<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dennis R.A. Mans</style></author><author><style face="normal" font="default" size="100%">Terrence Mawie</style></author><author><style face="normal" font="default" size="100%">Priscilla Friperson</style></author><author><style face="normal" font="default" size="100%">Meryll Djotaroeno</style></author><author><style face="normal" font="default" size="100%">Jennifer Pawirodihardjo</style></author><author><style face="normal" font="default" size="100%">Vinoj H. Sewberath Misser</style></author><author><style face="normal" font="default" size="100%">Ed P.F. Ijzerman</style></author><author><style face="normal" font="default" size="100%">Walther Jap Tjoen San</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Platelet Aggregation-Stimulatory, Antibacterial, and Cytotoxic Activities of the Fresh Stem Juice from Montrichardia arborescens Schott (Araceae) – Evidence for Wound Healing- Stimulatory Properties</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Broth microdilution</style></keyword><keyword><style  face="normal" font="default" size="100%">In vitro studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Lack of cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Montrichardia arborescens Schott</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Platelet aggregation stimulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Preliminary Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">PRP</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem juice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">299-306</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Montrichardia arborescens&lt;/em&gt; is traditionally used for wound healing, but without scientific evidence. In this study, the fresh stem juice was assessed for its platelet aggregation stimulatory and antibacterial activities and its safety. &lt;strong&gt;Methods: &lt;/strong&gt;The stem juice was evaluated at various dilutions for platelet aggregation-stimulatory activity in human platelet rich plasma (PRP) using norepinephrine as a positive control; antibacterial activity against &lt;em&gt;Staphylococcus aureus&lt;/em&gt; and &lt;em&gt;Streptococcus pyogenes&lt;/em&gt; (gram-positive bacteria) as well as &lt;em&gt;Escherichia coli&lt;/em&gt; and Pseudomonas aeruginosa (gram-negative bacteria) in a broth microdilution method using tetracycline as a reference compound; and absence of substantial cytotoxicity against cultured CHO cells in an MTT assay. Data (means ± SDs; n ≥ 3) were evaluated for statistically significant differences (p &amp;lt; 0.05) using ANOVA with Bonferroni’s adjustments. &lt;strong&gt;Results: &lt;/strong&gt;The stem juice stimulated platelet aggregation to nearly 100% at 50% (&lt;em&gt;v/v&lt;/em&gt;) dilution and about 50% at 12.5% (&lt;em&gt;v/v&lt;/em&gt;) dilution. It did not affect the growth of &lt;em&gt;E. coli &lt;/em&gt;and &lt;em&gt;P. aeruginosa&lt;/em&gt; at 50% (&lt;em&gt;v/v&lt;/em&gt;) but partially inhibited that of &lt;em&gt;S. aureus&lt;/em&gt; at 37.5% (&lt;em&gt;v/v&lt;/em&gt;) and that of &lt;em&gt;S. pyogenes&lt;/em&gt; completely at 12.5% (&lt;em&gt;v/v&lt;/em&gt;). These effects were validated by those found with epinephrine 20 μM and tetracycline 10-60 μg/mL. CHO cell survival was only 3 ± 1% with the 50% (&lt;em&gt;v/v&lt;/em&gt;) diluted stem juice but 64 ± 2% with the 12.5% (v/v) dilution. &lt;strong&gt;Conclusion: &lt;/strong&gt;The &lt;em&gt;M. arborescens&lt;/em&gt; stem juice exhibited substantial platelet aggregation-stimulatory and antibacterial activity at 12.5% (&lt;em&gt;v/v&lt;/em&gt;) dilution which seemed safe to the normal tissues. These findings confirm its traditional use for wound healing.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">299</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dennis R.A. Mans&lt;sup&gt;1*&lt;/sup&gt;, Terrence Mawie&lt;sup&gt;2&lt;/sup&gt;, Priscilla Friperson&lt;sup&gt;1&lt;/sup&gt;, Meryll Djotaroeno&lt;sup&gt;1&lt;/sup&gt;, Jennifer Pawirodihardjo&lt;sup&gt;1&lt;/sup&gt;, Vinoj H. Sewberath Misser&lt;sup&gt;1&lt;/sup&gt;, Ed P.F. Ijzerman&lt;sup&gt;2&lt;/sup&gt;, Walther Jap Tjoen San&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, SURINAME.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Microbiology, Academic Hospital Paramaribo, Paramaribo, SURINAME.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Cardiology, Academic Hospital Paramaribo, Paramaribo, SURINAME.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">S Lalitha</style></author><author><style face="normal" font="default" size="100%">D Anusha</style></author><author><style face="normal" font="default" size="100%">Yogeshkumar Murkunde</style></author><author><style face="normal" font="default" size="100%">Viji Devanand</style></author><author><style face="normal" font="default" size="100%">K Maheshkumar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Cancer Activity of Cayratia Auriculata Ethanolic Extracts Against Cancer Cell Line A549  An In Vitro Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Activity against cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell line cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">495-499</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The purpose of this study was to evaluate the anticancer activity of ethanolic &lt;em&gt;cayratia auriculata&lt;/em&gt; extracts using the A549 cell line MTT assay. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Using Soxhlet apparatus, ethanolic extracts from &lt;em&gt;cayratia auriculata &lt;/em&gt;were prepared. The cancer cells were exposed to 12.5, 25, 50 , 100 , 150, 200 μg / mL and incubated for 24 h at different concentrations. Compared with control, &lt;em&gt;C. auriculata&lt;/em&gt; exhibited a cytotoxic effect. &lt;strong&gt;Results: &lt;/strong&gt;At 150 and 200μg / ml concentrations, with 61 percent and 73.7 percent respectively, the highest cytotoxicity was identified. The findings show that cytotoxicity is directly proportionate to the concentration of the extract. IC50 of the ethanolic extract value of &lt;em&gt;C. auriculata&lt;/em&gt; was found to be 102.9μg / ml against the A549 cell line. &lt;strong&gt;Conclusion:&lt;/strong&gt; In the present analysis, &lt;em&gt;C.auriculata &lt;/em&gt;ethanolic extract was shown to be a strong suppressant for cell division and proliferation. As for anti-tumor medicine, it can be a new source and can be effectively used as an immunological anti-malignant compound.