<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aasia Kanwal</style></author><author><style face="normal" font="default" size="100%">Muhammad Hamdi Mahmood</style></author><author><style face="normal" font="default" size="100%">Mahad Butt</style></author><author><style face="normal" font="default" size="100%">Hidayat Ur Rahman</style></author><author><style face="normal" font="default" size="100%">Norhida Ramli</style></author><author><style face="normal" font="default" size="100%">Saiful Bahri Talip</style></author><author><style face="normal" font="default" size="100%">Showkat Ahmad Bhawani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Components of Gamma Oryzanol on Toll-Like Receptor 4: Receptor Structure-Based Pharmacophore, Hit Identification, and In Silico Evidence</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Gamma oryzanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Infertility</style></keyword><keyword><style  face="normal" font="default" size="100%">Polycystic ovarian syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">TLR4 antagonist</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">329-335</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Polycystic ovarian syndrome is a leading cause of female infertility. Inflammation has a central role in infertility. Persistent activation of Toll-like receptor 4 contributes to inflammation in PCOS. Gamma-oryzanol consists of esters of ferulic acid combined with phytosterols and triterpene alcohol derivatives of rice bran oil, and is known to have anti-inflammatory effects. However, the structural interaction of different gamma-oryzanol compounds with TLR4 remains unknown. &lt;strong&gt;Objectives: &lt;/strong&gt;The study aimed to investigate gamma oryzanol compounds as hit compounds and inhibitors of Toll-like receptor 4 by developing a pharmacophore model through a receptor structure-based approach coupled with molecular docking studies with the Molecular Operating Environment (MOE) software. &lt;strong&gt;Methods: &lt;/strong&gt;A structure-based pharmacophore model was generated from the co-crystalized structure of the TLR4– MD2 complex. Gamma-oryzanol derivatives were evaluated against the constructed pharmacophore model to identify potential hit compounds. The potential hit compounds that satisfied essential pharmacophoric features were subjected to molecular docking with TLR4. &lt;strong&gt;Results:&lt;/strong&gt; The pharmacophore consisted of three characteristics: a hydrogen bond donor, a hydrogen bond acceptor, and a hydrophobic. Cycloartenyl ferulate, 24-methylenecycloartenyl ferulate, Campesteryl ferulate, and β-sitosteryl ferulate were found to be the hit compounds against the generated pharmacophore. The docking experiment showed that Cycloartenyl ferulate had the most potent binding interaction with TLR4 (7.9933), followed by 24-methylenecycloartenyl ferulate (-7.8580), Campesteryl ferulate (-6.1675), and β-sitosteryl ferulate (-5.9673). &lt;strong&gt;Conclusion: &lt;/strong&gt;The present pharmacophore modeling and docking findings predict that gammaoryzanol may bind with the TLR4 ligand binding domain, providing structural insights into their therapeutic potential role as a modulator of the TLR4-mediated inflammatory pathway. These findings provide a theoretical foundation for future in vitro and in vivo validation studies aimed at elucidating the mechanistic basis of gamma-oryzanol’s anti-inflammatory activity in PCOS.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">329</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aasia Kanwal&lt;sup&gt;1*&lt;/sup&gt;, Muhammad Hamdi Mahmood&lt;sup&gt;1&lt;/sup&gt;, Mahad Butt&lt;sup&gt;2&lt;/sup&gt;, Hidayat Ur Rahman&lt;sup&gt;1&lt;/sup&gt;, Norhida Ramli&lt;sup&gt;1&lt;/sup&gt;, Saiful Bahri Talip&lt;sup&gt;1&lt;/sup&gt;, Showkat Ahmad Bhawani&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine &amp;amp; Health Sciences, Universiti Malaysia Sarawak, 94300 Kota Samarahan, MALAYSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medicine, Allama Iqbal Medical College, 54550 Lahore, PAKISTAN. 3Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Akingbolabo Daniel Ogunlakin</style></author><author><style face="normal" font="default" size="100%">Oyindamola Esther Awosola</style></author><author><style face="normal" font="default" size="100%">Gbenga Temidayo Ajayi</style></author><author><style face="normal" font="default" size="100%">Oluwafemi Adeleke Ojo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Review on Phytochemistry of Medicinal Plants Documented for the Treatment of Low Sperm Count in Oluponna, Nigeria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ancestral medicinal plants records</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug development.