<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sri Hidanah</style></author><author><style face="normal" font="default" size="100%">Emy Koestanti Sabdoningrum</style></author><author><style face="normal" font="default" size="100%">Sri Agus Sudjarwo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Formulation and Characterization of Meniran (Phyllanthus Niruri Linn) Extract Nanoparticle on Antibacterial Activity Against Salmonella Pullorum</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri</style></keyword><keyword><style  face="normal" font="default" size="100%">Salmonella Pullorum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">369-373</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aims to examine the results of meniran extract (&lt;em&gt;Phyllanthus niruri Linn.&lt;/em&gt;) on antibacterial activity. &lt;em&gt;Salmonella Pullorum&lt;/em&gt; is capable of causing huge economic losses. The misuse of antimicrobials has resulted in the evolution of multidrug-resistant strains. Meniran has potential as an antibacterial because it contains many bioactive components such as alkaloids, flavonoids, tannins and saponins. Nanoparticles help in the bioavailability of plant extracts. The research was conducted by making a meniran extract nanoparticles formulation with ionic glass method using chitosan and TPP sodium with a dose difference of 5%, 10% and 20%. Each dose of meniran nanoparticles then were characterized by PSA, SEM and TEM. The result on PSA showed that size range from 192.67 nm to 385.16 nm and 5% meniran extract nanoparticles have the best homogeneity and stability. EE value showed that the increase in the dose was directly proportional to the increase in the EE value. The result on SEM showed that the overall production of nanoparticle samples, it looks like they are nano-sized. The result on TEM showed small sample morphology with a good distribution. After that, the antibacterial activity test was then carried out using the MIC and MBC tests. The results showed that 5% of meniran extract nanoparticles had the best antibacterial activity against Salmonella Pullorum.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">369</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sri Hidanah, Emy Koestanti Sabdoningrum*, Sri Agus Sudjarwo&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Emy Koestanti Sabdoningrum</style></author><author><style face="normal" font="default" size="100%">Sri Hidanah</style></author><author><style face="normal" font="default" size="100%">Sri Chusniati</style></author><author><style face="normal" font="default" size="100%">Soeharsono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Characterization and Phytochemical Screening of Meniran (Phyllanthus niruri Linn) Extract's Nanoparticles Used Ball Mill Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biological production</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical compound</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1568-1572</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The aim of this study was to study the characterization and phytochemical screening of meniran (&lt;em&gt;Phyllanthus niruri&lt;/em&gt; linn) extract's nanoparticles used ball mill method. The effect of herbal products would be maximized, a formulation that able to increase solubility, stability, bioavailability, and a targeted system was needed so the use of simplicia would be more effective. One of alternative solutions to this problem was to make the preparation of meniran extract in the form of nanoparticles. Nanoparticles made it easier for extract to be absorbed in blood plasma and were more effective in achieving the target drug itself. The manufacture of meniran nanoparticles used ball mill method. Then, meniran extract nanoparticles characterization and phytochemical screening were carried out. Meniran (&lt;em&gt;Phyllanthus niruri&lt;/em&gt; Linn) extract nanoparticle characterization consisted of size, used Particle Size Analyzer (PSA), and morphology, used Scaning Electron Microscope (SEM). Phytochemical screening of meniran extract nanoparticles used qualitative screening by reagent test. The results showed that the meniran extract nanoparticles produced an average size of 192.6 nm. The averange shape of particle was imperfectly amorphous and the dominant composition was Carbon (C). Phytochemical screening showed the content of flavonoids, tannins, saponins, terpenoids and alkaloids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1568</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Emy Koestanti Sabdoningrum&lt;sup&gt;*&lt;/sup&gt;, Sri Hidanah, Sri Chusniati, Soeharsono&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tutik Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Adita Ayu Permanasari</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Hak Hotta</style></author><author><style face="normal" font="default" size="100%">Chie Aoki-Utsubo</style></author><author><style face="normal" font="default" size="100%">Achmad Fuad Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiviral Activity of Indonesian Medicinal Plants against Hepatitis B Virus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Curcuma xanthorhiza</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis B Virus</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1108-1114</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Hepatitis B virus (HBV) infects more than 300 million people globally and is a common cause of liver cancer. Current therapy using reverse transcriptase inhibitors require long-term treatment and the potential risk of development of drug-resistant viruses remains an important issue to be considered. Hence, the development of new drugs is critical. Traditional medicinal plants used for the treatment of infectious diseases may provide a viable option for the discovery of anti-HBV drug candidates. &lt;strong&gt;Objective: &lt;/strong&gt;This study examined anti-HBV activity of 31 kinds of Indonesian plants. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Crude extracts of various part of plants, leaves and stem, were obtained using dichloromethane and ethanol solvent. The effect on viral entry was examined by determining levels of HBsAg expression in the supernatants of HBV-infected HepG2-NTCP cells by ELISA. The effect on HBV replication was determined by measuring HBV DNAs amounts in Hep38.7-Tet cells by quantitative real-time PCR.&lt;strong&gt; Results: &lt;/strong&gt;The extracts of &lt;em&gt;Phyllantus niruri&lt;/em&gt; leaves and &lt;em&gt;Curcuma xanthorrhiza &lt;/em&gt;showed reduction of strong HBsAg production from HepG2-NTCP cells with IC&lt;sub&gt;50&lt;/sub&gt; values of 170.48 and 270.51 μg/mL, respectively. Treatment of HepAD38.7-Tet cells with &lt;em&gt;P. niruri &lt;/em&gt;and &lt;em&gt;C. xanthorhiza &lt;/em&gt;at the highest concentration while avoiding cytotoxicity reduced extracellular HBV DNA levels by 70% and 30 % of the untreated control respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;&lt;em&gt;P. niruri &lt;/em&gt;inhibited both the entry and HBV replication, thus &lt;em&gt;P. niruri &lt;/em&gt;is a promising candidate for anti-HBV drug development.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1108</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tutik Sri Wahyuni&lt;sup&gt;1,2,&lt;/sup&gt;*, Adita Ayu Permanasari&lt;sup&gt;2&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;1,2,&lt;/sup&gt; Hak Hotta&lt;sup&gt;3,4&lt;/sup&gt;, Chie Aoki-Utsubo&lt;sup&gt;4&lt;/sup&gt;, Achmad Fuad Hafid&lt;sup&gt;1,2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Jl. Mulyorejo, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of Tropical Disease, Universitas Airlangga, Jl. Mulyorejo, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Clinical Nutrition and Dietetics, Konan Women’s University, 6-2-23 Morikitamachi, Higashinada-ku, Kobe 658-0001, JAPAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Public Health, Kobe University Graduate School of Health Sciences, 7-10-2, Tomogaoka, Suma-ku, Kobe 654-0142, JAPAN.&lt;/p&gt;
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