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">495</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;S. Lalitha&lt;sup&gt;1&lt;/sup&gt;, D. Anusha&lt;sup&gt;2,&lt;/sup&gt;*, Yogeshkumar Murkunde&lt;sup&gt;3&lt;/sup&gt;, Viji Devanand&lt;sup&gt;4&lt;/sup&gt;, K.Maheshkumar&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Demonstrator, Department of Physiology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research centre (SRIHER), Porur, Chennai -600116, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor, Department of Pharmacology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research centre (SRIHER), Porur, Chennai -600116, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Test Head Animal House/Facility Management (CEFT), Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research centre (SRIHER), Porur, Chennai -600116, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;HOD &amp;amp; Professor, Department of Physiology, Stanley Medical College&amp;amp; Hospital, Royapuram, Chennai -600001, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Assistant Medical officer/Lecture Grade II, Department of Biochemistry and Physiology, Government Yoga and Naturopathy Medical college and Hospital, Chennai -600106, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Hanifa Nurul Fitri</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity Study of Ethanol Extract of Bintangor Leaf (Calophyllum soulattri Burm.f) on T47D Breast Cancer Cell Line (Cytotoxicity Study with MTT Assay Method)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bintangor Leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast Cancer Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Calophyllum soulattri Burm.f</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">362-367</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The public has used Bintangor leaf (&lt;em&gt;Calophyllum soulattr&lt;/em&gt;i Burm.f) for various medical treatments, including treated inflamed eyes and gout. Aim: This research aimed to determine the cytotoxic effect of ethanol extract and fraction of &lt;em&gt;Calophyllum soulattri &lt;/em&gt;Burm. f leaf toward T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cell. &lt;strong&gt;Methods:&lt;/strong&gt; The test used T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cells, the 3-4,5-dimethylthiazol-2yl -2,5-diphenyltetrazolium bromide (MTT) test method, and ELISA Reader to determine the absorbance. This method's principle was the presence of tetrazolium salts by the reductase system in the mitochondria of living cells formed purple formazan crystals. The used parameter was the value of IC&lt;sub&gt;50&lt;/sub&gt;.&lt;strong&gt; Results:&lt;/strong&gt; The result showed that ethanol extract, n-hexane fraction, ethyl acetate fraction, and butanol fraction did not have a cytotoxic effect on T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cell. The values of IC&lt;sub&gt;50&lt;/sub&gt; respectively are 585.31 μg/ml; 409.33 μg/ ml; 534.08 μg/ml; and 563.22 μg/ml. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ethanol extract and &lt;em&gt;Calophyllum soulattri&lt;/em&gt; Burm.f leaf fraction did not have a cytotoxic effect on T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cells.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">362</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Fatma Sri Wahyuni, Hanifa Nurul Fitri, Elsa Badriyya&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ribhu Ray</style></author><author><style face="normal" font="default" size="100%">Amrita Pal</style></author><author><style face="normal" font="default" size="100%">Santanu Paul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of the Impact of Wild Stinkhorn Mushroom Extracts on Different Cancer Cell Proliferation and Study of Primary Metabolites</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ABTS•+</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Phallus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">699-708</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Present study aims to evaluate the efficacy of methanolic and ethyl acetate extracts of wild mushroom &lt;em&gt;Phallus&lt;/em&gt; sp. on cell proliferation of both normal and cancer cells. This study also looked at anti-oxidant potentiality of methanolic extract and also unravels the phytochemical profiling of both extracts. &lt;strong&gt;Methods: &lt;/strong&gt;Anti-proliferative activity was assessed by MTT assay on different human cancer cell lines such as MCF-7, MOLT-4, REH and Peripheral Blood Mononuclear Cells or PBMC isolated from a healthy donor. Gas Chromatography-Mass Spectrometry (GC-MS) analysis was used for comparative assessment of phytochemical constituents of both extracts. The anti-oxidant profile of methanolic extract was also evaluated by DPPH and ABTS&lt;strong&gt;•+&lt;/strong&gt; assays. &lt;strong&gt;Results:&lt;/strong&gt; Results indicated that the both methanolic and ethyl acetate extracts of &lt;em&gt;Phallus&lt;/em&gt; sp. showed appreciable anti-proliferative activity against breast cancer cell line MCF-7 with IC&lt;sub&gt;50&lt;/sub&gt; of 8.544±2.812 μg/mL and 35.279±2.863 μg/mL respectively. Both of the extracts also showed its moderate impact on human B cell precursor leukemia cell line (REH) with IC&lt;sub&gt;50&lt;/sub&gt; of 25.987±2.696 μg/mL for methanol and 51.484±1.480 μg/mL for ethyl acetate extract respectively. No effect was observed in MOLT-4 cell line. Methanolic extract was selected as better anti cancer extract over ethyl acetate extract. No significant anti-proliferative activity was observed in normal PBMC by both extracts. GC-MS analysis indicated that 43 and 114 compounds were identified from methanolic and ethyl acetate extracts respectively. Among them nine compounds shared its existence in both of the extracts. Different derivatives of ergosterol and several fatty acid esters ware identified as major components from both of the extracts. Methanolic extracts of the &lt;em&gt;Phallus&lt;/em&gt; sp. showed its effectiveness on both of DPPH and ABTS&lt;strong&gt;•+ &lt;/strong&gt;free radical, and result indicated that it contain more flavonoid content than phenol. &lt;strong&gt;Conclusion:&lt;/strong&gt; The methanolic extract of &lt;em&gt;Phallus&lt;/em&gt; sp. show very specific anti-proliferative effect on MCF-7 with moderate anti-oxidant activity and holds a great promise for isolation of bio molecules for treating Breast Cancer. Several derivatives of ergosterol identified as probable anti-cancer compound.