<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hareg Zewdu Alehegn</style></author><author><style face="normal" font="default" size="100%">Abiodun A. Adeyemi</style></author><author><style face="normal" font="default" size="100%">Abayomi Mayowa Ajayi</style></author><author><style face="normal" font="default" size="100%">Foluke A. Fasola</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Phytochemical, Antioxidant, Anti-sickling, and Membrane Stabilization Properties of Justicia carnea Leaves and Stems Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Sickle Cell Disease</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">1-7</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sickle cell disease (SCD) is an autosomal recessive inherited genetic blood disorder resulting from the aberrant structure of hemoglobin (Hb) that results in the production of hemoglobin S (Hb S). Objective: This study aimed to investigate the phytochemical profiles, antioxidant, anti-sickling, and membrane stabilizing activities of crude extracts of &lt;em&gt;Justicia carnea &lt;/em&gt;leaves and stems that used to treat SCD in Nigeria. &lt;strong&gt;Methods:&lt;/strong&gt; The 70 % ethanol crude extracts of the dried, powdered leaves and stems of &lt;em&gt;J. carnea&lt;/em&gt; were prepared by maceration. Reversal and inhibition activity of the plant materials were evaluated by using sodium-metabisulphite-sickled HB SS blood cells from two patients not in crisis. The membrane stabilization assays on rats' red blood cells (RBCs) and human sickled RBCs and antioxidant assays were determined following standard methods. Results were presented as Mean ± SEM. Data analysis and graph plotting were carried out using GraphPad Prism® version 8.01.&lt;strong&gt; Results:&lt;/strong&gt; The antioxidant assays indicated that &lt;em&gt;J. carnea&lt;/em&gt; leaves (JCL) had stronger DPPH activity (IC₅₀ = 245.031 ± 0.228 μg/mL). While, the stems (JCS) exhibited higher NO scavenging (84.123 ± 0.497 μg/mL). The highest reversal and inhibition percentages observed at 60, 90, and 120-minute time points. At 60th minutes reading, JCL 20 mg/mL (78.9±0.13%) demonstrated the highest reversal activity, while JCL 10 mg/mL (66.9±0.82 %) revealed the strongest inhibition effect. The extracts showed dose-dependent membrane stabilization activity. &lt;strong&gt;Conclusions: &lt;/strong&gt;The extracts demonstrated remarkable antioxidant, anti-sickling, and membrane stabilizing activities. The use of this plant could be a promising natural therapy for SCD.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hareg Zewdu Alehegn&lt;sup&gt;1,2*&lt;/sup&gt;, Abiodun A. Adeyemi&lt;sup&gt;3&lt;/sup&gt;, Abayomi Mayowa Ajayi&lt;sup&gt;4&lt;/sup&gt;, Foluke A. Fasola&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;M.Sc. Candidate, Medicinal Plants Research and Drug Development, Pan African University, Life and Earth Sciences Institute (Including Health and Agriculture), Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, ETHIOPIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Senior Lecturer, Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Senior Lecturer, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Reader/Consultant Haematologist Department of Haematology, College of Medicine, University of Ibadan/University College Hospital, Ibadan, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afriwardi</style></author><author><style face="normal" font="default" size="100%">Adrul Fauzan</style></author><author><style face="normal" font="default" size="100%">Salman Umar</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Complete Blood Profile after administration of Hydrocotyle sibthorpioides Lam. extract in capsule form</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Banded neutrophil</style></keyword><keyword><style  face="normal" font="default" size="100%">Basophils</style></keyword><keyword><style  face="normal" font="default" size="100%">Eosinophils</style></keyword><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Haematology</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematocrit</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrocotile sibthorpioides Lam.</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunostimulants</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Lymphocyte</style></keyword><keyword><style  face="normal" font="default" size="100%">Monocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Segmented neutrophil</style></keyword><keyword><style  face="normal" font="default" size="100%">Thrombocytes.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">375-383</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam.) has been studied as an immunostimulant, increasing macrophage cell activity and phagocytosis capacity. Based on that circumstance, the study aims to prove the immunostimulating effect by measuring the activity of &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. extract in the capsule for the complete blood profile of healthy volunteers. The number of volunteers used was twenty people, and the volunteers were divided into two groups. The first group was given a placebo capsule without &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. extract. The second group was given a capsule with &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. extract with a dose of 67 mg, which was taken once a day for three days. Blood sampling was obtained before and after taking the capsule preparation. Observation of the complete blood profile was conducted by investigating changes in blood parameters such as haemoglobin levels, number of erythrocytes, number of leukocytes, hematocrit values, number of thrombocytes and the percentage of leukocyte types (banded neutrophils, segmented neutrophils, eosinophils, basophils, monocytes, and lymphocytes). The second group given &lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;Lam. extract showed a significant effect on the increase in haemoglobin levels, number of thrombocytes and hematocrit values (p&amp;lt;0.05). The percentage of leukocyte type values showed that lymphocytes increased significantly (p&amp;lt;0.05). In contrast, the segmented neutrophil increased but did not show a significant difference with the percentage of banded neutrophils, eosinophils, basophils and monocytes (p&amp;gt;0.05). There was a nonsignificant result in all parameters for the first group, which was administrated with a placebo capsule without &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. extract.