<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sarra Abbad</style></author><author><style face="normal" font="default" size="100%">Nadia Aissaoui</style></author><author><style face="normal" font="default" size="100%">Fatima Zahra Gana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Marrubium vulgare Leaf Extract-Assisted Green Synthesis of Silver Nanoparticles: Optimization, Characterization and In Vitro Exploration of Their Antimicrobial, Antioxidant and Anti- Inflammatory Potential</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biological activities</style></keyword><keyword><style  face="normal" font="default" size="100%">Characterization</style></keyword><keyword><style  face="normal" font="default" size="100%">Green synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Marrubium vulgare</style></keyword><keyword><style  face="normal" font="default" size="100%">Silver nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">7-21</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Biogenic metal nanoparticles are gaining popularity due to their remarkable biomedical properties, which provide hope in the fight against various diseases. &lt;strong&gt;Objective: &lt;/strong&gt;This research produced silver nanoparticles (AgNPs) from an aqueous extract of &lt;em&gt;Marrubium vulgare &lt;/em&gt;leaves by a simple, onestep, bottom-up green route. For the first time in the literature, the antimicrobial, antioxidant, and antiinflammatory potentials of AgNPs obtained using leaves of &lt;em&gt;Marrubium vulgare&lt;/em&gt; are investigated. &lt;strong&gt;Methods and results:&lt;/strong&gt; The optimal conditions for biosynthesis were 80 °C reaction temperature, 60 min incubation time, 2 mM AgNO&lt;sub&gt;3&lt;/sub&gt;, and 100 μL extract volume. The FTIR results indicated that the distinct functional groups found in M. vulgare extract were also present in AgNPs, confirming their critical role in silver bioreduction and AgNP capping. The biosynthesized AgNPs were crystalline, with face-centered cubic geometry, according to XRD analysis. DLS analysis asserted that the constructed AgNP's average size was 34.58 nm, whereas SEM/TEM revealed their spherical morphology. The AgNPs produced through biosynthesis inhibited microbial proliferation in a dose-dependent manner. They exhibited bactericidal attributes against both Gram-negative and Gram-positive bacteria, with MIC values ranging from 0.041 to 5.312 μg/mL and MBCs from 0.083 to 5.312 μg/mL. Furthermore, the AgNPs exhibited fungicidal activity against three &lt;em&gt;Candida albicans &lt;/em&gt;strains, with MIC and MFC respective values recorded at 2.656 and 2.656-5.312 μg/mL. Additionally, the biosynthesized AgNPs demonstrated significant antioxidant potency compared to ascorbic acid and the extract. Their potent in vitro anti-inflammatory effect, attributed to the inhibition of BSA denaturation, was directly proportional to the AgNP concentration, with a maximum inhibition of 86.14% observed at 200 μg/mL. &lt;strong&gt;Conclusion: &lt;/strong&gt;Therefore, the findings suggest that AgNPs have promising applications in combating the growing threat of antimicrobial resistance and might be utilized as potent antioxidant and anti-inflammatory agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">7</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sarra Abbad&lt;sup&gt;1*&lt;/sup&gt;, Nadia Aissaoui&lt;sup&gt;2&lt;/sup&gt;, Fatima Zahra Gana&lt;sup&gt;1,3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine, Abou Bekr Belkaid University, Tlemcen 13000, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Sustainable Management of Natural Resources in Arid and Semi-arid Areas, University Center of Naama, Naama 45000, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Analytical Chemistry and Electrochemistry, Abou Bekr Belkaid University, Tlemcen 13000, ALGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pallab Kar</style></author><author><style face="normal" font="default" size="100%">Ayodeji O. Oriola</style></author><author><style face="normal" font="default" size="100%">Moganavelli Singh</style></author><author><style face="normal" font="default" size="100%">Adebola O. Oyedeji</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Myricitrin-Mediated Biogenic Silver Nanoparticle Synthesis, Characterization, and its Antioxidant, Anticancer, and DNA Cleavage Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA cleavage</style></keyword><keyword><style  face="normal" font="default" size="100%">Myricitrin</style></keyword><keyword><style  face="normal" font="default" size="100%">Silver nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">121-128</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Myricitrin (MY) is a potent antioxidant flavonoid that has recently gained research interest due to its wide applications in food, cosmetics, and medicine. &lt;strong&gt;Objective: &lt;/strong&gt;The current work reports