<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sawitree Wongtangtintharn</style></author><author><style face="normal" font="default" size="100%">Sirirath McCloskey</style></author><author><style face="normal" font="default" size="100%">Rungruedee Thiwthong</style></author><author><style face="normal" font="default" size="100%">U-sa Thongpairoj</style></author><author><style face="normal" font="default" size="100%">Surapong Rattana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Free Radical Scavenging and Anticancer Activities of Methanolic Twig Extract of Annonaceae Plant</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annonaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer cell selectivity</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Goniothalamus elegans</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">362-365</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The Annonaceae family represents a promising source of bioactive compounds with potential therapeutic applications. This study aimed to comprehensively evaluate the antioxidant and anticancer potential of methanolic twig extracts from seven Annonaceae species. &lt;strong&gt;Methods: &lt;/strong&gt;Twig specimens from &lt;em&gt;Cananga latifolia, Goniothalamus elegans, Goniothalamus tamirensis, Melodorum fructicosum, Polyalthia dubia, Polyalthia cerasoides&lt;/em&gt;, and &lt;em&gt;Uvaria fauveliana&lt;/em&gt; were subjected to standardized methanolic extraction. Antioxidant activity was assessed using DPPH radical scavenging assay. Anticancer potential was evaluated through Sulforhodamine B assay against three human cancer cell lines and normal human dermal fibroblasts at 25 μg/mL concentration. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;Goniothalamus elegans&lt;/em&gt; demonstrated exceptional antioxidant activity (IC50 = 5.62 ± 1.21 μg/mL) comparable to ascorbic acid. In anticancer evaluation, &lt;em&gt;G. elegans &lt;/em&gt;exhibited remarkable cytotoxicity against MCF-7 (95.19 ± 0.62%) and HeLa (94.46 ± 1.69%) cancer cells while demonstrating exceptional selectivity with minimal toxicity toward normal cells (19.72 ± 1.19%). Melodorum fructicosum showed highest activity against HT-29 colon cancer cells (75.84 ± 1.57%). &lt;strong&gt;Conclusions:&lt;/strong&gt; &lt;em&gt;Goniothalamus elegans&lt;/em&gt; demonstrated exceptional dual bioactivity with both potent antioxidant properties and selective anticancer effects. The remarkable selectivity indices and broad-spectrum anticancer activity suggest significant clinical potential. These findings provide scientific validation for traditional medicinal uses of Annonaceae species.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">362</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sawitree Wongtangtintharn&lt;sup&gt;1&lt;/sup&gt;, Sirirath McCloskey&lt;sup&gt;2&lt;/sup&gt;, Rungruedee Thiwthong&lt;sup&gt;3&lt;/sup&gt;, U-sa Thongpairoj&lt;sup&gt;3&lt;/sup&gt;, Surapong Rattana&lt;sup&gt;4*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Animal Science, Faculty of Agriculture, Khon Kaen University, Khon Kaen, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Science, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Science, Faculty of Education, Nakhon Phanom University, Nakhon Phanom, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nur Ain Sabrina Azmi</style></author><author><style face="normal" font="default" size="100%">Nurdiana Samsulrizal</style></author><author><style face="normal" font="default" size="100%">Siti Aimi Sarah Zainal Abidin</style></author><author><style face="normal" font="default" size="100%">Noor Syaffinaz Noor Mohamad Zin</style></author><author><style face="normal" font="default" size="100%">Norol Hamiza Zamzuri</style></author><author><style face="normal" font="default" size="100%">Yong Meng Goh</style></author><author><style face="normal" font="default" size="100%">Ana Sharmila Shafie</style></author><author><style face="normal" font="default" size="100%">Rohaizad Abdul Raoof</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Functional Beverages from Blends of Ficus Deltoidea Leaves and Brown Rice Powders: Physico-Phytochemical Properties, Antioxidant Activities, Sensory Evaluation and Acute Toxicity Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">9-point hedonic scale.