<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Franelyne P. Casuga</style></author><author><style face="normal" font="default" size="100%">Agnes L. Castillo</style></author><author><style face="normal" font="default" size="100%">Mary Jho-Anne T. Corpuz</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bioactive Compounds and Cytotoxicity of Ethyl Acetate Extract From Broussonetia luzonica (Moraceae) Blanco Leaves against Hepatocellular Carcinoma (Hepg2) Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Endemic</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">497-501</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Broussonetia luzonica&lt;/em&gt; (Moraceae) Blanco is an edible and endemic plant in the Philippines. Other species of the plant are used traditionally in Chinese medicine to treat impotency and eye disorders and was proven to have anticancer potential. To date, there are no published scientific evidences yet to prove the cytotoxicity against hepatocellular carcinoma cell lines (HepG2) of &lt;em&gt;B. luzonica&lt;/em&gt;. Furthermore, the bioactive compounds of the ethyl acetate leaf extract were determined. &lt;strong&gt;Methods:&lt;/strong&gt; Bioactive compounds were determined using Gas Chromatography-Mass Spectrometry (GC-MS). To determine the IC&lt;sub&gt;50&lt;/sub&gt;, the percentage Hepg2 Cell inhibition of the extract at 200 &amp;mu;g/mL, 100 &amp;mu;g/mL, 50 &amp;mu;g/Ml, 25 &amp;mu;g/mL And 12.5 &amp;mu;g/ mL concentrations against (HepG2) was evaluated using 3-(4,5-Dimethylthiazol- 2yl)-2,5-Diphenyltetrazolium Bromide (MTT) Assay. &lt;strong&gt;Results:&lt;/strong&gt; GC-MS revealed the top three major bioactive compounds of ethyl acetate leaf extract based on quantity (%). These are 1,2,3-propanetriol, monoacetate (21.21%), phytol (20.28%) and squalene (6.85%). MTT assay showed that ethyl acetate extract at different concentrations exhibited marked inhibition of the HepG2. The concentration of the extracts that will inhibit 50% of the cancer cell lines (IC&lt;sub&gt;50&lt;/sub&gt;) was also determined. The assay revealed that compared to positive control (doxorubicin) with IC&lt;sub&gt;50&lt;/sub&gt; 5.068 &amp;mu;g/mL, Ethyl Acetate Extract statistically exhibited greater cytotoxic effect against HepG2 Cell Lines With IC&lt;sub&gt;50&lt;/sub&gt; 1.118 &amp;mu;g/mL (P=0.001). &lt;strong&gt;Conclusion: &lt;/strong&gt;The presence of several bioactive compounds in ethyl acetate extract from the leaves of&lt;em&gt; B. luzonica&lt;/em&gt; confirms the importance of the plant in treatment of diseases. Furthermore, the extract manifested more potent cytotoxic activity than the positive control, indicating promising chemotherapeutic potential of the plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">497</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Franelyne P. Casuga&lt;sup&gt;1,2*&lt;/sup&gt;, Agnes L. Castillo&lt;sup&gt;1,2,3&lt;/sup&gt;, Mary Jho-Anne T. Corpuz&lt;sup&gt;1,2,3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate School, University Of Santo Tomas, Espańa, Manila, PHILIPPINES.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty Of Pharmacy, University Santo Tomas, Espańa , Manila, PHILIPPINES.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Research Center For Natural And Applied Sciences, University Of Santo Tomas, Espańa, Manila, PHILIPPINES&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Omar Mohamed Mohamed Sabry</style></author><author><style face="normal" font="default" size="100%">Abeer Mohamed El Sayed</style></author><author><style face="normal" font="default" size="100%">Salmin Khalid Alshalmani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC/MS Analysis and Potential Cytotoxic Activity of Haplophyllum tuberculatum Essential Oils Against Lung and Liver Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Haplophyllum tuberculatum</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Lung cancer.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">66-69</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Haplophyllum&lt;/em&gt;&lt;em&gt; tuberculatum&lt;/em&gt; is a plant belongs to family rutacee. It is rich in volatile oils, fixed oils, alkaloids, and furanocoumarins. It is well known for the huge number of folkloric uses in middle east. &amp;nbsp;&lt;strong&gt;Objective:&lt;/strong&gt; The aim of this study is to establish the chemical composition of the essential oils of Libyan &lt;em&gt;H. tuberculatum&lt;/em&gt; and to investigate their cytotoxic potentialities. &lt;strong&gt;Materials and Methods&lt;/strong&gt;&lt;strong&gt;:&lt;/strong&gt; The essential oils of the aerial parts and flowers of &lt;em&gt;H. tuberculatum&lt;/em&gt; growing in Libya were prepared by hydrodistillation. GC/MS analyses were performed on a Shimaduz capillary gas chromatograph (GC 17A ver.3) instrument directly coupled to mass spectrometer-MS QP5050A. Oil A and F of &lt;em&gt;H. tuberculatum&lt;/em&gt; at different concentrations (0-50 &amp;micro;g/ml) in DMSO were tested for cytotoxicity against human tumor cell lines. &lt;strong&gt;Results:&lt;/strong&gt; Oil yield was found 0.4 and 1.5 (v/w %) on dry weight basis respectively. GC/MS analysis resulted in identification of total 35 compounds. 