<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ruiz-Reyes SG</style></author><author><style face="normal" font="default" size="100%">Villarreal-La Torre Víctor E</style></author><author><style face="normal" font="default" size="100%">Silva-Correa Carmen R</style></author><author><style face="normal" font="default" size="100%">Sagástegui Guarniz William Antonio</style></author><author><style face="normal" font="default" size="100%">Cruzado-Razco José L</style></author><author><style face="normal" font="default" size="100%">Gamarra-Sánchez César D</style></author><author><style face="normal" font="default" size="100%">Venegas Casanova Edmundo A</style></author><author><style face="normal" font="default" size="100%">Miranda-Leyva Manuel</style></author><author><style face="normal" font="default" size="100%">Valdiviezo Campos Juan Ernesto</style></author><author><style face="normal" font="default" size="100%">Cuellar-Cuellar Armando</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Activity of Cordia lutea Lam Flower Extracts Against Paracetamol‑Induced Hepatotoxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetaminophen</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Cordia lutea</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">309-316</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Paracetamol or acetaminophen overdose leads to hepatotoxicity. This study evaluates the effect of &lt;em&gt;Cordia lutea&lt;/em&gt; extract on paracetamol-induced hepatotoxicity in rats. &lt;strong&gt;Methods:&lt;/strong&gt; Three different doses of dry fluid extract of &lt;em&gt;C. lutea&lt;/em&gt; (200, 400 and 600 mg / Kg) were evaluated and compared with Silymarin 200 mg / Kg. Biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), direct bilirubin, indirect bilirubin, total bilirubin, albumin, globulin and total proteins were evaluated, and histopathological changes in the liver were studied and evaluated. &lt;strong&gt;Results: &lt;/strong&gt;&lt;em&gt;C. lutea &lt;/em&gt;reduced the levels of ALT, AST, ALP and increases proteins significantly, although the reduction of bilirubin was not significant, the extract at 400 mg / Kg reduced the levels better than the extract at 600 mg / Kg. The histopathological evaluation suggested that &lt;em&gt;C. lutea&lt;/em&gt; extract reduced paracetamol-induced liver necrosis. &lt;strong&gt;Conclusions: &lt;/strong&gt;The extract of &lt;em&gt;C. lutea&lt;/em&gt; has a marked hepatoprotective effect, significantly reducing the levels of ALT, AST and ALP, in addition to increasing the levels of albumin, globulin and total proteins, in&lt;em&gt; Rattus norvegicus&lt;/em&gt; var. &lt;em&gt;albinus&lt;/em&gt;.&lt;em&gt; C. lutea &lt;/em&gt;extract is an excellent candidate for use in paracetamol-induced liver diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">309</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ruiz-Reyes SG, Villarreal-La Torre Víctor E*, Silva-Correa Carmen R, Sagástegui Guarniz William Antonio, Cruzado-Razco José L, Gamarra-Sánchez César D, Venegas Casanova Edmundo A, Miranda-Leyva Manuel, Valdiviezo Campos Juan Ernesto, Cuellar-Cuellar Armando&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siordia-Reyes Georgina A</style></author><author><style face="normal" font="default" size="100%">Cornejo-Garrido Jorge</style></author><author><style face="normal" font="default" size="100%">Jiménez-Arellanes M. Adelina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephro- and hepatoprotective effect of Rosmarinus officinalis against damage induced with antiTB drugs using a chronic model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antitubercular drug</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Rosmarinus officinalis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">722-729</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Nephro- and hepatoprotector effect of MeOH extract from &lt;em&gt;R. officinalis&lt;/em&gt; against the liver and kidney damage caused by the mixture of RIF:INH:PZA, using a chronic&lt;em&gt; in vivo&lt;/em&gt; model are described. MeOH extract (EMRO) was prepared by maceration process and was administered by oral via during 91 days in male Balb/C mice with RIF:INH:PZA-induced renal/liver damage, using silymarin (SIL) as a positive control. EMRO (250 mg/kg) favoured body weight gain respect to the antiTB group, this gain was better than that shown by the SIL. The AST and ALT values of the group that received the EMRO extract and SIL were similar to that the control group and low compared to the group antiTB with liver damage. In addition, the GPx, CAT and POx values of the group treated with the EMRO were similar to that the control group. In the liver histological analysis, no significant alteration was observed; however, a severe nephritis was observed in anti-TB group (II) and this effect was less in groups III (antiTB/SIL) and IV (antiTB/EMRO). MeOH extract enhances body weight gain and primarily protects the kidney and liver from damage caused by the antiTB drug mixture when was administered for 91 days.