<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Etty Hary Kusumastuti</style></author><author><style face="normal" font="default" size="100%">Priangga Adi Wiratama</style></author><author><style face="normal" font="default" size="100%">Grace Ariani</style></author><author><style face="normal" font="default" size="100%">Stephanie Natasha Djuanda</style></author><author><style face="normal" font="default" size="100%">Alphania Rahniayu</style></author><author><style face="normal" font="default" size="100%">Nila Kurniasari</style></author><author><style face="normal" font="default" size="100%">Dyah Fauziah</style></author><author><style face="normal" font="default" size="100%">Anny Setijo Rahaju</style></author><author><style face="normal" font="default" size="100%">Isnin Anang Marhana</style></author><author><style face="normal" font="default" size="100%">Alfian Nur Rosyid</style></author><author><style face="normal" font="default" size="100%">Dwi Wahyu</style></author><author><style face="normal" font="default" size="100%">Gilang Muhammad Setyo Nugroho</style></author><author><style face="normal" font="default" size="100%">Adhitri Anggoro</style></author><author><style face="normal" font="default" size="100%">I Komang Rusgi Yandi</style></author><author><style face="normal" font="default" size="100%">Bambang Pujo Semedi</style></author><author><style face="normal" font="default" size="100%">Jilientasia Godrace Lilihata</style></author><author><style face="normal" font="default" size="100%">Ummi Maimunah</style></author><author><style face="normal" font="default" size="100%">Supriadi</style></author><author><style face="normal" font="default" size="100%">Achmad Lefi</style></author><author><style face="normal" font="default" size="100%">Lalu Galih Pratama Rinjani</style></author><author><style face="normal" font="default" size="100%">Edi Suyanto</style></author><author><style face="normal" font="default" size="100%">Ricardo Ardian Nugraha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Differences in interleukin-6 and interleukin-17 expression in covid-19 post-mortem lung tissue biopsy compared with noncovid- 19</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biopsy</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-17</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Post mortem lung tissue.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">887-892</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients. Methods: This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure. &lt;strong&gt;Result: &lt;/strong&gt;There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p &amp;lt; 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p &amp;lt; 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p &amp;lt; 0.05).&lt;strong&gt; Conclusion:&lt;/strong&gt; There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">887</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Etty Hary Kusumastuti&lt;sup&gt;1,*&lt;/sup&gt;, Priangga Adi Wiratama&lt;sup&gt;1&lt;/sup&gt;, Grace Ariani&lt;sup&gt;1&lt;/sup&gt;, Stephanie Natasha Djuanda&lt;sup&gt;1&lt;/sup&gt;, Alphania Rahniayu&lt;sup&gt;1&lt;/sup&gt;, Nila Kurniasari&lt;sup&gt;1&lt;/sup&gt;, Dyah Fauziah1, Anny Setijo Rahaju&lt;sup&gt;1&lt;/sup&gt;, Isnin Anang Marhana&lt;sup&gt;2&lt;/sup&gt;, Alfian Nur Rosyid&lt;sup&gt;2&lt;/sup&gt;, Dwi Wahyu&lt;sup&gt;2&lt;/sup&gt;, Gilang Muhammad Setyo Nugroho&lt;sup&gt;2&lt;/sup&gt;, Adhitri Anggoro&lt;sup&gt;2&lt;/sup&gt;, I Komang Rusgi Yandi&lt;sup&gt;2&lt;/sup&gt; Bambang Pujo Semedi&lt;sup&gt;3&lt;/sup&gt;, Jilientasia Godrace Lilihata&lt;sup&gt;3&lt;/sup&gt;, Ummi Maimunah&lt;sup&gt;4&lt;/sup&gt;, Supriadi&lt;sup&gt;4&lt;/sup&gt;, Achmad Lefi&lt;sup&gt;5&lt;/sup&gt;, Lalu Galih Pratama Rinjani&lt;sup&gt;5&lt;/sup&gt;, Edi Suyanto&lt;sup&gt;6&lt;/sup&gt;, Ricardo Ardian Nugraha&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anesthesiology and Reanimation, Faculty of Medicine, Universitas Airlangga University – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Forensics and Medicolegal Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
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