<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kasturi Bhattacharjee</style></author><author><style face="normal" font="default" size="100%">Moumita Nath</style></author><author><style face="normal" font="default" size="100%">Yashmin Choudhury</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Berberine Mitigates Betel-Nut Induced Hepatocarcinogenesis, Enhances Chemosensitivity to Cisplatin and Reduces Cisplatin- Induced Nephrotoxicity in Mice Exposed to an Aqueous Extract of Betel Nut</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">AEBN</style></keyword><keyword><style  face="normal" font="default" size="100%">Berberine</style></keyword><keyword><style  face="normal" font="default" size="100%">Betel-Nut</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Cisplatin</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1021-1028</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; There is a considerable correlation between the use of betel-nut (BN) as a chewing substance and the development of various malignancies. Objective: The bioactive phytocompound berberine was tested as monotherapy or in combination with cisplatin to reduce BN-induced carcinogenesis in mice. We also examined how berberine affected cisplatin-induced toxicity. &lt;strong&gt;Methods:&lt;/strong&gt; Swiss Albino mice were exposed to aqueous extract of betel-nut (AEBN) at a dose of 2 mg ml-1 in drinking water, for 16 weeks. Following this, the mice were given a combination of AEBN and berberine (10 mg kg&lt;sup&gt;-1&lt;/sup&gt;) for 8 weeks. Control mice were given drinking water without AEBN for 24 weeks. For the combination treatment, mice that had been exposed to AEBN (2 mg ml&lt;sup&gt;-1&lt;/sup&gt;) for 16 weeks were given AEBN+sodiumchloride+cisplatin (5 mg kg&lt;sup&gt;-1&lt;/sup&gt;) +berberine (10 mg kg&lt;sup&gt;-1&lt;/sup&gt;) for 2 weeks. Histopathology, oxidative stress, proliferation, apoptosis, oncogenic and tumor suppressor proteins, hepatotoxicity, and nephrotoxicity were assessed in tissues retrieved at treatment endpoints. &lt;strong&gt;Results: &lt;/strong&gt;Berberine monotherapy reduced tissue dysplasia, liver nodulation, oxidative stress, proliferation (Ki-67 and Cyclin D1) markers, Akt/mTOR signaling, and pP53 (Ser-15) levels and apoptosis in AEBN-treated mice to levels comparable to cisplatin alone. Berberine with cisplatin decreased nephrotoxicity, fur shedding, and cancer phenotype more than cisplatin alone. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study results imparted a new therapeutic approach in developing more effective and less harmful cancer treatments.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1021</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kasturi Bhattacharjee, Moumita Nath, Yashmin Choudhury*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biotechnology, Assam University, Silchar-788011, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herin Setianingsih</style></author><author><style face="normal" font="default" size="100%">Nasywa Zahra Sajida Tsuroyya</style></author><author><style face="normal" font="default" size="100%">Prawesty Diah Utami</style></author><author><style face="normal" font="default" size="100%">Riami</style></author><author><style face="normal" font="default" size="100%">Nanang Wiyono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Visual Mapping and Future Direction of Marine Products Supplementary and Chemotherapy in The Treatment of Breast Cancer. A Bibliometric</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Bibliometric</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Marine products</style></keyword><keyword><style  face="normal" font="default" size="100%">Visual mapping</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1379-1388</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Marine products have gained attention for their potential benefits in the treatment of breast cancer, offering an alternative or supplementary approach to traditional therapies. While they are not intended to replace established medical treatments like chemotherapy or surgery, marine natural products have shown promise in providing symptom relief, enhancing the quality of life, and potentially improving treatment success for breast cancer patients. Studies have explored the use of marine products in conjunction with chemotherapy for their palliative care benefits and as adjuvants to conventional therapies. Marinederived compounds have been investigated for their anticancer properties, including apoptosis induction, anti-proliferative effects, and modulation of signaling pathways involved in breast cancer progression. These natural products offer a complementary avenue for managing breast cancer, potentially enhancing treatment outcomes, and addressing therapeutic challenges. The utilization of marine products in breast cancer therapy dates back to ancient times when various cultures recognized the therapeutic benefits of plants, herbs, and marine resources. The purpose of this study is to visually map and guide future research on supplementary marine products and chemotherapy in breast cancer based on bibliometric