<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marco Mesia Guevara</style></author><author><style face="normal" font="default" size="100%">Jesus Rojas Jaimes</style></author><author><style face="normal" font="default" size="100%">Luis Castañeda Pelaez</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Proliferative effect of Dracontium spruceanum on Leishmania</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cell viability</style></keyword><keyword><style  face="normal" font="default" size="100%">Cutaneous Leishmaniasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Dracontium spruceanum</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucantime</style></keyword><keyword><style  face="normal" font="default" size="100%">Leishmania</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">683-687</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Leishmaniasis&lt;/em&gt;, transmitted by sandflies and caused by protozoa of the genus Leishmania, primarily presents in its cutaneous form. Difficulties in diagnosis and the adverse effects of conventional treatments have driven the search for alternatives, such as &lt;em&gt;Dracontium spruceanum&lt;/em&gt; (&quot;sacha jergón&quot;), an Amazonian plant containing compounds with potential activity against &lt;em&gt;Leishmania&lt;/em&gt; spp., whose efficacy still requires scientific validation. &lt;strong&gt;Objective: &lt;/strong&gt;To determine the effect of the aqueous extract of &lt;em&gt;Dracontium spruceanum &lt;/em&gt;against &lt;em&gt;Leishmania&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Detection of &lt;em&gt;Leishmania &lt;/em&gt;(Viannia) spp. kDNA was performed by PCR using primers MP1-L and MP3-H, with LTB-300 (L. (V.) braziliensis) and DNAfree water as controls. Promastigotes were isolated from cutaneous lesion scrapings and cultured in biphasic medium, achieving differentiation into axenic amastigotes in Schneider medium, with pH 4.7 as the optimal condition for complete conversion. Plant material of &lt;em&gt;Dracontium spruceanum&lt;/em&gt; collected in Ucayali (Peru) was processed to obtain an aqueous extract (100 mg/mL). The antiparasitic activity of the extract was evaluated by the MTT assay against promastigotes and amastigotes, using Glucantime as a positive control. Data obtained were analyzed by ANOVA, considering p-values &amp;lt; 0.05 as significant. &lt;strong&gt;Results: &lt;/strong&gt;In &lt;em&gt;in vitro &lt;/em&gt;assays with &lt;em&gt;Leishmania &lt;/em&gt;sp., administration of Glucantime (25 mg/mL) produced a significant decrease in cell viability of promastigotes (71%) and axenic amastigotes (38%) compared to the control group. Conversely, the aqueous extract of &lt;em&gt;Dracontium spruceanum&lt;/em&gt; (8.33 mg/mL) caused a significant increase in promastigote (160%) and amastigote (179%) viability, indicating a stimulatory effect on parasite growth (p &amp;lt; 0.05). &lt;strong&gt;Discussion and conclusion: &lt;/strong&gt;The in vitro effect of the aqueous extract of &lt;em&gt;Dracontium spruceanum&lt;/em&gt; on promastigotes and axenic amastigotes of &lt;em&gt;Leishmania &lt;/em&gt;sp. was investigated. Unlike Glucantime, which significantly decreased parasite viability, the extract consistently promoted proliferation in both forms. This result, uncommon in medicinal plant studies, could be linked to the presence of ceramides and cerebrosides, compounds in the genus Dracontium previously associated with mitogenic activity. Additional dose-response studies and phytochemical analysis are needed to identify the active compounds and clarify their mechanism of action.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">683</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Marco Mesía Guevara&lt;sup&gt;1&lt;/sup&gt;, Jesús Rojas Jaimes&lt;sup&gt;2&lt;/sup&gt;, Luis Castañeda Pelaez&lt;sup&gt;2*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Ciencias de la Salud, Universidad San Ignacio de Loyola, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias de la Salud, Universidad Privada del Norte, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raden Anita Indriyanti</style></author><author><style face="normal" font="default" size="100%">Eko Fuji Ariyanto</style></author><author><style face="normal" font="default" size="100%">Hermin Aminah Usman</style></author><author><style