</style></keyword><keyword><style  face="normal" font="default" size="100%">Animal study</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Functional beverages</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">477-489</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Ficus deltoidea&lt;/em&gt; (Ficus: Moraceae) has great potential as a functional food. Administration of &lt;em&gt;F. deltoidea&lt;/em&gt; has been reported to reduce hyperglycemia, oxidative stress and increase insulin secretion in diabetic rats and humans. However, the poor bioavailability and intestinal absorption of &lt;em&gt;F. deltoidea &lt;/em&gt;impede its therapeutic effectiveness at a lower dosage, thus integrating &lt;em&gt;F. deltoidea&lt;/em&gt; into brown rice will provide additional advantages. This study aimed to examine the phyto-physicochemical profile, antioxidant properties, consumer acceptance, and safety of beverages formulated from fine powder mixtures of &lt;em&gt;F. deltoidea&lt;/em&gt; leaves and brown rice. &lt;strong&gt;Methods&lt;/strong&gt;: The new beverage formulations were prepared by mixing the fine powders of &lt;em&gt;F. deltoidea l&lt;/em&gt;eaves with brown rice at ratios of 1:6 and 1:13, respectively. Physicochemical, phytochemical, and antioxidant analyses were performed to characterize the prepared beverages. Consumer acceptance was assessed utilising a 9-point hedonic scale and an acute toxicity study was employed to determine the safety of &lt;em&gt;F. deltoidea-&lt;/em&gt;added formulations. &lt;strong&gt;Results&lt;/strong&gt;:&lt;em&gt; F. deltoidea&lt;/em&gt; decreased the pH and increased the moisture content, ash, and viscosity of a brown rice beverage. The total phenolic, flavonoid, and tannin content as well as antioxidant activities increased significantly in both&lt;em&gt; F. deltoidea-&lt;/em&gt;added formulations. The oral LD&lt;sub&gt;50 &lt;/sub&gt;of the&lt;em&gt; F. deltoidea&lt;/em&gt;-added formulation was higher than 2000 mg/kg body weight. &lt;strong&gt;Conclusions:&lt;/strong&gt; These results suggest that adding &lt;em&gt;F. deltoidea&lt;/em&gt; leaves to brown rice beverages is safe to consume and improves the phyto-physicochemical profile, antioxidant activities, and consumers’ acceptance of the formulation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">477</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nur Ain Sabrina Azmi&lt;sup&gt;1&lt;/sup&gt;, Nurdiana Samsulrizal&lt;sup&gt;1,5,*&lt;/sup&gt;, Siti Aimi Sarah Zainal Abidin&lt;sup&gt;1&lt;/sup&gt;, Noor Syaffinaz Noor Mohamad Zin&lt;sup&gt;1&lt;/sup&gt;, Norol Hamiza Zamzuri&lt;sup&gt;2&lt;/sup&gt;, Yong Meng Goh&lt;sup&gt;3&lt;/sup&gt;, Ana Sharmila Shafie&lt;sup&gt;1,4&lt;/sup&gt;, Rohaizad Abdul Raoof&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Business Management, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300 Puncak Alam, Selangor, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), Serdang, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Industrial Biotechnology Research Centre, SIRIM Berhad, Persiaran Dato’ Menteri, Seksyen 2, 40450 Shah Alam, Selangor, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Bio Fluid Sdn Bhd, 70, Jalan Bulan U5/172, Subang 2, 40150 Shah Alam, Selangor, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anita Kumari Tharu</style></author><author><style face="normal" font="default" size="100%">Mukti Ram Paudel</style></author><author><style face="normal" font="default" size="100%">Ananda Prakash Joshi</style></author><author><style face="normal" font="default" size="100%">Laxman Bhandari</style></author><author><style face="normal" font="default" size="100%">Hari Prasad Aryal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Screening of Secondary Metabolites and Antioxidant Activity of Wild Edible Termite Mushroom</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">phenolic</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Termite mushroom</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">301-307</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Wild edible mushrooms produce a variety of bioactive compounds that are known to have antioxidant properties. Natural antioxidants can protect against oxidative induced free radicals without any side effects. Thus, they are consumed by people for food and nutraceutical values. The purpose of this study was to evaluate the phytochemicals and antioxidant activity of three wild edible termite mushrooms (&lt;em&gt;Termitomyces albuminosus, T. eurhizus and T. robustus&lt;/em&gt;). Different phytochemicals were screened in the 50% ethanol, methanol and water extracts of three termite mushrooms. Total phenolic and flavonoid contents were determined by Folin-Ciocalteau and aluminium chloride method respectively. The antioxidant activity of three