<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pujiati Pujiati</style></author><author><style face="normal" font="default" size="100%">Soetrisno</style></author><author><style face="normal" font="default" size="100%">Dono Indarto</style></author><author><style face="normal" font="default" size="100%">Reviono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Vivo Studies of Combined Probiotics on IFN-γ, Ig-E and Bronchial Muscular Layer of Rats with Allergic Asthma</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asthma</style></keyword><keyword><style  face="normal" font="default" size="100%">Bronchus histopatology</style></keyword><keyword><style  face="normal" font="default" size="100%">IFN-γ</style></keyword><keyword><style  face="normal" font="default" size="100%">Ig-E</style></keyword><keyword><style  face="normal" font="default" size="100%">Lactobacillus brevis</style></keyword><keyword><style  face="normal" font="default" size="100%">Leuconostoc mesenteriodes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">598-603</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Leuconostoc mesenteriodes&lt;/em&gt; and &lt;em&gt;Lactobacillus brevis &lt;/em&gt;are being used as probiotic to improve the immune system. The effect of probiotic containing combination of the 2 bacteria on enhancing innate and adaptive immune responses is not fully understood.&lt;strong&gt; Objective:&lt;/strong&gt; This was conducted to analyse the effect of probiotic containing in single or combination content of L. &lt;em&gt;mesenteriodes &lt;/em&gt;(Lm) and L.&lt;em&gt; brevis&lt;/em&gt; (Lb) on IFN-γ concentration, Ig-E concentration, and histopathology of bronchial muscular layer of ovalbumininduced allergic asthma. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; A total of 40 male Sprague Dawley rats (6–8 weeks, 200-300 g) were randomly divided into 5 groups: NC (non-induced control group); NgC (OVA-induced control group), Lm (OVA +probiotics containing L. &lt;em&gt;mesenteriodes&lt;/em&gt;), Lb (OVA + probiotics containing L. brevis), and Lm + Lb (OVA+probiotics containing combination of L. &lt;em&gt;mesenteriodes &lt;/em&gt;and L&lt;em&gt;. brevis&lt;/em&gt;). On 64-day, concentration of IFN-γ and Ig-E in serum were measured. Histology of bronchus was performed.&lt;strong&gt; Results: &lt;/strong&gt;IFN-γ concentration, Ig-E The administration of single or combined probiotics increased IFN-γ (p&amp;lt;0.001), yet decreased IgE (p&amp;lt;0.001) of all treatment groups, but only a combination of both probiotics reduced the thickness of the bronchial epithelium.&lt;strong&gt; Conclusion: &lt;/strong&gt;The combination of Lm and Lb single or combined probiotics improve systemic and local anti-inflammation effects and ameliorate airway remodelling in the ovalbumin-induced chronic asthma rat model.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">17</style></accession-num><section><style face="normal" font="default" size="100%">598</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pujiati Pujiati&lt;sup&gt;1,2,*&lt;/sup&gt;, Soetrisno&lt;sup&gt;3&lt;/sup&gt;, Dono Indarto&lt;sup&gt;4&lt;/sup&gt;, Reviono&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Student of Medical Sciences, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pediatrics, Kindly change to “Universitas Islam Sultan Agung, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Obstetrics and Gynecology, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Physiology, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pulmonogy and Respirology, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;
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