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">699</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ribhu Ray, Amrita Pal, Santanu Paul* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Laboratory of Cell and Molecular Biology, Department of Botany, University of Calcutta, Kolkata 700019, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amrita Pal</style></author><author><style face="normal" font="default" size="100%">Anirban Chouni</style></author><author><style face="normal" font="default" size="100%">Arpan Das</style></author><author><style face="normal" font="default" size="100%">Ribhu Ray</style></author><author><style face="normal" font="default" size="100%">Santanu Paul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti-proliferative Potential and Antioxidant Activity of a Wild Edible Mushroom Macrocybe crassa (Sacc.) Pegler and Lodge</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Macrocybe crassa</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF7</style></keyword><keyword><style  face="normal" font="default" size="100%">MOLT-4</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1504-1510</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study aims to quantify the anti-oxidant activity of the methanolic extract of &lt;em&gt;Macrocybe crassa &lt;/em&gt;and its anti-proliferative activity on normal and cancer cells. &lt;strong&gt;Methods:&lt;/strong&gt; The anti-oxidant potential of the extract was determined by several&lt;em&gt; in vitro&lt;/em&gt; assay system like DPPH radical scavenging activity, superoxide anion scavenging activity, percentage inhibition of lipid peroxidation and nitric oxide (NO) scavenging activity. Anti-proliferative activity was tested by MTT assay on breast cancer cell line MCF7, Human acute T lymphoblastic leukaemic cell MOLT-4 and Peripheral Blood Mononuclear Cells or PBMC isolated from a healthy donor to check its cytotoxic effect on normal cells. &lt;strong&gt;Results: &lt;/strong&gt;Results indicated that the methanolic extract of &lt;em&gt;Macrocybe crassa&lt;/em&gt; shows appreciable anti-proliferative activity against breast cancer cell line MCF7 and negligible effect on MOLT4 cells. In contrast no significant anti-proliferative effect has been observed in normal PMMCs. Moderate anti-oxidant activity was recorded in methanolic extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; Methanolic extract of of &lt;em&gt;Macrocybe crassa&lt;/em&gt; with moderate anti-oxidant activity and specific anti-proliferative effect on MCF7 holds a great promise can be used for isolation of bio molecules for treating Breast Cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1504</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amrita Pal, Anirban Chouni, Arpan Das, Ribhu Ray, Santanu Paul* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Laboratory of Cell and Molecular Biology, Department of Botany, University of Calcutta, Kolkata 700019, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sangeetha DN</style></author><author><style face="normal" font="default" size="100%">S. Rajamani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Antidiabetic Activity of Methanolic Leaf Extract of Indianthus virgatus (Roxb.) Suksathan and Borchs by Glucose Uptake Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">In vitro cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Indianthus virgatus (Roxb.) Suksathan and Borchs</style></keyword><keyword><style  face="normal" font="default" size="100%">L-6 cell line</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanolic leaf extract</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Skeletal muscle Cell Lines</style></keyword><keyword><style  face="normal" font="default" size="100%">Therapeutic agents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">674-677</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Medicinal plants play a key role to cure many diseases from time immemorial. The usage of medicinal plants in traditional medicinal system is the vital process of India. Diabetes Mellitus is a systemic metabolic disease characterized by hyperglycemia, abnormal elevated levels of lipid and fat in blood and hypoinsulinaemia. The current epidemic of diabetes indicates the need of proper and effective medications that are limited in their potency to have many side effects. Thus, introduction of alternative and complementary medicine is now in picture. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective of this work is to evaluate the &lt;em&gt;in vitro&lt;/em&gt; anti diabetic activity of methanolic extracts of &lt;em&gt;Indianthus virgatus&lt;/em&gt; (Roxb.) Suksathan and Borchs in skeletal muscle cell line. &lt;strong&gt;Methods:&lt;/strong&gt; The &lt;em&gt;in vitro &lt;/em&gt;cytotoxicity was performed for leaf extract (Methanol) on L-6 (Rat skeletal muscle) cell line to find toxic concentration of the leaf extract by MTT assay. Glucose uptake activity of test substance was determined in differentiated L-6 cells. &lt;strong&gt;Results:&lt;/strong&gt; In Glucose uptake assay, Methanol Extract exhibited moderate toxicity to skeletal muscle cell line and glucose uptake assay it shows dose dependent glucose uptake. Glucose uptake rate increased with the increasing concentration of the leaf extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of the current study clearly demonstrated the antidiabetic potency of methanolic leaf extract obtained from &lt;em&gt;Indianthus virgatus &lt;/em&gt;(Roxb.) Suksathan and Borchs. under &lt;em&gt;in vitro &lt;/em&gt;model.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">674</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sangeetha DN&lt;sup&gt;1,&lt;/sup&gt;*, S. Rajamani&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Bharathiar University, Coimbatore, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department of Botany, St. Josephs’ Post Graduate and Research Centre, Bengaluru, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dina M Eskander</style></author><author><style face="normal" font="default" size="100%">Ezzel -Din A El-Khrisy</style></author><author><style face="normal" font="default" size="100%">Mary H Grace</style></author><author><style face="normal" font="default" size="100%">Marian Nabil</style></author><author><style face="normal" font="default" size="100%">Mahmoud I Nassar</style></author><author><style face="normal" font="default" size="100%">Marwa M Mounier</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Investigation of Secondary Metabolites and Cytotoxicity of Jacquemontia pentantha (Jacq.