<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Justil-Guerrero Hugo Jesús</style></author><author><style face="normal" font="default" size="100%">Chávez-Flores Juana Elvira</style></author><author><style face="normal" font="default" size="100%">Cárdenas-Orihuela Robert Armando</style></author><author><style face="normal" font="default" size="100%">Ramos- Jaco Antonio Guillermo</style></author><author><style face="normal" font="default" size="100%">Ñañez-del-Pino Daniel</style></author><author><style face="normal" font="default" size="100%">Vásquez-Quispe Ángel David</style></author><author><style face="normal" font="default" size="100%">Rojas-Cardenas Nathalie Felicita</style></author><author><style face="normal" font="default" size="100%">Fernández-Flores Nélber</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Capacity and Protective Effect of Aqueous and Hydroalcoholic Extracts of Senecio rhizomatus Rusby &quot;Llancahuasi&quot; on Erythrocytes Subjected to Oxidative Stress</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoperoxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasma membrane redox system</style></keyword><keyword><style  face="normal" font="default" size="100%">Reactive Oxygen Species</style></keyword><keyword><style  face="normal" font="default" size="100%">Reduced glutathione</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">516-527</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective. &lt;/strong&gt;To evaluate the antioxidant capacity and protective effect of aqueous and hydroalcoholic extracts of &lt;em&gt;Senecio rhizomatus&lt;/em&gt; Rusby in rat erythrocytes subjected to oxidative stress with hydrogen peroxide (H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;). &lt;strong&gt;Methodology.&lt;/strong&gt; This study used an experimental design. The extracts were obtained through maceration with 96° ethanol (SeR96), 70° ethanol (SeR70), 50° ethanol (SeR50) and through infused water (SeRAc). Secondary metabolites were identified through colorimetric reactions and precipitation. In each extract, we could determine the capacity to eliminate 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), the reduction of ferric ion and the total polyphenol content. In addition, the activity on the plasma membrane redox system (PMRS) was evaluated in each extract. The protection against oxidative stress in erythrocytes was evaluated by determining the content of reduced glutathione (GSH) and malondialdehyde (MDA). &lt;strong&gt;Results.&lt;/strong&gt; Alkaloids, flavonoids, phenolic compounds, sesquiterpene lactones and sugars were identified in all the extracts. The total polyphenols content showed a correlation with the reduction of ferric ion (r=0.885) and with DPPH radicals elimination (r = -0.899), where the one with the highest antioxidant capacity was SeR50. Thus, the SeR50 (all concentrations) and SeR70 (100 μg/mL concentration) significantly increased the PMRS activity compared to the control group. After inducing oxidative stress in erythrocytes, all the extracts maintained the GSH level and inhibited MDA formation significantly compared to the H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; group. &lt;strong&gt;Conclusion.&lt;/strong&gt; The antioxidant capacity of hydroalcoholic extracts (96°, 70°, 50°) and aqueous infusion of &lt;em&gt;Senecio rhizomatus &lt;/em&gt;Rusby is related to the content of polyphenols. They increase the plasma membrane redox system activity in rat erythrocytes and protect them from oxidative stress induced with H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;, showing an increase in the concentration of reduced glutathione and a decrease in malondialdehyde.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">516</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Justil-Guerrero Hugo Jesús&lt;sup&gt;1,&lt;/sup&gt;*, Chávez-Flores Juana Elvira&lt;sup&gt;1&lt;/sup&gt;, Cárdenas-Orihuela Robert Armando&lt;sup&gt;1&lt;/sup&gt;, Ramos-Jaco Antonio Guillermo&lt;sup&gt;1&lt;/sup&gt;, Ñañez-del-Pino Daniel&lt;sup&gt;1&lt;/sup&gt;, Vásquez-Quispe Ángel David&lt;sup&gt;1&lt;/sup&gt;, Rojas-Cardenas Nathalie Felicita&lt;sup&gt;1&lt;/sup&gt;, Fernández-Flores Nélber&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Miriam Palomino- Pacheco</style></author><author><style face="normal" font="default" size="100%">Magaly Villena-Tejada</style></author><author><style face="normal" font="default" size="100%">Wilmer Atilio Segura Vílchez</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Capacity of Chuquiraga Spinosa Less. &quot;Huamanpinta&quot; and Prevention of Carrageenan-Induced Inflammation in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoperoxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1287-1296</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the antioxidant capacity of &lt;em&gt;Chuquiraga spinosa &lt;/em&gt;extracts and prevention of carrageenan-induced inflammation in mice. &lt;strong&gt;Methodology:&lt;/strong&gt; Experimental design: plant species, erythrocytes and male BALB C53 mice, were considered as biological material. Antioxidant capacity was evaluated in 50%, 70%, 96% and aqueous ethanolic extracts by 2,2-Diphenyl-1-Picrylhydrazyl reduction, malondialdehyde inhibition in oxidized erythrocytes with H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; and correlating with polyphenol content equivalent to gallic acid/gram dry extract. Inflammation was evaluated by inoculating carrageenan 2% in &quot;subcutaneous air bag&quot; of mice: 1) White, 2) carrageenan, 3) dexamethasone 2 mg/kg, 4-6) ethanolic extract 70% doses 100, 250 and 500 mg/kg respectively; determining nitric oxide, malondialdehyde, total proteins, albumin, leukocytes in exudate and histological changes. &lt;strong&gt;Results: &lt;/strong&gt;Alkaloids, flavonoids, terpenes, phenolic compounds, tannins, carbohydrates, triterpenes, steroids and sesquiterpene lactones were identified; aqueous extract presented greater