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">722</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siordia-Reyes Georgina A&lt;sup&gt;1&lt;/sup&gt;, Cornejo-Garrido Jorge&lt;sup&gt;2&lt;/sup&gt;, Jiménez- Arellanes M. Adelina&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Patología, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN-SXXI), Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtémoc 330, Col. Doctores, 06720, Ciudad de México (CDMX), MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratorio de Biología Celular y Productos Naturales, Escuela Nacional de Medicina y Homeopatía (ENMH), Instituto Politécnico Nacional, Guillermo Massieu Helguera 239, Col. La Escalera, Del. Gustavo A. Madero, 07320 CDMX, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Unidad de Investigación Médica (UIM) en Farmacología, UMAE Hospital de Especialidades, CORSE 2º piso, CMN-SXXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, 06729, CDMX, MEXICO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dandare Shamsudeen Umar</style></author><author><style face="normal" font="default" size="100%">Bawa Muhammad</style></author><author><style face="normal" font="default" size="100%">Wasagu Ibrahim Zubairu</style></author><author><style face="normal" font="default" size="100%">Magaji Umar Faruk</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Effect of Quail Egg Against Carbontetrachloride (CCl4) Induced Hepatic Damage in Albino Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carbon tetrachloride</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology.</style></keyword><keyword><style  face="normal" font="default" size="100%">Quail egg</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Dec, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">102-106</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Quail egg has been used traditionally in the treatment of many ailments. Despite the wide speculations of its involvement in the treatment of liver diseases, very little scientific evidence exist to support this claim. This work investigated the hepatoprotective effect of quail egg against carbon tetrachloride (CCl&lt;sub&gt;4&lt;/sub&gt;) induced liver damage in albino rats.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The rats were divided into five groups of five rats per group. Animals of group A (positive control) were fed with vehicle (distilled water) on the first four days and with vehicle and CCl4 on the fifth, sixth and seventh day. Animals of group B (negative control) were given only vehicle for seven days. Animals of groups C, D and E were respectively administered with 100, 200 and 400 mg/kg body weight of quail egg for the first four days and with vehicle, quail egg and CCl&lt;sub&gt;4&lt;/sub&gt; for the fifth, sixth and seventh day. Animals were subsequently anaesthetized, and blood samples were taken for the estimation of albumin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein (TP) and bilirubin. The liver was isolated for histopathological studies. &lt;strong&gt;Results: &lt;/strong&gt;The levels of ALT, ALP and TP were significantly affected (p &amp;lt; 0.05) in CCl&lt;sub&gt;4&lt;/sub&gt; fed groups, indicating liver injury. The effects were reduced significantly (p &amp;lt; 0.05) after treatment of rats with quail egg. Furthermore, histopathological studies of the liver tissues also supported the hepatoprotective activity of quail egg- photomicrographs of treated groups showed mild reduction in vacuolarisation/ballooning degeneration of the hepatocytes. &lt;strong&gt;Conclusion: &lt;/strong&gt;Quail egg showed some potentials of protecting the liver from damage by stabilising the levels of ALP, ALT and TP and reducing the degeneration of the hepatocytes. Thus, this finding has provided information that suggests utilising quail egg for treatment of liver dysfunction.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key Words: &lt;/strong&gt;Quail egg, Carbon tetrachloride, Hepatotoxicity, Hepatoprotection, Histopathology.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">102</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Dandare Shamsudeen Umar&lt;sup&gt;1*&lt;/sup&gt;, Bawa Muhammad&lt;sup&gt;1&lt;/sup&gt;, Wasagu Ibrahim Zubairu&lt;sup&gt;2&lt;/sup&gt; and Magaji Umar Faruk&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Science,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemical Pathology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.&lt;/p&gt;</style></auth-address></record></records></xml>