<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ranjini HS</style></author><author><style face="normal" font="default" size="100%">Kadmad Abdul Hameed Mohamed Azar</style></author><author><style face="normal" font="default" size="100%">S Fayazul Haq</style></author><author><style face="normal" font="default" size="100%">Prashanthkumar Goudappala</style></author><author><style face="normal" font="default" size="100%">Vinodakumar HR</style></author><author><style face="normal" font="default" size="100%">Akash A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute Oral Toxicity Evaluation of Hydroalcoholic Extract of Salvia Officinalis Roots in Wistar Rats as per OECD 423 TG</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Haematology</style></keyword><keyword><style  face="normal" font="default" size="100%">heart</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Salvia officinalis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">577-582</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;In this study, we assessed the hydroalcoholic root extract of &lt;em&gt;Salvia officinalis &lt;/em&gt;oral acute toxicity investigation using an animal model. &lt;strong&gt;Methods: &lt;/strong&gt;The investigation of acute oral toxicity was conducted using OECD 423 guidelines. The Institutional Animal Ethics Committee approved the study (IAEC). A single oral dose of &lt;em&gt;Salvia officinalis&lt;/em&gt; hydroalcoholic root extract (800, 1600, and 3200 mg/kg) was administered, and the subjects were monitored for 14 days. Animals were sacrificed on the fifteenth day, and body weight, haematological, and serum hepatic biochemical parameters were assessed and compared to the standard group. &lt;strong&gt;Results:&lt;/strong&gt;Groups treated with &lt;em&gt;Salvia officinalis&lt;/em&gt; showed no mortality or discernible alterations. The findings show that Wistar rats did not experience appreciable harmful effects from administering hydroalcoholic root extract from the &lt;em&gt;Salvia officinalis&lt;/em&gt; plant. &lt;strong&gt;Conclusions:&lt;/strong&gt; The extract can be utilized safely for therapeutic use in pharmaceutical formulations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">577</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ranjini HS&lt;sup&gt;1&lt;/sup&gt;, Kadmad Abdul Hameed Mohamed Azar&lt;sup&gt;2&lt;/sup&gt;, S Fayazul Haq&lt;sup&gt;3&lt;/sup&gt;, Prashanthkumar Goudappala&lt;sup&gt;4*&lt;/sup&gt;, Vinodakumar H R&lt;sup&gt;5&lt;/sup&gt;, Akash&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Assistant professor, Department of Biochemistry, BGSMCH, Nagarur, Bengaluru North, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Pharmacology, Srinivas Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, INDIA .&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Biochemistry, Sri Siddhartha Institute of Medical Sciences, Sri Siddhartha Academy of Higher Education, T Begur, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Associate Professor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Assistant Professor, 6Tutor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amr A. Fouad</style></author><author><style face="normal" font="default" size="100%">Moataz Mohamedalhasan Ali</style></author><author><style face="normal" font="default" size="100%">Mostafa Abdel-Hamid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Punicalagin Opposes Gentamicin Nephrotoxicity in Rats: Role of Nrf2 and NF-κB Pathways</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gentamicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Punicalagin</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">126-130</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Oxidative stress, inflammation, and apoptosis are implicated in gentamicin (GEN)-induced nephrotoxicity. Punicalagin (PNG) possesses antioxidant, anti-inflammatory, and antiapoptotic effects. Objective: The aim of the present research was to investigate the possible defensive effect of PNG against nephrotoxicity caused by GEN in male Sprague-Dawley rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; GEN (80 mg/kg/day, i.p.) was administered for 8 days. Treatment with PNG (25 mg/kg/day, p.o.) for 10 days, began 2 days before GEN insult. &lt;strong&gt;Results: &lt;/strong&gt;PNG significantly decreased serum creatinine, and malondialdehyde, tumor necrosis factor-α, interleukin-6, inducible nitric oxide synthase, nuclear factor-κB p65 (NF- κB p65), and cleaved caspase-3 activity in the kidneys of GEN-challenged rats. PNG also significantly increased renal catalase, reduced glutathione, and nuclear factor erythroid 2-related factor 2 (Nrf2) in rats received GEN. Additionally, PNG markedly attenuated the histopathological kidney tissue injury caused by GEN. &lt;strong&gt;Conclusion: &lt;/strong&gt;PNG guarded against GEN-induced kidney damage in rats through its antioxidant, anti-inflammatory, and antiapoptotic effects, and by modulating the balance between Nrf2 and NF-κB pathways.