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Enzyme-Linked Immunosorbent Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Jacquemontia pentantha</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterols</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpenes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">718-723</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The aim of this study is to isolate and identify sterols and terpenes from the chloroform/methanol extract (3:1) of aerial parts of &lt;em&gt;Jacquemontia pentantha&lt;/em&gt; (Jacq.) and evaluation of cytotoxic activity of crude extract and phytol for the first time from this plant. &lt;strong&gt;Methods:&lt;/strong&gt; Different chromatographic techniques for the aerial parts of &lt;em&gt;Jacquemontia pentantha&lt;/em&gt; extract were used resulting in isolation of eight compounds. Their structures were elucidated by spectroscopic methods including&lt;sup&gt; 1&lt;/sup&gt;HNMR, &lt;sup&gt;13&lt;/sup&gt;CNMR, EI/MS spectrometry and by comparing their data with those reported in the literature. The cytotoxicity was evaluated using MTT assay. The mode of action of the extract was predicted by using Enzyme-linked Immunosorbent Assay Kit for Tubulin beta (TUBb). &lt;strong&gt;Results: &lt;/strong&gt;Eight compounds for the first time from this plant were identified as Palmitic acid (1), Phytol (major) (2), Stigmast-4-en- 3-one (3), mixture of α-amyrin (4) and β–amyrin (5), 1,6,10,14,18,22-Tetracosahexaen-3- ol,2,6,10,15,19,23-hexamethyl (all-E) (6) and mixture of α– amyrin acetate (7) and β-amyrin acetate (8). The extract showed potent cytotoxic activity on MCF-7 breast carcinoma cell line as well as HCT-116 colon carcinoma cell line at different concentrations (100-6.25 ug/ml) with IC&lt;sub&gt;50&lt;/sub&gt; (21.8 ± 0.9) and (40.9 ± 1.3) respectively. Phytol showed potent cytotoxic activity on MCF-7 cell line at different concentrations (100-12.5 ug/ml) with IC&lt;sub&gt;50&lt;/sub&gt; (60 ± 2.4), while it had no cytotoxic effect on HCT-116 cell line. The extract showed significant TUBb polymerization inhibition activity. &lt;strong&gt;Conclusion: &lt;/strong&gt;The extract of aerial parts of &lt;em&gt;Jacquemontia pentantha &lt;/em&gt;(Jacq.) and also phytol compound has cytotoxic activity due to the presence of phytochemicals such as sterols and terpenes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">718</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dina M Eskander&lt;sup&gt;1,*&lt;/sup&gt;, Ezzel -Din A El-Khrisy&lt;sup&gt;1&lt;/sup&gt;, Mary H Grace&lt;sup&gt;2&lt;/sup&gt;, Marian Nabil&lt;sup&gt;1&lt;/sup&gt;, Mahmoud I Nassar&lt;sup&gt;1&lt;/sup&gt;, Marwa M Mounier&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Chemistry of Natural Compounds Department, National Research Centre, Dokki, 12622 Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Plants for Human Health Institute, Food Bioprocessing and Nutrition Sciences Department, North Carolina State University, North Carolina Research Campus, NC, USA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, Drug Bioassay-Cell Culture Laboratory, National Research Centre, Dokki, 12622 Cairo, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rinto Muhammad Nur</style></author><author><style face="normal" font="default" size="100%">Laurentius Hartanto Nugroho</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Activities of Fractions from Dioscorea bulbifera L. Chloroform and Methanol Extracts on T47D Breast Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">D. bulbifera</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Secondary metabolites</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/362</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">33-38</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To elucidate cytotoxic activity of fractions from chloroform and methanol extracts of &lt;em&gt;D. bulbifera &lt;/em&gt;organs on T47D breast cancer cells. &lt;strong&gt;Method:&lt;/strong&gt; The vegetative organs of &lt;em&gt;D. bulbifera&lt;/em&gt; were extracted gradually using chloroform and methanol. Cytotoxicity tested on T47D cells using MTT Assay. The most toxic extract was fractioned by vacuum liquid chromatography (VLC) followed by thin layer chromatography (TLC). The extract and fractions potential were tested on the Vero cells using the same method as cancer cells. The most toxic fraction was analyzed using TLC followed by the application of various spray reagents for the identification of active compound. &lt;strong&gt;Results:&lt;/strong&gt; The chloroform extract of the &lt;em&gt;D. bulbifera &lt;/em&gt;leaves was the highest cytotoxic on T47D cells (IC&lt;sub&gt;50&lt;/sub&gt; 115.63&amp;plusmn;86.01 &amp;mu;g/mL). Moreover, the cytotoxicity test on the combined fractions of leaves chloroform extract showed that fraction 5 (F5) and fraction 6 (F6) were the most toxic fractions compared to those of other fractions. The IC&lt;sub&gt;50&lt;/sub&gt; of both fractions were 14.55&amp;plusmn;8.62 and 7.12&amp;plusmn;4.43 &amp;mu;g/mL respectively. However, Its were very weak compared to those of cancer medicine (Doxorubicin) with the IC&lt;sub&gt;50&lt;/sub&gt; was 0.04&amp;plusmn;0.02 &amp;mu;g/mL. Potential fractions were not toxic against Vero cells with IS&amp;gt;10. The active compounds in those fractions were alkaloid and terpenoid. &lt;strong&gt;Conclusion:&lt;/strong&gt; Chloroform extract of the &lt;em&gt;D. bulbifera&lt;/em&gt; leaves had the highest cytotoxic effect on T47D cells. Potential fractions were not toxic against Vero cells. The active compounds in those fractions were alkaloid and terpenoid.