<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suryati</style></author><author><style face="normal" font="default" size="100%">Dira Hefni</style></author><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Dachriyanus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Cytotoxicity Study of Lantana camara Linn Essential Oil on HeLa Cancer Cells Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cervical cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrodistillation</style></keyword><keyword><style  face="normal" font="default" size="100%">Lantana camara</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1498-1501</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Lantana camara &lt;/em&gt;Linn (Verbenaceae) is a natural plant that thrives in tropical climates and is relatively easy to cultivate. In Indonesia, this plant is still often considered as a weed. When held, the unpleasant smell and sticky hand make people dislike this plant even though the flowers are diverse. The essential oil was extracted from the leaves of &lt;em&gt;L. camara&lt;/em&gt; by hydrodistillation. This study aimed to see how cytotoxic&lt;em&gt; L. camara &lt;/em&gt;essential oil was against HeLa carcinoma cells. This research aimed to discover if &lt;em&gt;L. camara&lt;/em&gt; essential oil was cytotoxic to HeLa cancer cells. The GC-MS investigation of an essential oil recognized ten compounds; two main constituents of the oil were Caryophyllene (27.65%) and Germacrene D (23.01%). The essential oil showed cytotoxicity on HeLa cervical cancer cell lines. The cytotoxic effect of oil was determined using MTT, IC&lt;sub&gt;50&lt;/sub&gt; values were 44.86 μg/mL + 0.07&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1498</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Suryati&lt;sup&gt;1&lt;/sup&gt;,*, Dira Hefni&lt;sup&gt;2&lt;/sup&gt;, Fatma Sri Wahyuni&lt;sup&gt;2&lt;/sup&gt;, Dachriyanus&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Universitas Andalas, Kampus Limau Manis, Padang, West Sumatra 25163, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang, West Sumatra 25163, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Surya Dwira</style></author><author><style face="normal" font="default" size="100%">Ariska TP</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Linda Erlina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Cytotoxicity between Ethyl Acetate and Ethanol Extract of White Turmeric (Kaempferia rotunda) Rhizome Extract Against HeLa Cervical Cancer Cell Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti cervical cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaempferia rotunda</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1297-1302</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The aim of this study is to compare between ethanol and ethyl acetate rhizome extract of &lt;em&gt;K.rotunda &lt;/em&gt;against HeLa cervical cancer cell &lt;em&gt;in vitro. &lt;/em&gt;&lt;strong&gt;Material and Methods: &lt;/strong&gt;Methods used in this research are test the chemical compound of extracts using Thin Layer Chromatography (TLC) and phytochemical screening test, also cytotoxicity test using MTT assay. &lt;strong&gt;Result:&lt;/strong&gt; Ethyl acetate extract contains flavonoid, alkaloid, tannin, and triterpenoid, while ethanol extract have flavonoid, triterpenoid, and alkaloid. In addition, ethanol extract has strong cytotoxic activity (IC&lt;sub&gt;50&lt;/sub&gt; = 16,939 μg/ml) while ethyl acetate extract has moderate cytotoxic activity (IC&lt;sub&gt;50&lt;/sub&gt; = 127,9 μg/ml). Each of extracts showed significant results (p ≤ 0,05) although when compared between concentrations there are several concentrations that are not significant and also small coefficient of determinant values caused by various confounding factors. &lt;strong&gt;Conclusion:&lt;/strong&gt; The ethanol extract of &lt;em&gt;K.rotunda &lt;/em&gt;rhizome extract has the higher cytotoxicity activity compared to ethyl acetate extract of&lt;em&gt; K.rotunda&lt;/em&gt; rhizome extract against HeLa cervical cancer cell.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1297</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Surya Dwira&lt;sup&gt;1&lt;/sup&gt;, Ariska TP&lt;sup&gt;2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;1,3,&lt;/sup&gt;*, Norma Nur Azizah&lt;sup&gt;3&lt;/sup&gt;, Linda Erlina&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vijitra Luang-In</style></author><author><style face="normal" font="default" size="100%">Worachot Saengha</style></author><author><style face="normal" font="default" size="100%">Benjaporn Buranrat</style></author><author><style face="normal" font="default" size="100%">Sutisa Nudmamud-Thanoi</style></author><author><style face="normal" font="default" size="100%">Arjan Narbad</style></author><author><style face="normal" font="default" size="100%">Supaporn Pumriw</style></author><author><style face="normal" font="default" size="100%">Wannee Samappito</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity of Lactobacillus plantarum KK518 Isolated