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">126</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amr A. Fouad&lt;sup&gt;1,&lt;/sup&gt;*, Moataz Mohamedalhasan Ali&lt;sup&gt;2&lt;/sup&gt;, Mostafa Abdel-Hamid&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Al-Baha University, Al-Baha, SAUDI ARABIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pathology, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia &amp;amp; Department of Pathology, Faculty of Medicine, University of Elimam Elmahdi, SUDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anatomy and Embryology, Faculty of Medicine, Al-Baha University, Al- Baha, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Paulus Anthony Halim</style></author><author><style face="normal" font="default" size="100%">Wachid Putranto</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Omega-3 Rich Fish Oil on the Kidney Changes in Mice Induced by Azoxymethane and Dextran Sodium Sulfate</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Azoxymethane</style></keyword><keyword><style  face="normal" font="default" size="100%">Dextran sodium sulfate</style></keyword><keyword><style  face="normal" font="default" size="100%">Fish oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Omega-3</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">259-266</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: The study aimed to investigate the effect of omega-3 rich fish oil to kidney of mice induced by Azoxymethane (AOM) and DSS using histopathology parameters. &lt;strong&gt;Method:&lt;/strong&gt; The experimental mice were induced using 10 mg/kg AOM and 2% DSS for 2 weeks randomly allocated randomly into four groups as follows;&lt;strong&gt; Control Group:&lt;/strong&gt; mice that not received fish oil, Low Dose Group: mice that received 1.5 mg/day fish oil, Medium Dose Group: mice that received 3 mg/day fish oil, and High Dose Group: mice that received 6 mg/day fish oil. The omega-3 rich fish oil was given for 12 weeks. &lt;strong&gt;Result:&lt;/strong&gt; The administration of high dose omega-3 rich fish oil was able to reduced necrosis and inflammation foci compared to the control group (p&amp;lt;0.05). Furthermore, the administration of low, medium, and high dose omega-3 rich fish oil was able to significantly reduced vascular edema and cell degeneration foci (p&amp;lt;0.05). The administration of medium and high dose of omega-3 rich fish oil were able to reduce the amount of fibrosis foci compared to the control group (p&amp;lt;0.05) compared to the control group. &lt;strong&gt;Conclusion: &lt;/strong&gt;The result suggested anti-nephrotoxic effect of omega-3 rich fish oil in mice induced by azoxymethane and DSS.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">02</style></accession-num><section><style face="normal" font="default" size="100%">259</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Paulus Anthony Halim&lt;sup&gt;3&lt;/sup&gt;, Wachid Putranto&lt;sup&gt;4,*&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2,5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Doctoral Programme Study of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Drug Development Research Cluster, Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Jakarta, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Nephrology, Department of Internal Medicine, Dr. Moewardi General Hospital, Faculty of Medicine, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afriwardi</style></author><author><style face="normal" font="default" size="100%">Rahmad Abdillah</style></author><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Hafifah Hardini</style></author><author><style face="normal" font="default" size="100%">Khalila Tri Syahbani Zuler</style></author><author><style face="normal" font="default" size="100%">Aditya Alqamal Alianta</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Subacute Toxicity Test of Hydrocotyle Sibthorpioides Lam. Extract on Histopathological Images of Liver and Kidney of White Male Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrocotyle sibthorpioides Lam.</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">LD50</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Subacute.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">619-626</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Hydrocotyle sibthorpioides&lt;/em&gt; Lam. in Indonesia known as pegagan embun. It has been used to increase the immune system and has been shown to have immunostimulating, anti-inflammatory and hematopoietic effects. However, there is no scientific evidence that shows this plant is safe for long-term use. Based on that circumstance, this study aimed to measure the safety of Pegagan Embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam.) ethanol extract activities on liver and kidney histopathology. &lt;strong&gt;Aim:&lt;/strong&gt; The study aimed to measure the safety of Pegagan Embun (&lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;Lam.) ethanol extract activities on liver and kidney histopathology. &lt;strong&gt;Material and Method&lt;/strong&gt;: Ethanol extract used because all the active compounds in plants extracted as a whole, and it cheaper and more efficient in the extraction process. Determine as many thirty-six white male mice as test animals and separate them into eight treatment groups. The administrated ethanol extract of Pegagan Embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam.) at doses of 7, 35, and 150 mg/kg BW for 7, 14, and 21 days. On days 8&lt;sup&gt;th&lt;/sup&gt;, 15&lt;sup&gt;th&lt;/sup&gt;, and 22&lt;sup&gt;nd&lt;/sup&gt;, three white male mice collected from each treatment group and collected their liver and kidney. The data analysed used a T-test with IBM SPSS type 24. &lt;strong&gt;Result: &lt;/strong&gt;LD50 of ethanol extract of &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. &amp;gt; 15,000 mg/kg means practically not toxic. The results showed that the administration of extract &lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;Lam. for 7, 14, and 21 days showed a non-significant effect on any histological damage to the liver of male white mice at doses of 7 and 35 mg/kg BW (normal histology). The non-significant effect also occurs at150 mg/kg BW for 7 days; however, it caused mild damage at a dose of 150 mg/kg BW for 14 days and moderate damage at 150 mg/kg BW for 21 days. In renal histopathology, doses of 7 mg/kg BW. for 7, 14, and 21 days showed normal histology and doses of 35 mg/kg BW for 7, 14, and 21 days showed minimal damage. The administration at doses of 150 mg/kg BW for 7 days showed mild damage, while a dose of 150 mg/kg BW for 14 and 21 days showed moderate damage. &lt;strong&gt;Conclusion:&lt;/strong&gt; It concluded that the administration of extract of &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. did not cause severe damage to the histology of the liver and kidneys of white male mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">619</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Afriwardi&lt;sup&gt;1&lt;/sup&gt;, Rahmad Abdillah&lt;sup&gt;2&lt;/sup&gt;, Elidahanum Husni&lt;sup&gt;3&lt;/sup&gt;, Hafifah Hardini&lt;sup&gt;4&lt;/sup&gt;, Khalila Tri Syahbani Zuler&lt;sup&gt;4&lt;/sup&gt;, Aditya Alqamal Alianta&lt;sup&gt;5&lt;/sup&gt;, Yufri Aldi&lt;sup&gt;6,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;lecturer in the Department of Physiology also as the Dean of Faculty of Medicine Universitas Andalas, Dean at the Faculty of Dentistry of Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;lecturer in Department of Pharmacology, Faculty of Pharmacy, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;lecturer in Department of Biology of Pharmacy, Faculty of Pharmacy, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Profession student in Pharmacist Program at Faculty of Pharmacy, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;lecturer in Department on Socio-economic Animal Science, Faculty of Animal Science, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;lecturer in Department of Pharmacology, Faculty of Pharmacy, Universitas Andalas, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Ema Dewanti</style></author><author><style face="normal" font="default" size="100%">Cut Mauliza</style></author><author><style face="normal" font="default" size="100%">Ester Hidayati</style></author><author><style face="normal" font="default" size="100%">Ita Anggraini</style></author><author><style face="normal" font="default" size="100%">Riska Anggraini</style></author><author><style face="normal" font="default" size="100%">Vera Ladeska</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Acute Toxicity of Ki Hampelas Leaves (Sterculia rubiginosa Zoll. Ex Miq)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Ki Hampelas ( Sterculia rubiginosa Zoll. Ex Miq)</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">570-576</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ki Hampelas (&lt;em&gt;Sterculia rubiginosa&lt;/em&gt; Zoll. Ex Miq) is a medicinal plant with antioxidant and nephroprotective activity. &lt;strong&gt;Objective:&lt;/strong&gt; This research aims to prove that Ki Hampelas leaves extract through an acute toxicity test. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;This study used white male rats of the&lt;em&gt; Sprague-Dawley&lt;/em&gt; strain divided into four groups, the normal group and the 50 mg/ kg, 1000 mg/kg, 2000 mg/kg dose groups. For the acute toxicity test, a single dose with an observation of 14 days. After that, the surgery was done to see changes in the histopathology of the liver and kidneys. &lt;strong&gt;Results: &lt;/strong&gt;The administration of Ki Hampelas leaf extract in the acute toxicity test did not cause death in the tested animals. There were no significant liver and kidney changes seen from the SGOT, SGPT, creatinine, urea, and histopathology. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ki Hampelas leaves extract did not cause death and toxic effects in the acute toxicity test.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">570</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rini Prastiwi*, Ema Dewanti, Cut Mauliza, Ester Hidayati, Ita Anggraini, Riska Anggraini, Vera Ladeska&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;University of Mu- hammadiyah Prof. Dr. Hamka, Klender, Jakarta 13460, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Revathi B</style></author><author><style face="normal" font="default" size="100%">Lakshmanan S</style></author><author><style face="normal" font="default" size="100%">Veerakumar D</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Impact of Insecticide, Chlorpyrifos on Protein and Amino Acid Contents in Liver, Kidney and Brain of Exotic Teleost Fish, Channa punctatus (Bloch, 1973)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biochemical constituents</style></keyword><keyword><style  face="normal" font="default" size="100%">Brain</style></keyword><keyword><style  face="normal" font="default" size="100%">Channa punctatus</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorpyrifos</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">351-355</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Pesticides are one of the most potentially