<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meri Susanti</style></author><author><style face="normal" font="default" size="100%">Sanusi Ibrahim</style></author><author><style face="normal" font="default" size="100%">Yahdiana Harahap</style></author><author><style face="normal" font="default" size="100%">Dachriyanus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison between High Performance Thin Layer Chromatography and High Performance Liquid Chromatography Methods for Determination of Rubraxanthone in the Stem Bark Extract of Garcinia cowa Roxb</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Garcinia cowa Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">High Performance Liquid Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">High performance Thin layer Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">rubraxanthone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s42-s47</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To develop simple, rapid, accurate methods for determination of rubraxanthone in the stem bark extract of &lt;em&gt;Garcinia cowa&lt;/em&gt; using High Performance Thin Layer Chromatography (HPTLC) and High Performance Liquid Chromatography (HPLC). &lt;strong&gt;Methods:&lt;/strong&gt; The HPTLC method was performed on aluminum plate precoated with silica gel 60 F254 using Chloroform: Ethyl acetate: Methanol: Formic acid (88:2:2:8) as a developing system. Quantification was achieved using densitometric measurements at 243 nm. The HPLC method involved a 5 &amp;mu;m C18 column and an isocratic solvent using 0.4% formic acid: methanol (12:88) with a flow rate 1 mL minute-&lt;sup&gt;1&lt;/sup&gt;. Quantitation was also achieved with ultraviolet detection at 243 nm based on peak area. All necessary validation tests for both methods were done for their comparison. The results obtained by these two different quantification methods were compared by Tukey&amp;rsquo;s-test. &lt;strong&gt;Results:&lt;/strong&gt; Both assays provided good linearity, accuracy, precision, specificity and limits of detection and quantitation for determination of rubraxanthone in The Stem Bark extract of &lt;em&gt;G. cowa.&lt;/em&gt; &lt;strong&gt;Conclusion:&lt;/strong&gt; Both methods revealed reasonable validation parameters concerning linearity, accuracy, precision, specificity and limits of detection and quantitation. A statistical comparison of the quantitative analysis of rubraxanthone in extract did not show any statistically significant difference between two analysis methods. As both methods were found to be equal, they therefore can be used for the analysis of rubraxanthone in the Stem Bark extract of &lt;em&gt;G. cowa&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s42</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Meri Susanti&lt;sup&gt;1&lt;/sup&gt;, Sanusi Ibrahim&lt;sup&gt;2&lt;/sup&gt;, Yahdiana Harahap&lt;sup&gt;3&lt;/sup&gt;, Dachriyanus&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Andalas University, West Sumatra, 25163, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt; 2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, West Sumatra, 25163, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, 16424, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Dini Hara Triastuti</style></author><author><style face="normal" font="default" size="100%">Helmi Arifin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity Study of Ethanol Extract of the Leaves of Asam Kandis (Garcinia cowa Roxb.) on T47D Breast Cancer Cell line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asam kandis</style></keyword><keyword><style  face="normal" font="default" size="100%">Beast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia cowa Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">369-371</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To investigate the cytotoxic effect of ethanolic extract of the leaves of asam kandis (Garcinia cowa Roxb.) against T47D breast cancer cells. &lt;strong&gt;Methods:&lt;/strong&gt; The cytotoxicity of ethanol extract was carried out by measuring the activity of mitochondrial dehydrogenase in living cells that have ability to convert dissolved MTT pale yellow to purple formazan product. The extract was added at various concentrations (0.1, 1, 10 and 100 &amp;mu;g/mL). The level of cytotoxicity was determined by calculating the IC50 value that was based on the percentage of the cell death after 24 hours treatment with the extract. Cell morphological changes were observed by using inverted microscope. &lt;strong&gt;Results:&lt;/strong&gt; The IC50 value showed that ethanol extract of leaves of asam kandis could resist T47D breast cancer cells with IC50 6.13 &amp;plusmn; 3.51 &amp;mu;g/mL. The statistic results proved that ethanol extract of the leaves of asam kandis could inhibit the growth of T47D breast cancer cells significantly at concentrations of 10 &amp;mu;g/mL and 100 &amp;mu;g/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results suggest that ethanol extract of the leaves of asam kandis was potential source of herbal medicine for cancer-related ailments.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">369</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Fatma Sri Wahyuni*, Dini Hara Triastuti and Helmi Arifin&lt;/strong&gt; Department of Pharmacy, Faculty of Pharmacy, Andalas University, Kampus Limau Manis, Padang, Indonesia&lt;/p&gt;
</style></auth-address></record></records></xml>