face="normal" font="default" size="100%">Ristaniah Rose Effendy</style></author><author><style face="normal" font="default" size="100%">Diah Dhianawaty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synergistic Effect of Imperata cylindrica Root Extract and Erlotinib on A549 Lung Cancer Cell Viability</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A549</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell viability</style></keyword><keyword><style  face="normal" font="default" size="100%">Erlotinib</style></keyword><keyword><style  face="normal" font="default" size="100%">Imperata cylindrica</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">656-659</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Erlotinib is typically used to treat lung adenocarcinoma and Imperata cylindrica extract has been shown to exert anti-cancer effects in various human cancer cell lines. Therefore, this study evaluated the combined anticancer effects of Imperata cylindrica ethanol root extract and erlotinib on the A549 lung cancer cell line. &lt;strong&gt;Method:&lt;/strong&gt; The A-549 lung cancer cell line was treated with various combinations of 1/2 IC50, 3/8 IC50, 1/4 IC50, and 1/8 IC50 of I.cylindrica root ethanol extract and erlotinib for 48 hours. Cell viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, analyzed and interpreted using CompuSyn software and a normalized isobologram curve. &lt;strong&gt;Result:&lt;/strong&gt; Of the sixteen combinations, eleven combinations acted synergistically, four were additive, and one was in the antagonist zone. &lt;strong&gt;Conclusion:&lt;/strong&gt; The combination of I. cylindrica root ethanol extract and erlotinib act synergistically to decrease A549 lung cancer cell viability, therefore they are potential lung cancer therapeutics.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">656</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Raden Anita Indriyanti&lt;sup&gt;1&lt;/sup&gt;*, Eko Fuji Ariyanto&lt;sup&gt;2&lt;/sup&gt;, Hermin Aminah Usman&lt;sup&gt;3&lt;/sup&gt;, Ristaniah Rose Effendy&lt;sup&gt;4&lt;/sup&gt;, Diah Dhianawaty&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Bandung Islamic University, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biomedical Sciences, Division of Biochemistry and Molecular Biology, Faculty of Medicine, Padjadjaran University, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department Pathology Anatomy, Faculty of Medicine, Padjadjaran University, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Radiology, Faculty of Medicine, Padjadjaran University, Bandung, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raden Anita Indriyanti</style></author><author><style face="normal" font="default" size="100%">Eko Fuji Ariyanto</style></author><author><style face="normal" font="default" size="100%">Hermin Aminah Usman</style></author><author><style face="normal" font="default" size="100%">Ristaniah Rose Effendy</style></author><author><style face="normal" font="default" size="100%">Diah Dhianawaty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The effect of Sinensetin and Imperatorin on A-549 lung cancer cell viability in vitro</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A549</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell viability</style></keyword><keyword><style  face="normal" font="default" size="100%">Imperatorin</style></keyword><keyword><style  face="normal" font="default" size="100%">Sinensetin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">38-46</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Lung cancer remains the leading cause of cancer death worldwide, so research is ongoing to discover new therapeutics, such as plant-derived bioactive compounds. For example, Sinensetin, a plant-derived polymethoxylated flavonoid, and Imperatorin, a natural furanocoumarin, have anti-cancer properties. This study assessed the effects of sinensetin and imperatorin separately and in combination on A-549 lung cancer cell viability. &lt;strong&gt;Method: &lt;/strong&gt;The A-549 lung cancer cell line was treated with sinensetin (60 μM), imperatorin (30 M), or a combination of both compounds (Sin:Imp 30:30 μM; 50:50 μM and 60:30 μM) for 48 hours. Cell viability was then assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay and apoptosis was determined