<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prajna R H</style></author><author><style face="normal" font="default" size="100%">Shivananda Nayak</style></author><author><style face="normal" font="default" size="100%">Priya V</style></author><author><style face="normal" font="default" size="100%">Shruthi Rai P</style></author><author><style face="normal" font="default" size="100%">Shivaraja shankara Y M</style></author><author><style face="normal" font="default" size="100%">Prashanthkumar Goudappala</style></author><author><style face="normal" font="default" size="100%">Dinesh PV</style></author><author><style face="normal" font="default" size="100%">Namratha KG</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The role of TNF-Alpha, IL-6, Adiponectin, and Leptin in Inflammation and Metabolic Dysregulation in Type 2 Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adiponectin</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Leptin</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolic Dysregulation</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-Alpha</style></keyword><keyword><style  face="normal" font="default" size="100%">Type 2 diabetes mellitus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">699-702</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Type 2 Diabetes Mellitus (T2DM) is characterized by chronic inflammation and metabolic dysregulation. The present study investigates the role of inflammatory markers, including TNF-alpha and IL-6, and metabolic hormones such as adiponectin and leptin, in individuals with T2DM. &lt;strong&gt;Methods:&lt;/strong&gt; A total of 147 participants diagnosed with T2DM were included in the study. Clinical and biochemical parameters, including fasting blood sugar (FBS), glycated hemoglobin (HbA1C), adiponectin, leptin, TNF-alpha, and IL-6, were measured. Descriptive statistics and correlation analysis were performed to determine associations between inflammatory markers and metabolic dysregulation.&lt;strong&gt; Results: &lt;/strong&gt;The mean age of participants was &lt;strong&gt;42.63 ± 6.38 &lt;/strong&gt;years, and the average BMI was &lt;strong&gt;28.38 ± 2.25 kg/m²&lt;/strong&gt;. FBS and HbA1C levels were &lt;strong&gt;175.72 ± 61.61 mg/dL&lt;/strong&gt; and &lt;strong&gt;7.26 ± 0.94%,&lt;/strong&gt; respectively. The mean adiponectin and leptin levels were &lt;strong&gt;4.71 ± 1.75 μg/mL&lt;/strong&gt; and &lt;strong&gt;20.58 ± 5.19 ng/mL&lt;/strong&gt;, respectively. TNF-alpha and IL-6 levels averaged &lt;strong&gt;132.00 ± 9.45 pg/mL&lt;/strong&gt; and &lt;strong&gt;33.52 ± 14.55 pg/mL&lt;/strong&gt;, respectively. Correlation analysis indicated an inverse relationship between adiponectin and BMI, while leptin was positively correlated with BMI and insulin levels. Elevated TNFalpha and IL-6 levels were associated with increased HbA1C and fasting blood glucose. &lt;strong&gt;Conclusion: &lt;/strong&gt;This study highlights the significant role of inflammatory markers in metabolic dysregulation among T2DM patients. Elevated TNF-alpha and IL-6 levels reinforce the link between chronic inflammation and impaired glucose metabolism. These findings underscore the need for anti-inflammatory strategies in diabetes management.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">699</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prajna R H&lt;sup&gt;1,2&lt;/sup&gt;, Shivananda Nayak&lt;sup&gt;3&lt;/sup&gt;, Priya V&lt;sup&gt;4*&lt;/sup&gt;, Shruthi Rai P&lt;sup&gt;5&lt;/sup&gt;, Shivaraja shankara Y M&lt;sup&gt;6&lt;/sup&gt;, Prashanthkumar Goudappala&lt;sup&gt;7&lt;/sup&gt;, Dinesh PV&lt;sup&gt;8&lt;/sup&gt;, Namratha KG&lt;sup&gt;9&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research scholar, SaveethaResearch Center, Saveetha Institute of Medical and Technical Sciences(SIMATS), Chennai, INDIA,600077&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Biochemistry, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor, Department of Biochemistry, Subbaiah Institute of Medical Science, Shivamogga, INDIA,577222&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Center of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University Chennai, INDIA,600077&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Biochemistry, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Biochemistry, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Associate Professor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, INDIA ,572107&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Professor, Department of Community medicine, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Professor, Department of Microbiology, KVG Medical College and Hospital,Sullia , INDIA, 574327.