<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ratna Djamil</style></author><author><style face="normal" font="default" size="100%">Deni Rahmat</style></author><author><style face="normal" font="default" size="100%">Sarah Zaidan</style></author><author><style face="normal" font="default" size="100%">Maya Nur latifah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anticholesterol Activity of Okra Fruit Extract (Abelmoschus esculentus (L) Moench) and Its Nanoemulsion in vivo</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Abelmoschus esculentus L. Moench</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypercholesterolemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticles</style></keyword><keyword><style  face="normal" font="default" size="100%">Okra fruits</style></keyword><keyword><style  face="normal" font="default" size="100%">Total cholesterol level</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">316-320</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Okra fruit has phytosterol, pectin that has the potential as an anticholesterol. &lt;strong&gt;Objective:&lt;/strong&gt; The purpose of this study was to obtain 70% (v/v) ethanol extract of okra fruit and its nanoparticles and to evaluate their anti-cholesterol activity&lt;em&gt; in vivo&lt;/em&gt;. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Okra fruit was extracted by kinetic maceration and the produced extract was tested for phytochemical screening and anti-cholesterolemi activity &lt;em&gt;in vivo&lt;/em&gt;. The nanoparticles was prepared using a cosolvention method. In this study, DDY white mice was divided into 5 groups, namely normal control, negative control, positive control (simvastatin), the extract (400 mg /kg BW), and the nanoparticles (~ 400 mg /kg BW) group. All groups except normal were fed for 14 days with high cholesterol diet. After 14 days, the induction of hypercholesterolemia was stopped and simvastatin was administrated to positive control and the test groups were treated with the extract and the nanoparticles for 7 days. Measurement of total cholesterol level was carried out by cholesterol stripe test method.&lt;strong&gt; Results:&lt;/strong&gt; The nanoparticles used demonstrated particle size of 134.7 nm and zeta potential of -26.72. The results showed a decrease in total cholesterol levels in positive control, the extract and the nanoparticles group as many as 48.68%; 32.44% and 42.95%, respectively.&lt;strong&gt; Conclusion: &lt;/strong&gt;The nanoparticles can increase the activity of the extract.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">316</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ratna Djamil&lt;sup&gt;1,&lt;/sup&gt;*, Deni Rahmat&lt;sup&gt;2&lt;/sup&gt;, Sarah Zaidan&lt;sup&gt;3&lt;/sup&gt;, Maya Nur latifah&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Phytochemistry, Faculty of Pharmacy, Pancasila University, Jakarta,12640 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory ofTechnology Pharmacy, Faculty of Pharmacy, Pancasila University, Jakarta,12640 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Pharmacy, Pancasila University, Jakarta,12640 INDONESIA.&lt;/p&gt;
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