termite mushrooms was evaluated by DPPH assay. Qualitative screening of phytochemicals has revealed that alkaloid, steroid, fatty acid, flavonoid, saponin, tannin, carbohydrate and protein are found in the 50% ethanol, methanol and water extracts of three species of termite mushroom. A high amount of total phenolic and flavonoid content was found in the 50% ethanol extract of&lt;em&gt; T. albuminosus, T. eurhizus and T. robustus&lt;/em&gt; (TPC: 50.28, 54.56 and 57.63 mg GAE/g extract; TFC: 16.30, 18.43 and 18.80 mg QE/g extract respectively). Due to high phenolic and flavonoid content, 50% ethanol extract of three termite mushrooms has shown high antioxidant activity (i.e., lowest IC50: 710.00 - 714.05 μg/ml). These termite mushrooms have antioxidant properties due to the presence of bioactive secondary metabolites that can potentially be used as a source of natural antioxidants in the form of food and nutraceutical.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">301</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anita Kumari Tharu&lt;sup&gt;1&lt;/sup&gt;, Mukti Ram Paudel&lt;sup&gt;1&lt;/sup&gt;, Ananda Prakash Joshi&lt;sup&gt;2&lt;/sup&gt;, Laxman Bhandari&lt;sup&gt;3&lt;/sup&gt;, Hari Prasad Aryal&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Central Department of Botany, Tribhuvan University, Kathmandu, NEPAL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Ayshwarya Multiple Campus, Dhangadhi, KAILALI.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;National Medicines Laboratory, Department of Drug Administration, Ministry of Health and Population, Kathmandu, NEPAL&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Apinya Rachkeeree</style></author><author><style face="normal" font="default" size="100%">Kuttiga Kantadoung</style></author><author><style face="normal" font="default" size="100%">Ratchadawan Puangpradub</style></author><author><style face="normal" font="default" size="100%">Ratchuporn Suksathan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemicals, Antioxidants and Anti-tyrosinase Analyses of Selected Ginger Plants</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ABTS assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-tyrosinase</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic content</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Zingiberaceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">872-883</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Some of Zingeberaceae are not widely used for medicine of food, although in Thailand have been used them for many reasons about health or the diet. This study evalued the phytochemicals and anti-tyrosinase activities of 16 plant species of &lt;em&gt;Alpinia, Amomum, Curcuma, Etlingera&lt;/em&gt; and &lt;em&gt;Kaemferia &lt;/em&gt;(Zingiberaceae). &lt;strong&gt;Methods:&lt;/strong&gt; The extractions of dried powdered rhizomes were performed using n-hexane, ethylacetate and ethanol. Percentage extract yield of the samples varied among species and solvent extracts. Chemical groups (alkaloids, flavonoids, tannins, polyphenols, steroids and terpenoids) were identified using phytochemical screening. The total phenolic contents (TPC) were analyzed using the Folin-Ciocalteu’s reagent, while antioxidant activities were detected using 2,2-diphenyl-1- picrylhydrazyl (DPPH) and the 2,2’-azino-bis (3-ethylbenzothizoline-6-sulphonic acid) (ABTS.+). The anti-tyrosinase was expressed to the half maximal inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;) value (mg/mL). &lt;strong&gt;Results:&lt;/strong&gt; The ethyl acetate extract of &lt;em&gt;Amomum &lt;/em&gt;showed the highest value of TPC. The strongest antioxidant activity were found in &lt;em&gt;Amomum&lt;/em&gt; and &lt;em&gt;Kaemferia&lt;/em&gt; extracts, while ethyl acetate and ethanol extracts of all samples have a better antioxidant properties than the n-hexane extracts. On the other hand, the n-hexane extracts have the highest anti-tyrosinase potential in all samples and of these, &lt;em&gt;Curcuma&lt;/em&gt; extracts were the best group. &lt;strong&gt;Conclusion: &lt;/strong&gt;Our research indicated that plants of the Zingiberaceae would be new sources of antioxidants and anti-tyrosinase for further natural product developments in cosmetics, food or nutraceuticals.