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">375</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Afriwardi&lt;sup&gt;1,*&lt;/sup&gt;, Adrul Fauzan&lt;sup&gt;2&lt;/sup&gt;, Salman Umar&lt;sup&gt;2&lt;/sup&gt; , Yufri Aldi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Andalas, Padang, West Sumatra, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Universitas Andalas, Padang, West Sumatra, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Resta Angelia</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethanol Extract Activity of Pegagan Embun (Hydrocotyle sibthorpioides L.) Against Hematopoietic on Anemic Male White Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract of Hydrocotyle sibthorpioides L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematocrit</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Reticulocytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">866-873</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) is known to have many benefits, including as a blood booster. This study aims to determine the activity of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) on the formation of red blood cells. The parameters include the number of erythrocytes, reticulocytes, hemoglobin levels, and hematocrit values in anemic male white mice induced by chloramphenicol 130 mg/kg for 14 days. &lt;strong&gt;Methods:&lt;/strong&gt; Anemic mice consisted of 4 groups, namely the first group was given physiological NaCl, the second, third, and fourth groups were given ethanol extract of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) at a dose of 10, 50 and 100 mg/kgper oral every day, for 14 days. Observations were made on days 0, 14, 21, and 28. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that administration of pegagan embun extracts at a dose of 10, 50, and 100 mg/kgto anemic male white mice significantly increase the number of erythrocyte cells, the number of reticulocytes, the hemoglobin levels, and the hematocrit values (p &amp;lt;0.05). Increasing the dose and duration of pegagan embun extract administration could provide a more significant increase in the hematopoietic parameters (p &amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt;It can be concluded that the extract of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) can be used to treat anemia in male white mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">866</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Dwisari Dillasamola, Elsa Badriyya, Resta Angelia, Yufri Aldi&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, University Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anupam Jaiswal</style></author><author><style face="normal" font="default" size="100%">Aditya Ganeshpurkar</style></author><author><style face="normal" font="default" size="100%">Ankita Awasthi</style></author><author><style face="normal" font="default" size="100%">Divya Bansal</style></author><author><style face="normal" font="default" size="100%">Nazneen Dubey</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Effects of Beetroot Extract against Phenyl Hydrazine Induced Anemia in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Beta vulgaris</style></keyword><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">phenyl hydrazine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2nd July 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">1-4</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Anemia can be regarded as one of the oldest blood malformation known over a century. Megaloblastic anemia arises due to curtailed formation of erythrocytes, which leads to formation of a large number of underdeveloped erythrocytes. Proper nutritional supplementation may be useful in such condition. &lt;em&gt;Beta vulgaris&lt;/em&gt; or beetroot is one of the important vegetables consumed worldwide. The aim of the present work was to evaluate anti-anemic potential of beetroot. &lt;strong&gt;Methods:&lt;/strong&gt; Beetroot was extracted with ethanol. Phytochemical and phytoanalytical studies were performed on extract. Anemia was induced by phenyl-hydrazine. Animals were treated with extract throughout the study for 24 days. The red blood cell (RBC) number and hemoglobin concentration were determined every 3 days for 24 days. &lt;strong&gt;Results:&lt;/strong&gt; Extract was found to be rich in folic acid, ascorbic acid, and iron. Following the induction of anemia, the number of erythrocytes and the hemoglobin concentration decreased by 62.51% and 69.64%, respectively. Administration of standard hematinic preparation and extract (200 mg/kg) resulted in signifi cant increase (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.001; &lt;em&gt;P&lt;/em&gt;&amp;lt; 0.01) in the number of RBCs as well as hemoglobin concentration when compared to the untreated phenyl hydrazine-induced anemic rats. &lt;strong&gt;Conclusion:&lt;/strong&gt; Extract effectively raised the level of hemoglobin and erythrocyte count at dose 200 mg/kg. Vitamin and minerals found in beetroot are most likely active ingredients responsible for its hematinic effects. Still, methodical studies are obligatory to derive its effects on humans.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Beta vulgaris&lt;/em&gt;, erythrocytes, hemoglobin, phenyl hydrazine.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Anupam Jaiswal&lt;sup&gt;1&lt;/sup&gt;, Aditya Ganeshpurkar&lt;sup&gt;1*&lt;/sup&gt;, Ankita Awasthi&lt;sup&gt;1&lt;/sup&gt;, Divya Bansal&lt;sup&gt;2&lt;/sup&gt;, Nazneen Dubey&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Pharmaceutics Research Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India.&lt;/p&gt;</style></auth-address></record></records></xml>