<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rubiati Hipni</style></author><author><style face="normal" font="default" size="100%">Isnaniah</style></author><author><style face="normal" font="default" size="100%">Noorhayati Maslani</style></author><author><style face="normal" font="default" size="100%">Hapisah</style></author><author><style face="normal" font="default" size="100%">Megawati</style></author><author><style face="normal" font="default" size="100%">Isrowiyatun Daiyah</style></author><author><style face="normal" font="default" size="100%">Ahmad Rizani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening and Antioxidant Activity in Dragon Fruit  Plant Extracts as Immunomodulators in Pregnant Women</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Dragon fruit plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulator</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnant  Women</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">999-1004</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Dragon fruit contains many organic acids, proteins, and minerals such as potassium, magnesium, calcium, iron, and vitamin C. Several natural compounds can increase the activity of the immune system, namely flavonoids, curcumin, limonoids, vitamin C, vitamin E, and catechins. &lt;strong&gt;Objective: &lt;/strong&gt;to analyze the levels of phytochemicals and active ingredients from the fruit, skin, stem, and roots of dragon fruit plants. &lt;strong&gt;Methods: &lt;/strong&gt;This research was carried out experimentally, carried out at the Pucuk Sirih Jamu Factory. This study used fresh and ripe Dragon Fruit Plants directly taken from the Tanah Laut District garden (South Kalimantan), carried out extract preparation, phytochemical screening, and determination of phytochemical levels of red dragon fruit plants. &lt;strong&gt;Results: &lt;/strong&gt;The study found the highest secondary metabolite levels in red dragon fruit for Flavonoids in the stem (0.74%), Alkaloids in the stem (4.21%), Saponins in fruit flesh (0.45%), and Steroids in roots (2.54%). Antioxidant activity in red dragon fruit flesh (78.23%), stem (79.13%), root (8.64%), and skin (11.24%). The highest antioxidant activity in red dragon fruit stems.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; There are groups of secondary metabolites and antioxidants contained in dragon fruit plants (fruit, skin, stems, and roots) from Kalimantan Selatan (Indonesia).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">999</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rubiati Hipni*, Isnaniah, Noorhayati Maslani, Hapisah, Megawati, Isrowiyatun Daiyah, Ahmad Rizani&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Midwifery Department of Politeknik Kemenkes Banjarmasin, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dewita</style></author><author><style face="normal" font="default" size="100%">Desmelati</style></author><author><style face="normal" font="default" size="100%">Santhy W. Sidauruk</style></author><author><style face="normal" font="default" size="100%">Taufik Hidayat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Isolation and Characterization of Snakehead Fish Meal Extract with Fresh, Boiled, and Steamed Treatments and Its Potential for Health Drinks and  Immunomodulators</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Food product</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulator</style></keyword><keyword><style  face="normal" font="default" size="100%">Sds page.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">532-536</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Albumin is one of the proteins that currently have an important role for the organism's body. This study aims to determine the characteristics of albumin with several treatments which will later be applied to cendol drinks. The treatments for extraction and albumin flour were fresh, boiled, and steamed, which were tested for extract yield, amino acids, and molecular identification using SDS-Page. The results showed that the steam treatment of the extract produced the highest yield of 0.42g/dL. The highest amino acid was in albumin flour with boiled treatment, namely each essential amino acid, namely leucine and non-essential amino acid, namely leucine. Identification of albumin molecular weight showed that albumin was found only in fresh and flour conditions when fresh. Other results indicate the possibility of processing factors affecting the presence of albumin which is easily soluble in water. albumin isolation from snakehead fish can potentially be developed into immunomodulatory health products&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">532</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dewita&lt;sup&gt;1,*&lt;/sup&gt;, Desmelati&lt;sup&gt;1&lt;/sup&gt;, Santhy W. Sidauruk&lt;sup&gt;1&lt;/sup&gt;, Taufik Hidayat&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Fishery Products Technology, University of Riau, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Center for Agroindustry, National Innovation Research Agency, Laptiab Building 614 Puspiptek Serpong, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tias Pramesti Griana</style></author><author><style face="normal" font="default" size="100%">Tri Yudani Mardining Raras</style></author><author><style face="normal" font="default" size="100%">Karyono Mintaroem</style></author><author><style face="normal" font="default" size="100%">Iin Noor Chozin</style></author><author><style face="normal" font="default" size="100%">Catur Saptaning Wilujeng</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunosuppressive Activity of Goat Kefir in a Rat Model with Bleomycin-induced Pulmonary Fibrosis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bleomycin</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokine</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulator</style></keyword><keyword><style  face="normal" font="default" size="100%">Kefir</style></keyword><keyword><style  face="normal" font="default" size="100%">Pulmonary fibrosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1594-1599</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to investigate the immunomodulatory capacity of goat kefir on pulmonary fibrosis rat model. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Twenty-five male rats were randomly divided into five groups: one group only received induction with bleomycin (0.3 mg/rat) to induce pulmonary fibrosis; three groups were treated with different doses (2.5, 3.5, and 4.5 mL/200 g BW) of goat kefir, following the induction with bleomycin, for 30 days; and one group served as negative control, did not receive bleomycin induction as well as kefir. On day 30, all the animals were sacrificed. Plasma levels of TGF-β, IL-4, and IFN-y were measured using the ELISA method, and the expression of α-SMA in myofibroblast cells was examined with the help of immunohistochemistry assay. &lt;strong&gt;Results:&lt;/strong&gt; Induction with bleomycin significantly elevated the expressions of TGF-β, IL-4, and IFN-y in comparison to the control group. Following the administration of kefir (3.5 and 4.5 mL/200 g BW), the concentration of TGF-β was significantly decreased (p&amp;lt;0.05); whereas, the concentration of IFN-y increased slightly (p&amp;lt;0.05) only in the group that received the 4.5 mL/200 g BW dose of kefir. In contrast, IL-4 exhibited increasing levels with higher doses of kefir (p&amp;lt;0.05). The expression of α-SMA in myofibroblasts showed a tendency to decline following the administration of kefir, although this decline was not statistically significant.&lt;strong&gt; Conclusions:&lt;/strong&gt; Goat kefir caused a reduction in the TGF-β levels in fibrosis conditions; however, the kefir elicited an immunosuppressive effect during the progression of the pulmonary fibrosis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1594</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tias Pramesti Griana&lt;sup&gt;1,2,&lt;/sup&gt;*, Tri Yudani Mardining Raras&lt;sup&gt;3&lt;/sup&gt;, Karyono Mintaroem&lt;sup&gt;4&lt;/sup&gt;, Iin Noor Chozin&lt;sup&gt;5&lt;/sup&gt;, Catur Saptaning Wilujeng&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomy, Faculty of Medicine and Health Science, State Islamic University Maulana Malik Ibrahim Malang, Jl. Gajayana No.50, Malang 65144, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Master Program on Biomedical Science, Faculty of Medicine, Brawijaya University, Jl. Veteran, Malang, Jawa Timur 65145, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Brawijaya University, Jl. Veteran, Malang, Jawa Timur 65145, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Brawijaya University, Jl. Veteran, Malang, Jawa Timur 65145, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pulmonology, Saiful Anwar Hospital, Jl. Jaksa Agung Suprapto No.2, Malang 65112, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Nutrition, Faculty of Medicine, Brawijaya University, Jl. Veteran, Malang, Jawa Timur 65145, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Gita Rahma Yanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunomodulator Activity of Ethanol Extract of Tapak Liman Leaves (Elephantopus scaber Linn.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carbon clearance</style></keyword><keyword><style  face="normal" font="default" size="100%">Elephantopus scaber Linn.</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulator</style></keyword><keyword><style  face="normal" font="default" size="100%">Leucocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Lymph</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1419-1427</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Tapak Liman (&lt;em&gt;Elephantopus scaber&lt;/em&gt; Linn) is a medicinal plant in Indonesia which traditionally used as a treatment for fever, gout, dysentery, hepatitis, and infections.&lt;strong&gt; Aim:&lt;/strong&gt; This study aims to determine the immunostimulants activity of tapak liman extract with carbon clearance method and to determine the percentage and total leukocytes and relative lymph weights.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Twenty white male mice divide assigned to 1 control group and 3 experimental groups. It treated by oral administration of tapak liman extract; 10, 30, and 100 mg/kgBW. After six days of administration, mice intravenously injected with 0.1 ml/10gBW colloidal carbon. Blood obtained from the mice tail at; 3rd, 6th, 9th, 12th and 15th minutes. The determined absorbance then calculated to obtain the phagocytotic index, the percentage and the total of leukocyte cells and lymph weights. &lt;strong&gt;Results: &lt;/strong&gt;Phagocytosis index increased significantly at 1, 12, 1.24 and 1.47. The percentages of neutrophil segment are 57%, 60% and 60%, for lymphocytes are 3, 80%, 32.80% and 34.20%, monocyte cells are 4.60%, 3.00% and 2.60%, neutrophil are 3.40%, 3.20%,2.20%, and for the eosinophil cells are 3.20%, 1.8% and 1.20%. Total leukocyte cells are 10,760, 11,630 and 15,880 cells/microliter. The relative lymph weight of each dose in the sequence is 0.36, 0.49 and 0.66. &lt;strong&gt;Conclusion: &lt;/strong&gt;Ethanol extract of tapak liman leaves (&lt;em&gt;Elephantopus scaber&lt;/em&gt; Linn) can increase the immunity of mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1419</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yufri Aldi*, Dwisari Dillasamola, Gita Rahma Yanti &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Department of Pharmacology, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;
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