from Pak-Sian Dong (Thai Fermented Gynandropsis pentaphylla DC.) Against HepG2, MCF-7 and HeLa Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">HepG2</style></keyword><keyword><style  face="normal" font="default" size="100%">L. plantarum KK518</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7</style></keyword><keyword><style  face="normal" font="default" size="100%">Pak-Sian-Dong</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1050-1057</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pak-Sian Dong is a fermented vegetable product of Thailand prepared from aerial parts of Pak-Sian (&lt;em&gt;Gynandropsis pentaphylla&lt;/em&gt; DC.). Lactobacillus plantarum KK518 was isolated from Pak-Sian Dong and already assessed for its probiotic attributes. &lt;strong&gt;Objective: &lt;/strong&gt;The aim of this work was to determine the untapped cytotoxic effects of&lt;em&gt; L. plantarum&lt;/em&gt; KK518 extract against HepG2 (liver cancer), MCF-7 (breast cancer) and HeLa (cervical cancer) cells. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The bacterial extracts were prepared from whole cultures; containing cells and broths using ethyl acetate as extracting solvent and the dried extracts were redissolved in ethanol before use. Cytotoxic, antiproliferative and antimigratory effects of the bacterial extracts on three types of cancer cells were determined using 3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetra zolium bromide (MTT) assay, clonogenic formation and wound healing assays, respectively. &lt;strong&gt;Results: &lt;/strong&gt;&lt;em&gt;L. plantarum&lt;/em&gt; KK518 extract showed the highest cytotoxicity at 90.88% at 1,000 μg/mL against HeLa cells (IC50 of 371.97 μg/mL) over 48 h of exposure. Anti-colony formation test showed that the bacterial extracts at 600, 800 and 1,000 μg/mL over 48 h led to a complete inhibition of colony formation of HeLa cells; however the highest IC50 of 418.52 μg/mL was found in HepG2 cells suggesting that HepG2 was least affected by bacterial extract. Likewise, HepG2 cells seemed to be most resistant to antimigratory effects as observed by highest relative area of the wound at most time intervals and most extract concentrations. Conclusion: &lt;em&gt;L. plantarum&lt;/em&gt; KK518 offers a potential use as a bio-therapeutic with chemopreventive effects against cervical, breast and liver cancers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1050</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vijitra Luang-In&lt;sup&gt;1,&lt;/sup&gt;*, Worachot Saengha&lt;sup&gt;1&lt;/sup&gt;, Benjaporn Buranrat&lt;sup&gt;2&lt;/sup&gt;, Sutisa Nudmamud-Thanoi&lt;sup&gt;3&lt;/sup&gt;, Arjan Narbad&lt;sup&gt;4&lt;/sup&gt;, Supaporn Pumriw&lt;sup&gt;5&lt;/sup&gt;, Wannee Samappito&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham 44150, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Muang, Maha Sarakham 44000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centre of Excellence in Medical Biotechnology, Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Quadram Institute Bioscience, Norwich Research Park, Colney, Norwich NR4 7UA, UK.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Food Technology, Faculty of Agricultural Technology, Kalasin University, Na Mon District, Kalasin 46230, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Food Technology, Faculty of Technology, Mahasarakham University, Maha Sarakham 44000, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elsayed Omer</style></author><author><style face="normal" font="default" size="100%">Abdelsamed Elshamy</style></author><author><style face="normal" font="default" size="100%">Rihab Taher</style></author><author><style face="normal" font="default" size="100%">Walaa El-Kashak</style></author><author><style face="normal" font="default" size="100%">Joseph Shalom</style></author><author><style face="normal" font="default" size="100%">Alan White</style></author><author><style face="normal" font="default" size="100%">Ian Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cakile maritima Scop. Extracts Inhibit Caco2 and HeLa Human Carcinoma Cell Growth: GC-MS Analysis of an Anti-Proliferative Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Brassicaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">CaCo2</style></keyword><keyword><style  face="normal" font="default" size="100%">European searocket</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">258-266</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Exposure to high levels of antioxidants has been linked to the treatment and prevention of some cancers. Although &lt;em&gt;Cakile maritima&lt;/em&gt; has a high antioxidant capacity, it is yet to be tested for the ability to inhibit the proliferation of cancer cells. &lt;strong&gt;Methods&lt;/strong&gt;: Solvent extracts prepared from &lt;em&gt;C. maritima&lt;/em&gt; plant material were analysed for antioxidant capacity by the DPPH free radical scavenging assay. Anti-proliferative activities against Caco&lt;sub&gt;2&lt;/sub&gt; and HeLa cancer cells were determined by an MTS based