carried out by using specific chemical reagents for each constituent chemical, the pharmacobotanical study was done with a histological tinction (fruit, steam and leaves), which were stained with Safranin 1% and Toluidine blue 1%; the chronical inflammation was assessed by air bag method in Holztman male rats. Doses of 100, 250 and 500 mg/Kg were tested in order to determine the anti-inflammatory effect, which was demonstrated with histopathological evaluation and lymphocytes reduction. &lt;strong&gt;Results: &lt;/strong&gt;The main findings indicate that the ethanolic extract presented saponins, alkaloids, carbohydrates, terpenes and steroids. The efficiency of lymphocyte reduction per field in the histopathological study of the granuloma was 58.4% with the middle dose of 250 mg/kg (p &amp;lt; 0.0001), which gives a dose-independent anti-inflammatory effect in rats.&lt;strong&gt; Conclusion: &lt;/strong&gt;&lt;em&gt;Luffa operculata &lt;/em&gt;presented anti-inflammatory effect at 250 mg/Kg by oral administration in a chronical experimental model of inflammation in rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">20</style></accession-num><section><style face="normal" font="default" size="100%">622</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Alejandro Arroyo-Sandoval&lt;sup&gt;1&lt;/sup&gt;, Manuel Jesús Marin-Bravo&lt;sup&gt;2&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;3&lt;/sup&gt;, Hugo Jesús Justil-Guerrero&lt;sup&gt;3&lt;/sup&gt;, Roberto Jesús Chávez- Asmat&lt;sup&gt;4&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;5&lt;/sup&gt;, Javier Hernán Chávez-Espinoza&lt;sup&gt;5&lt;/sup&gt;, Jaime David Torres-Lévano&lt;sup&gt;6&lt;/sup&gt;, Eddie Loyola- Gonzales&lt;sup&gt;6&lt;/sup&gt;, José Santiago Almeida- Galindo&lt;sup&gt;7&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;8,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Chemistry and Chemical Engineering. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Plant Anatomy and Pharmacognosy. Faculty of Biology. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Section of Neurosurgery, Hospital São Vicente de Paulo. São Paulo, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Departament of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Desmond Ato Koomson</style></author><author><style face="normal" font="default" size="100%">Benjamin Danso Kwakye</style></author><author><style face="normal" font="default" size="100%">Williams Kweku Darkwah</style></author><author><style face="normal" font="default" size="100%">Bismark Odum</style></author><author><style face="normal" font="default" size="100%">Mabel Asante</style></author><author><style face="normal" font="default" size="100%">Gideon Aidoo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Constituents, Total Saponins, Alkaloids, Flavonoids and Vitamin C Contents of Ethanol Extracts of five Solanum torvum Fruits</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkaloids</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponins</style></keyword><keyword><style  face="normal" font="default" size="100%">Solanum torvum fruits</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">946-950</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Phytochemicals are frequently used in chemotherapeutic treatment or may be used as chemo preventive agents with chemoprevention. The study report the quantification of phytochemical constituents and vitamin C contents from ethanol extracts of Solanum torvum fruits. &lt;strong&gt;Method:&lt;/strong&gt; The main objective for this research was to use standard procedures to determine phytochemical and vitamin C content. &lt;strong&gt;Results:&lt;/strong&gt; The estimated alkaloids found in mature fruits were 6.32 &amp;plusmn; 0.12 mg/g and 16.94 &amp;plusmn; 2.3 mg/g in the immature fruits. Total saponins in mature and immature fruits were 8.60 &amp;plusmn; 2.6 mg/g and 16.90 &amp;plusmn; 9.4 mg/g respectively. Total flavonoids in mature and immature fruits were 21.14 &amp;plusmn; 4.4 mg/g and 14.24 &amp;plusmn; 1.8 mg/g respectively. Also vitamin C contents were 11.79 &amp;plusmn; 2.0 mg/g in mature fruits and 8.70 &amp;plusmn; 0.26 mg/g in immature fruits. With the exception of alkaloids whose difference in the mature and immature was significant, other differences obtained were not significant. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study showed that the extracts contain diversity of phytochemicals in appreciable amount that can expertly keep the body against oxidative stress triggered by free radicals and therefore be used as a source of potent natural products.