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">33</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rinto Muhammad Nur&lt;sup&gt;1&lt;/sup&gt;, Laurentius Hartanto Nugroho&lt;sup&gt;2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Fisheries and Marine Science, Universitas Pasifik Morotai, Jln. Siswa Darame, Kec. Morotae Selatan, Kab. Morotae, Maluku Utara, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Biology, Universitas Gadjah Mada, Jln. Teknika Selatan, Sekip Utara, Yogyakarta, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Netty Suharty</style></author><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Dachriyanus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Activity of Ethanol Extract of Arbuscular Mycorrhizal Fungi Induced Ginger Rhizome on T47D Breast Cancer Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">AMF</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Ginger</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1133-1136</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; A study of investigate the cytotoxicity activity of ethanolic extract of ginger (&lt;em&gt;Zingiber officinale&lt;/em&gt; Rosc.) induced with arbuscular mycorrhizal fungi (AMF) against T47D cells line breast cancer have been conducted. &lt;strong&gt;Methods:&lt;/strong&gt; Cytotoxicity were determined using the &amp;ldquo;microtetrazolium (MTT) Assay&amp;rdquo;, by measuring the activity of mitochondrial dehydrogenase in living cells that have ability to convert pale yellow of dissolved MTT to purple formazan product. The extract used at various concentration (0.1, 1.0, 10 and 100 &amp;mu;g / mL. The level of cytotoxic actifity was determined by calculating the inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;) value that was based on the precentage of cell death after 24 h treatment with the extract. The change of cell morphology were observed by using inverted microscope. &lt;strong&gt;Results:&lt;/strong&gt; The statistic results proved that ethanol extract of AMF induced ginger rhizome could barriers T47D breast cancers significantly at concentrations of 10 &amp;mu;g / mL and 100 ug / mL, with IC&lt;sub&gt;50&lt;/sub&gt; value was 12.5 &amp;plusmn; 3.73 &amp;mu;g / mL. centration of 0.1 &amp;mu;g / mL, 1.0 &amp;mu;g / mL, 10 &amp;mu;g / mL and 100 mg / mL. Results of statistical analysis showed that the ethanol extract of ginger rhizome induced AMF at a concentration of 10 &amp;mu;g / mL and 100 &amp;mu;g / mL was able to inhibit the growth of breast cancer cells T47D significantly. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results showed the ethanol extract of AMF induced ginger rhizome was potential as herbal medicine for cancer-related ailments with IC&lt;sub&gt;50&lt;/sub&gt; value was 12.5 &amp;plusmn; 3.73 &amp;mu;g / mL.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1133</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Netty Suharty, Fatma Sri Wahyuni, Dachriyanus*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Faculty of Pharmacy, Andalas University, West Sumatra, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Micheylla Kusumaning Dewi</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Cut Raisya Zahira Zagloel</style></author><author><style face="normal" font="default" size="100%">Yully Astika Nugrahayning Aziza</style></author><author><style face="normal" font="default" size="100%">Kartika Dwi Kurniasari</style></author><author><style face="normal" font="default" size="100%">Baiq Kirana Dyahningrum Mandasari</style></author><author><style face="normal" font="default" size="100%">Riathul Masita</style></author><author><style face="normal" font="default" size="100%">Futihati Ruhama Zulfa</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Rista Putrianingsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Evaluation of Seaweed Gracilaria verrucosa for Cytotoxic Activity against Cervical HeLa Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Gracillaria verrucosa</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa cervical cancer cells</style></keyword><keyword><style  face="normal" font="default" size="100%">IC50 value</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1007-1011</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Seaweed macroalgae of &lt;em&gt;Gracilaria verrucosa &lt;/em&gt;has been known to have a potent anticancer activity, however the cytotoxicity against cervical cancer has not been explored further. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to utilize Indonesia&amp;rsquo;s marine resource which is focused on seaweed macroalgae G. verrucosa as a future anti-cervical cancer agent. &lt;strong&gt;Materials and Method:&lt;/strong&gt; Seaweed &lt;em&gt;G. verrucosa&lt;/em&gt; originated from Labuan Aji beach, Nusa Tenggara Barat, Indonesia, extracted, macerated, and fractionated into four organic solvents of different polarity, consisting of hexane, ethyl acetate, chloroform and ethanol. Then, the macroalgae extracts are diluted into 8 different concentrations. Afterwards,&lt;em&gt; in vitro&lt;/em&gt; anticancer activity evaluation of hexane, ethyl acetate, chloroform and ethanol extracts of &lt;em&gt;G. verrucosa&lt;/em&gt; against cervical HeLa cells were conducted by MTT cell proliferation assay. Triplo mechanism is also applied in this study to increase the accuracy of the results. The anticancer activity is measured using IC&lt;sub&gt;50&lt;/sub&gt; value. &lt;strong&gt;Results:&lt;/strong&gt; The four concentrated extracts &lt;em&gt;G. verrucosa &lt;/em&gt;showed cytotoxicity against cervical HeLa cells. The greatest anticancer activity is depicted by hexane extract with an IC&lt;sub&gt;50&lt;/sub&gt; of 14.94 &amp;mu;g/mL, followed by chloroform (IC&lt;sub&gt;50&lt;/sub&gt; 15.74 &amp;mu;g/mL), ethyl acetate (IC&lt;sub&gt;50&lt;/sub&gt; 16.18 &amp;mu;g/mL), and ethanol (IC&lt;sub&gt;50&lt;/sub&gt; 19.43 &amp;mu;g/mL). &lt;strong&gt;Conclusion:&lt;/strong&gt; Our results clearly indicate that hexane, ethanol, chloroform, and ethyl acetate extracts of seaweed &lt;em&gt;G. verrucosa&lt;/em&gt; can be further developed to be anti-cervical cancer agents, with hexane extract displaying the greatest cytotoxic effect.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1007</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Micheylla Kusumaning Dewi&lt;sup&gt;1&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2,3*&lt;/sup&gt;, Cut Raisya Zahira Zagloel&lt;sup&gt;1&lt;/sup&gt;, Yully Astika Nugrahayning Aziza&lt;sup&gt;1&lt;/sup&gt;, Kartika Dwi Kurniasari&lt;sup&gt;1&lt;/sup&gt;, Baiq Kirana Dyahningrum Mandasari&lt;sup&gt;1&lt;/sup&gt;, Riathul Masita&lt;sup&gt;1&lt;/sup&gt;, Futihati Ruhama Zulfa&lt;sup&gt;1&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;3&lt;/sup&gt;, Rista Putrianingsih&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Student, Department of Medical Chemistry, Faculty of Medicine University of Indonesia, Depok, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Cluster, Drug Discovery Division, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aswathy Jayasree Madanakumar</style></author><author><style face="normal" font="default" size="100%">Murugan Kumaraswamy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Purified Anthocyanin, its Elicitation from Cell Cultures of Begonia malabarica and Begonia rex-cultorum ‘Baby Rainbow’and it’s In vitro Cytotoxicity Analysis by MTT Assay</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthocyanin</style></keyword><keyword><style  face="normal" font="default" size="100%">Begonia</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell suspension.