<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kishor Mazumder</style></author><author><style face="normal" font="default" size="100%">Ziku Chandra Dey</style></author><author><style face="normal" font="default" size="100%">Suparna Dey</style></author><author><style face="normal" font="default" size="100%">Md. Fazlul Kabir</style></author><author><style face="normal" font="default" size="100%">Minhazur Rahman</style></author><author><style face="normal" font="default" size="100%">Sadiur Rahman Sajon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti-diarrheal and Anti-nociceptive Activity of Methanolic Unripe Fruit Peels Extract of Masua ferrea Linn. on Mice Models</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diarrheal</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-nociceptive</style></keyword><keyword><style  face="normal" font="default" size="100%">Castor oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Intestinal transit</style></keyword><keyword><style  face="normal" font="default" size="100%">Mesua ferrea</style></keyword><keyword><style  face="normal" font="default" size="100%">Tail immersion method</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">828-835</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Though traditionally the plant &lt;em&gt;Masua ferrea &lt;/em&gt;has been used by south east Asian people in inflammation and septic conditions, the present study was designed to investigate the anti-diarrheal and anti-nociceptive activities of unripe fruit peel of &lt;em&gt;Mesua ferrea&lt;/em&gt; on animal models. &lt;strong&gt;Methods:&lt;/strong&gt; Various methods were employed for investigating these activities such as castor-oil induced diarrhea, castor-oil induced enteropooling and gastrointestinal motility test, acetic acid induced writhing test, tail immersion and hot plate methods. &lt;strong&gt;Results: &lt;/strong&gt;From the experimental data it was found that the diarrheal episode was inhibited by 39.68% and 49.21% for methanol extract at the doses of 100 and 200 mg/kg respectively. The extract significantly lessened the intestinal volume for methanolic extract at 200 mg/Kg dose 0.54 ± 0.01 ml (&lt;em&gt;p &lt;/em&gt;&amp;lt; 0.05) and at 200 mg/Kg dose 0.47 ± 0.02 ml (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.01) compared to control 0.65 ± 0.03 ml in castor-oil induced enteropooling and also decreased intestinal transit 29.07 – 48.54% for methanolic extract comparable with standard (loperamide 5 mg/kg). &lt;em&gt;Mesua ferrea&lt;/em&gt; peels significantly (&lt;em&gt;P&lt;/em&gt; &amp;lt; 0.05, &lt;em&gt;P&lt;/em&gt; &amp;lt; 0.01 and &lt;em&gt;P&lt;/em&gt; &amp;lt; 0.001) reduced the number of writhing, increased latency to flick tail in tail immersion method and elevated the mean basal reaction time in hot plate method respectively. Besides, no delayed toxicity was observed in given doses. &lt;strong&gt;Conclusion:&lt;/strong&gt; The methanolic extract exhibited highly significant anti-diarrheal and antinociceptive activity in a dose-dependent manner, which supports its use in traditional herbal medicine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">828</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kishor Mazumder&lt;sup&gt;1,3,*&lt;/sup&gt;, Ziku Chandra Dey&lt;sup&gt;2&lt;/sup&gt;, Suparna Dey&lt;sup&gt;4&lt;/sup&gt;, Md. Fazlul Kabir&lt;sup&gt;2&lt;/sup&gt;, Minhazur Rahman&lt;sup&gt;2&lt;/sup&gt;, Saidur Rahaman sajon&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Jessore University of Science and Technology, Jessore-7408, Jessore, BANGLADESH.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;University of Science and Technology Chittagong (USTC), Chittagong, BANGLADESH.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Biomedical Sciences and Graham Centre for Agricultural Innovation, Charles Sturt University, Boorooma St, Wagga Wagga, NSW, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Center for Specialized Care and Research, Chittagong-4000, BANGLADESH.&lt;/p&gt;
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