<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ana L Agüero-Hernández</style></author><author><style face="normal" font="default" size="100%">Catalina Rosales-López</style></author><author><style face="normal" font="default" size="100%">Cristina Herrera</style></author><author><style face="normal" font="default" size="100%">Andrés Vargas-Picado</style></author><author><style face="normal" font="default" size="100%">Rodrigo Muñoz</style></author><author><style face="normal" font="default" size="100%">Ana Abdelnour-Esquivel</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hypoglycemic Effect of Kalanchoe pinnata (Lam) Pers. Leaf Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Kalanchoe pinnata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">557-561</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Kalanchoe pinnata &lt;/em&gt;(Lam) Pers (Crasulaceae) is a succulent ornamental plant. In Costa Rica, the leaves are used as a coadjuvant treatment for &lt;em&gt;Diabetes Mellitus&lt;/em&gt; based on traditional knowledge of natural remedies. Moreover, there are some studies mentioning its use for &lt;em&gt;Diabetes Mellitus&lt;/em&gt; as medicinal plant in several countries. This research aimed to demonstrate the antidiabetic properties of hydroalcoholic extracts of &lt;em&gt;K. pinnata&lt;/em&gt; leaves through phytochemical screening, alpha amylase inhibition and rodent models. &lt;strong&gt;Methods: &lt;/strong&gt;Crude extracts of &lt;em&gt;K. pinnata&lt;/em&gt; leaves were prepared by infusion and decoction using water:ethanol (70:30) as a solvent. The extracts prepared by decoction (LAED, lyophilized-water:ethanoldecoction) and by infusion (LAEI, lyophilized-water:ethanol-infusion) were analyzed by FolinCiocalteu, HPLC and capacity of inhibition of α-amylase activity. To determine hypoglycemic activity in rats, extracts were administered orally at doses of 250, 500 and 750 mg/Kg and blood sugar levels were monitored over a four hours period using a glucometer. &lt;strong&gt;Results:&lt;/strong&gt; A significant reduction (p &amp;lt; 0.05) in blood glucose was observed after one hour in rats treated with 500 mg/Kg of LAED extract. Treatment with 750 mg/Kg LAEI induced a statistically significant reduction in blood sugar at 90, 180 and 240 min, showing that the glucose-lowering effect of this extract was greater at a higher concentration. &lt;strong&gt;Conclusions: &lt;/strong&gt;This study confirmed the hypoglycemic effect of &lt;em&gt;K. pinnata&lt;/em&gt; extracts in the acute phase in rats and supports the use of this Crassulaceae as a home remedy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">557</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ana L. Agüero-Hernández&lt;sup&gt;1,&lt;/sup&gt;*, Catalina Rosales-López&lt;sup&gt;1&lt;/sup&gt;, Cristina Herrera&lt;sup&gt;2&lt;/sup&gt;, Andrés Vargas-Picado&lt;sup&gt;3&lt;/sup&gt;, Rodrigo Muñoz&lt;sup&gt;3&lt;/sup&gt;&lt;sup&gt;&amp;nbsp;&lt;/sup&gt;and Ana Abdelnour-Esquivel&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigación en Biotecnología (CIB), del Instituto Tecnológico de Costa Rica, Cartago, COSTA RICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto de Investigaciones Farmacéuticas (INIFAR), Facultad de Farmacia, Universidad de Costa Rica, San José, COSTA RICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro Nacional de Innovaciones Biotecnológicas (CENIBiot), San José, COSTA RICA.&lt;/p&gt;
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