analysis&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1379</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herin Setianingsih&lt;sup&gt;1*&lt;/sup&gt;, Nasywa Zahra Sajida Tsuroyya&lt;sup&gt;1&lt;/sup&gt;, Prawesty Diah Utami&lt;sup&gt;1&lt;/sup&gt;, Riami&lt;sup&gt;1&lt;/sup&gt;, Nanang Wiyono&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siti Nurul Najiha Othman</style></author><author><style face="normal" font="default" size="100%">Pei Teng Lum</style></author><author><style face="normal" font="default" size="100%">Siew Hua Gan</style></author><author><style face="normal" font="default" size="100%">Shankar Mani</style></author><author><style face="normal" font="default" size="100%">Mahendran Sekar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Effect of Natural Products against Chemotherapy-Induced Cardiotoxicity: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Cardioprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Cardiotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1180-1189</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cancer is one of the diseases with high mortality rate recorded each year across the world. Its mainstay treatment is chemotherapy although they are largely toxic, causing severe adverse reactions including cardiotoxicity, nephrotoxicity and genotoxicity. Cardiotoxicity is unique to certain chemotherapeutic agents and occur via several mechanisms. It has been hypothesized that co-administration of natural products which may be cardioprotectant, together with chemotherapy can alleviate cardiotoxicity-induced by chemotherapy. &lt;strong&gt;Objectives:&lt;/strong&gt; This review aimed to provide a brief information about the protective effect of natural products against chemotherapy-induced cardiotoxicity &lt;strong&gt;Methods:&lt;/strong&gt; To complete this review, relevant literatures were searched from several scientific databases including Google, Google Scholar, Scopus, Web of Science and Pubmed. &lt;strong&gt;Results: &lt;/strong&gt;In this paper, we have reviewed ten natural products (curcumin, mangiferin, naringenin, quercetin, 6-gingerol, lycopene, resveratrol, apigenin, proanthocyanidins and indole-3-carbinol), which have major influences in attenuating chemotherapy-drug induced cardiotoxicity. Apart from the cardioprotective effects, they tend to confer some synergistic effects with chemotherapeutic agents and therefore have the potential to be used as an adjunct. &lt;strong&gt;Conclusion:&lt;/strong&gt; Though a panel of natural products demonstrate protective effects against cardiotoxicity in cells and animal models, their therapeutic potentials for clinical needs further investigation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1180</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siti Nurul Najiha Othman&lt;sup&gt;1&lt;/sup&gt;, Pei Teng Lum&lt;sup&gt;1&lt;/sup&gt;, Siew Hua Gan&lt;sup&gt;2&lt;/sup&gt;, Shankar Mani&lt;sup&gt;3&lt;/sup&gt;, Mahendran Sekar&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh - 30450, Perak, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Selangor Darul Ehsan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Nagamangala, Mandya - 571418, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Reece Courtney</style></author><author><style face="normal" font="default" size="100%">J. Sirdaarta</style></author><author><style face="normal" font="default" size="100%">A. White</style></author><author><style face="normal" font="default" size="100%">I. E. Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibition of Caco-2 and HeLa proliferation by Terminalia carpentariae C. T. White and Terminalia grandiflora Benth. extracts: Identification of triterpenoid components</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Australian plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Caco-2</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Combretaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">Native almond</style></keyword><keyword><style  face="normal" font="default" size="100%">Wild peach</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.74</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">441-451</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Background: &lt;em&gt;Terminalia spp&lt;/em&gt;. are characterised by their high antioxidant capacities and many have anticancer activity. This study examines the anti-proliferative activity of &lt;em&gt;T. carpentariae&lt;/em&gt; leaf and &lt;em&gt;T.&lt;/em&gt; &lt;em&gt;grandiflora&lt;/em&gt; leaf, fruit and nut extracts against Caco-2 and HeLa carcinoma proliferation. Materials and Methods: Powdered &lt;em&gt;T. carpentariae&lt;/em&gt; leaf and T.&lt;em&gt; grandiflora&lt;/em&gt; leaf, fruit and nut were extracted and tested for anti-proliferative activity against Caco-2 and HeLa cancer cell lines using colorimetric cell proliferation assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay. The extract with the most potent anti-proliferative activity was examined using GCMS analysis and triterpenoid compounds were identified by comparison with a compound database. Results: &lt;em&gt;T. carpentariae&lt;/em&gt; leaf and T. &lt;em&gt;grandiflora &lt;/em&gt;leaf, fruit and nut extracts displayed potent anti-proliferative activity against Caco-2 and HeLa carcinoma cells. The &lt;em&gt;methanolic T. grandiflora &lt;/em&gt;leaf extract was particularly effective at blocking the proliferation of the colorectal carcinoma Caco-2 (IC50 = 372 &amp;mu;g/mL). The methanol &lt;em&gt;T. carpentariae &lt;/em&gt;and &lt;em&gt;T.