</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/523</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">553-558</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; According to recent statistics, cancer accounts about marked percentage of total deaths in the world, although there are many therapeutic approaches. Unfortunately, the cytotoxicity properties of most chemotherapy drug are nonspecific and therefore do not distinguish between normal healthy cells and tumor cells, these events have led to inappropriate and toxic therapeutic agents with a wide range of side effects. However, several experimental and epidemiological studies have suggested that fruits and vegetables are associated with low risk of various types of cancer. Anthocyanins are natural pigments that provide intense purple to red color in plants. Anthocyanin possess the ability to inhibit oxidative stress and to induce apoptosis in malignant cells, thus may prevent carcinogenesis. &lt;strong&gt;Methods:&lt;/strong&gt; Antiproliferative properties of purified anthocyanin extract from elicited cell suspension cultures of &lt;em&gt;Begonia malabarica&lt;/em&gt; and &lt;em&gt;Begonia rex-cultorum&lt;/em&gt; &amp;lsquo;Baby rainbow&amp;rsquo; was investigated in terms of MTT assay. Anthocyanin extracts were tested for their ability to inhibit the growth of HT29 (colon cancer cells), MG63 (Osteosarcoma), HeLa (Cervical cancer cells) and L929 (Mouse Fibroblast L929) cell lines. &lt;strong&gt;Results:&lt;/strong&gt; Cell viability decreased in a dose dependent manner in all the considered cell lines treated with anthocyanin extracts. The extract of &lt;em&gt;Begonia rex-cultorum&lt;/em&gt; &amp;lsquo;Baby rainbow&amp;rsquo; exhibited significant cytotoxic activity against all tumor cell lines than &lt;em&gt;Begonia malabarica&lt;/em&gt; extract. &lt;em&gt;Begonia malabarica&lt;/em&gt; and &lt;em&gt;Begonia rex-cultorum&lt;/em&gt; &amp;lsquo;Baby rainbow&amp;rsquo; anthocyanin extract exhibited the highest cytotoxicity towards HT29 and HeLa cell lines respectively. But, MG63 resulted in comparatively higher percentage of viability of cell lines at the same concentrations. The anthocyanin extract produced significant morphological alterations on cell lines in culture. Meanwhile, the extracts showed poor cytotoxicity against the normal cell line. &lt;strong&gt;Conclusion:&lt;/strong&gt; The morphological alteration of the treated cancer cells presented clear evidence of significant cytotoxicity of anthocyanin extracts of both Begonias in all the three cell lines. Thus, anthocyanin may act as chemopreventive agents for various cancer cell lines.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">553</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aswathy Jayasree Madanakumar, Murugan Kumaraswamy&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Plant Biochemistry and Molecular Biology Laboratory, Department of Botany, University College, Trivandrum, 695 034, Kerala, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shenai Ashwini</style></author><author><style face="normal" font="default" size="100%">Devaraj Ezhilarasan</style></author><author><style face="normal" font="default" size="100%">Roy Anitha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Caralluma fimbriata</style></keyword><keyword><style  face="normal" font="default" size="100%">COLO 320 cell line</style></keyword><keyword><style  face="normal" font="default" size="100%">Colonic cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/301</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">204-207</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The present study was designed to examine the cytotoxic effects of ethanolic leaf extract of &lt;em&gt;Caralluma fimbriata&lt;/em&gt; in the COLO 320 cell line. &lt;strong&gt;Materials and Method:&lt;/strong&gt; The anti-proliferative effects were evaluated using the MTT assay. The COLO 320 cells were treated with different concentrations of the leaf extract of &lt;em&gt;Caralluma&lt;/em&gt; (100 &amp;ndash; 300 &amp;mu;g/ml) for 24 h. The cell viability and IC&lt;sub&gt;50&lt;/sub&gt; was calculated from the cytotoxicity. The morphology of the &lt;em&gt;Caralluma&lt;/em&gt; treated cells, control, and positive control were observed under reverse phase inverted microscope.&lt;strong&gt; Result:&lt;/strong&gt; The &lt;em&gt;C. fimbriata&lt;/em&gt; ethanolic leaf extract showed dose dependant increase in cytotoxicity in COLO 320 human colon cancer cells. The maximum cytotoxic effect was noticed with maximum dose used in this study i.e., 300 &lt;em&gt;&amp;mu;&lt;/em&gt;g with an IC&lt;sub&gt;50&lt;/sub&gt; value of 233.87 &lt;em&gt;&amp;mu;&lt;/em&gt;g. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study shows that the ethanolic leaf extract of &lt;em&gt;Caralluma fimbriata&lt;/em&gt; is capable of reducing cell proliferation by inducing cytotoxicity of COLO 320 cells.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">204</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shenai Ashwini, Devaraj Ezhilarasan, Roy Anitha* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha University, Chennai-600 077, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arunodaya Hosahalli Sumithregowda</style></author><author><style face="normal" font="default" size="100%">Krishna Venkatarangaiah</style></author><author><style face="normal" font="default" size="100%">Kumaraswamy Malleshappa Honnenahally</style></author><author><style face="normal" font="default" size="100%">Vinaykumar Nagenahalli Manjunath</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity and Oral Acute Toxicity Studies of Litsea glutinosa C. B (ROB) Stem Bark Ethanol Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast adenocarcinoma cell line</style></keyword><keyword><style  face="normal" font="default" size="100%">Haematology.</style></keyword><keyword><style  face="normal" font="default" size="100%">Litsea glutinosa</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/191</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">880-886</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Litsea glutinosa&lt;/em&gt; (Lauraceae) stem bark is widely used in folk medicine as a hepatoprotective, anti-diarrheal and anti-dysenteric drug but there is a lack of information about its toxicity. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate cytotoxicity and acute toxicity of the stem bark ethanol extract (BEE). &lt;strong&gt;Materials and Methods:&lt;/strong&gt; &lt;em&gt;In vitro&lt;/em&gt; cytotoxicity of BEE was measured against breast adenocarcinoma, prostate, and colon carcinoma cell lines. In the acute toxicity tests, rats received oral doses of BEE as 1000, 2000, and 3000 mg/kg body weight. Mortality, signs of toxicity, body weight, food consumption, and gross findings were observed for 14 days. Blood samples were collected from anesthetized animals and used for hematological and biochemical parameters. Histopathological study was performed using liver and kidney samples. &lt;strong&gt;Results:&lt;/strong&gt; The BEE does not show significant cytotoxic effect against the tested cell lines up to the range from 5 to 320 &amp;mu;g/ml. In acute toxicity study, also lethality was not observed up to 3000 mg/kg b.w. No significant differences were noticed in body and organ weights and histopathology examinations between the control and treated groups. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study authenticates stem BEE may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and evidences the medicinal use of this plant in folk medicine.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">880</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arunodaya Hosahalli Sumithregowda, Krishna Venkatarangaiah&lt;sup&gt;*&lt;/sup&gt;, Kumaraswamy Malleshappa Honnenahally, Vinaykumar Nagenahalli Manjunath &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of PG Studies and Research in Biotechnology, Kuvempu University, Shankaraghatta 577 451, Shivamogga, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rohin Mohd Adzim Khalili</style></author><author><style face="normal" font="default" size="100%">Jumli Mimie Noratiqah</style></author><author><style face="normal" font="default" size="100%">Ridzwan Norhaslinda</style></author><author><style face="normal" font="default" size="100%">Abd Hadi Norhayati</style></author><author><style face="normal" font="default" size="100%">Baig Atif Amin</style></author><author><style face="normal" font="default" size="100%">Arshad Roslan</style></author><author><style face="normal" font="default" size="100%">A. Latif Ahmad Zubaidi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity Effect and Morphological Study of Different Duku(Lansium domesticum corr.) Extract towards Human Colorectal Adenocarcinoma Cells Line (HT-29)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-proliferative effect</style></keyword><keyword><style  face="normal" font="default" size="100%">colorectal cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">IC50 value.</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">polarity extracts</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/172</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">757-761</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Lansium domesticum&lt;/em&gt; corr. is a member of the family Meliaceae, and known locally as duku and has been used traditionally in the prevention and treatment of various illness. &lt;strong&gt;Aim:&lt;/strong&gt; To study the cytotoxic effect and morphological changes of human colorectal adenocarcinoma cells (HT-29) treated with different duku &lt;em&gt;(Lansium domesticum&lt;/em&gt; corr.) extracts. &lt;strong&gt;Methods:&lt;/strong&gt; The &lt;em&gt;L.domesticum&lt;/em&gt; corr. fruit extracts were processed involving three different solvents; methanol, ethanol and ethyl acetate. HT-29 cell lines were treated with different concentrations of &lt;em&gt;L. domesticum&lt;/em&gt; corr. (0-100 &amp;mu;g/ml) extracts for a total of 24, 48 and 72 hours. Cytotoxicity of cells line was determined by using MTT assay as per IC&lt;sub&gt;50&lt;/sub&gt; values. &lt;strong&gt;Results:&lt;/strong&gt; Methanol extract of &lt;em&gt;L. domesticum&lt;/em&gt; corr. showed IC&lt;sub&gt;50&lt;/sub&gt; value at 6.79 &amp;plusmn; 0.00 &amp;mu;g/ml and 50.0 &amp;plusmn; 0.00 &amp;mu;g/ml respective, while ethyl acetate extract of L. domesticum corr. reached IC&lt;sub&gt;50&lt;/sub&gt; value at 86.00 &amp;plusmn; 0.08 &amp;mu;g/ml, and 96.0 &amp;plusmn; 0.12 &amp;mu;g/ml. There was no IC&lt;sub&gt;50&lt;/sub&gt; value of ethanol extract from &lt;em&gt;L.domesticum&lt;/em&gt; corr. Only methanol extract showed toxicity towards HT-29 cells line. &lt;strong&gt;Conclusion:&lt;/strong&gt; To the best of our knowledge, this is the first repeat the exploring the effect of duku (&lt;em&gt;L. domesticum&lt;/em&gt; corr.) extract on HT-29 cells line.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">757</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Rohin Mohd Adzim Khalili, Jumli Mimie Noratiqah, Ridzwan Norhaslinda, Abd Hadi Norhayati, Baig Atif Amin, Arshad Roslan, A. Latif Ahmad Zubaidi&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Gong Badak Campus, Hafsah Block, 21300 Kuala Nerus, Terengganu Darul Iman, MALAYSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Badarinath Druvarao Kulkarni</style></author><author><style face="normal" font="default" size="100%">Samim Sultana</style></author><author><style face="normal" font="default" size="100%">Mayuri Bora</style></author><author><style face="normal" font="default" size="100%">Ishita Dutta</style></author><author><style face="normal" font="default" size="100%">Padmaa Milaap Paarakh</style></author><author><style face="normal" font="default" size="100%">Vedamurthy Ankala Basappa.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Cytotoxicity Studies of Zn (Zinc) Nanoparticles Synthesized from Abutilon indicum L. against Human Cervical Cancer (HeLa) Cell Lines.