<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory Effect of Carallia Brachiata Extract Through Regulation of Adipogenesis Pathways in 3T3-L1 Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3T3-L1 adipocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Adipogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Carallia brachiata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">655-660</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pharmacological effects of &lt;em&gt;Carallia brachiata Merr&lt;/em&gt;. has been reported to show antioxidant effects against the development of diabetes. However, the mechanism underlying antiadipogenic activity have not been investigated. &lt;strong&gt;Objective:&lt;/strong&gt; Effect of&lt;em&gt; Carallia brachiata&lt;/em&gt; ethanolic extract was determined on inhibition of adipogenesis in 3T3-L1 adipocytes.&lt;strong&gt; Materials and Methods&lt;/strong&gt;: Adipose tissue development was performed in preadipocyte 3T3-L1 cells culture. &lt;em&gt;Carallia brachiata&lt;/em&gt; leaf (CL) and stem (CS) part were selected for measuring cytotoxicity, accumulation of lipids, and genes involved in adipogenic differentiation. &lt;strong&gt;Results:&lt;/strong&gt; During the adipogenic differentiation, CS down-regulated gene expression of adipogenic transcription factors (PPARγ, C/EBPα, aP2, FAS, LPL and SREBP1c). However, CL only suppressed SREBP1c and aP2 genes. The accumulation of lipids was suppressed by CS, but CL could not show this effect. &lt;strong&gt;Conclusion&lt;/strong&gt;: Our findings suggest that ethanol extract of &lt;em&gt;Carallia brachiata&lt;/em&gt; stem has a better anti-adipogenesis effect than the leaf part by suppressing adipogenesis-related gene expression. Moreover, inhibition of lipid storage could be decreased insulin resistance risk.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">655</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;
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