<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Danae Liviac</style></author><author><style face="normal" font="default" size="100%">Paola Raunelli</style></author><author><style face="normal" font="default" size="100%">Rafael Alvis</style></author><author><style face="normal" font="default" size="100%">Silvio Puente</style></author><author><style face="normal" font="default" size="100%">Ivan Best</style></author><author><style face="normal" font="default" size="100%">Oscar Reategui</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis, In vitro Antioxidant Capacity and Toxicity Assessment of Copaifera paupera Oleoresin</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antigenotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Comet assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Copaifera paupera</style></keyword><keyword><style  face="normal" font="default" size="100%">Micronucleus test</style></keyword><keyword><style  face="normal" font="default" size="100%">Oleoresin</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">374-378</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The present study was taken to determine the phytochemical analysis, the antioxidant activity &lt;em&gt;in vitro&lt;/em&gt; (FRAP and TBARS methodologies), the oral acute toxicity and antigenotoxicity of the oleoresin &lt;em&gt;Copaifera paupera&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; The oleoresin was tested for &lt;em&gt;in vivo&lt;/em&gt; cytoprotective capacity using the Micronucleus Test and the Comet Assay in mice bone marrow cells and mice erythrocytes cells, respectively.&lt;strong&gt; Results:&lt;/strong&gt; The oleoresin had low levels of total flavonoids and phenol content and also of antioxidant capacity. Orally, the LD50 appeared to be &amp;gt; 5000 mg/kg (no toxic or low toxic). The results showed all the doses evaluated (180 360, 720 and 1440 mg/kg) antigenotoxic effect by reduce the DNA damage induced by cyclophosphamide, being a 100 % DNA damage reduction at the highest dose evaluated. &lt;strong&gt;Conclusion:&lt;/strong&gt; According to the Micronucleus test, the oleoresin Copaifera paupera had the ability of increase the cell proliferation despite the exposition of cyclophosphamide. (abstract is not arranged properly, improper sentences)&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">374</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Danae Liviac&lt;sup&gt;1&lt;/sup&gt;, Paola Raunelli&lt;sup&gt;2&lt;/sup&gt;, Rafael Alvis&lt;sup&gt;1&lt;/sup&gt;, Silvio Puente&lt;sup&gt;3&lt;/sup&gt;, Ivan Best&lt;sup&gt;2,4,5&lt;/sup&gt;, Oscar Reategui&lt;sup&gt;3* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Cellular and Molecular Biology. Universidad Científica del Sur, Panamericana Sur Km 19, Lima, PERU.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Científica del Sur, Panamericana Sur Km 19, Lima, PERU.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;School of Agroforestry Engineering. Universidad Científica del Sur, Panamericana Sur Km 19, Lima, PERU.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Hersil S. A. Laboratorios Industriales Farmacéuticos, Lima, PERU.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Grupo de Ciencia, Tecnología e Innovación en Alimentos, Universidad San Ignacio de Loyola, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan</style></author><author><style face="normal" font="default" size="100%">Gunasekar Ramya</style></author><author><style face="normal" font="default" size="100%">Madhusudhanan Gogulramnath</style></author><author><style face="normal" font="default" size="100%">Rajarajeswaran Jayakumar</style></author><author><style face="normal" font="default" size="100%">M.S. Kanthimathi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of cytotoxic, DNA protecting and LPS induced MMP-9 down regulation activities of Plectranthus amboinicus (Lour) Spreng. essential oil</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antigenotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">RT- PCR.