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">946</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Desmond Ato Koomson&lt;sup&gt;1&lt;/sup&gt;, Benjamin Danso Kwakye&lt;sup&gt;2&lt;/sup&gt;, Williams Kweku Darkwah&lt;sup&gt;1,3&lt;/sup&gt;*, Bismark Odum&lt;sup&gt;3,4&lt;/sup&gt;, Mabel Asante&lt;sup&gt;5&lt;/sup&gt;, Gideon Aidoo&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, GHANA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Mathematics, College of Science, Hohai University, Nanjing, CHINA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education, Environmental Engineering Department, College of Environment, Hohai University, Nanjing, CHINA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Chemical Engineering Department, College of Engineering, Kwame Nkrumah University of Science and Technology, Kumasi, GHANA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Laboratory Technology, School of Physical Sciences, University of Cape Coast, Cape Coast, GHANA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Clinical Research Laboratory Department, 37-Military Teaching Hospital, Accra , GHANA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tanayen Julius Kihdze</style></author><author><style face="normal" font="default" size="100%">Ajayi Abayomi Mayowa</style></author><author><style face="normal" font="default" size="100%">Oloro Joseph</style></author><author><style face="normal" font="default" size="100%">Ezeonwumelu Joseph OC</style></author><author><style face="normal" font="default" size="100%">Tanayen Grace Ghaife</style></author><author><style face="normal" font="default" size="100%">Adzu Bulus</style></author><author><style face="normal" font="default" size="100%">Arthur van Aerschot</style></author><author><style face="normal" font="default" size="100%">Gert Laekeman</style></author><author><style face="normal" font="default" size="100%">Agaba Amon Ganafa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical and Antidiabetic Evaluation of the Methanolic Stem Bark Extract of Spathodea campanulata (P. Beauv.) Bignoniaceae</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponins</style></keyword><keyword><style  face="normal" font="default" size="100%">Spathodea campanulata (P. Beauv.) Bignoniaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">TLC Tannins</style></keyword><keyword><style  face="normal" font="default" size="100%">Uganda.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">243-249</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: &lt;em&gt;Spathodea campanulata (P. Beauv.) Bignoniaceae &lt;/em&gt;extract&amp;nbsp;(SCE) is one of many herbal medicines&amp;nbsp;used widely in Ugandan traditional&amp;nbsp;medicine for various ailments. Generally most of these herbal&amp;nbsp;medicines&amp;nbsp;are yet to be standardized or have their phytochemical content characterized.&amp;nbsp;&lt;strong&gt;Method: &lt;/strong&gt;This study identified the secondary metabolites in the stem bark&amp;nbsp;methanolic extract and quantified them. The same extract was subjected&amp;nbsp;to serial solvent fractionation, TLC characterization and antidiabetic testing.&amp;nbsp;&lt;strong&gt;Results: &lt;/strong&gt;The secondary metabolites were found to comprise of 7.5% alkaloids,&amp;nbsp;10% flavonoids, 13% tannins and 17% saponins per gram of plant material.&amp;nbsp;The TLC characteristics of the fractions (hexane (HX), ethylacetate (EA)&amp;nbsp;and methanol (ME)) viewed under UV light revealed spots with the following&amp;nbsp;Rf values; the hexane partition gave HX7EA3 (0.96 and 0.68) HX9EA1&amp;nbsp;(0.68 and 0.3), EA1ME9 (0.86 and 0.58), EA3ME7 (0.87), EA7ME3 (0.85)&amp;nbsp;and EA9ME1 (0.85). The ethylacetate partition gave the following HX1EA9 (0.53, 0.34 and 0.18), HX3EA7 (0.59, 0.40 and 0.26). &lt;strong&gt;Discussion: &lt;/strong&gt;All the&amp;nbsp;fractions produced nominal reduction of hyperglycemia. Except hexane&amp;nbsp;fraction at 50 mg/kg and ethylacetate fraction at 200 mg/kg all the fractions&amp;nbsp;had percentage reductions of glucose greater than that of the control at&amp;nbsp;the experimental doses. Although the values of percentage reductions of&amp;nbsp;hyperglycemia by the hexane fraction were apparently dose-dependent,&amp;nbsp;the greatest margin of reduction of hyperglycemia was observed in the&amp;nbsp;residual aqueous fraction. &lt;strong&gt;Conclusion: &lt;/strong&gt;It was found that SCE contains&amp;nbsp;valuable phytochemicals in appreciable quantities which are antidiabetic.&amp;nbsp;The residual aqueous fraction is the most potent antihyperglycemic of the&amp;nbsp;solvent fractions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">243</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Tanayen Julius Kihdze&lt;sup&gt;1,3&lt;/sup&gt;, Ajayi Abayomi Mayowa&lt;sup&gt;2,3&lt;/sup&gt;, Oloro Joseph&lt;sup&gt;1,3&lt;/sup&gt;, Ezeonwumelu Joseph OC&lt;sup&gt;3&lt;/sup&gt;, Tanayen Grace Ghaife&lt;sup&gt;5&lt;/sup&gt;, Adzu Bulus&lt;sup&gt;3,4&lt;/sup&gt;, Arthur van Aerschot&lt;sup&gt;6&lt;/sup&gt;, Gert Laekeman&lt;sup&gt;6&lt;/sup&gt;, Agaba Amon Ganafa&lt;sup&gt;1&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Therapeutics, Mbarara University of Science and Technology, P.O. Box 1410 Mbarara, UGANDA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, NIGERIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Kampala International University, Complementary and Alternative Medicine Research (KIU-CAMRES) group.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;National Institute for Pharmaceutical Research and Development (NIPRD) PMB 21 Abuja, NIGERIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Laboratory Sciences, Kampala International University Bushenyi, UGANDA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;KU Leuven&amp;ndash;University of Leuven, Department of Pharmaceutical and Pharmacological Sciences 3000 BELGIUM.&lt;/p&gt;
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