</style></keyword><keyword><style  face="normal" font="default" size="100%">Infertility</style></keyword><keyword><style  face="normal" font="default" size="100%">Low sperm count</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">439-446</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;According to the literature, approximately 32% of adult males in developing countries suffer from infertility, however, majority of them use herbal remedies with reported benefits such as improved sperm quality, sexual functions, libido and testosterone levels. Recently, the World Health Organization emphasized the importance of documenting active medicinal plants used in various continents. Therefore, this present review focused on the phytochemistry of medicinal plants reported for the treatment of low sperm count in Oluponna area of Osun state, documented in an ancestral local record. Thirteen medicinal plants were documented to be used for management of low sperm count among men in this community. The plants listed in the document belong to ten families and 12 genera. The most cited family in this record is Apocynaceae with three species of plants namely, &lt;em&gt;Alstonia boonei,&lt;/em&gt; &lt;em&gt;Laidolphia dulcis&lt;/em&gt;, and &lt;em&gt;Rauwolfia vomitoria&lt;/em&gt; respectively. Since this is the first review on the documentation of an ancestral knowledge and application of medicinal plants as means of passing the knowledge from a generation to another in Oluponna, additional toxicological and pharmacological studies are hereby recommended in order to provide scientific rationale for the long-term knowledge and use of these plants.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">439</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Akingbolabo Daniel Ogunlakin&lt;sup&gt;1,2,*&lt;/sup&gt;, Oyindamola Esther Awosola&lt;sup&gt;3&lt;/sup&gt;, Gbenga Temidayo Ajayi&lt;sup&gt;4&lt;/sup&gt;, Oluwafemi Adeleke Ojo&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Bowen University SDG 03 (Good Health and Wellbeing Research Cluster), NIGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Phytomedicine, Molecular Toxicology and Computational Biochemistry Research Group, Department of Biochemistry, Bowen University, Iwo, NIGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Next Era Health, Julius Kadir street, Ifako- Gbagada, Lagos, NIGERA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;College of Health Sciences, Bowen University, Iwo, NIGERA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Fitri Rachmaini</style></author><author><style face="normal" font="default" size="100%">Dian Ayu Juwita</style></author><author><style face="normal" font="default" size="100%">Rini Haryati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Giving Red-fleshed Watermelon Juice (Citrullus lanatus (Thunb.)) on Pregnant White Mice (Mus Musculus) Exposed by Monosodium Glutamate (MSG) Orally on the Number and Morphology of Fetus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fetus</style></keyword><keyword><style  face="normal" font="default" size="100%">Infertility</style></keyword><keyword><style  face="normal" font="default" size="100%">Lycopene</style></keyword><keyword><style  face="normal" font="default" size="100%">Monosodium glutamate</style></keyword><keyword><style  face="normal" font="default" size="100%">Red-fleshed watermelon</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">97-102</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Infertility can occur due to the presence of free radicals. One of the most popular of free radical is monosodium glutamate. Free radicals from monosodium glutamate can be prevented by antioxidant compounds. Red-fleshed-fleshed watermelon is a fruit that contains antioxidant compound such as lycopene. &lt;strong&gt;Aim: &lt;/strong&gt;This research was conducted to see the effect of red-fleshed-fleshed watermelon juice on the fetus including number, morphology, visual abnormalities and body weight of pregnant white mice exposed to monosodium glutamate solution orally. Total of 25 female white mice aged around 2-3 months were used as test animals. &lt;strong&gt;Methods: &lt;/strong&gt;Pregnant white mice were divided into 5 test groups. Group I and II served as negative controls (whithout treatment) and positive controls (exposed to monosodium glutamate solution orally at dose of 1g/kgBW). Group III was given a solution of monosodium glutamate orally at dose of 1 g/KgBW added red-fleshed-fleshed watermelon juice at dose of 1.4 g/kgBW. Group IV was given solution of monosodium glutamate orally at dose of 1 g/KgBW added red-fleshed-fleshed watermelon juice at dose of 4.2 g/kgBW. The research data were processed using the one-way ANNOVA test. &lt;strong&gt;Results: &lt;/strong&gt;The result showed that mice body weight, fetal number and morphology (body weight, body length, tail length, and head diameter) did not significantly influence (p&amp;gt;0.05). However, it significantly affected the weight gain of mice during pregnancy. However, it significantly affected the weight gain of mice during pregnancy day 6 to day 17 of pregnancy (p&amp;lt;0.05) and found abnormalities in the fetus such as low birth weight (LBW) and haemorrhage in group II and III. &lt;strong&gt;Conclusion:&lt;/strong&gt; It can be concluded that watermelon juice at dose of 2.8 g/kgBW and 4.2 g/kgBW are effective in ward offfree radicals from monosodium glutamate orally at dose of 1 g/kgBW.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">97</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dwisari Dillasamola, Fitri Rachmaini*, Dian Ayu Juwita, Rini Haryati &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record></records></xml>