<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meity Ardiana</style></author><author><style face="normal" font="default" size="100%">Nastiti Imana Intansari</style></author><author><style face="normal" font="default" size="100%">Asiyah Nurul Fadila</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Consequences of Hypertension and Obesity on Coronary Heart Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Body Mass Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Cardiovascular Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Coronary Heart Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">High blood pressure</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1331-1335</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Coronary heart disease (CHD) is the leading cause of death worldwide. At present, more than 20 million adults suffer from CHD, and the number keeps increasing. Hypertension and obesity, known risk factors of CHD, are also inclining in prevalence. Given the diversities of world population, studies on correlation of hypertension and obesity in the incidence of CHD still have a lot to unveil. &lt;strong&gt;Aim:&lt;/strong&gt; to analyze the association between hypertension and obesity to CHD as both independent and dependent risk factors. &lt;strong&gt;Method: &lt;/strong&gt;A cross-sectional descriptive study on 100 hypertensive subjects was conducted from March to November 2022. Subjects were selected by simple random sampling technique. The data were collected by anamnesis, physical examination, laboratory examination, electrocardiography, and by checking on medical records if needed. Statistical analysis was conducted using SPSS. &lt;strong&gt;Result:&lt;/strong&gt; The mean age of the study samples was 58.64 years old. The mean value of BMI was 25.77 ± 5.21 SD, and 53.6% of the participants was obese. 33% of the subjects were diagnosed with CHD. There was no correlation between obesity and CHD (OR = 0.582, 95% CI = 0.245-1.382); between hypertension on therapy or without therapy and CHD (OR= 0.729, 95% CI= 0.15-15.09). There was also no correlation between length of hypertension and CHD (R= 0.117; p = 0.27). &lt;strong&gt;Conclusion: &lt;/strong&gt;This study shows no significant correlations between hypertension, obesity, and CHD. Whether socioeconomic and demographic profile play a part in the association of hypertension and obesity with CHD, specifically for Indonesian ethnicities, should be studied further.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1331</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Meity Ardiana¹'², Nastiti Imana Intansari¹'²*, Asiyah Nurul Fadila¹'²&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Charlotte Mungho Tata</style></author><author><style face="normal" font="default" size="100%">Constance Rufaro Sewani-Rusike</style></author><author><style face="normal" font="default" size="100%">Olukayode Aremu</style></author><author><style face="normal" font="default" size="100%">Opeoluwa Oyehan Oyedeji</style></author><author><style face="normal" font="default" size="100%">Benedicta Ngwenchi Nkeh-Chungag</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antihypertensive Effects of Osteospermum Imbricatum in Two Hypertensive Rat Models</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">High blood pressure</style></keyword><keyword><style  face="normal" font="default" size="100%">Nω-Nitro-L-arginine methyl ester</style></keyword><keyword><style  face="normal" font="default" size="100%">Spontaneously hypertensive rats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">744-751</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Osteospermum imbricatum &lt;/em&gt;is used traditionally in Eastern Cape, South Africa for the management of hypertension, chest and stomach complaints. This study was aimed at investigating the antioxidant and antihypertensive effects of this plant. &lt;strong&gt;Methods: &lt;/strong&gt;Antioxidant capacity was determined by radical scavenging assays and ferric reducing antioxidant power. Antihypertensive effects after once off treatment with the leaf/root extracts (500 mg/kg) were evaluated in spontaneously hypertensive rats (SHR). The effect of the extracts on established hypertension was determined in Wistar rats treated with Nω-Nitro-L-arginine methyl ester (L-NAME) (40 mg/kg/day) for 4 weeks followed by co-treatment with L-NAME and extracts (200 mg/kg and 400 mg/kg) or amlodipine (5 mg/kg) or normal saline for 4 more weeks. &lt;strong&gt;Results:&lt;/strong&gt; The concentration at which there was 50 % inhibition (IC&lt;sub&gt;50&lt;/sub&gt;) of DPPH radical by the extracts was lower for the leaf extract (0.79 mg/mL) compared to the root extract (1.15 mg/mL). The leaf extract significantly (p&amp;lt;0.01) decreased systolic and diastolic blood pressures in both rat models. &lt;strong&gt;Conclusion: &lt;/strong&gt;The extracts of &lt;em&gt;Omsteospermum imbricatu&lt;/em&gt; have moderate antioxidants and antihypertensive properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">744</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Charlotte Mungho Tata&lt;sup&gt;1&lt;/sup&gt;, Constance Rufaro Sewani- Rusike&lt;sup&gt;1&lt;/sup&gt;, Olukayode Aremu&lt;sup&gt;1&lt;/sup&gt;, Opeoluwa Oyehan Oyedeji&lt;sup&gt;2&lt;/sup&gt;, Benedicta Ngwenchi Nkeh- Chungag&lt;sup&gt;3,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Human Biology, Faculty of Health Sciences, Walter Sisulu University, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Science and Agriculture, University of Fort Hare, PBX1314 Alice, 5700 Eastern Cape Province, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biological and Environmental Sciences, Faculty of Natural Sciences, Walter Sisulu University, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;
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