MY, its isolation and characterization from &lt;em&gt;Eugenia uniflora&lt;/em&gt; leaves, and green synthesis with AgNO&lt;sub&gt;3&lt;/sub&gt; to afford myricitrin-based silver nanoparticles (MY-Ag NPs). &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The biosynthesized nanoparticles (NPs) were characterized using UV, field emission scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), High-resolution transmission electron microscopy (HRTEM) and Dynamic light scattering (DLS) methods. Antioxidant, anti-cancer, and DNA cleavage activities were based on standard&lt;em&gt; in vitro &lt;/em&gt;bioassay methods. &lt;strong&gt;Results: &lt;/strong&gt;The UV-vis absorption peak at 430 nm suggests the formation of silver-based NPs. The FESEM imaging showed spherical-to-cubical shaped MY-Ag NPs with an average size of 45.35 nm. The EDX analysis showed the presence of elemental Ag (89.40%) and N (10.22%), suggesting a successful synthesis. The XRD analysis revealed various peaks at 38.37⁰, 43.56⁰, 63.76⁰, and 77.77⁰, which suggest metallic silver reflections, further establishing the crystallinity of NPs. The MY-Ag NPs inhibited O&lt;sub&gt;2&lt;/sub&gt; -, OH-, H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;, and NO free radicals in a dose-dependent manner. At 50 and 80 μg/mL, it demonstrated a better inhibitory effect on OH- radical than &lt;em&gt;L&lt;/em&gt;-ascorbic acid. The cytotoxicity (IC&lt;sub&gt;50&lt;/sub&gt;) against human cancer cell lines of the kidney (ACHN) and the liver (HepG2) were 54.21 ± 0.06 μg/mL and 33.36 ± 2.25 μg/mL respectively at 48 h post-treatment. Lastly, at 20 mg/mL for 120 minutes, MY-Ag NPs cleaved DNA, acting as chemical nucleases. This may suggest its capacity to impede cancer cells by cleaving the genome. &lt;strong&gt;Conclusion: &lt;/strong&gt;Therefore, this study has shown that Myricitrinbased Ag NPs possess notable antioxidant and cytotoxicity that can be further exploited in the search for newer anticancer agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">121</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pallab Kar&lt;sup&gt;1&lt;/sup&gt;, Ayodeji O. Oriola&lt;sup&gt;2,*&lt;/sup&gt;, Moganavelli Singh&lt;sup&gt;3&lt;/sup&gt;, Adebola O. Oyedeji&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;African Medicinal Flora and Fauna Research Niche Area, Walter Sisulu University Nelson Mandela Drive, P/Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemical and Physical Sciences, Walter Sisulu University, Nelson Mandela Drive, P/ Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Nano-Gene and Drug Delivery Group, Discipline of Biochemistry, University of KwaZulu-Natal, Private Bag, Durban X54001, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ayodeji O. Oriola</style></author><author><style face="normal" font="default" size="100%">Pallab Kar</style></author><author><style face="normal" font="default" size="100%">Adebola O. Oyedeji</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis and Characterization of Biogenic Silver Nanoparticles using Medicinally important Nigella sativa L. (black Cumin) and their Antioxidant, Anti‑inflammatory, and DNA Cleavage Potentials</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA cleavage</style></keyword><keyword><style  face="normal" font="default" size="100%">Nigella sativa</style></keyword><keyword><style  face="normal" font="default" size="100%">Silver nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">282-288</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The application of nanotechnology in herbal medicine offers promising prospects for drug delivery by enabling targeted, controlled, and efficient delivery of medicinal ingredients, potentially minimizing side effects and improving treatment outcomes. Nigella sativa L. (black Cumin) seed infusions are useful in Asian and African ethnomedicines in remedying stress and inflammatory-related ailments. &lt;strong&gt;Objective: &lt;/strong&gt;On this premise, black Cumin-based silver nanoparticles (BC-Ag NP) were developed and evaluated for their biological potential. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Silver nanoparticles (AgNPs) were green synthesized using the seed aqueous extract of black cumin (BC). The BC-AgNPs were characterized using scanning electron microscopy (SEM), field emission scanning electron microscopy (FESEM), highresolution transmission electron microscopy analysis (HRTEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD). The biological potential of the NPs was based on NO, H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;, •OH, and O&lt;sub&gt;2&lt;/sub&gt; •– radical scavenging antioxidant, egg albumin denaturation (anti-inflammatory), and DNA cleavage assay methods.