reduction of 2,2-Diphenyl-1-Picrylhydrazyl (CI50 = 58.99 μg/mL), ethanolic extract 70% presented greater inhibition of malondialdehyde in erythrocytes (CI50 = 16.44 nm/mL); It was observed that the higher the amount of polyphenols, the greater the reduction of 2,2-Diphenyl-1-Picrylhydrazyl (r=-0.909) and the greater the inhibition of malondialdehyde (r=-0.781). With 500 mg/kg of 70% ethanolic extract there was greater anti-inflammatory effect inhibiting malondialdehyde, nitric oxide, albumin, total proteins and leukocytes in 55.55%, 81.92%, 41.20%, 31.51% and 32.45% (p&amp;lt;0.01) respectively and less infiltration of leukocytes and lymphocytes in air sac membrane. &lt;strong&gt;Conclusion: &lt;/strong&gt;The extracts of aerial parts of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; showed antioxidant capacity correlated to polyphenol content. The 70% ethanolic extract prevented inflammation in mice in a dosedependent manner.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1287</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hugo Jesús Justil-Guerrero&lt;sup&gt;1,2&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;1,2&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;1,2,&lt;/sup&gt; Miriam Palomino-Pacheco&lt;sup&gt;1&lt;/sup&gt;, Magaly Villena-Tejada&lt;sup&gt;3,&lt;/sup&gt;*, Wilmer Atilio Segura Vílchez&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacology Laboratory of the Faculty of Medicine of the Universidad Nacional Mayor de San Marcos. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Research Institute of the Faculty of Medicine of the Universidad Nacional Mayor de San Marcos. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Academic Department of Pharmacy, Faculty of Health Sciences, Universidad Nacional de San Antonio Abad del Cusco. Cusco, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Management of Forensic Thanatology of the Institute of Legal Medicine and. Forensic Sciences. Public Prosecutor's Office. Lima, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fernández-Flores N</style></author><author><style face="normal" font="default" size="100%">Rojas-Cardenas NF</style></author><author><style face="normal" font="default" size="100%">Vásquez-Quispe AD</style></author><author><style face="normal" font="default" size="100%">Chávez-Flores Juana E</style></author><author><style face="normal" font="default" size="100%">Justil-Guerrero Hugo J</style></author><author><style face="normal" font="default" size="100%">Parreño-Tipian JM</style></author><author><style face="normal" font="default" size="100%">Silva-Correa Carmen R</style></author><author><style face="normal" font="default" size="100%">Villarreal-La Torre Víctor E</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protection of Erythrocytes against Lipoperoxidation and Antiinflammatory Effects of Ethanolic Extract of Encelia canescens Lam Leaves in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiinflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Carrageenan</style></keyword><keyword><style  face="normal" font="default" size="100%">Encelia canescens Lam</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemolysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoperoxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Malondialdehyde</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">798-804</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Encelia canescens&lt;/em&gt; Lam is a plant traditionally used in Peru for medicinal purposes, and is attributed antioxidant properties, indicating that it could be used in the prevention of non-communicable diseases. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to evaluate the protection of erythrocytes from lipoperoxidation and the anti-inflammatory effect of ethanolic extract of &lt;em&gt;E. canescens&lt;/em&gt; leaves in mice. &lt;strong&gt;Materials and methods: &lt;/strong&gt;Protection from lipoperoxidation was evaluated by inhibition of hemolysis and quantifying malondialdehyde (MDA) concentration against oxidative stress induced with hydrogen peroxide (H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;) at 200, 150, 100, 50 and 25 μg/mL &lt;em&gt;E. canescens&lt;/em&gt; concentrations. The 1% carrageenan-induced air pouch model was used for evaluated inflammation, where albumin, total proteins, MDA, number and leukocyte differentiation were determined in the exudate, and a histopathological evaluation was performed. The concentrations evaluated were 100, 250 and 500 mg/kg of &lt;em&gt;E. canescens&lt;/em&gt;&lt;strong&gt; Results:&lt;/strong&gt; All the concentrations evaluated protected protected erythrocytes from lipoperoxidation (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05), being E.D. value 200 μg/mL. Regarding anti-inflammatory effect, the albumin, total proteins and MDA values of the treatment groups were lower than carrageenan 1% group (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05), but, due to less leukocyte migration and presence of macrophages and the histopathological evaluation, the E.D value was 500 mg/kg. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ethanolic extracts of &lt;em&gt;E. canescens &lt;/em&gt;leaves protect erythrocytes from lipoperoxidation and have dose-dependent anti-inflammatory effects maybe for presence of p-hydroxyacetophenone-derived, and these could be new safer anti-inflammatories.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">798</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fernández-Flores N&lt;sup&gt;1&lt;/sup&gt;, Rojas- Cardenas NF&lt;sup&gt;1&lt;/sup&gt;, Vásquez-Quispe AD&lt;sup&gt;1&lt;/sup&gt;, Chávez-Flores Juana E&lt;sup&gt;1,&lt;/sup&gt;*, Justil-Guerrero Hugo J&lt;sup&gt;1&lt;/sup&gt;, Parreño- Tipian JM&lt;sup&gt;1&lt;/sup&gt;, Silva-Correa Carmen R&lt;sup&gt;2&lt;/sup&gt;, Villarreal-La Torre Víctor E&lt;sup&gt;2,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
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