&lt;/em&gt; &lt;em&gt;grandiflora&lt;/em&gt; leaf extracts were similarly potent inhibitors of HeLa cervical cancer cell proliferation with IC50 values of 864 and 833 &amp;mu;g/mL respectively. The methanolic T. &lt;em&gt;grandiflora&lt;/em&gt; fruit and nut extracts, as well as all aqueous and ethyl acetate extracts, were moderate to good inhibitors of carcinoma proliferation. In contrast, chloroform and hexane extracts were generally devoid of anti-proliferative activity. The&lt;em&gt; methanolic T.&lt;/em&gt; &lt;em&gt;grandiflora&lt;/em&gt; extracts displayed low toxicity in the Artemia nauplii bioassay. All other extracts were non-toxic. GC-MS analysis of the methanolic T. &lt;em&gt;grandiflora&lt;/em&gt; leaf extract identified 3 lanostane and 2 pentacyclic triterpenoids. Conclusion: The low toxicity and anti-proliferative activity observed with the &lt;em&gt;T. carpentariae &lt;/em&gt;and T. &lt;em&gt;grandiflora&lt;/em&gt; extracts against Caco-2 and HeLa indicate their potential for the prevention and treatment of some cancers.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">441</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Reece Courtney&lt;sup&gt;1,2&lt;/sup&gt;, J. Sirdaarta&lt;sup&gt;1,2&lt;/sup&gt;, A. White&lt;sup&gt;2&lt;/sup&gt;, I. E. Cock&lt;sup&gt;1,2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sonika Jain</style></author><author><style face="normal" font="default" size="100%">Jaya Dwivedi</style></author><author><style face="normal" font="default" size="100%">Pankaj Kumar Jain</style></author><author><style face="normal" font="default" size="100%">Swaha Satpathy</style></author><author><style face="normal" font="default" size="100%">Arjun Patra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Medicinal Plants for Treatment of Cancer: A Brief Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Allopathic Drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer Cell Lines.</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal Plants.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">87-102</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Cancer is actually a group of many related diseases that all have to do with cells. Cancer cells are characterized by unregulated growth, as well as insufficient and inappropriate vascular supply. Moreover, a core of cells was subjected to micro environmental stress conditions, and has decreased apoptotic potential through genetic alterations, thereby resulting in resistance to apoptosis. Cancer is one of the major causes of death worldwide where the number of cancer patients is in continuous rise. Cancer is a major public problem whose estimated worldwide new incidence is about 6 million cases per year. It is the second major cause of deaths after cardiovascular diseases. Chemotherapy remains the principal mode of treatment for various cancers. A number of synthetic anticancer drugs are available in practice, but the side effects and the drug interactions are major drawbacks in its clinical utility. Most of the currently used chemotherapy drugs for cancers are known to develop resistance, exhibit non-selective toxicity against normal cells and restrict by dose-limiting side effects. Hence, cancer treatment and development of drugs for this disease remains a major clinical challenge. On the other hand, plants are an exceptionally viable source of biologically active natural products which may serve as commercially significant entities in themselves or which may provide lead structures for the development of modified derivatives possessing enhanced activity and/or reduced toxicity in traeatment of cancer. Herbal medicines are now attracting attention as potential sources of anticancer agents and are widely used due to availability of the materials, affordability, relatively cheap and little or no side effects, wide applicability and therapeutic efficacy which in turn has accelerated the scientific research. For these reasons, World Health Organization (WHO) supports the use of traditional medicines which are efficacious and non toxic. In this review we have summarized few plants having anticancer activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">87</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sonika Jain,&lt;sup&gt;1&lt;/sup&gt; Jaya Dwivedi&lt;sup&gt;1&lt;/sup&gt;, Pankaj Kumar Jain&lt;sup&gt;2&lt;/sup&gt;, Swaha Satpathy&lt;sup&gt;3&lt;/sup&gt; and Arjun Patra&lt;sup&gt;3*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Banasthali Vidyapith, Rajasthan, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Banasthali Vidyapith, Rajasthan, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.), INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&amp;nbsp;&lt;/p&gt;
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