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">872</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Apinya Rachkeeree, Kuttiga Kantadoung, Ratchadawan Puangpradub, Ratchuporn Suksathan*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Queen Sirikit Botanic Garden, The Botanical Garden Organization, P.O. Box 7 Mae Rim, Chiang Mai, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gan B Bajracharya</style></author><author><style face="normal" font="default" size="100%">Pratigya KC</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A High Antibacterial Efficacy of Fruits of Litsea cubeba (Lour.) Pers from Nepal. GC-MS and Antioxidative Capacity Analyses</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Brine-shrimp assay</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Litsea oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Minimum bactericidal concentration</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">889-893</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Biological activities of the plant materials may vary with different geographic origin. &lt;em&gt;Litsea cubeba &lt;/em&gt;fruits are consumed in Nepal as a spice ingredient and are considered to be possessed antibacterial property. &lt;strong&gt;Objectives:&lt;/strong&gt; Aims of this work are: to compare phytoconstituents present in litsea oil by GC-MS analysis, and to evaluate antibacterial and antioxidant activities of the volatile oil and the fruit extracts. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Hydrodistillation of &lt;em&gt;L. cubeba&lt;/em&gt; fruits was performed to obtain litsea oil followed by extractions with boiling methanol. Fractionations of the extract provided hexane, dichloromethane, ethyl acetate and aqueous extracts. The oil and extracts were analysed for the phytochemicals present. They were evaluated by using antibacterial susceptibility, brine-shrimp lethality and antioxidant capacity assays. &lt;strong&gt;Results:&lt;/strong&gt; All together 49 compounds (accounting 93.66%) were identified in the litsea oil by GC-MS. Monoterpenes being dominant components, the oil constituted 15.96% of citral (geranial and neral). Other major constituents were capric acid (12.44%), β-caryophyllene oxide (7.69%), linalool (5.96%), eucalyptol (5.13%) and cis- β-terpineol (4.22%). Litsea oil, hexane extract and dichloromethane extract displayed very effective antibacterial property. Ethyl acetate extract (LC&lt;sub&gt;50&lt;/sub&gt; = 21.52 μg mL‒1) and litsea oil (LC&lt;sub&gt;50&lt;/sub&gt; = 31.62 μg mL‒1) were found highly cytotoxic against brine-shrimp nauplii. Ethyl acetate (IC&lt;sub&gt;50&lt;/sub&gt; = 124.57 μg mL‒1) and dichloromethane (IC&lt;sub&gt;50&lt;/sub&gt; = 271.08 μg mL‒1) extracts displayed a modest DPPH free radical scavenging activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; Phytoconstituents present in the &lt;em&gt;L. cubeba&lt;/em&gt; fruits from Nepal were analysed. Litsea oil and the extracts have displayed high antibacterial and potentially anticarcinogenic activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">889</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gan B Bajracharya&lt;sup&gt;1,&lt;/sup&gt;*, Pratigya KC&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Science, Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur, NEPAL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu, NEPAL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Srinivasa Reddy Bonam</style></author><author><style face="normal" font="default" size="100%">Sathish Kumar Manoharan</style></author><author><style face="normal" font="default" size="100%">Vijayapandi Pandy</style></author><author><style face="normal" font="default" size="100%">Anji Reddy Raya</style></author><author><style face="normal" font="default" size="100%">Rama Rao Nadendla</style></author><author><style face="normal" font="default" size="100%">Manjunathan Jagadeesan</style></author><author><style face="normal" font="default" size="100%">Ankem Narendra Babu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical, in vitro Antioxidant and in vivo Safety Evaluation of Leaf Extracts of Tragia plukenetii</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dermal toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron chelation</style></keyword><keyword><style  face="normal" font="default" size="100%">Oral toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Tragia plukenetii.</style></keyword><keyword><style  face="normal" font="default" size="100%">β-carotene-linoleic acid complex</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">338-345</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To investigate the phytochemical properties,&lt;em&gt; in vitro&lt;/em&gt; antioxidant and in vivo safety profile of leaf extracts of Tragia plukenetii (TP).