<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paola Raunelli</style></author><author><style face="normal" font="default" size="100%">Danae Liviac</style></author><author><style face="normal" font="default" size="100%">Rafael Alvis</style></author><author><style face="normal" font="default" size="100%">Silvio Puente</style></author><author><style face="normal" font="default" size="100%">Ivan Best</style></author><author><style face="normal" font="default" size="100%">Oscar Reategui</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytoprotective Effect of the Eryngium foetidum &quot;Sacha Culantro&quot; Methanolic Leaf Extract Versus Sodium Fluoride Exposed Mice using the Micronucleus Test and the Comet Assay</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Comet assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Eryngium foetidum</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Micronucleus test</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">461-465</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Eryngium foetidum&lt;/em&gt;, commonly known as sacha culantro, is a plant that grows in the Peruvian Amazonian jungle, studied for its high concentration of antioxidant substances and various ethnopharmacological properties. The main goal of the study is to observe the cytoprotective and antioxidant effect of the extract from its leafs in &lt;em&gt;Mus musculus&lt;/em&gt; previously administered with Sodium fluoride (NaF) using the Micronucleus test and the Comet assay. &lt;strong&gt;Methods: &lt;/strong&gt;The extract was administrated orally in four different concentrations: 180, 360, 720, 1440 mg/Kg for ten days, at the 11&lt;sup&gt;th&lt;/sup&gt; day a single dose of NaF was administrated via intraperitoneal at 20 mg/Kg. The genotoxicity study was made with mice from the strain BALB/c, using the Micronucleus test on bone marrow and the Comet assay on peripheral blood according the OECD guides 474 and 489 respectively. The statistical analysis was made by the media’s analysis with ANOVA. &lt;strong&gt;Results: &lt;/strong&gt;Significant differences were found in Micronucleus frequency between the highest concentrations of &lt;em&gt;Eryngium foetidum&lt;/em&gt; and NaF. The Comet assay showed significant reduction in NaF induced damage according to different concentrations of the extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; The &lt;em&gt;Eryngium foetidum&lt;/em&gt; extract has cytoprotective activity against oxidant substances such as NaF.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">461</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paola Raunelli&lt;sup&gt;1,2&lt;/sup&gt;, Danae Liviac&lt;sup&gt;3&lt;/sup&gt;, Rafael Alvis&lt;sup&gt;3&lt;/sup&gt;, Silvio Puente&lt;sup&gt;4&lt;/sup&gt;, Ivan Best&lt;sup&gt;1,5,6&lt;/sup&gt; Oscar Reátegui&lt;sup&gt;1,7,*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Universidad Científica del Sur, Panamericana Sur Km 19, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Medical School, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Cellular and Molecular Biology, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Nutrition and Dietetic School, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Hersil S. A. Laboratorios Industriales Farmacéuticos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Grupo de Ciencia, Tecnología e Innovación en Alimentos, Universidad San Ignacio de Loyola, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Agroforestry Engineering School, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;
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