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Abutilon indicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Cervical cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Zn nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">127-131</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The Zn nanoparticles synthesized from the plant sources are ecofriendly and are potent anticancer agents. &lt;strong&gt;Objective&lt;/strong&gt;: The objective of the present work was to evaluate &lt;em&gt;In vitr&lt;/em&gt;o cytotoxic activity of Zn nanoparticles green synthezised from &lt;em&gt;Abutilon indicu&lt;/em&gt;m extract against HeLa cell lines (cervical cancer). &lt;strong&gt;Methods:&lt;/strong&gt; The aqueous extract is prepared by cold extraction (maceration) using water as a solvent. Phytochemical analysis was done by using the standard procedures. Aqueous extract of &lt;em&gt;A. indicum&lt;/em&gt; was used for synthesis of Zn nanoparticles. The nanoparticles were characterized by UV-Visible spectrometry and Scanning electron microscopy (SEM) techniques. &lt;em&gt;In vitro&lt;/em&gt; cytotoxicity studies of Zn nanoparticles were done by MTT assay using HeLa cell lines. &lt;strong&gt;Results:&lt;/strong&gt; The preliminary phytochemical results revealed that the aqueous extract of &lt;em&gt;A. indicum&lt;/em&gt; contains broad spectrum of secondary metabolites like Tannins, Saponins, Glycosides, Flavonoids, Anthroquinones, Terpenoids and Steroids. The U.V spectrophotometeric analysis of Zn nanoparticles displayed maximum absorption at 270 nm and scanning electron microscopic studies showed that the nanoparticles size ranges from 50-500 nm. The MTT assay results revealed that the of Zn nanoparticles exhibits potent cytotoxicity against HeLa cell lines with IC&lt;sub&gt;50&lt;/sub&gt; value of 45.82 &amp;mu;g/ml. &lt;strong&gt;Conclusion:&lt;/strong&gt; Thus the present study concludes that Zn nanoparticles can be used as a potent drug in alternative therapy for treating the cervical cancer patients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">127</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Badarinath Druvarao Kulkarni&lt;sup&gt;1&lt;/sup&gt;, Samim Sultana&lt;sup&gt;2&lt;/sup&gt;, Mayuri Bora&lt;sup&gt;2&lt;/sup&gt;, Ishita Dutta&lt;sup&gt;2&lt;/sup&gt;, Padmaa Milaap Paarakh&lt;sup&gt;3&lt;/sup&gt;, Vedamurthy Ankala Basappa&lt;sup&gt;1&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology and Microbiology, Karnatak University, Dharwad, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, The Oxford College of Science, Bangalore, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, The Oxford College of Pharmacy, Bangalore-560 068, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Dini Hara Triastuti</style></author><author><style face="normal" font="default" size="100%">Helmi Arifin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity Study of Ethanol Extract of the Leaves of Asam Kandis (Garcinia cowa Roxb.) on T47D Breast Cancer Cell line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asam kandis</style></keyword><keyword><style  face="normal" font="default" size="100%">Beast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia cowa Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">369-371</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To investigate the cytotoxic effect of ethanolic extract of the leaves of asam kandis (Garcinia cowa Roxb.) against T47D breast cancer cells. &lt;strong&gt;Methods:&lt;/strong&gt; The cytotoxicity of ethanol extract was carried out by measuring the activity of mitochondrial dehydrogenase in living cells that have ability to convert dissolved MTT pale yellow to purple formazan product. The extract was added at various concentrations (0.1, 1, 10 and 100 &amp;mu;g/mL). The level of cytotoxicity was determined by calculating the IC50 value that was based on the percentage of the cell death after 24 hours treatment with the extract. Cell morphological changes were observed by using inverted microscope. &lt;strong&gt;Results:&lt;/strong&gt; The IC50 value showed that ethanol extract of leaves of asam kandis could resist T47D breast cancer cells with IC50 6.13 &amp;plusmn; 3.51 &amp;mu;g/mL. The statistic results proved that ethanol extract of the leaves of asam kandis could inhibit the growth of T47D breast cancer cells significantly at concentrations of 10 &amp;mu;g/mL and 100 &amp;mu;g/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results suggest that ethanol extract of the leaves of asam kandis was potential source of herbal medicine for cancer-related ailments.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">369</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Fatma Sri Wahyuni*, Dini Hara Triastuti and Helmi Arifin&lt;/strong&gt; Department of Pharmacy, Faculty of Pharmacy, Andalas University, Kampus Limau Manis, Padang, Indonesia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kiruthika Dhanraj</style></author><author><style face="normal" font="default" size="100%">Renuka Saravanan</style></author><author><style face="normal" font="default" size="100%">Sheik Abdulla Shahul Hameed</style></author><author><style face="normal" font="default" size="100%">Sivakumar Ramalingam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anticancer Potential of Vitus vinifera Seed Against Breast Cancer Cells - MDA-MB-231</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA-MB-231</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitus vinifera seed</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1064-1071</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The aim of the present research is to evaluate the anti-cancer effect of &lt;em&gt;Vitus vinifera &lt;/em&gt;seed on MDA-MB-231 cell line. &lt;strong&gt;Methods: &lt;/strong&gt;The &lt;em&gt;Vitus vinifera &lt;/em&gt;(Grape) seed were dried, powdered and subjected to methanol, chloroform and ethyl acetate extraction by cold maceration followed by preliminary phytochemical screening. The extracts of &lt;em&gt;Vitus vinifera &lt;/em&gt;seed were subjected to assess anti-oxidant status, anti-proliferative activity by MTT assay, GC-MS analysis and apoptotic effect by determining LDH activity on MDA-MB-231. &lt;strong&gt;Results: &lt;/strong&gt;Results indicated that methanolic extract of grape seed showed appreciable anti-oxidant and anti-cancer potential compared with other two extracts. GC-MS mass spectrum of methanolic extract of seed revealed the presence of Dotriacontane, Linoleic acid and Decanoic acid ethyl ester, 1,2,3, propenetriol, monocetate, and Dichloro methyl propane sulfone were detected. &lt;strong&gt;Conclusion: &lt;/strong&gt;The data obtained in this work could be useful as a chemical standard in checking the genuineness of this plant source. Data of the results further depicted that the selected traditional &lt;em&gt;Vitus vinifera &lt;/em&gt;seed could be used not only as a potential anti-cancer and good antioxidant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1064</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kiruthika Dhanraj, Renuka Saravanan, Sheik Abdulla Shahul Hameed, Sivakumar Ramalingam*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Chemistry and Biosciences, SASTRA Deemed to be University, Srinivasa Ramanujam Centre, Kumbakonam 612001, Tamil Nadu, INDIA.&lt;/p&gt;
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