<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raphael de Oliveira Rodrigues</style></author><author><style face="normal" font="default" size="100%">Juliana Navarro Ueda Yaochite</style></author><author><style face="normal" font="default" size="100%">Milena Aguiar Braga</style></author><author><style face="normal" font="default" size="100%">Amanda Ribeiro de</style></author><author><style face="normal" font="default" size="100%">Sousa</style></author><author><style face="normal" font="default" size="100%">Greyce Luri Sasahara</style></author><author><style face="normal" font="default" size="100%">Said Gonçalves da Cruz Fonseca</style></author><author><style face="normal" font="default" size="100%">Thiago Dias de Vasconcelos Araújo</style></author><author><style face="normal" font="default" size="100%">Gilvandete</style></author><author><style face="normal" font="default" size="100%">Maria Pinheiro Santiago</style></author><author><style face="normal" font="default" size="100%">Leôncio Mesquita de Sousa</style></author><author><style face="normal" font="default" size="100%">Jarbas Lima de Carvalho</style></author><author><style face="normal" font="default" size="100%">Francisca Bruna Stefany Aires</style></author><author><style face="normal" font="default" size="100%">do Nascimento</style></author><author><style face="normal" font="default" size="100%">Hélio Vitoriano Nobre Júnior</style></author><author><style face="normal" font="default" size="100%">Aparecida Tiemi Nagao-Dias</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Anti-inflammatory Activities of Bauhinia ungulata L. (Fabaceae) on LPS-Stimulated RAW 264.7 Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bauhinia ungulata; RAW 264.7 cells; Lipopolysaccharide; Free radicals; Antioxidant activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">37-42</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present study aimed to investigate the antioxidant, immunomodulatory and antimicrobial activities of &lt;em&gt;Bauhinia ungulata&lt;/em&gt; L.&lt;strong&gt; Method:&lt;/strong&gt; A flavonoid-rich fraction was obtained from the &lt;em&gt;Bauhinia ungulata&lt;/em&gt; L stem, called the ethyl acetate fraction of &lt;em&gt;Bauhinia ungulata&lt;/em&gt; (FABU). The total antioxidant capacity of the FABU was determined through the phosphomolibdenium reduction method. For the evaluation of its antioxidant activity on a cell culture model, LPS-stimulated RAW 264.7 cells were treated with different concentrations of FABU and the reactive oxygen species (ROS), nitric oxide (NO), hydrogen peroxide (H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;) and thiobarbituric acid reactive substances (TBARS) production levels were measured. For the analysis of its immunomodulatory capacity, TNF-α, TGF-β and IL-10 levels were determined in the culture supernatant. In order to determinate the antimicrobial activity of FABU, antifungal and antibacterial susceptibility testing was performed against &lt;em&gt;Candida albicans&lt;/em&gt;, methicillinsensitive &lt;em&gt;Staphylococcus aureus,&lt;/em&gt; methicillin-resistant &lt;em&gt;Staphylococcus aureus&lt;/em&gt; and &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; strains. &lt;strong&gt;Result:&lt;/strong&gt; The FABU demonstrated neither significant antimicrobial activity nor immunodulatory capacity; on the other hand, its potential antioxidant activity was demonstrated by the phosphomolibdenium reduction assay. Also, FABU treatment inhibited the ROS, NO, H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; and TBARS levels in the supernatant of LPS-stimulated cells. &lt;strong&gt;Conclusion:&lt;/strong&gt; A significant reduction in the amount of reactive oxygen and nitrogen species (RONS) was observed, in addition to lipid peroxidation inhibition. Our data suggest that the FABU is a natural antioxidant complex that may interfere in the cascade of cell damage caused by free radicals and a promising potential drug in chronic disease models in which immunopathogenicity involves high levels of RONS.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">37</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Raphael de Oliveira Rodrigues&lt;sup&gt;1,*&lt;/sup&gt;, Juliana Navarro Ueda Yaochite&lt;sup&gt;1&lt;/sup&gt;, Milena Aguiar Braga&lt;sup&gt;1&lt;/sup&gt;, Amanda Ribeiro de Sousa&lt;sup&gt;1&lt;/sup&gt;, Greyce Luri Sasahara&lt;sup&gt;1&lt;/sup&gt;, Said Gonçalves da Cruz Fonseca&lt;sup&gt;2&lt;/sup&gt;, Thiago Dias de Vasconcelos Araújo&lt;sup&gt;2&lt;/sup&gt;, Gilvandete Maria Pinheiro Santiago&lt;sup&gt;2&lt;/sup&gt;, Leôncio Mesquita de Sousa&lt;sup&gt;3&lt;/sup&gt;, Jarbas Lima de Carvalho&lt;sup&gt;3&lt;/sup&gt;, Francisca Bruna Stefany Aires do Nascimento&lt;sup&gt;1&lt;/sup&gt;, Hélio Vitoriano Nobre Júnior&lt;sup&gt;1&lt;/sup&gt;, Aparecida Tiemi Nagao-Dias&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Analysis and Toxicology, Faculty of Pharmacy, Universidade Federal do Ceara (UFC), Rua Capitao Francisco Pedro 1210, 60430-370 Fortaleza, CE, BRAZIL.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacy, Universidade Federal do Ceara (UFC), Rua Capitao Francisco Pedro 1210, 60430-370 Fortaleza, CE, BRAZIL.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Organic and Inorganic Chemistry, Sciences Center, Universidade Federal do Ceara (UFC), Campus do Pici 12.200, 60021-940, Fortaleza, CE, BRAZIL.&lt;/p&gt;
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