<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Intan Kris Prasetyanti</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author><author><style face="normal" font="default" size="100%">Suharjono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">ADMET Prediction and In silico Analysis of Mangostin Derivatives and Sinensetin on Maltase-Glucoamylase Target for Searching Anti-Diabetes Drug Candidates</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Maltase-glucoamylase</style></keyword><keyword><style  face="normal" font="default" size="100%">Mangostin derivatives</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Sinensetin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">883-889</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetes mellitus (DM) is a complex chronic disease with hyperglycemia, which is glucose levels above normal whose number of sufferers is increasing. By inhibiting the human maltase-glucoamylase enzyme which is included in the starch-digestion pathway are used to delay glucose production and thus aid in the treatment of type II diabetes.&lt;strong&gt; Aims and Methods:&lt;/strong&gt; To analyze the potential of mangostin derivatives (alpha-mangostin, betamangostin, gamma-mangostin) and sinensetin as anti-diabetes through ADMET prediction and &lt;em&gt;in silico&lt;/em&gt; tests against human maltase-glucoamylase targets using the docking method with miglitol was used as a control. &lt;strong&gt;Result:&lt;/strong&gt; The ligands ɑ, β, γ-mangostin and sinensetin have good interactions with macromolecules and form hydrogen bonds also van der Waals on the macromolecule active side of human maltase-glucoamylase. &lt;strong&gt;Conclusion: &lt;/strong&gt;The ADMET of mangostin derivatives (ɑ, β, and γ), and sinensetin can be predicted by the pkCSM online tool, and they showed good affinity on maltase-glucoamylase target compared to standard drugs like miglitol.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">883</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Intan Kris Prasetyanti&lt;sup&gt;1&lt;/sup&gt;, Sukardiman&lt;sup&gt;2,&lt;/sup&gt;*, Suharjono&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Magister Program of Pharmaceutical Sciences, Faculty of Pharmacist, Airlangga University, Campus C UNAIR Jl. DR. Ir. H Soekarno Mulyorejo 60115, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacist, Airlangga University, Campus C UNAIR Jl. DR. Ir. H Soekarno Mulyorejo 60115, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Practical Pharmacy, Faculty of Pharmacist, Airlangga University, Campus C UNAIR Jl. DR. Ir. H Soekarno Mulyorejo 60115, Surabaya, INDONESIA.&lt;/p&gt;
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