cell proliferation assay. Toxicity was determined by the Artemia franciscana bioassay. The most potent anti-proliferative extract (hexane) was further investigated using non-targeted GC-MS headspace analysis. &lt;strong&gt;Results&lt;/strong&gt;: Good DPPH radical scavenging activity was calculated for all &lt;em&gt;C. maritima&lt;/em&gt; extracts. The methanolic and ethyl acetate extracts had particularly strong antioxidant activity (IC&lt;sub&gt;50&lt;/sub&gt; of 4.7 and 3.4 μg/mL respectively). Interestingly, the hexane extract which had the lowest DPPH radical scavenging activity (IC&lt;sub&gt;50&lt;/sub&gt; 13.6 μg/mL), was the most potent inhibitor or Caco&lt;sub&gt;2&lt;/sub&gt; and HeLa carcinoma cell growth, with IC&lt;sub&gt;50&lt;/sub&gt;’s of 12 and 126 μg/mL respectively. The ethyl acetate extract was also a potent inhibitor of proliferation (IC&lt;sub&gt;50&lt;/sub&gt; values of 185 and 468 μg/mL against Caco&lt;sub&gt;2&lt;/sub&gt; and HeLa, respectively). The methanolic extract (IC&lt;sub&gt;50&lt;/sub&gt; values of 2261 and 2046 μg/mL against CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa respectively) displayed only moderate anti-proliferative activity, demonstrating that antioxidant activity did not correspond with anti-proliferative activity. All of the extracts were determined to be nontoxic in the Artemia franciscana bioassay, with LC&lt;sub&gt;50&lt;/sub&gt; values substantially &amp;gt;1000 μg/mL. Non-biased GC-MS headspace analysis of the &lt;em&gt;C. maritima&lt;/em&gt; hexane extract highlighted several interesting compounds that may contribute to the therapeutic bioactivities of the extract. &lt;strong&gt;Conclusion&lt;/strong&gt;: The lack of toxicity and the anti-proliferative activity of the hexane and ethyl acetate &lt;em&gt;C. maritima &lt;/em&gt; extracts against HeLa and Caco&lt;sub&gt;2&lt;/sub&gt; cancer cell lines indicates their potential in the treatment and prevention of some cancers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">258</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Elsayed Omer&lt;sup&gt;1&lt;/sup&gt;, Abdelsamed Elshamy&lt;sup&gt;2&lt;/sup&gt;, Rihab Taher&lt;sup&gt;2&lt;/sup&gt;, Walaa El- Kashak&lt;sup&gt;2&lt;/sup&gt;, Joseph Shalom&lt;sup&gt;3,4&lt;/sup&gt;, Alan White&lt;sup&gt;4&lt;/sup&gt;, Ian Cock&lt;sup&gt;3,4* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal and Aromatic Plants Research , National Research Centre, Giza, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry and Natural Compounds, National Research Centre, Dokki, Giza, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Reece Courtney</style></author><author><style face="normal" font="default" size="100%">J. Sirdaarta</style></author><author><style face="normal" font="default" size="100%">A. White</style></author><author><style face="normal" font="default" size="100%">I. E. Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibition of Caco-2 and HeLa proliferation by Terminalia carpentariae C. T. White and Terminalia grandiflora Benth. extracts: Identification of triterpenoid components</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Australian plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Caco-2</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Combretaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">Native almond</style></keyword><keyword><style  face="normal" font="default" size="100%">Wild peach</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.74</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">441-451</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Background: &lt;em&gt;Terminalia spp&lt;/em&gt;. are characterised by their high antioxidant capacities and many have anticancer activity. This study examines the anti-proliferative activity of &lt;em&gt;T. carpentariae&lt;/em&gt; leaf and &lt;em&gt;T.&lt;/em&gt; &lt;em&gt;grandiflora&lt;/em&gt; leaf, fruit and nut extracts against Caco-2 and HeLa carcinoma proliferation. Materials and Methods: Powdered &lt;em&gt;T. carpentariae&lt;/em&gt; leaf and T.&lt;em&gt; grandiflora&lt;/em&gt; leaf, fruit and nut were extracted and tested for anti-proliferative activity against Caco-2 and HeLa cancer cell lines using colorimetric cell proliferation assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay. The extract with the most potent anti-proliferative activity was examined using GCMS analysis and triterpenoid compounds were identified by comparison with a compound database. Results: &lt;em&gt;T. carpentariae&lt;/em&gt; leaf and T. &lt;em&gt;grandiflora &lt;/em&gt;leaf, fruit and nut extracts displayed potent anti-proliferative activity against Caco-2 and HeLa carcinoma cells. The &lt;em&gt;methanolic T. grandiflora &lt;/em&gt;leaf extract was particularly effective at blocking the proliferation of the colorectal carcinoma Caco-2 (IC50 = 372 &amp;mu;g/mL). The methanol &lt;em&gt;T. carpentariae &lt;/em&gt;and &lt;em&gt;T.