using fluorescein isothiocyanate (FITC) Annexin-V/Propidium iodide staining. &lt;strong&gt;Results: &lt;/strong&gt;The combination treatment of Sin:Imp 50:50 and Sin:Imp 60:30 μM reduced cell viability more than the individual treatment of sinensetin and imperatorin, with the lowest cell viability observed for the combination treatment of Sin:Imp 50:50 μM. Likewise, the combination treatment of Sin:Imp 50:50 μM induced the most apoptosis compared to individual treatment. &lt;strong&gt;Conclusion:&lt;/strong&gt; Sinensetin and imperatorin can decrease A-549 lung cancer cell viability and are potent apoptotic inducers, especially when they are used in combination, therefore they are potential lung cancer therapeutics.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">38</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Raden Anita Indriyanti&lt;sup&gt;1,2,*&lt;/sup&gt;, Eko Fuji Ariyanto&lt;sup&gt;3&lt;/sup&gt;, Hermin Aminah Usman&lt;sup&gt;4&lt;/sup&gt;, Ristaniah Rose Effendy&lt;sup&gt;5&lt;/sup&gt;, Diah Dhianawaty&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Bandung Islamic University, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Doctoral Program in Medical Science, Faculty of Medicine, Padjadjaran University, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biomedical Sciences, Division of Biochemistry and Molecular Biology, Faculty of Medicine, Padjadjaran University, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department Pathology Anatomy, Faculty of Medicine, Padjadjaran University, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Radiology, Faculty of Medicine, Padjadjaran University, Bandung, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Rauza Sukma Rita</style></author><author><style face="normal" font="default" size="100%">Dachriyanus</style></author><author><style face="normal" font="default" size="100%">Salman Umar</style></author><author><style face="normal" font="default" size="100%">Harrizul Rivai</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study of Sungkai (Peronema canescens, Jack) Leaf Extract Activity as an Immunostimulators With In vivo and In vitro Methods</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cell viability</style></keyword><keyword><style  face="normal" font="default" size="100%">immunostimulant</style></keyword><keyword><style  face="normal" font="default" size="100%">Jack)</style></keyword><keyword><style  face="normal" font="default" size="100%">LPS (lipopolysaccharide)</style></keyword><keyword><style  face="normal" font="default" size="100%">Macrophages</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT (Microtetrazolium)</style></keyword><keyword><style  face="normal" font="default" size="100%">Phagocytosis</style></keyword><keyword><style  face="normal" font="default" size="100%">RAW 264.7 cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Sungkai (Peronema canescens</style></keyword><keyword><style  face="normal" font="default" size="100%">total and percentage of leukocytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1397-1407</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sungkai (&lt;em&gt;Peronema canescens,&lt;/em&gt; Jack.) contains polysaccharides, terpenoids, alkaloids, and polyphenols which have pharmacological activity as immunostimulants. &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to see how the effect of Sungkai extract as an immunostimulant agent was carried out &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in vivo.&lt;/em&gt; &lt;strong&gt;Materials and Methods: &lt;/strong&gt;This study was conducted using two methods, namely&lt;em&gt; in vivo&lt;/em&gt; and &lt;em&gt;in vitro.&lt;/em&gt; &lt;em&gt;In vivo&lt;/em&gt; research method was conducted to test the activity and phagocytic capacity of macrophage cells, the percentage of leukocytes, and the total number of leukocytes. This study used 30 male white mice as the test animals that were randomly divided into 5 treatment groups. Each group was consisting of 6 mice which were given different treatments. The negative control group was given with the 0.5% NaCMC suspension, the mice test substance group was given with the suspension of Sungkai ethanol extract with various doses of 800, 400, and 200 mg/kgBW, and lastly the comparison group was given with the Stimuno in a dose of 50 mg/kg