<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mila Citrawati</style></author><author><style face="normal" font="default" size="100%">Assyafiya Salwa</style></author><author><style face="normal" font="default" size="100%">Yuni Setyaningsih</style></author><author><style face="normal" font="default" size="100%">Cut Fauziah</style></author><author><style face="normal" font="default" size="100%">Tiwuk Susantiningsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Moringa oleifera Fruit Secondary Metabolites Role in Sarcopenic Obesity via Fat Mass and Obesity-Associated Protein: An In Silico Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">and riboflavin</style></keyword><keyword><style  face="normal" font="default" size="100%">FTO protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera fruit</style></keyword><keyword><style  face="normal" font="default" size="100%">sarcopenic obesity (SO)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">450-457</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Sarcopenic obesity (SO) refers to the coexistence of sarcopenia and obesity, pathogenic interaction between loss of skeletal muscle and function and fat-mass accumulation. Fat mass and obesityassociated (FTO) protein is one of the proteins that involved in pathophysiology of SO. &lt;em&gt;Moringa oleifera&lt;/em&gt; is one of potential drug candidates for degenerative diseases due to its various bioactive metabolites from most parts of this plant. &lt;strong&gt;Objective:&lt;/strong&gt; An&lt;em&gt; in silico&lt;/em&gt; study, employing computational methods to simulate molecular interactions through molecular docking, aims to investigate the potential of &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit secondary metabolites to interact with FTO protein. &lt;strong&gt;Methodology:&lt;/strong&gt; This study was carried out the molecular docking analysis of &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit secondary metabolites that was retrieved from database and have been screened for drug-likeness and toxicity for FTO protein inhibitor candidates. Molecular docking was using Pyrx v0.8, AutoDock 4.2.6 by AutoDockTools 1.5.7, and BIOVIA Discovery studio client 2025 as visualization tools. &lt;strong&gt;Results:&lt;/strong&gt; This study showed 9 bioactive compounds from &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit is bioavailable and safe for oral drugs according to Lipinski Rule of 5 (RO5) and Oral Rat Acute Toxicity (LD50). Molecular docking results showed riboflavin is the most potential compound as FTO protein inhibitor as its strongest affinity and interaction in active site compared to FTO protein native ligands 3-methylthymidine (DT). &lt;strong&gt;Conclusion: &lt;/strong&gt;Therefore, &lt;em&gt;Moringa oleifera &lt;/em&gt;fruit is potential for SO therapy candidates through regulation of FTO protein activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">450</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mila Citrawati&lt;sup&gt;1,2&lt;/sup&gt;, Assyafiya Salwa&lt;sup&gt;1*&lt;/sup&gt;, Yuni Setyaningsih&lt;sup&gt;1,2&lt;/sup&gt;, Cut Fauziah&lt;sup&gt;1&lt;/sup&gt;, Tiwuk Susantiningsih&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Centre for Moringa Oleifera, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amira Kamalrudin</style></author><author><style face="normal" font="default" size="100%">Malina Jasamai</style></author><author><style face="normal" font="default" size="100%">Mahanem Mat Noor</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ameliorative Effect of Moringa oleifera Fruit Extract on Reproductive Parameters in Diabetic-induced Male Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Fasting blood glucose level</style></keyword><keyword><style  face="normal" font="default" size="100%">Male reproductive</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera fruit</style></keyword><keyword><style  face="normal" font="default" size="100%">Sperm quality</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s54-s58</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes mellitus negatively impact the male reproductive parameters. The ability of &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit to improve the reproductive parameters in diabetic-induced male has yet to be documented. Aim: To investigate the anti-hyperglycaemic potential of &lt;em&gt;M. oleifera&lt;/em&gt; fruit aqueous extract and its effect on reproductive parameters in diabetic-induced male rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; A total of 20 male Sprague Dawley rats were divided into four groups; normal control (without diabetic induction), negative control (diabetes without treatment), positive control (diabetes with metformin) and treatment group (diabetes with 500 mg/kg &lt;em&gt;M. oleifera&lt;/em&gt; fruit aqueous extract). Treatments were given&lt;em&gt; via&lt;/em&gt; oral gavage for 21 consecutive days. Analysis of fasting blood glucose level, sperm quality, testicular histology and relative testis weight were performed. &lt;strong&gt;Results:&lt;/strong&gt; The administration of &lt;em&gt;M. oleifera&lt;/em&gt; fruit aqueous extract exhibited a significant reduction in fasting blood glucose level and a pronounced increase in sperm quality (sperm count, motility, viability and morphology) compared with the negative control group. &lt;em&gt;M. oleifera&lt;/em&gt; fruit extract restored the histology of the testes as they were seen to be packed with sperms and showed an organised spermatogenesis. The relative testis weight showed no significant difference between all groups. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results obtained suggested that &lt;em&gt;M. oleifera&lt;/em&gt; fruit aqueous extract possessed an antihyperglycaemic property and improved the reproductive parameters in diabetic-induced rats&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s54</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Amira&lt;/strong&gt;&lt;strong&gt; Kamalrudin&lt;sup&gt;1&lt;/sup&gt;, Malina Jasamai&lt;sup&gt;2&lt;/sup&gt;, Mahanem Mat Noor&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 2&lt;/sup&gt;Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, MALAYSIA.&lt;/p&gt;</style></auth-address></record></records></xml>