15 compounds&amp;nbsp; were common to both oils. oil A of &lt;em&gt;H. tuberculatum &lt;/em&gt;exhibited antitumor activities against&lt;em&gt;.&lt;/em&gt; liver carcinoma cell line (HEPG2) and lung carcinoma cell line (H1299) 4.7 &amp;micro;g/ml and 4.1 &amp;micro;g/ml.&lt;strong&gt; Conclusion:&lt;/strong&gt; Essential oil of the aerial parts of &lt;em&gt;H. tuberculatum&lt;/em&gt; is potentially active against lung (H-1299), and liver (HEPG2) carcinoma cell lines. The observed cytotoxic, activities can be attributed to the dominance of &amp;alpha; and &amp;gamma;-terpinene in this oil.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">66</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Omar Mohamed Mohamed Sabry&lt;sup&gt;1,2*&lt;/sup&gt;, Abeer Mohamed El Sayed&lt;sup&gt;1&lt;/sup&gt;and Salmin Khalid Alshalmani&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Einy Street, 11562, Cairo, Egypt.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Benghazi University, Benghazi, Libya.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shilu Mathew</style></author><author><style face="normal" font="default" size="100%">Muhammad Faheem</style></author><author><style face="normal" font="default" size="100%">Mohd Suhail</style></author><author><style face="normal" font="default" size="100%">Kaneez Fatima</style></author><author><style face="normal" font="default" size="100%">Govindaraju Archunan</style></author><author><style face="normal" font="default" size="100%">Nargis Begum</style></author><author><style face="normal" font="default" size="100%">Muhammad Ilyas</style></author><author><style face="normal" font="default" size="100%">Esam Azhar</style></author><author><style face="normal" font="default" size="100%">Ghazi Abdullah Damanhouri</style></author><author><style face="normal" font="default" size="100%">Ishtiaq Qadri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Updates on Traditional Medicinal Plants for Hepatocellular Carcinoma</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmaceutical Journals</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbs</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">203-214</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;Hepatocellular carcinoma (HCC) is a major worldwide problem primarily caused by hepatitis B and C virus infection. End stage liver cancer treatment options are limited thus requiring expensive liver transplantation which is not available in many countries. &lt;strong&gt;Methods: &lt;/strong&gt;Several herbal compounds and herbal composite formulas have been studied through &lt;em&gt;in-vitro &lt;/em&gt;and &lt;em&gt;in vivo &lt;/em&gt;as an anti-HCC agent, enhancing our knowledge about their biological functions and targets. In this article, arecent update on the herbal medicine has been provided with reference to liver cancer. &lt;strong&gt;Results:&lt;/strong&gt; For the sake of clarity, the effective herbal compounds, clinical studies of herbal composite formula, cell culture, and animal model studies safety are discussed. The effects of many herbal active compounds of &lt;em&gt;Annona atemoya,&lt;/em&gt; &lt;em&gt;Andrographis paniculata, Boerhaviadiffusa,&lt;/em&gt; &lt;em&gt;Piper longum, Podophyllum&lt;/em&gt; &lt;em&gt;hexandrum, Phyllanthus amarus, &lt;/em&gt;and &lt;em&gt;Terminalia chebula&lt;/em&gt;, and herbal composite formula on autophagy, apoptosis, antioxidant, and inflammation characteristicshave been provided. &lt;strong&gt;Conclusion: &lt;/strong&gt;This will enhance our understanding&amp;nbsp;on the prevention and treatment of HCC by herbal active compounds&amp;nbsp;and herbal composite formulas.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">203</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shilu Mathew&lt;sup&gt;1,2,3&lt;/sup&gt;, Muhammad Faheem&lt;sup&gt;4&lt;/sup&gt;, Mohd Suhail&lt;sup&gt;5&lt;/sup&gt;, Kaneez Fatima&lt;sup&gt;6&lt;/sup&gt;, Govindaraju Archunan&lt;sup&gt;3&lt;/sup&gt;, Nargis Begum&lt;sup&gt;1&lt;/sup&gt;, Muhammad Ilyas&lt;sup&gt;7&lt;/sup&gt;, Esam Azhar&lt;sup&gt;5&lt;/sup&gt;, Ghazi Abdullah Damanhouri&lt;sup&gt;5&lt;/sup&gt; and Ishtiaq Qadri&lt;sup&gt;5&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Postgraduate Department of Biotechnology, Jamal Mohamed College, Tiruchirappalli, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, SAUDI ARABIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Animal Science, Bharathidasan University, Tiruchirappalli, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biosciences, Faculty of Sciences, COMSATS Institute of Information Technology, Islamabad, PAKISTAN.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Biotechnology and Translational Medicine Research, King Fahd Medical Research Center, King Abdul Aziz University, PO Box 80216, SAUDI ARABIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;IQ Institute of Infection and Immunity, Lahore, PAKISTAN.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Botany, Jamal Mohamed College, Tiruchirappalli, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>