orally for 7 days. On day 8, blood was taken from the mice's vein to count the number and percentage of its leukocytes, then followed by the intraperitoneal injection of a Staphylococcus aureus bacteria suspension. After 1 hour of administration of the bacterial suspension, the peritoneal fluid was taken to be observed for its activity and phagocytic capacity of macrophage cells. The &lt;em&gt;in vitro&lt;/em&gt; research method was used to test the viability and immunostimulatory activity of RAW 264.7 cells with the Sungkai extraction at the concentration of 1.10, 100 g/m. This cell viability test using the microtetrazolium (MTT) method aims to see whether the Sungkai sample used is safe and not toxic to RAW 264.7 cells by observing at the cell viability value that should exceed &amp;gt;90%. The concentration of Sungkai extraction at 1.10, 100 g/mL was found to be safe and non-toxic to RAW 264.7 cells with a viability value of &amp;gt;90%. Thus, this concentration of Sungkai extraction can be performed for its immunostimulatory activity test on LPS induced of RAW 264.7 cells by observing their levels of IL-6 and TNF-α. (proinflammatory cytokines) were compared with the LPS alone as a control using the sandwich ELISA (Enzyme-Linked Immunosorbent Assay) method.&lt;strong&gt; Results: &lt;/strong&gt;The observations were analyzed by one-way ANOVA and Duncan's follow-up test (significance was taken at p&amp;lt;0.05). The results showed that variations in concentration increased significantly (p&amp;lt;0.05) on the activity and phagocytic capacity of macrophage cells, along with the total leukocyte cells. The percentage of leukocytes showed that the cells had a significant increase (p&amp;lt;0.05). It was found that the Sungkai extraction on 1.10, 100 g/mL could significantly increase the concentration of TNF- and IL-6 (p&amp;lt;0.05) which were tested by one-way ANOVA and followed by Duncan's post hoc test. &lt;strong&gt;Conclusion&lt;/strong&gt;: Sungkai leaf extract (Peronemacanescsens Jack.) in a dose of800, 400, and 200 mg/kgBW has an immunostimulant effect both&lt;em&gt; in vivo &lt;/em&gt;and &lt;em&gt;in vitro.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1397</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dwisari Dillasamola&lt;sup&gt;1&lt;/sup&gt;*, Yufri Aldi1, Fatma Sri Wahyuni&lt;sup&gt;1&lt;/sup&gt;, Rauza Sukma Rita&lt;sup&gt;2&lt;/sup&gt;, Dachriyanus&lt;sup&gt;1&lt;/sup&gt;, Salman Umar&lt;sup&gt;1&lt;/sup&gt;, Harrizul Rivai&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universitas Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shabana Bano</style></author><author><style face="normal" font="default" size="100%">Asif Jafri</style></author><author><style face="normal" font="default" size="100%">Nashrah Ahmad</style></author><author><style face="normal" font="default" size="100%">AK Sharma</style></author><author><style face="normal" font="default" size="100%">Md Arshad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Comparative Antibacterial Activity of Three Common Spices Extract and their Anti-Proliferative and Apoptotic Effectiveness against Human Breast Adenocarcinoma Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-proliferative</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptotic</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell viability</style></keyword><keyword><style  face="normal" font="default" size="100%">Nuclear fragmentation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">88-93</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present study was performed to analyse the antibacterial potential as well as the anti-proliferative and apoptotic efficacy of three common spices viz. Cardamom (&lt;em&gt;Elettaria cardamomum&lt;/em&gt;), Cinnamon (&lt;em&gt;Cinnamomum verum&lt;/em&gt;) and Fennel (&lt;em&gt;Foeniculum vulgare&lt;/em&gt;).