<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Rauza Sukma Rita</style></author><author><style face="normal" font="default" size="100%">Dachriyanus</style></author><author><style face="normal" font="default" size="100%">Yohanes Alen</style></author><author><style face="normal" font="default" size="100%">Salman Umar</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunostimulating Study of Active Agent Fraction from Sungkai (Peronema canescens Jack.) Leaf from SARS-COV-2 Virus Antigen Exposure to NK and CD8+T Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CD8+T Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">NK Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Peronema canescens Jack.</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">344-351</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sungkai (Peronema canescens Jack.) plant had been used as an immune system enhancer. &lt;strong&gt;Aim&lt;/strong&gt;: In this study, the effect of Sungkai leaf extracts from 4 different fractions, namely n-hexane, ethyl acetate, butanol and residual water with 3 variations in doses of 1,10 and 100 mg/kg bw on the activity of NK and CD8+T cells in male white mice that have been exposed to SARS-Cov-2 virus antigen was investigated.&lt;strong&gt; Methods:&lt;/strong&gt; The experimental animals used were 60 animals divided into 12 groups with 14 days of treatment which had previously been induced with SARS-Cov-2 virus antigen (Moderna) and given with Sungkai leaf extracts for 14 days and evaluated on day 15. The evaluation results of NK cells concentrations sequentially were 2.96; 4.66; 5.38; 5.43; 4.05; 2.89; 3.56; 4.21; 2.88; 1.99; 2.07; 4.40; 3.21; 3.40; and 6.93 ng/ml. On the other hand, the evaluation results of CD8+T cells concentrations sequentially were 27.47; 28.96; 29.19; 27.90; 21.85; 25.79; 27.98; 23.50; 23.39; 26.56; 22.62; 25.19; 23,55; 26,75; and 29,69 ng/ml. One-way ANOVA and Duncan test were used for the data analysis. &lt;strong&gt;Results: &lt;/strong&gt;The results showed significant increase of concentration (p&amp;lt;0.05) towards concentration of NK cells in the butanol fraction at a dose of 1 mg/kg BW and CD8+T cells in the residual water fraction at a dose of 100 mg/kg BW. &lt;strong&gt;Conclusion&lt;/strong&gt;: It can be concluded that fraction from sungkai (&lt;em&gt;Peronema canescens&lt;/em&gt; Jack.) at doses of 1,10 and 100 mg/kg bw shows immunostimulatory activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">13</style></accession-num><section><style face="normal" font="default" size="100%">344</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dwisari Dillasamola&lt;sup&gt;1,*&lt;/sup&gt;, Fatma Sri Wahyuni&lt;sup&gt;1&lt;/sup&gt;, Rauza Sukma Rita&lt;sup&gt;2&lt;/sup&gt;, Dachriyanus&lt;sup&gt;1&lt;/sup&gt;, Yohanes Alen&lt;sup&gt;1&lt;/sup&gt;, Salman Umar&lt;sup&gt;1&lt;/sup&gt;, Yufri Aldi&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy Universitas, Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine Universitas, Andalas, INDONESIA.&lt;/p&gt;
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