&lt;strong&gt; Results: &lt;/strong&gt;The SEM and FESEM revealed spherical-to-cubical-shaped ultrafine BC-Ag NPs with a size of less than 100 nm. The HR-TEM micrograph confirmed each NP to be spherical in shape and within the 10-50 nm range. The X-ray diffractogram showed the crystallinity of the NPs with a sharp peak at 38.12° [reflection index (111)] at an average size of 47 nm. The transformation of metallic silver into elemental silver was validated by EDX analysis, with 97.58% elemental Ag at ~3 keV acute curve. The BC-Ag NPs showed dose-dependent antioxidant activity, with IC50 of 87.56 ± 1.54 and 110.5 ± 2.27 μg/mL against H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; and O&lt;sub&gt;2&lt;/sub&gt; ._ free radicals, respectively. The anti-inflammatory activity of the NPs was one-third the potency of Diclofenac sodium (standard drug) at IC&lt;sub&gt;50&lt;/sub&gt; of 103.44 ± 5.35 μg/mL. Finally, the BC-Ag NPs acted as chemical nucleases to cleave DNA at a 20 mg/mL concentration for 120 minutes.&lt;strong&gt; Conclusion: &lt;/strong&gt;This study has shown that AgNPs biosynthesized with black Cumin seed extract possess notable antioxidant, anti-inflammatory, and DNA cleavage properties and, thus, may be a useful nanomaterial for efficient pharmaceutical delivery.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">282</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ayodeji O. Oriola&lt;sup&gt;1,*&lt;/sup&gt;, Pallab Kar&lt;sup&gt;2,*&lt;/sup&gt;, Adebola O. Oyedeji&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemical and Physical Sciences, Walter Sisulu University, Nelson Mandela Drive, P/ Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;African Medicinal Flora and Fauna Research Niche Area, Walter Sisulu University Nelson Mandela Drive, P/Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sheik Shehensha</style></author><author><style face="normal" font="default" size="100%">M Vijaya Jyothi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory Activity of Nigella sativa oil Mediated Silver Nanoparticles</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti- Inflammatory effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Nigella sativa</style></keyword><keyword><style  face="normal" font="default" size="100%">Rananculaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">SEM analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Silver nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1086-1092</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The aim of the study was to employ &lt;em&gt;Nigella sativa&lt;/em&gt; oil in the synthesis of silver nanoparticles and to assess the anti-inflammatory activity of the&lt;em&gt; Nigella sativa &lt;/em&gt;oil mediated silver nanoparticles. &lt;strong&gt;Background:&lt;/strong&gt; The introduction of Nanoparticles (NPs) has transFigured many fields like medicine, nutrition and electronics. The usage of nanotechnology in medicine particularly for drug delivery is revealed to have numerous benefits. Nanoparticles are being used to decrease toxicity and side effects that drugs may impose to the patient. &lt;em&gt;Nigella sativa&lt;/em&gt; is considered as a miracle seed. It has been reported to have anti-inflammatory, diuretic, and antihypertensive activity. Plant mediated biological synthesis of nanoparticles is simple and eco-friendly method. This work therefore was aimed to synthesize &lt;em&gt;Nigella sativa&lt;/em&gt; oil mediated silver nanoparticles and evaluate its anti-inflammatory activity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; &lt;em&gt;Nigella sativa&lt;/em&gt; oil mediated silver nanoparticles were synthesised by short term (1 day) interaction of &lt;em&gt;Nigella sativa&lt;/em&gt; seed extract (1 ml) with 2mM AgNO&lt;sub&gt;3&lt;/sub&gt; solution and centrifuged to obtain silver nanoparticles. The nanoparticles were characterised by UV-Visible spectrophotometer, FTIR and Scanning Electron Microscopy (SEM). Further the oil mediated AgNPs were evaluated for anti-inflammatory activity by &lt;em&gt;in vitro&lt;/em&gt; and&lt;em&gt; in vivo &lt;/em&gt;methods. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;Nigella sativa&lt;/em&gt; oil mediated AgNPs were biofabricated with ease and exhibited good anti-inflammatory activity compared to standard. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study concludes that &lt;em&gt;Nigella sativa&lt;/em&gt; seed oil mediated silver nanoparticles have the potential to be used as an effective antioxidant. Hence, it may be used in many medicinal applications to treat inflammation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1086</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sheik Shehensha&lt;sup&gt;1,&lt;/sup&gt;*, M.Vijaya Jyothi&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Pharmaceutical Sciences, Jawaharlal Nehru Technological University Anantapur, Anantapuramu. Andhra Pradesh, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor, Department of Pharm. Chemistry, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu, Andhra Pradesh, INDIA.&lt;/p&gt;
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