</style></keyword><keyword><style  face="normal" font="default" size="100%">Zymogram</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">32-36</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour) Spreng is a known medicinal plant used in Siddha and Ayurveda medicines in India. It has enormous medicinal potential to treat various diseases. &lt;strong&gt;Methods:&lt;/strong&gt; The present study focused on the use of essential oil obtained from the leaves of Plectranthusamboinicusto test cytotoxicity against breast (MCF-7) and colorectal (HT-29) cancer cell lines, to protect DNA from H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; induced genotoxicity through comet assay and to treat inflammation in lipopolysaccharide (LPS) induced over expression of matrix metalloproteinase-9 (MMP-9) in human peripheral blood mononuclear cells (PBMCs) by gelatin zymogram and inhibition at transcriptional level confirmed using RT-PCR (reverse transcriptase polymerase chain reaction). &lt;strong&gt;Results:&lt;/strong&gt; Cytotoxicity of essential oil against MCF-7 and HT-29 cancer cell lines revealed the IC&lt;sub&gt;50&lt;/sub&gt; values of 53 &amp;plusmn; 0.01 and 87 &amp;plusmn; 0.01 &amp;mu;g/mL respectively. At 200 &amp;mu;g/mL essential oil protected against 75% of DNA damage in 3T3-L1 fibroblast cells. Essential oil showed significant reduction in production of MMP-9 in a concentration dependent manner. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall, the results showed that essential oil of &lt;em&gt;P. amboinicus&lt;/em&gt; is a potent bioactive substance and it could be used in herbal medicine preparations.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramaraj Thirugnanasampandan&lt;sup&gt;a,*&lt;/sup&gt;, Gunasekar Ramya&lt;sup&gt;a&lt;/sup&gt;, Madhusudhanan Gogulramnath&lt;sup&gt;a&lt;/sup&gt;, Rajarajeswaran Jayakumar&lt;sup&gt;b&lt;/sup&gt;, M.S. Kanthimathi&lt;sup&gt;b&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Laboratory of Plant Tissue Culture and Molecular Bioprospection, PG and Research Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan</style></author><author><style face="normal" font="default" size="100%">Gunasekar Ramya</style></author><author><style face="normal" font="default" size="100%">Madhusudhanan Gogulramnath</style></author><author><style face="normal" font="default" size="100%">Rajarajeswaran Jayakumar</style></author><author><style face="normal" font="default" size="100%">M.S. Kanthimathi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of cytotoxic, DNA protecting and LPS induced MMP-9 down regulation activities of Plectranthus amboinicus (Lour) Spreng. essential oil.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antigenotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">RT- PCR</style></keyword><keyword><style  face="normal" font="default" size="100%">Zymogram</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">32-36</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour) Spreng is a known medicinal plant used in Siddha and Ayurveda medicines in India. It has enormous medicinal potential to treat various diseases. &lt;strong&gt;Methods:&lt;/strong&gt; The present study focused on the use of essential oil obtained from the leaves of &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; to test cytotoxicity against breast (MCF-7) and colorectal (HT-29) cancer cell lines, to protect DNA from H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; induced genotoxicity through comet assay and to treat inflammation in lipopolysaccharide (LPS) induced over expression of matrix metalloproteinase-9 (MMP-9) in human peripheral blood mononuclear cells (PBMCs) by gelatin zymogram and inhibition at transcriptional level confirmed using RT-PCR (reverse transcriptase polymerase chain reaction). &lt;strong&gt;Results:&lt;/strong&gt; Cytotoxicity of essential oil against MCF-7 and HT-29 cancer cell lines revealed the IC50 values of 53 &amp;plusmn; 0.01 and 87 &amp;plusmn; 0.01&amp;mu;g/mL respectively. At 200 &amp;mu;g/mL essential oil protected against 75% of DNA damage in 3T3-L1 fibroblast cells. Essential oil showed significant reduction in production of MMP-9 in a concentration dependent manner. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall, the results showed that essential oil of &lt;em&gt;P. amboinicus&lt;/em&gt; is a potent bioactive substance and it could be used in herbal medicine preparations.&lt;br /&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt; Essential oil , Cytotoxicity , Antigenotoxicity, Zymogram, RT- PCR.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan, Gunasekar Ramya, Madhusudhanan Gogulramnath, Rajarajeswaran Jayakumar, M.S. Kanthimathi</style></custom1><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramaraj Thirugnanasampandan&lt;sup&gt;a,*&lt;/sup&gt;, Gunasekar Ramya&lt;sup&gt;a&lt;/sup&gt;, Madhusudhanan Gogulramnath&lt;sup&gt;a&lt;/sup&gt;, Rajarajeswaran Jayakumar&lt;sup&gt;b&lt;/sup&gt;, M.S. Kanthimathi&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;b&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Laboratory of Plant Tissue Culture and Molecular Bioprospection, PG and Research Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.&lt;/p&gt;</style></auth-address></record></records></xml>