&lt;/em&gt; &lt;em&gt;grandiflora&lt;/em&gt; leaf extracts were similarly potent inhibitors of HeLa cervical cancer cell proliferation with IC50 values of 864 and 833 &amp;mu;g/mL respectively. The methanolic T. &lt;em&gt;grandiflora&lt;/em&gt; fruit and nut extracts, as well as all aqueous and ethyl acetate extracts, were moderate to good inhibitors of carcinoma proliferation. In contrast, chloroform and hexane extracts were generally devoid of anti-proliferative activity. The&lt;em&gt; methanolic T.&lt;/em&gt; &lt;em&gt;grandiflora&lt;/em&gt; extracts displayed low toxicity in the Artemia nauplii bioassay. All other extracts were non-toxic. GC-MS analysis of the methanolic T. &lt;em&gt;grandiflora&lt;/em&gt; leaf extract identified 3 lanostane and 2 pentacyclic triterpenoids. Conclusion: The low toxicity and anti-proliferative activity observed with the &lt;em&gt;T. carpentariae &lt;/em&gt;and T. &lt;em&gt;grandiflora&lt;/em&gt; extracts against Caco-2 and HeLa indicate their potential for the prevention and treatment of some cancers.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">441</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Reece Courtney&lt;sup&gt;1,2&lt;/sup&gt;, J. Sirdaarta&lt;sup&gt;1,2&lt;/sup&gt;, A. White&lt;sup&gt;2&lt;/sup&gt;, I. E. Cock&lt;sup&gt;1,2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Alejandra Fernandez</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Therapeutic Properties of Juniperus Communis L.: Antioxidant Capacity, Bacterial growth Inhibition, Anticancer Activity and Toxicity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-bacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant.</style></keyword><keyword><style  face="normal" font="default" size="100%">Artemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Autoimmune inflammatory disease</style></keyword><keyword><style  face="normal" font="default" size="100%">CaCo2</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">Juniper berry</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">273-280</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;J. Communi s&lt;/em&gt;berry is a high antioxidant fruit which is used in several traditional medicinal systems to treat a variety of diseases including rheumatism, arthritis and gout&lt;em&gt;.&lt;/em&gt;This study was undertaken to examine the inhibitory activity of &lt;em&gt;J. communis&lt;/em&gt; berry extracts on the growth of several bacteria associated with autoimmune inflammatory disease, and to test their ability to block CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa cancer cell proliferation. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;J. Communis &lt;/em&gt;solvent extracts were preparedusing solvents of varying polarity. The extracts were investigated by disc diffusion assay for the ability to inhibit the growth of a panel of pathogenic bacteria associated with autoimmune inflammatory diseases. Their MIC values were determined to quantify and compare their efficacies. Inhibitory activity against CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa human carcinoma cell lines was evaluated using an MTS colorimetric cell proliferation assay. Toxicity was determined using the &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay. &lt;strong&gt;Results: &lt;/strong&gt;The methanol, water and ethyl acetate &lt;em&gt;J. communis&lt;/em&gt; berry extracts displayed moderate to potent growth inhibitory activity against bacterial triggers of rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis. The methanol and water extracts displayed the broadest specificity, inhibiting the growth of all bacteria tested. The ethyl acetate extract also displayed antibacterial activity, inhibiting the growth of 9 of the 13 bacterial strains (69%). The ethyl acetate extract displayed the greatest potency, with MIC values substantially below 2000 &amp;micro;g/mL for all bacteria which it inhibited. It was most effective at inhibiting the growth of &lt;em&gt;P. mirabilis&lt;/em&gt;, &lt;em&gt;P. vulgaris&lt;/em&gt; and &lt;em&gt;S. aureus&lt;/em&gt;, each with MIC&amp;rsquo;s &amp;le; 500 &amp;micro;g/mL. The methanol and water extracts also proved effective at blocking the proliferation of the colorectal cancer cell line CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa cervical cancer cell growth, with IC&lt;sub&gt;50&lt;/sub&gt; values in the 1300-2500 &amp;micro;g/mL range. All extracts were non-toxic in the &lt;em&gt;Artemia&lt;/em&gt; nauplii bioassay. &lt;strong&gt;Conclusion: &lt;/strong&gt;The lack of toxicity of the &lt;em&gt;J. Communis &lt;/em&gt;berry extracts and their potent growth inhibitory bioactivity against bacteria and HeLa and CaCo&lt;sub&gt;2&lt;/sub&gt; carcinoma cells indicates their potential in the treatment and prevention of selected autoimmune inflammatory diseases and some cancers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Orginal Article</style></work-type><section><style face="normal" font="default" size="100%">273</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Alejandra Fernandez&lt;sup&gt;1&lt;/sup&gt; and Ian Edwin Cock&lt;sup&gt;1,2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
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