&lt;strong&gt; Methods:&lt;/strong&gt; TP leaves were obtained from the south part of India (Guntur District, Andhra Pradesh) and it was extracted with different solvents (benzene extract (BE), chloroform extract (CE) and methanolic extract (ME)). These TP extracts were analyzed for the &lt;em&gt;in vitro&lt;/em&gt; antioxidant activity by DPPH reducing power, β-carotene-linoleic acid complex and iron chelation assays followed by in vivo acute oral and dermal toxicities using Swiss mice and Wistar rats respectively. &lt;strong&gt;Results:&lt;/strong&gt; The present study results revealed ME exhibited an effective and powerful antioxidant activity when compared to a standard antioxidant, butylated hydroxytoluene (BHT). ME was found to be effective in DPPH, β-carotene-linoleic acid complex and iron chelation assays respectively. In vivo acute oral toxicity study revealed that mice treated with up to 5000 mg/kg of BE, CE and ME did not show any signs of toxicity. Furthermore, similarly, acute dermal toxicity study demonstrated that BE, CE and ME did not exhibit any signs of dermal toxicity up to 1000 mg/kg in rats. &lt;strong&gt;Conclusion:&lt;/strong&gt; TP extracts possess an excellent antioxidant activity with a devoid of any signs of acute oral and dermal toxicities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">338</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Srinivasa Reddy Bonam&lt;sup&gt;1,2,&lt;/sup&gt; Sathish Kumar Manoharan&lt;sup&gt;1&lt;/sup&gt;, Vijayapandi Pandy&lt;sup&gt;1,*&lt;/sup&gt;, Anji Reddy Raya&lt;sup&gt;1&lt;/sup&gt;, Rama Rao Nadendla&lt;sup&gt;1&lt;/sup&gt;, Manjunathan Jagadeesan&lt;sup&gt;3,4,&lt;/sup&gt; Ankem Narendra Babu&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, 522034, Andhra Pradesh, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;UMR 7242 CNRS- Neuroimmunology and Peptide Therapy Team, University of Strasbourg, Biotechnology and Cell Signaling (Strasbourg School of Biotechnology, ESBS), Illkirch, 67400, FRANCE.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biotechnology, Vels University, Pallavaram, Chennai-600117, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Research and Development, Sree Balaji Medical College and Hospital, Chromepet, Chennai- 600044, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Balachandran Karpaga Raja Sundari</style></author><author><style face="normal" font="default" size="100%">Srivani Telapolu</style></author><author><style face="normal" font="default" size="100%">Bilikere S</style></author><author><style face="normal" font="default" size="100%">Dwarakanath</style></author><author><style face="normal" font="default" size="100%">Sadras. P. Thyagarajan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic and Antioxidant Effects in Various Tissue Extracts of Plumbago zeylanica: Implications for Anticancer Potential</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A549 Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Alcoholic Root Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC Quantification</style></keyword><keyword><style  face="normal" font="default" size="100%">Plumbagin</style></keyword><keyword><style  face="normal" font="default" size="100%">Transcriptome Analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/pj-9-5/10.5530pj.2017.5.111/index.html</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">706-712</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Complex natural products are emerging as a potent alternate and complement in anticancer therapies due to its multiple mechanisms of action and minimal effects on nontarget cells/tissues. Some of the traditional herbal formulations contain &lt;em&gt;Plumbago zeylanica &lt;/em&gt;L, (commonly known as Chitraka or Chitramoolam) to treat various disorders for centuries in Africa and Asia. &lt;strong&gt;Methods:&lt;/strong&gt; The quantity of Plumbagin was detected in different tissues of &lt;em&gt;P. zeylanica&lt;/em&gt; through HPTLC analysis. We evaluated and compared the alcoholic tissue extracts of leaf, stem and root of &lt;em&gt;P. zeylanica&lt;/em&gt; with standard pure Plumbagin for its &lt;em&gt;in vitro&lt;/em&gt; cytotoxic effects (metabolic viability; MTT assay) in A549 Lung cancer cells and antioxidant potential (DPPH free radical scavenging and total phenol content). RNA sequencing and transcriptome analysis was performed in the most potent tissues of &lt;em&gt;P. zeylanica&lt;/em&gt; demonstrating efficient pharmacological activity. &lt;strong&gt;Results:&lt;/strong&gt; The root extract containing 1.3% of plumbagin exhibited strongest scavenging