<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neneng Siti Silfi Ambarwati</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Yesi Desmiaty</style></author><author><style face="normal" font="default" size="100%">Ayun Erwina Arifianti</style></author><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tyrosinase Inhibitory Activity of Garcinia latissima Miq. Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia latissima Miq.</style></keyword><keyword><style  face="normal" font="default" size="100%">Succesive maceration</style></keyword><keyword><style  face="normal" font="default" size="100%">Tyrosinase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1673-1677</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Tyrosinase is an enzyme that plays an essential part in the process of melanin synthesis. High exposure to ultraviolet (UV) radiation or high stimulation of melanocytes could cause excessive melanin pigments to lead to hyperpigmentation. &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to find potential natural skin lightening ingredients from &lt;em&gt;Garcinia latissima &lt;/em&gt;Miq. &lt;strong&gt;Methods:&lt;/strong&gt; Stem bark, fruits, and leaves of &lt;em&gt;Garcinia latissima&lt;/em&gt; Miq. were extracted with successive maceration. The tyrosinase inhibitory activity test was measured spectrophotometrically at 490 nm using 3,4-dihydroxy-L-phenylalanine (L-DOPA) as substrate and kojic acid as a positive control. &lt;strong&gt;Results:&lt;/strong&gt; The tyrosinase inhibitory activity test at a concentration of 100 ppm showed that the bark ethyl acetate extract 15.94% ± 7.70, bark methanol extract of 28.94% ± 5.73, fruit n-hexane extract 25.16% ± 10.22, fruit methanol extract 23.26% ± 9.10; and leaf methanol extract 30.59% ± 0.63 with kojic acid inhibition 65.07%. &lt;strong&gt;Conclusion:&lt;/strong&gt; Methanol extract of leaf from Garcinia latissima Miq was the most active extract as a tyrosinase inhibitor.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1673</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Neneng Siti Silfi Ambarwati&lt;sup&gt;1,&lt;/sup&gt;*, Berna Elya&lt;sup&gt;2&lt;/sup&gt;, Yesi Desmiaty&lt;sup&gt;3&lt;/sup&gt;, Ayun Erwina Arifianti&lt;sup&gt;4&lt;/sup&gt;, Islamudin Ahmad&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Cosmetology Department, Faculty of Engineering, Universitas Negeri Jakarta, Jl. Rawamangun Muka, East Jakarta, Jakarta 13220, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacognosy, Faculty of Pharmacy, Universitas Pancasila, Jl. Srengseng Sawah, Jagakarsa, South Jakarta, Jakarta 12640, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, East Kalimantan, INDONESIA.&lt;/p&gt;
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