<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Novi Fajar Utami</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Hayun Hayun</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Syamsu Nur</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Bacterial Enzymes on Reducing Chlorogenic Acid Levels in Cascara Robusta Coffee (Coffea canephora L.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bacillus subtilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cascara</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorogenic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">332-335</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Coffee skin by-products, namely cascara, have several benefits, namely can ward off free radicals, with the ability of cascara to ward off free radicals so that cascara can potentially prevent the emergence of cancer cells. Cascara contains active compounds caffeine 1.3%, chlorogenic acid 2.6%, and caffeic acid 1.6%. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to determine chlorogenic acid levels in decaffeinated robusta coffee (Coffea canephora L.) and see the influence of Bacillus subtilis bacteria on reducing chlorogenic acid levels. &lt;strong&gt;Methods:&lt;/strong&gt; The experiment was conducted from June to August 2022 in the Pharmacy Laboratory, Faculty of Mathematics and Natural Sciences, Universitas Pakuan, Indonesia. Cascara robusta coffee is fermented using Bacillus subtilis with a concentration of 6% and a time of 24 hours. After fermentation, the extraction is carried out using the UAE (Ultrasonic Assisted Extraction) method. The chlorogenic acid levels and zero control of cascara robusta coffee obtained were then analyzed using Statistical Package for the Social Science (SPSS) with the Paired sample t-test method previously carried out with normality test and homogeneity test first. &lt;strong&gt;Results:&lt;/strong&gt; The study found chlorogenic acid levels produced from cascara robusta coffee that had undergone decaffeination. Quantitative analysis of chlorogenic acid levels in cascara robusta coffee was carried out using HPLC mobile phase methanolwater (adjust Orthoposphat pH 2.4), flow rate 0.7 mL/minute, with an isocratic system of an average of 14.8597%. &lt;strong&gt;Conclusion:&lt;/strong&gt; Chlorogenic acid levels in robusta coffee cascara decaffeinated by microbial enzymes can affect chlorogenic acid levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">332</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Novi Fajar Utami&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1*&lt;/sup&gt;, Hayun Hayun&lt;sup&gt;3&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;4,5,6&lt;/sup&gt;, Syamsu Nur&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Phytochemistry and Pharmacognosy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Math and Science, Universitas Pakuan, Jl. Raya Pakuan 1 Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Pharmaceutical Chemistry, Almarisah Madani University, Makassar, South Sulawesi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Phimkun Aiyarakanchanakun</style></author><author><style face="normal" font="default" size="100%">Chanida Palanuvej</style></author><author><style face="normal" font="default" size="100%">Nijsiri Ruangrungsi</style></author><author><style face="normal" font="default" size="100%">Anuchit Phanumartwiwath</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Specifications, RP-HPLC Analysis of Chlorogenic Acid Content and Antioxidant Activity of Morus alba Linn. Leaves in Thailand</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorogenic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Morus alba</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic specification</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality control</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1186-1194</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Morus alba Linn. leaves have been widely used as herbal medicine with therapeutics and contain chlorogenic acid as a bioactive phenolic compound. &lt;strong&gt;Objective:&lt;/strong&gt; The present study aimed to conduct the pharmacognostic specifications of M. alba leaves and the method validation for quantification of chlorogenic acid content. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Macroscopic- and microscopic characteristics, physicochemical parameters combined with quantification of chlorogenic acid in &lt;em&gt;M. alba &lt;/em&gt;leaves collected from 15 sources throughout Thailand and their antioxidant activity were reported in this study. &lt;strong&gt;Results: &lt;/strong&gt;The physicochemical parameters of&lt;em&gt; M. alba&lt;/em&gt; leaves were determined by indicating water content (7.97 ± 0.35%), loss on drying (4.55 ± 0.21%), total ash (14.38 ± 0.25%), acid-insoluble ash (6.21 ± 0.37%), water-extractive value (16.14 ± 0.50%) and ethanol-extractive value (8.61 ± 0.39%). In addition, the chlorogenic acid contents in &lt;em&gt;M. alba&lt;/em&gt; leaves were found to be 0.4159 ± 0.1958 g/100g dry weight. The ethanolic leaf extracts exhibited their antioxidant activity with half-maximal inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;) values (326.09–467.55 μg/mL). &lt;strong&gt;Conclusion: &lt;/strong&gt;This study showed the establishment of pharmacognostic study of&lt;em&gt; M. alba&lt;/em&gt; leaves and validation of the reversed-phase high-performance liquid chromatography (RPHPLC) quantitative analysis of their chlorogenic acid contents, which are applicable to be a reference for quality control and standardization of &lt;em&gt;M. alba&lt;/em&gt; leaves.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1186</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Phimkun Aiyarakanchanakun&lt;sup&gt;1&lt;/sup&gt;, Chanida Palanuvej&lt;sup&gt;1&lt;/sup&gt;, Nijsiri Ruangrungsi&lt;sup&gt;1,2&lt;/sup&gt;, Anuchit Phanumartwiwath&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;College of Public Health Sciences, Chulalongkorn University, Bangkok, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, College of Pharmacy, Rangsit University, Pathum Thani, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Adisya Miftah Syakfanaya</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Simultaneously Extraction of Caffeine and Chlorogenic Acid from Coffea canephora Bean using Natural Deep Eutectic Solvent-Based Ultrasonic Assisted Extraction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Caffeine</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorogenic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Coffea canephora</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural deep eutectic solvent</style></keyword><keyword><style  face="normal" font="default" size="100%">Ultrasonic assisted extraction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">267-271</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Background&lt;/strong&gt;: NADES is an alternative solvent in the extraction of metabolites from plants which has many environmental benefits, such as low toxicity, biodegradability, can dissolve polar and non-polar compounds, low costs and simple preparation. &lt;strong&gt;Objective&lt;/strong&gt;: This study aims to determine the effect of natural deep eutectic solvent-based ultrasonic-assisted extraction (NADES-UAE) on enrichment of caffeine and chlorogenic acid in extract from green coffee beans (&lt;em&gt;Coffea canephora&lt;/em&gt;).&lt;strong&gt; Methods:&lt;/strong&gt; The powders were extracted using NADES-UAE method in several types of extraction condition, including the composition of NADES, water addition in NADES and extraction time. Caffeine and chlorogenic acid content were analyzed using HPLC, reverse phase system and C18 ODS-3 column. &lt;strong&gt;Results&lt;/strong&gt;: The highest of caffeine and chlorogenic acid content was respectively, 7.89 mg/g and 28.62 mg/g (composition of NADES betaine: sorbitol [1:1.2] ratio and NADES-water addition [1:2] ratio for 30 min). &lt;strong&gt;Conclusion&lt;/strong&gt;: This research showed that the composition of NADES, extraction time and water addition are important parameter in extracting caffeine and chlorogenic acid content in green coffee beans.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">267</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Adisya Miftah Syakfanaya&lt;sup&gt;1&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;2&lt;/sup&gt;, Abdul Mun’im&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Master student at Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology- Toxicology, Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Associate Professor at Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, INDONESIA.&lt;/p&gt;
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