potential with 50% radical scavenging (IC&lt;sub&gt;50&amp;nbsp;&lt;/sub&gt;value of 3.99 &lt;em&gt;&amp;mu;&lt;/em&gt;g) in comparison with 35.85 &lt;em&gt;&amp;mu;&lt;/em&gt;g in stem (0.2% Plumbagin) and 18.06 &lt;em&gt;&amp;mu;&lt;/em&gt;g in leaf with 0.00007% Plumbagin. The &lt;em&gt;in vitro&lt;/em&gt; cytotoxicity in A549 cells also showed that the root extract was most potent with an IC&lt;sub&gt;50&amp;nbsp;&lt;/sub&gt;value of 164.5&amp;nbsp;&lt;em&gt;&amp;mu;&lt;/em&gt;g as compared to extracts from stem (IC&lt;sub&gt;50&lt;/sub&gt;= 379.5&amp;mu;g) and leaf (IC50= 274.9 &lt;em&gt;&amp;mu;&lt;/em&gt;g). &lt;strong&gt;Conclusion:&lt;/strong&gt; The strong antioxidant potential shown by the &lt;em&gt;P. zeylanica &lt;/em&gt;extract demonstrates its ability to protect the non-target (normal) cells against oxidative stress, while the cytotoxic effects suggest that it could inhibit the growth of cancerous cells. Further, transcriptome analysis predicted the expression of potent gene transcripts coding for quinone biosynthesis in the root tissues of &lt;em&gt;P. zeylanica.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">706</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Balachandran Karpaga Raja Sundari&lt;sup&gt;1*&lt;/sup&gt;, Srivani Telapolu&lt;sup&gt;2&lt;/sup&gt;, Bilikere S. Dwarakanath&lt;sup&gt;3&lt;/sup&gt;, Sadras. P. Thyagarajan&lt;sup&gt;4* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Ph.D. DST-National Post-Doctoral Fellow, Herbal and Indian Medicine Research Laboratory, Central Research Facility, Sri Ramachandra University, Porur, Chennai-600116, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Ph.D Scholar, Herbal and Indian Medicine Research Laboratory, Central Research Facility, Sri Ramachandra University, Chennai-600116, Tamil INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Ph.D., Professor (Research), Central Research Facility, Sri Ramachandra University, Chennai-600 116, Tamil Nadu. INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Ph.D., M.D., D.Sc. Professor of Eminence &amp;amp; Dean (Research), Central Research Facility, Sri Ramachandra University, Chennai-600116, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Saraswati Patel</style></author><author><style face="normal" font="default" size="100%">Mamta Gokhale</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Study of Antioxidant Activity of Ethanol and Aqueous Extracts of Different Parts of Nyctanthes Arbor-tristis Linn.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Aqueous extract</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Nyctanthes arbor-tristis Linn.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">113-116</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Antioxidants play a major role in curing degenerative disease. In present time many synthetic antioxidants are commonly used but due to their toxic and carcinogenic effects, their use has been restricted. So the search for natural antioxidants is important. Studies on natural compounds is of interest due to their satisfactory health benefits with low toxicity. &lt;strong&gt;Objective:&lt;/strong&gt; The antioxidant activity of ethanol and aqueous extract of shoot, seed and leaf of an important medicinal tree &lt;em&gt;Nyctanthes arbor-trist&lt;/em&gt; is (Harsingar) were evaluated by DPPH scavenging antioxidant assays. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Different concentrations 25, 50, 75, 100% of the aqueous and ethanol extracts were prepared with standard solutions (ascorbic acid 0.01, 0.03, 0.05, 0.07, 0.09, 0.1 mg/ml). To 1.5 ml solution of DPPH (0.1 mM), 0.5 ml of various concentrations of the extract and standard were added. &lt;strong&gt;Results&lt;/strong&gt;: In the present study a comparative evaluation of antioxidant activity of seed, shoot and leaf of &lt;em&gt;Nyctanthes arbor-tristis&lt;/em&gt; Linn was performed for their aqueous and ethanol extracts. Ethanol and aqueous extracts of shoot revealed more antioxidant activity then seed and leaf.&lt;strong&gt; Conclusion:&lt;/strong&gt; All aerial parts of &lt;em&gt;Nyctanthes arbor-tristis&lt;/em&gt; Linn possess antioxidant activity. The plant may be functioned out for its anticancerous properties in future.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">113</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Saraswati Patel and Mamta Gokhale* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Botany and Microbiology, St. Aloysius College (autonomous), Jabalpur-M.P., INDIA.&lt;/p&gt;
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