<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anchana Babu</style></author><author><style face="normal" font="default" size="100%">Rekha D Kini</style></author><author><style face="normal" font="default" size="100%">Nayanatara Arun Kumar</style></author><author><style face="normal" font="default" size="100%">Megha Gokul</style></author><author><style face="normal" font="default" size="100%">Vandana Blossom</style></author><author><style face="normal" font="default" size="100%">Sreerag P</style></author><author><style face="normal" font="default" size="100%">Shymala Nayak</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Neuroprotective Potential of Ashwagandha In Aluminum-Induced Toxicity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aluminum Chloride</style></keyword><keyword><style  face="normal" font="default" size="100%">Ashwagandha</style></keyword><keyword><style  face="normal" font="default" size="100%">Malondialdehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Reactive Oxygen Species</style></keyword><keyword><style  face="normal" font="default" size="100%">Reduced glutathione</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">336-341</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction : &lt;/strong&gt;Aluminium is the most abundant metal and the third most common element in the Earth’s crust, following oxygen and silicon. Exposure to aluminium is associated with oxidative damage, primarily due to its ability to disrupt redox balance, generate reactive oxygen species, and impair antioxidant defense mechanisms.This study was aimed to find the potential role of ashwagandha on aluminium induced brain toxicity. &lt;strong&gt;Methods: &lt;/strong&gt;In the present study rats were grouped into 4 groups of 6 rats in each. Brain tissue was removed and processed for biochemical and histopathological analysis. &lt;strong&gt;Results:&lt;/strong&gt; In the present study, administration of aluminium to rats resulted in a significant decrease in tissue GSH levels and a corresponding increase in MDA levels in the aluminium-treated group compared to the normal control.. Treatment with Ashwagandha showed a significant increase in GSH level and decrease in MDA level. Photomicrographic sections of the Brain in Ashwagandha-treated rats showed normla neuronal Count and exposure to Aluminium has caused significant reduction in the neuronal count. Experimental group pretreated with ashwagandha showed a visible increase in neuronal count in different regions of the rat brain.&lt;strong&gt; Conclusion: &lt;/strong&gt;The results revealed that oral administration of aluminium induced adverse oxidative effects in the exposed animals, while treatment with Ashwagandha markedly reduced the extent of aluminium chloride-induced brain injury.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">336</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anchana Babu&lt;sup&gt;1&lt;/sup&gt;, Rekha D Kini&lt;sup&gt;1*&lt;/sup&gt;, Nayanatara Arun Kumar&lt;sup&gt;1&lt;/sup&gt;, Megha Gokul&lt;sup&gt;1&lt;/sup&gt;, Vandana Blossom&lt;sup&gt;2&lt;/sup&gt;, Sreerag P&lt;sup&gt;3&lt;/sup&gt;, Shymala Nayak&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Physiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomy, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Physiology, Srinivas Institute of Medical Sciences &amp;amp; Research Centre, Mukka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anchana Babu</style></author><author><style face="normal" font="default" size="100%">Rekha D Kini</style></author><author><style face="normal" font="default" size="100%">Nayanatara Arun Kumar</style></author><author><style face="normal" font="default" size="100%">Megha Gokul</style></author><author><style face="normal" font="default" size="100%">Bhagyalakshmi K</style></author><author><style face="normal" font="default" size="100%">Sneha Shetty B</style></author><author><style face="normal" font="default" size="100%">Vinodini NA</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Role of Ashwagandha [Withania Somnifera] As An Antioxidant On Aluminium Chloride-Induced Testicular Damage In Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Malondialdehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Reactive Oxygen Species</style></keyword><keyword><style  face="normal" font="default" size="100%">Reduced glutathione</style></keyword><keyword><style  face="normal" font="default" size="100%">Sperm morphology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">583-587</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Aluminium is most prevalent and third most abundant element in earth crust after oxygen. Its exposure in high concentration can accumulate in many organs that damage various organs in living organisms like humans and animals. Although aluminum (Al) is known to induce oxidative damage through various mechanisms including binding to negatively charged phospholipids on the membrane of various tissue cell which are rich in PUFA.Hence,this study was aimed to find the potential role of ashwagandha on aluminum induced testicular toxicity. &lt;strong&gt;Methods: &lt;/strong&gt;Animals were segregated into 4 groups of 6 rats in each. The control group, the Ashwagandha treated group, the Aluminum intoxicated group, pretreated with Ashwagandha with Aluminum intoxicity group. Testicular tissue was removed and were stored in 10% formalin saline and histopathological slides were done . A part of the tissues were processed for estimation of MDA and GSH level. &lt;strong&gt;Results: &lt;/strong&gt;In the present study administration of aluminum in rats showed a significant decrease in the testicular tissue level of GSH and sperm count, as well as increase in the level of MDA and sperm morphology in aluminum treated group compared to normal control. Treatment with Ashwagandha showed a significant increase in testicular GSH level, sperm count and decrease in MDA level sperm morphology. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of this study revealed that oral Aluminum Chloride administration induced adverse oxidative effects on the exposed animals and treatment with&lt;em&gt; W. somnifera &lt;/em&gt;reduced the extent of aluminium chloride-induced tissue injury&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">583</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anchana Babu&lt;sup&gt;1&lt;/sup&gt;, Rekha D Kini&lt;sup&gt;1*&lt;/sup&gt;, Nayanatara Arun Kumar&lt;sup&gt;1&lt;/sup&gt;, Megha Gokul&lt;sup&gt;1&lt;/sup&gt;, Bhagyalakshmi K&lt;sup&gt;1&lt;/sup&gt;, Sneha Shetty B&lt;sup&gt;1&lt;/sup&gt;, Vinodini NA&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Physiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Justil-Guerrero Hugo Jesús</style></author><author><style face="normal" font="default" size="100%">Chávez-Flores Juana Elvira</style></author><author><style face="normal" font="default" size="100%">Cárdenas-Orihuela Robert Armando</style></author><author><style face="normal" font="default" size="100%">Ramos- Jaco Antonio Guillermo</style></author><author><style face="normal" font="default" size="100%">Ñañez-del-Pino Daniel</style></author><author><style face="normal" font="default" size="100%">Vásquez-Quispe Ángel David</style></author><author><style face="normal" font="default" size="100%">Rojas-Cardenas Nathalie Felicita</style></author><author><style face="normal" font="default" size="100%">Fernández-Flores Nélber</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Capacity and Protective Effect of Aqueous and Hydroalcoholic Extracts of Senecio rhizomatus Rusby &quot;Llancahuasi&quot; on Erythrocytes Subjected to Oxidative Stress</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoperoxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasma membrane redox system</style></keyword><keyword><style  face="normal" font="default" size="100%">Reactive Oxygen Species</style></keyword><keyword><style  face="normal" font="default" size="100%">Reduced glutathione</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">516-527</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective. &lt;/strong&gt;To evaluate the antioxidant capacity and protective effect of aqueous and hydroalcoholic extracts of &lt;em&gt;Senecio rhizomatus&lt;/em&gt; Rusby in rat erythrocytes subjected to oxidative stress with hydrogen peroxide (H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;). &lt;strong&gt;Methodology.&lt;/strong&gt; This study used an experimental design. The extracts were obtained through maceration with 96° ethanol (SeR96), 70° ethanol (SeR70), 50° ethanol (SeR50) and through infused water (SeRAc). Secondary metabolites were identified through colorimetric reactions and precipitation. In each extract, we could determine the capacity to eliminate 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), the reduction of ferric ion and the total polyphenol content. In addition, the activity on the plasma membrane redox system (PMRS) was evaluated in each extract. The protection against oxidative stress in erythrocytes was evaluated by determining the content of reduced glutathione (GSH) and malondialdehyde (MDA). &lt;strong&gt;Results.&lt;/strong&gt; Alkaloids, flavonoids, phenolic compounds, sesquiterpene lactones and sugars were identified in all the extracts. The total polyphenols content showed a correlation with the reduction of ferric ion (r=0.885) and with DPPH radicals elimination (r = -0.899), where the one with the highest antioxidant capacity was SeR50. Thus, the SeR50 (all concentrations) and SeR70 (100 μg/mL concentration) significantly increased the PMRS activity compared to the control group. After inducing oxidative stress in erythrocytes, all the extracts maintained the GSH level and inhibited MDA formation significantly compared to the H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; group. &lt;strong&gt;Conclusion.&lt;/strong&gt; The antioxidant capacity of hydroalcoholic extracts (96°, 70°, 50°) and aqueous infusion of &lt;em&gt;Senecio rhizomatus &lt;/em&gt;Rusby is related to the content of polyphenols. They increase the plasma membrane redox system activity in rat erythrocytes and protect them from oxidative stress induced with H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;, showing an increase in the concentration of reduced glutathione and a decrease in malondialdehyde.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">516</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Justil-Guerrero Hugo Jesús&lt;sup&gt;1,&lt;/sup&gt;*, Chávez-Flores Juana Elvira&lt;sup&gt;1&lt;/sup&gt;, Cárdenas-Orihuela Robert Armando&lt;sup&gt;1&lt;/sup&gt;, Ramos-Jaco Antonio Guillermo&lt;sup&gt;1&lt;/sup&gt;, Ñañez-del-Pino Daniel&lt;sup&gt;1&lt;/sup&gt;, Vásquez-Quispe Ángel David&lt;sup&gt;1&lt;/sup&gt;, Rojas-Cardenas Nathalie Felicita&lt;sup&gt;1&lt;/sup&gt;, Fernández-Flores Nélber&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERÚ.&lt;/p&gt;
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