&lt;strong&gt; Methods:&lt;/strong&gt; Antibacterial activity was determined by well diffusion assay against selected bacterial strains. Anti-proliferative activity was evaluated by cell viability assay and the apoptotic effect was observed by nuclear fragmentation analysis in MCF-7 cells. &lt;strong&gt;Results:&lt;/strong&gt; The antibacterial activity result revealed that Cinnamon extract (CIE) showed maximum antibacterial activity against selected test organism followed by Cardamom (CAE) and Fennel (FEE). The cell viability results revealed that FEE induces the highest cytotoxicity (IC50 73.9 μg/ml) against MCF-7 cells, while CIE showed the lowest efficacy (IC&lt;sub&gt;50&lt;/sub&gt; 98.2 μg/ml) as compared to control. &lt;strong&gt;Conclusion:&lt;/strong&gt; The findings revealed that CIE has the most potent antibacterial efficacy, whereas FEE was found to be a more potent anti-proliferative and apoptotic agent against human breast carcinoma MCF-7 cells.&amp;nbsp;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">88</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Shabana Bano&lt;sup&gt;1*&lt;/sup&gt;, Asif Jafri&lt;sup&gt;2*#&lt;/sup&gt;, Nashrah Ahmad&lt;sup&gt;1&lt;/sup&gt;, AK Sharma&lt;sup&gt;1&lt;/sup&gt;, Md Arshad&lt;sup&gt;2#&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Zoology, University of Lucknow, Lucknow-226007, Uttar Pradesh, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow-226007, Uttar Pradesh, INDIA.&amp;nbsp;&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chethankumara Ganadhal Puttaramaiah</style></author><author><style face="normal" font="default" size="100%">Krishna Venkatarangaiah</style></author><author><style face="normal" font="default" size="100%">Nagaraj Kakanahalli</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Screening In vitro Anticancer Activity of Alseodaphne semecarpifolia Nees Stem Bark Extracts against some Cancer Cell lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alseodaphne semecarpifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Carcinoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell lines</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell viability</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Lymphoma</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">884-888</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cancer is considered as the prime lethal disease that affects different organs of the body. Even with the rapid developments in the medical sciences, there are no proper medicines to cure specific kind of cancer without side effects. The inhibition of tumour cell growth without side effects either by the use herbal or synthetic drugs is considered as an important target in cancer therapy. In traditional medicinal system &lt;em&gt;A. semecarpifolia&lt;/em&gt; stem bark is the prime source of herbal drug to treat lymphatic and skin cancers. &lt;strong&gt;Objective:&lt;/strong&gt; The purpose of this study is to evaluate the anticancer potential of &lt;em&gt;A. semecarpifolia&lt;/em&gt; stem bark extracts against some cancer cell lines. &lt;strong&gt;Methods:&lt;/strong&gt; The&lt;em&gt; in vitro&lt;/em&gt; anticancer activity was evaluated against DLA, EAC, HeLa, HepG2 and L929 cell lines by trypan blue dye exclusion assay and SRB assay. &lt;strong&gt;Results:&lt;/strong&gt; The results of the anticancer activity revealed that, when compared to standard drug Cyclophosphamide, SBPEE and SBCE of A. semecarpifolia showed significant anticancer activity against DLA and EAC cell lines, without causing any toxicity to the normal mouse fibroblast cells L929. Whereas, none of the three extracts showed cytotoxicity against HeLa, HepG2 and L929 cell lines. &lt;strong&gt;Conclusion: &lt;/strong&gt;The present study suggested that, SBPEE and SBCE possesses significant cytotoxic activity against DLA and EAC cell lines, which confirms the traditional medicinal claim of &lt;em&gt;A. semecarpifolia&lt;/em&gt; as a potent anticancer plant against lymphatic and skin cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">884</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Chethankumara Ganadhal Puttaramaiah&lt;sup&gt;1&lt;/sup&gt;, Krishna Venkatarangaiah&lt;sup&gt;2&lt;/sup&gt;, Nagaraj Kakanahalli&lt;sup&gt;3,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Department of PG Studies and Research in Applied Zoology, Kuvempu University, Shivamogga, Karnataka, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Professor, Department of PG Studies and Research in Biotechnology, Kuvempu University, Shivamogga, Karnataka, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Professor, Department of PG Studies and Research in Applied Zoology, Kuvempu University, Shivamogga, Karnataka, INDIA.&lt;/p&gt;
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