<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Atini Solawati</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Heri Setiawan</style></author><author><style face="normal" font="default" size="100%">Raysa Yunda Pratiwi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Subchronic Toxicity Studies of a Combined Andrographis paniculata (Burm.f.) Nees, Syzygium cumini (L) Skeels, and Caesalpinia sappan L Extract in Sprague-Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andrographis paniculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Caesalpinia sappan</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats.</style></keyword><keyword><style  face="normal" font="default" size="100%">Subchronic yoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium cumini</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">531-535</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Andrographis paniculata, Syzygium cumini and Caesalpinia sappan&lt;/em&gt; (ASC) are plants that are widely used as traditional medicines in treating diabetes. The acute toxicity test results of the combination of these three plants were safe up to 5000 mg/Kg BB. &lt;strong&gt;Objectives: &lt;/strong&gt;To evaluate subchronic toxicity of a combined ASC extract. &lt;strong&gt;Methods: &lt;/strong&gt;Male and female &lt;em&gt;Sprague Dawley &lt;/em&gt;rats were acclimatized for 14 days and then fed a normal diet with ASC extract at doses of 150, 575 and 1000 mg/kg BW daily for 135 days. At the end of the study, the rats were sacrificed and then blood, heart, pulmonary, liver, kidneys, spleen and pancreas were collected. Result: The results showed no abnormality in the experimental group compared with the control group. All values of other parameters assessed remained within the normal range.&lt;strong&gt; Conclusions:&lt;/strong&gt; The combination of ASC extract given orally for 135 days to male and female rats did not show any subchronic toxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">07</style></accession-num><section><style face="normal" font="default" size="100%">531</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Atini Solawati, Berna Elya*, Heri Setiawan, Raysa Yunda Pratiwi&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;
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