harmful toxic chemicals introduced into the environment and human ambient. These pesticides are utilized widely to ensure agricultural harvests against the harm brought about by different sorts of irritations. Anyway, these chemicals may reach non focused on biological systems like lakes and waterways through rain and wind, influencing numerous different organisms. Biochemical factors show explicit reactions to specific types of ecological pressure. The methodology of present work was to assess toxic effects of an insecticide, chlorpyrifos on biochemical constituents like protein, and Amino acid in liver, kidney and Brain of freshwater fish, &lt;em&gt;Channa punctatus&lt;/em&gt;. The fish exposed to chlorpyrifos showed a decrease the protein and increase the amino acid levels for 15 and 45 days in liver, kidney and brain compared to control. The objectives of the present work was to observe the effect of chlorpyrifos on protein and amino acid levels in the liver, kidney and brain of teleost fish &lt;em&gt;Channa punctatus&lt;/em&gt;.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">351</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Revathi B&lt;sup&gt;1&lt;/sup&gt;, Lakshmanan S&lt;sup&gt;2,&lt;/sup&gt;*, Veerakumar D&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Ph.D, Research Scholar, Department of Zoology, Poompuhar College (Autonomous), Melaiyur – 609 107, Sirkali Taluk, Nagapattinam, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Zoology, Poompuhar College (Autonomous), Melaiyur – 609 107, Sirkali Taluk, Nagapattinam, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Ph.D, Research Scholar, Department of Zoology, Annamalai University, Annamalai Nagar- 608 002, Tamilnadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tanuja Singh</style></author><author><style face="normal" font="default" size="100%">Ruchi</style></author><author><style face="normal" font="default" size="100%">Anjali singh</style></author><author><style face="normal" font="default" size="100%">Ravish Kumar</style></author><author><style face="normal" font="default" size="100%">Jitendra Kumar Singh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute toxicity study of Phyllanthus niruri and its effect on the cyto-architectural structure of nephrocytes in Swiss albino mice Mus-musculus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Histological analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">LD50</style></keyword><keyword><style  face="normal" font="default" size="100%">P. niruri.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">77-80</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; In the era of herbal renaissance, world is moving towards the medicinal plant that repairs and strengthening the body system without any toxic side effects. Popular medicinal plant &lt;em&gt;Phyllanthus niruri&lt;/em&gt; contains various bioactive molecules, the present study aimed to observe the biochemical and cyto-architectural alterations in kidney associated with acute oral toxicity (LD&lt;sub&gt;50&lt;/sub&gt;) of aqueous extract of &lt;em&gt;P.niruri&lt;/em&gt; in Swiss albino mice. However, limited data is available about the toxicity of herbal remedies used for medication, which is a critical constrain. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; For the acute oral toxicity study, the animals were divided into six groups of 6 mice each. Group&amp;ndash;I was named control group and the treatment groups were administered aqueous leaf extract of &lt;em&gt;P.niruri&lt;/em&gt; orally at different doses of 500 mg/Kg bw (Group-II), 1000 mg/Kg bw (Group-III), 2000 mg/Kg bw (Group-IV), 2500 mg/Kg bw (Group-V) and 3000 mg/Kg bw (Group-VI) for 15 consecutive days. The mice were sacrificed on and serum was collected for the biochemical analysis. The kidney was dissected and processed for histological analysis. &lt;strong&gt;Results:&lt;/strong&gt; The LD&lt;sub&gt;50&lt;/sub&gt; dose of &lt;em&gt;P.niruri &lt;/em&gt;was found to be 2590.984 mg/Kg bw in Swiss albino mice model in laboratory condition. The result showed the elevated serum level of urea in treated group of mice at higher doses which was found to be statistically significant as compared to the control (Group&amp;ndash;I). There were no any significant increase in serum creatinine has been observed. Histological alteration were observed at higher dose more than 2500 mg/Kg bw (Group-VI). &lt;strong&gt;Conclusion:&lt;/strong&gt; It is evident from our study that &lt;em&gt;P. niruri &lt;/em&gt;may have toxic effect at high doses. Therefore, it should be ingested with precautions.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">77</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Tanuja Singh&lt;sup&gt;1&lt;/sup&gt;, Ruchi&lt;sup&gt;2&lt;/sup&gt;, Anjali Singh&lt;sup&gt;3&lt;/sup&gt;, Ravish Kumar&lt;sup&gt;3&lt;/sup&gt; and Jitendra Kumar Singh&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Botany, Thakur Prasad Singh, College, Magadh University, Patna.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, Braj Mohan Das College, Dayalpur, Babasaheb Bhimrao Ambedkar, Bihar University, Bihar, India&amp;ndash;844502.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Centre, Mahavir Cancer Sansthan, Phulwarisharif, Patna, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Research, S.S. Hospital and Research Institute, Patna, India.&lt;/p&gt;</style></auth-address></record></records></xml>