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wardah Rahmatul Islamiyah</style></author><author><style face="normal" font="default" size="100%">Nasronudin</style></author><author><style face="normal" font="default" size="100%">Abdulloh Machin</style></author><author><style face="normal" font="default" size="100%">Iin Ernawati</style></author><author><style face="normal" font="default" size="100%">Yunita Dwi Tanti</style></author><author><style face="normal" font="default" size="100%">Nur Jaya</style></author><author><style face="normal" font="default" size="100%">Farah Medina</style></author><author><style face="normal" font="default" size="100%">Fathia Faza Rahmadanita</style></author><author><style face="normal" font="default" size="100%">Paulus Sugianto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of The Effect of Leptin, AMPK, Adiponectin, and NPY Markers on Changes in Body Weight of Childhood Epileptic Using Valproic Acid Monotherapy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adiponectin</style></keyword><keyword><style  face="normal" font="default" size="100%">AMPK</style></keyword><keyword><style  face="normal" font="default" size="100%">Childhood.</style></keyword><keyword><style  face="normal" font="default" size="100%">Epilepsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Leptin</style></keyword><keyword><style  face="normal" font="default" size="100%">NPY</style></keyword><keyword><style  face="normal" font="default" size="100%">Valproic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Weight gain</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">150-153</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Epilepsy is a neurological disorder that occurs due to abnormal neurons in the brain and an imbalance between excitation and inhibition in the central nervous system. The first line of OAE in children is VPA (Valproate Acid). However, long-term use can cause weight gain with a frequency of 10-70%. The underlying mechanism of weight gain in patients remains unclear. &lt;strong&gt;Purpose: &lt;/strong&gt;This study aimed to analyze the relationship between levels of biomarkers AMPK, NPY, Leptin, and Adiponectin on changes in body weight in patients with epileptic seizures using VPA monotherapy. Method: This study is an observational cohort design. Data collection in April-June 2019. Inclusion criteria were children aged 2-10 years who used VPA requirement less than two years, not taking any drugs that affect body weight, not diagnose systemic lupus, nephrotic syndrome, and diabetes mellitus. Bodyweight and all biomarkers measurement on subjects who came to the clinic at the time of study and at least after one month of taking VPA. A total of 17 subjects participated in this study.&lt;strong&gt; Result: &lt;/strong&gt;The results of the statistical multivariate analysis test of VPA dosage on changes in body weight and biomarker levels found that Leptin, AMPK, Adiponectin did not significantly increase in body weight (p&amp;gt;0.05), but NPY significant increase in body weight (p&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; NPY is the most potent for appetite enhancing, preferential effect on carbohydrate intake, weight regulation, energy storage, and expenditure. Increase production of NPY, there is an increase in energy intake and then increases fat storage and body weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Wardah Rahmatul Islamiyah1&lt;sup&gt;,2&lt;/sup&gt;, Nasronudin&lt;sup&gt;3,4,*&lt;/sup&gt;, Abdulloh Machin&lt;sup&gt;2&lt;/sup&gt;, Iin Ernawati&lt;sup&gt;5&lt;/sup&gt;, Yunita Dwi Tanti&lt;sup&gt;6&lt;/sup&gt;, Nur Jaya&lt;sup&gt;7&lt;/sup&gt;, Farah Medina&lt;sup&gt;8&lt;/sup&gt;, Fathia Faza Rahmadanita&lt;sup&gt;9&lt;/sup&gt;, Paulus Sugianto&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universitas Airlangga Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Akademi Farmasi Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Ngudi Waluyo Hospital Wlingi Blitar, INDONESIA. 7Budi Agung Hospital, Palu, INDONESIA. 8Oncology Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Faculty of Medicine and Health Science Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESIA.&lt;/p&gt;
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